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3. The interplay between acute post-traumatic stress, depressive and anxiety symptoms on healthcare workers functioning during the COVID-19 emergency: A multicenter study comparing regions with increasing pandemic incidence

Author

Carmassi, Claudia, Dell'Oste, Valerio, Bui, Eric, Foghi, Claudia, Bertelloni, Carlo Antonio, Atti, Anna Rita, Buselli, Rodolfo, Di Paolo, Marco, Goracci, Arianna, Malacarne, Paolo, Nanni, Maria Giulia, Gesi, Camilla, Cerveri, Giancarlo, and Dell'Osso, Liliana

Published
2022
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4. Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study

Author

Rasulo, Frank A., Calza, Stefano, Robba, Chiara, Taccone, Fabio Silvio, Biasucci, Daniele G., Badenes, Rafael, Piva, Simone, Savo, Davide, Citerio, Giuseppe, Dibu, Jamil R., Curto, Francesco, Merciadri, Martina, Gritti, Paolo, Fassini, Paola, Park, Soojin, Lamperti, Massimo, Bouzat, Pierre, Malacarne, Paolo, Chieregato, Arturo, Bertuetti, Rita, Aspide, Raffaele, Cantoni, Alfredo, McCredie, Victoria, Guadrini, Lucrezia, and Latronico, Nicola

Published
2022
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5. High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial

Author

Garbero, Elena, Livigni, Sergio, Ferrari, Fiorenza, Finazzi, Stefano, Langer, Martin, Malacarne, Paolo, and Meca, Manlio Cosimo Claudio

Subjects
Mortality, Clinical trials -- Health aspects, Adsorption -- Health aspects, Septic shock -- Health aspects, Health care industry
Abstract

Purpose This study aimed at evaluating the efficacy and safety of high-dose (> 0.2 L/kg of treated plasma per day) coupled plasma filtration-adsorption (CPFA) in treating patients with septic shock. Methods Multicentre, randomised, adaptive trial, performed in 12 Italian intensive care units (ICUs). Patients aged 14 or more, admitted to the ICU with septic shock, or had developed it during the stay were eligible. The final outcome was mortality at discharge from the last hospital at which the patient received care. Results Between May 2015, and October 2017, 115 patients were randomised. The first interim analysis revealed a number of early deaths, prompting an unplanned analysis. Last hospital mortality was non-significantly higher in the CPFA (55.6%) than in the control group (46.2%, p = 0.35). The 90-day survival curves diverged in favour of the controls early after randomisation and remained separated afterwards (p = 0.100). An unplanned analysis showed higher mortality in CPFA compared to controls among patients without severe renal failure (p = 0.025); a dose-response relationship was observed between treated plasma volume and mortality (p = 0.010). Conclusion The COMPACT-2 trial was stopped due to the possible harmful effect of CPFA in patients with septic shock. The harmful effect, if present, was particularly marked in the early phase of septic shock. Patients not requiring renal replacement therapy seemed most exposed to the possible harm, with evidence of a dose-response effect. Until the mechanisms behind these results are fully understood, the use of CPFA for the treatment of patients with septic shock is not recommended., Author(s): Elena Garbero [sup.1], Sergio Livigni [sup.2], Fiorenza Ferrari [sup.3] [sup.4], Stefano Finazzi [sup.1], Martin Langer [sup.5], Paolo Malacarne [sup.6], Manlio Cosimo Claudio Meca [sup.7], Sabino Mosca [sup.2], Carlo Olivieri [...]

Published
2021
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6. A pandemic recap: lessons we have learned

Author

Coccolini, Federico, Cicuttin, Enrico, Cremonini, Camilla, Tartaglia, Dario, Viaggi, Bruno, Kuriyama, Akira, Picetti, Edoardo, Ball, Chad, Abu-Zidan, Fikri, Ceresoli, Marco, Turri, Bruno, Jain, Sumita, Palombo, Carlo, Guirao, Xavier, Rodrigues, Gabriel, Gachabayov, Mahir, Machado, Fernando, Eftychios, Lostoridis, Kanj, Souha S., Di Carlo, Isidoro, Di Saverio, Salomone, Khokha, Vladimir, Kirkpatrick, Andrew, Massalou, Damien, Forfori, Francesco, Corradi, Francesco, Delibegovic, Samir, Machain Vega, Gustavo M., Fantoni, Massimo, Demetriades, Demetrios, Kapoor, Garima, Kluger, Yoram, Ansari, Shamshul, Maier, Ron, Leppaniemi, Ari, Hardcastle, Timothy, Vereczkei, Andras, Karamagioli, Evika, Pikoulis, Emmanouil, Pistello, Mauro, Sakakushev, Boris E., Navsaria, Pradeep H., Galeiras, Rita, Yahya, Ali I., Osipov, Aleksei V., Dimitrov, Evgeni, Doklestić, Krstina, Pisano, Michele, Malacarne, Paolo, Carcoforo, Paolo, Sibilla, Maria Grazia, Kryvoruchko, Igor A., Bonavina, Luigi, Kim, Jae Il, Shelat, Vishal G., Czepiel, Jacek, Maseda, Emilio, Marwah, Sanjay, Chirica, Mircea, Biancofiore, Giandomenico, Podda, Mauro, Cobianchi, Lorenzo, Ansaloni, Luca, Fugazzola, Paola, Seretis, Charalampos, Gomez, Carlos Augusto, Tumietto, Fabio, Malbrain, Manu, Reichert, Martin, Augustin, Goran, Amato, Bruno, Puzziello, Alessandro, Hecker, Andreas, Gemignani, Angelo, Isik, Arda, Cucchetti, Alessandro, Nacoti, Mirco, Kopelman, Doron, Mesina, Cristian, Ghannam, Wagih, Ben-Ishay, Offir, Dhingra, Sameer, Coimbra, Raul, Moore, Ernest E., Cui, Yunfeng, Quiodettis, Martha A., Bala, Miklosh, Testini, Mario, Diaz, Jose, Girardis, Massimo, Biffl, Walter L., Hecker, Matthias, Sall, Ibrahima, Boggi, Ugo, Materazzi, Gabriele, Ghiadoni, Lorenzo, Matsumoto, Junichi, Zuidema, Wietse P., Ivatury, Rao, Enani, Mushira A., Litvin, Andrey, Al-Hasan, Majdi N., Demetrashvili, Zaza, Baraket, Oussama, Ordoñez, Carlos A., Negoi, Ionut, Kiguba, Ronald, Memish, Ziad A., Elmangory, Mutasim M., Tolonen, Matti, Das, Korey, Ribeiro, Julival, O’Connor, Donal B., Tan, Boun Kim, Van Goor, Harry, Baral, Suman, De Simone, Belinda, Corbella, Davide, Brambillasca, Pietro, Scaglione, Michelangelo, Basolo, Fulvio, De’Angelis, Nicola, Bendinelli, Cino, Weber, Dieter, Pagani, Leonardo, Monti, Cinzia, Baiocchi, Gianluca, Chiarugi, Massimo, Catena, Fausto, and Sartelli, Massimo

Published
2021
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9. Necrotizing Fasciitis and Diabetic Foot: Results of a Prompt Identification, Surgery and Antibiotic Therapy (P.I.S.A.) Protocol.

Author

Iacopi, Elisabetta, Sbarbaro, Catia, Pieruzzi, Letizia, Lorenzi, Irene, Baroni, Luisa, Goretti, Chiara, Malacarne, Paolo, and Piaggesi, Alberto

Abstract

Necrotizing fasciitis (NF) is a rapidly progressive, life-threatening infection, involving the skin, soft tissue and fascia. We evaluated outcomes of its surgical management in diabetic foot (DF) patients in a tertiary referral centre. We retrospectively searched for NF in the database of our DF Section from 2016 to 2018. All cases were treated according to a multiprofessional integrated protocol, with Prompt Identification, Surgical debridement and systemic Antibiotic therapy (P.I.S.A. Protocol). We analysed short-term evolution (surgical procedures and major amputations), and long-term outcomes (survival and healing rates). Sixty-eight patients were referred to our DF clinic for suspicion of NF. The diagnosis was confirmed in 54 (79.4%; male/female 40/14; type 1/2 diabetes 6/48; age 62.8 ± 8.1 years; duration of diabetes 13.6 ± 10.1 years). According to the microbiological results, cases were classified as Type 1 (33–61.2%), 2 (7−12.9%) and 3 (14–25.9%). No significant differences were observed. All patients underwent a decompressive fasciotomy. Six patients (11.1%) required also a forefoot amputation and 12 (22.2%) a toe or ray amputation. No major amputation was performed in the short-term period. During the follow-up (26 ± 12 months) 46 patients (85%) healed in 94 ± 11 days. Of the remaining 8: 5 (9.2%) died for other reasons before healing, 2 (3.7%) recurred and one (1.9%) required a major amputation. Our experience reveals a relatively high prevalence of NF in DF; despite this, we observed how, when promptly and aggressively treated, NF has a good prognosis and it is not associated with an excess of limb loss and deaths. [ABSTRACT FROM AUTHOR]

Published
2023
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10. A family information brochure and dedicated website to improve the ICU experience for patients’ relatives: an Italian multicenter before-and-after study

Author

Mistraletti, Giovanni, Umbrello, Michele, Mantovani, Elena Silvia, Moroni, Benedetta, Formenti, Paolo, Spanu, Paolo, Anania, Stefania, Andrighi, Elisa, Di Carlo, Alessandra, Martinetti, Federica, Vecchi, Irene, Palo, Alessandra, Pinna, Cristina, Russo, Riccarda, Francesconi, Silvia, Valdambrini, Federico, Ferretti, Enrica, Radeschi, Giulio, Bosco, Edda, Malacarne, Paolo, Iapichino, Gaetano, and The http://www.intensiva.it Investigators

Published
2017
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11. Colistin and Rifampicin Compared With Colistin Alone for the Treatment of Serious Infections Due to Extensively Drug-Resistant Acinetobacter baumannii: A Multicenter, Randomized Clinical Trial

Author

Durante-Mangoni, Emanuele, Signoriello, Giuseppe, Andini, Roberto, Mattei, Annunziata, De Cristoforo, Maria, Murino, Patrizia, Bassetti, Matteo, Malacarne, Paolo, Petrosillo, Nicola, Galdieri, Nicola, Mocavero, Paola, Corcione, Antonio, Viscoli, Claudio, Zarrilli, Raffaele, Gallo, Ciro, and Utili, Riccardo

Published
2013
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13. Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study

Author

Rasulo, F, Calza, S, Robba, C, Taccone, F, Biasucci, D, Badenes, R, Piva, S, Savo, D, Citerio, G, Dibu, J, Curto, F, Merciadri, M, Gritti, P, Fassini, P, Park, S, Lamperti, M, Bouzat, P, Malacarne, P, Chieregato, A, Bertuetti, R, Aspide, R, Cantoni, A, Mccredie, V, Guadrini, L, Latronico, N, Rasulo, Frank A., Calza, Stefano, Robba, Chiara, Taccone, Fabio Silvio, Biasucci, Daniele G., Badenes, Rafael, Piva, Simone, Savo, Davide, Citerio, Giuseppe, Dibu, Jamil R., Curto, Francesco, Merciadri, Martina, Gritti, Paolo, Fassini, Paola, Park, Soojin, Lamperti, Massimo, Bouzat, Pierre, Malacarne, Paolo, Chieregato, Arturo, Bertuetti, Rita, Aspide, Raffaele, Cantoni, Alfredo, McCredie, Victoria, Guadrini, Lucrezia, Latronico, Nicola, Rasulo, F, Calza, S, Robba, C, Taccone, F, Biasucci, D, Badenes, R, Piva, S, Savo, D, Citerio, G, Dibu, J, Curto, F, Merciadri, M, Gritti, P, Fassini, P, Park, S, Lamperti, M, Bouzat, P, Malacarne, P, Chieregato, A, Bertuetti, R, Aspide, R, Cantoni, A, Mccredie, V, Guadrini, L, Latronico, N, Rasulo, Frank A., Calza, Stefano, Robba, Chiara, Taccone, Fabio Silvio, Biasucci, Daniele G., Badenes, Rafael, Piva, Simone, Savo, Davide, Citerio, Giuseppe, Dibu, Jamil R., Curto, Francesco, Merciadri, Martina, Gritti, Paolo, Fassini, Paola, Park, Soojin, Lamperti, Massimo, Bouzat, Pierre, Malacarne, Paolo, Chieregato, Arturo, Bertuetti, Rita, Aspide, Raffaele, Cantoni, Alfredo, McCredie, Victoria, Guadrini, Lucrezia, and Latronico, Nicola

Abstract

Background: Alternative noninvasive methods capable of excluding intracranial hypertension through use of transcranial Doppler (ICPtcd) in situations where invasive methods cannot be used or are not available would be useful during the management of acutely brain-injured patients. The objective of this study was to determine whether ICPtcd can be considered a reliable screening test compared to the reference standard method, invasive ICP monitoring (ICPi), in excluding the presence of intracranial hypertension. Methods: This was a prospective, international, multicenter, unblinded, diagnostic accuracy study comparing the index test (ICPtcd) with a reference standard (ICPi), defined as the best available method for establishing the presence or absence of the condition of interest (i.e., intracranial hypertension). Acute brain-injured patients pertaining to one of four categories: traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH) or ischemic stroke (IS) requiring ICPi monitoring, were enrolled in 16 international intensive care units. ICPi measurements (reference test) were compared to simultaneous ICPtcd measurements (index test) at three different timepoints: before, immediately after and 2 to 3 h following ICPi catheter insertion. Sensitivity, specificity, positive (PPV) and negative predictive values (NPV) were calculated at three different ICPi thresholds (> 20, > 22 and > 25 mmHg) to assess ICPtcd as a bedside real-practice screening method. A receiver operating characteristic (ROC) curve analysis with the area under the curve (AUC) was used to evaluate the discriminative accuracy and predictive capability of ICPtcd. Results: Two hundred and sixty-two patients were recruited for final analysis. Intracranial hypertension (> 22 mmHg) occurred in 87 patients (33.2%). The total number of paired comparisons between ICPtcd and ICPi was 687. The NPV was elevated (ICP > 20 mmHg = 91.3%, > 22 mmHg = 95.6%, >

Published
2022

14. Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study

Author

Rasulo, Frank Anthony, Calza, Stefano, Robba, Chiara, Taccone, Fabio, Biasucci, Daniele Guerino, Badenes, Rafael, Piva, Simone, Savo, Davide, Citerio, Giuseppe, Dibu, Jamil J.R., Curto, Francesco, Merciadri, Martina, Gritti, Paolo, Fassini, Paola, Park, Soojin, Lamperti, Massimo, Bouzat, Pierre, Malacarne, Paolo, Chieregato, Arturo, Bertuetti, Rita, Aspide, Raffaele, Cantoni, Alfredo, McCredie, Victoria, Guadrini, Lucrezia, Latronico, Nicola, Rasulo, Frank Anthony, Calza, Stefano, Robba, Chiara, Taccone, Fabio, Biasucci, Daniele Guerino, Badenes, Rafael, Piva, Simone, Savo, Davide, Citerio, Giuseppe, Dibu, Jamil J.R., Curto, Francesco, Merciadri, Martina, Gritti, Paolo, Fassini, Paola, Park, Soojin, Lamperti, Massimo, Bouzat, Pierre, Malacarne, Paolo, Chieregato, Arturo, Bertuetti, Rita, Aspide, Raffaele, Cantoni, Alfredo, McCredie, Victoria, Guadrini, Lucrezia, and Latronico, Nicola

Abstract

Background: Alternative noninvasive methods capable of excluding intracranial hypertension through use of transcranial Doppler (ICPtcd) in situations where invasive methods cannot be used or are not available would be useful during the management of acutely brain-injured patients. The objective of this study was to determine whether ICPtcd can be considered a reliable screening test compared to the reference standard method, invasive ICP monitoring (ICPi), in excluding the presence of intracranial hypertension. Methods: This was a prospective, international, multicenter, unblinded, diagnostic accuracy study comparing the index test (ICPtcd) with a reference standard (ICPi), defined as the best available method for establishing the presence or absence of the condition of interest (i.e. intracranial hypertension). Acute brain-injured patients pertaining to one of four categories: traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH) or ischemic stroke (IS) requiring ICPi monitoring, were enrolled in 16 international intensive care units. ICPi measurements (reference test) were compared to simultaneous ICPtcd measurements (index test) at three different timepoints: before, immediately after and 2 to 3 h following ICPi catheter insertion. Sensitivity, specificity, positive (PPV) and negative predictive values (NPV) were calculated at three different ICPi thresholds (> 20, > 22 and > 25 mmHg) to assess ICPtcd as a bedside real-practice screening method. A receiver operating characteristic (ROC) curve analysis with the area under the curve (AUC) was used to evaluate the discriminative accuracy and predictive capability of ICPtcd. Results: Two hundred and sixty-two patients were recruited for final analysis. Intracranial hypertension (> 22 mmHg) occurred in 87 patients (33.2%). The total number of paired comparisons between ICPtcd and ICPi was 687. The NPV was elevated (ICP > 20 mmHg = 91.3%, > 22 mmHg = 95.6%, > 25 mmHg = 98.6%), indi, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

15. Additional file 3 of Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study

Author

Rasulo, Frank A., Calza, Stefano, Robba, Chiara, Taccone, Fabio Silvio, Biasucci, Daniele G., Badenes, Rafael, Piva, Simone, Savo, Davide, Citerio, Giuseppe, Dibu, Jamil R., Curto, Francesco, Merciadri, Martina, Gritti, Paolo, Fassini, Paola, Park, Soojin, Lamperti, Massimo, Bouzat, Pierre, Malacarne, Paolo, Chieregato, Arturo, Bertuetti, Rita, Aspide, Raffaele, Cantoni, Alfredo, McCredie, Victoria, Guadrini, Lucrezia, and Latronico, Nicola

Subjects
ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Data_FILES
Abstract

Additional file 3. Study Protocol.

Published
2022
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16. Additional file 4 of Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study

Author

Rasulo, Frank A., Calza, Stefano, Robba, Chiara, Taccone, Fabio Silvio, Biasucci, Daniele G., Badenes, Rafael, Piva, Simone, Savo, Davide, Citerio, Giuseppe, Dibu, Jamil R., Curto, Francesco, Merciadri, Martina, Gritti, Paolo, Fassini, Paola, Park, Soojin, Lamperti, Massimo, Bouzat, Pierre, Malacarne, Paolo, Chieregato, Arturo, Bertuetti, Rita, Aspide, Raffaele, Cantoni, Alfredo, McCredie, Victoria, Guadrini, Lucrezia, and Latronico, Nicola

Abstract

Additional file 4. Table S1. Number of measurements of invasive intracranial pressure (ICPi) and trans-cranial Doppler (TCD)-estimated ICP (ICPtcd) at the three time-frames (T1, T2 and T3) in relation to the three ICP different thresholds (> 20 mmHg, > 22 mmHg and > 25 mmHg).

Published
2022
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17. Additional file 7 of Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study

Author

Rasulo, Frank A., Calza, Stefano, Robba, Chiara, Taccone, Fabio Silvio, Biasucci, Daniele G., Badenes, Rafael, Piva, Simone, Savo, Davide, Citerio, Giuseppe, Dibu, Jamil R., Curto, Francesco, Merciadri, Martina, Gritti, Paolo, Fassini, Paola, Park, Soojin, Lamperti, Massimo, Bouzat, Pierre, Malacarne, Paolo, Chieregato, Arturo, Bertuetti, Rita, Aspide, Raffaele, Cantoni, Alfredo, McCredie, Victoria, Guadrini, Lucrezia, and Latronico, Nicola

Abstract

Additional file 7. Figure S3. Bland-Altman analysis for each time frame.

Published
2022
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18. Additional file 5 of Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study

Author

Rasulo, Frank A., Calza, Stefano, Robba, Chiara, Taccone, Fabio Silvio, Biasucci, Daniele G., Badenes, Rafael, Piva, Simone, Savo, Davide, Citerio, Giuseppe, Dibu, Jamil R., Curto, Francesco, Merciadri, Martina, Gritti, Paolo, Fassini, Paola, Park, Soojin, Lamperti, Massimo, Bouzat, Pierre, Malacarne, Paolo, Chieregato, Arturo, Bertuetti, Rita, Aspide, Raffaele, Cantoni, Alfredo, McCredie, Victoria, Guadrini, Lucrezia, and Latronico, Nicola

Abstract

Additional file 5. Figure S2. Forest plot indicating the areas under a curve (AUC), sensitivity and specificity for each time frame (T1, T2, T3).

Published
2022
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19. Additional file 2 of Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study

Author

Rasulo, Frank A., Calza, Stefano, Robba, Chiara, Taccone, Fabio Silvio, Biasucci, Daniele G., Badenes, Rafael, Piva, Simone, Savo, Davide, Citerio, Giuseppe, Dibu, Jamil R., Curto, Francesco, Merciadri, Martina, Gritti, Paolo, Fassini, Paola, Park, Soojin, Lamperti, Massimo, Bouzat, Pierre, Malacarne, Paolo, Chieregato, Arturo, Bertuetti, Rita, Aspide, Raffaele, Cantoni, Alfredo, McCredie, Victoria, Guadrini, Lucrezia, and Latronico, Nicola

Abstract

Additional file 2. Figure S1. Total number of patients recruited per center.

Published
2022
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20. Additional file 8 of Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study

Author

Rasulo, Frank A., Calza, Stefano, Robba, Chiara, Taccone, Fabio Silvio, Biasucci, Daniele G., Badenes, Rafael, Piva, Simone, Savo, Davide, Citerio, Giuseppe, Dibu, Jamil R., Curto, Francesco, Merciadri, Martina, Gritti, Paolo, Fassini, Paola, Park, Soojin, Lamperti, Massimo, Bouzat, Pierre, Malacarne, Paolo, Chieregato, Arturo, Bertuetti, Rita, Aspide, Raffaele, Cantoni, Alfredo, McCredie, Victoria, Guadrini, Lucrezia, and Latronico, Nicola

Subjects
nervous system, nervous system diseases
Abstract

Additional file 8. Table S3. Comparison of relevant clinical variables (CPP, TBI vs non-TBI and GCS) in patients with concordant or discordant ICPi and ICPtcd readings at the three ICPi thresholds, (20, 22 and 25 mmHg).CPP showed lower values in the False Negatives and higher values in False Positives compared to Concordant readings. All measurements considered the average value over the the three time-frames (T1–3).

Published
2022
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21. Additional file 1 of Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study

Author

Rasulo, Frank A., Calza, Stefano, Robba, Chiara, Taccone, Fabio Silvio, Biasucci, Daniele G., Badenes, Rafael, Piva, Simone, Savo, Davide, Citerio, Giuseppe, Dibu, Jamil R., Curto, Francesco, Merciadri, Martina, Gritti, Paolo, Fassini, Paola, Park, Soojin, Lamperti, Massimo, Bouzat, Pierre, Malacarne, Paolo, Chieregato, Arturo, Bertuetti, Rita, Aspide, Raffaele, Cantoni, Alfredo, McCredie, Victoria, Guadrini, Lucrezia, and Latronico, Nicola

Abstract

Additional file 1. STARD checklist.

Published
2022
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24. SARS-CoV-2 management in Emergency Department: risk stratification and care setting identification proposal based on first pandemic wave in Pisa University Hospital

Author

Barbieri, Greta, primary, Cipriano, Alessandro, additional, Carrara, Stella, additional, Spinelli, Stefano, additional, Cinotti, Francesco, additional, Foltran, Francesca, additional, Filippi, Matteo, additional, Aquilini, Ferruccio, additional, Tonerini, Michele, additional, Santini, Massimo, additional, Malacarne, Paolo, additional, and Ghiadoni, Lorenzo, additional

Published
2021
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27. A pandemic recap: lessons we have learned

Author

Coccolini, Federico Cicuttin, Enrico Cremonini, Camilla and Tartaglia, Dario Viaggi, Bruno Kuriyama, Akira Picetti, Edoardo Ball, Chad Abu-Zidan, Fikri Ceresoli, Marco and Turri, Bruno Jain, Sumita Palombo, Carlo Guirao, Xavier and Rodrigues, Gabriel Gachabayov, Mahir Machado, Fernando and Eftychios, Lostoridis Kanj, Souha S. Di Carlo, Isidoro Di Saverio, Salomone Khokha, Vladimir Kirkpatrick, Andrew and Massalou, Damien Forfori, Francesco Corradi, Francesco and Delibegovic, Samir Machain Vega, Gustavo M. Fantoni, Massimo and Demetriades, Demetrios Kapoor, Garima Kluger, Yoram Ansari, Shamshul Maier, Ron Leppaniemi, Ari Hardcastle, Timothy and Vereczkei, Andras Karamagioli, Evika Pikoulis, Emmanouil and Pistello, Mauro Sakakushev, Boris E. Navsaria, Pradeep H. and Galeiras, Rita Yahya, Ali I. Osipov, Aleksei V. Dimitrov, Evgeni Doklestic, Krstina Pisano, Michele Malacarne, Paolo and Carcoforo, Paolo Sibilla, Maria Grazia Kryvoruchko, Igor A. and Bonavina, Luigi Kim, Jae Il Shelat, Vishal G. Czepiel, Jacek Maseda, Emilio Marwah, Sanjay Chirica, Mircea and Biancofiore, Giandomenico Podda, Mauro Cobianchi, Lorenzo and Ansaloni, Luca Fugazzola, Paola Seretis, Charalampos Gomez, Carlos Augusto Tumietto, Fabio Malbrain, Manu Reichert, Martin Augustin, Goran Amato, Bruno Puzziello, Alessandro and Hecker, Andreas Gemignani, Angelo Isik, Arda Cucchetti, Alessandro Nacoti, Mirco Kopelman, Doron Mesina, Cristian and Ghannam, Wagih Ben-Ishay, Offir Dhingra, Sameer Coimbra, Raul Moore, Ernest E. Cui, Yunfeng Quiodettis, Martha A. and Bala, Miklosh Testini, Mario Diaz, Jose Girardis, Massimo and Biffl, Walter L. Hecker, Matthias Sall, Ibrahima Boggi, Ugo Materazzi, Gabriele Ghiadoni, Lorenzo Matsumoto, Junichi and Zuidema, Wietse P. Ivatury, Rao Enani, Mushira A. and Litvin, Andrey Al-Hasan, Majdi N. Demetrashvili, Zaza and Baraket, Oussama Ordonez, Carlos A. Negoi, Ionut Kiguba, Ronald Memish, Ziad A. Elmangory, Mutasim M. Tolonen, Matti and Das, Korey Ribeiro, Julival O'Connor, Donal B. Tan, Boun Kim Van Goor, Harry Baral, Suman De Simone, Belinda and Corbella, Davide Brambillasca, Pietro Scaglione, Michelangelo and Basolo, Fulvio De'Angelis, Nicola Bendinelli, Cino and Weber, Dieter Pagani, Leonardo Monti, Cinzia Baiocchi, Gianluca Chiarugi, Massimo Catena, Fausto Sartelli, Massimo

Abstract

On January 2020, the WHO Director General declared that the outbreak constitutes a Public Health Emergency of International Concern. The world has faced a worldwide spread crisis and is still dealing with it. The present paper represents a white paper concerning the tough lessons we have learned from the COVID-19 pandemic. Thus, an international and heterogenous multidisciplinary panel of very differentiated people would like to share global experiences and lessons with all interested and especially those responsible for future healthcare decision making. With the present paper, international and heterogenous multidisciplinary panel of very differentiated people would like to share global experiences and lessons with all interested and especially those responsible for future healthcare decision making.

Published
2021

28. Additional file 1 of Why and how to open intensive care units to family visits during the pandemic

Author

Mistraletti, Giovanni, Giannini, Alberto, Gristina, Giuseppe, Malacarne, Paolo, Mazzon, Davide, Cerutti, Elisabetta, Galazzi, Alessandro, Giubbilo, Ilaria, Vergano, Marco, Zagrebelsky, Vladimiro, Riccioni, Luigi, Grasselli, Giacomo, Scelsi, Silvia, Cecconi, Maurizio, and Petrini, Flavia

Abstract

Additional file 1. Presentation of the social, relational, and organizational challenges due to the pandemic, together with a description of the Authors’ group.

Published
2021
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34. Liver trauma: WSES 2020 guidelines

Author

Coccolini, Federico Coimbra, Raul Ordonez, Carlos Kluger, Yoram Vega, Felipe Moore, Ernest E. Biffl, Walt and Peitzman, Andrew Horer, Tal Abu-Zidan, Fikri M. Sartelli, Massimo Fraga, Gustavo P. Cicuttin, Enrico Ansaloni, Luca and Parra, Michael W. Millan, Mauricio DeAngelis, Nicola and Inaba, Kenji Velmahos, George Maier, Ron Khokha, Vladimir and Sakakushev, Boris Augustin, Goran di Saverio, Salomone and Pikoulis, Emanuil Chirica, Mircea Reva, Viktor Leppaniemi, Ari Manchev, Vassil Chiarugi, Massimo Damaskos, Dimitrios and Weber, Dieter Parry, Neil Demetrashvili, Zaza Civil, Ian and Napolitano, Lena Corbella, Davide Catena, Fausto and Bahouth, Hany Bahouth, Hany Tolonen, Matti Fugazzola, Paola and Serna, Jose Julian Rodriguez, Fernando Garcia, Alberto F. and Gonzalez, Adolfo Pino, Luis Fernando Guzman-Rodriguez, Monica Pereira, Bruno M. Kirkpatrick, Andrew Mefire, Alain Chichom Tarasconi, Antonio Chiara, Osvaldo Gomes, Carlos Augusto Galante, Joseph Bala, Miklosh Perfetti, Paola and Machado, Fernando Romeo, Oreste Salvetti, Francesco and Ghiadoni, Lorenzo Forfori, Francesco Malacarne, Paolo Pini, Silvia Pucciarelli, Marsia Ceresoli, Marco Arvieux, Catherine Khokha, Denis Spain, David A. Isik, Arda WSES Expert Panel

Abstract

Liver injuries represent one of the most frequent life-threatening injuries in trauma patients. In determining the optimal management strategy, the anatomic injury, the hemodynamic status, and the associated injuries should be taken into consideration. Liver trauma approach may require non-operative or operative management with the intent to restore the homeostasis and the normal physiology. The management of liver trauma should be multidisciplinary including trauma surgeons, interventional radiologists, and emergency and ICU physicians. The aim of this paper is to present the World Society of Emergency Surgery (WSES) liver trauma management guidelines.

Published
2020

35. Trans-Cranial Doppler as a Screening Test to Exclude Intracranial Hypertension in Brain Injured Patients: The IMPRESSIT-2 Prospective Multicenter International Study

Author

Rasulo, Frank Anthony, primary, Calza, Stefano, additional, Robba, Chiara, additional, Taccone, Fabio Silvio, additional, Biasucci, Daniele G., additional, Badenes, Rafael, additional, Piva, Simone, additional, Savo, Davide, additional, Citerio, Giuseppe, additional, Dibu, Jamil R., additional, Curto, Francesco, additional, Merciadri, Martina, additional, Gritti, Paolo, additional, Fassini, Paola, additional, Park, Soojin, additional, Lamperti, Massimo, additional, Bouzat, Pierre, additional, Malacarne, Paolo, additional, Chieregato, Arturo, additional, Bertuetti, Rita, additional, Aspide, Raffaele, additional, Cantoni, Alfredo, additional, McCredie, Victoria, additional, Guadrini, Lucrezia, additional, and Latronico, Nicola, additional

Published
2021
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38. Cefiderocol as Rescue Therapy for Acinetobacter baumannii and Other Carbapenem-resistant Gram-negative Infections in Intensive Care Unit Patients

Author

Falcone, Marco, primary, Tiseo, Giusy, additional, Nicastro, Manuela, additional, Leonildi, Alessandro, additional, Vecchione, Alessandra, additional, Casella, Costanza, additional, Forfori, Francesco, additional, Malacarne, Paolo, additional, Guarracino, Fabio, additional, Barnini, Simona, additional, and Menichetti, Francesco, additional

Published
2020
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39. Effect of a Lung Protective Strategy for Organ Donors on Eligibility and Availability of Lungs for Transplantation: A Randomized Controlled Trial

Author

Mascia, Luciana, Pasero, Daniela, Slutsky, Arthur S., Arguis, M. Jose, Berardino, Maurizio, Grasso, Salvatore, Munari, Marina, Boifava, Silvia, Cornara, Giuseppe, Della Corte, Francesco, Vivaldi, Nicoletta, Malacarne, Paolo, Del Gaudio, Paolo, Livigni, Sergio, Zavala, Elisabeth, Filippini, Claudia, Martin, Erica L., Donadio, Pier Paolo, Mastromauro, Ilaria, and Ranieri, V. Marco

Published
2010
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46. Cefiderocol as Rescue Therapy for Acinetobacter baumannii and Other Carbapenem-resistant Gram-negative Infections in Intensive Care Unit Patients.

Author

Falcone, Marco, Tiseo, Giusy, Nicastro, Manuela, Leonildi, Alessandro, Vecchione, Alessandra, Casella, Costanza, Forfori, Francesco, Malacarne, Paolo, Guarracino, Fabio, Barnini, Simona, and Menichetti, Francesco

Subjects
INTENSIVE care units, ACINETOBACTER infections, CROSS infection, CEPHALOSPORINS, MASS spectrometry, GENES, DESCRIPTIVE statistics, GRAM-negative bacterial diseases, POLYMERASE chain reaction, DRUG resistance in microorganisms, PHARMACODYNAMICS
Abstract

Ten critically ill patients with either bacteremia or ventilator-associated pneumonia caused by carbapenem-resistant Acinetobacter baumannii , Stenotrophomonas maltophilia , or New Delhi metallo-β-lactamase–producing Klebsiella pneumoniae received cefiderocol. All strains had minimum inhibitory concentration ≤2 μg/mL. Thirty-day clinical success and survival rates were 70% and 90%, respectively. Two patients had a microbiological failure. Future prospective studies are warranted. [ABSTRACT FROM AUTHOR]

Published
2021
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48. Improving Cleaning and Disinfection of High-Touch Surfaces in Intensive Care during Carbapenem-Resistant Acinetobacter baumannii Endemo-Epidemic Situations

Author

Casini, Beatrice, primary, Righi, Anna, additional, De Feo, Nunzio, additional, Totaro, Michele, additional, Giorgi, Serena, additional, Zezza, Lavinia, additional, Valentini, Paola, additional, Tagliaferri, Enrico, additional, Costa, Anna, additional, Barnini, Simona, additional, Baggiani, Angelo, additional, Lopalco, Pietro, additional, Malacarne, Paolo, additional, and Privitera, Gaetano, additional

Published
2018
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