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2. The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial

Author

Robinson, Thompson, Miranda, J. Jaime, Anderson, Craig S., You, Chao, Song, Lili, Parry-Jones, Adrian, Sprigg, Nikola, Durrans, Sophie, Harris, Caroline, Bamford, Ann, Smith, Olivia, Herbert, Robert, Chen, Christopher, Whiteley, William, Hu, Rong, Billot, Laurent, Li, Qiang, Mysore, Jayanthi, Hu, Xin, Zhang, Yao, Liu, Feifeng, Sakamoto, Yuki, You, Shoujiang, Han, Qiao, Crutzen, Bernard, Li, Yunke, Cheung, Emily, Jan, Stephen, Liu, Hueiming, Ouyang, Menglu, Sun, Lingli, Chu, Honglin, Anjum, Anila, Gonzalez Mc Cawley, Francisca, Del Rio, Alejandra, Rimoli, Bruna, Cerantola, Rodrigo, Jeevarajah, Thanushanthan, Kannangara, Madhushani, Joseph, Andrene, Nanayakkara, Chamath, Chen, Xiaoying, Malavera, Alejandra, Zhang, Chunmiao, Yang, Zhao, Li, Brook, Meng, Zhuo, Liu, Leibo, Ning, Yi, Dong, Le, Armenis, Manuela, Lim, Joyce, Monaghan, Helen, Ma, Lu, Li, Xi, Luo, Rui, Cheng, Guojuan, Dong, Yilin, Liu, Ziqin, Wang, Shuihong, Zhang, Ying, Cheng, Jipeng, Shi, Hui, Li, Wenjing, Mou, Langming, Yi, Ping, Chen, Chen, Chen, Xue, Weerawardena, Shalomi, Ellawala, Poornima, Ranasinghe, Enalee, Rodrigo, Chrishmi, Wahab, Kolawala, Adeniyi, Sunday, Pandian, Jeyaraj, Khanna, Megha, Muñoz Venturelli, Paula, González, Francisca, Urrutia Goldsack, Francisca, Wasay, Mohammad, Begum, Dilshad, Pontes-Neto, Octavio, Camilo, Millene, Dias, Francisco, Vincenzi, Octavio, Moro, Carla, Santos, Renata, Texeira, Nara, Longo, Alexandre, Liberato, Rafaela, Martins, Sheila, Pille, Arthur, Chwal, Bruna, Silva, Isabel, Titton, Natacha, Weiss, Gustavo, Mora, Daissy, Ouriques, Magda, Carbonera, Leonardo, Bazan, Rodrigo, Modolo, Gabriel, Winckler, Fernanda, Miranda, Luana, Souza, Juli, Rojo, Alexis, Uslar, Wilhelm, Medel, Lorena, Lopez, Javiera, Herrero, Diego, Lavados, Pablo, Vargas Latorre, Barbara, Conejan, Nathalie, Esparza, Tomas, Sotomayor, Patricio, Wenger, Denisse, Gigoux, Juan Pablo, Letelier, Aldo, Acevedo, Lilian, Moya, Vivianne, Figueroa, Cristian, Vallejos, Nicol, Guerrero, Rodrigo, Velasquez, Mauricio, Vallejos, Jose, Pallauta, Kimerly, Santibanez, Tamara, Queirolo, Angelo, Lobos, Andrea, Jiang, Yongming, Li, Weimin, Huang, Wei, Luo, Ke, Liu, Gangying, Tang, Guanghai, Yang, Guang, Jiang, Hongtao, Zhang, Xu, Jing, Hongyan, Zhu, Sheng, Pu, Bo, Lv, Dong, Kang, Hui, Hu, Qiuping, She, Xiaochun, Jiang, Xiaoming, Chen, Yanli, Yang, Shenghua, He, Jianjun, Li, Zongping, Cheng, Gang, Huang, Hailin, Wang, Xiaoyi, Lin, Jianqiong, Chen, Minhui, Yang, Chenghao, Ding, Hao, Deng, Yunliang, Luo, Fei, Zhang, Rongjun, Wang, Xiaofeng, Zhang, Hongbing, Yang, Xiaoliang, Zhang, Yang, Yang, Chengyi, He, Yu, Liu, Feng, Wang, Rongjie, Zhang, Yuhui, Xin, Xiaodong, Feng, Bin, Hao, Wanru, Song, Chang, Guo, Yun, Jiang, Dehua, Chen, Jie, Tang, Changtong, Zhu, Hongliang, Li, Xin, Cui, Jin, Xu, Haidong, Li, Boyang, Tang, Fusheng, Li, Yuanbin, Gao, Min, Yang, Bo, Xu, Xuejun, Deng, Bing, Zheng, Yi, Ge, Yuanhong, Chen, Keyu, Liu, Yang, Li, Xinshen, Zhong, Tingting, Xu, Jianfeng, Zhang, Hai, Wang, Jiyue, Zhu, Jianxin, Sun, Hanyu, Yu, Fuhua, Zhang, Xueguang, Xu, Jianguo, Zhang, Mingsen, Wang, Bin, Ma, Yiming, Jiang, Donglin, Zhou, Jun, Liu, Cong, Nie, Wenhong, Li, Mingguo, Tian, Tao, Li, Yong, He, Mingfang, Tu, Xiaolong, Wu, Zhengjun, Liu, Hong, Zhong, Dongsheng, Jiang, Rongcai, Sun, Jian, Tian, Ye, Wei, Yingsheng, An, Shuo, Wei, Pingbo, Luo, Le, Lin, Bin, Liu, Gang, Wen, Yan, Cai, Qiang, Chen, Qianxue, Lei, Pan, Li, Zhiyang, Zhang, Meifang, He, Jiaquan, Chen, Yan, Liu, Jun, Liu, Xinghai, Li, Junyan, Chen, Min, Wang, Jing, Zhou, Bingzhi, Ye, Baichun, Zhang, Jiancheng, Zhang, Manyuan, Pan, Xuming, Yu, Xiaoxiang, Xu, Jian, Xiao, Qingbao, Wang, Yuefei, Tao, Liang, Shi, Lin, Zheng, Niandong, You, Guoliang, Lei, Bo, Chen, Shu, Wu, Honggang, Hu, Jin, Zhao, Jianlan, Yu, Jian, Yuan, Qiang, Du, Zhuoying, Tang, Xielin, Li, Qianke, Liu, Shenghua, Yang, Feilong, Xiao, Kui, Luo, Chao, Wang, Guang, Che, Xudong, Teng, Zhipeng, Wan, Wenwu, Li, Jun, Liu, Yu, Fan, Mingbo, Zhang, Tao, Cai, Lun, Ma, Yuan, Ma, Zhifeng, Li, Bin, He, Linlin, Li, Jinghui, Zhang, Weibing, Zhang, Shuxin, Zhang, Hongzhen, Dai, Yingguang, Lei, Jun, Mao, Lei, Huang, Yiyang, Zhou, Zhi, Chen, Ping, Chen, Fang, Wei, Pan, Li, Tiangui, Chen, Honglin, Zeng, Mengfei, Mou, Kejie, Xue, Jun, Jiang, Yong, Tang, Xiaoping, Chen, Tao, Zhang, Yalan, Xu, Yanbing, Gu, Yuchen, Chen, Lei, Zhao, Yujun, Yang, Bin, Kuai, Peng, Wang, Xi, Yang, Yuwang, Hu, Xueling, Zhang, Huitian, Yang, Yintao, Wang, Weifeng, Zhang, Junyi, Cheng, Wei, Zhang, Xiaoxue, Ma, Xiaowen, He, Qin, Zhang, Li, Gao, Rong, Liu, Huixiang, Ye, Jingwei, Xu, Ping, Wu, Xin, Yuan, Yuan, Zou, Peng, Zhang, Zhen, Cheng, Jiyong, Zhou, Zhangming, Zeng, Yijun, Liang, Zhang, Du, Deming, Yu, Shui, Cao, Yongjun, Xu, Jiaping, Huang, Zhichao, Chen, Dongqin, Xiao, Wenfeng, Zhu, Li, Yuan, Miao, Wang, Yuhai, Shi, Dongliang, Hu, Xu, Xiang, Dingchao, Shi, Like, Wang, Hongqin, Yang, Liu, Miao, Wang, Hu, Yiyi, Zhao, Yuchun, Hu, Xi, Zhou, Weiduo, Sun, Chao, Tang, Dong, Yao, Kun, You, Jin, Chen, Shishi, Yao, Jianmin, Li, Huanmei, Liu, Jinmei, Bai, Ailin, Yi, Yong, Deng, Qingshan, Luo, Peng, Wang, Han, Jiang, Jingcheng, Yang, Qingwei, He, Shunpo, Wang, Jun, Chen, Yu, He, Hua, Deng, Yuyang, Cao, Zhikai, Yi, Xuxia, Luo, Jinbiao, Luo, Shuang, Gong, Min, Liu, Li, Gao, Xuejun, Liu, Jia, Wu, Li'e, Zhang, Jia, Sun, Hongying, Li, Xinhui, Jia, Lu, Wu, Jianbing, Zhang, Jie, Zhang, Huajun, Du, Chunfu, Li, Shun, Yang, Xiaobin, He, Jie, Liao, Lei, Zhou, Gezhi, Dong, Wentao, Chen, Yunxiang, Lin, Xiaofeng, Shui, Xujian, Zhang, Peng, Zhao, Yuan, Yang, Hongli, Zhao, Wenbin, Zhang, Xiaoyi, Chen, Jincao, Wu, Qian, Dai, Xuan, Tang, Baogui, Wang, Yinjuan, Liu, Tao, Zhang, Haixia, Duan, Faliang, Luo, Ming, Jiao, Qingfang, Lei, Guoliang, Wang, Dong, Song, Chunwang, Tan, Haopeng, Ye, Feng, Qin, Xinghu, Liang, Xiaolong, Liu, Junling, Yang, Lang, Yang, Jie, Lin, Yapeng, Yang, Qian, Ma, Xuntai, Qi, Yinkuang, Pan, Baogen, Jiang, Caixia, Ye, Zhanying, Dong, Ce, Yue, Xiongfei, Yang, Xiaopeng, Maimaitiyiming, Tuoheti, Dong, Jun, Wu, Yonggang, Gao, Feng, Zhao, Deqiang, Zhang, Xinghai, Wang, PengJun, Jiang, Hongbo, Li, Jianping, Zhang, Wei, Chen, Jing, Tong, Haibo, Wang, Yonghong, Qiao, Kaipeng, Guo, Fuyou, Zhang, Mingchu, Hu, Yan, Feng, Mengzhao, Song, Dengpan, Zuo, Yi, Chen, Shangjun, Qian, Chao, Li, Baoming, Ma, Jingku, Zhang, Sunfu, Kong, Bin, Dong, Xingyu, Fang, Sheng, Lu, Bin, Li, Yang, Yang, Yongling, Yu, Hong, Sun, Huaiyu, Wang, Yue, Wang, Weimin, Li, Tong, Li, Shengli, Xu, Zhiming, Wang, Yongyi, Dong, Qiang, Tang, Yuping, Chu, Heling, Lu, Ying, Wang, Zhong, Sun, Xiaoou, Zhao, Jianhua, Yang, Shuaifeng, Qian, Xiying, Saroja, Aralikatte Onkarappa, Naik k, Ravishankar, Chindhi, Sandip, Pampaniya, Nakul, Amaresh, Kurubara, Iype, Thomas, R, Dileep, Rajan, Reeja, Panicker, Praveen, Das, Rupjyoti, Choudhury, Nupur, Gohain, Pankaja, Webster, Jemin, Pakma, Biyol, Sangi, Lalbiak, Sebastian, Ivy, Aggrawal, Gaurav, Raj, Komal, Rajoura, Deepankshi, Singh, Sulena, Aggrawal, Varun, Narang, Amit, Arauz, Antonio, Cano-Nigenda, Vanesa, López-Mena, Diego, Valdez-Ruvalcaba, Héctor, Toledo-Treviño, Roberto, Obiako, Reginald, Abubakar, Sani, Emeka, Oguike, Olayemi, Balogun, Lois, Melika, Philip, Ibinaiye, Comfort O, Olurishe, Okubadejo, Njideka, Agabi, Osigwe, Ojo, Oluwadamilola, Wahab, Kolawole, Bello, Abiodun, Ibukun, Oyinloye, Sanayaolu, Olufemi, Jimoh, Abdulraheem, Waheed, Shahid, Kamal, Dr.Ayeesha, Shoaib, Raja Farhat, Orooj, Fizza, Majid, Sadaf, Zehra, Taskeen, Khan, Abdus Salam, Shanker, Ravi, Syed, Nadir Ali, Ahmad, Nashwa, Abanto, Carlos, Valencia, Ana, Barrientos, Danny, Ramirez, Jorge, Calle, Pilar, Palliyeguruge, Dilum, Muthucumarana, Sumudu, Ratnayaka, Shiroma, Ganihiarachchi, Dilhara, Bandaranayake, Arundathi, Somaratne, S.D.B, Narayana, Saumya, Gallage, Sithara, Senanayake, Bimsara, Samarasiri, Udari, Luke, Dunya, Sivapathasundaram, Mythily, Sahadevan, Vithoosan, Rasmi, Amani, Deshaka, Yuran, Fernando, Nilukshi, Munasinghe, Aruna, Rathnapriya, Kapilanga, Nissanka, A.S, Karunathilake, Kanchana, Gayan, Isuru, Wijenayake, Kaminda, Gunasekara, Hasitha, Vidyarathne, Jagath, Keshavaraj, Ajantha, Janarthanan, Kanagasabapathy, Gerald Jeevathasan, Arhivalaky, Sivamainthan, Sivaram, John Priyanth, Mathyamuthan, John Priyanth, Abirami, Rajendiran, Thambippillai, Alwis, Sanjeewa, Gunasekare, Nushara, Liyanarachchi, Vasundara, Dissanayake, Athula, Uluwattage, Wimalasiri Mewa, Ratnayake, Gimhani, Rajinee, Charika, Jayawardana, Sakura, Peiris, Janaka, Wicramasinghe, Ranjith, Fernando, Chamila, Abbas, Jessie, Withanage, Nethmini, Bandara, Makaranda, Mai, Duy Ton, Nguyen, Van Chi, Dao, Viet Phuong, Vuong, Xuan Trung, Nguyen, Tien Dung, Dinh, Trung Hieu, Phan, Ha Quan, Bui, Quoc Viet, Phung, Dinh Tho, Pham, Quang Tho, Pham, Dinh Dai, Do, Duc Thuan, Dang, Phuc Duc, Dang, Minh Duc, Nguyen, Dang Hai, Nguyen, Thi Phuong Nga, Nguyen, Quoc Huy, Pham, Quoc Dai, Chau, Quoc Vinh, Tai, Vinh Thy Van, Le, Tran Vinh, Le, Cong Tri, Tran, Ha Mai Khuong, Nguyen, Huu Khanh, Ngyen, Hoang Minh Thao, Vo, Duc Chien, Nguyen, Thai My Phuong, Tran, Trung Thanh, Vo, Thi Hanh Vi, Cao, Hao Nhien, Nguyen, Ba Thang, Le, Thi Ngoc Suong, La, Thien Duc, Pham, Chi Duc, Thai, Huy, Muñoz-Venturelli, Paula, de Silva, Asita, Thang, Nguyen Huy, Wahab, Kolawole W, Pandian, Jeyaraj D, Pontes-Neto, Octavio M, Shi, Haiping, Wang, Xia, Zhao, Yang, Li, Hao, Liu, Yi, Jiang, Yan, Wu, Bo, Liu, Ming, and Anderson, Craig S

Published
2023
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3. Nonprofit Organizations of the Fourth Sector That Promote Education Social Solidarity Economy in the Fourth Industrial Revolution of Medellin, Colombia

Author

Piedrahita, Juan Santiago Calle, Pineda, Sandra Milena Malavera, Pineda, Paula Andrea Malavera, Leitão, João, Series Editor, Devezas, Tessaleno, Series Editor, Sánchez-Hernández, María Isabel, editor, Carvalho, Luísa, editor, Rego, Conceição, editor, Lucas, Maria Raquel, editor, and Noronha, Adriana, editor

Published
2021
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5. A brassinosteroid functional analogue increases soybean drought resilience

Author

Lucia Sandra Perez-Borroto, María Carla Guzzo, Gisella Posada, Andrea Natalia Peña Malavera, Atilio Pedro Castagnaro, Justo Lorenzo Gonzalez-Olmedo, Yamilet Coll-García, and Esteban Mariano Pardo

Subjects
Medicine, Science
Abstract

Abstract Drought severely affects soybean productivity, challenging breeding/management strategies to increase crop resilience. Hormone-based biostimulants like brassinosteroids (BRs) modulate growth/defence trade-off, mitigating yield losses; yet, natural molecule's low stability challenges the development of cost-effective and long-lasting analogues. Here, we investigated for the first time the effects of BR functional analogue DI-31 in soybean physiology under drought by assessing changes in growth, photosynthesis, water relations, antioxidant metabolism, nodulation, and nitrogen homeostasis. Moreover, DI-31 application frequencies' effects on crop cycle and commercial cultivar yield stabilisation under drought were assessed. A single foliar application of DI-31 favoured plant drought tolerance, preventing reductions in canopy development and enhancing plant performance and water use since the early stages of stress. The analogue also increased the antioxidant response, favouring nitrogen homeostasis maintenance and attenuating the nodular senescence. Moreover, foliar applications of DI-31 every 21 days enhanced the absolute yield by ~ 9% and reduced drought-induced yield losses by ~ 7% in four commercial cultivars, increasing their drought tolerance efficiency by ~ 12%. These findings demonstrated the practical value of DI-31 as an environmentally friendly alternative for integrative soybean resilience management under drought.

Published
2022
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7. Selecting putative drought-tolerance markers in two contrasting soybeans

Author

Laila Toum, Lucia Sandra Perez-Borroto, Andrea Natalia Peña-Malavera, Catalina Luque, Bjorn Welin, Ariel Berenstein, Darío Fernández Do Porto, Adrian Vojnov, Atilio Pedro Castagnaro, and Esteban Mariano Pardo

Subjects
Medicine, Science
Abstract

Abstract Identifying high-yield genotypes under low water availability is essential for soybean climate-smart breeding. However, a major bottleneck lies in phenotyping, particularly in selecting cost-efficient markers associated with stress tolerance and yield stabilization. Here, we conducted in-depth phenotyping experiments in two soybean genotypes with contrasting drought tolerance, MUNASQA (tolerant) and TJ2049 (susceptible), to better understand soybean stress physiology and identify/statistically validate drought-tolerance and yield-stabilization traits as potential breeding markers. Firstly, at the critical reproductive stage (R5), the molecular differences between the genotype’s responses to mild water deficit were explored through massive analysis of cDNA ends (MACE)-transcriptomic and gene ontology. MUNASQA transcriptional profile, compared to TJ2049, revealed significant differences when responding to drought. Next, both genotypes were phenotyped under mild water deficit, imposed in vegetative (V3) and R5 stages, by evaluating 22 stress-response, growth, and water-use markers, which were subsequently correlated between phenological stages and with yield. Several markers showed high consistency, independent of the phenological stage, demonstrating the effectiveness of the phenotyping methodology and its possible use for early selection. Finally, these markers were classified and selected according to their cost-feasibility, statistical weight, and correlation with yield. Here, pubescence, stomatal density, and canopy temperature depression emerged as promising breeding markers for the early selection of drought-tolerant soybeans.

Published
2022
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12. Implementation of Low-Intensity Thrombolysis Monitoring Care in Routine Practice: Process Evaluation of the Optimal Post rtPA-IV Monitoring in Acute Ischemic Stroke Study in the USA

Author

Ouyang, Menglu, primary, González, Francisca, additional, Montalbano, Michelle, additional, Pruski, April, additional, Jan, Stephen, additional, Wang, Xia, additional, Johnson, Brenda, additional, Summers, Debbie V., additional, Khatri, Pooja, additional, Malavera, Alejandra, additional, Iacobelli, Michael, additional, Faigle, Roland, additional, Munoz-Venturelli, Paula, additional, Urrutia Goldsack, Francisca, additional, Day, Diana, additional, Robinson, Thompson G., additional, Durham, Alice C., additional, Ebraimo, Ahtasam, additional, Song, Lili, additional, Sui, Yi, additional, Wan Zaidi, Wan Asyraf, additional, Lindley, Richard I., additional, Delcourt, Candice, additional, Urrutia, Victor Cruz, additional, Anderson, Craig S., additional, and Liu, Hueiming, additional

Published
2024
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13. Early decompressive hemicraniectomy in thrombolyzed acute ischemic stroke patients from the international ENCHANTED trial

Author

Chao Xia, Xia Wang, Richard I. Lindley, Candice Delcourt, Xiaoying Chen, Zien Zhou, Rui Guo, Cheryl Carcel, Alejandra Malavera, Zeljka Calic, Grant Mair, Joanna M. Wardlaw, Thompson G. Robinson, and Craig S. Anderson

Subjects
Medicine, Science
Abstract

Abstract Decompressive hemicraniectomy (DHC) can improve outcomes for patients with severe forms of acute ischemic stroke (AIS), but the evidence is mainly derived from non-thrombolyzed patients. We aimed to determine the characteristics and outcomes of early DHC in thrombolyzed AIS participants of the international Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED). Post-hoc analyses of ENCHANTED, an international, partial-factorial, open, blinded outcome-assessed, controlled trial in 4557 thrombolysis-eligible AIS patients randomized to low- versus standard-dose intravenous alteplase (Arm A, n = 2350), intensive versus guideline-recommended blood pressure control (Arm B, n = 1280), or both (Arms A + B, n = 947). Logistic regression models were used to identify baseline variables associated with DHC, with inverse probability of treatment weights employed to eliminate baseline imbalances between those with and without DHC. Logistic regression was also used to determine associations of DHC and clinical outcomes of death/disability, major disability, and death (defined by scores 2–6, 3–5, and 6, respectively, on the modified Rankin scale) at 90 days post-randomization. There were 95 (2.1%) thrombolyzed AIS patients who underwent DHC, who were significantly younger, of non-Asian ethnicity, and more likely to have had prior lipid-lowering treatment and severe neurological impairment from large vessel occlusion than other patients. DHC patients were more likely to receive other management interventions and have poor functional outcomes than non-DHC patients, with no relation to different doses of intravenous alteplase. Compared to other thrombolyzed AIS patients, those who received DHC had a poor prognosis from more severe disease despite intensive in-hospital management.

Published
2021
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14. Process evaluation of complex interventions in non-communicable and neglected tropical diseases in low- and middle-income countries: a scoping review

Author

David Beran, Maria Lazo-Porras, François Chappuis, J Jaime Miranda, Graham Moore, Pablo Perel, Hueiming Liu, Alejandra Malavera, Menglu Ouyang, Xuejun Yin, Wilmer Cristobal Guzman-Vilca, Tiana Bressan, Niels Pacheco, and Melissa Benito

Subjects
Medicine
Abstract

Objectives The aim of this review is to map out the use of process evaluation (PE) in complex interventions that address non-communicable diseases (NCDs) and neglected tropical diseases (NTDs) to identify gaps in the design and conduct, as well as strengths, limitations and implications, of this type of research in low- and middle-income countries (LMICs).Design Scoping review of PE studies of complex interventions implemented in LMICs. Six databases were searched focused on studies published since 2008.Data sources Embase, PubMed, EbscoHost, Web of Science (WOS), Virtual Health Library (VHL) Regional Portal and Global Index Medicus: Regional Indexes AIM (AFRO), LILACS (AMRO/PAHO), IMEMR (EMRO), IMSEAR (SEARO), WPRIM (WPRO) Global Index Regional Indexes, MEDLINE, SciELO.Eligibility criteria Studies conducted in LMICs on PEs of randomised controlled trials (RCTs) and non-RCTs published between January 2008 and January 2020. Other criteria were studies of interventions for people at risk or having physical and mental NCDs, and/or NTDs, and/or their healthcare providers and/or others related to achieve better health for these two disease groups. Studies were excluded if they were not reported in English or Spanish or Portuguese or French, not peer-reviewed articles, not empirical research and not human research.Data extraction and synthesis Data extracted to be evaluated were: available evidence in the utilisation of PE in the areas of NCDs and NTDs, including frameworks and theories used; methods applied to conduct PEs; and in a subsample, the barriers and facilitators to implement complex interventions identified through the PE. Variables were extracted and categorised. The information was synthesised through quantitative analysis by reporting frequencies and percentages. Qualitative analysis was also performed to understand facilitators and barriers presented in these studies. The implications for PEs, and how the information from the PE was used by researchers or other stakeholders were also assessed in this approach.Results 303 studies were identified, 79% were for NCDs, 12% used the label ‘PE’, 27% described a theory or framework for the PE, and 42% used mixed methods to analyse their findings. Acceptability, barriers and facilitators to implement the interventions, experiences and perceptions, and feasibility were the outcomes most frequently evaluated as part of the PEs. Barriers and facilitators themes identified were contextual factors, health system factors, human resources, attitudes and policy factors.Conclusions PEs in NCDs and NTDs are used in LMICs with a wide variety of methods. This review identified many PEs that were not labelled by the authors as such, as well as a limited application of PE-related theories and frameworks, and heterogeneous reporting of this type of study.

Published
2022
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17. The value of process evaluation for public health interventions: field-case studies for non-communicable disease prevention and management in five countries

Author

María Lazo-Porras, Lena R Brandt, Elsa Cornejo-Vucovich, Catalina A Denman, Francisco Diez-Canseco, Alejandra Malavera, Ankita Mukherjee, Menglu Ouyang, Devarsetty Praveen, Gill Schierhout, Yuewen Sun, Xuejun Yin, Puhong Zhang, and Hueiming Liu

Subjects
implementation science, process assessment, noncommunicable diseases, Public aspects of medicine, RA1-1270
Abstract

Complex interventions are needed to effectively tackle non-communicable diseases. However, complex interventions can contain a mix of effective and ineffective actions. Process evaluation (PE) in public health research is of great value as it could clarify the mechanisms and contextual factors associ­ated with variation in the outcomes, better identify effective components, and inform adaptation of the intervention. The aim of this paper is to demonstrate the value of PE through five case studies that span the research cycle. The interven­tions include using digital health, salt reduction strategies, use of fixed dose combinations, and task shifting. Insights of the methods used, and the implications of the PE findings to the project, were discussed. PE of complex interventions can refute or confirm the hypothesized mechanisms of action, thereby enabling intervention refinement, and identifying implementation strategies that can address local contextual needs, so as to improve service delivery and public health outcomes.

Published
2022
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18. Process Evaluation of an Implementation Trial: Design, Rationale, and Early Lessons Learnt From an International Cluster Clinical Trial in Intracerebral Hemorrhage

Author

Menglu Ouyang, Craig S. Anderson, Lili Song, Alejandra Malavera, Stephen Jan, Guojuan Cheng, Honglin Chu, Xin Hu, Lu Ma, Xiaoying Chen, Chao You, and Hueiming Liu

Subjects
process evaluation, stroke, intracerebral hemorrhage, clinical trial, implementation science, Medicine (General), R5-920
Abstract

BackgroundThe third INTEnsive care bundle with blood pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT3) is an ongoing, international, multicenter, stepped-wedge cluster, prospective, randomized, open, blinded endpoint assessed trial evaluating the effectiveness of a quality improvement “care bundle” for the management of patients with acute spontaneous intracerebral hemorrhage (ICH) in low- and middle-income countries (LMICs). An embedded process evaluation aims to explore the uptake and implementation of the intervention, and understand the context and stakeholder perspectives, for interpreting the trial outcomes.MethodologyThe design was informed by Normalization Process Theory and the UK Medical Research Council process evaluation guidance. Mixed methods are used to evaluate the implementation outcomes of fidelity, reach, dose, acceptability, appropriateness, adoption, sustainability, and relevant contextual factors and mechanisms affecting delivery of the care bundle. Semi-structured interviews and non-participant observations are conducted with the primary implementers (physicians and nurses) and patients/carers to explore how the care bundle was integrated into routine care. Focus group discussions are conducted with investigators and project operational staff to understand challenges and possible solutions in the organization of the trial. Data from observational records, surveys, routine monitoring data, field notes and case report forms, inform contextual factors, and adoption of the intervention. Purposive sampling of sites according to pre-specified criteria is used to achieve sample representativeness.DiscussionImplementation outcomes, and relevant barriers and facilitators to integrating the care bundle into routine practice, will be reported after completion of the process evaluation. The embedded process evaluation will aid understanding of the causal mechanisms between care bundle elements and clinical outcomes within complex health systems across diverse LMIC settings.Trial RegistrationThe INTERACT3 study is registered at ClinicalTrials.gov (NCT03209258).

Published
2022
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21. TACTICS - Trial of Advanced CT Imaging and Combined Education Support for Drip and Ship: evaluating the effectiveness of an ‘implementation intervention’ in providing better patient access to reperfusion therapies: protocol for a non-randomised controlled stepped wedge cluster trial in acute stroke

Author

Bruce C V Campbell, Geoffrey A Donnan, Stephen M Davis, Carlos Garcia-Esperon, John Attia, Frederick R Walker, Christopher Oldmeadow, Candice Delcourt, Ken Butcher, Andrew Wong, Arman Sabet, Timothy Kleinig, Helen Brown, Qing Yang, Christine L Paul, Annika Ryan, Christopher R Levi, Steven Maltby, Alejandra Malavera, Andrew Bivard, Craig Anderson, Mark Parsons, Christopher Bladin, Rohan S Grimley, Sarah Kuhle, Neil Spratt, Luke Hatchwell, Claire Muller, Martine Cox, Olivia Whalen, Rebecca J Hood, and Angela Keynes

Subjects
Medicine
Published
2022
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22. Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Author

Hankey, Graeme J., Hackett, Maree L., Almeida, Osvaldo P., Flicker, Leon, Mead, Gillian E., Dennis, Martin S., Etherton-Beer, Christopher, Ford, Andrew H., Billot, Laurent, Jan, Stephen, Lung, Thomas, Murray, Veronica, Lundström, Erik, Anderson, Craig S., Herbert, Robert, Carter, Gregory, Donnan, Geoffrey A., Nguyen, Huy-Thang, Gommans, John, Yi, Qilong, Li, Qiang, Bompoint, Severine, Barrett, Sarah, Claxton, Anne, O'Dea, Julia, Tang, Michelle, Williams, Clare, Peterson, Shenae, Drummond, Christie, Hong, Uyen-Ha, Le, Linh-Thi My, Ngo, Tram-Thi Bich, Mai, Yen-Bao, Han, Huyen-Thanh, Truong, Nhu-Quynh, Nguyen, Huong-Thi, Ngo, Hai-Thanh, Nguyen, -Thi Binh, Ha, Oanh-Thi Kieu, Nguyen, Trang-Le Huyen, Lindley, Richard I., New, Peter, Lee, Andrew, Tran, Thanh-Trung, Le, Loan-Tran Truc Mai, Kieu, Thuy-Le Vu, Nguyen, Sang-Van, Nguyen, Thuy-Anh Diem, Dang, Tam-Nhat, Phan, Hanh-Thi Truc, Vo, Loan-Thi Ngoc, Nguyen, Mai-Hue, Dang, Hanh-Cao, Tran, Hong-Thi, Dam, Linh-Thi Cam, Ngo, Trinh-Thi Kim, Pham, Thai-Nguyen Thanh, Pham, Binh-Nguyen, Dao, Nha-Thi Thanh, Nguyen, Huong-Thi Bich, Le, Linh-Thi Cam, Do, Chi-Minh, Huynh, Huy-Quoc, Tran, Giau-Thi Kim, Le, Oanh-Thi, Tran, Ly-Thi Khanh, Duong, Chinh-Dinh, Kieu, Duong-Van, Le, Na, Nguyen, Hoa-Ngoc, Le, Binh-Van, Nguyen, Long-Thanh, Nguyen, Long-Van, Dinh, Tuan-Quoc, Vo, Tan-Van, Bui, Tram-Ngoc, Hoang, Uyen-Thi To, Nguyen, Hien-Thi Bich, Nguyen, Ha-Thi Thu, Lam, Nga-Thuy, Le, Khanh-Kim, Trinh, Phuong-Thanh, Huynh, Hop-Quang, Nguyen, Thao-Thi Thu, Lu, Huyen-Ngoc, Pham, Tham-Hong, Nguyen, Sam-Hoanh, Le, Ninh-Hong, Nguyen, Giang-Truong, Doan, Bich-Thi, Pham, Sung-Phuoc, Luong, Duong-Huu, Mai, Ha-Van, Tran, Thuc-Van, Do, Phuong-Thi, Le, Hoai-Thi, Nguyen, Chi-Van, Nguyen, Phuong-Doan, Mai, Ton-Duy, Dao, Phuong-Viet, Nguyen, Dung-Tien, Khuong, Dai-Quoc, Vuong, Trung-Xuan, Vu, Lan-Tuong, Ngo, Ngoc-Duc, Dang, Hanh-Hong, Truong, Phuong-Thai, Le, Ngan-Thi, Hoang, Hoa-Van, Do, Chung-Quang, Nguyen, Minh-Thao, Dam, Anh-Hai, Le, Quynh-Nhu, Nguyen, Ngoc-Hoang, Nguyen, Tuyen-Van, Le, Toan-Dinh, Dinh, Ha-Thi Hai, Pham, Cuong-Van, Thach, Khanh-Thi Ngoc, Nguyen, Linh-Hai, Nguyen, Loan-Thi, Le, Vien-Chi, Tran, Phuong-Hong, Nguyen, Tai-Anh, Le, Tuan-Van, Truong, Luyen-Van, Bui, Tue-Chau, Huynh, Ngoc-Xuan, Dinh, Lap-Van, Pham, An-Gia, Le, Trang-Thi Huyen, Nguyen, Vy-Tuong, Nguyen, Yen-Hai, Nguyen, Thang-Ba, Thai, Huy, Pham, Quyen-Thi Ngoc, Dao, Khoa-Duy, Pham, Quoc-Nguyen Bao, Dang, Thuong-Thi Huyen, Dinh, Huong-Huynh To, Tong, Trang-Mai, Vu, Thuy-Thi, Le, Si-Tri, Tran, Tai-Ngoc, Tran, Phuong-Hoai, Dinh, Ngoc-Thuy Nhu, Nguyen, Binh-Thanh, Do, Vinh-Phuong, Nguyen, Anh-Ngoc, Nguyen, Binh-Thi Thanh, Blacker, David, Bunce, Lindsey, Tan, Ai Ling, Ghia, Darshan, Edmonds, Gillian, O'Loughlin, Nicole, Ewing, Megan, Whittaker, Kerri-Ann, Deane, Lorralee, Gawarikar, Yash, Jones, Brett, Lopez, Maria, Nagesh, Koushik, Siracusa, Emma, Davis, Stephen, McDonald, Amy, Tsoleridis, Jess, McCoy, Rachael, Jackson, David, Silver, Gab, Bates, Timothy R., Boudville, Amanda, Southwell, Lynda, Cordato, Dennis, McDougall, Alan J., Cappelen-Smith, Cecilia, Calic, Zeljka, Askar, Shabeel, Cheng, Qi, Kumar, Raymond, Geraghty, Richard, Duroux, Maree, Ratcliffe, Megan, Shone, Samantha, McLennan, Cassandra, Sahathevan, Ramesh, Hair, Casey, Levy, Stanley, Macdonald, Beverley, Nham, Benjamin, Rigney, Louise, Nathani, Dev, Gopinath, Sumana, Patel, Vishal, Mamun, Abul, Trewin, Benjamin, Phua, Chun, Choong, Ho, Tarrant, Lauren, Boyle, Kerry, Hewitt, Luisa, Hourn, Monique, Masterson, Amanda, Oakley, Kim, Ruddell, Karen, Sanctuary, Colette, Veitch, Kimberley, Burdusel, Camelia, Lee, Lina, Cheuk, Gary, Christley, Jeremy, Hartwell, Tabitha, Davenport, Craig, Hickey, Kate, Robertson, Rosanna, Carr, Michelle, Akbari, Sam, Coyle, Hannah, O'Neill, Megan, Redpath, Cameron, Roberts, Caroline, Tabesh, Marjan, Withiel, Toni, Abeysuriya, Kapila, Granger, Andrew, Abraham, Angela, Chua, Chermaine, Do Nguyen, Dung, Surendran, Vathani, Daines, Melissa, Shivlal, David, Latif, Mudassar, Mughal, Noreen, Morgan, Patricia, Krause, Martin, Priglinger, Miriam, Shandiz, Ehsan E., Day, Susan, Kho, Lay, Pollack, Michael, Dunne, Judith, Baines, Helen, Rees, Merridie, White, Jenni, Withanage, Aicuratiya, Delcourt, Candice, Carcel, Cheryl, Malavera, Alejandra, Kunchok, Amy, Ray, Elizabeth, Pepper, Elizabeth, Duckett, Emily, Ormond, Sally, Moey, Andrew, Kleinig, Timothy, Maxwell, Vanessa, Baldwin, Chantal, Vallat, Wilson, Field, Deborah, Markus, Romesh, Page, Kirsty, Wheelwright, Danielle, Bolitho, Sam, Faux, Steven, Sangvatanakul, Fix, Brown, Alexis, Walker, Susan, Massey, Jennifer, Hayes, Hillary, Katrak, Pesi, Winker, Annie, Zagami, Alessandro, Bailey, Alanah, Mccormack, Sarah, Murray, Andrew, Rollason, Mark, Taylor, Christopher, O'Rourke, Fintan, Kuang, Ye Min, Burnet, Heike, Liu, Yvonne, Wu, Aileen, Ramirez, Diana, Wijeratne, Tissa, Celestino, Sherisse, Low, Essie, Chen, Cynthia, Bergqvist, Jennifer, Evans, Andrew, Leung, Queenie, Jude, Martin, McQueen, Rachael, Mohr, Katherine, Kernaghan, Latitia, Stockle, Paul, Tan, Boon L., Laubscher, Sara, Schmid, Diana, Spooner, Melissa, Lallu, Bhavesh, Pepperell, Bronwen, Chalissery, John, Mahawish, Karim, DeCaigney, Susan, Broughton, Paula, Knight, Karen, Duque, Veronica, McNaughton, Harry, Lanford, Jeremy, Fu, Vivian, and Wong, Lai-Kin

Published
2020
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23. The main Optimal Post rTpa-Iv Monitoring in Ischemic Stroke Trial (OPTIMISTmain): protocol for a pragmatic, stepped wedge, cluster randomized controlled trial

Author

Ouyang, Menglu, primary, Faigle, Roland, additional, Wang, Xia, additional, Johnson, Brenda, additional, Summers, Debbie, additional, Khatri, Pooja, additional, Billot, Laurent, additional, Liu, Hueiming, additional, Malavera, Alejandra, additional, Munoz-Venturelli, Paula, additional, Gonzalez, Francisca, additional, Urrutia, Francisca, additional, Day, Diana, additional, Song, Lili, additional, Sui, Yi, additional, Delcourt, Candice, additional, Robinson, Thompson, additional, Durham, Alice C., additional, Ebraimo, Ahtasam, additional, Wan Zaidi, Wan Asyraf, additional, Jan, Stephen, additional, Lindley, Richard I., additional, Urrutia, Victor C., additional, and Anderson, Craig S., additional

Published
2023
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26. Genetic diversity and population structure of Saccharum hybrids

Author

Perera, María Francisca, primary, Ostengo, Santiago, additional, Malavera, Andrea Natalia Peña, additional, Balsalobre, Thiago Willian Almeida, additional, Onorato, Guilherme Dias, additional, Noguera, Aldo Sergio, additional, Hoffmann, Hermann Paulo, additional, and Carneiro, Monalisa Sampaio, additional

Published
2023
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27. Baseline brain imaging signs in patients with ischaemic stroke by the presence of atrial fibrillation: the ENCHANTED trial

Author

Xia Wang, Shoujiang You, Zien Zhou, Candice Delcourt, Joanna Wardlaw, Grant Mair, Thompson Robinson, Xiaoying Chen, Sohei Yoshimura, Takako Torii-Yoshimura, Cheryl Carcel, Alejandra Malavera, Craig Anderson, and Richard I. Lindley

Subjects
Neurology, Neurology (clinical)
Abstract

Background We aimed to assess the association of atrial fibrillation (AF) on outcomes in a post hoc analysis of the ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study) and how this association is modified by baseline imaging features. Methods Inverse probability of treatment weight was used to remove baseline imbalances between those with and without AF. The primary outcome was the modified Rankin Scale (mRS) scores at 90 days. Secondary outcomes were symptomatic intracerebral haemorrhage (sICH), early neurological deterioration or death within 24 h, and death at 90 days. The logistic regression model was used to determine the associations. Results Of the 3285 patients included in this analysis, 636 (19%) had AF at baseline. Compared with non-AF, AF was not significantly associated with an unfavourable shift of mRS (odds ratio 1.09; 95% confidence interval, 0.96–1.24), but with sICH (2.82; 1.78-4.48; IST-3 criteria), early neurological deterioration or death within 24 h (1.31; 1.01-1.70), and death (1.42; 1.12-1.79). Among patients with acute ischaemic signs (presence, extent, swelling and attenuation of acute lesions), AF was associated with the increased risk of all the poor outcomes (all P Conclusions We found AF increased risk of sICH, early neurological deterioration or death and death, but not unfavourable functional recovery at day 90 after thrombolysis in patients with AIS. The presence of acute ischaemic brain imaging signs at stroke presentation could be used to improve risk stratification in the presence of AF. Trial registration The trial is registered at ClinicalTrials.gov (NCT01422616).

Published
2023

30. Screening for Fabry Disease in Young Strokes in the Australian Stroke Clinical Registry (AuSCR)

Author

Alejandra Malavera, Dominique A. Cadilhac, Vincent Thijs, Joyce Y. Lim, Brenda Grabsch, Sibilah Breen, Stephen Jan, and Craig S. Anderson

Subjects
fabry disease, α-galactosidase A, screening, blood spot test, GLA gene, young stroke, Neurology. Diseases of the nervous system, RC346-429
Abstract

Introduction: Fabry disease (FD) is an X-linked lysosomal storage disorder characterized by a deficiency or absence of alpha-galactosidase A (α-GAL A) enzyme, where stroke can be a serious complication. The aim of this study is to determine the feasibility of centralized screening for FD, among young stroke adults registered in the national Australian Stroke Clinical Registry (AuSCR).Methods: The study was conducted in young (age 18 – 55 years) survivors of acute stroke of unknown etiology registered in AuSCR at hospitals in Queensland, Tasmania, New South Wales, and Victoria during 2014 – 2015; and who, at the 3-month outcome assessment, agreed to be re-contacted for future research. Descriptive analyses of case identification from responses and specific enzyme and DNA sequencing analyses were conducted for α-galactosidase A (α-GLA) from dried blood spot (DBS) testing.Results: Of 326 AuSCR-identified patients invited to participate, 58 (18%) provided consent but six were subsequently unable to provide a blood sample and two later withdrew consent to use their data. Among the remaining 50 participants (median age 53 years [48 – 56 years]; 47% female), 67% had experienced an acute ischemic stroke. All males (n = 27) had an initial screen for α-GLA enzyme activity of whom seven with low enzyme levels had normal secondary α-GLA gene analysis. All females (n = 23) had genetic analysis, with one shown to have a pathogenic c.352C>T p.(Arg118Cys) missense mutation of the α-GLA gene for FD.Conclusions: These findings provide logistical data for embedding a process of automated central stroke registry screening for an additional case-finding tool in FD.

Published
2020
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31. Interaction between potyvirus and crinivirus in sweet potato

Author

Sofía Solange Flamarique, Antonella Vilanova Perez, Andrea Peña Malavera, Julia Martino, and Liliana Di Feo

Subjects
ipomoea batatas, spfmv, spvg, spcsv, virus concentration, Agriculture (General), S1-972
Abstract

Sweet potato, in Argentina, is affected by the “encrespamiento amarillo”, a viral disease in which seven viruses are involved, among them two potyvirus (sweet potato feathery mottle virus - SPFMV and sweet potato virus G - SPVG) and a crinivirus (sweet potato chlorotic stunt virus - SPCSV). This research aimed to study the interaction between SPFMV and SPVG with SPCSV in sweet potato. Two sweet potato cultivars (Gem and Arapey INIA) and Ipomoea setosa as an indicator susceptible plant were tested as single (SPFMV or SPVG), double (SPFMV + SPVG, SPFMV + SPCSV or SPVG + SPCSV) or triple (SPFMV + SPVG + SPCSV) grafts. Both potyviruses were purified and the viral concentrations in the plant tissues were quantified by the DAS-Elisa method. The viruses and their severities were evaluated at 7, 15, 21, 30 and 35 days post-inoculation. A synergistic effect was observed with the three viruses in the indicator plant. The viral concentration increase was 50 times for SPFMV (day 35) and two times for SPVG (day 21) in the Gem cultivar, and 1.89 times for SPFMV (day 35) and three times for SPVG (day 7) in the Arapey INIA. For multiple infections, the indicator plant and the Gem cultivar exhibited synergistic symptoms and increase in the viral titers, with a higher severity and variability of the symptoms. Co-infections such as SPFMV + SPVG showed characteristic potyvirus symptoms, without increasing the viral concentrations; triple co-infections exhibited viral complex symptoms, with increase in the potyvirus titers; and the symptoms were mild or imperceptible in the simple infections.

Published
2020
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32. The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial

Author

Ma, Lu, primary, Hu, Xin, additional, Song, Lili, additional, Chen, Xiaoying, additional, Ouyang, Menglu, additional, Billot, Laurent, additional, Li, Qiang, additional, Malavera, Alejandra, additional, Li, Xi, additional, Muñoz-Venturelli, Paula, additional, de Silva, Asita, additional, Thang, Nguyen Huy, additional, Wahab, Kolawole W, additional, Pandian, Jeyaraj D, additional, Wasay, Mohammad, additional, Pontes-Neto, Octavio M, additional, Abanto, Carlos, additional, Arauz, Antonio, additional, Shi, Haiping, additional, Tang, Guanghai, additional, Zhu, Sheng, additional, She, Xiaochun, additional, Liu, Leibo, additional, Sakamoto, Yuki, additional, You, Shoujiang, additional, Han, Qiao, additional, Crutzen, Bernard, additional, Cheung, Emily, additional, Li, Yunke, additional, Wang, Xia, additional, Chen, Chen, additional, Liu, Feifeng, additional, Zhao, Yang, additional, Li, Hao, additional, Liu, Yi, additional, Jiang, Yan, additional, Chen, Lei, additional, Wu, Bo, additional, Liu, Ming, additional, Xu, Jianguo, additional, You, Chao, additional, Anderson, Craig S, additional, Robinson, Thompson, additional, Miranda, J. Jaime, additional, Anderson, Craig S., additional, Parry-Jones, Adrian, additional, Sprigg, Nikola, additional, Durrans, Sophie, additional, Harris, Caroline, additional, Bamford, Ann, additional, Smith, Olivia, additional, Herbert, Robert, additional, Chen, Christopher, additional, Whiteley, William, additional, Hu, Rong, additional, Mysore, Jayanthi, additional, Zhang, Yao, additional, Jan, Stephen, additional, Liu, Hueiming, additional, Sun, Lingli, additional, Chu, Honglin, additional, Anjum, Anila, additional, Gonzalez Mc Cawley, Francisca, additional, Del Rio, Alejandra, additional, Rimoli, Bruna, additional, Cerantola, Rodrigo, additional, Jeevarajah, Thanushanthan, additional, Kannangara, Madhushani, additional, Joseph, Andrene, additional, Nanayakkara, Chamath, additional, Zhang, Chunmiao, additional, Yang, Zhao, additional, Li, Brook, additional, Meng, Zhuo, additional, Ning, Yi, additional, Dong, Le, additional, Armenis, Manuela, additional, Lim, Joyce, additional, Monaghan, Helen, additional, Ma, Lu, additional, Luo, Rui, additional, Cheng, Guojuan, additional, Dong, Yilin, additional, Liu, Ziqin, additional, Wang, Shuihong, additional, Zhang, Ying, additional, Cheng, Jipeng, additional, Shi, Hui, additional, Li, Wenjing, additional, Mou, Langming, additional, Yi, Ping, additional, Chen, Xue, additional, Weerawardena, Shalomi, additional, Ellawala, Poornima, additional, Ranasinghe, Enalee, additional, Rodrigo, Chrishmi, additional, Wahab, Kolawala, additional, Adeniyi, Sunday, additional, Pandian, Jeyaraj, additional, Khanna, Megha, additional, Muñoz Venturelli, Paula, additional, González, Francisca, additional, Urrutia Goldsack, Francisca, additional, Begum, Dilshad, additional, Pontes-Neto, Octavio, additional, Camilo, Millene, additional, Dias, Francisco, additional, Vincenzi, Octavio, additional, Moro, Carla, additional, Santos, Renata, additional, Texeira, Nara, additional, Longo, Alexandre, additional, Liberato, Rafaela, additional, Martins, Sheila, additional, Pille, Arthur, additional, Chwal, Bruna, additional, Silva, Isabel, additional, Titton, Natacha, additional, Weiss, Gustavo, additional, Mora, Daissy, additional, Ouriques, Magda, additional, Carbonera, Leonardo, additional, Bazan, Rodrigo, additional, Modolo, Gabriel, additional, Winckler, Fernanda, additional, Miranda, Luana, additional, Souza, Juli, additional, Rojo, Alexis, additional, Uslar, Wilhelm, additional, Medel, Lorena, additional, Lopez, Javiera, additional, Herrero, Diego, additional, Lavados, Pablo, additional, Vargas Latorre, Barbara, additional, Conejan, Nathalie, additional, Esparza, Tomas, additional, Sotomayor, Patricio, additional, Wenger, Denisse, additional, Gigoux, Juan Pablo, additional, Letelier, Aldo, additional, Acevedo, Lilian, additional, Moya, Vivianne, additional, Figueroa, Cristian, additional, Vallejos, Nicol, additional, Guerrero, Rodrigo, additional, Velasquez, Mauricio, additional, Vallejos, Jose, additional, Pallauta, Kimerly, additional, Santibanez, Tamara, additional, Queirolo, Angelo, additional, Lobos, Andrea, additional, Jiang, Yongming, additional, Li, Weimin, additional, Huang, Wei, additional, Luo, Ke, additional, Liu, Gangying, additional, Yang, Guang, additional, Jiang, Hongtao, additional, Zhang, Xu, additional, Jing, Hongyan, additional, Pu, Bo, additional, Lv, Dong, additional, Kang, Hui, additional, Hu, Qiuping, additional, Jiang, Xiaoming, additional, Chen, Yanli, additional, Yang, Shenghua, additional, He, Jianjun, additional, Li, Zongping, additional, Cheng, Gang, additional, Huang, Hailin, additional, Wang, Xiaoyi, additional, Lin, Jianqiong, additional, Chen, Minhui, additional, Yang, Chenghao, additional, Ding, Hao, additional, Deng, Yunliang, additional, Luo, Fei, additional, Zhang, Rongjun, additional, Wang, Xiaofeng, additional, Zhang, Hongbing, additional, Yang, Xiaoliang, additional, Zhang, Yang, additional, Yang, Chengyi, additional, He, Yu, additional, Liu, Feng, additional, Wang, Rongjie, additional, Zhang, Yuhui, additional, Xin, Xiaodong, additional, Feng, Bin, additional, Hao, Wanru, additional, Song, Chang, additional, Guo, Yun, additional, Jiang, Dehua, additional, Chen, Jie, additional, Tang, Changtong, additional, Zhu, Hongliang, additional, Li, Xin, additional, Cui, Jin, additional, Xu, Haidong, additional, Li, Boyang, additional, Tang, Fusheng, additional, Li, Yuanbin, additional, Gao, Min, additional, Yang, Bo, additional, Xu, Xuejun, additional, Deng, Bing, additional, Zheng, Yi, additional, Ge, Yuanhong, additional, Chen, Keyu, additional, Liu, Yang, additional, Li, Xinshen, additional, Zhong, Tingting, additional, Xu, Jianfeng, additional, Zhang, Hai, additional, Wang, Jiyue, additional, Zhu, Jianxin, additional, Sun, Hanyu, additional, Yu, Fuhua, additional, Zhang, Xueguang, additional, Zhang, Mingsen, additional, Wang, Bin, additional, Ma, Yiming, additional, Jiang, Donglin, additional, Zhou, Jun, additional, Liu, Cong, additional, Nie, Wenhong, additional, Li, Mingguo, additional, Tian, Tao, additional, Li, Yong, additional, He, Mingfang, additional, Tu, Xiaolong, additional, Wu, Zhengjun, additional, Liu, Hong, additional, Zhong, Dongsheng, additional, Jiang, Rongcai, additional, Sun, Jian, additional, Tian, Ye, additional, Wei, Yingsheng, additional, An, Shuo, additional, Wei, Pingbo, additional, Luo, Le, additional, Lin, Bin, additional, Liu, Gang, additional, Wen, Yan, additional, Cai, Qiang, additional, Chen, Qianxue, additional, Lei, Pan, additional, Li, Zhiyang, additional, Zhang, Meifang, additional, He, Jiaquan, additional, Chen, Yan, additional, Liu, Jun, additional, Liu, Xinghai, additional, Li, Junyan, additional, Chen, Min, additional, Wang, Jing, additional, Zhou, Bingzhi, additional, Ye, Baichun, additional, Zhang, Jiancheng, additional, Zhang, Manyuan, additional, Pan, Xuming, additional, Yu, Xiaoxiang, additional, Xu, Jian, additional, Xiao, Qingbao, additional, Wang, Yuefei, additional, Tao, Liang, additional, Shi, Lin, additional, Zheng, Niandong, additional, You, Guoliang, additional, Lei, Bo, additional, Chen, Shu, additional, Wu, Honggang, additional, Hu, Jin, additional, Zhao, Jianlan, additional, Yu, Jian, additional, Yuan, Qiang, additional, Du, Zhuoying, additional, Tang, Xielin, additional, Li, Qianke, additional, Liu, Shenghua, additional, Yang, Feilong, additional, Xiao, Kui, additional, Luo, Chao, additional, Wang, Guang, additional, Che, Xudong, additional, Teng, Zhipeng, additional, Wan, Wenwu, additional, Li, Jun, additional, Liu, Yu, additional, Fan, Mingbo, additional, Zhang, Tao, additional, Cai, Lun, additional, Ma, Yuan, additional, Ma, Zhifeng, additional, Li, Bin, additional, He, Linlin, additional, Li, Jinghui, additional, Zhang, Weibing, additional, Zhang, Shuxin, additional, Zhang, Hongzhen, additional, Dai, Yingguang, additional, Lei, Jun, additional, Mao, Lei, additional, Huang, Yiyang, additional, Zhou, Zhi, additional, Chen, Ping, additional, Chen, Fang, additional, Wei, Pan, additional, Li, Tiangui, additional, Chen, Honglin, additional, Zeng, Mengfei, additional, Mou, Kejie, additional, Xue, Jun, additional, Jiang, Yong, additional, Tang, Xiaoping, additional, Chen, Tao, additional, Zhang, Yalan, additional, Xu, Yanbing, additional, Gu, Yuchen, additional, Zhao, Yujun, additional, Yang, Bin, additional, Kuai, Peng, additional, Wang, Xi, additional, Yang, Yuwang, additional, Hu, Xueling, additional, Zhang, Huitian, additional, Yang, Yintao, additional, Wang, Weifeng, additional, Zhang, Junyi, additional, Cheng, Wei, additional, Zhang, Xiaoxue, additional, Ma, Xiaowen, additional, He, Qin, additional, Zhang, Li, additional, Gao, Rong, additional, Liu, Huixiang, additional, Ye, Jingwei, additional, Xu, Ping, additional, Wu, Xin, additional, Yuan, Yuan, additional, Zou, Peng, additional, Zhang, Zhen, additional, Cheng, Jiyong, additional, Zhou, Zhangming, additional, Zeng, Yijun, additional, Liang, Zhang, additional, Du, Deming, additional, Yu, Shui, additional, Cao, Yongjun, additional, Xu, Jiaping, additional, Huang, Zhichao, additional, Chen, Dongqin, additional, Xiao, Wenfeng, additional, Zhu, Li, additional, Yuan, Miao, additional, Wang, Yuhai, additional, Shi, Dongliang, additional, Hu, Xu, additional, Xiang, Dingchao, additional, Shi, Like, additional, Wang, Hongqin, additional, Yang, Liu, additional, Miao, Wang, additional, Hu, Yiyi, additional, Zhao, Yuchun, additional, Hu, Xi, additional, Zhou, Weiduo, additional, Sun, Chao, additional, Tang, Dong, additional, Yao, Kun, additional, You, Jin, additional, Chen, Shishi, additional, Yao, Jianmin, additional, Li, Huanmei, additional, Liu, Jinmei, additional, Bai, Ailin, additional, Yi, Yong, additional, Deng, Qingshan, additional, Luo, Peng, additional, Wang, Han, additional, Jiang, Jingcheng, additional, Yang, Qingwei, additional, He, Shunpo, additional, Wang, Jun, additional, Chen, Yu, additional, He, Hua, additional, Deng, Yuyang, additional, Cao, Zhikai, additional, Yi, Xuxia, additional, Luo, Jinbiao, additional, Luo, Shuang, additional, Gong, Min, additional, Liu, Li, additional, Gao, Xuejun, additional, Liu, Jia, additional, Wu, Li'e, additional, Zhang, Jia, additional, Sun, Hongying, additional, Li, Xinhui, additional, Jia, Lu, additional, Wu, Jianbing, additional, Zhang, Jie, additional, Zhang, Huajun, additional, Du, Chunfu, additional, Li, Shun, additional, Yang, Xiaobin, additional, He, Jie, additional, Liao, Lei, additional, Zhou, Gezhi, additional, Dong, Wentao, additional, Chen, Yunxiang, additional, Lin, Xiaofeng, additional, Shui, Xujian, additional, Zhang, Peng, additional, Zhao, Yuan, additional, Yang, Hongli, additional, Zhao, Wenbin, additional, Zhang, Xiaoyi, additional, Chen, Jincao, additional, Wu, Qian, additional, Dai, Xuan, additional, Tang, Baogui, additional, Wang, Yinjuan, additional, Liu, Tao, additional, Zhang, Haixia, additional, Duan, Faliang, additional, Luo, Ming, additional, Jiao, Qingfang, additional, Lei, Guoliang, additional, Wang, Dong, additional, Song, Chunwang, additional, Tan, Haopeng, additional, Ye, Feng, additional, Qin, Xinghu, additional, Liang, Xiaolong, additional, Liu, Junling, additional, Yang, Lang, additional, Yang, Jie, additional, Lin, Yapeng, additional, Yang, Qian, additional, Ma, Xuntai, additional, Qi, Yinkuang, additional, Pan, Baogen, additional, Jiang, Caixia, additional, Ye, Zhanying, additional, Dong, Ce, additional, Yue, Xiongfei, additional, Yang, Xiaopeng, additional, Maimaitiyiming, Tuoheti, additional, Dong, Jun, additional, Wu, Yonggang, additional, Gao, Feng, additional, Zhao, Deqiang, additional, Zhang, Xinghai, additional, Wang, PengJun, additional, Jiang, Hongbo, additional, Li, Jianping, additional, Zhang, Wei, additional, Chen, Jing, additional, Tong, Haibo, additional, Wang, Yonghong, additional, Qiao, Kaipeng, additional, Guo, Fuyou, additional, Zhang, Mingchu, additional, Hu, Yan, additional, Feng, Mengzhao, additional, Song, Dengpan, additional, Zuo, Yi, additional, Chen, Shangjun, additional, Qian, Chao, additional, Li, Baoming, additional, Ma, Jingku, additional, Zhang, Sunfu, additional, Kong, Bin, additional, Dong, Xingyu, additional, Fang, Sheng, additional, Lu, Bin, additional, Li, Yang, additional, Yang, Yongling, additional, Yu, Hong, additional, Sun, Huaiyu, additional, Wang, Yue, additional, Wang, Weimin, additional, Li, Tong, additional, Li, Shengli, additional, Xu, Zhiming, additional, Wang, Yongyi, additional, Dong, Qiang, additional, Tang, Yuping, additional, Chu, Heling, additional, Lu, Ying, additional, Wang, Zhong, additional, Sun, Xiaoou, additional, Zhao, Jianhua, additional, Yang, Shuaifeng, additional, Qian, Xiying, additional, Saroja, Aralikatte Onkarappa, additional, Naik k, Ravishankar, additional, Chindhi, Sandip, additional, Pampaniya, Nakul, additional, Amaresh, Kurubara, additional, Iype, Thomas, additional, R, Dileep, additional, Rajan, Reeja, additional, Panicker, Praveen, additional, Das, Rupjyoti, additional, Choudhury, Nupur, additional, Gohain, Pankaja, additional, Webster, Jemin, additional, Pakma, Biyol, additional, Sangi, Lalbiak, additional, Sebastian, Ivy, additional, Aggrawal, Gaurav, additional, Raj, Komal, additional, Rajoura, Deepankshi, additional, Singh, Sulena, additional, Aggrawal, Varun, additional, Narang, Amit, additional, Cano-Nigenda, Vanesa, additional, López-Mena, Diego, additional, Valdez-Ruvalcaba, Héctor, additional, Toledo-Treviño, Roberto, additional, Obiako, Reginald, additional, Abubakar, Sani, additional, Emeka, Oguike, additional, Olayemi, Balogun, additional, Lois, Melika, additional, Philip, Ibinaiye, additional, Comfort O, Olurishe, additional, Okubadejo, Njideka, additional, Agabi, Osigwe, additional, Ojo, Oluwadamilola, additional, Wahab, Kolawole, additional, Bello, Abiodun, additional, Ibukun, Oyinloye, additional, Sanayaolu, Olufemi, additional, Jimoh, Abdulraheem, additional, Waheed, Shahid, additional, Kamal, Dr.Ayeesha, additional, Shoaib, Raja Farhat, additional, Orooj, Fizza, additional, Majid, Sadaf, additional, Zehra, Taskeen, additional, Khan, Abdus Salam, additional, Shanker, Ravi, additional, Syed, Nadir Ali, additional, Ahmad, Nashwa, additional, Valencia, Ana, additional, Barrientos, Danny, additional, Ramirez, Jorge, additional, Calle, Pilar, additional, Palliyeguruge, Dilum, additional, Muthucumarana, Sumudu, additional, Ratnayaka, Shiroma, additional, Ganihiarachchi, Dilhara, additional, Bandaranayake, Arundathi, additional, Somaratne, S.D.B, additional, Narayana, Saumya, additional, Gallage, Sithara, additional, Senanayake, Bimsara, additional, Samarasiri, Udari, additional, Luke, Dunya, additional, Sivapathasundaram, Mythily, additional, Sahadevan, Vithoosan, additional, Rasmi, Amani, additional, Deshaka, Yuran, additional, Fernando, Nilukshi, additional, Munasinghe, Aruna, additional, Rathnapriya, Kapilanga, additional, Nissanka, A.S, additional, Karunathilake, Kanchana, additional, Gayan, Isuru, additional, Wijenayake, Kaminda, additional, Gunasekara, Hasitha, additional, Vidyarathne, Jagath, additional, Keshavaraj, Ajantha, additional, Janarthanan, Kanagasabapathy, additional, Gerald Jeevathasan, Arhivalaky, additional, Sivamainthan, Sivaram, additional, John Priyanth, Mathyamuthan, additional, John Priyanth, Abirami, additional, Rajendiran, Thambippillai, additional, Alwis, Sanjeewa, additional, Gunasekare, Nushara, additional, Liyanarachchi, Vasundara, additional, Dissanayake, Athula, additional, Uluwattage, Wimalasiri Mewa, additional, Ratnayake, Gimhani, additional, Rajinee, Charika, additional, Jayawardana, Sakura, additional, Peiris, Janaka, additional, Wicramasinghe, Ranjith, additional, Fernando, Chamila, additional, Abbas, Jessie, additional, Withanage, Nethmini, additional, Bandara, Makaranda, additional, Mai, Duy Ton, additional, Nguyen, Van Chi, additional, Dao, Viet Phuong, additional, Vuong, Xuan Trung, additional, Nguyen, Tien Dung, additional, Dinh, Trung Hieu, additional, Phan, Ha Quan, additional, Bui, Quoc Viet, additional, Phung, Dinh Tho, additional, Pham, Quang Tho, additional, Pham, Dinh Dai, additional, Do, Duc Thuan, additional, Dang, Phuc Duc, additional, Dang, Minh Duc, additional, Nguyen, Dang Hai, additional, Nguyen, Thi Phuong Nga, additional, Nguyen, Quoc Huy, additional, Pham, Quoc Dai, additional, Chau, Quoc Vinh, additional, Tai, Vinh Thy Van, additional, Le, Tran Vinh, additional, Le, Cong Tri, additional, Tran, Ha Mai Khuong, additional, Nguyen, Huu Khanh, additional, Ngyen, Hoang Minh Thao, additional, Vo, Duc Chien, additional, Nguyen, Thai My Phuong, additional, Tran, Trung Thanh, additional, Vo, Thi Hanh Vi, additional, Cao, Hao Nhien, additional, Nguyen, Ba Thang, additional, Le, Thi Ngoc Suong, additional, La, Thien Duc, additional, Pham, Chi Duc, additional, and Thai, Huy, additional

Published
2023
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34. Novel alleles linked to brown rust resistance in sugarcane

Author

Solana Chaves, Santiago Ostengo, Romina Priscila Bertani, Andrea Natalia Peña Malavera, María Inés Cuenya, María Paula Filippone, Atilio Pedro Castagnaro, Mónica Graciela Balzarini, and Josefina Racedo

Subjects
Genetics, Plant Science, Horticulture, Agronomy and Crop Science
Published
2022

35. The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial

Author

Lu Ma, Xin Hu, Lili Song, Xiaoying Chen, Menglu Ouyang, Laurent Billot, Qiang Li, Alejandra Malavera, Xi Li, Paula Muñoz-Venturelli, Asita de Silva, Nguyen Huy Thang, Kolawole W Wahab, Jeyaraj D Pandian, Mohammad Wasay, Octavio M Pontes-Neto, Carlos Abanto, Antonio Arauz, Haiping Shi, Guanghai Tang, Sheng Zhu, Xiaochun She, Leibo Liu, Yuki Sakamoto, Shoujiang You, Qiao Han, Bernard Crutzen, Emily Cheung, Yunke Li, Xia Wang, Chen Chen, Feifeng Liu, Yang Zhao, Hao Li, Yi Liu, Yan Jiang, Lei Chen, Bo Wu, Ming Liu, Jianguo Xu, Chao You, Craig S Anderson, Thompson Robinson, J. Jaime Miranda, Craig S. Anderson, Adrian Parry-Jones, Nikola Sprigg, Sophie Durrans, Caroline Harris, Ann Bamford, Olivia Smith, Robert Herbert, Christopher Chen, William Whiteley, Rong Hu, Jayanthi Mysore, Yao Zhang, Stephen Jan, Hueiming Liu, Lingli Sun, Honglin Chu, Anila Anjum, Francisca Gonzalez Mc Cawley, Alejandra Del Rio, Bruna Rimoli, Rodrigo Cerantola, Thanushanthan Jeevarajah, Madhushani Kannangara, Andrene Joseph, Chamath Nanayakkara, Chunmiao Zhang, Zhao Yang, Brook Li, Zhuo Meng, Yi Ning, Le Dong, Manuela Armenis, Joyce Lim, Helen Monaghan, Rui Luo, Guojuan Cheng, Yilin Dong, Ziqin Liu, Shuihong Wang, Ying Zhang, Jipeng Cheng, Hui Shi, Wenjing Li, Langming Mou, Ping Yi, Xue Chen, Shalomi Weerawardena, Poornima Ellawala, Enalee Ranasinghe, Chrishmi Rodrigo, Kolawala Wahab, Sunday Adeniyi, Jeyaraj Pandian, Megha Khanna, Paula Muñoz Venturelli, Francisca González, Francisca Urrutia Goldsack, Dilshad Begum, Octavio Pontes-Neto, Millene Camilo, Francisco Dias, Octavio Vincenzi, Carla Moro, Renata Santos, Nara Texeira, Alexandre Longo, Rafaela Liberato, Sheila Martins, Arthur Pille, Bruna Chwal, Isabel Silva, Natacha Titton, Gustavo Weiss, Daissy Mora, Magda Ouriques, Leonardo Carbonera, Rodrigo Bazan, Gabriel Modolo, Fernanda Winckler, Luana Miranda, Juli Souza, Alexis Rojo, Wilhelm Uslar, Lorena Medel, Javiera Lopez, Diego Herrero, Pablo Lavados, Barbara Vargas Latorre, Nathalie Conejan, Tomas Esparza, Patricio Sotomayor, Denisse Wenger, Juan Pablo Gigoux, Aldo Letelier, Lilian Acevedo, Vivianne Moya, Cristian Figueroa, Nicol Vallejos, Rodrigo Guerrero, Mauricio Velasquez, Jose Vallejos, Kimerly Pallauta, Tamara Santibanez, Angelo Queirolo, Andrea Lobos, Yongming Jiang, Weimin Li, Wei Huang, Ke Luo, Gangying Liu, Guang Yang, Hongtao Jiang, Xu Zhang, Hongyan Jing, Bo Pu, Dong Lv, Hui Kang, Qiuping Hu, Xiaoming Jiang, Yanli Chen, Shenghua Yang, Jianjun He, Zongping Li, Gang Cheng, Hailin Huang, Xiaoyi Wang, Jianqiong Lin, Minhui Chen, Chenghao Yang, Hao Ding, Yunliang Deng, Fei Luo, Rongjun Zhang, Xiaofeng Wang, Hongbing Zhang, Xiaoliang Yang, Yang Zhang, Chengyi Yang, Yu He, Feng Liu, Rongjie Wang, Yuhui Zhang, Xiaodong Xin, Bin Feng, Wanru Hao, Chang Song, Yun Guo, Dehua Jiang, Jie Chen, Changtong Tang, Hongliang Zhu, Xin Li, Jin Cui, Haidong Xu, Boyang Li, Fusheng Tang, Yuanbin Li, Min Gao, Bo Yang, Xuejun Xu, Bing Deng, Yi Zheng, Yuanhong Ge, Keyu Chen, Yang Liu, Xinshen Li, Tingting Zhong, Jianfeng Xu, Hai Zhang, Jiyue Wang, Jianxin Zhu, Hanyu Sun, Fuhua Yu, Xueguang Zhang, Mingsen Zhang, Bin Wang, Yiming Ma, Donglin Jiang, Jun Zhou, Cong Liu, Wenhong Nie, Mingguo Li, Tao Tian, Yong Li, Mingfang He, Xiaolong Tu, Zhengjun Wu, Hong Liu, Dongsheng Zhong, Rongcai Jiang, Jian Sun, Ye Tian, Yingsheng Wei, Shuo An, Pingbo Wei, Le Luo, Bin Lin, Gang Liu, Yan Wen, Qiang Cai, Qianxue Chen, Pan Lei, Zhiyang Li, Meifang Zhang, Jiaquan He, Yan Chen, Jun Liu, Xinghai Liu, Junyan Li, Min Chen, Jing Wang, Bingzhi Zhou, Baichun Ye, Jiancheng Zhang, Manyuan Zhang, Xuming Pan, Xiaoxiang Yu, Jian Xu, Qingbao Xiao, Yuefei Wang, Liang Tao, Lin Shi, Niandong Zheng, Guoliang You, Bo Lei, Shu Chen, Honggang Wu, Jin Hu, Jianlan Zhao, Jian Yu, Qiang Yuan, Zhuoying Du, Xielin Tang, Qianke Li, Shenghua Liu, Feilong Yang, Kui Xiao, Chao Luo, Guang Wang, Xudong Che, Zhipeng Teng, Wenwu Wan, Jun Li, Yu Liu, Mingbo Fan, Tao Zhang, Lun Cai, Yuan Ma, Zhifeng Ma, Bin Li, Linlin He, Jinghui Li, Weibing Zhang, Shuxin Zhang, Hongzhen Zhang, Yingguang Dai, Jun Lei, Lei Mao, Yiyang Huang, Zhi Zhou, Ping Chen, Fang Chen, Pan Wei, Tiangui Li, Honglin Chen, Mengfei Zeng, Kejie Mou, Jun Xue, Yong Jiang, Xiaoping Tang, Tao Chen, Yalan Zhang, Yanbing Xu, Yuchen Gu, Yujun Zhao, Bin Yang, Peng Kuai, Xi Wang, Yuwang Yang, Xueling Hu, Huitian Zhang, Yintao Yang, Weifeng Wang, Junyi Zhang, Wei Cheng, Xiaoxue Zhang, Xiaowen Ma, Qin He, Li Zhang, Rong Gao, Huixiang Liu, Jingwei Ye, Ping Xu, Xin Wu, Yuan Yuan, Peng Zou, Zhen Zhang, Jiyong Cheng, Zhangming Zhou, Yijun Zeng, Zhang Liang, Deming Du, Shui Yu, Yongjun Cao, Jiaping Xu, Zhichao Huang, Dongqin Chen, Wenfeng Xiao, Li Zhu, Miao Yuan, Yuhai Wang, Dongliang Shi, Xu Hu, Dingchao Xiang, Like Shi, Hongqin Wang, Liu Yang, Wang Miao, Yiyi Hu, Yuchun Zhao, Xi Hu, Weiduo Zhou, Chao Sun, Dong Tang, Kun Yao, Jin You, Shishi Chen, Jianmin Yao, Huanmei Li, Jinmei Liu, Ailin Bai, Yong Yi, Qingshan Deng, Peng Luo, Han Wang, Jingcheng Jiang, Qingwei Yang, Shunpo He, Jun Wang, Yu Chen, Hua He, Yuyang Deng, Zhikai Cao, Xuxia Yi, Jinbiao Luo, Shuang Luo, Min Gong, Li Liu, Xuejun Gao, Jia Liu, Li'e Wu, Jia Zhang, Hongying Sun, Xinhui Li, Lu Jia, Jianbing Wu, Jie Zhang, Huajun Zhang, Chunfu Du, Shun Li, Xiaobin Yang, Jie He, Lei Liao, Gezhi Zhou, Wentao Dong, Yunxiang Chen, Xiaofeng Lin, Xujian Shui, Peng Zhang, Yuan Zhao, Hongli Yang, Wenbin Zhao, Xiaoyi Zhang, Jincao Chen, Qian Wu, Xuan Dai, Baogui Tang, Yinjuan Wang, Tao Liu, Haixia Zhang, Faliang Duan, Ming Luo, Qingfang Jiao, Guoliang Lei, Dong Wang, Chunwang Song, Haopeng Tan, Feng Ye, Xinghu Qin, Xiaolong Liang, Junling Liu, Lang Yang, Jie Yang, Yapeng Lin, Qian Yang, Xuntai Ma, Yinkuang Qi, Baogen Pan, Caixia Jiang, Zhanying Ye, Ce Dong, Xiongfei Yue, Xiaopeng Yang, Tuoheti Maimaitiyiming, Jun Dong, Yonggang Wu, Feng Gao, Deqiang Zhao, Xinghai Zhang, PengJun Wang, Hongbo Jiang, Jianping Li, Wei Zhang, Jing Chen, Haibo Tong, Yonghong Wang, Kaipeng Qiao, Fuyou Guo, Mingchu Zhang, Yan Hu, Mengzhao Feng, Dengpan Song, Yi Zuo, Shangjun Chen, Chao Qian, Baoming Li, Jingku Ma, Sunfu Zhang, Bin Kong, Xingyu Dong, Sheng Fang, Bin Lu, Yang Li, Yongling Yang, Hong Yu, Huaiyu Sun, Yue Wang, Weimin Wang, Tong Li, Shengli Li, Zhiming Xu, Yongyi Wang, Qiang Dong, Yuping Tang, Heling Chu, Ying Lu, Zhong Wang, Xiaoou Sun, Jianhua Zhao, Shuaifeng Yang, Xiying Qian, Aralikatte Onkarappa Saroja, Ravishankar Naik k, Sandip Chindhi, Nakul Pampaniya, Kurubara Amaresh, Thomas Iype, Dileep R, Reeja Rajan, Praveen Panicker, Rupjyoti Das, Nupur Choudhury, Pankaja Gohain, Jemin Webster, Biyol Pakma, Lalbiak Sangi, Ivy Sebastian, Gaurav Aggrawal, Komal Raj, Deepankshi Rajoura, Sulena Singh, Varun Aggrawal, Amit Narang, Vanesa Cano-Nigenda, Diego López-Mena, Héctor Valdez-Ruvalcaba, Roberto Toledo-Treviño, Reginald Obiako, Sani Abubakar, Oguike Emeka, Balogun Olayemi, Melika Lois, Ibinaiye Philip, Olurishe Comfort O, Njideka Okubadejo, Osigwe Agabi, Oluwadamilola Ojo, Kolawole Wahab, Abiodun Bello, Oyinloye Ibukun, Olufemi Sanayaolu, Abdulraheem Jimoh, Shahid Waheed, Dr.Ayeesha Kamal, Raja Farhat Shoaib, Fizza Orooj, Sadaf Majid, Taskeen Zehra, Abdus Salam Khan, Ravi Shanker, Nadir Ali Syed, Nashwa Ahmad, Ana Valencia, Danny Barrientos, Jorge Ramirez, Pilar Calle, Dilum Palliyeguruge, Sumudu Muthucumarana, Shiroma Ratnayaka, Dilhara Ganihiarachchi, Arundathi Bandaranayake, S.D.B Somaratne, Saumya Narayana, Sithara Gallage, Bimsara Senanayake, Udari Samarasiri, Dunya Luke, Mythily Sivapathasundaram, Vithoosan Sahadevan, Amani Rasmi, Yuran Deshaka, Nilukshi Fernando, Aruna Munasinghe, Kapilanga Rathnapriya, A.S Nissanka, Kanchana Karunathilake, Isuru Gayan, Kaminda Wijenayake, Hasitha Gunasekara, Jagath Vidyarathne, Ajantha Keshavaraj, Kanagasabapathy Janarthanan, Arhivalaky Gerald Jeevathasan, Sivaram Sivamainthan, Mathyamuthan John Priyanth, Abirami John Priyanth, Thambippillai Rajendiran, Sanjeewa Alwis, Nushara Gunasekare, Vasundara Liyanarachchi, Athula Dissanayake, Wimalasiri Mewa Uluwattage, Gimhani Ratnayake, Charika Rajinee, Sakura Jayawardana, Janaka Peiris, Ranjith Wicramasinghe, Chamila Fernando, Jessie Abbas, Nethmini Withanage, Makaranda Bandara, Duy Ton Mai, Van Chi Nguyen, Viet Phuong Dao, Xuan Trung Vuong, Tien Dung Nguyen, Trung Hieu Dinh, Ha Quan Phan, Quoc Viet Bui, Dinh Tho Phung, Quang Tho Pham, Dinh Dai Pham, Duc Thuan Do, Phuc Duc Dang, Minh Duc Dang, Dang Hai Nguyen, Thi Phuong Nga Nguyen, Quoc Huy Nguyen, Quoc Dai Pham, Quoc Vinh Chau, Vinh Thy Van Tai, Tran Vinh Le, Cong Tri Le, Ha Mai Khuong Tran, Huu Khanh Nguyen, Hoang Minh Thao Ngyen, Duc Chien Vo, Thai My Phuong Nguyen, Trung Thanh Tran, Thi Hanh Vi Vo, Hao Nhien Cao, Ba Thang Nguyen, Thi Ngoc Suong Le, Thien Duc La, Chi Duc Pham, and Huy Thai

Subjects
General Medicine
Published
2023

37. Transformación tecnológica y digital en cooperativas en Antioquia

Author

Juan Santiago Calle-Piedrahita, Sandra Milena Malavera-Pineda, and Byron Enrique Portilla-Rosero Portilla-Rosero

Subjects
General Medicine
Abstract

Este artículo examina la dinámica innovadora en tecnología y trasformación digital de las cooperativas de Antioquia en la fase presente de globalización. Este análisis estuvo atravesado por la pandemia por Covid-19, es decir que aborda los elementos requeridos en las cooperativas para adaptarse a las exigencias de innovaciones tecnológicas y digitales durante épocas de crisis. La metodología utilizada fue cuantitativa a través de un cuestionario enviado electrónicamente a 801 gerentes de cooperativas durante el año 2020, y se obtuvo respuesta de 72 de ellos. De acuerdo a los hallazgos, se puede establecer que la hipótesis H1: el 0,70 de las cooperativas invierte en tecnología para mejorar el desempeño social, no se confirma; por eso, la hipótesis alterna es la pertinente. En conclusión, las cooperativas toman las decisiones de inversión en tecnología basadas en su funcionamiento interno (fidelización) y no en las necesidades de los clientes. Además, pocas entidades invirtieron en tecnología digital durante la crisis ocasionada por la Covid-19.

Published
2022

39. sj-pdf-1-cep-10.1177_03331024231183166 - Supplemental material for The effect of blood pressure lowering medications on the prevention of episodic migraine: A systematic review and meta-analysis

Author

Carcel, Cheryl, Haghdoost, Faraidoon, Shen, Joanne, Nanda, Puneet, Bai, Yu, Atkins, Emily, Torii-Yoshimura, Takako, Clough, Alexander J., Davies, Leo, Cordato, Dennis, Griffiths, Lyn R., Balicki, Grace, Wang, Xia, Vidyasagar, Kota, Malavera, Alejandra, Anderson, Craig S., Zagami, Alessandro S., Delcourt, Candice, and Rodgers, Anthony

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 110306 Endocrinology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-cep-10.1177_03331024231183166 for The effect of blood pressure lowering medications on the prevention of episodic migraine: A systematic review and meta-analysis by Cheryl Carcel, Faraidoon Haghdoost, Joanne Shen, Puneet Nanda, Yu Bai, Emily Atkins, Takako Torii-Yoshimura, Alexander J. Clough, Leo Davies, Dennis Cordato, Lyn R. Griffiths, Grace Balicki, Xia Wang, Kota Vidyasagar, Alejandra Malavera, Craig S. Anderson, Alessandro S. Zagami, Candice Delcourt and Anthony Rodgers in Cephalalgia

Published
2023
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40. Peripheral Neuropathy

Author

Stavale, Rafaelly, primary, Jones, Felipe, additional, Malavera, Alejandra, additional, and Fregni, Felipe, additional

Published
2018
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42. Process evaluation of complex interventions in non-communicable and neglected tropical diseases in low- and middle-income countries: a scoping review

Author

Maria, Lazo-Porras, Hueiming, Liu, Menglu, Ouyang, Xuejun, Yin, Alejandra, Malavera, Tiana, Bressan, Wilmer Cristobal, Guzman-Vilca, Niels, Pacheco, Melissa, Benito, J Jaime, Miranda, Graham, Moore, François, Chappuis, Pablo, Perel, and David, Beran

Subjects
Health Personnel, Humans, Developing Countries
Abstract

The aim of this review is to map out the use of process evaluation (PE) in complex interventions that address non-communicable diseases (NCDs) and neglected tropical diseases (NTDs) to identify gaps in the design and conduct, as well as strengths, limitations and implications, of this type of research in low- and middle-income countries (LMICs).Scoping review of PE studies of complex interventions implemented in LMICs. Six databases were searched focused on studies published since 2008.Embase, PubMed, EbscoHost, Web of Science (WOS), Virtual Health Library (VHL) Regional Portal and Global Index Medicus: Regional Indexes AIM (AFRO), LILACS (AMRO/PAHO), IMEMR (EMRO), IMSEAR (SEARO), WPRIM (WPRO) Global Index Regional Indexes, MEDLINE, SciELO.Studies conducted in LMICs on PEs of randomised controlled trials (RCTs) and non-RCTs published between January 2008 and January 2020. Other criteria were studies of interventions for people at risk or having physical and mental NCDs, and/or NTDs, and/or their healthcare providers and/or others related to achieve better health for these two disease groups. Studies were excluded if they were not reported in English or Spanish or Portuguese or French, not peer-reviewed articles, not empirical research and not human research.Data extracted to be evaluated were: available evidence in the utilisation of PE in the areas of NCDs and NTDs, including frameworks and theories used; methods applied to conduct PEs; and in a subsample, the barriers and facilitators to implement complex interventions identified through the PE. Variables were extracted and categorised. The information was synthesised through quantitative analysis by reporting frequencies and percentages. Qualitative analysis was also performed to understand facilitators and barriers presented in these studies. The implications for PEs, and how the information from the PE was used by researchers or other stakeholders were also assessed in this approach.303 studies were identified, 79% were for NCDs, 12% used the label 'PE', 27% described a theory or framework for the PE, and 42% used mixed methods to analyse their findings. Acceptability, barriers and facilitators to implement the interventions, experiences and perceptions, and feasibility were the outcomes most frequently evaluated as part of the PEs. Barriers and facilitators themes identified were contextual factors, health system factors, human resources, attitudes and policy factors.PEs in NCDs and NTDs are used in LMICs with a wide variety of methods. This review identified many PEs that were not labelled by the authors as such, as well as a limited application of PE-related theories and frameworks, and heterogeneous reporting of this type of study.

Published
2022

43. Cross-modal cueing effects of visuospatial attention on conscious somatosensory perception

Author

Deniz Doruk, Lorena Chanes, Alejandra Malavera, Lotfi B. Merabet, Antoni Valero-Cabré, and Felipe Fregni

Subjects
Neuroscience, Neurology, Physiology, Medical imaging, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Objective: The impact of visuospatial attention on perception with supraliminal stimuli and stimuli at the threshold of conscious perception has been previously investigated. In this study, we assess the cross-modal effects of visuospatial attention on conscious perception for near-threshold somatosensory stimuli applied to the face. Methods: Fifteen healthy participants completed two sessions of a near-threshold cross-modality cue-target discrimination/conscious detection paradigm. Each trial began with an endogenous visuospatial cue that predicted the location of a weak near-threshold electrical pulse delivered to the right or left cheek with high probability (∼75%). Participants then completed two tasks: first, a forced-choice somatosensory discrimination task (felt once or twice?) and then, a somatosensory conscious detection task (did you feel the stimulus and, if yes, where (left/right)?). Somatosensory discrimination was evaluated with the response reaction times of correctly detected targets, whereas the somatosensory conscious detection was quantified using perceptual sensitivity (d′) and response bias (beta). A 2 × 2 repeated measures ANOVA was used for statistical analysis. Results: In the somatosensory discrimination task (1st task), participants were significantly faster in responding to correctly detected targets (p < 0.001). In the somatosensory conscious detection task (2nd task), a significant effect of visuospatial attention on response bias (p = 0.008) was observed, suggesting that participants had a less strict criterion for stimuli preceded by spatially valid than invalid visuospatial cues. Conclusions: We showed that spatial attention has the potential to modulate the discrimination and the conscious detection of near-threshold somatosensory stimuli as measured, respectively, by a reduction of reaction times and a shift in response bias toward less conservative responses when the cue predicted stimulus location. A shift in response bias indicates possible effects of spatial attention on internal decision processes. The lack of significant results in perceptual sensitivity (d′) could be due to weaker effects of endogenous attention on perception.

Published
2018
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44. Assessment of sugarcane cultivars with stable reaction to Xanthomonas albilineans under mechanical inoculation conditions

Author

Yaquelin Puchades Izaguirre, Atilio Pedro Castagnaro, Gabriela Michavila, Joaquín Montalván Delgado, José María Mesa López, María Francisca Perera, Mario Casas González, Andrea Peña Malavera, Juana Pérez, Yosel Pérez Pérez, María de la Luz La O Hechavarría, and Omelio Carvajal Jaime

Subjects
Horticulture, Breeding program, biology, Bacterial isolate, Disease severity, Inoculation, Xanthomonas albilineans, Ammi, Cultivar, Cane, biology.organism_classification
Abstract

Leaf scald caused by Xanthomonas albilineans in sugarcane is one of the most important diseases around the world since it causes severe losses in both agricultural and industrial yields. In Cuba, resistance to this disease is considered a major selection criterion within the breeding program. The aim of this work was to detect sugarcane cultivars with stable reaction to X. albilineans by using both additive main effects and multiplicative interaction (AMMI) and linear general models. For this, 16 cultivars planted simultaneously in 2015, 2016, and 2017 in two locations: Jovellanos (Matanzas) and Florida (Camaguey) in Cuba were mechanically inoculated with a bacterial isolate previously characterized by sequencing its DNA fragment. Disease severity was recorded in plant cane and first ratoon, and results were consistent in both analyses and revealed that L55-5 and C323-68 were the most susceptible cultivars and C1051-73 was the most resistant; however, C1051-73, C275-80, C86-12, C88-382, C89-147, My5514, and Ty86-28 were the most stable across the years and localities evaluated. Results will allow adapting the methodology for the evaluation of the reaction to leaf scald of new sugarcane cultivars.

Published
2021

45. Twelve-Month Outcomes of the AFFINITY Trial of Fluoxetine for Functional Recovery After Acute Stroke: AFFINITY Trial Steering Committee on Behalf of the AFFINITY Trial Collaboration

Author

Graeme J. Hankey, Maree L. Hackett, Osvaldo P. Almeida, Leon Flicker, Gillian E. Mead, Martin S. Dennis, Christopher Etherton-Beer, Andrew H. Ford, Laurent Billot, Stephen Jan, Thomas Lung, Erik Lundström, Katharina S. Sunnerhagen, Craig S. Anderson, Huy Thang-Nguyen, John Gommans, Qilong Yi, Veronica Murray, Robert Herbert, Gregory Carter, Geoffrey A. Donnan, Huy-Thang Nguyen, Qiang Li, Severine Bompoint, Sarah Barrett, Anne Claxton, Julia O’Dea, Michelle Tang, Clare Williams, Shenae Peterson, Christie Drummond, Uyen-Ha Hong, Linh-Thi My Le, Tram-Thi Bich Ngo, Yen-Bao Mai, Huyen-Thanh Han, Nhu-Quynh Truong, Huong-Thi Nguyen, Hai-Thanh Ngo, Thi Binh Nguyen, Oanh-Thi Kieu Ha, Trang-Le Huyen Nguyen, Richard I. Lindley, Peter New, Andrew Lee, Thanh-Trung Tran, Loan-Tran Truc Mai Le, Thuy-Le Vu Kieu, Sang-Van Nguyen, Thuy-Anh Diem Nguyen, Tam-Nhat Dang, Hanh-Thi Truc Phan, Loan-Thi Ngoc Vo, Mai-Hue Nguyen, Hanh-Cao Dang, Hong-Thi Tran, Linh-Thi Cam Dam, Trinh-Thi Kim Ngo, Thai-Nguyen Thanh Pham, Binh-Nguyen Pham, Nha-Thi Thanh Dao, Huong-Thi Bich Nguyen, Linh-Thi Cam Le, Chi-Minh Do, Huy-Quoc Huynh, Giau-Thi Kim Tran, Oanh-Thi Le, Ly-Thi Khanh Tran, Chinh-Dinh Duong, Duong-Van Kieu, Na Le, Hoa-Ngoc Nguyen, Binh-Van Le, Long-Thanh Nguyen, Long-Van Nguyen, Tuan-Quoc Dinh, Tan-Van Vo, Tram-Ngoc Bui, Uyen-Thi To Hoang, Hien-Thi Bich Nguyen, Ha-Thi Thu Nguyen, Nga-Thuy Lam, Khanh-Kim Le, Phuong-Thanh Trinh, Hop-Quang Huynh, Thao-Thi Thu Nguyen, Huyen-Ngoc Lu, Tham-Hong Pham, Sam-Hoanh Nguyen, Ninh-Hong Le, Giang-Truong Nguyen, Bich-Thi Doan, Sung-Phuoc Pham, Duong-Huu Luong, Ha-Van Mai, Thuc-Van Tran, Phuong-Thi Do, Hoai-Thi Le, Chi-Van Nguyen, Phuong-Doan Nguyen, Ton-Duy Mai, Phuong-Viet Dao, Dung-Tien Nguyen, Dai-Quoc Khuong, Trung-Xuan Vuong, Lan-Tuong Vu, Ngoc-Duc Ngo, Hanh-Hong Dang, Phuong-Thai Truong, Ngan-Thi Le, Hoa-Van Hoang, Chung-Quang Do, Minh-Thao Nguyen, Anh-Hai Dam, Quynh-Nhu Le, Ngoc-Hoang Nguyen, Tuyen-Van Nguyen, Toan-Dinh Le, Ha-Thi Hai Dinh, Cuong–Van Pham, Khanh-Thi Ngoc Thach, Linh-Hai Nguyen, Loan-Thi Nguyen, Vien-Chi Le, Phuong-Hong Tran, Tai-Anh Nguyen, Tuan-Van Le, Luyen-Van Truong, Tue-Chau Bui, Ngoc-Xuan Huynh, Lap-Van Dinh, An-Gia Pham, Trang-Thi Huyen Le, Vy-Tuong Nguyen, Yen-Hai Nguyen, Thang-Ba Nguyen, Huy Thai, Quyen-Thi Ngoc Pham, Khoa-Duy Dao, Quoc-Nguyen Bao Pham, Thuong-Thi Huyen Dang, Huong-Huynh To Dinh, Trang-Mai Tong, Thuy-Thi Vu, Si-Tri Le, Tai-Ngoc Tran, Phuong-Hoai Tran, Ngoc-Thuy Nhu Dinh, Binh-Thanh Nguyen, Vinh-Phuong Do, Anh-Ngoc Nguyen, Binh-Thi Thanh Nguyen, David Blacker, Lindsey Bunce, Ai Ling Tan, Darshan Ghia, Gillian Edmonds, Nicole O’Loughlin, Megan Ewing, Kerri-Ann Whittaker, Lorralee Deane, Yash Gawarikar, Brett Jones, Maria Lopez, Koushik Nagesh, Emma Siracusa, Stephen Davis, Amy McDonald, Jess Tsoleridis, Rachael McCoy, David Jackson, Gab Silver, Timothy R. Bates, Amanda Boudville, Lynda Southwell, Dennis Cordato, Alan J. McDougall, Cecilia Cappelen-Smith, Zeljka Calic, Shabeel Askar, Qi Cheng, Raymond Kumar, Richard Geraghty, Maree Duroux, Megan Ratcliffe, Samantha Shone, Cassandra McLennan, Ramesh Sahathevan, Casey Hair, Stanley Levy, Beverley Macdonald, Benjamin Nham, Louise Rigney, Dev Nathani, Sumana Gopinath, Vishal Patel, Abul Mamun, Benjamin Trewin, Chun Phua, Ho Choong, Lauren Tarrant, Kerry Boyle, Luisa Hewitt, Monique Hourn, Amanda Masterson, Kim Oakley, Karen Ruddell, Colette Sanctuary, Kimberley Veitch, Camelia Burdusel, Lina Lee, Gary Cheuk, Jeremy Christley, Tabitha Hartwell, Craig Davenport, Kate Hickey, Rosanna Robertson, Michelle Carr, Sam Akbari, Hannah Coyle, Megan O’Neill, Cameron Redpath, Caroline Roberts, Marjan Tabesh, Toni Withiel, Kapila Abeysuriya, Andrew Granger, Angela Abraham, Chermaine Chua, Dung Do Nguyen, Vathani Surendran, Melissa Daines, David Shivlal, Mudassar Latif, Noreen Mughal, Patricia Morgan, Martin Krause, Miriam Priglinger, Ehsan E. Shandiz, Susan Day, Lay Kho, Michael Pollack, Judith Dunne, Helen Baines, Merridie Rees, Jenni White, Aicuratiya Withanage, Candice Delcourt, Cheryl Carcel, Alejandra Malavera, Amy Kunchok, Elizabeth Ray, Elizabeth Pepper, Emily Duckett, Sally Ormond, Andrew Moey, Timothy Kleinig, Vanessa Maxwell, Chantal Baldwin, Wilson Vallat, Deborah Field, Romesh Markus, Kirsty Page, Danielle Wheelwright, Sam Bolitho, Steven Faux, Fix Sangvatanakul, Alexis Brown, Susan Walker, Jennifer Massey, Hillary Hayes, Pesi Katrak, Annie Winker, Alessandro Zagami, Alanah Bailey, Sarah Mccormack, Andrew Murray, Mark Rollason, Christopher Taylor, Fintan O’Rourke, Ye Min Kuang, Heike Burnet, Yvonne Liu, Aileen Wu, Diana Ramirez, Tissa Wijeratne, Sherisse Celestino, Essie Low, Cynthia Chen, Jennifer Bergqvist, Andrew Evans, Queenie Leung, Martin Jude, Rachael McQueen, Katherine Mohr, Latitia Kernaghan, Paul Stockle, Boon L. Tan, Sara Laubscher, Diana Schmid, Melissa Spooner, Bhavesh Lallu, Bronwen Pepperell, John Chalissery, Karim Mahawish, Susan DeCaigney, Paula Broughton, Karen Knight, Veronica Duque, Harry McNaughton, Jeremy Lanford, Vivian Fu, and Lai-Kin Wong

Subjects
Male, medicine.medical_specialty, Steering committee, medicine.medical_treatment, Placebo, B700, Fractures, Bone, Cognition, Double-Blind Method, Recurrence, Seizures, Fluoxetine, Internal medicine, Humans, Medicine, Stroke, Fatigue, Aged, Ischemic Stroke, Acute stroke, Advanced and Specialized Nursing, business.industry, Recovery of Function, Middle Aged, Functional recovery, medicine.disease, Clinical trial, Affect, Hemorrhagic Stroke, Quality of Life, Accidental Falls, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Stroke recovery, Selective Serotonin Reuptake Inhibitors, medicine.drug
Abstract

Background and Purpose: The AFFINITY trial (Assessment of Fluoxetine in Stroke Recovery) reported that oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and seizures. After trial medication was ceased at 6 months, survivors were followed to 12 months post-randomization. This preplanned secondary analysis aimed to determine any sustained or delayed effects of fluoxetine at 12 months post-randomization. Methods: AFFINITY was a randomized, parallel-group, double-blind, placebo-controlled trial in adults (n=1280) with a clinical diagnosis of stroke in the previous 2 to 15 days and persisting neurological deficit who were recruited at 43 hospital stroke units in Australia (n=29), New Zealand (4), and Vietnam (10) between 2013 and 2019. Participants were randomized to oral fluoxetine 20 mg once daily (n=642) or matching placebo (n=638) for 6 months and followed until 12 months after randomization. The primary outcome was function, measured by the modified Rankin Scale, at 6 months. Secondary outcomes for these analyses included measures of the modified Rankin Scale, mood, cognition, overall health status, fatigue, health-related quality of life, and safety at 12 months. Results: Adherence to trial medication was for a mean 167 (SD 48) days and similar between randomized groups. At 12 months, the distribution of modified Rankin Scale categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio, 0.93 [95% CI, 0.76–1.14]; P =0.46). Compared with placebo, patients allocated fluoxetine had fewer recurrent ischemic strokes (14 [2.18%] versus 29 [4.55%]; P =0.02), and no longer had significantly more falls (27 [4.21%] versus 15 [2.35%]; P =0.08), bone fractures (23 [3.58%] versus 11 [1.72%]; P =0.05), or seizures (11 [1.71%] versus 8 [1.25%]; P =0.64) at 12 months. Conclusions: Fluoxetine 20 mg daily for 6 months after acute stroke had no delayed or sustained effect on functional outcome, falls, bone fractures, or seizures at 12 months poststroke. The lower rate of recurrent ischemic stroke in the fluoxetine group is most likely a chance finding. Registration: URL: http://www.anzctr.org.au/ ; Unique identifier: ACTRN12611000774921.

Published
2021

46. Process evaluation of complex interventions in non-communicable and neglected tropical diseases in low- and middle-income countries: a scoping review

Author

Lazo-Porras, Maria, Liu, Hueiming, Ouyang, Menglu, Yin, Xuejun, Malavera, Alejandra, Bressan, Tiana, Guzman-Vilca, Wilmer Cristobal, Pacheco, Niels, Benito, Melissa, Miranda, J Jaime, Moore, Graham, Chappuis, François, Perel, Pablo, and Beran, David

Abstract

Objectives The aim of this review is to map out the use of process evaluation (PE) in complex interventions that address non-communicable diseases (NCDs) and neglected tropical diseases (NTDs) to identify gaps in the design and conduct, as well as strengths, limitations and implications, of this type of research in low- and middle-income countries (LMICs).\ud\udDesign Scoping review of PE studies of complex interventions implemented in LMICs. Six databases were searched focused on studies published since 2008.\ud\udData sources Embase, PubMed, EbscoHost, Web of Science (WOS), Virtual Health Library (VHL) Regional Portal and Global Index Medicus: Regional Indexes AIM (AFRO), LILACS (AMRO/PAHO), IMEMR (EMRO), IMSEAR (SEARO), WPRIM (WPRO) Global Index Regional Indexes, MEDLINE, SciELO.\ud\udEligibility criteria Studies conducted in LMICs on PEs of randomised controlled trials (RCTs) and non-RCTs published between January 2008 and January 2020. Other criteria were studies of interventions for people at risk or having physical and mental NCDs, and/or NTDs, and/or their healthcare providers and/or others related to achieve better health for these two disease groups. Studies were excluded if they were not reported in English or Spanish or Portuguese or French, not peer-reviewed articles, not empirical research and not human research.\ud\udData extraction and synthesis Data extracted to be evaluated were: available evidence in the utilisation of PE in the areas of NCDs and NTDs, including frameworks and theories used; methods applied to conduct PEs; and in a subsample, the barriers and facilitators to implement complex interventions identified through the PE. Variables were extracted and categorised. The information was synthesised through quantitative analysis by reporting frequencies and percentages. Qualitative analysis was also performed to understand facilitators and barriers presented in these studies. The implications for PEs, and how the information from the PE was used by researchers or other stakeholders were also assessed in this approach.\ud\udResults 303 studies were identified, 79% were for NCDs, 12% used the label ‘PE’, 27% described a theory or framework for the PE, and 42% used mixed methods to analyse their findings. Acceptability, barriers and facilitators to implement the interventions, experiences and perceptions, and feasibility were the outcomes most frequently evaluated as part of the PEs. Barriers and facilitators themes identified were contextual factors, health system factors, human resources, attitudes and policy factors.\ud\udConclusions PEs in NCDs and NTDs are used in LMICs with a wide variety of methods. This review identified many PEs that were not labelled by the authors as such, as well as a limited application of PE-related theories and frameworks, and heterogeneous reporting of this type of study.

Published
2022

47. Novel alleles linked to brown rust resistance in sugarcane

Author

Chaves, Solana, primary, Ostengo, Santiago, additional, Bertani, Romina Priscila, additional, Peña Malavera, Andrea Natalia, additional, Cuenya, María Inés, additional, Filippone, María Paula, additional, Castagnaro, Atilio Pedro, additional, Balzarini, Mónica Graciela, additional, and Racedo, Josefina, additional

Published
2022
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49. TACTICS-Trial of Advanced CT Imaging and Combined Education Support for Drip and Ship: evaluating the effectiveness of an 'implementation intervention' in providing better patient access to reperfusion therapies: protocol for a non-randomised controlled stepped wedge cluster trial in acute stroke

Author

Ryan, A, Paul, CL, Cox, M, Whalen, O, Bivard, A, Attia, J, Bladin, C, Davis, SM, Campbell, BC, Parsons, M, Grimley, RS, Anderson, C, Donnan, GA, Oldmeadow, C, Kuhle, S, Walker, FR, Hood, RJ, Maltby, S, Keynes, A, Delcourt, C, Hatchwell, L, Malavera, A, Yang, Q, Wong, A, Muller, C, Sabet, A, Garcia-Esperon, C, Brown, H, Spratt, N, Kleinig, T, Butcher, K, Levi, CR, Ryan, A, Paul, CL, Cox, M, Whalen, O, Bivard, A, Attia, J, Bladin, C, Davis, SM, Campbell, BC, Parsons, M, Grimley, RS, Anderson, C, Donnan, GA, Oldmeadow, C, Kuhle, S, Walker, FR, Hood, RJ, Maltby, S, Keynes, A, Delcourt, C, Hatchwell, L, Malavera, A, Yang, Q, Wong, A, Muller, C, Sabet, A, Garcia-Esperon, C, Brown, H, Spratt, N, Kleinig, T, Butcher, K, and Levi, CR

Abstract

INTRODUCTION: Stroke reperfusion therapies, comprising intravenous thrombolysis (IVT) and/or endovascular thrombectomy (EVT), are best practice treatments for eligible acute ischemic stroke patients. In Australia, EVT is provided at few, mainly metropolitan, comprehensive stroke centres (CSC). There are significant challenges for Australia's rural and remote populations in accessing EVT, but improved access can be facilitated by a 'drip and ship' approach. TACTICS (Trial of Advanced CT Imaging and Combined Education Support for Drip and Ship) aims to test whether a multicomponent, multidisciplinary implementation intervention can increase the proportion of stroke patients receiving EVT. METHODS AND ANALYSIS: This is a non-randomised controlled, stepped wedge trial involving six clusters across three Australian states. Each cluster comprises one CSC hub and a minimum of three primary stroke centre (PSC) spokes. Hospitals will work in a hub and spoke model of care with access to a multislice CT scanner and CT perfusion image processing software (MIStar, Apollo Medical Imaging). The intervention, underpinned by behavioural theory and technical assistance, will be allocated sequentially, and clusters will move from the preintervention (control) period to the postintervention period. PRIMARY OUTCOME: Proportion of all stroke patients receiving EVT, accounting for clustering. SECONDARY OUTCOMES: Proportion of patients receiving IVT at PSCs, proportion of treated patients (IVT and/or EVT) with good (modified Rankin Scale (mRS) score 0-2) or poor (mRS score 5-6) functional outcomes and European Quality of Life Scale scores 3 months postintervention, proportion of EVT-treated patients with symptomatic haemorrhage, and proportion of reperfusion therapy-treated patients with good versus poor outcome who presented with large vessel occlusion at spokes. ETHICS AND DISSEMINATION: Ethical approval has been obtained from the Hunter New England Human Research Ethics Committee (18/09

Published
2022

50. Process Evaluation of an Implementation Trial: Design, Rationale, and Early Lessons Learnt From an International Cluster Clinical Trial in Intracerebral Hemorrhage

Author

Ouyang, Menglu, primary, Anderson, Craig S., additional, Song, Lili, additional, Malavera, Alejandra, additional, Jan, Stephen, additional, Cheng, Guojuan, additional, Chu, Honglin, additional, Hu, Xin, additional, Ma, Lu, additional, Chen, Xiaoying, additional, You, Chao, additional, and Liu, Hueiming, additional

Published
2022
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