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6. Percutaneous Joint Injections

Author

Finzel, Kathleen C., Adler, Ronald S., Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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7. Percutaneous Treatment of Intervertebral Disc Herniation

Author

Buy, Xavier, Gangi, Afshin, Guth, Stéphane, Guermazi, Ali, Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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8. Percutaneous Treatment of Chronic Low Back Pain

Author

Buy, Xavier, Gangi, Afshin, Guermazi, Ali, Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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9. Percutaneous Bone Biopsy

Author

Bierry, Guillaume, Buy, Xavier, Guth, Stéphane, Guermazi, Ali, Gangi, Afshin, Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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10. Procedure Basics and Technique Guidance

Author

Guth, Stéphane, Buy, Xavier, Guermazi, Ali, Gangi, Afshin, Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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11. Provocative Discography

Author

Peh, Wilfred C. G., Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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12. Percutaneous Infiltration of the Craniovertebral Region

Author

Chevrot, Alain, Drapé, Jean-Luc, Godefroy, Didier, Feydy, Antoine, Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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13. Percutaneous Biopsy of Soft Tissues and Muscular Lesions

Author

Hodge, Jacqueline C., Mattila, Kimmo, Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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14. Percutaneous Spinal Facet and Sacroiliac Joint Injection

Author

Levin, Galina, Luchs, Jonathan S., Ortiz, A. Orlando, Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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15. Interventional Vascular Radiology in Musculoskeletal Lesions

Author

Klurfan, Paula, TerBrugge, Karel G., Tan, Kongteng, Simons, Martin E., Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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16. Ultrasound-Guided Musculoskeletal Interventional Procedures

Author

Peetrons, Philippe, Court-Payen, Michel, Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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17. Closed Reduction and Percutaneous Fixation of Pelvic Fractures

Author

Huegli, Rolf, Gross, Thomas, Jacob, Augustinus L., Messmer, Peter, Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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18. Percutaneous Bone Tumors Management

Author

Gangi, Afshin, Buy, Xavier, Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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19. Percutaneous Management of Painful Shoulder

Author

Parlier-Cuau, Caroline, Wybier, Marc, Hamze, Bassam, Laredo, Jean-Denis, Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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20. Percutaneous Kyphoplasty in Vertebral Compression Fractures

Author

Hacein-Bey, Lotfi, Guermazi, Ali, Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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21. Percutaneous Intraosseous Cyst Management

Author

Dubois, Josée, Garel, Laurent, Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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22. Percutaneous Cementoplasty

Author

Gangi, Afshin, Buy, Xavier, Irani, Farah, Guth, Stéphane, Guermazi, Ali, Imbert, Jean-Pierre, Dietemann, Jean-Louis, Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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23. Percutaneous Interventions in the Management of Soft Tissue Conditions

Author

Malfair, David, Munk, Peter L., Baert, A. L., editor, Knauth, M., editor, Sartor, K., editor, Gangi, Afshin, editor, Guth, Stéphane, editor, Guermazi, Ali, editor, Adler, R. S., Book editor, Bierry, G., Book editor, Buy, X., Book editor, Chevrot, A., Book editor, Court-Payen, M., Book editor, Dietemann, J. -L., Book editor, Drapé, J. -L., Book editor, Dubois, J., Book editor, Feydy, A., Book editor, Finzel, K. C., Book editor, Gangi, A., Book editor, Garel, L., Book editor, Godefroy, D., Book editor, Gross, T., Book editor, Guermazi, A., Book editor, Guth, S., Book editor, Hacein-Bey, L., Book editor, Hamze, B., Book editor, Hodge, J. C., Book editor, Huegli, R., Book editor, Imbert, J. -P., Book editor, Irani, F., Book editor, Jacob, A. L., Book editor, Klurfan, P., Book editor, Laredo, J. -D., Book editor, Levin, G., Book editor, Luchs, J. S., Book editor, Malfair, D., Book editor, Mattila, K., Book editor, Messmer, P., Book editor, Munk, P. L., Book editor, Ortiz, A. O., Book editor, Parlier-Cuau, C., Book editor, Peetrons, P., Book editor, Peh, W. C. G., Book editor, Simons, M. E., Book editor, Tan, K., Book editor, TerBrugge, K. G., Book editor, and Wybier, M., Book editor

Published
2009
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25. Extrahepatic metastases of hepatocellular carcinoma: A spectrum of imaging findings.

Author

Becker AK, Tso DK, Harris AC, Malfair D, and Chang SD

Subjects
Bone Neoplasms diagnosis, Bone Neoplasms secondary, Brain Neoplasms diagnosis, Brain Neoplasms secondary, Carcinoma, Hepatocellular pathology, Disease Progression, Female, Humans, Lung Neoplasms diagnosis, Lung Neoplasms secondary, Lymphatic Metastasis, Male, Neoplasm Invasiveness, Retroperitoneal Neoplasms diagnosis, Retroperitoneal Neoplasms secondary, Urogenital Neoplasms diagnosis, Urogenital Neoplasms secondary, Vascular Neoplasms diagnosis, Vascular Neoplasms secondary, Carcinoma, Hepatocellular diagnosis, Carcinoma, Hepatocellular secondary, Liver Neoplasms diagnosis, Liver Neoplasms pathology, Magnetic Resonance Imaging methods, Tomography, X-Ray Computed methods
Abstract

Hepatocellular carcinoma (HCC) is the most common primary tumour of the liver, responsible for significant morbidity and mortality worldwide. In the Western world, it primarily affects patients with cirrhosis, secondary to hepatitis C virus and alcoholism. In the rest of the world, HCC is closely associated with hepatitis B virus infections. Radiologists play a key role in accurately staging HCC, which has important implications for treatment planning. This pictorial review aims to describe the routes of HCC spread and the most frequent sites of metastases, to recognize extrahepatic HCC findings on computed tomography and magnetic resonance imaging, and to understand the implications of HCC staging on treatment planning., (Copyright © 2014 Canadian Association of Radiologists. Published by Elsevier Inc. All rights reserved.)

Published
2014
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26. Comparison of MERGE and axial T2-weighted fast spin-echo sequences for detection of multiple sclerosis lesions in the cervical spinal cord.

Author

Martin N, Malfair D, Zhao Y, Li D, Traboulsee A, Lang D, and Vertinsky AT

Subjects
Adult, Artifacts, Case-Control Studies, Cervical Vertebrae, Female, Humans, Male, Retrospective Studies, Sensitivity and Specificity, Image Enhancement methods, Magnetic Resonance Imaging methods, Multiple Sclerosis diagnosis, Spinal Cord pathology
Abstract

Objective: The purpose of our study was to compare axial multiple-echo recombined gradient echo (MERGE) with axial T2-weighted fast spin-echo (FSE) imaging for the detection of multiple sclerosis (MS) lesions in the cervical spinal cord on MRI., Materials and Methods: Twenty-nine cervical spine MRI studies of patients with MS lesions and 29 control cases were reviewed retrospectively. Two blinded neuroradiologists independently assessed randomized axial MERGE and axial T2-weighted FSE sequences from each study, documenting the location and number of cord lesions, the degree of confidence in calling each lesion, and the presence of artifacts. The reference standard was determined by an unblinded consensus review of all sequences performed for each case, with lesions considered present if detected on two or more sequences. Lesion detection rates and conspicuity, false-positive findings, and reader confidence and artifact scores were compared for the sequences, and interreader agreement was assessed., Results: Eighty-three lesions were assessed. The mean true-positive lesion detection rate was 87% (95% CI, 79-93%) with MERGE and 67% (60-75%) with T2-weighted FSE, with interreader positive agreement scores of 74% and 75%, respectively. A greater number of false-positive findings were seen with MERGE for both the MS and control cases. Average confidence and artifact scores were similar for both sequences. Subjectively, lesions were more conspicuous in 21 cases with MERGE and four cases with T2-weighted FSE and were equally conspicuous in four cases., Conclusion: MERGE and T2-weighted FSE sequences are complementary. MERGE provided greater sensitivity for cord lesions whereas axial T2-weighted FSE provided improved lesion specificity. Further investigation is required to assess the clinical impact of MERGE in the diagnosis and management of MS.

Published
2012
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27. Plain radiograph assessment of spinal hardware.

Author

Venu V, Vertinsky AT, Malfair D, Chew JB, Shewchuk J, Heran MK, Graeb DA, and Street JT

Subjects
Humans, Internal Fixators, Radiation Dosage, Radiography, Spinal Fusion instrumentation, Postoperative Complications diagnostic imaging, Spinal Diseases diagnostic imaging, Spinal Diseases surgery, Spinal Fusion methods
Abstract

The frequency and variety of spinal instrumentation has increased tremendously over the past 100 years, and imaging plays an important role in evaluating the postoperative spine. Although assessment of spinal hardware often involves a multimodality approach, plain radiographs are the most commonly used modality, given accessibility, cost, relatively low radiation dose compared with computed tomography, and provision of positional information. An approach to assessment of plain radiographs of the postoperative spine is discussed, and examples of common postoperative complications are provided, including infection, hardware failure, incomplete fusion, and junctional failure., (© Thieme Medical Publishers.)

Published
2011
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28. Imaging in adult scoliosis: preoperative assessment and postoperative complications.

Author

Yeo JM, Vertinsky AT, Chew JB, Heran MK, Shewchuk J, Malfair D, Graeb DA, and Street JT

Subjects
Adult, Humans, Postoperative Complications diagnosis, Spinal Fusion instrumentation, Diagnostic Imaging, Scoliosis diagnosis, Scoliosis surgery, Spinal Fusion methods
Abstract

Adult scoliosis rates range from 2 to 32%. Surgery for scoliosis is common. Accurate and surgically relevant information should be provided to the referring surgeon from pre- and postoperative imaging. There are various methods to correct scoliosis surgically with the end points correction of the curve and relief of symptoms. This is achieved through the placement of spinal instrumentation with a goal of osseous fusion across the instrumented levels. There are many potential postoperative complications. The initial and postoperative imaging, types of surgery, and hardware are reviewed along with the common early and late complications with relevant illustrations., (© Thieme Medical Publishers.)

Published
2011
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29. Glomus tumour in the forearm: a case report and review of MRI findings.

Author

Lee S, Le H, Munk P, Malfair D, Lee ChH, and Clarkson P

Subjects
Aged, 80 and over, Biopsy, Diagnosis, Differential, Glomus Tumor pathology, Glomus Tumor surgery, Humans, Male, Soft Tissue Neoplasms pathology, Soft Tissue Neoplasms surgery, Forearm, Glomus Tumor diagnosis, Magnetic Resonance Imaging, Soft Tissue Neoplasms diagnosis
Abstract

Glomus tumours are uncommon benign neoplasms characterised by the proliferation of modified smooth muscle cells known as glomus cells. Glomus tumours are well described in the extremities, particularly in the sub-ungual region and MRI is well established as the investigation of choice. However, a significant proportion of glomus tumours are extra-digital, but the discussion of MRI findings of extra-digital tumours is limited and restricted to case reports. We present a case of a solitary painful forearm lesion in an 81-year-old man, and review the English literature on extra-digital glomus tumours documenting MR imaging features. Radiologists should be aware of the existence of these lesions, particularly in the setting of chronic pain and focal tenderness.

Published
2010
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30. An incidence of anteroinferior cerebellar artery/posteroinferior cerebellar artery anatomic variants penetrating the subarcuate fossa dura: operative technique and identification with 3-dimensional fast imaging employing steady-state acquisition magnetic resonance imaging.

Author

Warren DT, Warren MD, Malfair D, and Akagami R

Subjects
Adult, Basilar Artery surgery, Central Nervous System Vascular Malformations surgery, Cranial Fossa, Posterior anatomy & histology, Cranial Fossa, Posterior surgery, Craniotomy standards, Dura Mater surgery, Female, Humans, Male, Middle Aged, Neuronavigation methods, Neurosurgical Procedures methods, Neurosurgical Procedures standards, Petrous Bone surgery, Retrospective Studies, Time Factors, Basilar Artery abnormalities, Central Nervous System Vascular Malformations pathology, Craniotomy methods, Dura Mater anatomy & histology, Imaging, Three-Dimensional methods, Magnetic Resonance Imaging methods, Petrous Bone anatomy & histology
Abstract

Objective: This case series reports an incidence of anomalous vascular anatomy within the cerebellopontine angle. The relevant literature effectively describes techniques for mobilization yet underestimates the incidence. There has been no literature on the use of magnetic resonance imaging (MRI) to preoperatively identify this anatomic variant., Methods: We identify 8 cases of anomalous vascular anatomy within the cerebellopontine angle over a period of 6 years. They were uniformly identified through a retrosigmoid approach. Retrospective review of available 3-dimensional fast imaging employing steady-state acquisition (3D-FIESTA) sequences was performed. Intraoperative video capture of technique for mobilization was obtained. Institutional neurosurgical database review identified retrosigmoid craniotomies performed by the senior surgeon., Results: We identify 8 of 192 cases (4.2%) as having this anomalous vascular anatomy. This aberrant vascular loop resulted in subtotal resection in 3 of 8 cases (37.5%) and significant morbidity in 1 of 8 cases (12.5%). The retrospective review of the 3D-FIESTA MRI sequences positively identified this aberrant vascular course in 5 of 5 cases (100%). The digital video recording is of high quality and demonstrates proper technique for mobilization., Conclusion: The presence of this vessel creates the potential for technical difficulty and significant complications. We report the incidence and techniques of mobilization. This variant can potentially be identified on preoperative 3D-FIESTA MRI sequences. Knowledge of this anatomy may guide neurosurgeons in their case preparation.

Published
2010
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31. Radiographic evaluation of scoliosis: review.

Author

Malfair D, Flemming AK, Dvorak MF, Munk PL, Vertinsky AT, Heran MK, and Graeb DA

Subjects
Adolescent, Body Weights and Measures, Humans, Magnetic Resonance Imaging, Postural Balance, Radiographic Image Enhancement, Reproducibility of Results, Scoliosis pathology, Scoliosis surgery, Severity of Illness Index, Scoliosis diagnostic imaging
Published
2010
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32. Radiographic evaluation of scoliosis: self-assessment module.

Author

Malfair D, Flemming AK, Dvorak MF, Munk PL, Vertinsky AT, Heran MK, and Graeb DA

Subjects
Adolescent, Child, Humans, Magnetic Resonance Imaging, Postural Balance, Radiographic Image Enhancement, Scoliosis etiology, Scoliosis physiopathology, Scoliosis diagnostic imaging
Abstract

Objective: The educational objectives for this self-assessment module are for the participant to exercise, self-assess, and improve his or her understanding of evaluation of scoliosis using radiography., Conclusion: The solutions to the questions in this activity review the imaging characteristics of radiologic evaluation of scoliosis.

Published
2010
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33. SKyphoplasty.

Author

Rashid R, Munk PL, Heran M, Malfair D, and Chiu O

Subjects
Humans, Bone Cements therapeutic use, Spinal Cord Compression surgery, Spinal Fractures surgery, Vertebroplasty methods
Abstract

Objective: SKyphoplasty is a new method of percutaneous spinal augmentation. Despite its limited availability in the United States, SKyphoplasty has experienced considerable growth in recent years. In this article, we aim to provide a stepwise documentation of the technique, with brief reference to the 2 established methods, vertebroplasty and kyphoplasty., Conclusion: Experience with SKyphoplasty is relatively limited, and little information has appeared in the literature to support its theoretical benefits. After review of previously published material, an audit of our institutional experience, and discussion with other practioners who perform this procedure, it would appear that pain relief by using this device is at best similar to that of conventional vertebroplasty and kyphoplasty. There was no evidence of height restoration in our patient population, an advantage that has been brought into question.

Published
2009
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34. Magnetic resonance imaging appearance of partial latissimus dorsi muscle tendon tear.

Author

Le HB, Lee ST, Lane MD, Munk PL, Blachut PA, and Malfair D

Subjects
Adult, Humans, Male, Back Injuries pathology, Magnetic Resonance Imaging, Muscle, Skeletal injuries, Muscle, Skeletal pathology, Tendon Injuries pathology
Abstract

There is still a paucity of information about the clinical presentation, treatment and imaging findings of latissimus muscle tears. Only one study has specifically described the magnetic resonance imaging (MRI) features of latissimus tendon tears. We describe a case of a high-grade tear in the latissimus muscle tendon in an active water skier with no significant prior medical history. MRI demonstrated at least a 50% tear of the latissimus tendon, manifesting as increased signal intensity on T2-weighted sequences and surrounding edema, as well as a diminutive tendon at the humeral insertion.

Published
2009
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35. Imaging features of chest wall gossypiboma.

Author

Le HB, Lee S, Malfair D, and Munk PL

Subjects
Female, Humans, Microscopy, Acoustic, Young Adult, Foreign Bodies diagnostic imaging, Foreign Bodies etiology, Surgical Sponges adverse effects, Thoracic Injuries diagnostic imaging, Thoracic Injuries etiology
Published
2009
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36. Combined cementoplasty and radiofrequency ablation in the treatment of painful neoplastic lesions of bone.

Author

Munk PL, Rashid F, Heran MK, Papirny M, Liu DM, Malfair D, Badii M, and Clarkson PW

Subjects
Adult, Aged, Aged, 80 and over, Combined Modality Therapy, Female, Humans, Male, Middle Aged, Pain etiology, Spinal Neoplasms complications, Treatment Outcome, Bone Cements therapeutic use, Catheter Ablation methods, Lumbar Vertebrae surgery, Pain prevention & control, Spinal Neoplasms therapy, Thoracic Vertebrae surgery, Vertebroplasty methods
Abstract

Purpose: To assess the safety and effectiveness of combined radiofrequency (RF) ablation and cementoplasty in the treatment of painful neoplastic lesions of bone., Materials and Methods: The authors performed a retrospective analysis of 25 combined treatments comprising RF ablation followed by injection of polymethylmethacrylate cement performed in 19 patients during a 22-month period. Patients ranged in age from 42 to 82 years (mean, 58.9 years) and included five women and 14 men. Eleven vertebrae (eight lumbar and three thoracic), nine acetabulae, three sacra, one pubis, and one humerus were treated with a total of 36 RF ablations (in several instances, overlapping ablations were used). The location of the primary neoplasm, lesion size, pain before and after the procedure (as determined with a 10-point visual analog scale [VAS]), number of RF treatments, type of device used for cementoplasty, RF time, cement volume, and extravasation were documented., Results: A total of 25 combined RF ablations and cementoplasties were performed. The technical success rate was 100% (25 of 25 treatments). There were seven minor complications: six limited cement extravasations and a transient thermal nerve injury. The mean RF time was 9.1 minutes (range, 6-12 minutes). The mean cement volume injected was 6.1 mL (range, 0.8-16 mL). The mean preprocedure pain (as measured with a VAS) was 7.9 (range, 7.0-9.0) and the mean posttreatment pain was 4.2 (range, 0-6); the difference was statistically significant (mean score, 4.08; 95% confidence interval: 3.92, 4.87; P < .0001) using a paired t test., Conclusions: Combined RF ablation and cementoplasty appears to be safe and effective in the treatment of painful neoplastic lesions of bone.

Published
2009
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37. Vertebroplasty for vertebral compression fractures secondary to Cushing's syndrome induced by an ACTH-producing bronchial carcinoid tumour.

Author

Rashid F, Riccio SA, Munk PL, Malfair D, and Heran MK

Subjects
ACTH Syndrome, Ectopic blood, ACTH Syndrome, Ectopic diagnosis, Adrenocorticotropic Hormone blood, Adult, Bone Cements, Carcinoid Tumor blood, Carcinoid Tumor diagnosis, Carcinoid Tumor surgery, Cushing Syndrome blood, Cushing Syndrome diagnosis, Diagnosis, Differential, Female, Fractures, Compression blood, Fractures, Compression etiology, Humans, Hydrocortisone blood, Lumbar Vertebrae surgery, Lung Neoplasms blood, Lung Neoplasms diagnosis, Lung Neoplasms surgery, Osteoporosis diagnosis, Osteoporosis etiology, Osteoporosis surgery, Pneumonectomy, Resins, Synthetic administration & dosage, Spinal Fractures blood, Spinal Fractures etiology, Thoracic Vertebrae surgery, ACTH Syndrome, Ectopic complications, Carcinoid Tumor metabolism, Cushing Syndrome complications, Fractures, Compression surgery, Lumbar Vertebrae injuries, Lung Neoplasms metabolism, Spinal Fractures surgery, Thoracic Vertebrae injuries, Vertebroplasty methods
Abstract

Adrenocorticotropic hormone (ACTH)-producing bronchial carcinoid tumours are a rare cause of Cushing's syndrome. Cushing's syndrome is frequently complicated by osteoporosis, which results in an increased tendency for the development of vertebral compression fractures. Percutaneous vertebroplasty has been shown to be an effective treatment option in the setting of painful osteoporotic compression fractures refractory to conservative therapies. We report a case where vertebroplasty was performed on a 36-year-old woman with osteoporosis and compression fractures secondary to hypercorticolism. A bronchial carcinoid tumour was found to be the source of excess ACTH production. Three-level percutaneous vertebroplasty resulted in a marked improvement in pain.

Published
2009

39. Radiofrequency ablation of solitary eosinophilic granuloma of bone.

Author

Munk PL, Malfair D, Rashid F, and Torreggiani WC

Subjects
Adolescent, Child, Female, Humans, Radiography, Treatment Outcome, Catheter Ablation methods, Eosinophilic Granuloma diagnostic imaging, Eosinophilic Granuloma surgery, Femur diagnostic imaging, Femur surgery, Ileum diagnostic imaging, Ileum surgery
Published
2008
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40. Magnetic resonance imaging of the ankle at 3.0 Tesla and 1.5 Tesla in human cadaver specimens with artificially created lesions of cartilage and ligaments.

Author

Bauer JS, Barr C, Henning TD, Malfair D, Ma CB, Steinbach L, and Link TM

Subjects
Aged, Cadaver, Female, Humans, Male, Radiation Dosage, Sensitivity and Specificity, Ankle Injuries pathology, Cartilage injuries, Cartilage pathology, Image Enhancement methods, Ligaments injuries, Ligaments pathology, Magnetic Resonance Imaging methods
Abstract

Purpose: To compare magnetic resonance imaging of the ankle joint at 1.5 Tesla (T) and 3.0 T in the assessment of cartilage and ligament pathology in fresh human cadaver specimens., Materials and Methods: The study was performed in line with institutional and legislative requirements; all donors had dedicated their body for educational and research purposes before death. Thirteen fresh human cadaver ankle joints were imaged at 1.5 T and 3.0 T using an optimized clinical ankle protocol consisting of T1-weighted (T1-w), fat-saturated (fs) T2-w, and short tau inversion recovery fast spinecho (FSE) sequences. For dedicated cartilage imaging, fs-intermediate (IM)-w FSE, fs-spoiled gradient echo, and balanced free precession steady state sequences were acquired. Artificial cartilage and ligament lesions were created in 6 and 5 specimens, respectively. MR imaging was repeated in those ankles. Four radiologists independently assessed pathology in all image datasets. Macroscopic findings after dissection served as a reference standard., Results: Sensitivities and ROC-values were higher at 3.0 T for detecting cartilage pathology (sensitivity up to 0.71 at 3.0 T vs. 0.49 at 1.5 T; AZ up to 0.88 vs. 0.74; both differences P < 0.05) and highest for the fs-IM FSE sequence at 3.0 T. Average sensitivity for detecting ligament pathology was higher at 3.0 T (0.69 vs. 0.50; P < 0.05). Specificity was high among all protocols and both field strengths for assessing ligament and cartilage pathology (>0.95)., Conclusion: Compared with 1.5-T imaging, the 3.0-T imaging of the ankle joint at improved diagnostic performance in assessing cartilage significantly and there was a higher sensitivity for assessing ligamentous pathology.

Published
2008
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41. Therapeutic and diagnostic joint injections.

Author

Malfair D

Subjects
Adrenal Cortex Hormones administration & dosage, Anesthetics administration & dosage, Ankle Joint diagnostic imaging, Contrast Media administration & dosage, Elbow Joint diagnostic imaging, Hip Joint diagnostic imaging, Humans, Shoulder Joint diagnostic imaging, Wrist Joint diagnostic imaging, Arthrography methods, Fluoroscopy methods, Injections, Intra-Articular methods, Joint Diseases diagnostic imaging, Joint Diseases drug therapy, Magnetic Resonance Imaging methods, Tomography, X-Ray Computed methods
Abstract

Joint injections remain a valuable modality in the detection and treatment of intra-articular pathology. Over the past several decades, various diagnostic and therapeutic indications for joint injections have been developed. Imaging guidance for joint injection generally increases accuracy in joint aspirations and diagnostic blocks. Confirming intra-articular placement with steroid injections improves efficacy and reduces local complications. Administering intra-articular contrast can improve the diagnostic performance of CT and MR imaging in many circumstances. This article focuses on the rationale for injections at different sites and describes different fluoroscopic approaches for common joints.

Published
2008
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42. MR imaging of the ankle at 3 Tesla and 1.5 Tesla: protocol optimization and application to cartilage, ligament and tendon pathology in cadaver specimens.

Author

Barr C, Bauer JS, Malfair D, Ma B, Henning TD, Steinbach L, and Link TM

Subjects
Aged, Aged, 80 and over, Cadaver, Cartilage, Articular pathology, Female, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Ligaments pathology, Male, Middle Aged, ROC Curve, Statistics, Nonparametric, Tendons pathology, Ankle Joint pathology, Magnetic Resonance Imaging methods
Abstract

The objective of this study was to optimize ankle joint MR imaging in volunteers at 1.5 Tesla (T) and 3.0 T, and to compare these optimized sequences concerning image quality and performance in assessing cartilage, ligament and tendon pathology in fresh human cadaver specimens. Initially our clinical ankle protocol consisting of T1-weighted (-w), fat-saturated (fs) T2-w, and short tau inversion-recovery fast spinecho (FSE) sequences was optimized at 1.5 T and 3.0 T by two radiologists. For dedicated cartilage imaging, fs-intermediate (IM)-w FSE, fs spoiled gradient echo, and balanced free-precession steady-state sequences were optimized. Using the optimized sequences, thirteen cadaver ankle joints were imaged. Four radiologists independently assessed these images concerning image quality and pathology. All radiologists consistently rated image quality higher at 3.0 T (all sequences p<0.05). For detecting cartilage pathology, diagnostic performance was significantly higher at 3.0 T (ROC-values up to 0.93 vs. 0.77; p<0.05); the fs-IM FSE sequence showed highest values among the different sequences. Average sensitivity for detecting tendon pathology was 63% at 3.0 T vs. 41% at 1.5 T and was significantly higher at 3.0 T for 2 out of 4 radiologists (p<0.05). Compared to 1.5 T, imaging of the ankle joint at 3.0 T significantly improved image quality and diagnostic performance in assessing cartilage pathology.

Published
2007
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43. Imaging the degenerative diseases of the lumbar spine.

Author

Malfair D and Beall DP

Subjects
Contrast Media, Diagnosis, Differential, Humans, Intervertebral Disc pathology, Lumbar Vertebrae pathology, Magnetic Resonance Imaging methods, Spinal Diseases diagnosis
Abstract

Degenerative changes of the spine may involve the disc space, the facet joints, or the supportive and surrounding soft tissues. MR imaging is ideally suited for delineating the presence, extent, and complications of degenerative spinal disease. Other imaging modalities such as radiography, myelography, and CT may provide complimentary information in selected cases. Percutaneous procedures may be used to confirm that a morphologic abnormality is the source of symptoms. Correlation with clinical and electrophysiologic data is also helpful for accurate diagnosis. Combining the information obtained from imaging studies with the patient's clinical presentation is mandatory for determining the appropriate patient management strategy, especially true in patients afflicted with any condition directly attributed to the degenerative processes of the spine.

Published
2007
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44. Magnetic resonance arthrography.

Author

Osinski T, Malfair D, and Steinbach L

Subjects
Cartilage diagnostic imaging, Collateral Ligaments diagnostic imaging, Gadolinium administration & dosage, Hip Joint diagnostic imaging, Humans, Image Enhancement, Joint Loose Bodies diagnostic imaging, Menisci, Tibial diagnostic imaging, Radiopharmaceuticals administration & dosage, Rotator Cuff pathology, Rotator Cuff Injuries, Rupture, Arthrography methods, Magnetic Resonance Imaging methods, Shoulder Joint pathology
Abstract

For decades, fluoroscopic arthrography was the only method available to image a joint with contrast enhancement. Advances in CT led to the natural development of CT arthrography. Development of MRI and its capability for multiplanar imaging led to direct magnetic resonance arthrography (MRA). This technique has been performed since 1987 and has surpassed CT arthrography in popularity in the United States. Indirect MRA developed subsequently to offer a less invasive alternative. This article presents an overview of direct MRA and addresses joint-specific issues regarding direct MRA. An overview of indirect MRA also is provided.

Published
2006
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45. Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis.

Author

Jijon HB, Churchill T, Malfair D, Wessler A, Jewell LD, Parsons HG, and Madsen KL

Subjects
Animals, Benzamides pharmacology, Chronic Disease, Colitis immunology, Disease Models, Animal, Energy Metabolism drug effects, Enzyme Inhibitors pharmacology, Inflammatory Bowel Diseases drug therapy, Inflammatory Bowel Diseases enzymology, Inflammatory Bowel Diseases immunology, Interferon-gamma metabolism, Interleukin-10 genetics, Intestinal Absorption physiology, Intestinal Mucosa metabolism, Mice, Mice, Inbred Strains, Mice, Knockout, Neutrophils immunology, Nitric Oxide Synthase metabolism, Nitric Oxide Synthase Type II, Poly (ADP-Ribose) Polymerase-1, Poly(ADP-ribose) Polymerases, Tumor Necrosis Factor-alpha metabolism, Tyrosine analogs & derivatives, Tyrosine biosynthesis, Colitis drug therapy, Colitis enzymology, Proteins antagonists & inhibitors, Proteins metabolism
Abstract

Crohn's disease is a chronic disease characterized by oxidant-induced tissue injury and increased intestinal permeability. A consequence of oxidative damage is the accumulation of DNA strand breaks and activation of poly(ADP-ribose) polymerase (PARP), which subsequently catalyzes ADP-ribosylation of target proteins. In this study, we assessed the role of PARP in the colitis seen in interleukin (IL)-10 gene-deficient mice. IL-10 gene-deficient mice demonstrated significant alterations in colonic cellular energy status in conjunction with increased permeability, proinflammatory cytokine release, and nitrosative stress. After 14 days of treatment with the PARP inhibitor 3-aminobenzamide, IL-10 gene-deficient mice demonstrated normalized colonic permeability; reduced tumor necrosis factor-alpha and interferon-gamma secretion, inducible nitric oxide synthase expression, and nitrotyrosine levels; and significantly attenuated inflammation. Time course studies demonstrated that 3-aminobenzamide rapidly altered cellular metabolic activity and decreased cellular lactate levels. This was associated with normalization of colonic permeability and followed by a downregulation of proinflammatory cytokine release. Our data demonstrate that inhibition of PARP activity results in a marked improvement of colonic inflammatory disease and a normalization of cellular metabolic function and intestinal permeability.

Published
2000
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46. Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora.

Author

Madsen KL, Malfair D, Gray D, Doyle JS, Jewell LD, and Fedorak RN

Subjects
Animals, Colon microbiology, Colon pathology, Culture Techniques, Germ-Free Life, Ileum microbiology, Ileum pathology, Inflammatory Bowel Diseases pathology, Interleukin-10 deficiency, Intestinal Mucosa pathology, Mice, Mice, Inbred Strains, Permeability, Reference Values, Sensitivity and Specificity, Colon metabolism, Cytokines metabolism, Ileum metabolism, Inflammatory Bowel Diseases genetics, Interleukin-10 genetics, Intestinal Mucosa metabolism, Intestinal Mucosa microbiology
Abstract

The normal intestinal epithelium provides a barrier relatively impermeable to luminal constituents. However, patients with inflammatory bowel disease experience enhanced intestinal permeability that correlates with the degree of injury. IL-10 gene-deficient mice were studied to determine whether increased intestinal permeability occurs as a primary defect before the onset of mucosal inflammation or is secondary to mucosal injury. At 2 weeks of age, IL-10 gene-deficient mice show an increase in ileal and colonic permeability in the absence of any histological injury. This primary permeability defect is associated with increased mucosal secretion of interferon-gamma and tumor necrosis factor-alpha, and does not involve an increase in nitric oxide synthase activity. Colonic permeability remains elevated as inflammation progresses, while ileal permeability normalizes by 6 weeks of age. IL-10 gene-deficient mice raised under germ-free conditions have no inflammation, and demonstrate normal permeability and cytokine levels. This data suggests that the intestinal permeability defect in IL-10 gene-deficient mice occurs due to a dysregulated immune response to normal enteric microflora and, furthermore, this permeability defect exists prior to the development of mucosal inflammation.

Published
1999
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