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10. Oral-Based Techniques for the Diagnosis of Infectious Diseases

Author

Malamud, D., Abrams, W. R., Bau, H., Wang, J., Chen, Z., Paul Corstjens, and Niedbala, S.

Subjects
Diagnosis, Oral, Point-of-Care Systems, Humans, RNA, DNA, General Medicine, Saliva, Communicable Diseases, Diagnostic Techniques and Procedures
Abstract

Saliva and other types of oral samples can readily be used for noninvasive diagnosis of diseases of the oral cavity and systemic diseases. Following an introduction outlining the types of oral samples and the analytes that can be measured in these samples, a detailed description of a novel oral-based diagnostic system to detect multiple bacterial and/or viral pathogens is presented. A reasonably priced, portable, point-of-care diagnostic system should be available within five years.

Published
2006

11. The Effect of an Oral Care Intervention in Decreasing the Expression of Proinflammatory Cytokines in Patients Receiving Chemoradiation for Oral Cancer: A Randomized Clinical Trial

Author

Sanfilippo, N.J., primary, Vasconcelos, R., additional, Moya, J., additional, Malamud, D., additional, Barber, C., additional, Smith, B.E., additional, DeLacure, M., additional, Kerr, R., additional, Schmidt, B., additional, Myssiorek, D., additional, and Corby, P., additional

Published
2016
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24. Development of a Microfluidic Device for Detection of Pathogens in Oral Samples Using Upconverting Phosphor Technology (UPT)

Author

ABRAMS, W. R, primary, BARBER, C. A, additional, MCCANN, K., additional, TONG, G., additional, CHEN, Z., additional, MAUK, M. G, additional, WANG, J., additional, VOLKOV, A., additional, BOURDELLE, P., additional, CORSTJENS, P. L. A. M, additional, ZUIDERWIJK, M., additional, KARDOS, K., additional, LI, S., additional, TANKE, H. J, additional, SAM NIEDBALA, R, additional, MALAMUD, D., additional, and BAU, H., additional

Published
2007
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43. Patient and provider acceptance of oral HIV screening in a dental school setting.

Author

Nassry DD, Phelan JA, Ghookasian M, Barber CA, Norman RG, Lloyd MM, Schenkel A, Malamud D, Abrams WR, Nassry, David D, Phelan, Joan A, Ghookasian, Miganoush, Barber, Cheryl A, Norman, Robert G, Lloyd, Madeleine M, Schenkel, Andrew, Malamud, Daniel, and Abrams, William R

Abstract

In 2006, the Centers for Disease Control and Prevention (CDC) recommended routine HIV screening in health care settings regardless of the patient's level of risk. This pilot study was developed in response to the suggestion by some health care professionals that dental settings would be appropriate for expansion of HIV testing. This project consisted of two parts: oral fluid HIV testing of patients in the clinic of a dental school and a survey of the clinical dental faculty members' attitudes about acceptability of routine HIV testing in the dental clinic. When patients' agreement to participate in oral fluid HIV testing was examined, 8.2 percent of the patients contacted by the clinic administration staff completed testing. When approached by a faculty member or student during the dental visit admission and tested during the dental visit, however, 88.2 percent completed testing. Of the faculty members who took the survey, 27.4 percent were neutral, 26.4 percent were somewhat in agreement, and 32.1 percent were willing to incorporate HIV testing into routine dental care. In this pilot study, HIV testing of dental patients was most successful when a dental care provider approached patients about testing. If consent was given, the testing was performed during the visit. For the faculty members, the major barrier to testing was a lack of protocol familiarity. [ABSTRACT FROM AUTHOR]

Published
2012
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48. Distribution of a spermicide containing Nonoxynol-9 in the vaginal canal and the upper female reproductive tract.

Author

Barnhart, K.T., Stolpen, A., Pretorius, E.S., and Malamud, D.

Abstract

Topical, intravaginal microbicides and spermicides are greatly needed to prevent transmission of sexually transmitted diseases and/or unwanted pregnancies. The development of such compounds is a high research priority. The presumed method of action of existing, or novel, microbicides/spermicides is to provide a chemical barrier to the vaginal epithelium preventing exposure to micro-organisms. Other intravaginal products are used to treat vaginal bacteria of fungal infections. Little is known, however, about the actual or optimal initial distribution and subsequent spread of medications placed in the vagina. We describe a sensitive new technique to quantify the spread of a gel placed in the vagina using magnetic resonance imaging (MRI). Five millilitres of an over-the-counter spermicide containing Nonoxynol-9 was mixed with Gadolinium. MRI was used to quantify spread of the mixture 10 min after insertion with a standard applicator. We demonstrated contiguous spread of gel throughout the vagina. The coverage of material was thicker in the upper vagina than in the lower vagina. We also demonstrated, for the first time, that spermicidal compounds may migrate from the vaginal canal into the endocervix within 10 min of insertion. This finding suggests that topical microbicides/spermicides may act both in the vaginal canal and in the upper female genital tract. [ABSTRACT FROM AUTHOR]

Published
2001
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49. A Skeptical Biochemist

Author

Malamud, D.

Subjects
A Skeptical Biochemist (Book) -- Book reviews, Books -- Book reviews, Library and information science, Literature/writing
Published
1993

50. Oral diagnostic testing for detecting human immunodeficiency virus-1 antibodies: a technology whose time has come.

Author

Malamud, D

Subjects
*DIAGNOSIS of HIV infections, *IMMUNOGLOBULIN analysis, *COMPARATIVE studies, *HIV, *IMMUNOGLOBULINS, *RESEARCH methodology, *MEDICAL cooperation, *ORAL disease diagnosis, *RESEARCH, *SALIVA, *VIRAL antibodies, *EVALUATION research
Abstract

An oral fluid-based test for antibodies to human immunodeficiency virus (HIV), equivalent to serum in its accuracy but safer and easier to use, is now available in the United States. The development of the oral test involved overcoming technical obstacles to the use of oral fluid as a testing medium, including low immunoglobulin G (IgG) titers, suboptimal assay performance, protease degradation of IgG, high viscosity, and lack of a standardized method of specimen collection, all of which contribute to suboptimal assay performance. The currently available oral HIV test utilizes a collection device to isolate a mucosal transudate component of oral fluid rich in IgG. A vial containing a preservative solution facilitates the transport of stable, low-viscosity specimens to the laboratory for testing with an ELISA and confirmatory Western blot assay, specifically designed for use with oral fluid. Non-HIV medical conditions and oral pathologies do not appear to affect oral test results. Hopefully, the availability of a more patient-friendly, portable diagnostic test for antibodies to HIV will facilitate identification of greater numbers of infected individuals with the ultimate goals of early identification, early treatment, and prevention of disease transmission. [ABSTRACT FROM AUTHOR]

Published
1997
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