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3. Assessing physical activity in people with mental illness: 23-country reliability and validity of the simple physical activity questionnaire (SIMPAQ)

Author

Rosenbaum, S., Morell, R., Abdel-Baki, A., Ahmadpanah, M., Anilkumar, T. V., Baie, L., Bauman, A., Bender, S., Boyan Han, J., Brand, S., Bratland-Sanda, S., Bueno-Antequera, J., Camaz Deslandes, A., Carneiro, L., Carraro, A., Castañeda, C. P., Castro Monteiro, F., Chapman, J., Chau, J. Y., Chen, L. J., Chvatalova, B., Chwastiak, L., Corretti, G., Dillon, M., Douglas, C., Egger, S. T., Gaughran, F., Gerber, M., Gobbi, E., Gould, K., Hatzinger, M., Holsboer-Trachsler, E., Hoodbhoy, Z., Imboden, C., Indu, P. S., Iqbal, R., Jesus-Moraleida, F. R., Kondo, S., Ku, P. W., Lederman, O., Lee, E. H. M., Malchow, B., Matthews, E., Mazur, P., Meneghelli, A., Mian, A., Morseth, B., Munguia-Izquierdo, D., Nyboe, L., O’Donoghue, B., Perram, A., Richards, J., Romain, A. J., Romaniuk, M., Sadeghi Bahmani, D., Sarno, M., Schuch, F., Schweinfurth, N., Stubbs, B., Uwakwe, R., Van Damme, T., Van Der Stouwe, E., Vancampfort, D., Vetter, S., Waterreus, A., and Ward, P. B.

Published
2020
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4. Structural brain changes are associated with response of negative symptoms to prefrontal repetitive transcranial magnetic stimulation in patients with schizophrenia

Author

Hasan, A, Wobrock, T, Guse, B, Langguth, B, Landgrebe, M, Eichhammer, P, Frank, E, Cordes, J, Wölwer, W, Musso, F, Winterer, G, Gaebel, W, Hajak, G, Ohmann, C, Verde, P E, Rietschel, M, Ahmed, R, Honer, W G, Dechent, P, Malchow, B, Castro, M F U, Dwyer, D, Cabral, C, Kreuzer, P M, Poeppl, T B, Schneider-Axmann, T, Falkai, P, and Koutsouleris, N

Published
2017
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7. Genetic variants associated with longitudinal changes in brain structure across the lifespan

Author

Brouwer, RM, Klein, M, Grasby, KL, Schnack, HG, Jahanshad, N, Teeuw, J, Thomopoulos, SI, Sprooten, E, Franz, CE, Gogtay, N, Kremen, WS, Panizzon, MS, Olde Loohuis, LM, Whelan, CD, Aghajani, M, Alloza, C, Alanaes, D, Artiges, E, Ayesa-Arriola, R, Barker, GJ, Bastin, ME, Blok, E, Boen, E, Breukelaar, IA, Bright, JK, Buimer, EEL, Bulow, R, Cannon, DM, Ciufolini, S, Crossley, NA, Damatac, CG, Dazzan, P, de Mol, CL, de Zwarte, SMC, Desrivieres, S, Diaz-Caneja, CM, Doan, NT, Dohm, K, Froehner, JH, Goltermann, J, Grigis, A, Grotegerd, D, Han, LKM, Harris, MA, Hartman, CA, Heany, SJ, Heindel, W, Heslenfeld, DJ, Hohmann, S, Ittermann, B, Jansen, PR, Janssen, J, Jia, T, Jiang, J, Jockwitz, C, Karali, T, Keeser, D, Koevoets, MGJC, Lenroot, RK, Malchow, B, Mandl, RCW, Medel, V, Meinert, S, Morgan, CA, Muehleisen, TW, Nabulsi, L, Opel, N, de la Foz, VO-G, Overs, BJ, Paillere Martinot, M-L, Redlich, R, Marques, TR, Repple, J, Roberts, G, Roshchupkin, GV, Setiaman, N, Shumskaya, E, Stein, F, Sudre, G, Takahashi, S, Thalamuthu, A, Tordesillas-Gutierrez, D, van der Lugt, A, van Haren, NEM, Wardlaw, JM, Wen, W, Westeneng, H-J, Wittfeld, K, Zhu, AH, Zugman, A, Armstrong, NJ, Bonfiglio, G, Bralten, J, Dalvie, S, Davies, G, Di Forti, M, Ding, L, Donohoe, G, Forstner, AJ, Gonzalez-Penas, J, Guimaraes, JPOFT, Homuth, G, Hottenga, J-J, Knol, MJ, Kwok, JBJ, Le Hellard, S, Mather, KA, Milaneschi, Y, Morris, DW, Noethen, MM, Papiol, S, Rietschel, M, Santoro, ML, Steen, VM, Stein, JL, Streit, F, Tankard, RM, Teumer, A, van 't Ent, D, van der Meer, D, van Eijk, KR, Vassos, E, Vazquez-Bourgon, J, Witt, SH, Adams, HHH, Agartz, I, Ames, D, Amunts, K, Andreassen, OA, Arango, C, Banaschewski, T, Baune, BT, Belangero, SI, Bokde, ALW, Boomsma, DI, Bressan, RA, Brodaty, H, Buitelaar, JK, Cahn, W, Caspers, S, Cichon, S, Crespo-Facorro, B, Cox, SR, Dannlowski, U, Elvsashagen, T, Espeseth, T, Falkai, PG, Fisher, SE, Flor, H, Fullerton, JM, Garavan, H, Gowland, PA, Grabe, HJ, Hahn, T, Heinz, A, Hillegers, M, Hoare, J, Hoekstra, PJ, Ikram, MA, Jackowski, AP, Jansen, A, Jonsson, EG, Kahn, RS, Kircher, T, Korgaonkar, MS, Krug, A, Lemaitre, H, Malt, UF, Martinot, J-L, McDonald, C, Mitchell, PB, Muetzel, RL, Murray, RM, Nees, F, Nenadic, I, Oosterlaan, J, Ophoff, RA, Pan, PM, Penninx, BWJH, Poustka, L, Sachdev, PS, Salum, GA, Schofield, PR, Schumann, G, Shaw, P, Sim, K, Smolka, MN, Stein, DJ, Trollor, JN, van den Berg, LH, Veldink, JH, Walter, H, Westlye, LT, Whelan, R, White, T, Wright, MJ, Medland, SE, Franke, B, Thompson, PM, Hulshoff Pol, HE, Brouwer, RM, Klein, M, Grasby, KL, Schnack, HG, Jahanshad, N, Teeuw, J, Thomopoulos, SI, Sprooten, E, Franz, CE, Gogtay, N, Kremen, WS, Panizzon, MS, Olde Loohuis, LM, Whelan, CD, Aghajani, M, Alloza, C, Alanaes, D, Artiges, E, Ayesa-Arriola, R, Barker, GJ, Bastin, ME, Blok, E, Boen, E, Breukelaar, IA, Bright, JK, Buimer, EEL, Bulow, R, Cannon, DM, Ciufolini, S, Crossley, NA, Damatac, CG, Dazzan, P, de Mol, CL, de Zwarte, SMC, Desrivieres, S, Diaz-Caneja, CM, Doan, NT, Dohm, K, Froehner, JH, Goltermann, J, Grigis, A, Grotegerd, D, Han, LKM, Harris, MA, Hartman, CA, Heany, SJ, Heindel, W, Heslenfeld, DJ, Hohmann, S, Ittermann, B, Jansen, PR, Janssen, J, Jia, T, Jiang, J, Jockwitz, C, Karali, T, Keeser, D, Koevoets, MGJC, Lenroot, RK, Malchow, B, Mandl, RCW, Medel, V, Meinert, S, Morgan, CA, Muehleisen, TW, Nabulsi, L, Opel, N, de la Foz, VO-G, Overs, BJ, Paillere Martinot, M-L, Redlich, R, Marques, TR, Repple, J, Roberts, G, Roshchupkin, GV, Setiaman, N, Shumskaya, E, Stein, F, Sudre, G, Takahashi, S, Thalamuthu, A, Tordesillas-Gutierrez, D, van der Lugt, A, van Haren, NEM, Wardlaw, JM, Wen, W, Westeneng, H-J, Wittfeld, K, Zhu, AH, Zugman, A, Armstrong, NJ, Bonfiglio, G, Bralten, J, Dalvie, S, Davies, G, Di Forti, M, Ding, L, Donohoe, G, Forstner, AJ, Gonzalez-Penas, J, Guimaraes, JPOFT, Homuth, G, Hottenga, J-J, Knol, MJ, Kwok, JBJ, Le Hellard, S, Mather, KA, Milaneschi, Y, Morris, DW, Noethen, MM, Papiol, S, Rietschel, M, Santoro, ML, Steen, VM, Stein, JL, Streit, F, Tankard, RM, Teumer, A, van 't Ent, D, van der Meer, D, van Eijk, KR, Vassos, E, Vazquez-Bourgon, J, Witt, SH, Adams, HHH, Agartz, I, Ames, D, Amunts, K, Andreassen, OA, Arango, C, Banaschewski, T, Baune, BT, Belangero, SI, Bokde, ALW, Boomsma, DI, Bressan, RA, Brodaty, H, Buitelaar, JK, Cahn, W, Caspers, S, Cichon, S, Crespo-Facorro, B, Cox, SR, Dannlowski, U, Elvsashagen, T, Espeseth, T, Falkai, PG, Fisher, SE, Flor, H, Fullerton, JM, Garavan, H, Gowland, PA, Grabe, HJ, Hahn, T, Heinz, A, Hillegers, M, Hoare, J, Hoekstra, PJ, Ikram, MA, Jackowski, AP, Jansen, A, Jonsson, EG, Kahn, RS, Kircher, T, Korgaonkar, MS, Krug, A, Lemaitre, H, Malt, UF, Martinot, J-L, McDonald, C, Mitchell, PB, Muetzel, RL, Murray, RM, Nees, F, Nenadic, I, Oosterlaan, J, Ophoff, RA, Pan, PM, Penninx, BWJH, Poustka, L, Sachdev, PS, Salum, GA, Schofield, PR, Schumann, G, Shaw, P, Sim, K, Smolka, MN, Stein, DJ, Trollor, JN, van den Berg, LH, Veldink, JH, Walter, H, Westlye, LT, Whelan, R, White, T, Wright, MJ, Medland, SE, Franke, B, Thompson, PM, and Hulshoff Pol, HE

Abstract

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.

Published
2022

17. Effect of aerobic exercise on cortical thickness in patients with schizophrenia: A dataset

Author

Takahashi, S., Keeser, D., Rauchmann, B.S., Schneider-Axmann, T., Keller-Varady, K., Maurus, I., Dechent, P., Wobrock, T., Hasan, A., Schmitt, A., Ertl-Wagner, B., Malchow, B., Falkai, P., Takahashi, S., Keeser, D., Rauchmann, B.S., Schneider-Axmann, T., Keller-Varady, K., Maurus, I., Dechent, P., Wobrock, T., Hasan, A., Schmitt, A., Ertl-Wagner, B., Malchow, B., and Falkai, P.

Abstract

Contains fulltext : 220348.pdf (publisher's version ) (Open Access), This is a data article from the original publication "Effect of aerobic exercise combined with cognitive remediation on cortical thickness and prediction of social adaptation in patients with schizophrenia"[1]. Twenty-one patients with schizophrenia and 23 healthy controls underwent aerobic exercise. Another 21 patients with schizophrenia played table soccer instead. The 12-week exercise intervention was combined with computer-assisted cognitive remediation training from week 6 to week 12. Clinical assessments were conducted at baseline and after the 12-week intervention. Magnetic resonance imaging (MRI) scans were acquired at baseline then in weeks 6, 12, and 24. The thickness of the entorhinal, parahippocampal, and lateral and medial prefrontal cortices was assessed with FreeSurfer 6.0. Data are publicy available via https://osf.io/sfgxk/.

Published
2020

18. Effect of aerobic exercise combined with cognitive remediation on cortical thickness and prediction of social adaptation in patients with schizophrenia

Author

Takahashi, S., Keeser, D., Rauchmann, B.S., Schneider-Axmann, T., Keller-Varady, K., Maurus, I., Dechent, P., Wobrock, T., Hasan, A., Schmitt, A., Ertl-Wagner, B., Malchow, B., Falkai, P., Takahashi, S., Keeser, D., Rauchmann, B.S., Schneider-Axmann, T., Keller-Varady, K., Maurus, I., Dechent, P., Wobrock, T., Hasan, A., Schmitt, A., Ertl-Wagner, B., Malchow, B., and Falkai, P.

Abstract

Item does not contain fulltext, Aerobic exercise is a promising intervention for patients with schizophrenia, but structural neuroplastic effects on brain regions relevant to the pathophysiology of the disease remain unclear. This study aimed to elucidate longitudinal changes in cortical thickness after aerobic exercise intervention in schizophrenia patients and the relationship of these changes to clinical correlates. We investigated 21 schizophrenia patients and 23 healthy controls who performed aerobic exercise and 21 schizophrenia patients who played table soccer. The 12-week exercise intervention was combined with computer-assisted cognitive remediation training from week 6 to week 12. Magnetic resonance imaging (MRI) scans were acquired at baseline and weeks 6,12, and 24. The thickness of the entorhinal, parahippocampal, and lateral and medial prefrontal cortices was assessed with FreeSurfer 6.0. The schizophrenia aerobic exercise group showed a significant increase of cortical thickness in the right entorhinal cortex at week 6, and we found a significant correlation between the cortical thickness of the right lateral prefrontal cortex at baseline and improvement of social adaptation at week 12. In the schizophrenia table soccer and healthy control groups, we found no significant longitudinal change in cortical thickness through the intervention and follow-up period and no correlation of cortical thickness at baseline with clinical measures. Our results suggest that aerobic exercise in schizophrenia modulates the thickness of the entorhinal cortex, a structure adjacent to the hippocampus. Greater cortical thickness of the right lateral prefrontal cortex appears to predict better clinical response to an aerobic exercise intervention in patients with schizophrenia.

Published
2020

19. Assessing physical activity in people with mental illness: 23-country reliability and validity of the simple physical activity questionnaire (SIMPAQ)

Author

Rosenbaum, S, Morell, R, Abdel-Baki, A, Ahmadpanah, M, Anilkumar, T, Baie, L, Bauman, A, Bender, S, Han, JB, Brand, S, Bratland-Sanda, S, Bueno-Antequera, J, Camaz Deslandes, A, Carneiro, L, Carraro, A, Castaneda, CP, Castro Monteiro, F, Chapman, J, Chau, JY, Chen, LJ, Chvatalova, B, Chwastiak, L, Corretti, G, Dillon, M, Douglas, C, Egger, ST, Gaughran, F, Gerber, M, Gobbi, E, Gould, K, Hatzinger, M, Holsboer-Trachsler, E, Hoodbhoy, Z, Imboden, C, Indu, PS, Iqbal, R, Jesus-Moraleida, FR, Kondo, S, Ku, PW, Lederman, O, Lee, EHM, Malchow, B, Matthews, E, Mazur, P, Meneghelli, A, Mian, A, Morseth, B, Munguia-Izquierdo, D, Nyboe, L, O'Donoghue, B, Perram, A, Richards, J, Romain, AJ, Romaniuk, M, Bahmani, DS, Sarno, M, Schuch, F, Schweinfurth, N, Stubbs, B, Uwakwe, R, Van Damme, T, Van der Stouwe, E, Vancampfort, D, Vetter, S, Waterreus, A, Ward, PB, Rosenbaum, S, Morell, R, Abdel-Baki, A, Ahmadpanah, M, Anilkumar, T, Baie, L, Bauman, A, Bender, S, Han, JB, Brand, S, Bratland-Sanda, S, Bueno-Antequera, J, Camaz Deslandes, A, Carneiro, L, Carraro, A, Castaneda, CP, Castro Monteiro, F, Chapman, J, Chau, JY, Chen, LJ, Chvatalova, B, Chwastiak, L, Corretti, G, Dillon, M, Douglas, C, Egger, ST, Gaughran, F, Gerber, M, Gobbi, E, Gould, K, Hatzinger, M, Holsboer-Trachsler, E, Hoodbhoy, Z, Imboden, C, Indu, PS, Iqbal, R, Jesus-Moraleida, FR, Kondo, S, Ku, PW, Lederman, O, Lee, EHM, Malchow, B, Matthews, E, Mazur, P, Meneghelli, A, Mian, A, Morseth, B, Munguia-Izquierdo, D, Nyboe, L, O'Donoghue, B, Perram, A, Richards, J, Romain, AJ, Romaniuk, M, Bahmani, DS, Sarno, M, Schuch, F, Schweinfurth, N, Stubbs, B, Uwakwe, R, Van Damme, T, Van der Stouwe, E, Vancampfort, D, Vetter, S, Waterreus, A, and Ward, PB

Abstract

BACKGROUND: Physical inactivity is a key contributor to the global burden of disease and disproportionately impacts the wellbeing of people experiencing mental illness. Increases in physical activity are associated with improvements in symptoms of mental illness and reduction in cardiometabolic risk. Reliable and valid clinical tools that assess physical activity would improve evaluation of intervention studies that aim to increase physical activity and reduce sedentary behaviour in people living with mental illness. METHODS: The five-item Simple Physical Activity Questionnaire (SIMPAQ) was developed by a multidisciplinary, international working group as a clinical tool to assess physical activity and sedentary behaviour in people living with mental illness. Patients with a DSM or ICD mental illness diagnoses were recruited and completed the SIMPAQ on two occasions, one week apart. Participants wore an Actigraph accelerometer and completed brief cognitive and clinical assessments. RESULTS: Evidence of SIMPAQ validity was assessed against accelerometer-derived measures of physical activity. Data were obtained from 1010 participants. The SIMPAQ had good test-retest reliability. Correlations for moderate-vigorous physical activity was comparable to studies conducted in general population samples. Evidence of validity for the sedentary behaviour item was poor. An alternative method to calculate sedentary behaviour had stronger evidence of validity. This alternative method is recommended for use in future studies employing the SIMPAQ. CONCLUSIONS: The SIMPAQ is a brief measure of physical activity and sedentary behaviour that can be reliably and validly administered by health professionals.

Published
2020

26. Polygenic risk has an impact on the structural plasticity of hippocampal subfields during aerobic exercise combined with cognitive remediation in multi-episode schizophrenia

Author

Papiol, S, primary, Popovic, D, additional, Keeser, D, additional, Hasan, A, additional, Schneider-Axmann, T, additional, Degenhardt, F, additional, Rossner, M J, additional, Bickeböller, H, additional, Schmitt, A, additional, Falkai, P, additional, and Malchow, B, additional

Published
2017
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29. Sleeve-Gastrektomie vs. Magenbypass: Quality of life Analyse im 2-Jahresverlauf nach OP

Author

Ahrens, M, von Schoenfels, W, Laudes, M, Schafmayer, C, Becker, T, Malchow, B, and Küchler, T

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Sleevegasgastrektomie (SG) und der prox. Magenbypaa (pRYGB) sind die am häufigsten in Deutschland durchgeführten Operationen im Einsatz gegen das weltweit am schnellsten wachsende Gesundheitsrisiko Adipositas. Beide Verfahren sind hoch effektiv im Erreichenund Halten einer[for full text, please go to the a.m. URL], 131. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2014
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30. Structural brain changes are associated with response of negative symptoms to prefrontal repetitive transcranial magnetic stimulation in patients with schizophrenia

Author

Hasan, A, primary, Wobrock, T, additional, Guse, B, additional, Langguth, B, additional, Landgrebe, M, additional, Eichhammer, P, additional, Frank, E, additional, Cordes, J, additional, Wölwer, W, additional, Musso, F, additional, Winterer, G, additional, Gaebel, W, additional, Hajak, G, additional, Ohmann, C, additional, Verde, P E, additional, Rietschel, M, additional, Ahmed, R, additional, Honer, W G, additional, Dechent, P, additional, Malchow, B, additional, Castro, M F U, additional, Dwyer, D, additional, Cabral, C, additional, Kreuzer, P M, additional, Poeppl, T B, additional, Schneider-Axmann, T, additional, Falkai, P, additional, and Koutsouleris, N, additional

Published
2016
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33. Ist die Summe mehr als seine Einzelteile? – Eine Patientenbefragung im Traumazentrum

Author

Malchow, B

Subjects
ddc: 610, Traumazentrum, Patientenbefragung, 610 Medical sciences, Medicine, UKSH
Abstract

Hintergrund: Das UKSH hat 2011 im Rahmen seiner medizinischen Kompetenzzentren ein Traumazentrum etabliert. Ziel war und ist zur Versorgung von Schwer- und Mehrfachverletzten Rahmenbedingungen zu schaffen, um innerhalb kürzester Zeit ein hochkompetentes, interdisziplinäres Team zur Behandlung[for full text, please go to the a.m. URL], 12. Deutscher Kongress für Versorgungsforschung

Published
2013
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34. Humanität durch Technik: Etablierung einer webbasierten Beschwerdemanagement-Datenbank zur effizienten Bearbeitung von Beschwerden in der Chirurgie

Author

Malchow, B., Krauss, C., Gerhart, H., Holm-Doroszenko, R., Boll, P., Van Der Sloot, E., and Küchler, T.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Das UK S-H hat 2004 beschlossen, campusübergreifend ein Beschwer-demanagementsystem aufzubauen. Ziel ist es Beschwerden und Anregungen der Patienten zeitnah, zentral und systematisch zu erfassen, um 1. die Patientenzufriedenheit während des Aufenthalts zu erhöhen, 2. Verbesserungspotentiale[for full text, please go to the a.m. URL], 126. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2009

40. erste Ergebnisse

Author

Malchow, B, Jahnke, I, Küchler, T, and Kremer, B

Subjects
ddc: 610
Published
2005

47. Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia

Author

Kittel-Schneider, S., primary, Wobrock, T., additional, Scherk, H., additional, Schneider-Axmann, T., additional, Trost, S., additional, Zilles, D., additional, Wolf, C., additional, Schmitt, A., additional, Malchow, B., additional, Hasan, A., additional, Backens, M., additional, Reith, W., additional, Falkai, P., additional, Gruber, O., additional, and Reif, A., additional

Published
2014
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