26 results on '"Maldonado‐Araque, Cristina"'
Search Results
2. Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study)
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Valdés, Sergio, Doulatram-Gamgaram, Viyey, Maldonado-Araque, Cristina, Lago-Sampedro, Ana, García-Escobar, Eva, García-Serrano, Sara, García-Vivanco, Marta, Garrido Juan, Luis, Theobald, Mark Richard, Gil, Victoria, Martín-Llorente, Fernando, Ocon, Pilar, Calle-Pascual, Alfonso, Castaño, Luis, Delgado, Elías, Menendez, Edelmiro, Franch-Nadal, Josep, Gaztambide, Sonia, Girbés, Joan, Chaves, F Javier, Galán-García, José L, Aguilera-Venegas, Gabriel, Gutierrez-Repiso, Carolina, Fernández-García, José Carlos, Colomo, Natalia, Soriguer, Federico, García-Fuentes, Eduardo, and Rojo-Martínez, Gemma
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- 2022
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3. Association between long term exposure to particulate matter and incident hypertension in Spain
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Doulatram-Gamgaram, Viyey, Valdés, Sergio, Maldonado-Araque, Cristina, Lago-Sampedro, Ana, Badía-Guillén, Rocío, García-Escobar, Eva, García-Serrano, Sara, García-Vivanco, Marta, Garrido, Juan Luis, Theobald, Mark Richard, Gil, Victoria, Martín-Llorente, Fernando, Calle-Pascual, Alfonso, Bordiu, Elena, Castaño, Luis, Delgado, Elías, Franch-Nadal, Josep, Chaves, F. Javier, Montanya, Eduard, Galán-García, José Luis, Aguilera-Venegas, Gabriel, Soriguer, Federico, and Rojo-Martínez, Gemma
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- 2021
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4. Association between exposure to air pollution and blood lipids in the general population of Spain.
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Valdés, Sergio, Doulatram‐Gamgaram, Viyey, Maldonado‐Araque, Cristina, García‐Escobar, Eva, García‐Serrano, Sara, Oualla‐Bachiri, Wasima, García‐Vivanco, Marta, Garrido, Juan Luis, Gil, Victoria, Martín‐Llorente, Fernando, Calle‐Pascual, Alfonso, Castaño, Luis, Delgado, Elías, Menéndez, Edelmiro, Franch‐Nadal, Josep, Gaztambide, Sonia, Girbés, Joan, Chaves, F. Javier, Galán‐García, José L., and Aguilera‐Venegas, Gabriel
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AIR pollution ,BLOOD lipids ,AIR pollutants ,PARTICULATE matter ,AIR quality - Abstract
Background and Aims: We aimed to assess the associations of exposure to air pollutants and standard and advanced lipoprotein measures, in a nationwide sample representative of the adult population of Spain. Methods: We included 4647 adults (>18 years), participants in the national, cross‐sectional, population‐based di@bet.es study, conducted in 2008–2010. Standard lipid measurements were analysed on an Architect C8000 Analyzer (Abbott Laboratories SA). Lipoprotein analysis was made by an advanced 1H‐NMR lipoprotein test (Liposcale®). Participants were assigned air pollution concentrations for particulate matter <10 μm (PM10), <2.5 μm (PM2.5) and nitrogen dioxide (NO2), corresponding to the health examination year, obtained by modelling combined with measurements taken at air quality stations (CHIMERE chemistry‐transport model). Results: In multivariate linear regression models, each IQR increase in PM10, PM2.5 and NO2 was associated with 3.3%, 3.3% and 3% lower levels of HDL‐c and 1.3%, 1.4% and 1.1% lower HDL particle (HDL‐p) concentrations (p <.001 for all associations). In multivariate logistic regression, there was a significant association between PM10, PM2.5 and NO2 concentrations and the odds of presenting low HDL‐c (<40 mg/dL), low HDL‐p (
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- 2024
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5. Association between exposure to air pollution and blood lipids in the general population of Spain
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Valdés, Sergio, primary, Doulatram‐Gamgaram, Viyey, additional, Maldonado‐Araque, Cristina, additional, García‐Escobar, Eva, additional, García‐Serrano, Sara, additional, Oualla‐Bachiri, Wasima, additional, García‐Vivanco, Marta, additional, Garrido, Juan Luis, additional, Gil, Victoria, additional, Martín‐Llorente, Fernando, additional, Calle‐Pascual, Alfonso, additional, Castaño, Luis, additional, Delgado, Elías, additional, Menéndez, Edelmiro, additional, Franch‐Nadal, Josep, additional, Gaztambide, Sonia, additional, Girbés, Joan, additional, Chaves, F. Javier, additional, Galán‐García, José L., additional, Aguilera‐Venegas, Gabriel, additional, Vallvé, Joan Carles, additional, Amigó, Núria, additional, Guardiola, Montse, additional, Ribalta, Josep, additional, and Rojo‐Martínez, Gemma, additional
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- 2023
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6. Amyloid Goiter in a Patient with Cystic Fibrosis
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Omiste, Antonio, Maldonado-Araque, Cristina, Olveira, Casilda, Mellado, Jose, and Olveira, Gabriel
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- 2015
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7. Usefulness of Muscle Ultrasonography in the Nutritional Assessment of Adult Patients with Cystic Fibrosis
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Sánchez-Torralvo, Francisco José, primary, Porras, Nuria, additional, Ruiz-García, Ignacio, additional, Maldonado-Araque, Cristina, additional, García-Olivares, María, additional, Girón, María Victoria, additional, Gonzalo-Marín, Montserrat, additional, Olveira, Casilda, additional, and Olveira, Gabriel, additional
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- 2022
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8. Prevalence of Obesity, Diabetes and Other Cardiovascular Risk Factors in Andalusia (Southern Spain). Comparison With National Prevalence Data. The Di@bet.es Study
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Valdés, Sergio, García-Torres, Francisca, Maldonado-Araque, Cristina, Goday, Albert, Calle-Pascual, Alfonso, Soriguer, Federico, Castaño, Luis, Catalá, Miguel, Gomis, Ramon, and Rojo-Martínez, Gemma
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- 2014
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9. Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study)
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Pediatría, Pediatria, Valdés, Sergio, Doulatram Gamgaram, Viyey, Maldonado Araque, Cristina, Lago Sampedro, Ana, García Escobar, Eva, García Serrano, Sara, García Vivanco, Marta, Garrido, Juan Luis, Theobald, Mark Richard, Gil, Victoria, Martín Llorente, Fernando, Ocón, Pilar, Calle Pascual, Alfonso, Castaño González, Luis Antonio, Delgado, Elías, Menéndez Torre, Edelmiro, Franch Nadal, Josep, Gaztambide Sáenz, María Sonia, Girbes, Joan, Chaves, Felipe J., Galán García, José Luis, Aguilera Venegas, Gabriel, Gutiérrez Repiso, Carolina, Fernández García, José Carlos, Colomo, Natalia, Soriguer, Federico, García Fuentes, Eduardo, Rojo Martínez, Gemma, Pediatría, Pediatria, Valdés, Sergio, Doulatram Gamgaram, Viyey, Maldonado Araque, Cristina, Lago Sampedro, Ana, García Escobar, Eva, García Serrano, Sara, García Vivanco, Marta, Garrido, Juan Luis, Theobald, Mark Richard, Gil, Victoria, Martín Llorente, Fernando, Ocón, Pilar, Calle Pascual, Alfonso, Castaño González, Luis Antonio, Delgado, Elías, Menéndez Torre, Edelmiro, Franch Nadal, Josep, Gaztambide Sáenz, María Sonia, Girbes, Joan, Chaves, Felipe J., Galán García, José Luis, Aguilera Venegas, Gabriel, Gutiérrez Repiso, Carolina, Fernández García, José Carlos, Colomo, Natalia, Soriguer, Federico, García Fuentes, Eduardo, and Rojo Martínez, Gemma
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Background Recent reports have suggested that air pollution may impact thyroid function, although the evidence is still scarce and inconclusive. In this study we evaluated the association of exposure to air pollutants to thyroid function parameters in a nationwide sample representative of the adult population of Spain. Methods The Di@bet.es study is a national, cross-sectional, population-based survey which was conducted in 2008-2010 using a random cluster sampling of the Spanish population. The present analyses included 3859 individuals, without a previous thyroid disease diagnosis, and with negative thyroid peroxidase antibodies (TPO Abs) and thyroid-stimulating hormone (TSH) levels of 0.1-20 mIU/L. Participants were assigned air pollution concentrations for particulate matter <2.5 mu m (PM2.5) and Nitrogen Dioxide (NO2), corresponding to the health examination year, obtained by means of modeling combined with measurements taken at air quality stations (CHIMERE chemistry-transport model). TSH, free thyroxine (FT4), free triiodothyronine (FT3) and TPO Abs concentrations were analyzed using an electrochemiluminescence immunoassay (Modular Analytics E170 Roche). Results In multivariate linear regression models, there was a highly significant negative correlation between PM2.5 concentrations and both FT4 (p<0.001), and FT3 levels (p<0.001). In multivariate logistic regression, there was a significant association between PM2.5 concentrations and the odds of presenting high TSH [OR 1.24 (1.01-1.52) p=0.043], lower FT4 [OR 1.25 (1.02-1.54) p=0.032] and low FT3 levels [1.48 (1.19-1.84) p=<0.001] per each IQR increase in PM2.5 (4.86 mu g/m(3)). There was no association between NO2 concentrations and thyroid hormone levels. No significant heterogeneity was seen in the results between groups of men, pre-menopausal and post-menopausal women. Conclusions Exposures to PM2.5 in the general population were associated with mild alterations in thyroid function.
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- 2022
10. Serum vascular endothelial growth factor b and metabolic syndrome incidence in the population based cohort Di@bet.es study
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Pediatría, Pediatria, Lago Sampedro, Ana, Lhamyani, Said, gonza, Valdés, Sergio, Colomo, Natalia, Maldonado Araque, Cristina, González Molero, Inmaculada, Doulatram Gamgaram, Viyey, Delgado, Elías, Chaves, Felipe J., Castaño González, Luis Antonio, Calle Pascual, Alfonso, Franch Nadal, Josep, Rojo Martínez, Gemma, García Serrano, Sara, García Escobar, Eva, Pediatría, Pediatria, Lago Sampedro, Ana, Lhamyani, Said, gonza, Valdés, Sergio, Colomo, Natalia, Maldonado Araque, Cristina, González Molero, Inmaculada, Doulatram Gamgaram, Viyey, Delgado, Elías, Chaves, Felipe J., Castaño González, Luis Antonio, Calle Pascual, Alfonso, Franch Nadal, Josep, Rojo Martínez, Gemma, García Serrano, Sara, and García Escobar, Eva
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Background/Objectives Although vascular endothelial growth factor b (VEGFb) might have an impact on the development of obesity, diabetes and related disorders, the possible relationship between VEGFb serum levels and the incidence of these metabolic complications in humans is still unknown. The aim of our study was to evaluate the association between VEGFb serum levels and the new-onset of metabolic syndrome (MS) and its components in the Spanish adult population after 7.5 years of follow-up. Subjects/Methods A total of 908 subjects from the Di@bet.es cohort study without MS at cross-sectional stage according to International Diabetes Federation (IDF) or Adult Treatment Panel III (ATP-III) criteria were included. Additionally, five sub-populations were grouped according to the absence of each MS component at baseline. Socio-demographic, anthropometric and clinical data were recorded. The Short Form of International Physical Activity Questionnaire (SF-IPAQ) was used to estimate physical activity. A fasting blood extraction and an oral glucose tolerance test were performed. Serum determinations of glucose, lipids, hsCRP and insulin were made. VEGFb levels were determined and categorized according to the 75th percentile of the variable. New cases of MS and its components were defined according to ATPIII and IDF criteria. Results A total of 181 or 146 people developed MS defined by IDF or ATP-III criteria respectively. Serum triglyceride levels, hs-CRP and systolic blood pressure at the baseline study were significantly different according to the VEGFb categories. Adjusted logistic regression analysis showed that the likelihood of developing MS and abdominal obesity was statistically reduced in subjects included in the higher VEGFb category. Conclusion Low serum levels of VEGFb may be considered as early indicators of incident MS and abdominal obesity in the Spanish adult population free of MS, independently of other important predictor variables.
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- 2022
11. Thyroid hormone resistance index and mortality in euthyroid subjects: Di@bet.es study
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Alonso, Silvia Patricia, primary, Valdés, Sergio, additional, Maldonado-Araque, Cristina, additional, Lago, Ana, additional, Ocon, Pilar, additional, Calle, Alfonso, additional, Castaño, Luis, additional, Delgado, Elías, additional, Menéndez, Edelmiro, additional, Franch-Nadal, Josep, additional, Gaztambide, Sonia, additional, Girbés, Juan, additional, Chaves, Felipe, additional, Garcia-Serrano, Sara, additional, Garcia-Escobar, Eva, additional, Fernandez-García, José Carlos, additional, Olveira, Gabriel, additional, Colomo, Natalia, additional, and Rojo-Martínez, Gemma, additional
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- 2022
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12. Association between long term exposure to particulate matter and incident hypertension in Spain
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Pediatría, Pediatria, Doulatram Gamgaram, Viyey, Valdés, Sergio, Maldonado Araque, Cristina, Lago Sampedro, Ana, Badía Guillén, Rocío, García Escobar, Eva, García Serrano, Sara, García Vivanco, Marta, Garrido, Juan Luis, Theobald, Mark Richard, Gil, Victoria, Martín Llorente, Fernando, Calle Pascual, Alfonso, Bordiú, Elena, Castaño González, Luis Antonio, Delgado, Elías, Franch Nadal, Josep, Chaves, Francisco Javier, Montanya, Eduard, Galán García, José Luis, Aguilera Venegas, Gabriel, Soriguer, Federico, Rojo Martínez, Gemma, Pediatría, Pediatria, Doulatram Gamgaram, Viyey, Valdés, Sergio, Maldonado Araque, Cristina, Lago Sampedro, Ana, Badía Guillén, Rocío, García Escobar, Eva, García Serrano, Sara, García Vivanco, Marta, Garrido, Juan Luis, Theobald, Mark Richard, Gil, Victoria, Martín Llorente, Fernando, Calle Pascual, Alfonso, Bordiú, Elena, Castaño González, Luis Antonio, Delgado, Elías, Franch Nadal, Josep, Chaves, Francisco Javier, Montanya, Eduard, Galán García, José Luis, Aguilera Venegas, Gabriel, Soriguer, Federico, and Rojo Martínez, Gemma
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[EN]Exposure to air particulate matter has been linked with hypertension and blood pressure levels. The metabolic risks of air pollution could vary according to the specific characteristics of each area, and has not been sufficiently evaluated in Spain. We analyzed 1103 individuals, participants in a Spanish nationwide population based cohort study (di@bet.es), who were free of hypertension at baseline (2008-2010) and completed a follow-up exam of the cohort (2016-2017). Cohort participants were assigned air pollution concentrations for particulate matter < 10 mu m (PM10) and < 2.5 mu m (PM2.5) during follow-up (2008-2016) obtained through modeling combined with measurements taken at air quality stations (CHIMERE chemistry-transport model). Mean and SD concentrations of PM10 and PM2.5 were 20.17 +/- 3.91 mu g/m(3) and 10.83 +/- 2.08 mu g/m(3) respectively. During follow-up 282 cases of incident hypertension were recorded. In the fully adjusted model, compared with the lowest quartile of PM10, the multivariate weighted ORs (95% CIs) for developing hypertension with increasing PM10 exposures were 0.82 (0.59-1.14), 1.28 (0.93-1.78) and 1.45 (1.05-2.01) in quartile 2, 3 and 4 respectively (p for a trend of 0.003). The corresponding weighted ORs according to PM2.5 exposures were 0.80 (0.57-1.13), 1.11 (0.80-1.53) and 1.48 (1.09-2.00) (p for trend 0.004). For each 5-mu g/m(3) increment in PM10 and PM2.5 concentrations, the odds for incident hypertension increased 1.22 (1.06-1.41) p = 0.007 and 1.39 (1.07-1.81) p = 0.02 respectively. In conclusion, our study contributes to assessing the impact of particulate pollution on the incidence of hypertension in Spain, reinforcing the need for improving air quality as much as possible in order to decrease the risk of cardiometabolic disease in the population.
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- 2021
13. Iodine Deficiency and Mortality in Spanish Adults: Di@bet.es Study
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Medicina, Pediatría, Medikuntza, Pediatria, Maldonado Araque, Cristina, Valdés, Sergio, Badía Guillén, Rocío, Lago Sampedro, Ana, Colomo, Natalia, García Fuentes, Eduardo, Gutiérrez Repiso, Carolina, Goday, Albert, Calle Pascual, Alfonso, Castaño González, Luis Antonio, Castell, Conxa, Delgado, Elías, Menéndez Torre, Edelmiro, Franch Nadal, Josep, Gaztambide Sáenz, María Sonia, Girbes, Joan, Chaves, Francisco Javier, Soriguer, Federico, Rojo Martínez, Gemma, Medicina, Pediatría, Medikuntza, Pediatria, Maldonado Araque, Cristina, Valdés, Sergio, Badía Guillén, Rocío, Lago Sampedro, Ana, Colomo, Natalia, García Fuentes, Eduardo, Gutiérrez Repiso, Carolina, Goday, Albert, Calle Pascual, Alfonso, Castaño González, Luis Antonio, Castell, Conxa, Delgado, Elías, Menéndez Torre, Edelmiro, Franch Nadal, Josep, Gaztambide Sáenz, María Sonia, Girbes, Joan, Chaves, Francisco Javier, Soriguer, Federico, and Rojo Martínez, Gemma
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Background:Longitudinal data assessing the impact of iodine deficiency (ID) on mortality are scarce. We aimed to study the association between the state of iodine nutrition and the risk of total and cause-specific mortality in a representative sample of the Spanish adult population. Methods:We performed a longitudinal observational study to estimate mortality risk according to urinary iodine (UI) concentrations using a sample of 4370 subjects >18 years representative of the Spanish adult population participating in the nationwide study Di@bet.es (2008-2010). We used Cox regression to assess the association between UI at the start of the study (<50, 50-99, 100-199, 200-299, and >= 300 mu g/L) and mortality during follow-up (National death registry-end of follow-up December 2016) in raw models, and adjusted for possible confounding variables: age, sex, educational level, hypertension, diabetes, obesity, chronic kidney disease, smoking, hypercholesterolemia, thyroid dysfunction, diagnosis of cardiovascular disease or cancer, area of residence, physical activity, adherence to Mediterranean diet, dairy and iodinated salt intake. Results:A total of 254 deaths were recorded during an average follow-up period of 7.3 years. The causes of death were cardiovascular 71 (28%); cancer 85 (33.5%); and other causes 98 (38.5%). Compared with the reference category with adequate iodine nutrition (UI 100-300 mu g/L), the hazard ratios (HRs) of all-cause mortality in the category with UI >= 300 mu g/L were 1.04 (95% confidence interval [CI 0.54-1.98]); however, in the categories with 50-99 UI and <50 mu g/L, the HRs were 1.29 [CI 0.97-1.70] and 1.71 [1.18-2.48], respectively (pfor trend 0.004). Multivariate adjustment did not significantly modify the results. Conclusions:Our data indicate an excess mortality in individuals with moderate-severe ID adjusted for other possible confounding factors.
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- 2021
14. Iodine Deficiency and Mortality in Spanish Adults: Di@bet.es Study
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Maldonado-Araque, Cristina, primary, Valdés, Sergio, additional, Badía-Guillén, Rocío, additional, Lago-Sampedro, Ana, additional, Colomo, Natalia, additional, Garcia-Fuentes, Eduardo, additional, Gutierrez-Repiso, Carolina, additional, Goday, Albert, additional, Calle-Pascual, Alfonso, additional, Castaño, Luis, additional, Castell, Conxa, additional, Delgado, Elías, additional, Menendez, Edelmiro, additional, Franch-Nadal, Josep, additional, Gaztambide, Sonia, additional, Girbés, Joan, additional, Chaves, Francisco Javier, additional, Soriguer, Federico, additional, and Rojo-Martínez, Gemma, additional
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- 2021
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15. Air pollution and incidence of hypertension in spanish adults Di@bet.es study
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Valdes, Sergio, primary, Doulatram-Gamgaram, Viyey, additional, Maldonado-Araque, Cristina, additional, Lago-Sampedro, Ana, additional, Martín-Llorente, Fernando, additional, García-Vivanco, Marta, additional, Calle-Pascual, Alfonso, additional, Castaño, Luis, additional, Delgado, Elias, additional, Franch-Nadal, Josep, additional, Montanya, Eduard, additional, and Rojo-Martinez, Gemma, additional
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- 2020
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16. Prevalencia de disfunción tiroidea en la población española. Implicación del hierro en la fisiología tiroidea
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Maldonado Araque, Cristina, Valdéz Hernández, Sergio, Soriguer Escofet, Federico, and Farmacología y Pediatría
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Tiroides - Enfermedades - Tesis doctorales ,Hipotiroidismo ,Epidemiología ,Ferropenia ,Hipotiroxinemia - Abstract
INTRODUCCIÓN La disfunción tiroidea es una patología frecuente en la población general. En España se dispone de pocos datos, de regiones pequeñas y de áreas con distinto estado nutricional de yodo, por lo que es necesario un estudio poblacional amplio y representativo de todo el país. La deficiencia de hierro es una de las más graves e importantes deficiencias nutricionales en el mundo. Estudios recientes relacionan la ferropenia con un metabolismo alterado de las hormonas tiroideas. Basándonos en la evidencia previa, nuestro objetivo es estudiar la asociación entre ferropenia y la disfunción tiroidea en una población libre de enfermedad tiroidea, representativa de la población general adulta en España. MATERIAL Y MÉTODOS El estudio Di@bet.es es una encuesta poblacional nacional, transversal, realizada entre los años 2008-2010. Se realizó un muestreo por conglomerados. De los más de 10.000 adultos elegibles, un 55,8% asistió a examen, 9,9% fueron excluidos (institucionalizados, enfermedad grave, gestación o parto reciente), dando una muestra final de 5061 individuos entre 18 y 93 años (41.6% hombres, 58,4% mujeres). El estudio fue aprobado por varios comités de ética y se obtuvo consentimiento informado de todos los participantes. Para el análisis de la ferropenia la muestra se centró en 3922 individuos (54,3% mujeres 45,7% hombres), libres de enfermedad tiroidea y con niveles de Anti-TPO < 50 IU/ml. Los participantes fueron evaluados en una única visita. Se obtuvo información de variables sociodemográficas y clínicas, así como exploración física y obtención de muestras biológicas de sangre y orina. Las muestras fueron gestionadas por el Biobanco del Hospital Regional Universitario de Málaga-IBIMA. Análisis estadístico Se calculó la prevalencia y el intervalo de confianza al 95% (IC 95%) de los diferentes subtipos de disfunción tiroidea en la muestra general y por sexo. Los datos se ajustaron a la estructura de la población española por edad y sexo. Para evaluar la asociación entre la disfunción tiroidea y otros factores, así como la relación entre ferropenia e hipotiroxinemia/hipotriyodotironinemia, usamos un modelo de regresión logística multivariante. Los valores aportados de p están basados en test de dos colas con significación estadística de 0,05. RESULTADOS La prevalencia de disfunción tiroidea sumando tanto hiper como hipotiroidismo fue de 9,9%, frente al 90,1% que no padecía ningún tipo de disfunción. Separando por tipos de patología tiroidea, el hipotiroidismo total supone el 9,1% (IC95% 8,2-10). El hipotiroidismo tratado representa el 4,2% (IC 95%: 3,6-4,9) de la población. El hipotiroidismo subclínico no tratado representa el 4,6% (IC 95%: 4.0-5,2) El hipotiroidismo clínico no tratado representa el 0,3% (IC 95%: 0,1-0,5). El hipotiroidismo total supone el 9,1% de la población española. El hipertiroidismo total supone el 0,8% de población (IC 95%: 0,6-1,1). En mujeres la prevalencia total fue de 14,4% y de 5,3% en hombres. Se encontraron anticuerpos anti-TPO en el 7,5% (IC 95%: 6,7-8,3) de la población española. En mujeres la prevalencia de anti-TPO es de 10,8% y en hombres es de 4,1%. La prevalencia de hipotiroxinemia aislada tomando como valor de referencia el p2,5 de la población es de 1,6% (IC95%: 1,0-2,2) en hombres y 2,4% (IC95%: 1,8-3,0) en mujeres. La prevalencia total es de 2,0% (IC95% 1,6-2,4). Tomando como valor de referencia el p5, es de 3,2% (IC95%: 2,4-4,0) en hombres y 4,9% (IC95%: 4,1-5,7) en mujeres. La prevalencia total es de 4,1% (IC95% 3,5-4,7). Las mujeres fueron 2.5 veces más propensas a tener hipotiroidismo de cualquier clase, que los hombres (p < 0.001), mientras que no hubo una asociación significativa de disfunción tiroidea con la edad. Los anti-TPO se asociaron se manera significativa con hipotiroidismo e hipertiroidismo. También había una asociación positiva entre la yoduria y la disfunción tiroidea. Se halló una asociación entre el hipotiroidismo y la zona de residencia (mayor probabilidad de hipotiroidismo en el centro de España comparado con la costa). Según las concentraciones de ferritina el 13,6% de la población tenía niveles de ferritina < 15 μg/L y el 14.7% tenía niveles de ferritina entre 15-29 μg/L. En el modelo de regresión logística multivariante, los sujetos con déficit de hierro (ferritina
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- 2017
17. Iron deficiency is associated with Hypothyroxinemia and Hypotriiodothyroninemia in the Spanish general adult population: Di@bet.es study
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Maldonado-Araque, Cristina, primary, Valdés, Sergio, additional, Lago-Sampedro, Ana, additional, Lillo-Muñoz, Juan Antonio, additional, Garcia-Fuentes, Eduardo, additional, Perez-Valero, Vidal, additional, Gutierrez-Repiso, Carolina, additional, Goday, Albert, additional, Urrutia, Ines, additional, Peláez, Laura, additional, Calle-Pascual, Alfonso, additional, Castaño, Luis, additional, Castell, Contxa, additional, Delgado, Elias, additional, Menendez, Edelmiro, additional, Franch-Nadal, Josep, additional, Gaztambide, Sonia, additional, Girbés, Joan, additional, Ortega, Emilio, additional, Vendrell, Joan, additional, Chacón, Matilde R., additional, Chaves, Felipe J., additional, Soriguer, Federico, additional, and Rojo-Martínez, Gemma, additional
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- 2018
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18. Reference values for TSH may be inadequate to define hypothyroidism in persons with morbid obesity: Di@bet.es study
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Valdés, Sergio, primary, Maldonado-Araque, Cristina, additional, Lago-Sampedro, Ana, additional, Lillo-Muñoz, Juan Antonio, additional, Garcia-Fuentes, Eduardo, additional, Perez-Valero, Vidal, additional, Gutiérrez-Repiso, Carolina, additional, Garcia-Escobar, Eva, additional, Goday, Albert, additional, Urrutia, Inés, additional, Peláez, Laura, additional, Calle-Pascual, Alfonso, additional, Bordiú, Elena, additional, Castaño, Luis, additional, Castell, Conxa, additional, Delgado, Elias, additional, Menéndez, Edelmiro, additional, Franch-Nadal, Josep, additional, Gaztambide, Sonia, additional, Girbés, Joan, additional, Ortega, Emilio, additional, Vendrell, Joan, additional, Chacón, Matilde R., additional, Javier Chaves, F., additional, Soriguer, Federico, additional, and Rojo-Martínez, Gemma, additional
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- 2017
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19. Population-Based National Prevalence of Thyroid Dysfunction in Spain and Associated Factors: Di@bet.es Study
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Valdés, Sergio, primary, Maldonado-Araque, Cristina, additional, Lago-Sampedro, Ana, additional, Lillo, J. Antonio, additional, Garcia-Fuentes, Eduardo, additional, Perez-Valero, Vidal, additional, Gutierrez-Repiso, Carolina, additional, Ocon-Sanchez, Pilar, additional, Goday, Albert, additional, Urrutia, Ines, additional, Peláez, Laura, additional, Calle-Pascual, Alfonso, additional, Bordiú, Elena, additional, Castaño, Luis, additional, Castell, Conxa, additional, Delgado, Elias, additional, Menendez, Edelmiro, additional, Franch, Josep, additional, Gaztambide, Sonia, additional, Girbés, Joan, additional, Ortega, Emilio, additional, Lopez-Alba, Alfonso, additional, Chaves, Felipe J., additional, Vendrell, Joan, additional, Chacón, Matilde R., additional, Soriguer, Federico, additional, and Rojo-Martínez, Gemma, additional
- Published
- 2017
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20. Randomized clinical trial of the efficacy and safety of insulin glargine vs. NPH insulin as basal insulin for the treatment of glucocorticoid induced hyperglycemia using continuous glucose monitoring in hospitalized patients with type 2 diabetes and respiratory disease
- Author
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Ruiz de Adana, María S., primary, Colomo, Natalia, additional, Maldonado-Araque, Cristina, additional, Fontalba, María I., additional, Linares, Francisca, additional, García-Torres, Francisca, additional, Fernández, Rosario, additional, Bautista, Carmen, additional, Olveira, Gabriel, additional, de la Cruz, José L., additional, Rojo-Martínez, Gemma, additional, and Valdés, Sergio, additional
- Published
- 2015
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21. Prevalence of thyroid dysfunction in Spain: diabetes study
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Valdes, Sergio, primary, Maldonado-Araque, Cristina, additional, Tapia, Maria Jose, additional, Lago, Ana, additional, Perez-Valero, Vidal, additional, Goday, Albert, additional, Castano, Luis, additional, Delgado, Edelmiro, additional, Vendrell, Joan, additional, Rojo-Martinez, Gemma, additional, and Soriguer, Federico, additional
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- 2015
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22. Population-Based National Prevalence of Thyroid Dysfunction in Spain and Associated Factors: Study.
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Valdés, Sergio, Maldonado-Araque, Cristina, Lago-Sampedro, Ana, Lillo, J. Antonio, Garcia-Fuentes, Eduardo, Perez-Valero, Vidal, Gutierrez-Repiso, Carolina, Ocon-Sanchez, Pilar, Goday, Albert, Urrutia, Ines, Peláez, Laura, Calle-Pascual, Alfonso, Bordiú, Elena, Castaño, Luis, Castell, Conxa, Delgado, Elias, Menendez, Edelmiro, Franch, Josep, Gaztambide, Sonia, and Girbés, Joan
- Subjects
- *
THYROID diseases , *DISEASE prevalence , *TRIIODOTHYRONINE , *HYPOTHYROIDISM , *PUBLIC health - Abstract
Background: The aim of this study was to investigate the national prevalence of thyroid dysfunction in Spain and its association with various clinical, environmental, and demographic variables. Methods: The study included 4554 subjects (42.4% men) with a mean age of 50 years (range 18-93 years), who were participants in a national, cross-sectional, population-based survey conducted in 2009-2010. Data gathered included clinical and demographic characteristics, physical examination, and blood sampling. Thyrotropin, free thyroxine, free triiodothyronine, and thyroid peroxidase antibody (TPOAb) concentrations were analyzed by electrochemiluminescence. Urinary iodine (UI) levels were measured in an isolated urine sample. Results: The prevalence of treated hypothyroidism, untreated subclinical hypothyroidism, and untreated clinical hypothyroidism was 4.2% [confidence interval (CI) 3.6-4.9%], 4.6% [CI 4.0-5.2%], and 0.3% [CI 0.1-0.5%], respectively. The prevalence of total hypothyroidism (including all fractions) was 9.1% [CI 8.2-10.0%]. The prevalence of total hyperthyroidism was 0.8% [CI 0.6-1.1]. A total of 7.5% [CI 6.7-8.3%] of the population tested positive for TPOAbs (≥50 IU/mL). In multivariate logistic regression models, TPOAbs were strongly associated with both hypothyroidism ( p < 0.001) and hyperthyroidism ( p = 0.005), whereas high UI levels (>200 μg/g creatinine) were associated with hypothyroidism ( p < 0.001). The positive association between UI and hypothyroidism remained for both treated ( p < 0.001) and untreated ( p < 0.05) hypothyroidism, whereas it was especially significant for non-autoimmune (TPOAbs negative) forms ( p < 0.001). At UI levels ≥200 μg/g, there was a positive correlation between UI and thyrotropin levels (β = 0.152, p < 0.001) and a negative correlation between UI and free triiodothyronine levels (β = −0.134, p = 0.001). Conclusion: According to the data, a large proportion (10%) of the Spanish population has some evidence of thyroid dysfunction. High TPOAb concentrations were associated with both hypo- and hyperthyroidism, whereas high UI concentrations were associated with hypothyroidism. [ABSTRACT FROM AUTHOR]
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- 2017
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23. Ambient temperature and prevalence of obesity in the Spanish population: The Di@bet.es study
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Valdés, Sergio, primary, Maldonado-Araque, Cristina, additional, García-Torres, Francisca, additional, Goday, Alberto, additional, Bosch-Comas, Ana, additional, Bordiú, Elena, additional, Calle-Pascual, Alfonso, additional, Carmena, Rafael, additional, Casamitjana, Roser, additional, Castaño, Luis, additional, Castell, Conxa, additional, Catalá, Miguel, additional, Delgado, Elias, additional, Franch, Josep, additional, Gaztambide, Sonia, additional, Girbés, Juan, additional, Gomis, Ramon, additional, Gutiérrez, Galder, additional, López-Alba, Alfonso, additional, Martínez-Larrad, Maria, additional, Menéndez, Edelmiro, additional, Mora-Peces, Inmaculada, additional, Ortega, Emilio, additional, Pascual-Manich, Gemma, additional, Serrano-Rios, Manuel, additional, Urrutia, Ines, additional, Vázquez, Jose Antonio, additional, Vendrell, Joan, additional, Soriguer, Federico, additional, and Rojo-Martínez, Gemma, additional
- Published
- 2014
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24. Prevalencia de obesidad, diabetes mellitus y otros factores de riesgo cardiovascular en Andalucía. Comparación con datos de prevalencia nacionales. Estudio Di@bet.es
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Valdés, Sergio, primary, García-Torres, Francisca, additional, Maldonado-Araque, Cristina, additional, Goday, Albert, additional, Calle-Pascual, Alfonso, additional, Soriguer, Federico, additional, Castaño, Luis, additional, Catalá, Miguel, additional, Gomis, Ramon, additional, and Rojo-Martínez, Gemma, additional
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- 2014
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25. Climate and risk of obesity: di@bet.es study
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Valdes, Sergio, primary, Maldonado-Araque, Cristina, additional, Garcia-Torres, Francisca, additional, Goday, Albert, additional, Calle-Pascual, Alfonso, additional, Castano, Luis, additional, Castell, Contxa, additional, Catala, Miguel, additional, Delgado, Elias, additional, Franch, Josep, additional, Gaztambide, Sonia, additional, Gomis, Ramon, additional, Menendez, Edelmiro, additional, Ortega, Emilio, additional, Vendrell, Joan, additional, Soriguer, Federico, additional, and Rojo-Martinez, Gemma, additional
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- 2014
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26. Thyroid hormone resistance index and mortality in euthyroid subjects: Di@bet.es study.
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Alonso SP, Valdés S, Maldonado-Araque C, Lago A, Ocon P, Calle A, Castaño L, Delgado E, Menéndez E, Franch-Nadal J, Gaztambide S, Girbés J, Chaves F, Garcia-Serrano S, Garcia-Escobar E, Fernandez-García JC, Olveira G, Colomo N, and Rojo-Martínez G
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Comorbidity, Female, Health Status Indicators, Humans, Independent Living statistics & numerical data, Longitudinal Studies, Male, Middle Aged, Patient Acuity, Risk Factors, Spain epidemiology, Thyroid Function Tests, Thyroid Hormone Resistance Syndrome pathology, Young Adult, Asymptomatic Diseases epidemiology, Thyroid Hormone Resistance Syndrome epidemiology, Thyroid Hormone Resistance Syndrome mortality
- Abstract
Objective: It has been proposed that a mild form of acquired resistance to thyroid hormone may occur in the general population. Its clinical significance remains largely unknown. The objective of the study was to explore whether a newly described thyroid hormone resistance index is associated with the risk of mortality in a sample of community-dwelling euthyroid subjects representative of the adult population of Spain., Design: Longitudinal observational study including 3750 individuals, free of thyroid disease, TPO antibodies-negative (<50 IU/mL) and with TSH levels within the euthyroid range (≥0.5 and ≤5.0 mUI/mL) participating in the nationwide study Di@bet.es (2008-2010)., Methods: We used the Thyroid Feedback Quantile-based Index (TFQI) as a marker of resistance to thyroid hormone. The study population was grouped into categories according to their TFQI values at baseline. Fatal events were ascertained from the national death registry (end of follow-up December 2016)., Results: A total of 231 deaths were recorded during an average follow-up of 7.3 years. Compared with the category with the highest sensitivity to free thyroxine (TFQI ≤ p5) (reference), the relative risk of mortality in the categories with TFQI > p5 and ≤p25; >p25 and ≤p50; >p50 and ≤p75; >p75 and ≤p95 and >p95 were 1.01, (0.47-2.19), 1.42 (0.68-2.97), 1.54 (0.74-3.22), 1.47 (0.70-3.11) and 2.61 (1.16-5.89), respectively (P for trend 0.003). The association remained significant after multivariate adjustment of the data (P for trend 0.017)., Conclusions: A thyroid hormone resistance index focused on deviations of the average pituitary response to thyroid hormones may be associated with all-cause mortality independently of other conventional risk factors and comorbidities.
- Published
- 2021
- Full Text
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