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6 results on '"Malgaz M"'

1. [Auditory verbal hallucinations in an adult with autism spectrum disorder]

Author

Malgaz M, Cf, Kesteren, and iris sommer

Subjects
Adult, Male, Treatment Outcome, Hallucinations, Child Development Disorders, Pervasive, Intellectual Disability, Humans, Comorbidity
Abstract

Auditory verbal hallucinations (avh) are known to occur in relative isolation in various psychiatric disorders and as well in autism spectrum disorder (ASD). Up till now, research into the occurrence of auditory verbal hallucinations in patients who have a psychiatric disorder and ASD has been very limited. In order to give some indication about the effects of such a combination in one individual, we present a case-description of a 37-year-old man diagnosed with both pervasive developmental disorder--not otherwise specified (pdd-nos) and a mild intellectual disability. He was treated at the specialised outpatient 'Voices Clinic' of the University Hospital in Utrecht UMC. The patient responsed well treatment.

Published
2015

2. Stemmen horen bij een volwassene met een autismespectrumstoornis

Author

Malgaz, M, van Kesteren, C F M G, and Sommer, I E

Subjects
Adult, Male, Treatment Outcome, Hallucinations, Child Development Disorders, Pervasive, Intellectual Disability, mental disorders, Humans, Comorbidity, Case Reports, behavioral disciplines and activities, auditieve verbale hallucinaties, autismespectrumstoornis
Abstract

Auditory verbal hallucinations (avh) are known to occur in relative isolation in various psychiatric disorders and as well in autism spectrum disorder (ASD). Up till now, research into the occurrence of auditory verbal hallucinations in patients who have a psychiatric disorder and ASD has been very limited. In order to give some indication about the effects of such a combination in one individual, we present a case-description of a 37-year-old man diagnosed with both pervasive developmental disorder--not otherwise specified (pdd-nos) and a mild intellectual disability. He was treated at the specialised outpatient 'Voices Clinic' of the University Hospital in Utrecht UMC. The patient responsed well treatment.

Published
2015

3. Stemmen horen bij een volwassene met een autismespectrumstoornis

Author

AIOS Psychiatrie, CTI Nierkens, Affectieve & Psychotisch Ond., Brain, Malgaz, M, van Kesteren, C F M G, Sommer, I E, AIOS Psychiatrie, CTI Nierkens, Affectieve & Psychotisch Ond., Brain, Malgaz, M, van Kesteren, C F M G, and Sommer, I E

Published
2015

4. Mid-dosing interval efavirenz plasma concentrations in HIV-1-infected children in Rwanda: treatment efficacy, tolerability, adherence, and the influence of CYP2B6 polymorphisms.

Author

Mutwa, P.R., Fillekes, Q., Malgaz, M., Tuyishimire, D., Kraats, R. van, Boer, K.R., Burger, D.M., Schaik, R.H. van, Muganga, N., Geelen, S.P.M., Mutwa, P.R., Fillekes, Q., Malgaz, M., Tuyishimire, D., Kraats, R. van, Boer, K.R., Burger, D.M., Schaik, R.H. van, Muganga, N., and Geelen, S.P.M.

Abstract

Item does not contain fulltext, This study evaluated mid-dosing interval efavirenz plasma concentrations and the influence of CYP2B6 polymorphisms in relation to efficacy, tolerability, and adherence in 97 Rwandan HIV-infected children (3-16 years). Plasma drug concentrations and CYP2B6 polymorphisms were determined. Ten children were excluded for nonadherence. Large intersubject variability in efavirenz plasma concentrations was found. Of the 87 remaining, efavirenz concentrations were therapeutic, supratherapeutic, and subtherapeutic in 67%, 20%, and 14%, respectively. No associations were found between efavirenz concentrations and central nervous system disturbances or virologic failure. Minor allele frequencies were 0.32 (516G>T), 0.33 (785A>G), and 0.09 (983T>C). Polymorphisms in CYP2B6 were strongly associated with high efavirenz levels.

Published
2012

5. Multivariate genome-wide analysis of stress-related quantitative phenotypes.

Author

Schijven D, Geuze E, Vinkers CH, Pulit SL, Schür RR, Malgaz M, Bekema E, Medic J, van der Kust KE, Veldink JH, Boks MP, Vermetten E, and Luykx JJ

Subjects
Adolescent, Adult, Afghan Campaign 2001-, Cohort Studies, Humans, Longitudinal Studies, Male, Middle Aged, Multivariate Analysis, Polymorphism, Single Nucleotide genetics, Stress Disorders, Post-Traumatic blood, Young Adult, Genome-Wide Association Study methods, Military Personnel psychology, Phenotype, Quantitative Trait Loci genetics, Stress Disorders, Post-Traumatic genetics, Stress Disorders, Post-Traumatic psychology
Abstract

Exposure to traumatic stress increases the odds of developing a broad range of psychiatric conditions. Genetic studies targeting multiple stress-related quantitative phenotypes may shed light on mechanisms underlying vulnerability to psychopathology in the aftermath of stressful events. We applied a multivariate genome-wide association study (GWAS) to a unique military cohort (N = 583) in which we measured biochemical and behavioral phenotypes. The availability of pre- and post-deployment measurements allowed to capture changes in these phenotypes in response to stress. For genome-wide significant loci, we performed functional annotation, phenome-wide analysis and quasi-replication in PTSD case-control GWASs. We discovered one genetic variant reaching genome-wide significant association, surviving permutation and sensitivity analyses (rs10100651, p = 9.9 × 10 -9 ). Functional annotation prioritized the genes INTS8 and TP53INP1. A phenome-wide scan revealed a significant association of these same genes with sleeping problems, hypertension and subjective well-being. Finally, a targeted lookup revealed nominally significant association of rs10100651 in a PTSD case-control GWAS in the UK Biobank (p = 0.02). We provide comprehensive evidence from multiple resources hinting at a role of the highlighted genetic variant in the human stress response, marking the power of multivariate genome-wide analysis of quantitative measures in stress research. Future genetic and functional studies can target this locus to further assess its effects on stress mediation and its possible role in psychopathology or resilience., (Copyright © 2019. Published by Elsevier B.V.)

Published
2019
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6. Mid-dosing interval efavirenz plasma concentrations in HIV-1-infected children in Rwanda: treatment efficacy, tolerability, adherence, and the influence of CYP2B6 polymorphisms.

Author

Mutwa PR, Fillekes Q, Malgaz M, Tuyishimire D, Kraats Rv, Boer KR, Burger DM, van Schaik RH, Muganga N, and Geelen SP

Subjects
Adolescent, Alkynes, Anti-HIV Agents administration & dosage, Anti-HIV Agents adverse effects, Benzoxazines administration & dosage, Benzoxazines adverse effects, Child, Child, Preschool, Cyclopropanes, Cytochrome P-450 CYP2B6, Female, Gene Frequency, HIV Infections virology, HIV-1 isolation & purification, Humans, Male, Rwanda, Treatment Outcome, Viral Load, Anti-HIV Agents pharmacokinetics, Aryl Hydrocarbon Hydroxylases genetics, Benzoxazines pharmacokinetics, HIV Infections drug therapy, Oxidoreductases, N-Demethylating genetics, Plasma chemistry, Polymorphism, Genetic
Abstract

This study evaluated mid-dosing interval efavirenz plasma concentrations and the influence of CYP2B6 polymorphisms in relation to efficacy, tolerability, and adherence in 97 Rwandan HIV-infected children (3-16 years). Plasma drug concentrations and CYP2B6 polymorphisms were determined. Ten children were excluded for nonadherence. Large intersubject variability in efavirenz plasma concentrations was found. Of the 87 remaining, efavirenz concentrations were therapeutic, supratherapeutic, and subtherapeutic in 67%, 20%, and 14%, respectively. No associations were found between efavirenz concentrations and central nervous system disturbances or virologic failure. Minor allele frequencies were 0.32 (516G>T), 0.33 (785A>G), and 0.09 (983T>C). Polymorphisms in CYP2B6 were strongly associated with high efavirenz levels.

Published
2012
Full Text
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