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3. 18F-FDG PET can effectively rule out conversion to dementia and the presence of CSF biomarker of neurodegeneration: a real-world data analysis.

Author

Heyer, Sébastien, Simon, Maïa, Doyen, Matthieu, Mortada, Ali, Roch, Véronique, Jeanbert, Elodie, Thilly, Nathalie, Malaplate, Catherine, Kearney-Schwartz, Anna, Jonveaux, Thérèse, Bannay, Aurélie, and Verger, Antoine

Subjects
ALZHEIMER'S disease, POSITRON emission tomography, DISEASE risk factors, PROGNOSIS, DIAGNOSIS, MILD cognitive impairment
Abstract

Background: Precisely defining the delay in onset of dementia is a particular challenge for early diagnosis. Brain [18F] fluoro-2-deoxy-2-D-glucose (18F-FDG) Positron Emission Tomography (PET) is a particularly interesting tool for the early diagnosis of neurodegenerative diseases, through the measurement of the cerebral glucose metabolic rate. There is currently a lack of longitudinal studies under real-life conditions, with sufficient patients, to accurately evaluate the predictive values of brain 18F-FDG PET scans. Here, we aimed to estimate the value of brain 18F-FDG PET for predicting the risk of dementia conversion and the risk of occurrence of a neurodegenerative pathology. Methods: Longitudinal data for a cohort of patients with no diagnosis of dementia at the time of recruitment referred by a tertiary memory clinic for brain 18F-FDG PET were matched with (Prince M, Wimo A, Guerchet Maëlenn, Ali G-C, Wu Y-T et al. World Alzheimer Report 2015. The Global Impact of Dementia: An analysis of prevalence, incidence, cost and trends. [Research Report] Alzheimer's Disease International. 2015. 2015.) data from the French National Health Data System (NHDS), (Jack CR, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al. NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease. Alzheimers Dement. 2018;14(4):535–62.) data from the National Alzheimer Bank (NAB), and (Davis M, O'Connell T, Johnson S, Cline S, Merikle E, Martenyi F, et al. Estimating Alzheimer's Disease Progression Rates from Normal Cognition Through Mild Cognitive Impairment and Stages of Dementia. CAR. 2018;15(8):777–88.) lumbar puncture (LP) biomarker data. The criteria for dementia conversion were the designation, within the three years after the brain 18F-FDG PET scan, of a long-term condition for dementia in the NHDS and a dementia stage of cognitive impairment in the NAB. The criterion for the identification of a neurodegenerative disease in the medical records was the determination of LP biomarker levels. Results: Among the 403 patients (69.9 ± 11.4 years old, 177 women) from the initial cohort with data matched with the NHDS data, 137 were matched with the NAB data, and 61 were matched with LP biomarker data. Within three years of the scan, a 18F-FDG PET had negative predictive values of 85% for dementia conversion (according to the NHDS and NAB datasets) and 95% for the presence of LP neurodegeneration biomarkers. Conclusion: A normal brain 18F-FDG PET scan can help rule out the risk of dementia conversion and the presence of cerebrospinal fluid (CSF) biomarker of neurodegeneration early with high certainty, allowing modifications to patient management regimens in the short term. Trial registration: Clinical Trials database (NCT04804722). March 18, 2021. Retrospectively registered. [ABSTRACT FROM AUTHOR]

Published
2024
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5. The spectrum of biochemical alterations associated with organ dysfunction and inflammatory status and their association with disease outcomes in severe COVID-19: A longitudinal cohort and time-series design study

Author

Oussalah, Abderrahim, Gleye, Stanislas, Urmes, Isabelle Clerc, Laugel, Elodie, Barbé, Françoise, Orlowski, Sophie, Malaplate, Catherine, Aimone-Gastin, Isabelle, Caillierez, Beatrice Maatem, Merten, Marc, Jeannesson, Elise, Kormann, Raphaël, Olivier, Jean-Luc, Rodriguez-Guéant, Rosa-Maria, Namour, Farès, Bevilacqua, Sybille, Thilly, Nathalie, Losser, Marie-Reine, Kimmoun, Antoine, Frimat, Luc, Levy, Bruno, Gibot, Sébastien, Schvoerer, Evelyne, and Guéant, Jean-Louis

Published
2020
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7. Neuroprotective Effect of Curcumin-Loaded RGD Peptide-PEGylated Nanoliposomes

Author

Ben Mihoub, Amina, primary, Elkhoury, Kamil, additional, Nel, Janske, additional, Acherar, Samir, additional, Velot, Emilie, additional, Malaplate, Catherine, additional, Linder, Michel, additional, Latifi, Shahrzad, additional, Kahn, Cyril, additional, Huguet, Marion, additional, Yen, Frances T., additional, and Arab-Tehrany, Elmira, additional

Published
2023
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14. Targeted Suppression of Lipoprotein Receptor LSR in Astrocytes Leads to Olfactory and Memory Deficits in Mice

Author

El Hajj, Aseel, primary, Herzine, Ameziane, additional, Calcagno, Gaetano, additional, Désor, Frédéric, additional, Djelti, Fathia, additional, Bombail, Vincent, additional, Denis, Isabelle, additional, Oster, Thierry, additional, Malaplate, Catherine, additional, Vigier, Maxime, additional, Kaminski, Sandra, additional, Pauron, Lynn, additional, Corbier, Catherine, additional, Yen, Frances T., additional, Lanhers, Marie-Claire, additional, and Claudepierre, Thomas, additional

Published
2022
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15. Molecular Insights for Alzheimer’s Disease: An Unexplored Storyline on the Nanoscale Impact of Nascent Aβ1–42toward the Lipid Membrane

Author

Siniscalco, David, Francius, Grégory, Tarek, Mounir, Bali, Semiha Kevser, Laprévote, Olivier, Malaplate, Catherine, Oster, Thierry, Pauron, Lynn, and Quilès, Fabienne

Abstract

Deciphering the mechanism of Alzheimer’s disease is a key element for designing an efficient therapeutic strategy. Molecular dynamics (MD) calculations, atomic force microscopy, and infrared spectroscopy were combined to investigate β-amyloid (Aβ1–42) peptide interactions with supported lipid bilayers (SLBs). The MD simulations showed that nascent Aβ1–42monomers remain anchored within a model phospholipid bilayer’s hydrophobic core, which suggests their stability in their native environment. We tested this prediction experimentally by studying the behavior of Aβ1–42monomers and oligomers when interacting with SLBs. When Aβ1–42monomers and oligomers were self-assembled with a lipid bilayer and deposited as an SLB, they remain within the bilayers. Their presence in the bilayers induces destabilization of the model membranes. No specific interactions between Aβ1–42and the SLBs were detected when SLBs free of Aβ1–42were exposed to Aβ1–42. This study suggests that Aβ can remain in the membrane after cleavage by γ-secretase and cause severe damage to the membrane.

Published
2023
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16. Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

Author

Delaby, Constance, primary, Teunissen, Charlotte E., additional, Blennow, Kaj, additional, Alcolea, Daniel, additional, Arisi, Ivan, additional, Amar, Elodie Bouaziz, additional, Beaume, Anne, additional, Bedel, Aurélie, additional, Bellomo, Giovanni, additional, Bigot‐Corbel, Edith, additional, Bjerke, Maria, additional, Blanc‐Quintin, Marie‐Céline, additional, Boada, Mercè, additional, Bousiges, Olivier, additional, Chapman, Miles D, additional, DeMarco, Mari L., additional, D'Onofrio, Mara, additional, Dumurgier, Julien, additional, Dufour‐Rainfray, Diane, additional, Engelborghs, Sebastiaan, additional, Esselmann, Hermann, additional, Fogli, Anne, additional, Gabelle, Audrey, additional, Galloni, Elisabetta, additional, Gondolf, Clémentine, additional, Grandhomme, Frédérique, additional, Grau‐Rivera, Oriol, additional, Hart, Melanie, additional, Ikeuchi, Takeshi, additional, Jeromin, Andreas, additional, Kasuga, Kensaku, additional, Keshavan, Ashvini, additional, Khalil, Michael, additional, Körtvelyessy, Peter, additional, Kulczynska‐Przybik, Agnieszka, additional, Laplanche, Jean‐Louis, additional, Lewczuk, Piotr, additional, Li, Qiao‐Xin, additional, Lleó, Alberto, additional, Malaplate, Catherine, additional, Marquié, Marta, additional, Masters, Colin L., additional, Mroczko, Barbara, additional, Nogueira, Léonor, additional, Orellana, Adelina, additional, Otto, Markus, additional, Oudart, Jean‐Baptiste, additional, Paquet, Claire, additional, Paoletti, Federico Paolini, additional, Parnetti, Lucilla, additional, Perret‐Liaudet, Armand, additional, Peoc'h, Katell, additional, Poesen, Koen, additional, Puig‐Pijoan, Albert, additional, Quadrio, Isabelle, additional, Quillard‐Muraine, Muriel, additional, Rucheton, Benoit, additional, Schraen, Susanna, additional, Schott, Jonathan M., additional, Shaw, Leslie M., additional, Suárez‐Calvet, Marc, additional, Tsolaki, Magda, additional, Tumani, Hayrettin, additional, Udeh‐Momoh, Chinedu T, additional, Vaudran, Lucie, additional, Verbeek, Marcel M, additional, Verde, Federico, additional, Vermunt, Lisa, additional, Vogelgsang, Jonathan, additional, Wiltfang, Jens, additional, Zetterberg, Henrik, additional, and Lehmann, Sylvain, additional

Published
2021
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17. Use of Active Salmon-Lecithin Nanoliposomes to Increase Polyunsaturated Fatty Acid Bioavailability in Cortical Neurons and Mice

Author

Passeri, Elodie, primary, Elkhoury, Kamil, additional, Jiménez Garavito, Maria Camila, additional, Desor, Frédéric, additional, Huguet, Marion, additional, Soligot-Hognon, Claire, additional, Linder, Michel, additional, Malaplate, Catherine, additional, Yen, Frances T., additional, and Arab-Tehrany, Elmira, additional

Published
2021
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18. Influenza vaccination and prognosis of COVID ‐19 in hospitalized patients with diabetes: Results from the CORONADO study

Author

Diallo, A, Pichelin, Matthieu, Wargny, Matthieu, Gourdy, Pierre, Bonnet, JB, Hadjadj, Samy, Cariou, Bertrand, Sultan, Ariane, Galtier, Florence, Mahot, Pascale, Fournier‐Guilloux, Anne‐Laure, Mauduit, Nicolas, Bigot‐corbel, Edith, Boureau, Anne‐Sophie, Dekcer, Laure, Ernould, Audrey, Primot, Claire, Seguin, Anne, Joliveau, Marielle, Pouvreau, Sonia, FOURNIER, Chloé, Thureau, Jeremy, Fonteneau, Edith, Hublain, Pamela, Nantes, Chu, Agasse, Carole, Kergaradec, Mathilde DE, Minville, Vincent, Vardon‐Bounes, Fanny, Martin‐Blondel, Guillaume, Tramunt, Blandine, Turnin, Marie‐Christine, Hanaire, Hélène, Mansuy, Jean‐Michel, Fabre, Didier, Arhainx, Marie‐Blanche, Cazals, Laurent, Combes, Laure, Lami, Emmanuelle, Cianferani, Mallory, Megarbane, Bruno, Leroy, Pierre, Gautier, Jean‐François, Vidal‐Trecan, Tiphaine, Riveline, Jean‐Pierre, Laplanche, Jean‐Louis, Mouly, Stéphane, Potier, Louis, Roussel, Ronan, Taher, Malak, Abouleka, Yawa, Yaker, Fetta, Carlier, Aurelie, Boutten, Anne, Hallot‐Feron, Marilyne, Mourah, Fadila, Thivolet, Charles, Blond, Emilie, Rolland, Muriel, Mendez, Josep Verdecho, Alexandre, Marine, Pottecher, Julien, Richer, Emilie, Meyer, Laurent, Luca, Florina, Lessinger, Jean‐Marc, Bahougne, Thibault, Guerci, Bruno, Ludwig, Lisa, Benzirar, Siham, Malaplate, Catherine, Matton, Thierry, Poissy, Julien, Faure, Karine, Fontaine, Pierre, Baudoux, Florence, Vambergue, Anne, Pekar, Jean David, Lambert, Marc, Yelnik, Cécile, Bruandet, Amélie, Petit, Laurent, Neau, Didier, Rigalleau, Vincent, Berard, Annie, Galioot, Amandine, Coudroy, Remy, Thille, Arnaud, Robert, René, Roblot‐Cazenave, France, Rammaert, Blandine, Saulnier, Pierre Jean, Piguel, Xavier, Benhenda, Nesrine, Husson, Camille, Olivier, Celine, Torremocha, Florence, Fraty, Mathilde, d'assigny, Marie Flamen, Miot, Aurelie, Bossard, Valentin, Klouche, Kada, Makinson, Alain, Bonnet, Jean‐Baptiste, Foulongne, Vincent, Aubron, Cécile, Ansart, Séverine, Kerlan, Véronique, Quiniou, Pascale, Carre, Jean‐Luc, Quesnot, Stéphane, Laviolle, Bruno, Schwebel, Carole, Epaulard, Olivier, Benhamou, Pierre‐Yves, Betry, Cécile, Borel, Anne‐Laure, Lablanche, Sandrine, Guergour, Dorra, Duclos, Catherine, Cosson, Emmanuel, Guyot, Erwan, Deniau, Aurore, Nguyen, Phucthutrang, Reznik, Yves, Joubert, Michael, Allouche, Stéphane, Guittet, Lydia, Grange, Steven, Etienne, Manuel, Prévost, Gaëtan, Brunel, Valéry, Lagier, Jean‐Christophe, Raoult, Didier, Dutour, Anne, Gaborit, Bénédicte, Boulllu, Sandrine, Darmon, Patrice, Lasbleiz, Adèle, Cerino, Mathieu, Romain, Fanny, Houssays, Marie, Quenot, Jean Pierre, Piroth, Lionel, Vergès, Bruno, Duvillard, Laurence, Bonnotte, Bernard, Mercat, Alain, Dubee, Vincent, Allix, Ingrid, Rodien, Patrice, Dhersin, Robin, Lebeault, Maylis, Trzepizur, Wojciech, Loison, Jocelyne, Brangier, Antoine, Asfar, Pierre, Reynier, Pascal, Larcher, Françoise, Joubaud, Françoise, Andreu, Marie‐Rita, Urbanski, Geoffrey, Hubert, Laurent, Annweiler, Cedric, Dellamonica, Jean, Courjon, Johan, Chevalier, Nicolas, Chinetti, Giulia, Chafai, Magda, Mourvillier, Bruno, Bani‐Sadr, Firouze, Barraud, Sarra, Delemer, Brigitte, Gillery, Philippe, Labedade, Pascale, Chabrol, Amélie, Penfornis, Alfred, Petit, Catherine, Amadou, Coralie, Adler, Maxime, Dubost, Clément, Conan, Pierre‐Louis, Bordier, Lyse, Ceppa, Franck, Garcia, Cyril, Sollier, Mathilde, Dupuy, Olivier, Laplance, Sophie, Billuart, Olivier, Aroulanda, Marie Joseph, Olivier, Frédérique, Ayon, Florence, Wilhelm, Nathalie, Epelboin, Loic, Sabbah, Nadia, Charpin, Aurelie, Squara, Pierre, Belliard, Olivier, Dubois, Claude, Marre, Michel, Auchabie, Johann, Courtois, Roxane, Duriez, Thierry, Mergey, Tiphaine, Vallee, Laura, Seguin, Laetitia, Al‐Salameh, Abdallah, Lanoix, Jean‐Philippe, Soriot‐Thomas, Sandrine, Bourgeois‐Descouls, Anne‐Marie, Desailloud, Rachel, Germain, Natacha, Galusca, Bogdan, Belleton, Gwenaelle, Marouani, Nesrine, Palaghiu, Delia, Hammour, Amira, Berdaguer, Fernando, Klopfenstein, Thimothée, Zayet, Hajer, Winiszewski, Patrice, Zanusso, Marie, Garnier, Pauline, Julier, Ingrid, Hamzaoui, Karim, Marty‐Gres, Sophie, Sadki, Tarik, Cadot, Lucile, Dubost, Jean‐Louis, Gonfroy, Céline, Campinos, Catherine, Martres, Pascale, Coulhon, Marie Pierre, Allou, Nicolas, Bachir, Marwa, Hoang, Stella, Kembellec, Candice, Suply, Olivia, Kharcha, Fatima, Devouge, Anne‐Claire, Flaus‐Furmanuk, Anna, Madeline, Isabelle, Ehinger, Vincent, Bastard, Sophie, Raffray, Loic, Renou, Frederic, Bojarski, Aude, Paul, Caroline, Borsu, Karine, Gorlin, Angelique, Bernardo, Servane, Ut, Carole Truong, Renaud, Stephane, Vignoles, Antoine, Foch, Emilie, Masse, Laurie, Grand, Hubert, Ferrand, Helene, Raffaitin‐Cardin, Christelle, Zellagui, Hadjer, Castang‐Brachet, Celine, Boury, Frederique, Tena, Ana Alvarez, Moura, Isabelle, Kalfon, Pierre, Darasteanu, Juliana, Monier, Arnaud, Foucault, Pascal, Depuille, Alexandra, Laugier‐Robiolle, Stéphanie, Caneiro, Patrick, Basso, Maud, Larger, Etienne, Bouam, Samir, Benzenati, Wahiba, Bachir, Leila Ait, Pillegand, Camille Cussac, Vasse, Marc, Michard, Christophe, Montanier, Nathanaëlle, Millot, Luc, Crepet, Françoise, Ratsimba, Danielle, Bouiller, Kevin, Borot, Sophie, Bruckert, Isabelle, Clergeot, Annie, Schillo, Franck, Vignes, Dorothée, Bourgeon‐Ghittori, Muriel, Lachgar, Hamoud, Cursay, Claire Lambert DE, Levante, Stéphane, Auregan, Jean Charles, Merlet, Antoine, Zaragoza, Cécile, Arnault, Gwénaëlle, Loupp, Anne‐Gaëlle, Lesieur, Olivier, Roncato‐Saberan, Mariam, Gouet, Didier, Lemarie, Romain, Allano, Hong_an, Vivier, Emmanuel, Pariset, Caroline, Luyton, Cédric, Marchand, Lucien, Doroszewski, Fanny, Pecquet, Matthieu, Perard, Laurent, Vuillermoz‐Blas, Sylvie, Kacki, Nicolas, Charrier, Patricia, Ducet‐Boiffard, Amélie, Roure, Françoise Desroys, Bourron, Olivier, Bonnefont‐Rousselot, Dominique, Laroche, Suzanne, Phan, Franck, Hartemann, Agnès, CAUSSY, Cyrielle, Disse, Emmanuel, Guerin, Claude, Perpoint, Thomas, Moulin, Philippe, CARTIER, RÉGINE, Hariri, Geoffroy, Chopin, Dorothée, Vatier, Camille, Bourcigaux, Nathalie, Chaigneau, Emmanuelle, Christin‐Maitre, Sophie, Donadille, Bruno, Feve, Bruno, Lamothe, Sophie, Sarfati, Julie, Pernet, Pascal, Chambon, Anne, Demarsy, Delphine, Campagne, Hugo, Latil‐Plat, Françoise, Berne, Monica, Grinand, Marilyne, Touzet, Marion, Zabulon, Aydrey, Craspag, Jocelyne, Ledoux, Catherine, Contaret, Cedric, Janand‐Delenne, Blandine, Giraud, Anaïs, Lacrimini, Marie Lou, Arrivie, Joëlle, Ancelle, Deborah, Guillois, Carine, Fremy, Bénédicte, Chaalal, Amina, Barrande, Gaëlle, Dorange, Anne, Rouanet, Eglantine, Seret‐Begue, Dominique, Saoud, Audrey, Guedj, Anne‐Marie, Bedos, Nathalie, Velayoudom, Fritz‐Line, Dumas, Marie, Gonda, Benoite, Coffin, Christine, Gibiat, Stéphanie, Lungo, Myriam, Bully, Chantal, Serusclat, Pierre, Bully, Stella, Carre, Patricia, Leberre, Jean‐Philippe, Elkhoury, Carlos, THIEUX, Marine, Paradisi‐Prieur, Laetitia, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

Subjects
2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Hospitalized patients, Influenza vaccine, Endocrinology, Diabetes and Metabolism, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), [SDV]Life Sciences [q-bio], 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Diabetes mellitus, Influenza, Human, Internal Medicine, Diabetes Mellitus, Research Letter, Medicine, Humans, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, business.industry, SARS-CoV-2, Vaccination, COVID-19, medicine.disease, Prognosis, Research Letters, 3. Good health, Hospitalization, Propensity score matching, business
Abstract

International audience

Published
2021

21. International initiative for harmonization of cerebrospinal fluid diagnostic comments in Alzheimer's disease

Author

Delaby, Constance, Teunissen, Charlotte E, Alcolea, Daniel, Bouaziz-Amar, Elodie, Beaume, Anne, Bedel, Aurélie, Bigot-Corbel, Edith, Bjerke, Maria, Blanc, Marie-Céline, Bousiges, Olivier, Chapman, Miles D, DeMarco, Mari L, D'Onofrio, Mara, Dufour-Rainfray, Diane, Engelborghs, Sebastiaan, Esselmann, Hermann, Fogli, Anne, Galloni, Elisabetta, Gondolf, Clementine, Grandhomme, Frédérique, Grau-Rivera, Oriol, Hart, Melanie, Jeromin, Andreas, Keshavan, Ashvini, Khalil, Michael, Koertvelyessy, Peter, Kulczynska‐Przybik, Agnieska, Laplanche, Jean-Louis, Lleó, Alberto, Malaplate, Catherine, Mroszko, Barbara, Nogueira, Léonor, Orellana, Adelina, Otto, Markus, Oudart, Jean-Baptiste, Paquet, Claire, Parnetti, Lucilla, Perret-Liaudet, Armand, Poec, Katell, Poesen, Koen, Puig‐Pijoan, Albert, Quadrio, Isabelle, Quillard‐Muraine, Muriel, Rucheton, Benoit, Schraen, Susanna, Suárez‐Calvet, Marc, Tsolaki, Magda, Tumani, Hayrettin, Udeh‐Momoh, Chinedu T, Vaudran, Lucie, Verbeek, Marcel, Verde, Federico, Vermunt, Lisa, Vogelgsang, Jonathan, Wiltfang, Jens, Zetterberg, Henrik, Lehmann, Sylvain, Clinical Biology, Clinical sciences, Neurology, and Neuroprotection & Neuromodulation

Published
2020

22. International initiative for harmonization of cerebrospinal fluid diagnostic comments in Alzheimer's disease

Author

Delaby, Constance, primary, Teunissen, Charlotte E, additional, Alcolea, Daniel, additional, Amar, Elodie Bouaziz, additional, Beaume, Anne, additional, Bedel, Aurélie, additional, Bigot‐Corbel, Edith, additional, Bjerke, Maria, additional, Blanc, Marie‐Céline, additional, Bousiges, Olivier, additional, Chapman, Miles D, additional, DeMarco, Mari L, additional, D'Onofrio, Mara, additional, Dufour‐Rainfray, Diane, additional, Engelborghs, Sebastiaan, additional, Esselmann, Hermann, additional, Fogli, Anne, additional, Galloni, Elisabetta, additional, Gondolf, Clémentine, additional, Grandhomme, Frédérique, additional, Grau‐Rivera, Oriol, additional, Hart, Melanie, additional, Jeromin, Andreas, additional, Keshavan, Ashvini, additional, Khalil, Michael, additional, Koertvelyessy, Peter, additional, Kulczynska‐Przybik, Agnieszka, additional, Laplanche, Jean‐Louis, additional, Lleó, Alberto, additional, Malaplate, Catherine, additional, Mroszko, Barbara, additional, Nogueira, Léonor, additional, Orellana, Adelina, additional, Otto, Markus, additional, Oudart, Jean‐Baptiste, additional, Paquet, Claire, additional, Parnetti, Lucilla, additional, Perret‐Liaudet, Armand, additional, Poec, Katell, additional, Poesen, Koen, additional, Puig‐Pijoan, Albert, additional, Quadrio, Isabelle, additional, Quillard‐Muraine, Muriel, additional, Rucheton, Benoit, additional, Schraen, Susanna, additional, Suárez‐Calvet, Marc, additional, Tsolaki, Magda, additional, Tumani, Hayrettin, additional, Udeh‐Momoh, Chinedu T, additional, Vaudran, Lucie, additional, Verbeek, Marcel M, additional, Verde, Federico, additional, Vermunt, Lisa, additional, Vogelgsang, Jonathan, additional, Wiltfang, Jens, additional, Zetterberg, Henrik, additional, and Lehmann, Sylvain, additional

Published
2020
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24. Long-term ACE Inhibitor/ARB Use Is Associated With Severe Renal Dysfunction and Acute Kidney Injury in Patients With Severe COVID-19: Results From a Referral Center Cohort in the Northeast of France

Author

Oussalah, Abderrahim, primary, Gleye, Stanislas, primary, Clerc Urmes, Isabelle, primary, Laugel, Elodie, primary, Callet, Jonas, primary, Barbé, Françoise, primary, Orlowski, Sophie, primary, Malaplate, Catherine, primary, Aimone-Gastin, Isabelle, primary, Caillierez, Beatrice Maatem, primary, Merten, Marc, primary, Jeannesson, Elise, primary, Kormann, Raphaël, primary, Olivier, Jean-Luc, primary, Rodriguez-Guéant, Rosa-Maria, primary, Namour, Farès, primary, Bevilacqua, Sybille, primary, Losser, Marie-Reine, primary, Levy, Bruno, primary, Kimmoun, Antoine, primary, Gibot, Sébastien, primary, Thilly, Nathalie, primary, Frimat, Luc, primary, Schvoerer, Evelyne, primary, and Guéant, Jean-Louis, primary

Published
2020
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25. Follow-Up of Multi-Organ Dysfunction and Inflammation Using Biomarker Kinetics in Patients with Severe COVID-19 Disease and Association with Disease Outcomes: Results from a Referral Center Cohort in the North East of France

Author

Oussalah, Abderrahim, primary, Gleye, Stanislas, additional, Urmes, Isabelle Clerc, additional, Laugel, Elodie, additional, Barbé, Françoise, additional, Orlowski, Sophie, additional, Malaplate, Catherine, additional, Aimone-Gastin, Isabelle, additional, Caillierez, Beatrice Maatem, additional, Merten, Marc, additional, Jeannesson, Elise, additional, Kormann, Raphaël, additional, Olivier, Jean-Luc, additional, Rodriguez-Guéan, Rosa-Maria, additional, Namour, Farès, additional, Bevilacqua, Sybille, additional, Thilly, Nathalie, additional, Losser, Marie-Reine, additional, Kimmoun, Antoine, additional, Frimat, Luc, additional, Levy, Bruno, additional, Gibot, Sébastien, additional, Schvoerer, Evelyne, additional, and Gueant, Jean-Louis, additional

Published
2020
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26. Kinetics of Biomarkers Associated with Organ Dysfunction and Inflammatory Status and Their Association with Disease Outcomes in Severe COVID-19: A Longitudinal Cohort Study

Author

Oussalah, Abderrahim, primary, Gleye, Stanislas, additional, Urmes, Isabelle Clerc, additional, Laugel, Elodie, additional, Barbé, Françoise, additional, Orlowski, Sophie, additional, Malaplate, Catherine, additional, Aimone-Gastin, Isabelle, additional, Caillierez, Beatrice Maatem, additional, Merten, Marc, additional, Jeannesson, Elise, additional, Kormann, Raphaël, additional, Olivier, Jean-Luc, additional, Rodriguez-Guéant, Rosa-Maria, additional, Namour, Farès, additional, Bevilacqua, Sybille, additional, Thilly, Nathalie, additional, Losser, Marie-Reine, additional, Kimmoun, Antoine, additional, Frimat, Luc, additional, Levy, Bruno, additional, Gibot, Sébastien, additional, Schvoerer, Evelyne, additional, and Gueant, Jean-Louis, additional

Published
2020
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27. Neurotrophic Effect of Fish-Lecithin Based Nanoliposomes on Cortical Neurons

Author

Malaplate, Catherine, Poerio, Aurelia, Huguet, Marion, Soligot, Claire, Passeri, Elodie, Kahn, Cyril J. F., Linder, Michel, Arab-Tehrany, Elmira, Yen, Frances T., Yen, Frances T, ISITE - Isite LUE - - LUE2015 - ANR-15-IDEX-0004 - IDEX - VALID, Unité de Recherches Animal et Fonctionnalités des Produits Animaux (URAFPA), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Laboratoire d'Ingénierie des Biomolécules (LIBio), Université de Lorraine (UL), Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Santé et de la Recherche Médicale (INSERM), IMPACT Biomolécules, ANR-15-IDEX-0004,LUE,Isite LUE(2015), Université de Lorraine (UL)-Institut National de la Recherche Agronomique (INRA), and Hôpital de Brabois, CHU de Nancy, Vandoeuvre-lès-Nancy

Subjects
Drug Compounding, brain, Primary Cell Culture, Drug Evaluation, Preclinical, Article, Salmon, Fatty Acids, Omega-3, Lecithins, Animals, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], lcsh:QH301-705.5, Cells, Cultured, Cerebral Cortex, Neurons, Neuronal Plasticity, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, Green Chemistry Technology, Embryo, Mammalian, n-3 fatty acids, Rats, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, lcsh:Biology (General), Liposomes, Synapses, lipids (amino acids, peptides, and proteins), nanoparticles, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

Lipids play multiple roles in preserving neuronal function and synaptic plasticity, and polyunsaturated fatty acids (PUFAs) have been of particular interest in optimizing synaptic membrane organization and function. We developed a green-based methodology to prepare nanoliposomes (NL) from lecithin that was extracted from fish head by-products. These NL range between 100&ndash, 120 nm in diameter, with an n-3/n-6 fatty acid ratio of 8.88. The high content of n-3 PUFA (46.3% of total fatty acid content) and docosahexanoic acid (26%) in these NL represented a means for enrichment of neuronal membranes that are potentially beneficial for neuronal growth and synaptogenesis. To test this, the primary cultures of rat embryo cortical neurons were incubated with NL on day 3 post-culture for 24 h, followed by immunoblots or immunofluorescence to evaluate the NL effects on synaptogenesis, axonal growth, and dendrite formation. The results revealed that NL-treated cells displayed a level of neurite outgrowth and arborization on day 4 that was similar to those of untreated cells on day 5 and 6, suggesting accelerated synapse formation and neuronal development in the presence of NL. We propose that fish-derived NL, by virtue of their n-3 PUFA profile and neurotrophic effects, represent a new innovative bioactive vector for developing preventive or curative treatments for neurodegenerative diseases.

Published
2019

28. Age-related changes in regiospecific expression of Lipolysis Stimulated Receptor (LSR) in mice brain

Author

El Hajj, Aseel, Yen, Frances T., Oster, Thierry, Malaplate, Catherine, Pauron, Lynn, Corbier, Catherine, Lanhers, Marie-Claire, Claudepierre, Thomas, Unité de Recherches Animal et Fonctionnalités des Produits Animaux (URAFPA), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), Service de Biochimie et Biologie Moléculaire, Nutrition et Métabolisme [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), IMPACT Biomolécules, ANR-15-IDEX-04-LUE,LUE,Lorraine Université d'Excellence(2016), Université de Lorraine (UL)-Institut National de la Recherche Agronomique (INRA), and ANR-15-IDEX-0004,LUE (ISITE),Lorraine Université d'Excellence(2016)

Subjects
Central Nervous System, Male, Aging, Lipoproteins, Lipolysis, Science, Hypothalamus, Biochemistry, Nervous System, Hippocampus, Mice, Animal Cells, Cerebellum, Medicine and Health Sciences, Animals, Homeostasis, Humans, Tissue Distribution, RNA, Messenger, Lipoprotein Receptors, Receptors, Lipoprotein, Neurons, Cerebral Cortex, [SCCO.NEUR]Cognitive science/Neuroscience, Biology and Life Sciences, Proteins, Brain, Cell Biology, Lipids, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], Mice, Inbred C57BL, Cholesterol, nervous system, Cellular Neuroscience, Medicine, lipids (amino acids, peptides, and proteins), Anatomy, Cellular Types, Transcriptome, Neuroglia, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Research Article, Neuroscience, Signal Transduction
Abstract

International audience; The regulation of cholesterol, an essential brain lipid, ensures proper neuronal development and function, as demonstrated by links between perturbations of cholesterol metabolism and neurodegenerative diseases, including Alzheimer's disease. The central nervous system (CNS) acquires cholesterol via de novo synthesis, where glial cells provide cholesterol to neurons. Both lipoproteins and lipoprotein receptors are key elements in this intercellular transport, where the latter recognize, bind and endocytose cholesterol containing glia-produced lipoproteins. CNS lipoprotein receptors are like those in the periphery, among which include the ApoB, E binding lipolysis stimulated lipoprotein receptor (LSR). LSR is a multi-meric protein complex that has multiple isoforms including α and α', which are seen as a dou-blet at 68 kDa, and β at 56 kDa. While complete inactivation of murine lsr gene is embryonic lethal, studies on lsr +/-mice revealed altered brain cholesterol distribution and cognitive functions. In the present study, LSR profiling in different CNS regions revealed regiospecific expression of LSR at both RNA and protein levels. At the RNA level, the hippocampus, hypo-thalamus, cerebellum, and olfactory bulb, all showed high levels of total lsr compared to whole brain tissues, whereas at the protein level, only the hypothalamus, olfactory bulb, and retina showed the highest levels of total LSR. Interestingly, major regional changes in LSR expression were observed in aged mice which suggests changes in cholesterol homeostasis in specific structures in the aging brain. Immunocytostaining of primary cultures of mature murine neurons and glial cells isolated from different CNS regions showed that LSR is expressed in both neurons and glial cells. However, lsr RNA expression in the cerebellum was predominantly higher in glial cells, which was confirmed by the immunocytostaining profile of cerebellar neurons and glia. Based on this observation, we would propose that LSR in glial cells may play a key role in glia-neuron cross talk, particularly in the feedback control of cholesterol synthesis to avoid cholesterol overload in neurons and to maintain proper functioning of the brain throughout life.

Published
2019

30. Clinical impact of digital and conventional PET control databases for semi-quantitative analysis of brain 18F-FDG digital PET scans.

Author

Mairal, Elise, Doyen, Matthieu, Rivasseau-Jonveaux, Thérèse, Malaplate, Catherine, Guedj, Eric, and Verger, Antoine

Subjects
DIGITAL cameras, IMAGE databases, ALZHEIMER'S disease
Abstract

Purpose: Digital PET cameras markedly improve sensitivity and spatial resolution of brain 18F-FDG PET images compared to conventional cameras. Our study aimed to assess whether specific control databases are required to improve the diagnostic performance of these recent advances. Methods: We retrospectively selected two groups of subjects, twenty-seven Alzheimer's Disease (AD) patients and twenty-two healthy control (HC) subjects. All subjects underwent a brain 18F-FDG PET on a digital camera (Vereos, Philips®). These two group (AD and HC) are compared, using a Semi-Quantitative Analysis (SQA), to two age and sex matched controls acquired with a digital PET/CT (Vereos, Philips®) or a conventional PET/CT (Biograph 6, Siemens®) camera, at group and individual levels. Moreover, individual visual interpretation of SPM T-maps was provided for the positive diagnosis of AD by 3 experienced raters. Results: At group level, SQA using digital controls detected more marked hypometabolic areas in AD (+ 116 cm3 at p < 0.001 uncorrected for the voxel, corrected for the cluster) than SQA using conventional controls. At the individual level, the accuracy of SQA for discriminating AD using digital controls was higher than SQA using conventional controls (86% vs. 80%, p < 0.01, at p < 0.005 uncorrected for the voxel, corrected for the cluster), with higher sensitivity (89% vs. 78%) and similar specificity (82% vs. 82%). These results were confirmed by visual analysis (accuracies of 84% and 82% for digital and conventional controls respectively, p = 0.01). Conclusion: There is an urgent need to establish specific digital PET control databases for SQA of brain 18F-FDG PET images as such databases improve the accuracy of AD diagnosis. [ABSTRACT FROM AUTHOR]

Published
2020
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31. Biologie et maladies neurodégénératives : la sclérose en plaques

Author

Malaplate-Armand, Catherine, Malaplate, Catherine, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Unité de Recherches Animal et Fonctionnalités des Produits Animaux (URAFPA), and Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

32. Les marqueurs du LSC avec profil discordant et imagerie PET amyloïde

Author

Malaplate-Armand, Catherine, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), and Malaplate, Catherine

Subjects
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

33. Increasing the Survival of a Neuronal Model of Alzheimer's Disease Using Docosahexaenoic Acid, Restoring Endolysosomal Functioning by Modifying the Interactions between the Membrane Proteins C99 and Rab5.

Author

Vigier M, Uriot M, Djelti-Delbarba F, Claudepierre T, El Hajj A, Yen FT, Oster T, and Malaplate C

Subjects
Humans, Cell Line, Tumor, Amyloid beta-Protein Precursor metabolism, Apoptosis, Neuroprotective Agents pharmacology, Cell Survival drug effects, Docosahexaenoic Acids pharmacology, Docosahexaenoic Acids metabolism, Alzheimer Disease metabolism, Alzheimer Disease pathology, rab5 GTP-Binding Proteins metabolism, Endosomes metabolism, Neurons metabolism, Neurons pathology, Neurons drug effects, Lysosomes metabolism
Abstract

Docosahexaenoic acid (DHA, C22:6 ω3) may be involved in various neuroprotective mechanisms that could prevent Alzheimer's disease (AD). Its influence has still been little explored regarding the dysfunction of the endolysosomal pathway, known as an early key event in the physiopathological continuum triggering AD. This dysfunction could result from the accumulation of degradation products of the precursor protein of AD, in particular the C99 fragment, capable of interacting with endosomal proteins and thus contributing to altering this pathway from the early stages of AD. This study aims to evaluate whether neuroprotection mediated by DHA can also preserve the endolysosomal function. AD-typical endolysosomal abnormalities were recorded in differentiated human SH-SY5Y neuroblastoma cells expressing the Swedish form of human amyloid precursor protein. This altered phenotype included endosome enlargement, the reduced secretion of exosomes, and a higher level of apoptosis, which confirmed the relevance of the cellular model chosen for studying the associated deleterious mechanisms. Second, neuroprotection mediated by DHA was associated with a reduced interaction of C99 with the Rab5 GTPase, lower endosome size, restored exosome production, and reduced neuronal apoptosis. Our data reveal that DHA may influence protein localization and interactions in the neuronal membrane environment, thereby correcting the dysfunction of endocytosis and vesicular trafficking associated with AD.

Published
2024
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34. Molecular Insights for Alzheimer's Disease: An Unexplored Storyline on the Nanoscale Impact of Nascent Aβ 1-42 toward the Lipid Membrane.

Author

Siniscalco D, Francius G, Tarek M, Bali SK, Laprévote O, Malaplate C, Oster T, Pauron L, and Quilès F

Subjects
Humans, Amyloid beta-Peptides chemistry, Peptide Fragments chemistry, Lipid Bilayers chemistry, Alzheimer Disease
Abstract

Deciphering the mechanism of Alzheimer's disease is a key element for designing an efficient therapeutic strategy. Molecular dynamics (MD) calculations, atomic force microscopy, and infrared spectroscopy were combined to investigate β-amyloid (Aβ 1-42 ) peptide interactions with supported lipid bilayers (SLBs). The MD simulations showed that nascent Aβ 1-42 monomers remain anchored within a model phospholipid bilayer's hydrophobic core, which suggests their stability in their native environment. We tested this prediction experimentally by studying the behavior of Aβ 1-42 monomers and oligomers when interacting with SLBs. When Aβ 1-42 monomers and oligomers were self-assembled with a lipid bilayer and deposited as an SLB, they remain within the bilayers. Their presence in the bilayers induces destabilization of the model membranes. No specific interactions between Aβ 1-42 and the SLBs were detected when SLBs free of Aβ 1-42 were exposed to Aβ 1-42 . This study suggests that Aβ can remain in the membrane after cleavage by γ-secretase and cause severe damage to the membrane.

Published
2023
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35. Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview.

Author

Delaby C, Teunissen CE, Blennow K, Alcolea D, Arisi I, Amar EB, Beaume A, Bedel A, Bellomo G, Bigot-Corbel E, Bjerke M, Blanc-Quintin MC, Boada M, Bousiges O, Chapman MD, DeMarco ML, D'Onofrio M, Dumurgier J, Dufour-Rainfray D, Engelborghs S, Esselmann H, Fogli A, Gabelle A, Galloni E, Gondolf C, Grandhomme F, Grau-Rivera O, Hart M, Ikeuchi T, Jeromin A, Kasuga K, Keshavan A, Khalil M, Körtvelyessy P, Kulczynska-Przybik A, Laplanche JL, Lewczuk P, Li QX, Lleó A, Malaplate C, Marquié M, Masters CL, Mroczko B, Nogueira L, Orellana A, Otto M, Oudart JB, Paquet C, Paoletti FP, Parnetti L, Perret-Liaudet A, Peoc'h K, Poesen K, Puig-Pijoan A, Quadrio I, Quillard-Muraine M, Rucheton B, Schraen S, Schott JM, Shaw LM, Suárez-Calvet M, Tsolaki M, Tumani H, Udeh-Momoh CT, Vaudran L, Verbeek MM, Verde F, Vermunt L, Vogelgsang J, Wiltfang J, Zetterberg H, and Lehmann S

Subjects
Humans, Biomarkers cerebrospinal fluid, Amyloid beta-Peptides cerebrospinal fluid, tau Proteins cerebrospinal fluid, Peptide Fragments cerebrospinal fluid, Alzheimer Disease diagnosis, Alzheimer Disease cerebrospinal fluid
Abstract

Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests., Methods: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients., Results: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis., Discussion: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD., (© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)

Published
2022
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36. Age-related changes in regiospecific expression of Lipolysis Stimulated Receptor (LSR) in mice brain.

Author

El Hajj A, Yen FT, Oster T, Malaplate C, Pauron L, Corbier C, Lanhers MC, and Claudepierre T

Subjects
Aging genetics, Animals, Brain anatomy & histology, Cholesterol metabolism, Homeostasis, Humans, Lipolysis, Male, Mice, Mice, Inbred C57BL, Neuroglia metabolism, Neurons metabolism, RNA, Messenger genetics, RNA, Messenger metabolism, Receptors, Lipoprotein deficiency, Receptors, Lipoprotein genetics, Tissue Distribution, Transcriptome, Aging metabolism, Brain metabolism, Receptors, Lipoprotein metabolism
Abstract

The regulation of cholesterol, an essential brain lipid, ensures proper neuronal development and function, as demonstrated by links between perturbations of cholesterol metabolism and neurodegenerative diseases, including Alzheimer's disease. The central nervous system (CNS) acquires cholesterol via de novo synthesis, where glial cells provide cholesterol to neurons. Both lipoproteins and lipoprotein receptors are key elements in this intercellular transport, where the latter recognize, bind and endocytose cholesterol containing glia-produced lipoproteins. CNS lipoprotein receptors are like those in the periphery, among which include the ApoB, E binding lipolysis stimulated lipoprotein receptor (LSR). LSR is a multimeric protein complex that has multiple isoforms including α and α', which are seen as a doublet at 68 kDa, and β at 56 kDa. While complete inactivation of murine lsr gene is embryonic lethal, studies on lsr +/- mice revealed altered brain cholesterol distribution and cognitive functions. In the present study, LSR profiling in different CNS regions revealed regiospecific expression of LSR at both RNA and protein levels. At the RNA level, the hippocampus, hypothalamus, cerebellum, and olfactory bulb, all showed high levels of total lsr compared to whole brain tissues, whereas at the protein level, only the hypothalamus, olfactory bulb, and retina showed the highest levels of total LSR. Interestingly, major regional changes in LSR expression were observed in aged mice which suggests changes in cholesterol homeostasis in specific structures in the aging brain. Immunocytostaining of primary cultures of mature murine neurons and glial cells isolated from different CNS regions showed that LSR is expressed in both neurons and glial cells. However, lsr RNA expression in the cerebellum was predominantly higher in glial cells, which was confirmed by the immunocytostaining profile of cerebellar neurons and glia. Based on this observation, we would propose that LSR in glial cells may play a key role in glia-neuron cross talk, particularly in the feedback control of cholesterol synthesis to avoid cholesterol overload in neurons and to maintain proper functioning of the brain throughout life., Competing Interests: The authors have declared that no competing interests exist.

Published
2019
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