13 results on '"Malekpour, N."'
Search Results
2. Risk factor investigation for cardiovascular health through WHO STEPS approach in Ardabil, Iran
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Nadirmohammadi M, Zohouri A, Danehzan M, Mortezazadeh A, Elham Kharazmi, Nasimidoust R, Masoud Babaei, Soltanmohammadzadeh Ms, Mashhadi-Abdollahi H, Jafar Bashiri, Khosravi O, Homayoun Sadeghi-Bazargani, Hekmat S, Malekpour N, Shaker A, Hosseingolizadeh Gh, Jafarzadeh H, and Mahdi Fallah
- Subjects
Male ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Endocrinology, Diabetes and Metabolism ,Blood Pressure ,Iran ,Body Mass Index ,Risk Factors ,Surveys and Questionnaires ,Prevalence ,Medicine ,Pharmacology (medical) ,Original Research ,Smoking ,cardiovascular health ,Hematology ,General Medicine ,Middle Aged ,Risk factor (computing) ,Smoking epidemiology ,Cardiovascular Diseases ,Noncommunicable disease ,Hypertension ,Regression Analysis ,Female ,Cardiology and Cardiovascular Medicine ,Risk assessment ,Stepwise approach ,Noncoomunicable diseases ,Adult ,medicine.medical_specialty ,Adolescent ,noncommunicable diseases ,Cardiovascular health ,Who steps ,Physical activity ,Risk Assessment ,Young Adult ,Environmental health ,Humans ,Obesity ,Exercise ,Life Style ,business.industry ,cardio-vascular health ,Public Health, Environmental and Occupational Health ,Diet ,Vascular Health and Risk Management ,Socioeconomic Factors ,lcsh:RC666-701 ,WHO STEPS ,Physical therapy ,business - Abstract
H Sadeghi-Bazargani1,2, H Jafarzadeh3, M Fallah4, S Hekmat3, J Bashiri3, GH Hosseingolizadeh3, MS Soltanmohammadzadeh3, A Mortezazadeh3, A Shaker3, M Danehzan3, A Zohouri3, O Khosravi3, R Nasimidoust3, N Malekpour3, E Kharazmi4, M Babaei3, M Nadirmohammadi3, H Mashhadi-Abdollahi51Neuroscience Research Center, 2Statistics and Epidemiology Department, Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran; 3Public Health Department, Ardabil University of Medical Sciences, Ardabil, Iran; 4Tampere School of Public Health, University of Tampere, Tampere, Finland; 5National Public Health Management Center (NPMC), Tabriz University of Medical Sciences, Tabriz, IranObjectives: Reliable evidence is the keystone for any noncommunicable disease (NCD) prevention plan to be initiated. In this study we carried out a risk factor investigation based on the WHO Stepwise approach to Surveillance (STEPS).Methods: The study was conducted out on 1000 adults between 15 and 64 years of age living in Ardabil province, north-west Iran during 2006, based on the WHO STEPS approach to surveillance of risk factors for NCD. At this stage only the first and second steps were carried out. Data were collected through standard questionnaires and methods analyzed using STATA version 8 statistical software package.Results: 29.0% of men and 2.6% of women were current daily tobacco smokers. The mean number of manufactured cigarettes smoked per day was 18.9 among current daily smokers. Smoking was most prevalent among men of low-income families and those of lower education. The mean body mass index (BMI) was 26.6 kg/m2, and was significantly correlated with systolic blood pressure. 58.9% were overweight or obese; 18.0% had raised blood pressure and 3.7% had isolated systolic hypertension. The mean number of servings of fruit consumed per day was 1.1; 33.1% had low levels of activity. Combined risk factor analysis showed that 4.1% of participants were in the low-risk group (up to 5.1% among men and 3.2% among women). Those in the high-risk group comprised 25.6% in the 25- to 44-year age group and 49.7% in the 45- to 64-year age group. Mean BMI increased by age in both sexes at least at the first three decades of adult life.Conclusion: Based on observed status of risk for cardiovascular health, burden of cardiovascular diseases is expected to increase if an effective prevention strategy is not undertaken.Keywords: cardiovascular health, noncommunicable diseases, WHO STEPS, smoking, obesity, physical activity
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- 2011
3. Risk factor investigation for cardiovascular health through WHO STEPS approach in Ardabil, Iran.
- Author
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Sadeghi-Bazargani, H., Jafarzadeh, H., Fallah, M., Hekmat, S., Bashiri, J., Hosseingolizadeh, G. H., Soltanmohammadzadeh, M. S., Mortezazadeh, A., Shaker, A., Danehzan, M., Zohouri, A., Khosravi, O., Nasimidoust, R., Malekpour, N., Kharazmi, E., Babaei, M, Nadirmohammadi, M., and Mashhadi-Abdollahi, H.
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- 2011
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4. Diagnostic accuracy of fine needle aspiration cytology: Comparison of results in Tabriz Imam Khomeini Hospital and Shiraz University of Medical Sciences
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Hashemzadeh, S. H., Kumar, P. V., Malekpour, N., Zahra Sadat Hashemi, Fattahi, F., and Malekpour, F.
5. The phase 2 study of '(TOX) preoperative chemotherapy' response rate and side effects in [locally advanced operable gastric adenocarcinoma] patients with docetaxel, oxaliplatin and capcitabine
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Yahyazadeh-Jabbari, S. -H, Malekpour, N., Salmanian, B., Foodazi, H., Masoud Salehi, and Noorizadeh, F.
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Chemotherapy ,Preoperative period ,Stomach neoplasm ,Clinical Trial ,Neoadjuvant Therapy - Abstract
Background Early stage gastric cancer diagnosis has ensued different approaches in resection strategies. In order to increase the proportion of cases which have undergone radical resection or have reduced the recurrence rate, different pre-operative treatments have introduced. Here, we have verified an active preoperative chemotherapeutic regimen in locally advanced gastric cancer patients. Methods Forty nine patients who have found eligible to enter this phase 2 trial have treated with oxaliplatin 100 mg/m2 IV, docetaxel 50 mg/m2 IV, plus capecitabine 625 mg/m2 PO (TOX). Clinical staging has been following the first 2 cycles of induction chemotherapy. Patients that have further undergone radical surgery, have evaluated for pathological response rate. Results Anemia (10.2%), nausea (10.2%) and vomiting (6.1%) were the most frequent grade 3 or 4 adverse effects. Regarding the pathologic staging, 6 patients (12.2%) had complete response (95% CI 3% to 21.4%), 18 of them (36.7%) had partial response (95% CI 23.2% to 50.2%), then 3 patients (6.1%) had stable disease (95% CI 0%-12.8%). Among the patients who had surgery, 22% had pathologic complete response. Conclusion Preoperative chemotherapeutic regimen of TOX seems to be an active and safe neoadjuvant therapy in non metastatic gastric cancer. It should further be considered with concurrent radiotherapy.
6. Comparison between the Efficacies of Modafinil and Citalopram in the Treatment of Major Depression.
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Rostami H, Safaei G, Norouzi S, Abdi L, and Malekpour N
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Introduction: Antidepressants are the most common treatment for major depression. Also, psychotherapy is used for the treatment of depression. Tricyclic antidepressants are among the most frequently used medications to treat depression, with many known side effects. Therefore, checking and replacing other suitable drugs is essential in order to reduce side effects. Thus, the present study aimed to compare the efficacy of Modafinil and Citalopram in the treatment of patients with major depressive disorder. Methods: This interventional study was performed in 2019 on 30 people aged 18 to 65 years who had been diagnosed with a major depressive disorder based on DSM-5 criteria as well as the Hamilton Depression Rating Scale (HDRS), on which they got a score above 25. Subjects were randomly divided into two groups: the first group received Modafinil tablets (200 mg once daily, in the morning) and the second group Citalopram (20-40 mg/day). A Chi-square test was used to analyze the qualitative findings, and an independent t-test was used to compare quantitative data. Results: The results showed that changes in HDRS score were significant over time (P <0.05). The mean difference in HDRS scores was significant in all stages among the study subjects (P <0.05). However, there were no significant differences in HDRS scores between groups in terms of gender, age, marital status, education, occupation, and economic status, either before treatment or three and six weeks after treatment. Conclusion: This was the first comparative study of Modafinil and Citalopram efficacy in treating patients with major depressive disorder. Larger-scale, longer-term clinical trials, including long-term discontinuation trials and placebo-controlled parallel treatment studies, are further necessary. Also, a larger sample size with a placebo comparison is recommended.
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- 2022
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7. Clinical features and tubulin folding cofactor E gene analysis in Iranian patients with Sanjad-Sakati syndrome.
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Aminzadeh M, Galehdari H, Shariati G, Malekpour N, and Ghandil P
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- Humans, Iran, Molecular Chaperones, Tubulin, Abnormalities, Multiple, Growth Disorders, Hypoparathyroidism, Intellectual Disability, Osteochondrodysplasias, Seizures
- Abstract
Objective: Permanent hypoparathyroidism can be presented as part of genetic disorders such as Sanjad-Sakati syndrome (also known as hypoparathyroidism-intellectual disability-dysmorphism), which is a rare autosomal recessive disorder. Our aim was to confirm the diagnosis of a group of patients with dysmorphism, poor growth, and hypoparathyroidism clinically labeled as Sanjad-Sakati syndrome and to identify for the first time the genetic variations on Iranian patients with the same ethnic origin., Methods: In this study, 29 cases from 23 unrelated Arab kindreds with permanent hypoparathyroidism and dysmorphism indicating Sanjad-Sakati syndrome were enrolled for 10 years in the southwest of Iran. The mutational analysis by direct sequencing of the tubulin folding cofactor E gene was performed for the patients and their families, as well as their fetuses using genomic DNA., Results: Twenty-eight out of 29 cases had parental consanguinity. Twenty-seven cases presented with hypocalcemia seizure and two were referred because of poor weight gain and were found to have asymptomatic hypocalcemia. The dysmorphic features, hypocalcemia in the setting of low to normal parathyroid hormone levels and high phosphorus led to the diagnosis of these cases. Sequencing analysis of the tubulin folding cofactor E gene revealed a homozygous 12-bp deletion (c.155-166del) for all patients. Following that, prenatal diagnosis was performed for eight families, and two fetuses with a homozygous 12-bp deletion were identified., Conclusion: These results make it much easier and faster to diagnose this syndrome from other similar dysmorphisms and also help to detect carriers, as well as prenatal diagnosis of Sanjad-Sakati syndrome in high-risk families in this population., (Copyright © 2018. Published by Elsevier Editora Ltda.)
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- 2020
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8. Identification of arylsulfatase B gene mutations and clinical presentations of Iranian patients with Mucopolysaccharidosis VI.
- Author
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Aminzadeh M, Malekpour N, and Ghandil P
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- Adult, Consanguinity, DNA genetics, DNA Mutational Analysis methods, Exons, Female, Humans, Iran, Male, Mucopolysaccharidosis VI enzymology, Mucopolysaccharidosis VI metabolism, Mutation genetics, N-Acetylgalactosamine-4-Sulfatase metabolism, N-Acetylgalactosamine-4-Sulfatase physiology, Phenotype, Sequence Analysis, DNA methods, Mucopolysaccharidosis VI genetics, N-Acetylgalactosamine-4-Sulfatase genetics
- Abstract
Background: Mucopolysaccharidosis (MPS) type VI, also known as Maroteaux-Lamy syndrome, is an autosomal recessive lysosomal storage disorder caused by a deficiency in arylsulfatase B (ARSB) enzyme. Our objectives were to investigate clinical phenotypes and performed molecular studies in Iranian patients with MPS VI, for the first time, in the southwestern Iran., Methods: We studied 14 cases from 10 unrelated kindreds with MPS VI that were enrolled during 8 years. The mutational analysis of coding and flanking regions of ARSB gene was performed for the patients and their families using genomic DNA from whole blood by direct sequencing., Results: All cases had parental consanguinity. Except one who had Fars ethnicity and presented with a very mild degree of coarse face, but normal otherwise, even near normal height, all were from Arab ethnicity with characteristic phenotypes including severe facial changes, cardiac involvement and dysostosis multiplex. Sequencing analysis of ARSB gene revealed four pathogenic homozygote mutations, including a novel nonsense mutation c.281C>A (p.Ser94X) in 9 patients, as well as, a known nonsense mutation c.753C>G (p.Try251X) in 3 cases, and two missense mutations c.904G>A (p.Gly302Arg) and c.454C>T (p.Arg152Trp) in two cases. The type of mutations affected the severity patient's phenotypes., Conclusions: These findings increased the genetic databases of Iranian patients with MPS VI and would be so much helpful for the high-risk families to speed the detection of carriers with accuracy and perform the prenatal test of disorder with cost-effective in this population., (Copyright © 2019. Published by Elsevier B.V.)
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- 2019
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9. Mutational analysis of ARSB gene in mucopolysaccharidosis type VI: identification of three novel mutations in Iranian patients.
- Author
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Malekpour N, Vakili R, and Hamzehloie T
- Abstract
Objectives: Mucopolysaccharidosis VI (MPS VI) or Maroteaux-Lamy syndrome is a rare metabolic disorder, resulting from the deficient activity of the lysosomal enzyme arylsulfatase B (ARSB). The enzymatic defect of ARSB leads to progressive lysosomal storage disorder and accumulation of glycosaminoglycan (GAG) dermatan sulfate (DS), which causes harmful effects on various organs and tissues and short stature. To date, more than 160 different mutations have been reported in the ARSB gene., Materials and Methods: Here, we analyzed 4 Iranian and 2 Afghan patients, with dysmorphism indicating MPS VI from North-east Iran. To validate the patients' type of MPS VI, urine mucopolysaccharide and leukocyte ARSB activity were determined. Meanwhile, genomic DNA was amplified for all 8 exons and flanking intron sequences of the ARSB gene to analyze the spectrum of mutations responsible for the disorder in all patients., Results: Abnormal excretion of DS and low leukocyte ARSB activity were observed in the urine samples of all 6 studied patients. In direct DNA sequencing, we detected four different homozygous mutations in different exons, three of which seem not to have been reported previously: p.H178N, p.H242R, and p.*534W. All three novel substitutions were found in patients with Iranian breed. We further detected the IVS5+2T>C mutation in Afghan siblings and four different homozygous polymorphisms, which have all been observed in other populations., Conclusion: results indicated that missense mutations were the most common mutations in the ARSB gene, most of them being distributed throughout the ARSB gene and restricted to individual families, reflecting consanguineous marriages., Competing Interests: The authors declare that they have no competing interests.
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- 2018
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10. The Survey of Double Robertsonian Translocation 13q; 14q in the Pedigree of 44; XX Woman: A Case Report.
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Malekpour N, Kormi SMA, Azadbakht M, Yousefi M, and Hasanzadeh-Nazar Abadi M
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Robertsonian translocations (RBTs) are associated with an increased risk of aneuploidy. Single RBT carriers are the most common balanced rearrangements among the carrier couples with the history of spontaneous abortions. However, double Robertsonian translocations (DRBTs), in which two balanced RBTs occur simultaneously, are extremely rare conditions. A 9-year-old mentally normal girl with multiple skeletal disorders was found to carry a balanced 13/14 RBT (45, XX, t(13q; l4q)). Three generations of her family, including her parents and her maternal grandparents were investigated for cytogenetic analysis. All of them were phenotypically normal. Her mother appeared in a peculiar karyotype of 44, XX, t (13q; 14q) ×2, while her father revealed a normal karyotype 46, XY. Chromosomal constitution of her grandparents showed that both of them carried this balanced reciprocal translocation (45, XY t (13q; 14q) as well as 45, XX, t (13q;14q)). Cytogenetic evaluations on the basis G-banding technique were performed for participants. Except the 9- year-old girl, all RBT carriers in this family appeared phenotypically normal, her skeletal disorders might not be due to chromosomal rearrangement. Meanwhile, all offsprings of 44, XX woman are obligatory carriers of this translocation, and should be candidates for prenatal diagnosis (PND) or preimplantation genetic diagnosis (PGD), for their future pregnancies., Competing Interests: Authors declared no conflict of interest.
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- 2017
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11. Design, formulation, and physicochemical evaluation of periodontal propolis mucoadhesive gel.
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Aslani A and Malekpour N
- Abstract
Background: Periodontitis is a disease of tooth supporting tissues, and Gram-negative Bacteria are the main cause of this. Propolis has antibacterial, anti-inflammatory, and antioxidant effects due to its high polyphenol and flavonoids content. The aim of this study is the formulation of a mucoadhesive gel containing concentrated extract of propolis for treatment of periodontitis., Materials and Methods: Formulations containing carbopol 940, sodium carboxymethylcellulose (NaCMC), hydroxypropyl methylcellulose K4M, and propolis extract were prepared. Among ten prepared formulations, five formulations had acceptable and proper physical appearance and uniformity; thus, they were selected for physicochemical tests (centrifugal, thermal change, cooling and heating, freeze and thaw, thermal stress, and pH evaluation), quantification of flavonoids, viscosity, mucoadhesion, drug release, and syringeability tests. We investigated the antibacterial activity of F
10 (carbopol 940 1%, NaCMC 3%) against Porphyromonas gingivalis using the disk diffusion method., Results: Phenolic content was measured 39.02 ± 3.24 mg/g of concentrated extract as gallic acid and flavonoid content was determined 743.28 ± 12.1 mg/g of concentrated extract as quercetin. Highest viscosity (3700 cps) and mucoadhesion (21 MPa) were seen in F10 . Study of release profile in F10 also revealed that propolis could release from this system in more than 7 days. All of the five selected formulations had ease of syringeability in 21-gauge needle for drug delivery into periodontal pocket. In the disk diffusion method, F10 produced significant growth inhibition zones against P. gingivalis ., Conclusion: Controlled release of drug into periodontal pocket helps effective treatment and recovery, higher persistence and reduces drug use frequency. Increase of carbopol 940 leads to viscosity and mucoadhesion elevation and accordingly decreases of release rate. F10 was the best formulation because of highest viscosity and mucoadhesion and lowest release rate. It had efficient function in treatment of periodontitis, so we recommend it for clinical evaluation., Competing Interests: The authors of this manuscript declare that they have no conflicts of interest, real or perceived, financial or non-financial in this article.- Published
- 2016
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12. The Phase 2 Study of "(TOX) Preoperative Chemotherapy" Response Rate and Side Effects in [Locally Advanced Operable Gastric Adenocarcinoma] Patients With Docetaxel, Oxaliplatin and Capcitabine.
- Author
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Yahyazadeh-Jabbari SH, Malekpour N, Salmanian B, Foodazi H, Salehi M, and Noorizadeh F
- Abstract
Background: Early stage gastric cancer diagnosis has ensued different approaches in resection strategies. In order to increase the proportion of cases which have undergone radical resection or have reduced the recurrence rate, different pre-operative treatments have introduced. Here, we have verified an active preoperative chemotherapeutic regimen in locally advanced gastric cancer patients., Methods: Forty nine patients who have found eligible to enter this phase 2 trial have treated with oxaliplatin 100 mg/m2 IV, docetaxel 50 mg/m2 IV, plus capecitabine 625 mg/m2 PO (TOX). Clinical staging has been following the first 2 cycles of induction chemotherapy. Patients that have further undergone radical surgery, have evaluated for pathological response rate., Results: Anemia (10.2%), nausea (10.2%) and vomiting (6.1%) were the most frequent grade 3 or 4 adverse effects. Regarding the pathologic staging, 6 patients (12.2%) had complete response (95% CI 3% to 21.4%), 18 of them (36.7%) had partial response (95% CI 23.2% to 50.2%), then 3 patients (6.1%) had stable disease (95% CI 0%-12.8%). Among the patients who had surgery, 22% had pathologic complete response., Conclusion: Preoperative chemotherapeutic regimen of TOX seems to be an active and safe neoadjuvant therapy in non metastatic gastric cancer. It should further be considered with concurrent radiotherapy.
- Published
- 2013
13. Epidemiology of minor and moderate burns in rural Ardabil, Iran.
- Author
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Sadeghi-Bazargani H, Mohammadi R, Svanstrom L, Ekman R, Arshi S, Hekmat S, Malekpour N, and Mashoufi M
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- Accidents, Home prevention & control, Accidents, Home statistics & numerical data, Adolescent, Adult, Age Factors, Aged, Burns etiology, Burns prevention & control, Child, Child, Preschool, Cooking, Female, Heating, Hot Temperature, Humans, Incidence, Infant, Iran epidemiology, Male, Middle Aged, Pilot Projects, Rural Population, Sex Factors, Surveys and Questionnaires, Tea, Water, Young Adult, Burns epidemiology
- Abstract
Epidemiology of minor burns is not well defined worldwide. The aim of this study was to examine epidemiological features of minor and moderate burn events that could be beneficial for prevention purposes. The study was conducted in Ardabil province in north-west Iran in 2005-2006. A total of 1700 minor and moderate burns were studied using a pretested questionnaire. Using the SAS 9.1 statistical program analyses were made. Females comprised the majority of cases (n=1000, 58.8%) and children, aged six and younger, made up 36.4% of burn victims. The majority of burns were caused by hot water and tea with the primary containers being kettles in 37.8%, cups or glasses in 24.2%, pots in 13.6% and samovars in 7.9%. Samovars, gas stoves, valors and picnic gas stoves were the primary heating devices involved in burns. In 56% of the cases, overturning of liquid containers was the primary injury mechanism of scalds. 43% had a second-degree burn with a mean total body surface area of 1.3%. This study provides possible beneficial information for burn prevention in the Ardabil area and other similar settings., (2009 Elsevier Ltd and ISBI. All rights reserved.)
- Published
- 2010
- Full Text
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