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1. Immunologic mediators profile in COVID-19 convalescence

Author

Silva-Junior, Alexander Leonardo, Oliveira, Lucas Silva, Dias, Stephanny, Costa, Thaina Cristina Cardoso, Xabregas, Lilyane Amorim, Alves-Hanna, Fabíola Silva, Abrahim, Cláudia Maria Moura, Neves, Walter Luiz Lima, Crispim, Myuki Alfaia Esashika, Toro, Diana Mota, Silva-Neto, Pedro Vieira, Aponte, Danielle Costa Marques, Oliveira, Tatiana Campos, Silva, Maria Carmo Costa, Matos, Miharu Maguinoria Matsuura, Carvalho, Maria Perpétuo Socorro Sampaio, Tarragô, Andrea Monteiro, Fraiji, Nelson Abrahim, Faccioli, Lúcia Helena, Sorgi, Carlos Artério, Sabino, Ester Cerdeira, Teixeira-Carvalho, Andrea, Martins-Filho, Olindo Assis, Costa, Allyson Guimarães, and Malheiro, Adriana

Published
2024
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3. Exploring cell-derived extracellular vesicles in peripheral blood and bone marrow of B-cell acute lymphoblastic leukemia pediatric patients: proof-of-concept study.

Author

Magalhães-Gama, Fábio, Silvestrini, Marina Malheiros Araújo, Ferreira Neves, Juliana Costa, Araújo, Nilberto Dias, Alves-Hanna, Fabíola Silva, Kerr, Marlon Wendell Athaydes, Carvalho, Maria Perpétuo Socorro Sampaio, Tarragô, Andréa Monteiro, Pontes, Gemilson Soares, Martins-Filho, Olindo Assis, Malheiro, Adriana, Teixeira-Carvalho, Andreá, and Costa, Allyson Guimarães

Subjects
CHILD patients, EXTRACELLULAR vesicles, LYMPHOBLASTIC leukemia, BONE marrow, T cells
Abstract

Extracellular vesicles (EVs) are heterogeneous, phospholipid membrane enclosed particles that are secreted by healthy and cancerous cells. EVs are present in diverse biological fluids and have been associated with the severity of diseases, which indicates their potential as biomarkers for diagnosis, prognosis and as therapeutic targets. This study investigated the phenotypic characteristics of EVs derived from peripheral blood (PB) and bone marrow (BM) in pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL) during different treatment stages. PB and BM plasma were collected from 20 B-ALL patients at three time points during induction therapy, referred to as: diagnosis baseline (D0), day 15 of induction therapy (D15) and the end of the induction therapy (D35). In addition, PB samples were collected from 10 healthy children at a single time point. The EVs were measured using CytoFLEX S flow cytometer. Calibration beads were employed to ensure accurate size analysis. The following, fluorescent-labeled specific cellular markers were used to label the EVs: Annexin V (phosphatidylserine), CD235a (erythrocyte), CD41a (platelet), CD51 (endothelial cell), CD45 (leukocyte), CD66b (neutrophil), CD14 (monocyte), CD3 (T lymphocyte), CD19, CD34 and CD10 (B lymphoblast/leukemic blast). Our results demonstrate that B-ALL patients had a marked production of EV-CD51/61+, EV-CD10+, EV-CD19+ and EV-CD10+CD19+ (double-positive) with a decrease in EV-CD41a+ on D0. However, the kinetics and signature of production during induction therapy revealed a clear decline in EV-CD10+ and EV-CD19+, with an increase of EV-CD41a+ on D35. Furthermore, B-ALL patients showed a complex biological network, exhibiting distinct profiles on D0 and D35. Interestingly, fold change and ROC curve analysis demonstrated that EV-CD10+ CD19+ were associated with B-ALL patients, exhibited excellent clinical performance and standing out as a potential diagnostic biomarker. In conclusion, our data indicate that EVs represent a promising field of investigation in B-ALL, offering the possibility of identifying potential biomarkers and therapeutic targets. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Mediators profile in COVID-19 convalescence: an approach in individuals from amazon

Author

Silva-Junior, Alexander Leonardo, primary, Oliveira, Lucas Silva, additional, Dias, Stephanny, additional, Costa, Thaina Cristina Cardoso, additional, Xabregas, Lilyane Amorim, additional, Alves-Hanna, Fabiola Silva, additional, Abrahim, Cláudia Maria Moura, additional, Neves, Walter Luiz Lima, additional, Crispim, Myuki Alfaia Esashika, additional, Toro, Diana Mota, additional, Silva-Neto, Pedro Vieira, additional, Aponte, Danielle Costa Marques, additional, Oliveira, Tatiana Campos, additional, Silva, Maria Carmo Costa, additional, Matos, Miharu Maguinoria Matsuura, additional, Carvalho, Maria Socorro Sampaio, additional, Tarrago, Andrea Monteiro, additional, Fraiji, Nelson Abrahim, additional, Faccioli, Lúcia Helena, additional, Sorgi, Carlos Artério, additional, Sabino, Ester Cerdeira, additional, Teixeira-Carvalho, Andrea, additional, Martins-Filho, Olindo Assis, additional, Costa, Allyson Guimarães, additional, and Malheiro, Adriana, additional

Published
2024
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5. Virus adsorbent systems based on Amazon holocellulose and nanomaterials

Author

de Souza Carolino, Adriano, primary, Freitas, Xaiane Martins Silva, additional, Macalia, Célio Matias Airone, additional, Soares, Juliana Coatrini, additional, Soares, Andrey Coatrini, additional, da Costa Pinto, Camila, additional, Barbosa, Aguyda Rayany Cavalcante, additional, de Araújo Bezerra, Jaqueline, additional, Campelo, Pedro Henrique, additional, da Silva Paula, Marcos Marques, additional, Lalwani, Pritesh Jaychand, additional, Inada, Natalia Mayumi, additional, Țãlu, Ștefan, additional, Malheiro, Adriana, additional, and Sanches, Edgar Aparecido, additional

Published
2024
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7. Detection of the JAK2V617F in Phildelphia-negative Myeloproliferative Neoplasms patients: Comparison of the PCR-RFLP and Nucleotide sequencing

Author

Laranjeira, Wanessa Horreda, primary, Torres, Dania Isamary Gutierrez, additional, Garcia, Nadja, additional, Costa, Allyson Guimarães da, additional, Malheiro, Adriana, additional, Mourão, Lucivana P. de Souza, additional, Silva, George Allan Villarouco da, additional, and Tarragô, Andréa Monteiro, additional

Published
2023
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8. Genetic polymorphisms of inflammasome genes associated with pediatric acute lymphoblastic leukemia and clinical prognosis in the Brazilian Amazon

Author

Alves, Fabíola Silva, Xabregas, Lilyane Amorim, Kerr, Marlon Wendell Athaydes, Souza, Gláucia Lima, Pereira, Daniele Sá, Magalhães-Gama, Fábio, Santiago, Mirian Rodrigues Ribeiro, Garcia, Nadja Pinto, Tarragô, Andréa Monteiro, Ogusku, Maurício Morishi, Sadahiro, Aya, Malheiro, Adriana, and Costa, Allyson Guimarães

Published
2021
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9. Database resources of the National Center for Biotechnology Information

Author

Sayers, Eric W, primary, Beck, Jeff, additional, Bolton, Evan E, additional, Brister, J Rodney, additional, Chan, Jessica, additional, Comeau, Donald C, additional, Connor, Ryan, additional, DiCuccio, Michael, additional, Farrell, Catherine M, additional, Feldgarden, Michael, additional, Fine, Anna M, additional, Funk, Kathryn, additional, Hatcher, Eneida, additional, Hoeppner, Marilu, additional, Kane, Megan, additional, Kannan, Sivakumar, additional, Katz, Kenneth S, additional, Kelly, Christopher, additional, Klimke, William, additional, Kim, Sunghwan, additional, Kimchi, Avi, additional, Landrum, Melissa, additional, Lathrop, Stacy, additional, Lu, Zhiyong, additional, Malheiro, Adriana, additional, Marchler-Bauer, Aron, additional, Murphy, Terence D, additional, Phan, Lon, additional, Prasad, Arjun B, additional, Pujar, Shashikant, additional, Sawyer, Amanda, additional, Schmieder, Erin, additional, Schneider, Valerie A, additional, Schoch, Conrad L, additional, Sharma, Shobha, additional, Thibaud-Nissen, Françoise, additional, Trawick, Barton W, additional, Venkatapathi, Thilakam, additional, Wang, Jiyao, additional, Pruitt, Kim D, additional, and Sherry, Stephen T, additional

Published
2023
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10. Molecular landscape of the JAK2 gene in chronic myeloproliferative neoplasm patients from the state of Amazonas, Brazil

Author

Torres, Dania, primary, Barbosa Alves, Emanuela, additional, Araújo de Sousa, Miliane, additional, Laranjeira, Wanessa, additional, Paes, Jhemerson, additional, Alves, Erycka, additional, Canté, Deborah, additional, Costa, Allyson, additional, Malheiro, Adriana, additional, Abreu, Rosângela, additional, Nascimento, Leny, additional, Fraiji, Nelson, additional, Silva, George, additional, Mourão, Lucivana, additional, and Tarragô, Andréa, additional

Published
2023
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11. Response to the complete hepatitis B vaccine regimen in infants under 12 months of age: a case series.

Author

Miralha, Alexandre, Malheiro, Adriana, Miranda, Angélica, Rutherford, George, and Alecrim, Maria

Subjects
Brazil, Female, Hepatitis B, Hepatitis B Antibodies, Hepatitis B Surface Antigens, Hepatitis B Vaccines, Hepatitis B virus, Humans, Immunization Schedule, Infant, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Male
Abstract

OBJECTIVES: Describing rates of seroconversion and its associated factors in a series of Brazilian infants following the final dose of the vaccine at 6 months of age. METHODS: Peripheral blood samples were collected after the third dose of the vaccine for the detection of anti-hepatitis B surface antibodies among infants of 7-12 months of age. We measured the association between seroconversion and birthweight, gestational age, time since administration of the vaccine in the maternity hospital and whether or not testing for hepatitis B surface antigen had been performed during pregnancy. RESULTS: We examined 40 infants. The mean birthweight was 2787g (standard deviation=853g) and mean gestational age was 37.5 (standard deviation=3.08) weeks. The proportion that seroconverted was non-significantly higher in infants who weighed ≥2000g at birth (96.7%) than in those with birthweights

Published
2013

12. Plasma Sphingomyelin Disturbances: Unveiling Its Dual Role as a Crucial Imunopathological Factor and a Severity Prognostic Biomarker in COVID-19

Author

Toro, Diana Mota, primary, Da Silva-Neto, Pedro Vieira, additional, De Carvalho, Jonatan Constança Silva, additional, Fuzo, Carlos Alessandro, additional, Pérez, Malena Martínez, additional, Pimentel, Vinícius Eduardo, additional, Fraga-Silva, Thais Fernanda de Campos, additional, Oliveira, Camilla Narjara Simão, additional, Rigotto Caruso, Glaucia, additional, Vilela, Adriana, additional, Nobre, Pedro, additional, Felippe, Thiago, additional, Argolo, Jamille Guedes Malta, additional, Degiovani, Augusto Marcussi, additional, Ostini, Fátima Magro, additional, Feitosa, Marley Ribeiro, additional, Parra, Rogério Serafim, additional, Vilar, Fernando Crivelenti, additional, Gaspar, Gilberto G., additional, Da Rocha, José Joaquim Ribeiro, additional, Feres, Omar, additional, Costa, Gabriel Peinado, additional, Maruyama, Sandra R., additional, De Sousa Russo, Elisa Maria, additional, Fernandes, Ana Paula Morais, additional, Santos, Isabel Kinney Ferreira de Miranda, additional, Malheiro, Adriana, additional, Sadikot, Ruxana T., additional, Bonato, Vânia Luiza Deperon, additional, Cardoso, Cristina Ribeiro de Barros, additional, Dias-Baruffi, Marcelo, additional, Trapé, Átila Alexandre, additional, Faccioli, Lúcia Helena, additional, and Sorgi, Carlos A., additional

Published
2023
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13. Systemic immunological profile of children with B-cell acute lymphoblastic leukemia: performance of cell populations and soluble mediators as serum biomarkers.

Author

Socorro Sampaio Carvalho, Maria Perpétuo, Magalhães-Gama, Fábio, Loiola, Bruna Pires, Ferreira Neves, Juliana Costa, Araújo, Nilberto Dias, Silva, Flavio Souza, Santos Catão, Claudio Lucas, Alves, Eliana Brasil, Diniz Pimentel, João Paulo, Saunier Barbosa, Maria Nazaré, Fraiji, Nelson Abrahim, Teixeira-Carvalho, Andréa, Martins-Filho, Olindo Assis, Costa, Allyson Guimarães, and Malheiro, Adriana

Subjects
CELL populations, LYMPHOBLASTIC leukemia, ACUTE leukemia, REGULATORY T cells, T cells
Abstract

Background: Children with B-cell acute lymphoblastic leukemia (B-ALL) have an immune imbalance that is marked by remodeling of the hematopoietic compartment, with effects on peripheral blood (PB). Although the bone marrow (BM) is the main maintenance site of malignancy, the frequency with which immune cells and molecules can be monitored is limited, thus the identification of biomarkers in PB becomes an alternative for monitoring the evolution of the disease. Methods: Here, we characterize the systemic immunological profile in children undergoing treatment for B-ALL, and evaluate the performance of cell populations, chemokines and cytokines as potential biomarkers during clinical follow-up. For this purpose, PB samples from 20 patients with B-ALL were collected on diagnosis (D0) and during induction therapy (days 8, 15 and 35). In addition, samples from 28 children were used as a control group (CG). The cellular profile (NK and NKT-cells, Treg, CD3+ T, CD4+ T and CD8+ T cells) and soluble immunological mediators (CXCL8, CCL2, CXCL9, CCL5, CXCL10, IL-6, TNF, IFN-γ, IL-17A, IL- 4, IL-10 and IL-2) were evaluated via flow cytometry immunophenotyping and cytometric bead array assay. Results: On D0, B-ALL patients showed reduction in the frequency of cell populations, except for CD4+ T and CD8+ T cells, which together with CCL2, CXCL9, CXCL10, IL-6 and IL-10 were elevated in relation to the patients of the CG. On D8 and D15, the patients presented a transition in the immunological profile. While, on D35, they already presented an opposite profile to D0, with an increase in NKT, CD3+ T, CD4+ T and Treg cells, along with CCL5, and a decrease in the levels of CXCL9, CXCL10 and IL-10, thus demonstrating that B-ALL patients present a complex and dynamic immune network during induction therapy. Furthermore, we identified that many immunological mediators could be used to classify the therapeutic response based on currently used parameters. Conclusion: Finally, it is noted that the systemic immunological profile after remission induction still differs significantly when compared to the GC and that multiple immunological mediators performed well as serum biomarkers. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Exploring the Profile of Cell Populations and Soluble Immunological Mediators in Bothrops atrox Envenomations

Author

Coelho, Kerolaine Fonseca, primary, Neves, Juliana Costa Ferreira, additional, Ibiapina, Hiochelson Najibe Santos, additional, Magalhães-Gama, Fábio, additional, Barbosa, Fabiane Bianca Albuquerque, additional, Silva, Flavio Souza, additional, Wellmann, Irmgardt Alicia María, additional, Sachett, Jacqueline Almeida Gonçalves, additional, Tarragô, Andréa Monteiro, additional, Ferreira, Luiz Carlos Lima, additional, Malheiro, Adriana, additional, Monteiro, Wuelton Marcelo, additional, and Costa, Allyson Guimarães, additional

Published
2023
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18. The Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications

Author

Magalhães-Gama, Fábio, primary, Alves-Hanna, Fabíola Silva, additional, Araújo, Nilberto Dias, additional, Barros, Mateus Souza, additional, Silva, Flavio Souza, additional, Catão, Claudio Lucas Santos, additional, Moraes, Júlia Santos, additional, Freitas, Izabela Cabral, additional, Tarragô, Andréa Monteiro, additional, Malheiro, Adriana, additional, Teixeira-Carvalho, Andréa, additional, and Costa, Allyson Guimarães, additional

Published
2022
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19. Database resources of the National Center for Biotechnology Information in 2023

Author

Sayers, Eric W, primary, Bolton, Evan E, additional, Brister, J Rodney, additional, Canese, Kathi, additional, Chan, Jessica, additional, Comeau, Donald C, additional, Farrell, Catherine M, additional, Feldgarden, Michael, additional, Fine, Anna M, additional, Funk, Kathryn, additional, Hatcher, Eneida, additional, Kannan, Sivakumar, additional, Kelly, Christopher, additional, Kim, Sunghwan, additional, Klimke, William, additional, Landrum, Melissa J, additional, Lathrop, Stacy, additional, Lu, Zhiyong, additional, Madden, Thomas L, additional, Malheiro, Adriana, additional, Marchler-Bauer, Aron, additional, Murphy, Terence D, additional, Phan, Lon, additional, Pujar, Shashikant, additional, Rangwala, Sanjida H, additional, Schneider, Valerie A, additional, Tse, Tony, additional, Wang, Jiyao, additional, Ye, Jian, additional, Trawick, Barton W, additional, Pruitt, Kim D, additional, and Sherry, Stephen T, additional

Published
2022
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20. CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite

Author

Neves, Juliana Costa Ferreira, primary, Ibiapina, Hiochelson Najibe Santos, additional, Magalhães-Gama, Fábio, additional, Sachett, Jacqueline Almeida Gonçalves, additional, Silva, Iran Mendonça, additional, Coelho, Kerolaine Fonseca, additional, Alves, Eliane Campos, additional, Tarragô, Andréa Monteiro, additional, de Lima Ferreira, Luiz Carlos, additional, Malheiro, Adriana, additional, Monteiro, Wuelton Marcelo, additional, and Costa, Allyson Guimarães, additional

Published
2022
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22. Mondo: Unifying diseases for the world, by the world

Author

Vasilevsky, Nicole A, primary, Matentzoglu, Nicolas A, additional, Toro, Sabrina, additional, Flack, Joseph E, additional, Hegde, Harshad, additional, Unni, Deepak R, additional, Alyea, Gioconda F, additional, Amberger, Joanna S, additional, Babb, Larry, additional, Balhoff, James P, additional, Bingaman, Taylor I, additional, Burns, Gully A, additional, Buske, Orion J, additional, Callahan, Tiffany J, additional, Carmody, Leigh C, additional, Cordo, Paula Carrio, additional, Chan, Lauren E, additional, Chang, George S, additional, Christiaens, Sean L, additional, Dumontier, Michel, additional, Failla, Laura E, additional, Flowers, May J, additional, Garrett, H. Alpha, additional, Goldstein, Jennifer L, additional, Gration, Dylan, additional, Groza, Tudor, additional, Hanauer, Marc, additional, Harris, Nomi L, additional, Hilton, Jason A, additional, Himmelstein, Daniel S, additional, Hoyt, Charles Tapley, additional, Kane, Megan S, additional, Köhler, Sebastian, additional, Lagorce, David, additional, Lai, Abbe, additional, Larralde, Martin, additional, Lock, Antonia, additional, López Santiago, Irene, additional, Maglott, Donna R, additional, Malheiro, Adriana J, additional, Meldal, Birgit H M, additional, Munoz-Torres, Monica C, additional, Nelson, Tristan H, additional, Nicholas, Frank W, additional, Ochoa, David, additional, Olson, Daniel P, additional, Oprea, Tudor I, additional, Osumi-Sutherland, David, additional, Parkinson, Helen, additional, Pendlington, Zoë May, additional, Rath, Ana, additional, Rehm, Heidi L, additional, Remennik, Lyubov, additional, Riggs, Erin R, additional, Roncaglia, Paola, additional, Ross, Justyne E, additional, Shadbolt, Marion F, additional, Shefchek, Kent A, additional, Similuk, Morgan N, additional, Sioutos, Nicholas, additional, Smedley, Damian, additional, Sparks, Rachel, additional, Stefancsik, Ray, additional, Stephan, Ralf, additional, Storm, Andrea L, additional, Stupp, Doron, additional, Stupp, Gregory S, additional, Sundaramurthi, Jagadish Chandrabose, additional, Tammen, Imke, additional, Tay, Darin, additional, Thaxton, Courtney L, additional, Valasek, Eloise, additional, Valls-Margarit, Jordi, additional, Wagner, Alex H, additional, Welter, Danielle, additional, Whetzel, Patricia L, additional, Whiteman, Lori L, additional, Wood, Valerie, additional, Xu, Colleen H, additional, Zankl, Andreas, additional, Zhang, Xingmin Aaron, additional, Chute, Christopher G, additional, Robinson, Peter N, additional, Mungall, Christopher J, additional, Hamosh, Ada, additional, and Haendel, Melissa A, additional

Published
2022
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23. Lower levels of CXCL-8 and IL-2 on admission as predictors of early adverse reactions to Bothrops antivenom in the Brazilian Amazon

Author

Soares, Frandison G S, primary, Ibiapina, Hiochelson N., additional, Sartim, Marco A., additional, Mendonça-da-Silva, Iran, additional, Nascimento, Elizandra F., additional, Ferreira, Luiz C.L., additional, Cerni, Felipe A., additional, Malheiro, Adriana, additional, Pucca, Manuela B., additional, Wen, Fan H., additional, Maria Moura-da-Silva, Ana, additional, Costa, Allyson G., additional, Monteiro, Wuelton M., additional, and Sachett, Jacqueline A.G., additional

Published
2022
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24. Clinical Implication of SNVs in TLR Genes in Pediatric Patients From the Brazilian Amazon With Acute Lymphoblastic Leukemia

Author

Xabregas, Lilyane Amorim, primary, Hanna, Fabíola Silva Alves, additional, Magalhães-Gama, Fábio, additional, Souza, Gláucia Lima, additional, Pereira, Daniele Sá, additional, Lima, Amanda Barros, additional, Toro, Diana Mota, additional, Santiago, Mirian Rodrigues Ribeiro, additional, Passos, Leny Nascimento Motta, additional, Tarragô, Andréa Monteiro, additional, Malheiro, Adriana, additional, and Costa, Allyson Guimarães, additional

Published
2022
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27. Bone Marrow Soluble Immunological Mediators as Clinical Prognosis Biomarkers in B-Cell Acute Lymphoblastic Leukemia Patients Undergoing Induction Therapy

Author

Kerr, Marlon Wendell Athaydes, primary, Magalhães-Gama, Fábio, additional, Ibiapina, Hiochelson Najibe Santos, additional, Hanna, Fabíola Silva Alves, additional, Xabregas, Lilyane Amorim, additional, Alves, Eliana Brasil, additional, Pimentel, João Paulo Diniz, additional, Carvalho, Maria Perpétuo Socorro Sampaio, additional, Tarragô, Andréa Monteiro, additional, Teixeira-Carvalho, Andréa, additional, Martins-Filho, Olindo Assis, additional, da Costa, Allyson Guimarães, additional, and Malheiro, Adriana, additional

Published
2021
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28. γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends

Author

Barros, Mateus de Souza, primary, de Araújo, Nilberto Dias, additional, Magalhães-Gama, Fábio, additional, Pereira Ribeiro, Thaís Lohana, additional, Alves Hanna, Fabíola Silva, additional, Tarragô, Andréa Monteiro, additional, Malheiro, Adriana, additional, and Costa, Allyson Guimarães, additional

Published
2021
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29. Neutrophil extracellular trap regulators in sickle cell disease: Modulation of gene expression of PADI4, neutrophil elastase, and myeloperoxidase during vaso‐occlusive crisis

Author

Hounkpe, Bidossessi Wilfried, Chenou, Francine, Domingos, Igor de Farias, Cardoso, Evilazio Cunha, Costa Sobreira, Marcondes José de Vasconcelos, Araujo, Aderson S., Lucena‐Araújo, Antonio Roberto, da Silva Neto, Pedro Vieira, Malheiro, Adriana, Fraiji, Nelson Abrahim, Costa, Fernando Ferreira, Bezerra, Marcos André C., Santos, Magnun Nueldo Nunes, and De Paula, Erich Vinicius

Published
2021
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30. Imbalance of Chemokines and Cytokines in the Bone Marrow Microenvironment of Children with B-Cell Acute Lymphoblastic Leukemia

Author

Magalhães-Gama, Fábio, primary, Kerr, Marlon Wendell Athaydes, additional, de Araújo, Nilberto Dias, additional, Ibiapina, Hiochelson Najibe Santos, additional, Neves, Juliana Costa Ferreira, additional, Hanna, Fabíola Silva Alves, additional, Xabregas, Lilyane de Amorim, additional, Carvalho, Maria Perpétuo Socorro Sampaio, additional, Alves, Eliana Brasil, additional, Tarragô, Andréa Monteiro, additional, Martins-Filho, Olindo Assis, additional, Teixeira-Carvalho, Andréa, additional, Malheiro, Adriana, additional, and da Costa, Allyson Guimarães, additional

Published
2021
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32. Inflammasome genes polymorphisms may influence the development of hepatitis C in the Amazonas, Brazil

Author

Toro, Diana Mota, primary, Ramasawmy, Rajendranath, additional, Silva Neto, Pedro Vieira, additional, Pereira, Grenda Leite, additional, Sarmento, Priscila Santos, additional, Dray, Hanna Lara Silva Negreiros, additional, Sousa, Keyla Santos, additional, Affonso, Juliana Santos, additional, Silva, Jéssica Albuquerque, additional, Garcia, Nadja Pinto, additional, Barbieri, Marilú Victória, additional, Victória, Flamir Silva, additional, Donadi, Eduardo Antônio, additional, Costa, Allyson Guimarães, additional, Ogusku, Mauricio Morishi, additional, Sadahiro, Aya, additional, Tarragô, Andréa Monteiro, additional, and Malheiro, Adriana, additional

Published
2021
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34. Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity

Author

de Araújo, Nilberto Dias, Gama, Fábio Magalhães, de Souza Barros, Mateus, Ribeiro, Thaís Lohana Pereira, Alves, Fabíola Silva, Xabregas, Lilyane Amorim, Tarragô, Andréa Monteiro, Malheiro, Adriana, and Costa, Allyson Guimarães

Subjects
Article Subject
Abstract

Recently, cell-mediated immune response in malignant neoplasms has become the focus in immunotherapy against cancer. However, in leukemia, most studies on the cytotoxic potential of T cells have concentrated only on T cells that recognize peptide antigens (Ag) presented by polymorphic molecules of the major histocompatibility complex (MHC). This ignores the great potential of unconventional T cell populations, which include gamma-delta T cells (γδ), natural killer T cells (NKT), and mucosal-associated invariant T cells (MAIT). Collectively, these T cell populations can recognize lipid antigens, specially modified peptides and small molecule metabolites, in addition to having several other advantages, which can provide more effective applications in cancer immunotherapy. In recent years, these cell populations have been associated with a repertoire of anti- or protumor responses and play important roles in the dynamics of solid tumors and hematological malignancies, thus, encouraging the development of new investigations in the area. This review focuses on the current knowledge regarding the role of unconventional T cell populations in the antitumor immune response in leukemia and discusses why further studies on the immunotherapeutic potential of these cells are needed.

Published
2021
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40. Immunological Hallmarks of Inflammatory Status in Vaso-Occlusive Crisis of Sickle Cell Anemia Patients

Author

Silva-Junior, Alexander Leonardo, primary, Garcia, Nadja Pinto, additional, Cardoso, Evilázio Cunha, additional, Dias, Stephanny, additional, Tarragô, Andrea Monteiro, additional, Fraiji, Nelson Abrahim, additional, Gomes, Matheus Souza, additional, Amaral, Laurence Rodrigues, additional, Teixeira-Carvalho, Andréa, additional, Martins-Filho, Olindo Assis, additional, De Paula, Erich Vinicius, additional, Costa, Allyson Guimarães, additional, and Malheiro, Adriana, additional

Published
2021
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41. Crosstalk between perivascular adipose tissue and blood vessels in obesity and type 2 diabetes

Author

Malheiro, Adriana António Lemos Gonçalves and Sena, Cristina Maria Tristão

Subjects
nitric oxide, perivascular adipose tissue, endothelin-1, diabetes tipo 2, óxido nítrico, type 2 diabetes, tecido adiposo perivascular, endotelina-1, disfunção endotelial, endothelial dysfunction
Abstract

Dissertação de Mestrado em Química Medicinal apresentada à Faculdade de Ciências e Tecnologia Diabetes mellitus (DM) is a metabolic pathology with increasing prevalence in the western society. DM is characterized by hyperglycemia resulting from defects in insulin secretion or action, or both. Therefore, chronic hyperglycemia is, in long-term, associated with damage, dysfunction and failure of various organs. Diabetes is closely linked to endothelial dysfunction, atherosclerosis, dyslipidemia and obesity. Insulin resistance, which accompanies obesity and type 2 diabetes, is a condition in which cells are resistant to insulin action and are unable to absorb glucose from the bloodstream and, thus, lead to hyperglycemia.Over the last years, perivascular adipose tissue (PVAT) has emerged as an active component of the blood vessel wall, with endocrine and paracrine functions, that regulates vascular homeostasis and that plays a role on the pathogenesis of cardiovascular diseases. In physiological conditions, this tissue synthetizes a variety of adipokines that contribute to regulation of vascular tone and local inflammation, due to the balance between nitric oxide and endothelin-1. On the other hand, in vascular pathologies, PVAT increases in volume, becomes dysfunctional and leads to a series of physiological complications.This work utilizes two different models with expectations to bring new insights on the field. These two models were used to study the impact of western hypercaloric diets (high-fat diet and fat diet with methylglyoxal) on PVAT and endothelial function. The first animal model evaluates the impact of type 2 diabetes on PVAT and its vascular implications. The second model allows an assessment of a diet rich in fat and methylglyoxal in PVAT to study its vascular outcome. In fact, our results suggest that the fat diet alone induces not only insulin resistance, but also a considerable degree of PVAT dysfunction. Surprisingly, we showed some similarity between the models in terms of the loss of the anticontractile effect of perivascular adipose tissue. A diabetes mellitus (DM) é uma patologia metabólica com uma prevalência crescente na sociedade ocidental. A DM é caracterizada por hiperglicémia resultante de defeitos na secreção ou ação de insulina, ou ambos. Por conseguinte, a hiperglicémia crónica está associada, a longo prazo, a danos, disfunção e falha de vários órgãos. A diabetes encontra-se intimamente associada a disfunção endotelial, aterosclerose, dislipidemia e obesidade. A resistência à insulina, que acompanha a obesidade e a diabetes tipo 2, é uma condição na qual as células apresentam resistência à ação da insulina e não são capazes de absorver glicose da corrente sanguínea que, desta forma, conduz a hiperglicémia.Nos últimos anos, o tecido adiposo perivascular (do inglês, PVAT) tem captado a atenção da comunidade científica devido às suas funções endócrinas e parácrinas como constituinte da parede dos vasos sanguíneos. Desempenha, ainda, um papel fundamental no desenvolvimento de doenças cardiovasculares. Em condições fisiológicas, este tecido sintetiza uma série de moléculas que contribuem para a regulação do tónus vascular e da inflamação local, devido ao equilíbrio entre substâncias vasodilatadoras, como o óxido nítrico, e vasoconstritoras, como a endotelina-1. Por outro lado, em situações patológicas, o PVAT aumenta de volume, torna-se disfuncional e leva a várias complicações micro e macrovasculares.Este trabalho utiliza dois modelos animais diferentes, com o propósito de estudar o impacto de dietas ocidentais hipercalóricas (dieta rica em gordura e dieta gorda com metilglioxal) no PVAT e avaliar a disfunção endotelial associada. O primeiro modelo animal estuda o impacto da diabetes tipo 2 no PVAT e suas implicações vasculares. O segundo modelo permite fazer uma avaliação de uma dieta rica em gordura com metilglioxal no PVAT e estudar o seu impacto vascular. De facto, os nossos resultados sugerem que a dieta gorda, por si só, induz não só insulinorresistência, como também um grau de disfunção do PVAT bastante considerável. Surpreendentemente, mostrámos alguma similaridade entre os modelos em termos da perda do efeito anticontrátil do tecido adiposo perivascular.

Published
2020

42. Severe tissue complications in patients of Bothrops snakebite at a tertiary health unit in the Brazilian Amazon: clinical characteristics and associated factors

Author

Silva, Flavio Souza, primary, Ibiapina, Hiochelson Najibe Santos, additional, Neves, Juliana Costa Ferreira, additional, Coelho, Kerolaine Fonseca, additional, Barbosa, Fabiane Bianca Albuquerque, additional, Lacerda, Marcus Vinicius Guimarães, additional, Sachett, Jacqueline Almeida Gonçalves, additional, Malheiro, Adriana, additional, Monteiro, Wuelton Marcelo, additional, and Costa, Allyson Guimarães, additional

Published
2021
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45. Development of an immunoassay for the detection of human IgG against hepatitis C virus proteins using magnetic beads and flow cytometry

Author

Neves, Walter Luiz Lima, primary, Mariuba, Luis André Morais, additional, Alves, Késsia Caroline Souza, additional, Coelho, Kerolaine Fonseca, additional, Tarragô, Andrea Monteiro, additional, Costa, Allyson Guimarães, additional, Chaves, Yury Oliveira, additional, Victoria, Flamir da Silva, additional, Victoria, Marilu Barbieri, additional, and Malheiro, Adriana, additional

Published
2020
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46. The NIH genetic testing registry: a new, centralized database of genetic tests to enable access to comprehensive information and improve transparency

Author

Rubinstein, Wendy S., Maglott, Donna R., Lee, Jennifer M., Kattman, Brandi L., Malheiro, Adriana J., Ovetsky, Michael, Hem, Vichet, Gorelenkov, Viatcheslav, Song, Guangfeng, Wallin, Craig, Husain, Nora, Chitipiralla, Shanmuga, Katz, Kenneth S., Hoffman, Douglas, Jang, Wonhee, Johnson, Mark, Karmanov, Fedor, Ukrainchik, Alexander, Denisenko, Mikhail, Fomous, Cathy, Hudson, Kathy, and Ostell, James M.

Published
2013
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47. Prognostic value of sTREM-1 in COVID-19 patients: a biomarker for disease severity and mortality

Author

da Silva Neto, Pedro V., primary, de Carvalho, Jonatan C. S., additional, Pimentel, Vinícius E., additional, Pérez, Malena M., additional, Carmona-Garcia, Ingryd, additional, Neto, Nicola T., additional, Toro, Diana M., additional, Oliveira, Camilla N. S., additional, Fraga-Silva, Thais F. C., additional, Milanezi, Cristiane M., additional, Rodrigues, Lilian C., additional, Dias, Cassia F. S. L., additional, Xavier, Ana C., additional, Porcel, Giovanna S., additional, Guarneri, Isabelle C., additional, Zaparoli, Kamila, additional, Garbato, Caroline T., additional, Argolo, Jamille G. M., additional, Júnior, Ângelo A. F., additional, de Amorim, Alessandro P., additional, Degiovani, Augusto M., additional, da Silva, Dayane P., additional, Nepomuceno, Debora C., additional, da Silva, Rafael C., additional, Constant, Leticia F., additional, Ostini, Fátima M., additional, Feitosa, Marley R., additional, Parra, Rogerio S., additional, Vilar, Fernando C., additional, Gaspar, Gilberto G., additional, da Rocha, José J. R., additional, Feres, Omar, additional, Barbieri, Rita C. C., additional, Frantz, Fabiani G., additional, Maruyama, Sandra R., additional, Russo, Elisa M. S., additional, Viana, Angelina L., additional, Fernandes, Ana P. M., additional, Santos, Isabel K. F. M., additional, Bonato, Vânia L. D., additional, Dias-Baruffi, Marcelo, additional, Malheiro, Adriana, additional, Sadikot, Ruxana T., additional, Cardoso, Cristina R. B., additional, Faccioli, Lúcia H., additional, and Sorgi, Carlos A., additional

Published
2020
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48. Correlating Fibrinogen Consumption and Profiles of Inflammatory Molecules in Human Envenomation's by Bothrops atrox in the Brazilian Amazon

Author

Wellmann, Irmgardt Alicia María, primary, Ibiapina, Hiochelson Najibe Santos, additional, Sachett, Jacqueline Almeida Gonçalves, additional, Sartim, Marco Aurélio, additional, Silva, Iran Mendonça, additional, Oliveira, Sâmella Silva, additional, Tarragô, Andréa Monteiro, additional, Moura-da-Silva, Ana Maria, additional, Lacerda, Marcus Vinícius Guimarães, additional, Ferreira, Luiz Carlos de Lima, additional, Malheiro, Adriana, additional, Monteiro, Wuelton Marcelo, additional, and Costa, Allyson Guimarães, additional

Published
2020
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49. Combination of genetic polymorphisms in TLR influence cytokine profile in HCV patients treated with DAAs in the State of Amazonas

Author

Tarragô, Andréa Monteiro, primary, da Silva Neto, Pedro Vieira, additional, Ramasawmy, Rajendranath, additional, Pereira, Grenda Leite, additional, Toro, Diana Mota, additional, de Amorim Xabregas, Lilyane, additional, Costa, Allyson Guimaraes, additional, Victória, Marilú Barbieri, additional, da Silva Victória, Flamir, additional, and Malheiro, Adriana, additional

Published
2020
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50. How the NIH Genetic Testing Registry and Medical Genetics Summaries can help oncologists adopt pharmacogenetics guidelines.

Author

Malheiro, Adriana Jose, primary, Dean, Laura Charlotte, additional, Hoeppner, Marilu A, additional, Lyoshin, Vitaliy, additional, Gu, Baoshan, additional, Chen, Chao, additional, Liu, Chunlei, additional, Maddipatla, Zenith, additional, Shi, Wenyao, additional, Jang, Wonhee, additional, Hoffman, Douglas, additional, Zhou, George, additional, Chitipiralla, Shanmuga, additional, Mitchell, Joe, additional, Maglott, Donna R., additional, and Kattman, Brandi L., additional

Published
2020
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