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Your search keyword '"Malhotra, Lakshay"' showing total 14 results
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14 results on '"Malhotra, Lakshay"'

1. Ubiquitin specific peptidase 37 and PCNA interaction promotes osteosarcoma pathogenesis by modulating replication fork progression

Author

Chauhan, Ravi, Gupta, Ashna, Malhotra, Lakshay, Bhat, Ajaz A., Pandita, Raj K., Masoodi, Tariq, Dagar, Gunjan, Sadida, Hana Q., Al-Marzooqi, Sara K., Batra, Atul, Bakhshi, Sameer, Sharma, Mehar Chand, Tanwar, Pranay, Khan, Shah Alam, Samath, Ethayathulla Abdul, Uddin, Shahab, Akil, Ammira S. Al-Shabeeb, Haris, Mohammad, Macha, Muzafar A., Pandita, Tej K., and Singh, Mayank

Published
2023
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8. Abstract 335: Ubiquitin Specific Peptidase 37promotes Osteosarcoma oncogenesis by interacting with PCNA and impacting constitutive replication fork movement.

Author

Chauhan, Ravi, primary, Malhotra, Lakshay, additional, Gupta, Ashna, additional, Bhat, Ajaz, additional, Dagar, Gunjan, additional, Masoodi, Tariq, additional, Macha, Muzafar A., additional, Samath, Ethayathulla Abdul, additional, Batra, Atul, additional, Sharma, Mehar Chand, additional, Haris, Mohammad, additional, Akil, Ammira Al-Shabeeb, additional, Pandita, Tej K., additional, Uddin, Shahab, additional, and Singh, Mayank, additional

Published
2023
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11. Comprehensive omics studies of p53 mutants in human cancer.

Author

Malhotra, Lakshay, Singh, Alankrita, Kaur, Punit, and Ethayathulla, Abdul S

Subjects
*P53 antioncogene, *MISSENSE mutation, *CANCER invasiveness, *MULTIOMICS, *ARRAY processing, *ETIOLOGY of cancer
Abstract

The p53 is the master regulator of the cell known for regulating a large array of cellular processes. Inactivation of p53 by missense mutations is one of the leading causes of cancer. Some of these mutations endow p53 with selective oncogenic functions to promote tumor progression. Due to the vast array of mutations found in p53, the experimental studies showing the role of different mutant p53 as an oncogene are also expanding. In this review, we discuss the oncogenic roles of different p53 mutants at the cellular level identified by multi-omics tools. We discuss some of the therapeutic studies to tackle p53 mutants and their downstream targets identified by omics. We also highlight the future prospective and scope of further studies of downstream p53 targets by omics. [ABSTRACT FROM AUTHOR]

Published
2023
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