1. Subjects with diffuse idiopathic skeletal hyperostosis have an increased burden of coronary artery disease: An evaluation in the COPDGene cohort
- Author
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Oudkerk, Sytse F, Mohamed Hoesein, Firdaus AA, PThM Mali, Willem, Öner, F Cumhur, Verlaan, Jorrit-Jan, de Jong, Pim A, Kinney, Gregory L, Hokanson, John, Lynch, David, Silverman, Edwin K, Budoff, Matthew J, and Regan, Elizabeth A
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Heart Disease - Coronary Heart Disease ,Prevention ,Clinical Research ,Cardiovascular ,Atherosclerosis ,Heart Disease ,Detection ,screening and diagnosis ,4.1 Discovery and preclinical testing of markers and technologies ,Aged ,Aged ,80 and over ,Coronary Artery Disease ,Female ,Follow-Up Studies ,Humans ,Hyperostosis ,Incidence ,Male ,Middle Aged ,Multidetector Computed Tomography ,Retrospective Studies ,Risk Assessment ,Risk Factors ,United States ,Vascular Calcification ,Calciumscore ,CT ,DISH ,Coronary artery disease ,Agatson score ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
Background and aimsDiffuse idiopathic skeletal hyperostosis (DISH) is a common incidental finding on medical imaging and often thought to be benign. Our objective was to investigate whether DISH is associated with coronary artery disease as measured with the coronary artery calcification (CAC) score in a large cohort of current and former smokers.MethodsIn a subset of subjects from the COPDGene study, DISH was scored by a minimum of two independent readers if there were four adjacent levels of flowing osteophytes and a third reader adjudicated discrepancies. CAC was calculated using a modified Agatston method. Associations of DISH with the presence and extent of CAC were analyzed with and without adjustment for COPD and known atherosclerotic risk factors, including age, sex, race, diabetes, hypertension, high cholesterol, body mass index and smoking.ResultsDISH was present in 361 subjects (13.2%) from a total group of 2728. Median (interquartile range) Agatston was 81 (0-329) in DISH subjects compared to 0 (0-94 in subjects without DISH (p
- Published
- 2019