Author: "Malavera, Alejandra" - Searchworks@Jio Institute Digital Library Search Results

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1. Baseline brain imaging signs in patients with ischaemic stroke by the presence of atrial fibrillation: the ENCHANTED trial

Author: Wang, Xia, You, Shoujiang, Zhou, Zien, Delcourt, Candice, Wardlaw, Joanna, Mair, Grant, Robinson, Thompson, Chen, Xiaoying, Yoshimura, Sohei, Torii-Yoshimura, Takako, Carcel, Cheryl, Malavera, Alejandra, Anderson, Craig, and Lindley, Richard I.
Published: 2023
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2. The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial

Author: Robinson, Thompson, Miranda, J. Jaime, Anderson, Craig S., You, Chao, Song, Lili, Parry-Jones, Adrian, Sprigg, Nikola, Durrans, Sophie, Harris, Caroline, Bamford, Ann, Smith, Olivia, Herbert, Robert, Chen, Christopher, Whiteley, William, Hu, Rong, Billot, Laurent, Li, Qiang, Mysore, Jayanthi, Hu, Xin, Zhang, Yao, Liu, Feifeng, Sakamoto, Yuki, You, Shoujiang, Han, Qiao, Crutzen, Bernard, Li, Yunke, Cheung, Emily, Jan, Stephen, Liu, Hueiming, Ouyang, Menglu, Sun, Lingli, Chu, Honglin, Anjum, Anila, Gonzalez Mc Cawley, Francisca, Del Rio, Alejandra, Rimoli, Bruna, Cerantola, Rodrigo, Jeevarajah, Thanushanthan, Kannangara, Madhushani, Joseph, Andrene, Nanayakkara, Chamath, Chen, Xiaoying, Malavera, Alejandra, Zhang, Chunmiao, Yang, Zhao, Li, Brook, Meng, Zhuo, Liu, Leibo, Ning, Yi, Dong, Le, Armenis, Manuela, Lim, Joyce, Monaghan, Helen, Ma, Lu, Li, Xi, Luo, Rui, Cheng, Guojuan, Dong, Yilin, Liu, Ziqin, Wang, Shuihong, Zhang, Ying, Cheng, Jipeng, Shi, Hui, Li, Wenjing, Mou, Langming, Yi, Ping, Chen, Chen, Chen, Xue, Weerawardena, Shalomi, Ellawala, Poornima, Ranasinghe, Enalee, Rodrigo, Chrishmi, Wahab, Kolawala, Adeniyi, Sunday, Pandian, Jeyaraj, Khanna, Megha, Muñoz Venturelli, Paula, González, Francisca, Urrutia Goldsack, Francisca, Wasay, Mohammad, Begum, Dilshad, Pontes-Neto, Octavio, Camilo, Millene, Dias, Francisco, Vincenzi, Octavio, Moro, Carla, Santos, Renata, Texeira, Nara, Longo, Alexandre, Liberato, Rafaela, Martins, Sheila, Pille, Arthur, Chwal, Bruna, Silva, Isabel, Titton, Natacha, Weiss, Gustavo, Mora, Daissy, Ouriques, Magda, Carbonera, Leonardo, Bazan, Rodrigo, Modolo, Gabriel, Winckler, Fernanda, Miranda, Luana, Souza, Juli, Rojo, Alexis, Uslar, Wilhelm, Medel, Lorena, Lopez, Javiera, Herrero, Diego, Lavados, Pablo, Vargas Latorre, Barbara, Conejan, Nathalie, Esparza, Tomas, Sotomayor, Patricio, Wenger, Denisse, Gigoux, Juan Pablo, Letelier, Aldo, Acevedo, Lilian, Moya, Vivianne, Figueroa, Cristian, Vallejos, Nicol, Guerrero, Rodrigo, Velasquez, Mauricio, Vallejos, Jose, Pallauta, Kimerly, Santibanez, Tamara, Queirolo, Angelo, Lobos, Andrea, Jiang, Yongming, Li, Weimin, Huang, Wei, Luo, Ke, Liu, Gangying, Tang, Guanghai, Yang, Guang, Jiang, Hongtao, Zhang, Xu, Jing, Hongyan, Zhu, Sheng, Pu, Bo, Lv, Dong, Kang, Hui, Hu, Qiuping, She, Xiaochun, Jiang, Xiaoming, Chen, Yanli, Yang, Shenghua, He, Jianjun, Li, Zongping, Cheng, Gang, Huang, Hailin, Wang, Xiaoyi, Lin, Jianqiong, Chen, Minhui, Yang, Chenghao, Ding, Hao, Deng, Yunliang, Luo, Fei, Zhang, Rongjun, Wang, Xiaofeng, Zhang, Hongbing, Yang, Xiaoliang, Zhang, Yang, Yang, Chengyi, He, Yu, Liu, Feng, Wang, Rongjie, Zhang, Yuhui, Xin, Xiaodong, Feng, Bin, Hao, Wanru, Song, Chang, Guo, Yun, Jiang, Dehua, Chen, Jie, Tang, Changtong, Zhu, Hongliang, Li, Xin, Cui, Jin, Xu, Haidong, Li, Boyang, Tang, Fusheng, Li, Yuanbin, Gao, Min, Yang, Bo, Xu, Xuejun, Deng, Bing, Zheng, Yi, Ge, Yuanhong, Chen, Keyu, Liu, Yang, Li, Xinshen, Zhong, Tingting, Xu, Jianfeng, Zhang, Hai, Wang, Jiyue, Zhu, Jianxin, Sun, Hanyu, Yu, Fuhua, Zhang, Xueguang, Xu, Jianguo, Zhang, Mingsen, Wang, Bin, Ma, Yiming, Jiang, Donglin, Zhou, Jun, Liu, Cong, Nie, Wenhong, Li, Mingguo, Tian, Tao, Li, Yong, He, Mingfang, Tu, Xiaolong, Wu, Zhengjun, Liu, Hong, Zhong, Dongsheng, Jiang, Rongcai, Sun, Jian, Tian, Ye, Wei, Yingsheng, An, Shuo, Wei, Pingbo, Luo, Le, Lin, Bin, Liu, Gang, Wen, Yan, Cai, Qiang, Chen, Qianxue, Lei, Pan, Li, Zhiyang, Zhang, Meifang, He, Jiaquan, Chen, Yan, Liu, Jun, Liu, Xinghai, Li, Junyan, Chen, Min, Wang, Jing, Zhou, Bingzhi, Ye, Baichun, Zhang, Jiancheng, Zhang, Manyuan, Pan, Xuming, Yu, Xiaoxiang, Xu, Jian, Xiao, Qingbao, Wang, Yuefei, Tao, Liang, Shi, Lin, Zheng, Niandong, You, Guoliang, Lei, Bo, Chen, Shu, Wu, Honggang, Hu, Jin, Zhao, Jianlan, Yu, Jian, Yuan, Qiang, Du, Zhuoying, Tang, Xielin, Li, Qianke, Liu, Shenghua, Yang, Feilong, Xiao, Kui, Luo, Chao, Wang, Guang, Che, Xudong, Teng, Zhipeng, Wan, Wenwu, Li, Jun, Liu, Yu, Fan, Mingbo, Zhang, Tao, Cai, Lun, Ma, Yuan, Ma, Zhifeng, Li, Bin, He, Linlin, Li, Jinghui, Zhang, Weibing, Zhang, Shuxin, Zhang, Hongzhen, Dai, Yingguang, Lei, Jun, Mao, Lei, Huang, Yiyang, Zhou, Zhi, Chen, Ping, Chen, Fang, Wei, Pan, Li, Tiangui, Chen, Honglin, Zeng, Mengfei, Mou, Kejie, Xue, Jun, Jiang, Yong, Tang, Xiaoping, Chen, Tao, Zhang, Yalan, Xu, Yanbing, Gu, Yuchen, Chen, Lei, Zhao, Yujun, Yang, Bin, Kuai, Peng, Wang, Xi, Yang, Yuwang, Hu, Xueling, Zhang, Huitian, Yang, Yintao, Wang, Weifeng, Zhang, Junyi, Cheng, Wei, Zhang, Xiaoxue, Ma, Xiaowen, He, Qin, Zhang, Li, Gao, Rong, Liu, Huixiang, Ye, Jingwei, Xu, Ping, Wu, Xin, Yuan, Yuan, Zou, Peng, Zhang, Zhen, Cheng, Jiyong, Zhou, Zhangming, Zeng, Yijun, Liang, Zhang, Du, Deming, Yu, Shui, Cao, Yongjun, Xu, Jiaping, Huang, Zhichao, Chen, Dongqin, Xiao, Wenfeng, Zhu, Li, Yuan, Miao, Wang, Yuhai, Shi, Dongliang, Hu, Xu, Xiang, Dingchao, Shi, Like, Wang, Hongqin, Yang, Liu, Miao, Wang, Hu, Yiyi, Zhao, Yuchun, Hu, Xi, Zhou, Weiduo, Sun, Chao, Tang, Dong, Yao, Kun, You, Jin, Chen, Shishi, Yao, Jianmin, Li, Huanmei, Liu, Jinmei, Bai, Ailin, Yi, Yong, Deng, Qingshan, Luo, Peng, Wang, Han, Jiang, Jingcheng, Yang, Qingwei, He, Shunpo, Wang, Jun, Chen, Yu, He, Hua, Deng, Yuyang, Cao, Zhikai, Yi, Xuxia, Luo, Jinbiao, Luo, Shuang, Gong, Min, Liu, Li, Gao, Xuejun, Liu, Jia, Wu, Li'e, Zhang, Jia, Sun, Hongying, Li, Xinhui, Jia, Lu, Wu, Jianbing, Zhang, Jie, Zhang, Huajun, Du, Chunfu, Li, Shun, Yang, Xiaobin, He, Jie, Liao, Lei, Zhou, Gezhi, Dong, Wentao, Chen, Yunxiang, Lin, Xiaofeng, Shui, Xujian, Zhang, Peng, Zhao, Yuan, Yang, Hongli, Zhao, Wenbin, Zhang, Xiaoyi, Chen, Jincao, Wu, Qian, Dai, Xuan, Tang, Baogui, Wang, Yinjuan, Liu, Tao, Zhang, Haixia, Duan, Faliang, Luo, Ming, Jiao, Qingfang, Lei, Guoliang, Wang, Dong, Song, Chunwang, Tan, Haopeng, Ye, Feng, Qin, Xinghu, Liang, Xiaolong, Liu, Junling, Yang, Lang, Yang, Jie, Lin, Yapeng, Yang, Qian, Ma, Xuntai, Qi, Yinkuang, Pan, Baogen, Jiang, Caixia, Ye, Zhanying, Dong, Ce, Yue, Xiongfei, Yang, Xiaopeng, Maimaitiyiming, Tuoheti, Dong, Jun, Wu, Yonggang, Gao, Feng, Zhao, Deqiang, Zhang, Xinghai, Wang, PengJun, Jiang, Hongbo, Li, Jianping, Zhang, Wei, Chen, Jing, Tong, Haibo, Wang, Yonghong, Qiao, Kaipeng, Guo, Fuyou, Zhang, Mingchu, Hu, Yan, Feng, Mengzhao, Song, Dengpan, Zuo, Yi, Chen, Shangjun, Qian, Chao, Li, Baoming, Ma, Jingku, Zhang, Sunfu, Kong, Bin, Dong, Xingyu, Fang, Sheng, Lu, Bin, Li, Yang, Yang, Yongling, Yu, Hong, Sun, Huaiyu, Wang, Yue, Wang, Weimin, Li, Tong, Li, Shengli, Xu, Zhiming, Wang, Yongyi, Dong, Qiang, Tang, Yuping, Chu, Heling, Lu, Ying, Wang, Zhong, Sun, Xiaoou, Zhao, Jianhua, Yang, Shuaifeng, Qian, Xiying, Saroja, Aralikatte Onkarappa, Naik k, Ravishankar, Chindhi, Sandip, Pampaniya, Nakul, Amaresh, Kurubara, Iype, Thomas, R, Dileep, Rajan, Reeja, Panicker, Praveen, Das, Rupjyoti, Choudhury, Nupur, Gohain, Pankaja, Webster, Jemin, Pakma, Biyol, Sangi, Lalbiak, Sebastian, Ivy, Aggrawal, Gaurav, Raj, Komal, Rajoura, Deepankshi, Singh, Sulena, Aggrawal, Varun, Narang, Amit, Arauz, Antonio, Cano-Nigenda, Vanesa, López-Mena, Diego, Valdez-Ruvalcaba, Héctor, Toledo-Treviño, Roberto, Obiako, Reginald, Abubakar, Sani, Emeka, Oguike, Olayemi, Balogun, Lois, Melika, Philip, Ibinaiye, Comfort O, Olurishe, Okubadejo, Njideka, Agabi, Osigwe, Ojo, Oluwadamilola, Wahab, Kolawole, Bello, Abiodun, Ibukun, Oyinloye, Sanayaolu, Olufemi, Jimoh, Abdulraheem, Waheed, Shahid, Kamal, Dr.Ayeesha, Shoaib, Raja Farhat, Orooj, Fizza, Majid, Sadaf, Zehra, Taskeen, Khan, Abdus Salam, Shanker, Ravi, Syed, Nadir Ali, Ahmad, Nashwa, Abanto, Carlos, Valencia, Ana, Barrientos, Danny, Ramirez, Jorge, Calle, Pilar, Palliyeguruge, Dilum, Muthucumarana, Sumudu, Ratnayaka, Shiroma, Ganihiarachchi, Dilhara, Bandaranayake, Arundathi, Somaratne, S.D.B, Narayana, Saumya, Gallage, Sithara, Senanayake, Bimsara, Samarasiri, Udari, Luke, Dunya, Sivapathasundaram, Mythily, Sahadevan, Vithoosan, Rasmi, Amani, Deshaka, Yuran, Fernando, Nilukshi, Munasinghe, Aruna, Rathnapriya, Kapilanga, Nissanka, A.S, Karunathilake, Kanchana, Gayan, Isuru, Wijenayake, Kaminda, Gunasekara, Hasitha, Vidyarathne, Jagath, Keshavaraj, Ajantha, Janarthanan, Kanagasabapathy, Gerald Jeevathasan, Arhivalaky, Sivamainthan, Sivaram, John Priyanth, Mathyamuthan, John Priyanth, Abirami, Rajendiran, Thambippillai, Alwis, Sanjeewa, Gunasekare, Nushara, Liyanarachchi, Vasundara, Dissanayake, Athula, Uluwattage, Wimalasiri Mewa, Ratnayake, Gimhani, Rajinee, Charika, Jayawardana, Sakura, Peiris, Janaka, Wicramasinghe, Ranjith, Fernando, Chamila, Abbas, Jessie, Withanage, Nethmini, Bandara, Makaranda, Mai, Duy Ton, Nguyen, Van Chi, Dao, Viet Phuong, Vuong, Xuan Trung, Nguyen, Tien Dung, Dinh, Trung Hieu, Phan, Ha Quan, Bui, Quoc Viet, Phung, Dinh Tho, Pham, Quang Tho, Pham, Dinh Dai, Do, Duc Thuan, Dang, Phuc Duc, Dang, Minh Duc, Nguyen, Dang Hai, Nguyen, Thi Phuong Nga, Nguyen, Quoc Huy, Pham, Quoc Dai, Chau, Quoc Vinh, Tai, Vinh Thy Van, Le, Tran Vinh, Le, Cong Tri, Tran, Ha Mai Khuong, Nguyen, Huu Khanh, Ngyen, Hoang Minh Thao, Vo, Duc Chien, Nguyen, Thai My Phuong, Tran, Trung Thanh, Vo, Thi Hanh Vi, Cao, Hao Nhien, Nguyen, Ba Thang, Le, Thi Ngoc Suong, La, Thien Duc, Pham, Chi Duc, Thai, Huy, Muñoz-Venturelli, Paula, de Silva, Asita, Thang, Nguyen Huy, Wahab, Kolawole W, Pandian, Jeyaraj D, Pontes-Neto, Octavio M, Shi, Haiping, Wang, Xia, Zhao, Yang, Li, Hao, Liu, Yi, Jiang, Yan, Wu, Bo, Liu, Ming, and Anderson, Craig S
Published: 2023
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3. The main Optimal Post rTpa-Iv Monitoring in Ischemic Stroke Trial (OPTIMISTmain): Protocol for a Pragmatic, Stepped Wedge, Cluster Randomized Controlled Trial.

Author: Ouyang, Menglu, Faigle, Roland, Wang, Xia, Johnson, Brenda, Summers, Debbie, Khatri, Pooja, Billot, Laurent, Liu, Hueiming, Malavera, Alejandra, Muñoz-Venturelli, Paula, González, Francisca, Urrutia, Francisca, Day, Diana, Song, Lili, Sui, Yi, Delcourt, Candice, Robinson, Thompson, Durham, Alice C., Ebraimo, Ahtasam, and Wan Zaidi, Wan Asyraf
Subjects: ISCHEMIC stroke, LENGTH of stay in hospitals, CEREBRAL hemorrhage, NEUROLOGIC examination, PATIENT monitoring, CLUSTER randomized controlled trials
Abstract: Introduction: Careful monitoring of patients who receive intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) is resource-intensive, and potentially less relevant in those with mild degrees of neurological impairment who are at low risk of symptomatic intracerebral hemorrhage (sICH) and other complications. Methods: OPTIMISTmain is an international, multicenter, prospective, stepped wedge, cluster randomized, blinded outcome assessed trial aims to determine whether a less-intensity monitoring protocol is at least as effective, safe, and efficient as standard post-IVT monitoring in patients with mild deficits post-AIS. Clinically stable adult patients with mild AIS (defined by a NIHSS <10) who do not require intensive care within 2 h post-IVT are recruited at hospitals in Australia, Chile, China, Malaysia, Mexico, UK, USA, and Vietnam. An average of 15 patients recruited per period (overall 60 patient participants) at 120 sites for a total of 7,200 IVT-treated AIS patients will provide 90% power (one-sided α 0.025). The initiation of eligible hospitals is based on a rolling process whenever ready, stratified by country. Hospitals are randomly allocated using permuted blocks into 3 sequences of implementation, stratified by country and the projected number of patients to be recruited over 12 months. These sequences have four periods that dictate the order in which they are to switch from control (usual care) to intervention (implementation of low intensity monitoring protocol) to different clusters of patients in a stepped manner. Compared to standard monitoring, the low-intensity monitoring protocol includes assessments of neurological and vital signs every 15 min for 2 h, 2 hourly (vs. every 30 min) for 8 h, and 4 hourly (vs. every 1 h) until 24 h, post-IVT. The primary outcome measure is functional recovery, defined by the modified Rankin scale (mRS) at 90 days, a seven-point ordinal scale (0 [no residual symptom] to 6 [death]). Secondary outcomes include death or dependency, length of hospital stay, and health-related quality of life, sICH, and serious adverse events. Conclusion: OPTIMISTmain will provide level I evidence for the safety and effectiveness of a low-intensity post-IVT monitoring protocol in patients with mild severity of AIS. [ABSTRACT FROM AUTHOR]
Published: 2024
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4. Implementation of Low-Intensity Thrombolysis Monitoring Care in Routine Practice: Process Evaluation of the Optimal Post rtPA-IV Monitoring in Acute Ischemic Stroke Study in the USA

Author: Ouyang, Menglu, primary, González, Francisca, additional, Montalbano, Michelle, additional, Pruski, April, additional, Jan, Stephen, additional, Wang, Xia, additional, Johnson, Brenda, additional, Summers, Debbie V., additional, Khatri, Pooja, additional, Malavera, Alejandra, additional, Iacobelli, Michael, additional, Faigle, Roland, additional, Munoz-Venturelli, Paula, additional, Urrutia Goldsack, Francisca, additional, Day, Diana, additional, Robinson, Thompson G., additional, Durham, Alice C., additional, Ebraimo, Ahtasam, additional, Song, Lili, additional, Sui, Yi, additional, Wan Zaidi, Wan Asyraf, additional, Lindley, Richard I., additional, Delcourt, Candice, additional, Urrutia, Victor Cruz, additional, Anderson, Craig S., additional, and Liu, Hueiming, additional
Published: 2024
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5. Combined utility of blood glucose and white blood cell in predicting outcome after acute ischemic stroke: The ENCHANTED trial

Author: Xia, Chao, Wang, Xia, Lindley, Richard I., Delcourt, Candice, Zhou, Zien, Chen, Xiaoying, Carcel, Cheryl, Malavera, Alejandra, Calic, Zeljka, and Anderson, Craig S.
Published: 2020
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6. Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Author: Hankey, Graeme J., Hackett, Maree L., Almeida, Osvaldo P., Flicker, Leon, Mead, Gillian E., Dennis, Martin S., Etherton-Beer, Christopher, Ford, Andrew H., Billot, Laurent, Jan, Stephen, Lung, Thomas, Murray, Veronica, Lundström, Erik, Anderson, Craig S., Herbert, Robert, Carter, Gregory, Donnan, Geoffrey A., Nguyen, Huy-Thang, Gommans, John, Yi, Qilong, Li, Qiang, Bompoint, Severine, Barrett, Sarah, Claxton, Anne, O'Dea, Julia, Tang, Michelle, Williams, Clare, Peterson, Shenae, Drummond, Christie, Hong, Uyen-Ha, Le, Linh-Thi My, Ngo, Tram-Thi Bich, Mai, Yen-Bao, Han, Huyen-Thanh, Truong, Nhu-Quynh, Nguyen, Huong-Thi, Ngo, Hai-Thanh, Nguyen, -Thi Binh, Ha, Oanh-Thi Kieu, Nguyen, Trang-Le Huyen, Lindley, Richard I., New, Peter, Lee, Andrew, Tran, Thanh-Trung, Le, Loan-Tran Truc Mai, Kieu, Thuy-Le Vu, Nguyen, Sang-Van, Nguyen, Thuy-Anh Diem, Dang, Tam-Nhat, Phan, Hanh-Thi Truc, Vo, Loan-Thi Ngoc, Nguyen, Mai-Hue, Dang, Hanh-Cao, Tran, Hong-Thi, Dam, Linh-Thi Cam, Ngo, Trinh-Thi Kim, Pham, Thai-Nguyen Thanh, Pham, Binh-Nguyen, Dao, Nha-Thi Thanh, Nguyen, Huong-Thi Bich, Le, Linh-Thi Cam, Do, Chi-Minh, Huynh, Huy-Quoc, Tran, Giau-Thi Kim, Le, Oanh-Thi, Tran, Ly-Thi Khanh, Duong, Chinh-Dinh, Kieu, Duong-Van, Le, Na, Nguyen, Hoa-Ngoc, Le, Binh-Van, Nguyen, Long-Thanh, Nguyen, Long-Van, Dinh, Tuan-Quoc, Vo, Tan-Van, Bui, Tram-Ngoc, Hoang, Uyen-Thi To, Nguyen, Hien-Thi Bich, Nguyen, Ha-Thi Thu, Lam, Nga-Thuy, Le, Khanh-Kim, Trinh, Phuong-Thanh, Huynh, Hop-Quang, Nguyen, Thao-Thi Thu, Lu, Huyen-Ngoc, Pham, Tham-Hong, Nguyen, Sam-Hoanh, Le, Ninh-Hong, Nguyen, Giang-Truong, Doan, Bich-Thi, Pham, Sung-Phuoc, Luong, Duong-Huu, Mai, Ha-Van, Tran, Thuc-Van, Do, Phuong-Thi, Le, Hoai-Thi, Nguyen, Chi-Van, Nguyen, Phuong-Doan, Mai, Ton-Duy, Dao, Phuong-Viet, Nguyen, Dung-Tien, Khuong, Dai-Quoc, Vuong, Trung-Xuan, Vu, Lan-Tuong, Ngo, Ngoc-Duc, Dang, Hanh-Hong, Truong, Phuong-Thai, Le, Ngan-Thi, Hoang, Hoa-Van, Do, Chung-Quang, Nguyen, Minh-Thao, Dam, Anh-Hai, Le, Quynh-Nhu, Nguyen, Ngoc-Hoang, Nguyen, Tuyen-Van, Le, Toan-Dinh, Dinh, Ha-Thi Hai, Pham, Cuong-Van, Thach, Khanh-Thi Ngoc, Nguyen, Linh-Hai, Nguyen, Loan-Thi, Le, Vien-Chi, Tran, Phuong-Hong, Nguyen, Tai-Anh, Le, Tuan-Van, Truong, Luyen-Van, Bui, Tue-Chau, Huynh, Ngoc-Xuan, Dinh, Lap-Van, Pham, An-Gia, Le, Trang-Thi Huyen, Nguyen, Vy-Tuong, Nguyen, Yen-Hai, Nguyen, Thang-Ba, Thai, Huy, Pham, Quyen-Thi Ngoc, Dao, Khoa-Duy, Pham, Quoc-Nguyen Bao, Dang, Thuong-Thi Huyen, Dinh, Huong-Huynh To, Tong, Trang-Mai, Vu, Thuy-Thi, Le, Si-Tri, Tran, Tai-Ngoc, Tran, Phuong-Hoai, Dinh, Ngoc-Thuy Nhu, Nguyen, Binh-Thanh, Do, Vinh-Phuong, Nguyen, Anh-Ngoc, Nguyen, Binh-Thi Thanh, Blacker, David, Bunce, Lindsey, Tan, Ai Ling, Ghia, Darshan, Edmonds, Gillian, O'Loughlin, Nicole, Ewing, Megan, Whittaker, Kerri-Ann, Deane, Lorralee, Gawarikar, Yash, Jones, Brett, Lopez, Maria, Nagesh, Koushik, Siracusa, Emma, Davis, Stephen, McDonald, Amy, Tsoleridis, Jess, McCoy, Rachael, Jackson, David, Silver, Gab, Bates, Timothy R., Boudville, Amanda, Southwell, Lynda, Cordato, Dennis, McDougall, Alan J., Cappelen-Smith, Cecilia, Calic, Zeljka, Askar, Shabeel, Cheng, Qi, Kumar, Raymond, Geraghty, Richard, Duroux, Maree, Ratcliffe, Megan, Shone, Samantha, McLennan, Cassandra, Sahathevan, Ramesh, Hair, Casey, Levy, Stanley, Macdonald, Beverley, Nham, Benjamin, Rigney, Louise, Nathani, Dev, Gopinath, Sumana, Patel, Vishal, Mamun, Abul, Trewin, Benjamin, Phua, Chun, Choong, Ho, Tarrant, Lauren, Boyle, Kerry, Hewitt, Luisa, Hourn, Monique, Masterson, Amanda, Oakley, Kim, Ruddell, Karen, Sanctuary, Colette, Veitch, Kimberley, Burdusel, Camelia, Lee, Lina, Cheuk, Gary, Christley, Jeremy, Hartwell, Tabitha, Davenport, Craig, Hickey, Kate, Robertson, Rosanna, Carr, Michelle, Akbari, Sam, Coyle, Hannah, O'Neill, Megan, Redpath, Cameron, Roberts, Caroline, Tabesh, Marjan, Withiel, Toni, Abeysuriya, Kapila, Granger, Andrew, Abraham, Angela, Chua, Chermaine, Do Nguyen, Dung, Surendran, Vathani, Daines, Melissa, Shivlal, David, Latif, Mudassar, Mughal, Noreen, Morgan, Patricia, Krause, Martin, Priglinger, Miriam, Shandiz, Ehsan E., Day, Susan, Kho, Lay, Pollack, Michael, Dunne, Judith, Baines, Helen, Rees, Merridie, White, Jenni, Withanage, Aicuratiya, Delcourt, Candice, Carcel, Cheryl, Malavera, Alejandra, Kunchok, Amy, Ray, Elizabeth, Pepper, Elizabeth, Duckett, Emily, Ormond, Sally, Moey, Andrew, Kleinig, Timothy, Maxwell, Vanessa, Baldwin, Chantal, Vallat, Wilson, Field, Deborah, Markus, Romesh, Page, Kirsty, Wheelwright, Danielle, Bolitho, Sam, Faux, Steven, Sangvatanakul, Fix, Brown, Alexis, Walker, Susan, Massey, Jennifer, Hayes, Hillary, Katrak, Pesi, Winker, Annie, Zagami, Alessandro, Bailey, Alanah, Mccormack, Sarah, Murray, Andrew, Rollason, Mark, Taylor, Christopher, O'Rourke, Fintan, Kuang, Ye Min, Burnet, Heike, Liu, Yvonne, Wu, Aileen, Ramirez, Diana, Wijeratne, Tissa, Celestino, Sherisse, Low, Essie, Chen, Cynthia, Bergqvist, Jennifer, Evans, Andrew, Leung, Queenie, Jude, Martin, McQueen, Rachael, Mohr, Katherine, Kernaghan, Latitia, Stockle, Paul, Tan, Boon L., Laubscher, Sara, Schmid, Diana, Spooner, Melissa, Lallu, Bhavesh, Pepperell, Bronwen, Chalissery, John, Mahawish, Karim, DeCaigney, Susan, Broughton, Paula, Knight, Karen, Duque, Veronica, McNaughton, Harry, Lanford, Jeremy, Fu, Vivian, and Wong, Lai-Kin
Published: 2020
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7. Early decompressive hemicraniectomy in thrombolyzed acute ischemic stroke patients from the international ENCHANTED trial

Author: Xia, Chao, Wang, Xia, Lindley, Richard I., Delcourt, Candice, Chen, Xiaoying, Zhou, Zien, Guo, Rui, Carcel, Cheryl, Malavera, Alejandra, Calic, Zeljka, Mair, Grant, Wardlaw, Joanna M., Robinson, Thompson G., and Anderson, Craig S.
Published: 2021
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8. The main Optimal Post rTpa-Iv Monitoring in Ischemic Stroke Trial (OPTIMISTmain): protocol for a pragmatic, stepped wedge, cluster randomized controlled trial

Author: Ouyang, Menglu, primary, Faigle, Roland, additional, Wang, Xia, additional, Johnson, Brenda, additional, Summers, Debbie, additional, Khatri, Pooja, additional, Billot, Laurent, additional, Liu, Hueiming, additional, Malavera, Alejandra, additional, Munoz-Venturelli, Paula, additional, Gonzalez, Francisca, additional, Urrutia, Francisca, additional, Day, Diana, additional, Song, Lili, additional, Sui, Yi, additional, Delcourt, Candice, additional, Robinson, Thompson, additional, Durham, Alice C., additional, Ebraimo, Ahtasam, additional, Wan Zaidi, Wan Asyraf, additional, Jan, Stephen, additional, Lindley, Richard I., additional, Urrutia, Victor C., additional, and Anderson, Craig S., additional
Published: 2023
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9. Cross-modal cueing effects of visuospatial attention on conscious somatosensory perception

Author: Doruk, Deniz, Chanes, Lorena, Malavera, Alejandra, Merabet, Lotfi B., Valero-Cabré, Antoni, and Fregni, Felipe
Published: 2018
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10. Thrombolysis Outcomes in Acute Ischemic Stroke by Fluid-Attenuated Inversion Recovery Hyperintense Arteries

Author: Zhou, Zien, Yoshimura, Sohei, Delcourt, Candice, Lindley, Richard I., You, Shoujiang, Malavera, Alejandra, Torii-Yoshimura, Takako, Carcel, Cheryl, Wang, Xia, Chen, Xiaoying, Parsons, Mark W., Demchuk, Andrew M., Wardlaw, Joanna M., Mair, Grant, Robinson, Thompson G., Chalmers, John, Xu, Jianrong, and Anderson, Craig S.
Published: 2020
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11. The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial

Author: Ma, Lu, primary, Hu, Xin, additional, Song, Lili, additional, Chen, Xiaoying, additional, Ouyang, Menglu, additional, Billot, Laurent, additional, Li, Qiang, additional, Malavera, Alejandra, additional, Li, Xi, additional, Muñoz-Venturelli, Paula, additional, de Silva, Asita, additional, Thang, Nguyen Huy, additional, Wahab, Kolawole W, additional, Pandian, Jeyaraj D, additional, Wasay, Mohammad, additional, Pontes-Neto, Octavio M, additional, Abanto, Carlos, additional, Arauz, Antonio, additional, Shi, Haiping, additional, Tang, Guanghai, additional, Zhu, Sheng, additional, She, Xiaochun, additional, Liu, Leibo, additional, Sakamoto, Yuki, additional, You, Shoujiang, additional, Han, Qiao, additional, Crutzen, Bernard, additional, Cheung, Emily, additional, Li, Yunke, additional, Wang, Xia, additional, Chen, Chen, additional, Liu, Feifeng, additional, Zhao, Yang, additional, Li, Hao, additional, Liu, Yi, additional, Jiang, Yan, additional, Chen, Lei, additional, Wu, Bo, additional, Liu, Ming, additional, Xu, Jianguo, additional, You, Chao, additional, Anderson, Craig S, additional, Robinson, Thompson, additional, Miranda, J. Jaime, additional, Anderson, Craig S., additional, Parry-Jones, Adrian, additional, Sprigg, Nikola, additional, Durrans, Sophie, additional, Harris, Caroline, additional, Bamford, Ann, additional, Smith, Olivia, additional, Herbert, Robert, additional, Chen, Christopher, additional, Whiteley, William, additional, Hu, Rong, additional, Mysore, Jayanthi, additional, Zhang, Yao, additional, Jan, Stephen, additional, Liu, Hueiming, additional, Sun, Lingli, additional, Chu, Honglin, additional, Anjum, Anila, additional, Gonzalez Mc Cawley, Francisca, additional, Del Rio, Alejandra, additional, Rimoli, Bruna, additional, Cerantola, Rodrigo, additional, Jeevarajah, Thanushanthan, additional, Kannangara, Madhushani, additional, Joseph, Andrene, additional, Nanayakkara, Chamath, additional, Zhang, Chunmiao, additional, Yang, Zhao, additional, Li, Brook, additional, Meng, Zhuo, additional, Ning, Yi, additional, Dong, Le, additional, Armenis, Manuela, additional, Lim, Joyce, additional, Monaghan, Helen, additional, Ma, Lu, additional, Luo, Rui, additional, Cheng, Guojuan, additional, Dong, Yilin, additional, Liu, Ziqin, additional, Wang, Shuihong, additional, Zhang, Ying, additional, Cheng, Jipeng, additional, Shi, Hui, additional, Li, Wenjing, additional, Mou, Langming, additional, Yi, Ping, additional, Chen, Xue, additional, Weerawardena, Shalomi, additional, Ellawala, Poornima, additional, Ranasinghe, Enalee, additional, Rodrigo, Chrishmi, additional, Wahab, Kolawala, additional, Adeniyi, Sunday, additional, Pandian, Jeyaraj, additional, Khanna, Megha, additional, Muñoz Venturelli, Paula, additional, González, Francisca, additional, Urrutia Goldsack, Francisca, additional, Begum, Dilshad, additional, Pontes-Neto, Octavio, additional, Camilo, Millene, additional, Dias, Francisco, additional, Vincenzi, Octavio, additional, Moro, Carla, additional, Santos, Renata, additional, Texeira, Nara, additional, Longo, Alexandre, additional, Liberato, Rafaela, additional, Martins, Sheila, additional, Pille, Arthur, additional, Chwal, Bruna, additional, Silva, Isabel, additional, Titton, Natacha, additional, Weiss, Gustavo, additional, Mora, Daissy, additional, Ouriques, Magda, additional, Carbonera, Leonardo, additional, Bazan, Rodrigo, additional, Modolo, Gabriel, additional, Winckler, Fernanda, additional, Miranda, Luana, additional, Souza, Juli, additional, Rojo, Alexis, additional, Uslar, Wilhelm, additional, Medel, Lorena, additional, Lopez, Javiera, additional, Herrero, Diego, additional, Lavados, Pablo, additional, Vargas Latorre, Barbara, additional, Conejan, Nathalie, additional, Esparza, Tomas, additional, Sotomayor, Patricio, additional, Wenger, Denisse, additional, Gigoux, Juan Pablo, additional, Letelier, Aldo, additional, Acevedo, Lilian, additional, Moya, Vivianne, additional, Figueroa, Cristian, additional, Vallejos, Nicol, additional, Guerrero, Rodrigo, additional, Velasquez, Mauricio, additional, Vallejos, Jose, additional, Pallauta, Kimerly, additional, Santibanez, Tamara, additional, Queirolo, Angelo, additional, Lobos, Andrea, additional, Jiang, Yongming, additional, Li, Weimin, additional, Huang, Wei, additional, Luo, Ke, additional, Liu, Gangying, additional, Yang, Guang, additional, Jiang, Hongtao, additional, Zhang, Xu, additional, Jing, Hongyan, additional, Pu, Bo, additional, Lv, Dong, additional, Kang, Hui, additional, Hu, Qiuping, additional, Jiang, Xiaoming, additional, Chen, Yanli, additional, Yang, Shenghua, additional, He, Jianjun, additional, Li, Zongping, additional, Cheng, Gang, additional, Huang, Hailin, additional, Wang, Xiaoyi, additional, Lin, Jianqiong, additional, Chen, Minhui, additional, Yang, Chenghao, additional, Ding, Hao, additional, Deng, Yunliang, additional, Luo, Fei, additional, Zhang, Rongjun, additional, Wang, Xiaofeng, additional, Zhang, Hongbing, additional, Yang, Xiaoliang, additional, Zhang, Yang, additional, Yang, Chengyi, additional, He, Yu, additional, Liu, Feng, additional, Wang, Rongjie, additional, Zhang, Yuhui, additional, Xin, Xiaodong, additional, Feng, Bin, additional, Hao, Wanru, additional, Song, Chang, additional, Guo, Yun, additional, Jiang, Dehua, additional, Chen, Jie, additional, Tang, Changtong, additional, Zhu, Hongliang, additional, Li, Xin, additional, Cui, Jin, additional, Xu, Haidong, additional, Li, Boyang, additional, Tang, Fusheng, additional, Li, Yuanbin, additional, Gao, Min, additional, Yang, Bo, additional, Xu, Xuejun, additional, Deng, Bing, additional, Zheng, Yi, additional, Ge, Yuanhong, additional, Chen, Keyu, additional, Liu, Yang, additional, Li, Xinshen, additional, Zhong, Tingting, additional, Xu, Jianfeng, additional, Zhang, Hai, additional, Wang, Jiyue, additional, Zhu, Jianxin, additional, Sun, Hanyu, additional, Yu, Fuhua, additional, Zhang, Xueguang, additional, Zhang, Mingsen, additional, Wang, Bin, additional, Ma, Yiming, additional, Jiang, Donglin, additional, Zhou, Jun, additional, Liu, Cong, additional, Nie, Wenhong, additional, Li, Mingguo, additional, Tian, Tao, additional, Li, Yong, additional, He, Mingfang, additional, Tu, Xiaolong, additional, Wu, Zhengjun, additional, Liu, Hong, additional, Zhong, Dongsheng, additional, Jiang, Rongcai, additional, Sun, Jian, additional, Tian, Ye, additional, Wei, Yingsheng, additional, An, Shuo, additional, Wei, Pingbo, additional, Luo, Le, additional, Lin, Bin, additional, Liu, Gang, additional, Wen, Yan, additional, Cai, Qiang, additional, Chen, Qianxue, additional, Lei, Pan, additional, Li, Zhiyang, additional, Zhang, Meifang, additional, He, Jiaquan, additional, Chen, Yan, additional, Liu, Jun, additional, Liu, Xinghai, additional, Li, Junyan, additional, Chen, Min, additional, Wang, Jing, additional, Zhou, Bingzhi, additional, Ye, Baichun, additional, Zhang, Jiancheng, additional, Zhang, Manyuan, additional, Pan, Xuming, additional, Yu, Xiaoxiang, additional, Xu, Jian, additional, Xiao, Qingbao, additional, Wang, Yuefei, additional, Tao, Liang, additional, Shi, Lin, additional, Zheng, Niandong, additional, You, Guoliang, additional, Lei, Bo, additional, Chen, Shu, additional, Wu, Honggang, additional, Hu, Jin, additional, Zhao, Jianlan, additional, Yu, Jian, additional, Yuan, Qiang, additional, Du, Zhuoying, additional, Tang, Xielin, additional, Li, Qianke, additional, Liu, Shenghua, additional, Yang, Feilong, additional, Xiao, Kui, additional, Luo, Chao, additional, Wang, Guang, additional, Che, Xudong, additional, Teng, Zhipeng, additional, Wan, Wenwu, additional, Li, Jun, additional, Liu, Yu, additional, Fan, Mingbo, additional, Zhang, Tao, additional, Cai, Lun, additional, Ma, Yuan, additional, Ma, Zhifeng, additional, Li, Bin, additional, He, Linlin, additional, Li, Jinghui, additional, Zhang, Weibing, additional, Zhang, Shuxin, additional, Zhang, Hongzhen, additional, Dai, Yingguang, additional, Lei, Jun, additional, Mao, Lei, additional, Huang, Yiyang, additional, Zhou, Zhi, additional, Chen, Ping, additional, Chen, Fang, additional, Wei, Pan, additional, Li, Tiangui, additional, Chen, Honglin, additional, Zeng, Mengfei, additional, Mou, Kejie, additional, Xue, Jun, additional, Jiang, Yong, additional, Tang, Xiaoping, additional, Chen, Tao, additional, Zhang, Yalan, additional, Xu, Yanbing, additional, Gu, Yuchen, additional, Zhao, Yujun, additional, Yang, Bin, additional, Kuai, Peng, additional, Wang, Xi, additional, Yang, Yuwang, additional, Hu, Xueling, additional, Zhang, Huitian, additional, Yang, Yintao, additional, Wang, Weifeng, additional, Zhang, Junyi, additional, Cheng, Wei, additional, Zhang, Xiaoxue, additional, Ma, Xiaowen, additional, He, Qin, additional, Zhang, Li, additional, Gao, Rong, additional, Liu, Huixiang, additional, Ye, Jingwei, additional, Xu, Ping, additional, Wu, Xin, additional, Yuan, Yuan, additional, Zou, Peng, additional, Zhang, Zhen, additional, Cheng, Jiyong, additional, Zhou, Zhangming, additional, Zeng, Yijun, additional, Liang, Zhang, additional, Du, Deming, additional, Yu, Shui, additional, Cao, Yongjun, additional, Xu, Jiaping, additional, Huang, Zhichao, additional, Chen, Dongqin, additional, Xiao, Wenfeng, additional, Zhu, Li, additional, Yuan, Miao, additional, Wang, Yuhai, additional, Shi, Dongliang, additional, Hu, Xu, additional, Xiang, Dingchao, additional, Shi, Like, additional, Wang, Hongqin, additional, Yang, Liu, additional, Miao, Wang, additional, Hu, Yiyi, additional, Zhao, Yuchun, additional, Hu, Xi, additional, Zhou, Weiduo, additional, Sun, Chao, additional, Tang, Dong, additional, Yao, Kun, additional, You, Jin, additional, Chen, Shishi, additional, Yao, Jianmin, additional, Li, Huanmei, additional, Liu, Jinmei, additional, Bai, Ailin, additional, Yi, Yong, additional, Deng, Qingshan, additional, Luo, Peng, additional, Wang, Han, additional, Jiang, Jingcheng, additional, Yang, Qingwei, additional, He, Shunpo, additional, Wang, Jun, additional, Chen, Yu, additional, He, Hua, additional, Deng, Yuyang, additional, Cao, Zhikai, additional, Yi, Xuxia, additional, Luo, Jinbiao, additional, Luo, Shuang, additional, Gong, Min, additional, Liu, Li, additional, Gao, Xuejun, additional, Liu, Jia, additional, Wu, Li'e, additional, Zhang, Jia, additional, Sun, Hongying, additional, Li, Xinhui, additional, Jia, Lu, additional, Wu, Jianbing, additional, Zhang, Jie, additional, Zhang, Huajun, additional, Du, Chunfu, additional, Li, Shun, additional, Yang, Xiaobin, additional, He, Jie, additional, Liao, Lei, additional, Zhou, Gezhi, additional, Dong, Wentao, additional, Chen, Yunxiang, additional, Lin, Xiaofeng, additional, Shui, Xujian, additional, Zhang, Peng, additional, Zhao, Yuan, additional, Yang, Hongli, additional, Zhao, Wenbin, additional, Zhang, Xiaoyi, additional, Chen, Jincao, additional, Wu, Qian, additional, Dai, Xuan, additional, Tang, Baogui, additional, Wang, Yinjuan, additional, Liu, Tao, additional, Zhang, Haixia, additional, Duan, Faliang, additional, Luo, Ming, additional, Jiao, Qingfang, additional, Lei, Guoliang, additional, Wang, Dong, additional, Song, Chunwang, additional, Tan, Haopeng, additional, Ye, Feng, additional, Qin, Xinghu, additional, Liang, Xiaolong, additional, Liu, Junling, additional, Yang, Lang, additional, Yang, Jie, additional, Lin, Yapeng, additional, Yang, Qian, additional, Ma, Xuntai, additional, Qi, Yinkuang, additional, Pan, Baogen, additional, Jiang, Caixia, additional, Ye, Zhanying, additional, Dong, Ce, additional, Yue, Xiongfei, additional, Yang, Xiaopeng, additional, Maimaitiyiming, Tuoheti, additional, Dong, Jun, additional, Wu, Yonggang, additional, Gao, Feng, additional, Zhao, Deqiang, additional, Zhang, Xinghai, additional, Wang, PengJun, additional, Jiang, Hongbo, additional, Li, Jianping, additional, Zhang, Wei, additional, Chen, Jing, additional, Tong, Haibo, additional, Wang, Yonghong, additional, Qiao, Kaipeng, additional, Guo, Fuyou, additional, Zhang, Mingchu, additional, Hu, Yan, additional, Feng, Mengzhao, additional, Song, Dengpan, additional, Zuo, Yi, additional, Chen, Shangjun, additional, Qian, Chao, additional, Li, Baoming, additional, Ma, Jingku, additional, Zhang, Sunfu, additional, Kong, Bin, additional, Dong, Xingyu, additional, Fang, Sheng, additional, Lu, Bin, additional, Li, Yang, additional, Yang, Yongling, additional, Yu, Hong, additional, Sun, Huaiyu, additional, Wang, Yue, additional, Wang, Weimin, additional, Li, Tong, additional, Li, Shengli, additional, Xu, Zhiming, additional, Wang, Yongyi, additional, Dong, Qiang, additional, Tang, Yuping, additional, Chu, Heling, additional, Lu, Ying, additional, Wang, Zhong, additional, Sun, Xiaoou, additional, Zhao, Jianhua, additional, Yang, Shuaifeng, additional, Qian, Xiying, additional, Saroja, Aralikatte Onkarappa, additional, Naik k, Ravishankar, additional, Chindhi, Sandip, additional, Pampaniya, Nakul, additional, Amaresh, Kurubara, additional, Iype, Thomas, additional, R, Dileep, additional, Rajan, Reeja, additional, Panicker, Praveen, additional, Das, Rupjyoti, additional, Choudhury, Nupur, additional, Gohain, Pankaja, additional, Webster, Jemin, additional, Pakma, Biyol, additional, Sangi, Lalbiak, additional, Sebastian, Ivy, additional, Aggrawal, Gaurav, additional, Raj, Komal, additional, Rajoura, Deepankshi, additional, Singh, Sulena, additional, Aggrawal, Varun, additional, Narang, Amit, additional, Cano-Nigenda, Vanesa, additional, López-Mena, Diego, additional, Valdez-Ruvalcaba, Héctor, additional, Toledo-Treviño, Roberto, additional, Obiako, Reginald, additional, Abubakar, Sani, additional, Emeka, Oguike, additional, Olayemi, Balogun, additional, Lois, Melika, additional, Philip, Ibinaiye, additional, Comfort O, Olurishe, additional, Okubadejo, Njideka, additional, Agabi, Osigwe, additional, Ojo, Oluwadamilola, additional, Wahab, Kolawole, additional, Bello, Abiodun, additional, Ibukun, Oyinloye, additional, Sanayaolu, Olufemi, additional, Jimoh, Abdulraheem, additional, Waheed, Shahid, additional, Kamal, Dr.Ayeesha, additional, Shoaib, Raja Farhat, additional, Orooj, Fizza, additional, Majid, Sadaf, additional, Zehra, Taskeen, additional, Khan, Abdus Salam, additional, Shanker, Ravi, additional, Syed, Nadir Ali, additional, Ahmad, Nashwa, additional, Valencia, Ana, additional, Barrientos, Danny, additional, Ramirez, Jorge, additional, Calle, Pilar, additional, Palliyeguruge, Dilum, additional, Muthucumarana, Sumudu, additional, Ratnayaka, Shiroma, additional, Ganihiarachchi, Dilhara, additional, Bandaranayake, Arundathi, additional, Somaratne, S.D.B, additional, Narayana, Saumya, additional, Gallage, Sithara, additional, Senanayake, Bimsara, additional, Samarasiri, Udari, additional, Luke, Dunya, additional, Sivapathasundaram, Mythily, additional, Sahadevan, Vithoosan, additional, Rasmi, Amani, additional, Deshaka, Yuran, additional, Fernando, Nilukshi, additional, Munasinghe, Aruna, additional, Rathnapriya, Kapilanga, additional, Nissanka, A.S, additional, Karunathilake, Kanchana, additional, Gayan, Isuru, additional, Wijenayake, Kaminda, additional, Gunasekara, Hasitha, additional, Vidyarathne, Jagath, additional, Keshavaraj, Ajantha, additional, Janarthanan, Kanagasabapathy, additional, Gerald Jeevathasan, Arhivalaky, additional, Sivamainthan, Sivaram, additional, John Priyanth, Mathyamuthan, additional, John Priyanth, Abirami, additional, Rajendiran, Thambippillai, additional, Alwis, Sanjeewa, additional, Gunasekare, Nushara, additional, Liyanarachchi, Vasundara, additional, Dissanayake, Athula, additional, Uluwattage, Wimalasiri Mewa, additional, Ratnayake, Gimhani, additional, Rajinee, Charika, additional, Jayawardana, Sakura, additional, Peiris, Janaka, additional, Wicramasinghe, Ranjith, additional, Fernando, Chamila, additional, Abbas, Jessie, additional, Withanage, Nethmini, additional, Bandara, Makaranda, additional, Mai, Duy Ton, additional, Nguyen, Van Chi, additional, Dao, Viet Phuong, additional, Vuong, Xuan Trung, additional, Nguyen, Tien Dung, additional, Dinh, Trung Hieu, additional, Phan, Ha Quan, additional, Bui, Quoc Viet, additional, Phung, Dinh Tho, additional, Pham, Quang Tho, additional, Pham, Dinh Dai, additional, Do, Duc Thuan, additional, Dang, Phuc Duc, additional, Dang, Minh Duc, additional, Nguyen, Dang Hai, additional, Nguyen, Thi Phuong Nga, additional, Nguyen, Quoc Huy, additional, Pham, Quoc Dai, additional, Chau, Quoc Vinh, additional, Tai, Vinh Thy Van, additional, Le, Tran Vinh, additional, Le, Cong Tri, additional, Tran, Ha Mai Khuong, additional, Nguyen, Huu Khanh, additional, Ngyen, Hoang Minh Thao, additional, Vo, Duc Chien, additional, Nguyen, Thai My Phuong, additional, Tran, Trung Thanh, additional, Vo, Thi Hanh Vi, additional, Cao, Hao Nhien, additional, Nguyen, Ba Thang, additional, Le, Thi Ngoc Suong, additional, La, Thien Duc, additional, Pham, Chi Duc, additional, and Thai, Huy, additional
Published: 2023
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12. Duration Dependent Effects of Transcranial Pulsed Current Stimulation (tPCS) Indexed by Electroencephalography

Author: Vasquez, Alejandra, Malavera, Alejandra, Doruk, Deniz, Morales-Quezada, Leon, Carvalho, Sandra, Leite, Jorge, and Fregni, Felipe
Published: 2016
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13. Repetitive Transcranial Magnetic Stimulation for Phantom Limb Pain in Land Mine Victims: A Double-Blinded, Randomized, Sham-Controlled Trial

Author: Malavera, Alejandra, Silva, Federico Arturo, Fregni, Felipe, Carrillo, Sandra, and Garcia, Ronald G.
Published: 2016
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14. Peripheral Neuropathy

Author: Stavale, Rafaelly, primary, Jones, Felipe, additional, Malavera, Alejandra, additional, and Fregni, Felipe, additional
Published: 2018
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15. sj-pdf-1-cep-10.1177_03331024231183166 - Supplemental material for The effect of blood pressure lowering medications on the prevention of episodic migraine: A systematic review and meta-analysis

Author: Carcel, Cheryl, Haghdoost, Faraidoon, Shen, Joanne, Nanda, Puneet, Bai, Yu, Atkins, Emily, Torii-Yoshimura, Takako, Clough, Alexander J., Davies, Leo, Cordato, Dennis, Griffiths, Lyn R., Balicki, Grace, Wang, Xia, Vidyasagar, Kota, Malavera, Alejandra, Anderson, Craig S., Zagami, Alessandro S., Delcourt, Candice, and Rodgers, Anthony
Subjects: FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 110306 Endocrinology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract: Supplemental material, sj-pdf-1-cep-10.1177_03331024231183166 for The effect of blood pressure lowering medications on the prevention of episodic migraine: A systematic review and meta-analysis by Cheryl Carcel, Faraidoon Haghdoost, Joanne Shen, Puneet Nanda, Yu Bai, Emily Atkins, Takako Torii-Yoshimura, Alexander J. Clough, Leo Davies, Dennis Cordato, Lyn R. Griffiths, Grace Balicki, Xia Wang, Kota Vidyasagar, Alejandra Malavera, Craig S. Anderson, Alessandro S. Zagami, Candice Delcourt and Anthony Rodgers in Cephalalgia
Published: 2023
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16. Process evaluation of complex interventions in non-communicable and neglected tropical diseases in low- and middle-income countries: a scoping review

Author: Lazo-Porras, Maria, Liu, Hueiming, Ouyang, Menglu, Yin, Xuejun, Malavera, Alejandra, Bressan, Tiana, Guzman-Vilca, Wilmer Cristobal, Pacheco, Niels, Benito, Melissa, Miranda, J Jaime, Moore, Graham, Chappuis, François, Perel, Pablo, and Beran, David
Abstract: Objectives The aim of this review is to map out the use of process evaluation (PE) in complex interventions that address non-communicable diseases (NCDs) and neglected tropical diseases (NTDs) to identify gaps in the design and conduct, as well as strengths, limitations and implications, of this type of research in low- and middle-income countries (LMICs).\ud\udDesign Scoping review of PE studies of complex interventions implemented in LMICs. Six databases were searched focused on studies published since 2008.\ud\udData sources Embase, PubMed, EbscoHost, Web of Science (WOS), Virtual Health Library (VHL) Regional Portal and Global Index Medicus: Regional Indexes AIM (AFRO), LILACS (AMRO/PAHO), IMEMR (EMRO), IMSEAR (SEARO), WPRIM (WPRO) Global Index Regional Indexes, MEDLINE, SciELO.\ud\udEligibility criteria Studies conducted in LMICs on PEs of randomised controlled trials (RCTs) and non-RCTs published between January 2008 and January 2020. Other criteria were studies of interventions for people at risk or having physical and mental NCDs, and/or NTDs, and/or their healthcare providers and/or others related to achieve better health for these two disease groups. Studies were excluded if they were not reported in English or Spanish or Portuguese or French, not peer-reviewed articles, not empirical research and not human research.\ud\udData extraction and synthesis Data extracted to be evaluated were: available evidence in the utilisation of PE in the areas of NCDs and NTDs, including frameworks and theories used; methods applied to conduct PEs; and in a subsample, the barriers and facilitators to implement complex interventions identified through the PE. Variables were extracted and categorised. The information was synthesised through quantitative analysis by reporting frequencies and percentages. Qualitative analysis was also performed to understand facilitators and barriers presented in these studies. The implications for PEs, and how the information from the PE was used by researchers or other stakeholders were also assessed in this approach.\ud\udResults 303 studies were identified, 79% were for NCDs, 12% used the label ‘PE’, 27% described a theory or framework for the PE, and 42% used mixed methods to analyse their findings. Acceptability, barriers and facilitators to implement the interventions, experiences and perceptions, and feasibility were the outcomes most frequently evaluated as part of the PEs. Barriers and facilitators themes identified were contextual factors, health system factors, human resources, attitudes and policy factors.\ud\udConclusions PEs in NCDs and NTDs are used in LMICs with a wide variety of methods. This review identified many PEs that were not labelled by the authors as such, as well as a limited application of PE-related theories and frameworks, and heterogeneous reporting of this type of study.
Published: 2022

17. Process Evaluation of an Implementation Trial: Design, Rationale, and Early Lessons Learnt From an International Cluster Clinical Trial in Intracerebral Hemorrhage

Author: Ouyang, Menglu, primary, Anderson, Craig S., additional, Song, Lili, additional, Malavera, Alejandra, additional, Jan, Stephen, additional, Cheng, Guojuan, additional, Chu, Honglin, additional, Hu, Xin, additional, Ma, Lu, additional, Chen, Xiaoying, additional, You, Chao, additional, and Liu, Hueiming, additional
Published: 2022
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18. The value of process evaluation for public health interventions: field-case studies for non-communicable disease prevention and management in five countries

Author: Lazo-Porras, María, primary, Brandt, Lena R, additional, Cornejo-Vucovich, Elsa, additional, Denman, Catalina A, additional, Diez-Canseco, Francisco, additional, Malavera, Alejandra, additional, Mukherjee, Ankita, additional, Ouyang, Menglu, additional, Praveen, Devarsetty, additional, Schierhout, Gill, additional, Sun, Yuewen, additional, Yin, Xuejun, additional, Zhang, Puhong, additional, and Liu, Hueiming, additional
Published: 2022
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19. TACTICS - Trial of Advanced CT Imaging and Combined Education Support for Drip and Ship: evaluating the effectiveness of an ‘implementation intervention’ in providing better patient access to reperfusion therapies: protocol for a non-randomised controlled stepped wedge cluster trial in acute stroke

Author: Ryan, Annika, primary, Paul, Christine L, additional, Cox, Martine, additional, Whalen, Olivia, additional, Bivard, Andrew, additional, Attia, John, additional, Bladin, Christopher, additional, Davis, Stephen M, additional, Campbell, Bruce C V, additional, Parsons, Mark, additional, Grimley, Rohan S, additional, Anderson, Craig, additional, Donnan, Geoffrey A, additional, Oldmeadow, Christopher, additional, Kuhle, Sarah, additional, Walker, Frederick R, additional, Hood, Rebecca J, additional, Maltby, Steven, additional, Keynes, Angela, additional, Delcourt, Candice, additional, Hatchwell, Luke, additional, Malavera, Alejandra, additional, Yang, Qing, additional, Wong, Andrew, additional, Muller, Claire, additional, Sabet, Arman, additional, Garcia-Esperon, Carlos, additional, Brown, Helen, additional, Spratt, Neil, additional, Kleinig, Timothy, additional, Butcher, Ken, additional, and Levi, Christopher R, additional
Published: 2022
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20. Prognostic significance of early pyrexia in acute intracerebral haemorrhage: The INTERACT2 study

Author: Malavera, Alejandra, You, Shoujiang, Zheng, Danni, Delcourt, Candice, and Anderson, Craig S.
Published: 2021
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21. Twelve-Month Outcomes of the AFFINITY Trial of Fluoxetine for Functional Recovery After Acute Stroke: AFFINITY Trial Steering Committee on Behalf of the AFFINITY Trial Collaboration

Author: Hankey, Graeme J., primary, Hackett, Maree L., additional, Almeida, Osvaldo P., additional, Flicker, Leon, additional, Mead, Gillian E., additional, Dennis, Martin S., additional, Etherton-Beer, Christopher, additional, Ford, Andrew H., additional, Billot, Laurent, additional, Jan, Stephen, additional, Lung, Thomas, additional, Lundström, Erik, additional, Sunnerhagen, Katharina S., additional, Anderson, Craig S., additional, Thang-Nguyen, Huy, additional, Gommans, John, additional, Yi, Qilong, additional, Murray, Veronica, additional, Herbert, Robert, additional, Carter, Gregory, additional, Donnan, Geoffrey A., additional, Nguyen, Huy-Thang, additional, Li, Qiang, additional, Bompoint, Severine, additional, Barrett, Sarah, additional, Claxton, Anne, additional, O’Dea, Julia, additional, Tang, Michelle, additional, Williams, Clare, additional, Peterson, Shenae, additional, Drummond, Christie, additional, Hong, Uyen-Ha, additional, My Le, Linh-Thi, additional, Bich Ngo, Tram-Thi, additional, Mai, Yen-Bao, additional, Han, Huyen-Thanh, additional, Truong, Nhu-Quynh, additional, Nguyen, Huong-Thi, additional, Ngo, Hai-Thanh, additional, Nguyen, Thi Binh, additional, Kieu Ha, Oanh-Thi, additional, Huyen Nguyen, Trang-Le, additional, Lindley, Richard I., additional, New, Peter, additional, Lee, Andrew, additional, Tran, Thanh-Trung, additional, Truc Mai Le, Loan-Tran, additional, Vu Kieu, Thuy-Le, additional, Nguyen, Sang-Van, additional, Diem Nguyen, Thuy-Anh, additional, Dang, Tam-Nhat, additional, Truc Phan, Hanh-Thi, additional, Ngoc Vo, Loan-Thi, additional, Nguyen, Mai-Hue, additional, Dang, Hanh-Cao, additional, Tran, Hong-Thi, additional, Cam Dam, Linh-Thi, additional, Kim Ngo, Trinh-Thi, additional, Thanh Pham, Thai-Nguyen, additional, Pham, Binh-Nguyen, additional, Thanh Dao, Nha-Thi, additional, Bich Nguyen, Huong-Thi, additional, Cam Le, Linh-Thi, additional, Do, Chi-Minh, additional, Huynh, Huy-Quoc, additional, Tran, Giau-Thi Kim, additional, Le, Oanh-Thi, additional, Khanh Tran, Ly-Thi, additional, Duong, Chinh-Dinh, additional, Kieu, Duong-Van, additional, Le, Na, additional, Nguyen, Hoa-Ngoc, additional, Le, Binh-Van, additional, Nguyen, Long-Thanh, additional, Nguyen, Long-Van, additional, Dinh, Tuan-Quoc, additional, Vo, Tan-Van, additional, Bui, Tram-Ngoc, additional, To Hoang, Uyen-Thi, additional, Bich Nguyen, Hien-Thi, additional, Thu Nguyen, Ha-Thi, additional, Lam, Nga-Thuy, additional, Le, Khanh-Kim, additional, Trinh, Phuong-Thanh, additional, Huynh, Hop-Quang, additional, Thu Nguyen, Thao-Thi, additional, Lu, Huyen-Ngoc, additional, Pham, Tham-Hong, additional, Nguyen, Sam-Hoanh, additional, Le, Ninh-Hong, additional, Nguyen, Giang-Truong, additional, Doan, Bich-Thi, additional, Pham, Sung-Phuoc, additional, Luong, Duong-Huu, additional, Mai, Ha-Van, additional, Tran, Thuc-Van, additional, Do, Phuong-Thi, additional, Le, Hoai-Thi, additional, Nguyen, Chi-Van, additional, Nguyen, Phuong-Doan, additional, Mai, Ton-Duy, additional, Dao, Phuong-Viet, additional, Nguyen, Dung-Tien, additional, Khuong, Dai-Quoc, additional, Vuong, Trung-Xuan, additional, Vu, Lan-Tuong, additional, Ngo, Ngoc-Duc, additional, Dang, Hanh-Hong, additional, Truong, Phuong-Thai, additional, Le, Ngan-Thi, additional, Hoang, Hoa-Van, additional, Do, Chung-Quang, additional, Nguyen, Minh-Thao, additional, Dam, Anh-Hai, additional, Le, Quynh-Nhu, additional, Nguyen, Ngoc-Hoang, additional, Nguyen, Tuyen-Van, additional, Le, Toan-Dinh, additional, Hai Dinh, Ha-Thi, additional, Pham, Cuong–Van, additional, Ngoc Thach, Khanh-Thi, additional, Nguyen, Linh-Hai, additional, Nguyen, Loan-Thi, additional, Le, Vien-Chi, additional, Tran, Phuong-Hong, additional, Nguyen, Tai-Anh, additional, Le, Tuan-Van, additional, Truong, Luyen-Van, additional, Bui, Tue-Chau, additional, Huynh, Ngoc-Xuan, additional, Dinh, Lap-Van, additional, Pham, An-Gia, additional, Huyen Le, Trang-Thi, additional, Nguyen, Vy-Tuong, additional, Nguyen, Yen-Hai, additional, Nguyen, Thang-Ba, additional, Thai, Huy, additional, Ngoc Pham, Quyen-Thi, additional, Dao, Khoa-Duy, additional, Bao Pham, Quoc-Nguyen, additional, Huyen Dang, Thuong-Thi, additional, To Dinh, Huong-Huynh, additional, Tong, Trang-Mai, additional, Vu, Thuy-Thi, additional, Le, Si-Tri, additional, Tran, Tai-Ngoc, additional, Tran, Phuong-Hoai, additional, Nhu Dinh, Ngoc-Thuy, additional, Nguyen, Binh-Thanh, additional, Do, Vinh-Phuong, additional, Nguyen, Anh-Ngoc, additional, Thanh Nguyen, Binh-Thi, additional, Blacker, David, additional, Bunce, Lindsey, additional, Tan, Ai Ling, additional, Ghia, Darshan, additional, Edmonds, Gillian, additional, O’Loughlin, Nicole, additional, Ewing, Megan, additional, Whittaker, Kerri-Ann, additional, Deane, Lorralee, additional, Gawarikar, Yash, additional, Jones, Brett, additional, Lopez, Maria, additional, Nagesh, Koushik, additional, Siracusa, Emma, additional, Davis, Stephen, additional, McDonald, Amy, additional, Tsoleridis, Jess, additional, McCoy, Rachael, additional, Jackson, David, additional, Silver, Gab, additional, Bates, Timothy R., additional, Boudville, Amanda, additional, Southwell, Lynda, additional, Cordato, Dennis, additional, McDougall, Alan J., additional, Cappelen-Smith, Cecilia, additional, Calic, Zeljka, additional, Askar, Shabeel, additional, Cheng, Qi, additional, Kumar, Raymond, additional, Geraghty, Richard, additional, Duroux, Maree, additional, Ratcliffe, Megan, additional, Shone, Samantha, additional, McLennan, Cassandra, additional, Sahathevan, Ramesh, additional, Hair, Casey, additional, Levy, Stanley, additional, Macdonald, Beverley, additional, Nham, Benjamin, additional, Rigney, Louise, additional, Nathani, Dev, additional, Gopinath, Sumana, additional, Patel, Vishal, additional, Mamun, Abul, additional, Trewin, Benjamin, additional, Phua, Chun, additional, Choong, Ho, additional, Tarrant, Lauren, additional, Boyle, Kerry, additional, Hewitt, Luisa, additional, Hourn, Monique, additional, Masterson, Amanda, additional, Oakley, Kim, additional, Ruddell, Karen, additional, Sanctuary, Colette, additional, Veitch, Kimberley, additional, Burdusel, Camelia, additional, Lee, Lina, additional, Cheuk, Gary, additional, Christley, Jeremy, additional, Hartwell, Tabitha, additional, Davenport, Craig, additional, Hickey, Kate, additional, Robertson, Rosanna, additional, Carr, Michelle, additional, Akbari, Sam, additional, Coyle, Hannah, additional, O’Neill, Megan, additional, Redpath, Cameron, additional, Roberts, Caroline, additional, Tabesh, Marjan, additional, Withiel, Toni, additional, Abeysuriya, Kapila, additional, Granger, Andrew, additional, Abraham, Angela, additional, Chua, Chermaine, additional, Nguyen, Dung Do, additional, Surendran, Vathani, additional, Daines, Melissa, additional, Shivlal, David, additional, Latif, Mudassar, additional, Mughal, Noreen, additional, Morgan, Patricia, additional, Krause, Martin, additional, Priglinger, Miriam, additional, Shandiz, Ehsan E., additional, Day, Susan, additional, Kho, Lay, additional, Pollack, Michael, additional, Dunne, Judith, additional, Baines, Helen, additional, Rees, Merridie, additional, White, Jenni, additional, Withanage, Aicuratiya, additional, Delcourt, Candice, additional, Carcel, Cheryl, additional, Malavera, Alejandra, additional, Kunchok, Amy, additional, Ray, Elizabeth, additional, Pepper, Elizabeth, additional, Duckett, Emily, additional, Ormond, Sally, additional, Moey, Andrew, additional, Kleinig, Timothy, additional, Maxwell, Vanessa, additional, Baldwin, Chantal, additional, Vallat, Wilson, additional, Field, Deborah, additional, Markus, Romesh, additional, Page, Kirsty, additional, Wheelwright, Danielle, additional, Bolitho, Sam, additional, Faux, Steven, additional, Sangvatanakul, Fix, additional, Brown, Alexis, additional, Walker, Susan, additional, Massey, Jennifer, additional, Hayes, Hillary, additional, Katrak, Pesi, additional, Winker, Annie, additional, Zagami, Alessandro, additional, Bailey, Alanah, additional, Mccormack, Sarah, additional, Murray, Andrew, additional, Rollason, Mark, additional, Taylor, Christopher, additional, O’Rourke, Fintan, additional, Kuang, Ye Min, additional, Burnet, Heike, additional, Liu, Yvonne, additional, Wu, Aileen, additional, Ramirez, Diana, additional, Wijeratne, Tissa, additional, Celestino, Sherisse, additional, Low, Essie, additional, Chen, Cynthia, additional, Bergqvist, Jennifer, additional, Evans, Andrew, additional, Leung, Queenie, additional, Jude, Martin, additional, McQueen, Rachael, additional, Mohr, Katherine, additional, Kernaghan, Latitia, additional, Stockle, Paul, additional, Tan, Boon L., additional, Laubscher, Sara, additional, Schmid, Diana, additional, Spooner, Melissa, additional, Lallu, Bhavesh, additional, Pepperell, Bronwen, additional, Chalissery, John, additional, Mahawish, Karim, additional, DeCaigney, Susan, additional, Broughton, Paula, additional, Knight, Karen, additional, Duque, Veronica, additional, McNaughton, Harry, additional, Lanford, Jeremy, additional, Fu, Vivian, additional, and Wong, Lai-Kin, additional
Published: 2021
Full Text: View/download PDF

22. Thrombolysis outcomes according to arterial characteristics of acute ischemic stroke by alteplase dose and blood pressure target

Author: Zhou, Zien, primary, Xia, Chao, additional, Mair, Grant, additional, Delcourt, Candice, additional, Yoshimura, Sohei, additional, Liu, Xiaosheng, additional, Chen, Zengai, additional, Malavera, Alejandra, additional, Carcel, Cheryl, additional, Chen, Xiaoying, additional, Wang, Xia, additional, Al-Shahi Salman, Rustam, additional, Robinson, Thompson G, additional, Lindley, Richard I, additional, Chalmers, John, additional, Wardlaw, Joanna M, additional, Parsons, Mark W, additional, Demchuk, Andrew M, additional, and Anderson, Craig S, additional
Published: 2021
Full Text: View/download PDF

23. sj-pdf-1-wso-10.1177_17474930211025436 - Supplemental material for Thrombolysis outcomes according to arterial characteristics of acute ischemic stroke by alteplase dose and blood pressure target

Author: Zhou, Zien, Xia, Chao, Mair, Grant, Delcourt, Candice, Yoshimura, Sohei, Liu, Xiaosheng, Chen, Zengai, Malavera, Alejandra, Carcel, Cheryl, Chen, Xiaoying, Wang, Xia, Al-Shahi Salman, Rustam, Robinson, Thompson G, Lindley, Richard I, Chalmers, John, Wardlaw, Joanna M, Parsons, Mark W, Demchuk, Andrew M, and Anderson, Craig S
Subjects: FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract: Supplemental material, sj-pdf-1-wso-10.1177_17474930211025436 for Thrombolysis outcomes according to arterial characteristics of acute ischemic stroke by alteplase dose and blood pressure target by Zien Zhou, Chao Xia, Grant Mair, Candice Delcourt, Sohei Yoshimura, Xiaosheng Liu, Zengai Chen, Alejandra Malavera, Cheryl Carcel, Xiaoying Chen, Xia Wang, Rustam Al-Shahi Salman, Thompson G Robinson, Richard I Lindley, John Chalmers, Joanna M Wardlaw, Mark W Parsons, Andrew M Demchuk and Craig S Anderson in International Journal of Stroke
Published: 2021
Full Text: View/download PDF

24. Twelve-Month Outcomes of the AFFINITY Trial of Fluoxetine for Functional Recovery After Acute Stroke: AFFINITY Trial Steering Committee on Behalf of the AFFINITY Trial Collaboration

Author: Hankey, Graeme J., Hackett, Maree, Almeida, Osvaldo P., Flicker, Leon, Mead, Gillian E., Dennis, Martin S., Etherton-Beer, Christopher, Ford, Andrew H., Billot, Laurent, Jan, Stephen, Lung, Thomas, Lundström, Erik, Sunnerhagen, Katharina S., Anderson, Craig S., Thang-Nguyen, Huy, Gommans, John, Yi, Qilong, Murray, Veronica, Herbert, Robert, Carter, Gregory, Donnan, Geoffrey A., Nguyen, Huy-Thang, Li, Qiang, Bompoint, Severine, Barrett, Sarah, Claxton, Anne, O’Dea, Julia, Tang, Michelle, Williams, Clare, Peterson, Shenae, Drummond, Christie, Hong, Uyen-Ha, My Le, Linh-Thi, Bich Ngo, Tram-Thi, Mai, Yen-Bao, Han, Huyen-Thanh, Truong, Nhu-Quynh, Nguyen, Huong-Thi, Ngo, Hai-Thanh, Nguyen, Thi Binh, Kieu Ha, Oanh-Thi, Huyen Nguyen, Trang-Le, Lindley, Richard I., New, Peter, Lee, Andrew, Tran, Thanh-Trung, Truc Mai Le, Loan-Tran, Vu Kieu, Thuy-Le, Nguyen, Sang-Van, Diem Nguyen, Thuy-Anh, Dang, Tam-Nhat, Truc Phan, Hanh-Thi, Ngoc Vo, Loan-Thi, Nguyen, Mai-Hue, Dang, Hanh-Cao, Tran, Hong-Thi, Cam Dam, Linh-Thi, Kim Ngo, Trinh-Thi, Thanh Pham, Thai-Nguyen, Pham, Binh-Nguyen, Thanh Dao, Nha-Thi, Bich Nguyen, Huong-Thi, Cam Le, Linh-Thi, Do, Chi-Minh, Huynh, Huy-Quoc, Tran, Giau-Thi Kim, Le, Oanh-Thi, Khanh Tran, Ly-Thi, Duong, Chinh-Dinh, Kieu, Duong-Van, Le, Na, Nguyen, Hoa-Ngoc, Le, Binh-Van, Nguyen, Long-Thanh, Nguyen, Long-Van, Dinh, Tuan-Quoc, Vo, Tan-Van, Bui, Tram-Ngoc, To Hoang, Uyen-Thi, Bich Nguyen, Hien-Thi, Thu Nguyen, Ha-Thi, Lam, Nga-Thuy, Le, Khanh-Kim, Trinh, Phuong-Thanh, Huynh, Hop-Quang, Thu Nguyen, Thao-Thi, Lu, Huyen-Ngoc, Pham, Tham-Hong, Nguyen, Sam-Hoanh, Le, Ninh-Hong, Nguyen, Giang-Truong, Doan, Bich-Thi, Pham, Sung-Phuoc, Luong, Duong-Huu, Mai, Ha-Van, Tran, Thuc-Van, Do, Phuong-Thi, Le, Hoai-Thi, Nguyen, Chi-Van, Nguyen, Phuong-Doan, Mai, Ton-Duy, Dao, Phuong-Viet, Nguyen, Dung-Tien, Khuong, Dai-Quoc, Vuong, Trung-Xuan, Vu, Lan-Tuong, Ngo, Ngoc-Duc, Dang, Hanh-Hong, Truong, Phuong-Thai, Le, Ngan-Thi, Hoang, Hoa-Van, Do, Chung-Quang, Nguyen, Minh-Thao, Dam, Anh-Hai, Le, Quynh-Nhu, Nguyen, Ngoc-Hoang, Nguyen, Tuyen-Van, Le, Toan-Dinh, Hai Dinh, Ha-Thi, Pham, Cuong–Van, Ngoc Thach, Khanh-Thi, Nguyen, Linh-Hai, Nguyen, Loan-Thi, Le, Vien-Chi, Tran, Phuong-Hong, Nguyen, Tai-Anh, Le, Tuan-Van, Truong, Luyen-Van, Bui, Tue-Chau, Huynh, Ngoc-Xuan, Dinh, Lap-Van, Pham, An-Gia, Huyen Le, Trang-Thi, Nguyen, Vy-Tuong, Nguyen, Yen-Hai, Nguyen, Thang-Ba, Thai, Huy, Ngoc Pham, Quyen-Thi, Dao, Khoa-Duy, Bao Pham, Quoc-Nguyen, Huyen Dang, Thuong-Thi, To Dinh, Huong-Huynh, Tong, Trang-Mai, Vu, Thuy-Thi, Le, Si-Tri, Tran, Tai-Ngoc, Tran, Phuong-Hoai, Nhu Dinh, Ngoc-Thuy, Nguyen, Binh-Thanh, Do, Vinh-Phuong, Nguyen, Anh-Ngoc, Thanh Nguyen, Binh-Thi, Blacker, David, Bunce, Lindsey, Tan, Ai Ling, Ghia, Darshan, Edmonds, Gillian, O’Loughlin, Nicole, Ewing, Megan, Whittaker, Kerri-Ann, Deane, Lorralee, Gawarikar, Yash, Jones, Brett, Lopez, Maria, Nagesh, Koushik, Siracusa, Emma, Davis, Stephen, McDonald, Amy, Tsoleridis, Jess, McCoy, Rachael, Jackson, David, Silver, Gab, Bates, Timothy R., Boudville, Amanda, Southwell, Lynda, Cordato, Dennis, McDougall, Alan J., Cappelen-Smith, Cecilia, Calic, Zeljka, Askar, Shabeel, Cheng, Qi, Kumar, Raymond, Geraghty, Richard, Duroux, Maree, Ratcliffe, Megan, Shone, Samantha, McLennan, Cassandra, Sahathevan, Ramesh, Hair, Casey, Levy, Stanley, Macdonald, Beverley, Nham, Benjamin, Rigney, Louise, Nathani, Dev, Gopinath, Sumana, Patel, Vishal, Mamun, Abul, Trewin, Benjamin, Phua, Chun, Choong, Ho, Tarrant, Lauren, Boyle, Kerry, Hewitt, Luisa, Hourn, Monique, Masterson, Amanda, Oakley, Kim, Ruddell, Karen, Sanctuary, Colette, Veitch, Kimberley, Burdusel, Camelia, Lee, Lina, Cheuk, Gary, Christley, Jeremy, Hartwell, Tabitha, Davenport, Craig, Hickey, Kate, Robertson, Rosanna, Carr, Michelle, Akbari, Sam, Coyle, Hannah, O’Neill, Megan, Redpath, Cameron, Roberts, Caroline, Tabesh, Marjan, Withiel, Toni, Abeysuriya, Kapila, Granger, Andrew, Abraham, Angela, Chua, Chermaine, Nguyen, Dung Do, Surendran, Vathani, Daines, Melissa, Shivlal, David, Latif, Mudassar, Mughal, Noreen, Morgan, Patricia, Krause, Martin, Priglinger, Miriam, Shandiz, Ehsan E., Day, Susan, Kho, Lay, Pollack, Michael, Dunne, Judith, Baines, Helen, Rees, Merridie, White, Jenni, Withanage, Aicuratiya, Delcourt, Candice, Carcel, Cheryl, Malavera, Alejandra, Kunchok, Amy, Ray, Elizabeth, Pepper, Elizabeth, Duckett, Emily, Ormond, Sally, Moey, Andrew, Kleinig, Timothy, Maxwell, Vanessa, Baldwin, Chantal, Vallat, Wilson, Field, Deborah, Markus, Romesh, Page, Kirsty, Wheelwright, Danielle, Bolitho, Sam, Faux, Steven, Sangvatanakul, Fix, Brown, Alexis, Walker, Susan, Massey, Jennifer, Hayes, Hillary, Katrak, Pesi, Winker, Annie, Zagami, Alessandro, Bailey, Alanah, Mccormack, Sarah, Murray, Andrew, Rollason, Mark, Taylor, Christopher, O’Rourke, Fintan, Kuang, Ye Min, Burnet, Heike, Liu, Yvonne, Wu, Aileen, Ramirez, Diana, Wijeratne, Tissa, Celestino, Sherisse, Low, Essie, Chen, Cynthia, Bergqvist, Jennifer, Evans, Andrew, Leung, Queenie, Jude, Martin, McQueen, Rachael, Mohr, Katherine, Kernaghan, Latitia, Stockle, Paul, Tan, Boon L., Laubscher, Sara, Schmid, Diana, Spooner, Melissa, Lallu, Bhavesh, Pepperell, Bronwen, Chalissery, John, Mahawish, Karim, DeCaigney, Susan, Broughton, Paula, Knight, Karen, Duque, Veronica, McNaughton, Harry, Lanford, Jeremy, Fu, Vivian, Wong, Lai-Kin, Hankey, Graeme J., Hackett, Maree, Almeida, Osvaldo P., Flicker, Leon, Mead, Gillian E., Dennis, Martin S., Etherton-Beer, Christopher, Ford, Andrew H., Billot, Laurent, Jan, Stephen, Lung, Thomas, Lundström, Erik, Sunnerhagen, Katharina S., Anderson, Craig S., Thang-Nguyen, Huy, Gommans, John, Yi, Qilong, Murray, Veronica, Herbert, Robert, Carter, Gregory, Donnan, Geoffrey A., Nguyen, Huy-Thang, Li, Qiang, Bompoint, Severine, Barrett, Sarah, Claxton, Anne, O’Dea, Julia, Tang, Michelle, Williams, Clare, Peterson, Shenae, Drummond, Christie, Hong, Uyen-Ha, My Le, Linh-Thi, Bich Ngo, Tram-Thi, Mai, Yen-Bao, Han, Huyen-Thanh, Truong, Nhu-Quynh, Nguyen, Huong-Thi, Ngo, Hai-Thanh, Nguyen, Thi Binh, Kieu Ha, Oanh-Thi, Huyen Nguyen, Trang-Le, Lindley, Richard I., New, Peter, Lee, Andrew, Tran, Thanh-Trung, Truc Mai Le, Loan-Tran, Vu Kieu, Thuy-Le, Nguyen, Sang-Van, Diem Nguyen, Thuy-Anh, Dang, Tam-Nhat, Truc Phan, Hanh-Thi, Ngoc Vo, Loan-Thi, Nguyen, Mai-Hue, Dang, Hanh-Cao, Tran, Hong-Thi, Cam Dam, Linh-Thi, Kim Ngo, Trinh-Thi, Thanh Pham, Thai-Nguyen, Pham, Binh-Nguyen, Thanh Dao, Nha-Thi, Bich Nguyen, Huong-Thi, Cam Le, Linh-Thi, Do, Chi-Minh, Huynh, Huy-Quoc, Tran, Giau-Thi Kim, Le, Oanh-Thi, Khanh Tran, Ly-Thi, Duong, Chinh-Dinh, Kieu, Duong-Van, Le, Na, Nguyen, Hoa-Ngoc, Le, Binh-Van, Nguyen, Long-Thanh, Nguyen, Long-Van, Dinh, Tuan-Quoc, Vo, Tan-Van, Bui, Tram-Ngoc, To Hoang, Uyen-Thi, Bich Nguyen, Hien-Thi, Thu Nguyen, Ha-Thi, Lam, Nga-Thuy, Le, Khanh-Kim, Trinh, Phuong-Thanh, Huynh, Hop-Quang, Thu Nguyen, Thao-Thi, Lu, Huyen-Ngoc, Pham, Tham-Hong, Nguyen, Sam-Hoanh, Le, Ninh-Hong, Nguyen, Giang-Truong, Doan, Bich-Thi, Pham, Sung-Phuoc, Luong, Duong-Huu, Mai, Ha-Van, Tran, Thuc-Van, Do, Phuong-Thi, Le, Hoai-Thi, Nguyen, Chi-Van, Nguyen, Phuong-Doan, Mai, Ton-Duy, Dao, Phuong-Viet, Nguyen, Dung-Tien, Khuong, Dai-Quoc, Vuong, Trung-Xuan, Vu, Lan-Tuong, Ngo, Ngoc-Duc, Dang, Hanh-Hong, Truong, Phuong-Thai, Le, Ngan-Thi, Hoang, Hoa-Van, Do, Chung-Quang, Nguyen, Minh-Thao, Dam, Anh-Hai, Le, Quynh-Nhu, Nguyen, Ngoc-Hoang, Nguyen, Tuyen-Van, Le, Toan-Dinh, Hai Dinh, Ha-Thi, Pham, Cuong–Van, Ngoc Thach, Khanh-Thi, Nguyen, Linh-Hai, Nguyen, Loan-Thi, Le, Vien-Chi, Tran, Phuong-Hong, Nguyen, Tai-Anh, Le, Tuan-Van, Truong, Luyen-Van, Bui, Tue-Chau, Huynh, Ngoc-Xuan, Dinh, Lap-Van, Pham, An-Gia, Huyen Le, Trang-Thi, Nguyen, Vy-Tuong, Nguyen, Yen-Hai, Nguyen, Thang-Ba, Thai, Huy, Ngoc Pham, Quyen-Thi, Dao, Khoa-Duy, Bao Pham, Quoc-Nguyen, Huyen Dang, Thuong-Thi, To Dinh, Huong-Huynh, Tong, Trang-Mai, Vu, Thuy-Thi, Le, Si-Tri, Tran, Tai-Ngoc, Tran, Phuong-Hoai, Nhu Dinh, Ngoc-Thuy, Nguyen, Binh-Thanh, Do, Vinh-Phuong, Nguyen, Anh-Ngoc, Thanh Nguyen, Binh-Thi, Blacker, David, Bunce, Lindsey, Tan, Ai Ling, Ghia, Darshan, Edmonds, Gillian, O’Loughlin, Nicole, Ewing, Megan, Whittaker, Kerri-Ann, Deane, Lorralee, Gawarikar, Yash, Jones, Brett, Lopez, Maria, Nagesh, Koushik, Siracusa, Emma, Davis, Stephen, McDonald, Amy, Tsoleridis, Jess, McCoy, Rachael, Jackson, David, Silver, Gab, Bates, Timothy R., Boudville, Amanda, Southwell, Lynda, Cordato, Dennis, McDougall, Alan J., Cappelen-Smith, Cecilia, Calic, Zeljka, Askar, Shabeel, Cheng, Qi, Kumar, Raymond, Geraghty, Richard, Duroux, Maree, Ratcliffe, Megan, Shone, Samantha, McLennan, Cassandra, Sahathevan, Ramesh, Hair, Casey, Levy, Stanley, Macdonald, Beverley, Nham, Benjamin, Rigney, Louise, Nathani, Dev, Gopinath, Sumana, Patel, Vishal, Mamun, Abul, Trewin, Benjamin, Phua, Chun, Choong, Ho, Tarrant, Lauren, Boyle, Kerry, Hewitt, Luisa, Hourn, Monique, Masterson, Amanda, Oakley, Kim, Ruddell, Karen, Sanctuary, Colette, Veitch, Kimberley, Burdusel, Camelia, Lee, Lina, Cheuk, Gary, Christley, Jeremy, Hartwell, Tabitha, Davenport, Craig, Hickey, Kate, Robertson, Rosanna, Carr, Michelle, Akbari, Sam, Coyle, Hannah, O’Neill, Megan, Redpath, Cameron, Roberts, Caroline, Tabesh, Marjan, Withiel, Toni, Abeysuriya, Kapila, Granger, Andrew, Abraham, Angela, Chua, Chermaine, Nguyen, Dung Do, Surendran, Vathani, Daines, Melissa, Shivlal, David, Latif, Mudassar, Mughal, Noreen, Morgan, Patricia, Krause, Martin, Priglinger, Miriam, Shandiz, Ehsan E., Day, Susan, Kho, Lay, Pollack, Michael, Dunne, Judith, Baines, Helen, Rees, Merridie, White, Jenni, Withanage, Aicuratiya, Delcourt, Candice, Carcel, Cheryl, Malavera, Alejandra, Kunchok, Amy, Ray, Elizabeth, Pepper, Elizabeth, Duckett, Emily, Ormond, Sally, Moey, Andrew, Kleinig, Timothy, Maxwell, Vanessa, Baldwin, Chantal, Vallat, Wilson, Field, Deborah, Markus, Romesh, Page, Kirsty, Wheelwright, Danielle, Bolitho, Sam, Faux, Steven, Sangvatanakul, Fix, Brown, Alexis, Walker, Susan, Massey, Jennifer, Hayes, Hillary, Katrak, Pesi, Winker, Annie, Zagami, Alessandro, Bailey, Alanah, Mccormack, Sarah, Murray, Andrew, Rollason, Mark, Taylor, Christopher, O’Rourke, Fintan, Kuang, Ye Min, Burnet, Heike, Liu, Yvonne, Wu, Aileen, Ramirez, Diana, Wijeratne, Tissa, Celestino, Sherisse, Low, Essie, Chen, Cynthia, Bergqvist, Jennifer, Evans, Andrew, Leung, Queenie, Jude, Martin, McQueen, Rachael, Mohr, Katherine, Kernaghan, Latitia, Stockle, Paul, Tan, Boon L., Laubscher, Sara, Schmid, Diana, Spooner, Melissa, Lallu, Bhavesh, Pepperell, Bronwen, Chalissery, John, Mahawish, Karim, DeCaigney, Susan, Broughton, Paula, Knight, Karen, Duque, Veronica, McNaughton, Harry, Lanford, Jeremy, Fu, Vivian, and Wong, Lai-Kin
Abstract: Background and Purpose: The AFFINITY trial (Assessment of Fluoxetine in Stroke Recovery) reported that oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and seizures. After trial medication was ceased at 6 months, survivors were followed to 12 months post-randomization. This preplanned secondary analysis aimed to determine any sustained or delayed effects of fluoxetine at 12 months post-randomization. Methods: AFFINITY was a randomized, parallel-group, double-blind, placebo-controlled trial in adults (n=1280) with a clinical diagnosis of stroke in the previous 2 to 15 days and persisting neurological deficit who were recruited at 43 hospital stroke units in Australia (n=29), New Zealand (4), and Vietnam (10) between 2013 and 2019. Participants were randomized to oral fluoxetine 20 mg once daily (n=642) or matching placebo (n=638) for 6 months and followed until 12 months after randomization. The primary outcome was function, measured by the modified Rankin Scale, at 6 months. Secondary outcomes for these analyses included measures of the modified Rankin Scale, mood, cognition, overall health status, fatigue, health-related quality of life, and safety at 12 months. Results: Adherence to trial medication was for a mean 167 (SD 48) days and similar between randomized groups. At 12 months, the distribution of modified Rankin Scale categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio, 0.93 [95% CI, 0.76–1.14]; P =0.46). Compared with placebo, patients allocated fluoxetine had fewer recurrent ischemic strokes (14 [2.18%] versus 29 [4.55%]; P =0.02), and no longer had significantly more falls (27 [4.21%] versus 15 [2.35%]; P =0.08), bone fractures (23 [3.58%] versus 11 [1.72%]; P =0.05), or seizures (11 [1.71%] versus 8 [1.25%]; P =0.64) at 12 months. Conclusions: Fluoxetine 20 mg daily for 6 months after acute stroke had no delayed or sustained
Published: 2021

25. Low-Dose vs Standard-Dose Alteplase in Acute Lacunar Ischemic Stroke

Author: Zhou, Zien, Delcourt, Candice, Xia, Chao, Yoshimura, Sohei, Carcel, Cheryl, Torii-Yoshimura, Takako, You, Shoujiang, Malavera, Alejandra, Chen, Xiaoying, Hackett, Maree, Woodward, Mark, Chalmers, John, Xu, Jianrong, Robinson, Thompson G., Parsons, Mark W., Demchuk, Andrew M., Lindley, Richard I., Mair, Grant, Wardlaw, Joanna M., Anderson, Craig S., Zhou, Zien, Delcourt, Candice, Xia, Chao, Yoshimura, Sohei, Carcel, Cheryl, Torii-Yoshimura, Takako, You, Shoujiang, Malavera, Alejandra, Chen, Xiaoying, Hackett, Maree, Woodward, Mark, Chalmers, John, Xu, Jianrong, Robinson, Thompson G., Parsons, Mark W., Demchuk, Andrew M., Lindley, Richard I., Mair, Grant, Wardlaw, Joanna M., and Anderson, Craig S.
Abstract: ObjectiveTo determine any differential efficacy and safety of low- vs standard-dose IV alteplase for lacunar vs nonlacunar acute ischemic stroke (AIS), we performed post hoc analyzes from the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) alteplase dose arm.MethodsIn a cohort of 3,297 ENCHANTED participants, we identified those with lacunar or nonlacunar AIS with different levels of confidence (definite/according to prespecified definitions based on clinical and adjudicated imaging findings. Logistic regression models were used to determine associations of lacunar AIS with 90-day outcomes (primary, modified Rankin Scale [mRS] scores 2–6; secondary, other mRS scores, intracerebral hemorrhage [ICH], and early neurologic deterioration or death) and treatment effects of low- vs standard-dose alteplase across lacunar and nonlacunar AIS with adjustment for baseline covariables.ResultsOf 2,588 participants with available imaging and clinical data, we classified cases as definite/probable lacunar (n = 490) or nonlacunar AIS (n = 2,098) for primary analyses. Regardless of alteplase dose received, lacunar AIS participants had favorable functional (mRS 2–6, adjusted odds ratio [95% confidence interval] 0.60 [0.47–0.77]) and other clinical or safety outcomes compared to participants with nonlacunar AIS. Low-dose alteplase (versus standard) had no differential effect on functional outcomes (mRS 2–6, 1.04 [0.87–1.24]) but reduced the risk of symptomatic ICH in all included participants. There were no differential treatment effects of low- vs standard-dose alteplase on all outcomes across lacunar and nonlacunar AIS (all pinteraction ≥0.07).ConclusionsWe found no evidence from the ENCHANTED trial that low-dose alteplase had any advantages over standard dose for definite/probable lacunar AIS.Classification of EvidenceThis study provides Class II evidence that for patients with lacunar AIS, low-dose alteplase had no additional benefit or safety over standa
Published: 2021

26. Thrombolysis outcomes according to arterial characteristics of acute ischemic stroke by alteplase dose and blood pressure target.

Author: Zhou, Zien, Xia, Chao, Mair, Grant, Delcourt, Candice, Yoshimura, Sohei, Liu, Xiaosheng, Chen, Zengai, Malavera, Alejandra, Carcel, Cheryl, Chen, Xiaoying, Wang, Xia, Al-Shahi Salman, Rustam, Robinson, Thompson G, Lindley, Richard I, Chalmers, John, Wardlaw, Joanna M, Parsons, Mark W, Demchuk, Andrew M, and Anderson, Craig S
Subjects: ISCHEMIC stroke, BLOOD pressure, MAGNETIC resonance angiography, ALTEPLASE, MAGNETIC resonance imaging
Abstract: Background: We explored the influence of low-dose intravenous alteplase and intensive blood pressure lowering on outcomes of acute ischemic stroke according to status/location of vascular obstruction in participants of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED). Methods: ENCHANTED was a multicenter, quasi-factorial, randomized trial to determine efficacy and safety of low- versus standard-dose intravenous alteplase and intensive- versus guideline-recommended blood pressure lowering in acute ischemic stroke patients. In those who had baseline computed tomography or magnetic resonance imaging angiography, the degree of vascular occlusion was grouped according to being no (NVO), medium (MVO), or large (LVO). Logistic regression models were used to determine 90-day outcomes (modified Rankin scale [mRS] shift [primary], other mRS cut-scores, intracranial hemorrhage, early neurologic deterioration, and recanalization) by vascular obstruction status/site. Heterogeneity in associations for outcomes across subgroups was estimated by adding an interaction term to the models. Results: There were 940 participants: 607 in alteplase arm only, 243 in blood pressure arm only, and 90 assigned to both arms. Compared to the NVO group, functional outcome was worse in LVO (mRS shift, adjusted OR [95% CI] 2.13 [1.56–2.90]) but comparable in MVO (1.34 [0.96–1.88]) groups. There were no differences in associations of alteplase dose or blood pressure lowering and outcomes across NVO/MVO/LVO groups (mRS shift: low versus standard alteplase dose 0.84 [0.54–1.30]/0.48 [0.25–0.91]/0.99 [0.75–2.09], Pinteraction = 0.28; intensive versus standard blood pressure lowering 1.32 [0.74–2.38]/0.78 [0.31–1.94]/1.24 [0.64–2.41], Pinteraction = 0.41), except for a borderline significant difference for intensive blood pressure lowering and increased early neurologic deterioration (0.63 [0.14–2.72]/0.17 [0.02–1.47]/2.69 [0.90–8.04], Pinteraction = 0.05). Conclusions: Functional outcome by dose of alteplase or intensity of blood pressure lowering is not modified by vascular obstruction status/site according to analyses from ENCHANTED, although these results are compromised by low statistical power. Clinical Trial Registration: http://www.clinicaltrials.gov. Unique identifiers: NCT01422616 [ABSTRACT FROM AUTHOR]
Published: 2022
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27. Abstract MP3: Low Dose versus Standard Dose Alteplase in Acute Lacunar Ischemic Stroke

Author: Zhou, Zien, primary, Delcourt, Candice, additional, Xia, Chao, additional, Yoshimura, Sohei, additional, Carcel, Cheryl, additional, Torii-Yoshimura, Takako, additional, you, shoujiang, additional, Malavera, Alejandra, additional, Chen, Xiaoying, additional, Hackett, Maree, additional, Woodward, Mark, additional, Chalmers, John, additional, Xu, Jianrong, additional, Robinson, Thompson G, additional, Parsons, Mark W, additional, Demchuk, Andrew M, additional, Lindley, Richard I, additional, Mair, Grant, additional, Wardlaw, Joanna M, additional, and Anderson, Craig S, additional
Published: 2021
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28. Brain Imaging Signs and Health-Related Quality of Life after Acute Ischemic Stroke: Analysis of ENCHANTED Alteplase Dose Arm.

Author: Chen, Xiaoying, Delcourt, Candice, Sun, Lingli, Zhou, Zien, Yoshimura, Sohei, You, Shoujiang, Malavera, Alejandra, Torii-Yoshimura, Takako, Carcel, Cheryl, Arima, Hisatomi, Hackett, Maree, Robinson, Thompson, Song, Lili, Wang, Xia, Lindley, Richard I, Chalmers, John, Anderson, Craig S, Chen, Xiaoying, Delcourt, Candice, Sun, Lingli, Zhou, Zien, Yoshimura, Sohei, You, Shoujiang, Malavera, Alejandra, Torii-Yoshimura, Takako, Carcel, Cheryl, Arima, Hisatomi, Hackett, Maree, Robinson, Thompson, Song, Lili, Wang, Xia, Lindley, Richard I, Chalmers, John, and Anderson, Craig S
Abstract: The influence of specific brain lesions on health-related quality of life (HRQoL) after acute ischemic stroke (AIS) is uncertain. We aimed to identify imaging predictors of poor HRQoL in alteplase-treated participants of the alteplase dose arm of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED). ENCHANTED was an international trial of low- versus standard-dose intravenous alteplase in AIS patients, with functional outcome (modified Rankin scale [mRS]) and HRQoL on the 5-dimension European Quality of Life Scale (EQ-5D) assessed at 90 days post-randomization. Brain images were analyzed centrally by trained assessors. Multivariable logistic regression was undertaken in the study population randomly divided (2:1) into training (development) and validation (performance) groups, with age (per 10-year increase), ethnicity, baseline National Institutes of Health Stroke Scale (NIHSS) score, diabetes mellitus, premorbid function (mRS score 0 or 1), and proxy respondent, forced into all models. Data are presented with odds ratios (ORs) and 95% confidence intervals (CIs). Eight prediction models were developed and validated in 2,526 AIS patients (median age 67.5 years; 38.4% female; 61.7% Asian) with complete brain imaging and 90-day EQ-5D utility score data. The best performance model included acute ischemic changes in the right (OR 1.69, 95% CI: 1.24-2.29) and deep (OR 1.50, 95% CI: 1.03-2.19) middle cerebral artery (MCA) regions. Several background features of brain frailty - atrophy, white matter change, and old infarcts - were significantly associated with adverse physical but not emotional HRQoL domains. In thrombolysed AIS patients, right-sided and deep ischemia within the MCA territory predict poor overall HRQoL, whilst features of old cerebral ischemia are associated with reduced physical HRQoL. [Abstract copyright: © 2020 S. Karger AG, Basel.]
Published: 2020

29. Low-Dose vs Standard-Dose Alteplase in Acute Lacunar Ischemic Stroke

Author: Zhou, Zien, primary, Delcourt, Candice, additional, Xia, Chao, additional, Yoshimura, Sohei, additional, Carcel, Cheryl, additional, Torii-Yoshimura, Takako, additional, You, Shoujiang, additional, Malavera, Alejandra, additional, Chen, Xiaoying, additional, Hackett, Maree L., additional, Woodward, Mark, additional, Chalmers, John, additional, Xu, Jianrong, additional, Robinson, Thompson G., additional, Parsons, Mark W., additional, Demchuk, Andrew M., additional, Lindley, Richard I., additional, Mair, Grant, additional, Wardlaw, Joanna M., additional, and Anderson, Craig S., additional
Published: 2021
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30. Intensive versus guideline‐recommended blood pressure reduction in acute lacunar stroke with intravenous thrombolysis therapy: The ENCHANTED trial

Author: Zhou, Zien, primary, Xia, Chao, additional, Carcel, Cheryl, additional, Yoshimura, Sohei, additional, Wang, Xia, additional, Delcourt, Candice, additional, Malavera, Alejandra, additional, Chen, Xiaoying, additional, Mair, Grant, additional, Woodward, Mark, additional, Chalmers, John, additional, Demchuk, Andrew M., additional, Lindley, Richard I., additional, Robinson, Thompson G., additional, Parsons, Mark W., additional, Wardlaw, Joanna M., additional, and Anderson, Craig S., additional
Published: 2020
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31. Screening for Fabry Disease in Young Strokes in the Australian Stroke Clinical Registry (AuSCR)

Author: Malavera, Alejandra, primary, Cadilhac, Dominique A., additional, Thijs, Vincent, additional, Lim, Joyce Y., additional, Grabsch, Brenda, additional, Breen, Sibilah, additional, Jan, Stephen, additional, and Anderson, Craig S., additional
Published: 2020
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32. Brain imaging abnormalities and outcome after acute ischaemic stroke: the ENCHANTED trial

Author: Delcourt, Candice, primary, Wang, Xia, additional, Zhou, Zien, additional, Wardlaw, Joanna M, additional, Mair, Grant, additional, Robinson, Thompson G, additional, Chen, Xiaoying, additional, Yoshimura, Sohei, additional, Torii-Yoshimura, Takako, additional, Carcel, Cheryl, additional, Calic, Zeljka, additional, Tan, Wee Yong, additional, Malavera, Alejandra, additional, Anderson, Craig S, additional, and Lindley, Richard I, additional
Published: 2020
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33. Clinical prognosis of FLAIR hyperintense arteries in ischaemic stroke patients: a systematic review and meta-analysis

Author: Zhou, Zien, primary, Malavera, Alejandra, additional, Yoshimura, Sohei, additional, Delcourt, Candice, additional, Mair, Grant, additional, Al-Shahi Salman, Rustam, additional, Demchuk, Andrew M, additional, Wardlaw, Joanna M, additional, Lindley, Richard I, additional, and Anderson, Craig S, additional
Published: 2020
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34. Reader reliability and accuracy of brain imaging interpretation in the ENCHANTED trial: Effectiveness of specialist training for non-expert readers

Author: Mair, Grant, Zien Zhou, Yoshimura, Sohei, Shoujiang You, Wee Yong Tan, Carcel, Cheryl, Torii-Yoshimura, Takako, Malavera, Alejandra, Zelika Calic, Delcourt, Candice, Yukai, Liu, Wang, Xia, Xiaoying Chen, Thompson Robinson, Wardlaw, Joanna, Anderson, Craig, and Lindley, Richard I
Published: 2019
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35. Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial

Author: Anderson, Craig S, primary, Huang, Yining, additional, Lindley, Richard I, additional, Chen, Xiaoying, additional, Arima, Hisatomi, additional, Chen, Guofang, additional, Li, Qiang, additional, Billot, Laurent, additional, Delcourt, Candice, additional, Bath, Philip M, additional, Broderick, Joseph P, additional, Demchuk, Andrew M, additional, Donnan, Geoffrey A, additional, Durham, Alice C, additional, Lavados, Pablo M, additional, Lee, Tsong-Hai, additional, Levi, Christopher, additional, Martins, Sheila O, additional, Olavarria, Veronica V, additional, Pandian, Jeyaraj D, additional, Parsons, Mark W, additional, Pontes-Neto, Octavio M, additional, Ricci, Stefano, additional, Sato, Shoichiro, additional, Sharma, Vijay K, additional, Silva, Federico, additional, Song, Lili, additional, Thang, Nguyen H, additional, Wardlaw, Joanna M, additional, Wang, Ji-Guang, additional, Wang, Xia, additional, Woodward, Mark, additional, Chalmers, John, additional, Robinson, Thompson G, additional, Anderson, Craig S., additional, Lindley, Richard I., additional, Bath, Philip M., additional, Broderick, Joseph P., additional, Demchuk, Andrew M., additional, Donnan, Geoffrey A., additional, Durham, Alice C., additional, Lavados, Pablo M., additional, Martins, Sheila O., additional, Olavarria, Veronica V., additional, Pandian, Jeyaraj D., additional, Parsons, Mark W., additional, Pontes-Neto, Octavio M., additional, Sharma, Vijay K., additional, Thang, Nguyen H., additional, Wardlaw, Joanna M., additional, Robinson, Thompson G., additional, Kim, Jong S., additional, Stapf, Christian, additional, Simes, R. John, additional, Hankey, Graeme J., additional, Sandercock, Peter, additional, Bousser, Marie-Germaine, additional, Wong, K.S. Lawrence, additional, Scaria, Anish, additional, Hirakawa, Yoichiro, additional, Moullaali, Tom J., additional, Carcel, Cheryl, additional, Gordon, Penny, additional, Fuentes-Patarroyo, Sully X., additional, Benito, Dino, additional, Chen, Ruiqi, additional, Cao, Yongjun, additional, Kunchok, Amy, additional, Winters, Stephen, additional, Coutts, Shelagh, additional, Yoshimura, Sohei, additional, You, Shoujiang, additional, Yang, Jie, additional, Wu, Guojun, additional, Zhang, Shihong, additional, Manning, Lisa, additional, Mistri, Amit, additional, Haunton, Victoria, additional, Minhas, Jatinder, additional, Malavera, Alejandra, additional, Lim, Joyce, additional, Liu, Leibo, additional, Kumar, Namrata N., additional, Tay, Nicole, additional, Jenson, Kerry, additional, Richtering, Sarah, additional, Tucker, Sharon, additional, Knight, Elizabeth, additional, Ivanova, Elizaveta, additional, Thembani, Emma, additional, Odgers, Elizabeth, additional, Sanders, Elizabeth, additional, Small, Sabrina, additional, Vaghasiya, Ruchita, additional, Armenis, Manuela, additional, Donnelly, Paul, additional, Baig, Merza A., additional, Blacklock, Nick, additional, Naidu, Bala, additional, Monaghan, Helen, additional, Smith, Phillipa, additional, Glass, Parisa, additional, Bai, Xuejie, additional, Li, Qiancheng, additional, Zhu, Pingping, additional, Kong, Liang, additional, He, Ruihong, additional, Zhao, He, additional, Lv, Jiajie, additional, Jia, Haijing, additional, Xi, Zhen, additional, Cong, Yuhan, additional, Cui, Buliang, additional, Deng, Hua, additional, Guo, Ying, additional, He, Lingyu, additional, Jia, Ruolan, additional, Li, Nan, additional, Li, Wei, additional, Liu, Mengxiao, additional, Zhang, Meng, additional, Xu, Ziwei, additional, Zhang, Ting, additional, Zhao, Yan, additional, Gregory, Philip, additional, In, Yunjeong, additional, Kim, Su J., additional, Ahn, Jung E., additional, Kim, Sul H., additional, Hong, Young L., additional, González-McCawley, Francisca, additional, Martins, Magda C.O., additional, Portales, Bernardita, additional, Wang, Ching-Yi, additional, Ryu, Shan-Jen, additional, Aujla, Hardeep, additional, Lewin, Sue, additional, Kumar, Tracy, additional, Barrows, Sara, additional, Ebraimo, Ahtasam, additional, Uyen, Hong H., additional, Giang, Nguyen A., additional, Linh, Le T.M., additional, An, Le T.T., additional, Phuong, Do M., additional, Ngoc, Pham V.B., additional, Hang, Nguyen M., additional, Tran, Nguyen T.B., additional, Hien, Ha T.T., additional, Yen, Mai B., additional, Tram, Ngo T.B., additional, Truc, Tran T.T., additional, Hoa, Nguyen A., additional, Thuan, Nguyen T.B., additional, Oanh, Ha T.K., additional, Arora, Deepti, additional, Verma, Shweta J., additional, Krause, M., additional, Priglinger, M., additional, Day, S., additional, Jala, S., additional, Davies, L., additional, Ray, E., additional, Celestino, S., additional, Law, L.Y., additional, Wijeratne, T., additional, Ng, G., additional, Nagao, K., additional, Weiss, G., additional, Titton, N., additional, Batista, C., additional, Zãn, D., additional, Carbonera, L., additional, Ferreira, K., additional, Castro, R., additional, Martins Filho, R.K., additional, Carvalho, M., additional, Libardi, M., additional, Martins, G., additional, Fagundes, D., additional, Baron, G., additional, Boehringer, A., additional, Barbosa, J., additional, Bazan, R., additional, Braga, G., additional, Luvizutto, G., additional, Ribeiro, P., additional, Winckler, F., additional, Moro, C., additional, Longo, A., additional, Liberato, R., additional, Barbosa, R., additional, Magalhães, P., additional, Portal, M., additional, Martin, K., additional, Souza, A., additional, Cuervo, D., additional, Perin, D., additional, Marques, L., additional, Oliveira, F., additional, Battaglini, M., additional, Lourenço, F., additional, Silva, G., additional, Duarte, L., additional, Alves, M., additional, Sousa, J., additional, Uhehara, M., additional, Brunser, A., additional, Mazzón, E., additional, Spencer, M., additional, Acosta, I., additional, Rojo, A., additional, Rivas, R., additional, Klapp, C., additional, Carvallo, L., additional, Carvallo, P., additional, Mansilla, E., additional, Flores, J., additional, Alvarado, M., additional, Herrera, A., additional, Reyes, C., additional, Jurado, F., additional, Bustamante, G., additional, Bravo, L., additional, Matamala, J.M., additional, Guerrero, R., additional, Zhou, S., additional, Ping, L., additional, Liu, W., additional, Liu, L., additional, Tian, Y., additional, Xu, H., additional, Wang, J., additional, Wang, L., additional, Zhen, Z., additional, Zhang, J., additional, Yan, M., additional, Zhang, Q., additional, Tao, X., additional, Liu, C., additional, Shi, J., additional, Zhang, X., additional, Tai, L., additional, Xu, L., additional, Lu, H., additional, Nie, H., additional, Li, X., additional, Zhou, J., additional, Liu, Y., additional, Gong, P., additional, Zhao, H., additional, Li, 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additional, Wei, C., additional, He, J., additional, Wang, B., additional, Li, W, additional, Chen, P, additional, Guo, F, additional, Dai, H, additional, Dai, M, additional, Zeng, X., additional, Chen, B., additional, Long, F., additional, Su, Q., additional, Bao, B., additional, Wu, T., additional, Wu, X., additional, Shao, Y., additional, Li, S., additional, Xu, Y., additional, Castellanos, J.A., additional, Muñoz-Collazos, M., additional, Solano, E., additional, Leung, W.H.T., additional, Sureshbabu, S., additional, Sharma, S.N., additional, George, S., additional, Shekhar, S., additional, Singla, S., additional, Saini, L., additional, Sunita, -, additional, Kate, M., additional, Sarvotham, R., additional, William, A.G., additional, Deepak, A., additional, BK, M., additional, Benny, R., additional, Bolegave, V., additional, Basle, M., additional, Gore, S., additional, George, P., additional, Kumaravelu, S., additional, Rahamath, S., additional, Raj, P.G., additional, Devi, A.R., additional, Sharma, A., additional, Prajapati, J., additional, Parmar, M., additional, Patel, D., additional, Panchal, T., additional, Gorthi, S.P., additional, Prabhu, V., additional, Prabhu, A., additional, Chandran, V., additional, Chatterjee, A., additional, Nair, R., additional, Nambiar, V.K., additional, TS, D., additional, TP, S., additional, Ajai, V., additional, Paul, S., additional, Natarajan, P.C., additional, Chittibabu, D., additional, Borah, N.C., additional, Ghose, M., additional, Choudhury, N., additional, Gohain, P., additional, Kalita, K., additional, Duberkar, D., additional, Pawar, N., additional, Bhaviskar, R., additional, Caterbi, E., additional, Cenciarelli, S., additional, Condurso, R., additional, Gallinella, E., additional, Greco, L., additional, Marando, C., additional, Mastrocola, S., additional, Mattioni, A., additional, Sacchini, E., additional, Sicilia, I., additional, Gallina, A., additional, Giannandrea, D., additional, Marsili, E., additional, Mazzoli, T., additional, Padiglioni, C., additional, Corea, F., additional, Guidubaldi, A., additional, Micheli, S., additional, Barbi, M., additional, Kim, J., additional, Song, H.J., additional, Jeong, H.S., additional, Lim, J.G., additional, Park, S.M., additional, Lee, K.B., additional, Hwang, H.W., additional, Kwon, S.U., additional, Kang, D.W., additional, Kim, Y.J., additional, Kim, B.J., additional, Park, J.M., additional, Kang, K., additional, Kim, B., additional, Kwon, O., additional, Kim, Y.W., additional, Lee, J.J., additional, Hwang, Y.H., additional, Kwon, H.S., additional, Koo, J., additional, Lee, K., additional, Kim, T., additional, Ahn, A., additional, Rha, J.H., additional, Park, H.K., additional, Yoon, C.W., additional, Chan, B., additional, Teoh, H.L., additional, Paliwal, P., additional, Wong, L.Y.J., additional, Chen, J.T., additional, De Silva, D.A., additional, Chang, H.M., additional, Fabiaña, N., additional, Marti, J., additional, Delgado, R., additional, Martínez, A., additional, Prats, L., additional, Camps, P., additional, Liou, C.W., additional, Tan, T.Y., additional, Liu, C.F., additional, Cheng, H.H., additional, Po, H.L., additional, Lin, Y.J., additional, Chou, C.L., additional, Lin, C.H., additional, Yen, C.C., additional, Chang, Y.T., additional, Hsu, Y.T., additional, Lee, J.D., additional, Lee, M., additional, Huang, Y.C., additional, Wu, C.Y., additional, Suwanwela, N.C., additional, Chutinet, A., additional, Likitjaroen, Y., additional, Roongpiboonsopit, D., additional, Charnwut, S., additional, Dyker, A., additional, Hossain, M., additional, Muddegowda, G.K., additional, Sanyal, R., additional, Roffe, C., additional, Natarajan, I., additional, Finney, K., additional, Sztriha, L., additional, Teo, J., additional, Chan, F.K., additional, Lim, J., additional, Chitando, B., additional, Clarke, B., additional, Patel, B., additional, Khan, U., additional, Ghatala, R., additional, Trippier, S., additional, Kalra, L., additional, Manawadu, D., additional, Sikondari, N., additional, Aeron-Thomas, J., additional, Sunman, W., additional, Wilkes, G., additional, Richardson, C., additional, Buch, A., additional, Jackson, B., additional, Halse, O., additional, Mashate, S., additional, Wilding, P., additional, Nguyen, V., additional, Qadiri, M.R., additional, Rashed, K., additional, Board, S., additional, Buckley, C., additional, Smith, C., additional, James, M., additional, Keenan, S., additional, Bouring, A., additional, England, T., additional, Donnelly, R., additional, Scott, J., additional, Maddula, M., additional, Beavan, J., additional, Perry, R., additional, Francia, N., additional, Watchhurst, C., additional, Banaras, A., additional, Ashton, A., additional, Mistri, A., additional, Musarrat, K., additional, Eveson, D., additional, Kallingal, J., additional, Perez, J., additional, Harrison, L., additional, Marsden, T., additional, Furnace, J., additional, Clarke, R., additional, Reid, J., additional, Warburton, E., additional, Macleod, M.J., additional, Mitchell, J., additional, Day, D., additional, Church, N., additional, Amis, E., additional, Price, C., additional, Rodgers, H., additional, Whiting, R., additional, Hussain, M., additional, Harvey, M., additional, Brown, S., additional, Foot, J., additional, Tryambake, D., additional, Broughton, D., additional, Bergin, A., additional, Annamalai, A., additional, Dixon, L., additional, Weir, N., additional, Blank, C., additional, Harkness, K., additional, Ali, A., additional, Richards, E., additional, Stocks, K., additional, Bruce, D.W., additional, Wani, M., additional, Anjum, T., additional, Krishnan, M., additional, Nguyen Huy, T., additional, Le Tuan, A. Truong, additional, Cam, L. Dam Thi, additional, Kim, T. Ngo Thi, additional, Nguyen, B. Pham, additional, Dat, A. Nguyen, additional, Van, C. Nguyen, additional, Duy, T. Mai, additional, Viet, P. Dao, additional, Tien, D. Nguyen, additional, Van, T. Vo, additional, Le Kim, K., additional, Ngoc, T. Bui, additional, Le Thanh, T. Tran, additional, Hoanh, S. Nguyen, additional, Phuoc, S. Pham, additional, Van, T. Tran, additional, Thi, B. Doan, additional, Thu, H. Nguyen Thi, additional, Duy, M. Nguyen, additional, and Van, D. Ngo, additional
Published: 2019
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36. Low-Dose vs Standard-Dose Alteplase in Acute Lacunar Ischemic Stroke: The ENCHANTED Trial.

Author: Zien Zhou, Delcourt, Candice, Chao Xia, Sohei Yoshimura, Carcel, Cheryl, Torii-Yoshimura, Takako, Shoujiang You, Malavera, Alejandra, Xiaoying Chen, Hackett, Maree L., Woodward, Mark, Chalmers, John, Jianrong Xu, Robinson, Thompson G., Parsons, Mark W., Demchuk, Andrew M., Lindley, Richard I., Mair, Grant, Wardlaw, Joanna M., and Anderson, Craig S.
Published: 2021
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37. Intensive versus guideline‐recommended blood pressure reduction in acute lacunar stroke with intravenous thrombolysis therapy: The ENCHANTED trial.

Author: Zhou, Zien, Xia, Chao, Carcel, Cheryl, Yoshimura, Sohei, Wang, Xia, Delcourt, Candice, Malavera, Alejandra, Chen, Xiaoying, Mair, Grant, Woodward, Mark, Chalmers, John, Demchuk, Andrew M., Lindley, Richard I., Robinson, Thompson G., Parsons, Mark W., Wardlaw, Joanna M., and Anderson, Craig S.
Subjects: LACUNAR stroke, BLOOD pressure, INTRAVENOUS therapy, TREATMENT effectiveness, LOGISTIC regression analysis, REGRESSION analysis
Abstract: Background and purpose: This was an investigation of the differential effects of early intensive versus guideline‐recommended blood pressure (BP) lowering between lacunar and non‐lacunar acute ischaemic stroke (AIS) in the BP arm of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED). Methods: In 1,632 participants classified as having definite or probable lacunar (n = 454 [27.8%]) or non‐lacunar AIS according to pre‐specified definitions based upon clinical and adjudicated imaging findings, mean BP changes over days 0–7 were plotted, and systolic BP differences by treatment between subgroups were estimated in generalized linear models. Logistic regression models were used to estimate the BP treatment effects on 90‐day outcomes (primary, an ordinal shift of modified Rankin scale scores) across lacunar and non‐lacunar AIS after adjustment for baseline covariables. Results: Most baseline characteristics, acute BP and other management differed between lacunar and non‐lacunar AIS, but mean systolic BP differences by treatment were comparable at each time point (all pinteraction > 0.12) and over 24 h post‐randomization (−5.5, 95% CI −6.5, −4.4 mmHg in lacunar AIS vs. −5.6, 95% CI −6.3, −4.8 mmHg in non‐lacunar AIS, pinteraction = 0.93). The neutral effect of intensive BP lowering on functional outcome and the beneficial effect on intracranial haemorrhage were similar for the two subgroups (all pinteraction > 0.19). Conclusions: There were no differences in the treatment effect of early intensive versus guideline‐recommended BP lowering across lacunar and non‐lacunar AIS. [ABSTRACT FROM AUTHOR]
Published: 2021
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38. Clinical prognosis of FLAIR hyperintense arteries in ischaemic stroke patients: a systematic review and meta-analysis.

Author: Zien Zhou, Malavera, Alejandra, Yoshimura, Sohei, Delcourt, Candice, Mair, Grant, Al-Shahi Salman, Rustam, Demchuk, Andrew M., Wardlaw, Joanna M., Lindley, Richard I., Anderson, Craig S., and Zhou, Zien
Subjects: META-analysis, STROKE patients, CLINICAL trial registries, ARTERIES, PROGNOSIS, ADOLESCENT idiopathic scoliosis
Abstract: Objective: We performed a systematic review and meta-analysis to determine the association of fluid-attenuated inversion recovery (FLAIR) hyperintense arteries (FLAIR-HAs) on brain MRI and prognosis after acute ischaemic stroke (AIS).Methods: We searched Medline, Embase and Cochrane Central Register of Controlled Trials for studies reporting clinical or imaging outcomes with presence of FLAIR-HAs after AIS. Two researchers independently assessed eligibility of retrieved studies and extracted data, including from the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED). Outcomes were unfavourable functional outcome (primary, modified Rankin scale scores 3-6 or 2-6), death, intermediate clinical and imaging outcomes. We performed subgroup analyses by treatment or types of FLAIR-HAs defined by location (at proximal/distal middle cerebral artery (MCA), within/beyond diffusion-weighted imaging (DWI) lesion) or extent.Results: We included 36 cohort studies (33 prospectively collected) involving 3577 patients. FLAIR-HAs were not associated with functional outcome overall (pooled risk ratio 0.87, 95% CI 0.71 to 1.06), but were significantly associated with better outcome in those receiving endovascular therapy (0.56, 95% CI 0.41 to 0.75). Contrary to FLAIR-HAs at proximal MCA or within DWI lesions, FLAIR-HAs beyond DWI lesions were associated with better outcome (0.67, 95% CI 0.57 to 0.79). FLAIR-HAs favoured recanalisation (1.21, 95% CI 1.06 to 1.38) with increased risk of intracerebral haemorrhage (2.07, 95% CI 1.37 to 3.13) and early neurological deterioration (1.93, 95% CI 1.30 to 2.85).Conclusions: FLAIR-HAs were not associated with functional outcome overall but were associated with outcome after endovascular therapy for AIS. FLAIR-HAs were also associated with early recanalisation or haemorrhagic complications, and early neurologic deterioration.Prospero Registration Number: CRD42019131168. [ABSTRACT FROM AUTHOR]
Published: 2020
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39. Novel methods to optimize the effects of transcranial direct current stimulation: a systematic review of transcranial direct current stimulation patents

Author: Malavera, Alejandra, primary, Vasquez, Alejandra, additional, and Fregni, Felipe, additional
Published: 2015
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40. Optimal random frequency range in transcranial pulsed current stimulation indexed by quantitative electroencephalography

Author: Morales-Quezada, Leon, primary, Castillo-Saavedra, Laura, additional, Cosmo, Camila, additional, Doruk, Deniz, additional, Sharaf, Ibrahim, additional, Malavera, Alejandra, additional, and Fregni, Felipe, additional
Published: 2015
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41. Predictive Accuracy of Clinicians Estimates of Death and Recovery after Acute Intracerebral Hemorrhage: Pre-Specified Analysis in INTERACT3 Study.

Author: Ouyang, Menglu, Ma, Lu, Chen, Xiaoying, Wang, Xia, Billot, Laurent, Li, Qiang, Malavera, Alejandra, Li, Xi, Muñoz-Venturelli, Paula, Silva, Asita De, Nguyen, Thang Huy, Wahab, Kolawole W., Pandian, Jeyaraj Dural, Wasay, Mohammad, Pontes-Neto, Octavio Marques, Abanto, Carlos, Arauz, Antonio, You, Chao, Hu, Xin, and Song, Lili
Abstract: Introduction: Accurately predicting a patient’s prognosis is an important component of decision-making in intracerebral hemorrhage (ICH). We aimed to determine clinicians’ ability to predict survival, functional recovery, and return to premorbid activities in patients with ICH. Methods: Pre-specified secondary analysis of the third intensive care bundle with blood pressure reduction in acute cerebral hemorrhage trial (INTERACT3), an international, multicenter, stepped-wedge cluster randomized controlled trial. Clinician perspectives on prognosis were collected at hospital admission and Day 7 (or before discharge). Prognosis questions were the likelihood of (i) survival at 48 h and 6 months, (ii) favorable functional outcome (recovery walking and self-care), and (iii) return to usual activities at 6 months. Clinician predictions were compared with actual outcomes. Results: Most clinician participants were from neurosurgery (75%) with a median of 8 working years (IQR 5–14) of experience. Of the 6,305 randomized patients who survived 48 h, 213 (3.4%) were predicted to die (positive predictive value [PPV] 0.99, 95% confidence interval [CI] 0.99–0.99). Of 5,435 patients who survived 6 months, 209 (3.8%) were predicted to die (PPV 0.93, 95% CI: 0.92–0.93). Predictions on the favorable functional outcome (PPV 0.54, 95% CI: 0.52–0.56) and satisfied ability to return to usual activities (PPV 0.50, 95% CI: 0.49–0.52) were poor. Prediction accuracy varied by working years and region of practice. Conclusions: In patients with ICH, clinician estimates of death are very good but conversely they are poor in predicting higher levels of functional recovery and activities. [ABSTRACT FROM AUTHOR]
Published: 2024
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42. The effect of blood pressure lowering medications on the prevention of episodic migraine: A systematic review and meta-analysis.

Author: Carcel, Cheryl, Haghdoost, Faraidoon, Shen, Joanne, Nanda, Puneet, Bai, Yu, Atkins, Emily, Torii-Yoshimura, Takako, Clough, Alexander J., Davies, Leo, Cordato, Dennis, Griffiths, Lyn R., Balicki, Grace, Wang, Xia, Vidyasagar, Kota, Malavera, Alejandra, Anderson, Craig S., Zagami, Alessandro S., Delcourt, Candice, and Rodgers, Anthony
Subjects: *BLOOD pressure, *ANGIOTENSIN-receptor blockers, *MIGRAINE, *ACE inhibitors, *CALCIUM antagonists
Abstract: Background: Currently, only a few specific blood pressure-lowering medications are recommended for migraine prevention. Whether benefits extend to other classes or drugs is uncertain. Methods: Embase, MEDLINE, and the Cochrane Central Registry of Controlled Trials were searched for randomized control trials on the effect of blood pressure-lowering medications compared with placebo in participants with episodic migraine. Data were collected on four outcomes – monthly headache or migraine days, and monthly headache or migraine attacks, with a standardised mean difference calculated for overall. Random effect meta-analysis was performed. Results: In total, 50 trials (70% of which were crossover) were included, comprising 60 comparisons. Overall mean age was 39 years, and 79% were female. Monthly headache days were fewer in all classes compared to placebo, and this was statistically significant for all but one class: alpha-blockers −0.7 (95% CI: −1.2, −0.1), angiotensin-converting enzyme inhibitors −1.3 (95% CI: −2.9, 0.2), angiotensin II receptor blockers −0.9 (−1.6, −0.1), beta-blocker −0.4 (−0.8, −0.0) and calcium channel blockers −1.8 (−3.4, −0.2). Standardised mean difference was significantly reduced for all drug classes and was separately significant for numerous specific drugs: clonidine, candesartan, atenolol, bisoprolol, metoprolol, propranolol, timolol, nicardipine and verapamil. Conclusion: Among people with episodic migraine, a broader number of blood pressure-lowering medication classes and drugs reduce headache frequency than those currently included in treatment guidelines. Trial Registration: The study was registered at PROSPERO (CRD42017079176). [ABSTRACT FROM AUTHOR]
Published: 2023
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43. Implementation of low-intensity thrombolysis monitoring care in routine practice: process evaluation of the Optimal Post rtPA-IV Monitoring in Acute Ischemic Stroke (OPTIMISTmain) study in the United States.

Author: Ouyang M, González F, Montalbano M, Pruski A, Jan S, Wang X, Johnson B, Summers DV, Khatri P, Malavera A, Iacobelli M, Faigle R, Munoz-Venturelli P, Urrutia Goldsack F, Day D, Robinson TG, Durham AC, Ebraimo A, Song L, Sui Y, Wan Zaidi WA, Lindley RI, Delcourt C, Urrutia VC, Anderson CS, and Liu H
Abstract: Introduction: The ongoing OPTIMISTmain study, an international, multicenter, stepped-wedge cluster randomized trial, aims to determine effectiveness and safety of low-intensity versus standard monitoring in thrombolysis-treated patients with mild-to-moderate acute ischemic stroke (AIS). An embedded process evaluation explored integration and impact of the intervention on care processes at participating US sites., Methods: A mixed-methods approach with quantitative and qualitative data were collected between September 2021 and November 2022. Implementer surveys were undertaken at pre- and post-intervention phases to understand the perceptions of low-intensity monitoring strategy. A sample of stroke care nurses were invited to participate in semi-structured interviews at an early stage of post-intervention. Qualitative data were analyzed deductively using the normalization process theory; quantitative data were tabulated., Results: Interviews with 21 nurses at 8 hospitals have shown low-intensity monitoring was well accepted, as there were less time constraints and reduced workload for each patient. There were initial safety concerns over missing deteriorating patients and difficulties in changing established routines. Proper training, education, and communication, and changing the habits and culture of care, were key elements to successfully adopting the new monitoring care into routine practice. Similar results were found in the post-intervention survey (42 nurses from 13 hospitals). Nurses reported time being freed up to provide patient education (56%), daily living care (50%), early mobilization (26%), mood/cognition assessment (44%), and other aspects (i.e. communication, family support)., Conclusions: Low-intensity monitoring for patients with mild-to-moderate acute ischemic stroke, facilitated by appropriate education and organizational support, appears feasible and acceptable at US hospitals., (S. Karger AG, Basel.)
Published: 2024
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44. Process evaluation of complex interventions in non-communicable and neglected tropical diseases in low- and middle-income countries: a scoping review.

Author: Lazo-Porras M, Liu H, Ouyang M, Yin X, Malavera A, Bressan T, Guzman-Vilca WC, Pacheco N, Benito M, Miranda JJ, Moore G, Chappuis F, Perel P, and Beran D
Subjects: Humans, Developing Countries, Health Personnel
Abstract: Objectives: The aim of this review is to map out the use of process evaluation (PE) in complex interventions that address non-communicable diseases (NCDs) and neglected tropical diseases (NTDs) to identify gaps in the design and conduct, as well as strengths, limitations and implications, of this type of research in low- and middle-income countries (LMICs)., Design: Scoping review of PE studies of complex interventions implemented in LMICs. Six databases were searched focused on studies published since 2008., Data Sources: Embase, PubMed, EbscoHost, Web of Science (WOS), Virtual Health Library (VHL) Regional Portal and Global Index Medicus: Regional Indexes AIM (AFRO), LILACS (AMRO/PAHO), IMEMR (EMRO), IMSEAR (SEARO), WPRIM (WPRO) Global Index Regional Indexes, MEDLINE, SciELO., Eligibility Criteria: Studies conducted in LMICs on PEs of randomised controlled trials (RCTs) and non-RCTs published between January 2008 and January 2020. Other criteria were studies of interventions for people at risk or having physical and mental NCDs, and/or NTDs, and/or their healthcare providers and/or others related to achieve better health for these two disease groups. Studies were excluded if they were not reported in English or Spanish or Portuguese or French, not peer-reviewed articles, not empirical research and not human research., Data Extraction and Synthesis: Data extracted to be evaluated were: available evidence in the utilisation of PE in the areas of NCDs and NTDs, including frameworks and theories used; methods applied to conduct PEs; and in a subsample, the barriers and facilitators to implement complex interventions identified through the PE. Variables were extracted and categorised. The information was synthesised through quantitative analysis by reporting frequencies and percentages. Qualitative analysis was also performed to understand facilitators and barriers presented in these studies. The implications for PEs, and how the information from the PE was used by researchers or other stakeholders were also assessed in this approach., Results: 303 studies were identified, 79% were for NCDs, 12% used the label 'PE', 27% described a theory or framework for the PE, and 42% used mixed methods to analyse their findings. Acceptability, barriers and facilitators to implement the interventions, experiences and perceptions, and feasibility were the outcomes most frequently evaluated as part of the PEs. Barriers and facilitators themes identified were contextual factors, health system factors, human resources, attitudes and policy factors., Conclusions: PEs in NCDs and NTDs are used in LMICs with a wide variety of methods. This review identified many PEs that were not labelled by the authors as such, as well as a limited application of PE-related theories and frameworks, and heterogeneous reporting of this type of study., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Published: 2022
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45. Brain Imaging Signs and Health-Related Quality of Life after Acute Ischemic Stroke: Analysis of ENCHANTED Alteplase Dose Arm.

Author: Chen X, Delcourt C, Sun L, Zhou Z, Yoshimura S, You S, Malavera A, Torii-Yoshimura T, Carcel C, Arima H, Hackett ML, Robinson T, Song L, Wang X, Lindley RI, Chalmers J, and Anderson CS
Subjects: Administration, Intravenous, Aged, Brain diagnostic imaging, Brain physiopathology, Brain Ischemia diagnostic imaging, Brain Ischemia physiopathology, Cerebral Angiography, Computed Tomography Angiography, Female, Fibrinolytic Agents adverse effects, Humans, Magnetic Resonance Angiography, Male, Middle Aged, Predictive Value of Tests, Randomized Controlled Trials as Topic, Risk Assessment, Risk Factors, Stroke diagnostic imaging, Stroke physiopathology, Time Factors, Tissue Plasminogen Activator adverse effects, Treatment Outcome, Brain drug effects, Brain Ischemia drug therapy, Fibrinolytic Agents administration & dosage, Neuroimaging, Quality of Life, Stroke drug therapy, Thrombolytic Therapy adverse effects, Tissue Plasminogen Activator administration & dosage
Abstract: Background and Purpose: The influence of specific brain lesions on health-related quality of life (HRQoL) after acute ischemic stroke (AIS) is uncertain. We aimed to identify imaging predictors of poor HRQoL in alteplase-treated participants of the alteplase dose arm of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED)., Methods: ENCHANTED was an international trial of low- versus standard-dose intravenous alteplase in AIS patients, with functional outcome (modified Rankin scale [mRS]) and HRQoL on the 5-dimension European Quality of Life Scale (EQ-5D) assessed at 90 days post-randomization. Brain images were analyzed centrally by trained assessors. Multivariable logistic regression was undertaken in the study population randomly divided (2:1) into training (development) and validation (performance) groups, with age (per 10-year increase), ethnicity, baseline National Institutes of Health Stroke Scale (NIHSS) score, diabetes mellitus, premorbid function (mRS score 0 or 1), and proxy respondent, forced into all models. Data are presented with odds ratios (ORs) and 95% confidence intervals (CIs)., Results: Eight prediction models were developed and validated in 2,526 AIS patients (median age 67.5 years; 38.4% female; 61.7% Asian) with complete brain imaging and 90-day EQ-5D utility score data. The best performance model included acute ischemic changes in the right (OR 1.69, 95% CI: 1.24-2.29) and deep (OR 1.50, 95% CI: 1.03-2.19) middle cerebral artery (MCA) regions. Several background features of brain frailty - atrophy, white matter change, and old infarcts - were significantly associated with adverse physical but not emotional HRQoL domains., Conclusions: In thrombolysed AIS patients, right-sided and deep ischemia within the MCA territory predict poor overall HRQoL, whilst features of old cerebral ischemia are associated with reduced physical HRQoL., (© 2020 S. Karger AG, Basel.)
Published: 2020
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