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1. Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study

Author

Andreou, A., Bartsch, F., Benzing, C., Buettner, S., Capobianco, I., Charco, R., de Reuver, P.R., de Savornin Lohman, E., Dejong, C.H.C., Efanov, M., Erdmann, J.I., Franken, L.C., Giglio, M.C., Gomez-Gavara, C., Hagendoorn, J., Heid, F., IJzermans, J.N.M., Kazemier, G., Maithel, S.K., Malago, M., Malik, H.Z., Molenaar, Q.I., Muiesan, P., Nooijen, L.E., Nota, C.L.M., Olde Damink, S.W.M., Pratschke, J., Quinn, L.M., Ratti, F., Ravaioli, M., Roberts, K.J., Rolinger, J., Ruzzenente, A., Schadde, E., Schmelzle, M., Serenari, M., Sultana, A., van Laarhoven, S., van Vugt, J.L.A., Zonderhuis, B.M., Jansson, Hannes, Olthof, Pim B., Bergquist, Annika, Ligthart, Marjolein A.P., Nadalin, Silvio, Troisi, Roberto I., Groot Koerkamp, Bas, Alikhanov, Ruslan, Lang, Hauke, Guglielmi, Alfredo, Cescon, Matteo, Jarnagin, William R., Aldrighetti, Luca, van Gulik, Thomas M., and Sparrelid, Ernesto

Published
2021
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5. Complications After Pediatric Liver Transplantation

Author

Oldhafer, K. J., Malagó, M., Dömland, M., Wallot, M., Vester, U., Broelsch, C. E., Baert, A. L., editor, Sartor, K., editor, Bücheler, E., editor, Nicolas, V., editor, Broelsch, C. E., editor, Rogiers, X., editor, and Krupski, G., editor

Published
2003
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6. Surgical Techniques in Adult Liver Transplantation

Author

Frühauf, N. R., Malagó, M., Kaiser, G. M., Lang, H., Paul, A., Clauer, U. A., Frilling, A., Broelsch, C. E., Baert, A. L., editor, Sartor, K., editor, Bücheler, E., editor, Nicolas, V., editor, Broelsch, C. E., editor, Rogiers, X., editor, and Krupski, G., editor

Published
2003
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9. Surgery for Bismuth-Corlette Type 4 Perihilar Cholangiocarcinoma: Results from a Western Multicenter Collaborative Group

Author

Ruzzenente, Andrea, Bagante, Fabio, Olthof, Pim B, Aldrighetti, Luca, Alikhanov, Ruslan, Cescon, Matteo, Koerkamp, Bas Groot, Jarnagin, William R, Nadalin, Silvio, Pratschke, Johann, Schmelzle, Moritz, Sparrelid, Ernesto, Lang, Hauke, Iacono, Calogero, van Gulik, Thomas M, Guglielmi, Alfredo, Andreou A, Bartsch F, Benzing C, Buettner S, Campagnaro T, Capobianco I, Charco R, de Reuver P, de Savornin, Lohman E, Nijmegen, Dejong CHC, Efanov M, Erdmann JI, Franken LC, Giovinazzo G, Giglio MC, Gomez-Gavara C, Heid F, IJzermans JNM, Isaac J, Jansson H, Ligthart MAP, Maithel SK, Malago` M. Malik HZ, Muiesan P, Olde Damink SWM, Quinn LM, Ratti F, Ravaioli M, Rolinger J, Schadde E, Serenari M, Troisi R, van Laarhoven S, van Vugt JLA, Faculteit Medische Wetenschappen/UMCG, Surgery, Ruzzenente, Andrea, Bagante, Fabio, Olthof, Pim B, Aldrighetti, Luca, Alikhanov, Ruslan, Cescon, Matteo, Koerkamp, Bas Groot, Jarnagin, William R, Nadalin, Silvio, Pratschke, Johann, Schmelzle, Moritz, Sparrelid, Ernesto, Lang, Hauke, Iacono, Calogero, van Gulik, Thomas M, Guglielmi, Alfredo, Andreou, A, Bartsch, F, Benzing, C, Buettner, S, Campagnaro, T, Capobianco, I, Charco, R, de Reuver, P, De, Savornin, Lohman, E, Nijmegen, Dejong, Chc, Efanov, M, Erdmann, Ji, Franken, Lc, Giovinazzo, G, Giglio, Mc, Gomez-Gavara, C, Heid, F, Ijzermans, Jnm, Isaac, J, Jansson, H, Ligthart, Map, Maithel, Sk, Malago` M., Malik HZ, Muiesan, P, Olde Damink, Swm, Quinn, Lm, Ratti, F, Ravaioli, M, Rolinger, J, Schadde, E, Serenari, M, Troisi, R, van Laarhoven, S, van Vugt, Jla, Ruzzenente, A., Bagante, F., Olthof, P. B., Aldrighetti, L., Alikhanov, R., Cescon, M., Koerkamp, B. G., Jarnagin, W. R., Nadalin, S., Pratschke, J., Schmelzle, M., Sparrelid, E., Lang, H., Iacono, C., van Gulik, T. M., Guglielmi, A., Andreou, A., Bartsch, F., Benzing, C., Buettner, S., Campagnaro, T., Capobianco, I., Charco, R., de Reuver, P., de Savornin Lohman, E., Dejong, C. H. C., Efanov, M., Erdmann, J. I., Franken, L. C., Giovinazzo, G., Giglio, M. C., Gomez-Gavara, C., Heid, F., Ijzermans, J. N. M., Isaac, J., Jansson, H., Ligthart, M. A. P., Maithel, S. K., Malago, M., Malik, H. Z., Muiesan, P., Damink, S. W. M. O., Quinn, L. M., Ratti, F., Ravaioli, M., Rolinger, J., Schadde, E., Serenari, M., Troisi, R., van Laarhoven, S., van Vugt, J. L. A., CCA - Cancer Treatment and Quality of Life, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
medicine.medical_specialty, medicine.medical_treatment, Perineural invasion, Metastasis, Cholangiocarcinoma, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Surgical oncology, Medicine, Hepatectomy, Humans, Perihilar Cholangiocarcinoma, Contraindication, Retrospective Studies, business.industry, Incidence (epidemiology), medicine.disease, Surgery, Oncology, Bile Duct Neoplasms, Cohort, business, Bismuth, Klatskin Tumor
Abstract

Background Although Bismuth-Corlette (BC) type 4 perihilar cholangiocarcinoma (pCCA) is no longer considered a contraindication for curative surgery, few data are available from Western series to indicate the outcomes for these patients. This study aimed to compare the short- and long-term outcomes for patients with BC type 4 versus BC types 2 and 3 pCCA undergoing surgical resection using a multi-institutional international database. Methods Uni- and multivariable analyses of patients undergoing surgery at 20 Western centers for BC types 2 and 3 pCCA and BC type 4 pCCA. Results Among 1138 pCCA patients included in the study, 826 (73%) had BC type 2 or 3 disease and 312 (27%) had type 4 disease. The two groups demonstrated significant differences in terms of clinicopathologic characteristics (i.e., portal vein embolization, extended hepatectomy, and positive margin). The incidence of severe complications was 46% for the BC types 2 and 3 patients and 51% for the BC type 4 patients (p = 0.1). Moreover, the 90-day mortality was 13% for the BC types 2 and 3 patients and 12% for the BC type 4 patients (p = 0.57). Lymph-node metastasis (N1; hazard-ratio [HR], 1.62), positive margins (R1; HR, 1.36), perineural invasion (HR, 1.53), and poor grade of differentiation (HR, 1.25) were predictors of survival (all p ≤0.004), but BC type was not associated with prognosis. Among the N0 and R0 patients, the 5-year overall survival was 43% for the patients with BC types 2 and 3 pCCA and 41% for those with BC type 4 pCCA (p = 0.60). Conclusions In this analysis of a large Western multi-institutional cohort, resection was shown to be an acceptable curative treatment option for selected patients with BC type 4 pCCA although a more technically challenging surgical approach was required.

Published
2020

10. HIV in der Transplantationsmedizin

Author

Frühauf, N. R., Frilling, A., Malago, M., Broelsch, C. E., Brockmeyer, Norbert H., editor, Hoffmann, Klaus, editor, Reimann, G., editor, Stücker, Markus, editor, Altmeyer, Peter, editor, and Brodt, R., editor

Published
2000
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16. Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study

Author

Jansson, Hannes, primary, Olthof, Pim B., additional, Bergquist, Annika, additional, Ligthart, Marjolein A.P., additional, Nadalin, Silvio, additional, Troisi, Roberto I., additional, Groot Koerkamp, Bas, additional, Alikhanov, Ruslan, additional, Lang, Hauke, additional, Guglielmi, Alfredo, additional, Cescon, Matteo, additional, Jarnagin, William R., additional, Aldrighetti, Luca, additional, van Gulik, Thomas M., additional, Sparrelid, Ernesto, additional, Andreou, A., additional, Bartsch, F., additional, Benzing, C., additional, Buettner, S., additional, Capobianco, I., additional, Charco, R., additional, de Reuver, P.R., additional, de Savornin Lohman, E., additional, Dejong, C.H.C., additional, Efanov, M., additional, Erdmann, J.I., additional, Franken, L.C., additional, Giglio, M.C., additional, Gomez-Gavara, C., additional, Hagendoorn, J., additional, Heid, F., additional, IJzermans, J.N.M., additional, Kazemier, G., additional, Maithel, S.K., additional, Malago, M., additional, Malik, H.Z., additional, Molenaar, Q.I., additional, Muiesan, P., additional, Nooijen, L.E., additional, Nota, C.L.M., additional, Olde Damink, S.W.M., additional, Pratschke, J., additional, Quinn, L.M., additional, Ratti, F., additional, Ravaioli, M., additional, Roberts, K.J., additional, Rolinger, J., additional, Ruzzenente, A., additional, Schadde, E., additional, Schmelzle, M., additional, Serenari, M., additional, Sultana, A., additional, van Laarhoven, S., additional, van Vugt, J.L.A., additional, and Zonderhuis, B.M., additional

Published
2021
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17. Correction to: Portal Vein Embolization is Associated with Reduced Liver Failure and Mortality in High-Risk Resections for Perihilar Cholangiocarcinoma (Annals of Surgical Oncology, (2020), 10.1245/s10434-020-08258-3)

Author

Olthof P. B., Aldrighetti L., Alikhanov R., Cescon M., Groot Koerkamp B., Jarnagin W. R., Nadalin S., Pratschke J., Schmelzle M., Sparrelid E., Lang H., Guglielmi A., van Gulik T. M., Andreou A., Bartsch F., Benzing C., Buettner S., Capobianco I., de Reuver P., de Savornin Lohman E., Dejong C. H. C., Efanov M., Erdmann J. I., Franken L. C., Frascaroli G., Giglio M. C., Gomez-Gavara C., Heid F., IJzermans J. N. M., Jansson H., Ligthart M. A. P., Maithel S. K., Malago M., Malik H. Z., Muiesan P., Olde Damink S. W. M., Pando E., Quinn L. M., Ratti F., Roberts K. J., Rolinger J., Ruzzenente A., Schadde E., Serenari M., Sultana A., Troisi R., van Laarhoven S., van Vugt J. L. A., Olthof, P. B., Aldrighetti, L., Alikhanov, R., Cescon, M., Groot Koerkamp, B., Jarnagin, W. R., Nadalin, S., Pratschke, J., Schmelzle, M., Sparrelid, E., Lang, H., Guglielmi, A., van Gulik, T. M., Andreou, A., Bartsch, F., Benzing, C., Buettner, S., Capobianco, I., de Reuver, P., de Savornin Lohman, E., Dejong, C. H. C., Efanov, M., Erdmann, J. I., Franken, L. C., Frascaroli, G., Giglio, M. C., Gomez-Gavara, C., Heid, F., Ijzermans, J. N. M., Jansson, H., Ligthart, M. A. P., Maithel, S. K., Malago, M., Malik, H. Z., Muiesan, P., Olde Damink, S. W. M., Pando, E., Quinn, L. M., Ratti, F., Roberts, K. J., Rolinger, J., Ruzzenente, A., Schadde, E., Serenari, M., Sultana, A., Troisi, R., van Laarhoven, S., and van Vugt, J. L. A.

Abstract

In the original article Moritz Schmelzle’s last name is spelled wrong. It is correct as reflected here.

Published
2020

18. Portal Vein Embolization is Associated with Reduced Liver Failure and Mortality in High-Risk Resections for Perihilar Cholangiocarcinoma

Author

Olthof, P. B., Aldrighetti, L., Alikhanov, R., Cescon, M., Groot Koerkamp, B., Jarnagin, W. R., Nadalin, S., Pratschke, J., Schmelze, M., Sparrelid, E., Lang, H., Guglielmi, A., van Gulik, T. M., Andreou, A., Bartsch, F., Benzing, C., Buettner, S., Capobianco, I., de Reuver, P., de Savornin Lohman, E., Dejong, C. H. C., Efanov, M., Erdmann, J. I., Franken, L. C., Frascaroli, G., Giglio, M. C., Gomez-Gavara, C., Heid, F., IJzermans, J. N. M., Jansson, H., Ligthart, M. A. P., Maithel, S. K., Malago, M., Malik, H. Z., Muiesan, P., Olde Damink, S. W. M., Pando, E., Quinn, L. M., Ratti, F., Roberts, K. J., Rolinger, J., Ruzzenente, A., Schadde, E., Serenari, M., Sultana, A., Troisi, R., van Laarhoven, S., van Vugt, J. L. A., Surgery, Academic Medical Center, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Olthof, P. B., Aldrighetti, L., Alikhanov, R., Cescon, M., Groot Koerkamp, B., Jarnagin, W. R., Nadalin, S., Pratschke, J., Schmelze, M., Sparrelid, E., Lang, H., Guglielmi, A., van Gulik, T. M., Andreou, A., Bartsch, F., Benzing, C., Buettner, S., Capobianco, I., de Reuver, P., de Savornin Lohman, E., Dejong, C. H. C., Efanov, M., Erdmann, J. I., Franken, L. C., Frascaroli, G., Giglio, M. C., Gomez-Gavara, C., Heid, F., Ijzermans, J. N. M., Jansson, H., Ligthart, M. A. P., Maithel, S. K., Malago, M., Malik, H. Z., Muiesan, P., Olde Damink, S. W. M., Pando, E., Quinn, L. M., Ratti, F., Roberts, K. J., Rolinger, J., Ruzzenente, A., Schadde, E., Serenari, M., Sultana, A., Troisi, R., van Laarhoven, S., and van Vugt, J. L. A.

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, education, 030230 surgery, Preoperative care, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 03 medical and health sciences, 0302 clinical medicine, Retrospective Studie, Preoperative Care, medicine, Hepatectomy, Humans, Embolization, Abscess, Bile Duct Neoplasm, Aged, Retrospective Studies, portal vein embolization, portal vein embolisation, Perihilar cholangiocarcinoma, Portal Vein, business.industry, Incidence (epidemiology), Liver Neoplasms, Correction, Retrospective cohort study, Middle Aged, Jaundice, medicine.disease, Embolization, Therapeutic, Surgery, Bile Duct Neoplasms, Oncology, Liver Neoplasm, Hepatobiliary Tumors, 030220 oncology & carcinogenesis, Propensity score matching, Cohort, medicine.symptom, business, Liver Failure, Human, Klatskin Tumor
Abstract

Background Preoperative portal vein embolization (PVE) is frequently used to improve future liver remnant volume (FLRV) and to reduce the risk of liver failure after major liver resection. Objective This paper aimed to assess postoperative outcomes after PVE and resection for suspected perihilar cholangiocarcinoma (PHC) in an international, multicentric cohort. Methods Patients undergoing resection for suspected PHC across 20 centers worldwide, from the year 2000, were included. Liver failure, biliary leakage, and hemorrhage were classified according to the respective International Study Group of Liver Surgery criteria. Using propensity scoring, two equal cohorts were generated using matching parameters, i.e. age, sex, American Society of Anesthesiologists classification, jaundice, type of biliary drainage, baseline FLRV, resection type, and portal vein resection. Results A total of 1667 patients were treated for suspected PHC during the study period. In 298 patients who underwent preoperative PVE, the overall incidence of liver failure and 90-day mortality was 27% and 18%, respectively, as opposed to 14% and 12%, respectively, in patients without PVE (p p = 0.005). After propensity score matching, 98 patients were enrolled in each cohort, resulting in similar baseline and operative characteristics. Liver failure was lower in the PVE group (8% vs. 36%, p p p = 0.01), and 90-day mortality (7% vs. 18%, p = 0.03). Conclusion PVE before major liver resection for PHC is associated with a lower incidence of liver failure, biliary leakage, abscess formation, and mortality. These results demonstrate the importance of PVE as an integral component in the surgical treatment of PHC.

Published
2020

19. ASO Visual Abstract

Author

Ruzzenente, A., Bagante, F., Olthof, P.B., Aldrighetti, L., Alikhanov, R., Cescon, M., Koerkamp, B.G., Jarnagin, W.R., Nadalin, S., Pratschke, J., Schmelzle, M., Sparrelid, E., Lang, H., Iacono, C., van Gulik, T.M., Guglielmi, A., Andreou, A., Bartsch, F., Benzing, C., Buettner, S., Campagnaro, T., Capobianco, I., Charco, R., de Reuver, P., de Savornin Lohman, E., Dejong, C.H.C., Efanov, M., Erdmann, J.I., Franken, L.C., Giovinazzo, G., Giglio, M.C., Gomez-Gavara, C., Heid, F., Ijzermans, J.N.M., Isaac, J., Jansson, H., Ligthart, M.A.P., Maithel, S.K., Malago, M., Malik, H.Z., Muiesan, P., Damink, S.W.M.O., Quinn, L.M., Ratti, F., Ravaioli, M., Rolinger, J., Schadde, E., Serenari, M., Troisi, R., van Laarhoven, S., van Vugt, J.L.A., Surgery, CCA - Cancer Treatment and Quality of Life, and Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Intrahepatic, medicine.medical_specialty, business.industry, General surgery, MEDLINE, Cholangiocarcinoma, Collaborative group, Settore MED/18 - Chirurgia Generale, Oncology, Bile Duct Neoplasms, Surgical oncology, medicine, Humans, Surgery, Bile Ducts, Perihilar Cholangiocarcinoma, business, Bismuth, Bile Ducts, Intrahepatic, Klatskin Tumor
Published
2021

29. Liver Transplantation for Hilar Cholangiocarcinoma: A German Survey

Author

Kaiser, G.M., Sotiropoulos, G.C., Jauch, K.W., Löhe, F., Hirner, A., Kalff, J.C., Königsrainer, A., Steurer, W., Senninger, N., Brockmann, J.G., Schlitt, H.J., Zülke, C., Büchler, M.W., Schemmer, P., Settmacher, U., Hauss, J., Lippert, H., Hopt, U.T., Otto, G., Heiss, M.M., Bechstein, W.O., Timm, S., Klar, E., Hölscher, A.H., Rogiers, X., Stangl, M., Hohenberger, W., Müller, V., Molmenti, E.P., Fouzas, I., Erhard, J., Malagó, M., Paul, A., Broelsch, C.E., and Lang, H.

Published
2008
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32. Leberlebendspende

Author

Broelsch, C.E., Malago, M., Frilling, A., Nadalin, S., Malamutmann, E., Klein, C., and Gerken, G.

Published
2008
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33. Correction to: Portal Vein Embolization is Associated with Reduced Liver Failure and Mortality in High-Risk Resections for Perihilar Cholangiocarcinoma (Annals of Surgical Oncology, (2020), 10.1245/s10434-020-08258-3)

Author

Olthof, P.B. (Pim B.), Aldrighetti, L.A. (L.), Alikhanov, R. (Ruslan), Cescon, M. (Matteo), Groot Koerkamp, B. (Bas), Jarnagin, W.R. (William R.), Nadalin, S. (S.), Pratschke, J. (Johann), Schmelzle, M. (Moritz), Sparrelid, E. (Ernesto), Lang, H. (Hauke), Guglielmi, A. (Alfredo), Gulik, T.M. (Thomas) van, Andreou, A. (A.), Bartsch, F. (F.), Benzing, C. (C.), Büttner, S. (Stefan), Capobianco, I. (I.), Reuver, P.R. (Philip) de, de Savornin Lohman, E. (E.), Dejong, C.H. (Cees), Efanov, M. (M.), Erdmann, J.I. (J. I.), Franken, L.C. (L. C.), Frascaroli, G. (G.), Giglio, M.C. (M. C.), Gomez-Gavara, C. (C.), Heid, F. (F.), IJzermans, J.N.M. (Jan), Jansson, H. (H.), Ligthart, M.A.P. (M. A.P.), Maithel, S.K. (Shishir K.), Malago, M. (M.), Malik, H.Z. (H. Z.), Muiesan, P. (Paolo), Olde Damink, S.W.M. (Steven), Pando, E. (E.), Quinn, L.M. (L. M.), Ratti, F. (F.), Roberts, K.J. (K. J.), Rolinger, J. (J.), Ruzzenente, A. (Andrea), Schadde, E. (E.), Serenari, M. (M.), Sultana, A. (A.), Troisi, R.I., van Laarhoven, S. (S.), Vugt, J.L.A. (Jeroen) van, Olthof, P.B. (Pim B.), Aldrighetti, L.A. (L.), Alikhanov, R. (Ruslan), Cescon, M. (Matteo), Groot Koerkamp, B. (Bas), Jarnagin, W.R. (William R.), Nadalin, S. (S.), Pratschke, J. (Johann), Schmelzle, M. (Moritz), Sparrelid, E. (Ernesto), Lang, H. (Hauke), Guglielmi, A. (Alfredo), Gulik, T.M. (Thomas) van, Andreou, A. (A.), Bartsch, F. (F.), Benzing, C. (C.), Büttner, S. (Stefan), Capobianco, I. (I.), Reuver, P.R. (Philip) de, de Savornin Lohman, E. (E.), Dejong, C.H. (Cees), Efanov, M. (M.), Erdmann, J.I. (J. I.), Franken, L.C. (L. C.), Frascaroli, G. (G.), Giglio, M.C. (M. C.), Gomez-Gavara, C. (C.), Heid, F. (F.), IJzermans, J.N.M. (Jan), Jansson, H. (H.), Ligthart, M.A.P. (M. A.P.), Maithel, S.K. (Shishir K.), Malago, M. (M.), Malik, H.Z. (H. Z.), Muiesan, P. (Paolo), Olde Damink, S.W.M. (Steven), Pando, E. (E.), Quinn, L.M. (L. M.), Ratti, F. (F.), Roberts, K.J. (K. J.), Rolinger, J. (J.), Ruzzenente, A. (Andrea), Schadde, E. (E.), Serenari, M. (M.), Sultana, A. (A.), Troisi, R.I., van Laarhoven, S. (S.), and Vugt, J.L.A. (Jeroen) van

Abstract

In the original article Moritz Schmelzle’s last name is spelled wrong. It is correct as reflected here.

Published
2020
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34. Portal Vein Embolization is Associated with Reduced Liver Failure and Mortality in High-Risk Resections for Perihilar Cholangiocarcinoma

Author

Olthof, P.B. (Pim B.), Aldrighetti, L.A. (L.), Alikhanov, R. (Ruslan), Cescon, M. (Matteo), Groot Koerkamp, B. (Bas), Jarnagin, W.R. (William R.), Nadalin, S. (S.), Pratschke, J. (Johann), Schmelze, M. (Moritz), Sparrelid, E. (Ernesto), Lang, H. (Hauke), Guglielmi, A. (Alfredo), Gulik, T.M. (Thomas) van, Andreou, A. (A.), Bartsch, F. (F.), Benzing, C. (C.), Büttner, S. (Stefan), Capobianco, I. (I.), Reuver, P.R. (Philip) de, de Savornin Lohman, E. (E.), Dejong, C.H.C. (C. H.C.), Efanov, M. (M.), Erdmann, J.I. (Joris), Franken, L.C. (L. C.), Frascaroli, G. (G.), Giglio, M.C. (M. C.), Gomez-Gavara, C. (C.), Heid, F. (F.), IJzermans, J.N.M. (Jan), Jansson, H. (H.), Ligthart, M.A.P. (M. A.P.), Maithel, S.K. (Shishir K.), Malago, M. (M.), Malik, H.Z. (H. Z.), Muiesan, P. (Paolo), Olde Damink, S.W.M. (Steven), Pando, E. (E.), Quinn, L.M. (L. M.), Ratti, F. (F.), Roberts, K.J. (K. J.), Rolinger, J. (J.), Ruzzenente, A. (Andrea), Schadde, E. (E.), Serenari, M. (M.), Sultana, A. (A.), Troisi, R.I., van Laarhoven, S. (S.), Vugt, J.L.A. (Jeroen) van, Olthof, P.B. (Pim B.), Aldrighetti, L.A. (L.), Alikhanov, R. (Ruslan), Cescon, M. (Matteo), Groot Koerkamp, B. (Bas), Jarnagin, W.R. (William R.), Nadalin, S. (S.), Pratschke, J. (Johann), Schmelze, M. (Moritz), Sparrelid, E. (Ernesto), Lang, H. (Hauke), Guglielmi, A. (Alfredo), Gulik, T.M. (Thomas) van, Andreou, A. (A.), Bartsch, F. (F.), Benzing, C. (C.), Büttner, S. (Stefan), Capobianco, I. (I.), Reuver, P.R. (Philip) de, de Savornin Lohman, E. (E.), Dejong, C.H.C. (C. H.C.), Efanov, M. (M.), Erdmann, J.I. (Joris), Franken, L.C. (L. C.), Frascaroli, G. (G.), Giglio, M.C. (M. C.), Gomez-Gavara, C. (C.), Heid, F. (F.), IJzermans, J.N.M. (Jan), Jansson, H. (H.), Ligthart, M.A.P. (M. A.P.), Maithel, S.K. (Shishir K.), Malago, M. (M.), Malik, H.Z. (H. Z.), Muiesan, P. (Paolo), Olde Damink, S.W.M. (Steven), Pando, E. (E.), Quinn, L.M. (L. M.), Ratti, F. (F.), Roberts, K.J. (K. J.), Rolinger, J. (J.), Ruzzenente, A. (Andrea), Schadde, E. (E.), Serenari, M. (M.), Sultana, A. (A.), Troisi, R.I., van Laarhoven, S. (S.), and Vugt, J.L.A. (Jeroen) van

Abstract

Background: Preoperative portal vein embolization (PVE) is frequently used to improve future liver remnant volume (FLRV) and to reduce the risk of liver failure after major liver resection. Objective: This paper aimed to assess postoperative outcomes after PVE and resection for suspected perihilar cholangiocarcinoma (PHC) in an international, multicentric cohort. Methods: Patients undergoing resection for suspected PHC across 20 centers worldwide, from the year 2000, were included. Liver failure, biliary leakage, and hemorrhage were classified according to the respective International Study Group of Liver Surgery criteria. Using propensity scoring, two equal cohorts were generated using matching parameters, i.e. age, sex, American Society of Anesthesiologists classification, jaundice, type of biliary drainage, baseline FLRV, resection type, and portal vein resection. Results: A total of 1667 patients were treated for suspected PHC during the study period. In 298 patients who underwent preoperative PVE, the overall incidence of liver failure and 90-day mortality was 27% and 18%, respectively, as opposed to 14% and 12%, respectively, in patients without PVE (p < 0.001 and p = 0.005). After propensity score matching, 98 patients were enrolled in each cohort, resulting in similar baseline and operative characteristics. Liver failure was lower in the PVE group (8% vs. 36%, p < 0.001), as was biliary leakage (10% vs. 35%, p < 0.01), intra-abdominal abscesses (19% vs. 34%, p = 0.01), and 90-day mortality (7% vs. 18%, p = 0.03). Conclusion: PVE before major liver resection for PHC is associated with a lower incidence of liver failure, biliary leakage, abscess formation, and mortality. These results demonstrate the importance of PVE as an integral component in the surgical treatment of PHC.

Published
2020
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36. Safety profile of concomitant use of caspofungin and cyclosporine or tacrolimus in liver transplant patients

Author

Saner, F., Gensicke, J., Rath, P., Fruhauf, N., Gu, Y., Paul, A., Radtke, A., Malago, M., and Broelsch, C.

Subjects
Caspofungin -- Dosage and administration, Caspofungin -- Research, Tacrolimus -- Dosage and administration, Tacrolimus -- Research, Cyclosporine -- Dosage and administration, Cyclosporine -- Research, Organ transplant recipients -- Drug therapy, Organ transplant recipients -- Research, Health
Abstract

Byline: F. Saner (1), J. Gensicke (1), P. Rath (2), N. Fruhauf (1), Y. Gu (1), A. Paul (1), A. Radtke (1), M. Malago (1), C. Broelsch (1) Abstract: Abstract Background: Caspofungin is the first substance of a new class of antifungal agents, the echinocandins that interfere with fungal cell wall synthesis by inhibition of glucan synthesis. Alanine aminotransferase (ALT) elevations were seen in phase I studies of patients receiving caspofungin and cyclosporine A (CyA). Actually, there is no information regarding hepatotoxicity in liver transplant patients treated concomitantly with caspofungin and immunosuppressant agents like CyA or tacrolimus (TAC). Patients and Methods: We conducted a retrospective study in 12 liver transplant patients (9 patients Child C, 3 patients acute liver failure) to assess the hepatic safety of simultaneous administration of caspofungin with CyA or TAC. Caspofungin was administered as first-line agent to patients for a 2-week period with either proofed invasive fungal infection (IFI) (n = 4), IFI-probable (n = 4), and IFI-possible (n = 4). All patients received concomitantly CyA or TAC as immunosuppressant agent. Results: Two patients died within the first 10 days after start of treatment, caused by gram-negative rods. All other ten patients completed the 14-day treatment period. No liver enzyme elevation was recorded in these patients and administration of caspofungin with CyA or TAC was well tolerated without hepatotoxicity. Conclusion: The concomitant use of caspofungin with CyA or TAC in liver transplant patients is safe and seemed to be without hepatotoxic effect. Author Affiliation: (1) Dept. of General Surgery and Transplantation, University Essen, Hufelandstr. 55, 45122, Essen, Germany (2) Institute of Medical Microbiology, University Essen, Essen, Germany Article History: Registration Date: 01/01/2006 Received Date: 15/11/2005 Accepted Date: 29/05/2006

Published
2006

45. Pancreaticoduodenectomy in octogenarians: a retrospective case-control study

Author

Attard, J., primary, Salinas, C Hidalgo, additional, Pathanki, A., additional, Roberts, K., additional, Sutcliffe, R., additional, Marudanayagam, R., additional, Muiesan, P., additional, Mirza, D., additional, Abradelo, M., additional, Dasari, B., additional, Isaac, J., additional, Davidson, B., additional, Sharma, D., additional, Imber, C., additional, Malago, M., additional, Rahman, Z., additional, Fusai, G., additional, and Chatzizacharias, N., additional

Published
2020
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46. Portal vein embolization before liver resection for perihilar cholangiocarcinoma reduces the risk of liver failure and perioperative mortality

Author

Olthof, P., primary, Koerkamp, B. Groot, additional, Jarnagin, W., additional, Aldrighetti, L., additional, Muiesan, P., additional, Troisi, R., additional, Malago, M., additional, Lang, H., additional, Alikhanov, R., additional, Guglielmi, A., additional, Malik, H., additional, Damink, S. Olde, additional, Sparrelid, E., additional, Pratschke, J., additional, and Van Gulik, T.M., additional

Published
2020
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