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1. Risk loci involved in giant cell arteritis susceptibility: a genome-wide association study

Author

Callejas, José Luis, Caminal-Montero, Luis, Corbera-Bellalta, Marc, de Miguel, Eugenio, Díaz-López, J. Bernardino, García-Villanueva, María Jesús, Gómez-Vaquero, Carmen, Guijarro-Rojas, Mercedes, Hidalgo-Conde, Ana, Marí-Alfonso, Begoña, Martínez-Berriochoa, Agustín, Morado, Inmaculada C., Narváez, Javier, Ramentol-Sintas, Marc, Martínez-Zapico, Aleida, Martínez-Taboada, Víctor Manuel, Miranda-Filloy, José A., Monfort, Jordi, Pérez-Conesa, Mercedes, Prieto-González, Sergio, Raya, Enrique, Ríos-Fenández, Raquel, Sánchez-Martín, Julio, Sopeña, Bernardo, Tío, Laura, Unzurrunzaga, Ainhoa, Wordsworth, Oliver, Whitwell, Isobel, Brock, Jessica, Douglas, Victoria, Hettiarachchi, Chamila, Bartholomew, Jacqui, Jarrett, Stephen, Smithson, Gayle, Green, Michael, Brown, Pearl Clark, Lawson, Cathy, Gordon, Esther, Lane, Suzanne, Francis, Rebecca, Dasgupta, Bhaskar, Masunda, Bridgett, Calver, Jo, Patel, Yusuf, Thompson, Charlotte, Gregory, Louise, Levy, Sarah, Menon, Ajit, Thompson, Amy, Dyche, Lisa, Martin, Michael, Li, Charles, Laxminarayan, Ramasharan, Wilcox, Louise, de Guzman, Ralph, Isaacs, John, Lorenzi, Alice, Farley, Ross, Hinchcliffe-Hume, Helain, Bejarano, Victoria, Hope, Susan, Nandi, Pradip, Stockham, Lynne, Wilde, Catherine, Durrant, Donna, Lloyd, Mark, Ye, Chee-Seng, Stevens, Rob, Jilani, Amjad, Collins, David, Pegler, Suzannah, Rivett, Ali, Price, Liz, McHugh, Neil, Skeoch, Sarah, O'Kane, Diana, Kirkwood, Sue, Vadivelu, Saravanan, Pugmire, Susan, Sultan, Shabina, Dooks, Emma, Armstrong, Lisa, Sadik, Hala, Nandagudi, Anupama, Abioye, Tolu, Ramos, Angelo, Gumus, Steph, Sofat, Nidhi, Harrison, Abiola, Seward, Abi, Mollan, Susan, Rahan, Ray, Hawkins, Helen, Emsley, Hedley, Bhargava, Anna, Fleming, Vicki, Hare, Marianne, Raj, Sonia, George, Emmanuel, Allen, Nicola, Hunter, Karl, O'Sullivan, Eoin, Bird, Georgina, Magliano, Malgorzata, Manzo, Katarina, Sanghera, Bobbie, Hutchinson, David, Hammonds, Fiona, Sharma, Poonam, Cooper, Richard, McLintock, Graeme, Al-Saffar, Zaid S., Green, Mike, Elliott, Kerry, Neale, Tania, Mallinson, Janine, Lanyon, Peter, Pradere, Marie-Josephe, Jordan, Natasha, Htut, Ei Phyu, Mushapaidzi, Thelma, Abercrombie, Donna, Wright, Sam, Rowlands, Jane, Mukhtyar, Chetan, Kennedy, James, Makkuni, Damodar, Wilhelmsen, Elva, Kouroupis, Michael, John, Lily, Hughes, Rod, Walsh, Margaret, Buckley, Marie, Mackay, Kirsten, Camden-Woodley, Tracey, Redome, Joan, Pearce, Kirsty, Marianayagam, Thiraupathy, Cruz, Carina, Warner, Elizabeth, Atchia, Ishmael, Walker, Claire, Black, Karen, Duffy, Stacey, Fothergill, Lynda, Jefferey, Rebecca, Toomey, Jackie, Rhys-Dillon, Ceril, Pothecary, Carla, Green, Lauren, Toms, Tracey, Maher, Linda, Davis, Diana, Sayan, Amrinder, Thankachen, Mini, Abusalameh, Mahdi, Record, Jessica, Khan, Asad, Stafford, Sam, Hussein, Azza, Williams, Clare, Fletcher, Alison, Johson, Laura, Burnett, Richard, Moots, Robert, Frankland, Helen, Dale, James, Moar, Kirsten, Hollas, Carol, Parker, Ben, Ridings, Derek, Eapen, Sandhya, John, Sindhu, Robson, Jo, Guthrie, Lucy Belle, Fyfe, Rose, Tait, Moira, Marks, Jonathan, Gunter, Emma, Hernandez, Rochelle, Bhat, Smita, Johnston, Paul, Khurshid, Muhammad, Barclay, Charlotte, Kapur, Deepti, Jeffrey, Helen, Hughes, Anna, Slack, Lauren, Thomas, Eleri, Royon, Anna, Hall, Angela, King, Jon, Nyathi, Sindi, Morris, Vanessa, Castelino, Madhura, Hawkins, Ellie, Tomson, Linda, Singh, Animesh, Nunag, Annalyn, O'Connor, Stella, Rushby, Nathan, Hewitson, Nicola, O'Sunmboye, Kenny, Lewszuk, Adam, Boyles, Louise, Perry, Martin, Williams, Emma, Graver, Christine, Defever, Emmanuel, Kamanth, Sanjeet, Kay, Dominic, Ogor, Joe, Winter, Louise, Horton, Sarah, Welch, Gillian, Hollinshead, Kath, Peters, James, Labao, Julius, Dmello, Andrea, Dawson, Julie, Graham, Denise, De Lord, Denise, Deery, Jo, Hazelton, Tracy, Carette, Simon, Chung, Sharon, Cuthbertson, David, Forbess, Lindsy J., Gewurz-Singer, Ora, Hoffman, Gary S., Koening, Curry L., Maksimowicz-McKinnon, Kathleen M., McAlear, Carol A., Moreland, Larry W., Pagnoux, Christian, Seo, Philip, Specks, Ulrich, Spiera, Robert F., Sreih, Antoine, Warrington, Kenneth J., Monach, Paul A., Weisman, Michael, Borrego-Yaniz, Gonzalo, Ortiz-Fernández, Lourdes, Madrid-Paredes, Adela, Kerick, Martin, Hernández-Rodríguez, José, Mackie, Sarah L, Vaglio, Augusto, Castañeda, Santos, Solans, Roser, Mestre-Torres, Jaume, Khalidi, Nader, Langford, Carol A, Ytterberg, Steven, Beretta, Lorenzo, Govoni, Marcello, Emmi, Giacomo, Cimmino, Marco A, Witte, Torsten, Neumann, Thomas, Holle, Julia, Schönau, Verena, Pugnet, Gregory, Papo, Thomas, Haroche, Julien, Mahr, Alfred, Mouthon, Luc, Molberg, Øyvind, Diamantopoulos, Andreas P, Voskuyl, Alexandre, Daikeler, Thomas, Berger, Christoph T, Molloy, Eamonn S, Blockmans, Daniel, van Sleen, Yannick, Iles, Mark, Sorensen, Louise, Luqmani, Raashid, Reynolds, Gary, Bukhari, Marwan, Bhagat, Shweta, Ortego-Centeno, Norberto, Brouwer, Elisabeth, Lamprecht, Peter, Klapa, Sebastian, Salvarani, Carlo, Merkel, Peter A, Cid, María C, González-Gay, Miguel A, Morgan, Ann W, Martin, Javier, and Márquez, Ana

Published
2024
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2. Risk loci involved in giant cell arteritis susceptibility: a genome-wide association study

Author

Borrego-Yaniz, Gonzalo, primary, Ortiz-Fernández, Lourdes, additional, Madrid-Paredes, Adela, additional, Kerick, Martin, additional, Hernández-Rodríguez, José, additional, Mackie, Sarah L, additional, Vaglio, Augusto, additional, Castañeda, Santos, additional, Solans, Roser, additional, Mestre-Torres, Jaume, additional, Khalidi, Nader, additional, Langford, Carol A, additional, Ytterberg, Steven, additional, Beretta, Lorenzo, additional, Govoni, Marcello, additional, Emmi, Giacomo, additional, Cimmino, Marco A, additional, Witte, Torsten, additional, Neumann, Thomas, additional, Holle, Julia, additional, Schönau, Verena, additional, Pugnet, Gregory, additional, Papo, Thomas, additional, Haroche, Julien, additional, Mahr, Alfred, additional, Mouthon, Luc, additional, Molberg, Øyvind, additional, Diamantopoulos, Andreas P, additional, Voskuyl, Alexandre, additional, Daikeler, Thomas, additional, Berger, Christoph T, additional, Molloy, Eamonn S, additional, Blockmans, Daniel, additional, van Sleen, Yannick, additional, Iles, Mark, additional, Sorensen, Louise, additional, Luqmani, Raashid, additional, Reynolds, Gary, additional, Bukhari, Marwan, additional, Bhagat, Shweta, additional, Ortego-Centeno, Norberto, additional, Brouwer, Elisabeth, additional, Lamprecht, Peter, additional, Klapa, Sebastian, additional, Salvarani, Carlo, additional, Merkel, Peter A, additional, Cid, María C, additional, González-Gay, Miguel A, additional, Morgan, Ann W, additional, Martin, Javier, additional, Márquez, Ana, additional, Callejas, José Luis, additional, Caminal-Montero, Luis, additional, Corbera-Bellalta, Marc, additional, de Miguel, Eugenio, additional, Díaz-López, J. Bernardino, additional, García-Villanueva, María Jesús, additional, Gómez-Vaquero, Carmen, additional, Guijarro-Rojas, Mercedes, additional, Hidalgo-Conde, Ana, additional, Marí-Alfonso, Begoña, additional, Martínez-Berriochoa, Agustín, additional, Morado, Inmaculada C., additional, Narváez, Javier, additional, Ramentol-Sintas, Marc, additional, Martínez-Zapico, Aleida, additional, Martínez-Taboada, Víctor Manuel, additional, Miranda-Filloy, José A., additional, Monfort, Jordi, additional, Pérez-Conesa, Mercedes, additional, Prieto-González, Sergio, additional, Raya, Enrique, additional, Ríos-Fenández, Raquel, additional, Sánchez-Martín, Julio, additional, Sopeña, Bernardo, additional, Tío, Laura, additional, Unzurrunzaga, Ainhoa, additional, Wordsworth, Oliver, additional, Whitwell, Isobel, additional, Brock, Jessica, additional, Douglas, Victoria, additional, Hettiarachchi, Chamila, additional, Bartholomew, Jacqui, additional, Jarrett, Stephen, additional, Smithson, Gayle, additional, Green, Michael, additional, Brown, Pearl Clark, additional, Lawson, Cathy, additional, Gordon, Esther, additional, Lane, Suzanne, additional, Francis, Rebecca, additional, Dasgupta, Bhaskar, additional, Masunda, Bridgett, additional, Calver, Jo, additional, Patel, Yusuf, additional, Thompson, Charlotte, additional, Gregory, Louise, additional, Levy, Sarah, additional, Menon, Ajit, additional, Thompson, Amy, additional, Dyche, Lisa, additional, Martin, Michael, additional, Li, Charles, additional, Laxminarayan, Ramasharan, additional, Wilcox, Louise, additional, de Guzman, Ralph, additional, Isaacs, John, additional, Lorenzi, Alice, additional, Farley, Ross, additional, Hinchcliffe-Hume, Helain, additional, Bejarano, Victoria, additional, Hope, Susan, additional, Nandi, Pradip, additional, Stockham, Lynne, additional, Wilde, Catherine, additional, Durrant, Donna, additional, Lloyd, Mark, additional, Ye, Chee-Seng, additional, Stevens, Rob, additional, Jilani, Amjad, additional, Collins, David, additional, Pegler, Suzannah, additional, Rivett, Ali, additional, Price, Liz, additional, McHugh, Neil, additional, Skeoch, Sarah, additional, O'Kane, Diana, additional, Kirkwood, Sue, additional, Vadivelu, Saravanan, additional, Pugmire, Susan, additional, Sultan, Shabina, additional, Dooks, Emma, additional, Armstrong, Lisa, additional, Sadik, Hala, additional, Nandagudi, Anupama, additional, Abioye, Tolu, additional, Ramos, Angelo, additional, Gumus, Steph, additional, Sofat, Nidhi, additional, Harrison, Abiola, additional, Seward, Abi, additional, Mollan, Susan, additional, Rahan, Ray, additional, Hawkins, Helen, additional, Emsley, Hedley, additional, Bhargava, Anna, additional, Fleming, Vicki, additional, Hare, Marianne, additional, Raj, Sonia, additional, George, Emmanuel, additional, Allen, Nicola, additional, Hunter, Karl, additional, O'Sullivan, Eoin, additional, Bird, Georgina, additional, Magliano, Malgorzata, additional, Manzo, Katarina, additional, Sanghera, Bobbie, additional, Hutchinson, David, additional, Hammonds, Fiona, additional, Sharma, Poonam, additional, Cooper, Richard, additional, McLintock, Graeme, additional, Al-Saffar, Zaid S., additional, Green, Mike, additional, Elliott, Kerry, additional, Neale, Tania, additional, Mallinson, Janine, additional, Lanyon, Peter, additional, Pradere, Marie-Josephe, additional, Jordan, Natasha, additional, Htut, Ei Phyu, additional, Mushapaidzi, Thelma, additional, Abercrombie, Donna, additional, Wright, Sam, additional, Rowlands, Jane, additional, Mukhtyar, Chetan, additional, Kennedy, James, additional, Makkuni, Damodar, additional, Wilhelmsen, Elva, additional, Kouroupis, Michael, additional, John, Lily, additional, Hughes, Rod, additional, Walsh, Margaret, additional, Buckley, Marie, additional, Mackay, Kirsten, additional, Camden-Woodley, Tracey, additional, Redome, Joan, additional, Pearce, Kirsty, additional, Marianayagam, Thiraupathy, additional, Cruz, Carina, additional, Warner, Elizabeth, additional, Atchia, Ishmael, additional, Walker, Claire, additional, Black, Karen, additional, Duffy, Stacey, additional, Fothergill, Lynda, additional, Jefferey, Rebecca, additional, Toomey, Jackie, additional, Rhys-Dillon, Ceril, additional, Pothecary, Carla, additional, Green, Lauren, additional, Toms, Tracey, additional, Maher, Linda, additional, Davis, Diana, additional, Sayan, Amrinder, additional, Thankachen, Mini, additional, Abusalameh, Mahdi, additional, Record, Jessica, additional, Khan, Asad, additional, Stafford, Sam, additional, Hussein, Azza, additional, Williams, Clare, additional, Fletcher, Alison, additional, Johson, Laura, additional, Burnett, Richard, additional, Moots, Robert, additional, Frankland, Helen, additional, Dale, James, additional, Moar, Kirsten, additional, Hollas, Carol, additional, Parker, Ben, additional, Ridings, Derek, additional, Eapen, Sandhya, additional, John, Sindhu, additional, Robson, Jo, additional, Guthrie, Lucy Belle, additional, Fyfe, Rose, additional, Tait, Moira, additional, Marks, Jonathan, additional, Gunter, Emma, additional, Hernandez, Rochelle, additional, Bhat, Smita, additional, Johnston, Paul, additional, Khurshid, Muhammad, additional, Barclay, Charlotte, additional, Kapur, Deepti, additional, Jeffrey, Helen, additional, Hughes, Anna, additional, Slack, Lauren, additional, Thomas, Eleri, additional, Royon, Anna, additional, Hall, Angela, additional, King, Jon, additional, Nyathi, Sindi, additional, Morris, Vanessa, additional, Castelino, Madhura, additional, Hawkins, Ellie, additional, Tomson, Linda, additional, Singh, Animesh, additional, Nunag, Annalyn, additional, O'Connor, Stella, additional, Rushby, Nathan, additional, Hewitson, Nicola, additional, O'Sunmboye, Kenny, additional, Lewszuk, Adam, additional, Boyles, Louise, additional, Perry, Martin, additional, Williams, Emma, additional, Graver, Christine, additional, Defever, Emmanuel, additional, Kamanth, Sanjeet, additional, Kay, Dominic, additional, Ogor, Joe, additional, Winter, Louise, additional, Horton, Sarah, additional, Welch, Gillian, additional, Hollinshead, Kath, additional, Peters, James, additional, Labao, Julius, additional, Dmello, Andrea, additional, Dawson, Julie, additional, Graham, Denise, additional, De Lord, Denise, additional, Deery, Jo, additional, Hazelton, Tracy, additional, Carette, Simon, additional, Chung, Sharon, additional, Cuthbertson, David, additional, Forbess, Lindsy J., additional, Gewurz-Singer, Ora, additional, Hoffman, Gary S., additional, Koening, Curry L., additional, Maksimowicz-McKinnon, Kathleen M., additional, McAlear, Carol A., additional, Moreland, Larry W., additional, Pagnoux, Christian, additional, Seo, Philip, additional, Specks, Ulrich, additional, Spiera, Robert F., additional, Sreih, Antoine, additional, Warrington, Kenneth J., additional, Monach, Paul A., additional, and Weisman, Michael, additional

Published
2024
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5. Mortality and adverse events of special interest with intravenous belimumab for adults with active, autoantibody-positive systemic lupus erythematosus (BASE): a multicentre, double-blind, randomised, placebo-controlled, phase 4 trial

Author

Sheikh, Saira Z, Scheinberg, Morton A, Wei, James Cheng-Chung, Tegzova, Dana, Stohl, William, de Toledo, Ricardo Acayaba, Mucenic, Tamara, Banfi, Mauricio R Abello, Maksimowicz-McKinnon, Kathleen, Abud-Mendoza, Carlos, Navarra, Sandra, Garcia, Mercedes, Garcia-De La Torre, Ignacio, Ros, Josep Ordi, Levy, Roger A, Bass, Damon L, Terrés, Jorge Ross, Punwaney, Raj, Harris, Julia, Nami, Alireza, Pierce, Amy, Thorneloe, Kevin S, Ji, Beulah, and Roth, David A

Published
2021
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9. Phase III / IV , Randomized, Fifty‐Two –Week Study of the Efficacy and Safety of Belimumab in Patients of Black African Ancestry With Systemic Lupus Erythematosus

Author

Ginzler, Ellen, primary, Guedes Barbosa, Luiz Sergio, additional, D'Cruz, David, additional, Furie, Richard, additional, Maksimowicz‐McKinnon, Kathleen, additional, Oates, James, additional, Santiago, Mittermayer Barreto, additional, Saxena, Amit, additional, Sheikh, Saira, additional, Bass, Damon L., additional, Burriss, Susan W., additional, Gilbride, Jennifer A., additional, Groark, James G., additional, Miller, Michelle, additional, Pierce, Amy, additional, Roth, David A., additional, and Ji, Beulah, additional

Published
2021
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13. Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study

Author

Renauer, Paul A., Saruhan-Direskeneli, Guher, Coit, Patrick, Adler, Adam, Aksu, Kenan, Keser, Gokhan, Alibaz-Oner, Fatma, Aydin, Sibel Z., Kamali, Sevil, Inanc, Murat, Carette, Simon, Cuthbertson, David, Hoffman, Gary S., Akar, Servet, Onen, Fatos, Akkoc, Nurullah, Khalidi, Nader A., Koening, Curry, Karadag, Omer, Kiraz, Sedat, Langford, Carol A., Maksimowicz-McKinnon, Kathleen, McAlear, Carol A., Ozbalkan, Zeynep, Ates, Askin, Karaaslan, Yasar, Duzgun, Nursen, Monach, Paul A., Ozer, Huseyin T. E., Erken, Eren, Ozturk, Mehmet A., Yazici, Ayten, Cefle, Ayse, Onat, Ahmet Mesut, Kisacik, Bunyamin, Pagnoux, Christian, Kasifoglu, Timucin, Seyahi, Emire, Fresko, Izzet, Seo, Philip, Sreih, Antoine G., Warrington, Kenneth J., Ytterberg, Steven R., Cobankara, Veli, Cunninghame-Graham, Deborah S., Vyse, Timothy J., Pamuk, Omer N., Tunc, Ercan S., Dalkilic, Ediz, Bicakcigil, Muge, Yentur, Sibel P., Wren, Jonathan D., Merkel, Peter A., Direskeneli, Haner, and Sawalha, Amr H.

Published
2015
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14. Contributors

Author

Alberts, Mark J., primary, Battinelli, Elisabeth M., additional, Beckman, Joshua A., additional, Belkin, Michael, additional, Blei, Francine, additional, Blume, Peter, additional, Brass, Eric P., additional, Brennan, Christina, additional, Carter-Monroe, Naima, additional, Chacko, Billy G., additional, Chadachan, Veerendra, additional, Chan, Stephen Y., additional, Cid, Maria C., additional, Coselli, Joseph S., additional, Creager, Mark A., additional, Criqui, Michael H., additional, Cronenwett, Jack L., additional, Dake, Michael D., additional, Danczyk, Rachel C., additional, Davis, Mark D.P., additional, Duran, Cihan, additional, Eagleton, Matthew J., additional, Eberhardt, Robert T., additional, Eikelboom, John W., additional, Fisher, Marc, additional, Freedman, Jane E., additional, Freischlag, Julie Ann, additional, Fulton, David R., additional, Garg, Nitin, additional, Gerhard-Herman, Marie, additional, Gloviczki, Peter, additional, Goldhaber, Samuel Z., additional, Goldstein, Larry B., additional, Gornik, Heather L., additional, Greif, Daniel M., additional, Griendling, Kathy K., additional, Habersberger, Jonathon, additional, Halperin, Jonathan L., additional, Hansen, Kimberley J., additional, Haqqani, Omar P., additional, Harrison, David G., additional, Harthun, Nancy, additional, Hiatt, William R., additional, Hilenski, Lula L., additional, Hoffman, Gary S., additional, Huh, Joseph, additional, Iafrati, Mark D., additional, Iyer, Sriram S., additional, Keegan, Kirk A., additional, Kwolek, Christopher J., additional, Landry, Gregory J., additional, Lau, Joe F., additional, LeMaire, Scott A., additional, Leopold, Jane A., additional, Libby, Peter, additional, Lichtman, Judith H., additional, Long, Chandler A., additional, Loscalzo, Joseph, additional, Luther, James M., additional, Machleder, Herbert I., additional, Madder, Ryan D., additional, Mahameed, Amjad Al, additional, Maksimowicz-McKinnon, Kathleen, additional, Maron, Bradley A., additional, McPhee, James T., additional, Menard, Matthew T., additional, Merkel, Peter A., additional, Moneta, Gregory L., additional, Moore, Wesley S., additional, Newburger, Jane W., additional, Newton, William B., additional, O'Gara, Patrick T., additional, Olin, Jeffrey W., additional, Önal, Mehmet Zülküf, additional, Pande, Reena L., additional, Penson, David F., additional, Perlstein, Todd S., additional, Piazza, Gregory, additional, Plummer, Mitchell M., additional, Raghow, Rajendra, additional, Rajagopalan, Sanjay, additional, Rathbun, Suman, additional, Rockson, Stanley G., additional, Rooke, Thom W., additional, Roubin, Gary, additional, Rybicki, Frank J., additional, Safian, Robert D., additional, Shepherd, Roger F.J., additional, Sobieszczyk, Piotr S., additional, Stone, David H., additional, Sumpio, Bauer E., additional, Tafur, Alfonso J., additional, Taylor, Allen J., additional, Textor, Stephen C., additional, Upchurch, Gilbert R., additional, Valentine, R. James, additional, Virmani, Renu, additional, Vitek, Jiri, additional, Walls, Michael C., additional, Watkins, Michael T., additional, Weitz, Jeffrey I., additional, White, Christopher J., additional, and Williams, Timothy K., additional

Published
2013
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17. Patterns of Arterial Disease in Takayasu Arteritis and Giant Cell Arteritis

Author

Gribbons, K. Bates, primary, Ponte, Cristina, additional, Carette, Simon, additional, Craven, Anthea, additional, Cuthbertson, David, additional, Hoffman, Gary S., additional, Khalidi, Nader A., additional, Koening, Curry L., additional, Langford, Carol A., additional, Maksimowicz-McKinnon, Kathleen, additional, McAlear, Carol A., additional, Monach, Paul A., additional, Moreland, Larry W., additional, Pagnoux, Christian, additional, Quinn, Kaitlin A., additional, Robson, Joanna C., additional, Seo, Philip, additional, Sreih, Antoine G., additional, Suppiah, Ravi, additional, Warrington, Kenneth J., additional, Ytterberg, Steven R., additional, Luqmani, Raashid, additional, Watts, Richard, additional, Merkel, Peter A., additional, and Grayson, Peter C., additional

Published
2020
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18. List of Contributors

Author

Ahearn, Joseph M., primary, Amengual, Olga, additional, Amoura, Zahir, additional, Aranow, Cynthia, additional, Atkinson, John P., additional, Atsumi, Tatsuya, additional, Avalos, Ingrid, additional, Balomenos, Dimitrios, additional, Banchereau, Jacques, additional, Bertsias, George, additional, Böhm, Markus, additional, Boumpas, Dimitrios T., additional, Branch, D. Ware, additional, Brunner, Hermine I., additional, Buyon, Jill P., additional, Casciola-Rosen, Livia, additional, Cervera, Ricard, additional, Chamilos, George, additional, Chan, Edward K.L., additional, Clancy, Robert M., additional, Clark, Christine A., additional, Costedoat-Chalumeau, Nathalie, additional, Couto, Maura, additional, Crispín, José C., additional, Crow, Mary K., additional, Day, Michael J., additional, Diamond, Betty, additional, Dotan, Iris, additional, du Bois, Roland M., additional, Du, Yong, additional, Duarte, Catia, additional, Deng, Yun, additional, Dutz, Jan P., additional, Dvorkina, Olga, additional, Ernandez, Thomas, additional, Espinosa, Gerard, additional, Farris, A. Darise, additional, M.A. Fernando, Michelle, additional, Fessler, Barri J., additional, Fischer, Aryeh, additional, Friedman, Deborah M., additional, Fritzler, Marvin J., additional, Furie, Richard, additional, Gilkeson, Gary S., additional, Ginzler, Ellen M., additional, Hanly, John G., additional, Hess, Evelyn V., additional, Hoffman, Gary S., additional, Horowitz, Diane, additional, Ines, Luis, additional, Ioannou, Yiannis, additional, James, Judith A., additional, Jefferies, Caroline A., additional, Kalunian, Kenneth C., additional, Kaplan, Mariana J., additional, Kearns, Grainne, additional, Keogan, Mary, additional, Kellet, Cristián Vera, additional, Khamashta, Munther A., additional, Koike, Takao, additional, Kono, Dwight H., additional, Krilis, Steven A., additional, Kuhn, Annegret, additional, Kyttaris, Vasileios C., additional, Lahita, Robert G., additional, Laskin, Carl A., additional, Leroux, Gaëlle, additional, Li, Yi, additional, Liang, Matthew H., additional, Liu, Chau-Ching, additional, Luger, Thomas, additional, Mackay, Ian R., additional, Mackay, Meggan, additional, Maksimowicz-McKinnon, Kathleen, additional, Mamula, Mark J., additional, Manzi, Susan, additional, Marder, Galina, additional, Mashmoushi, Ahmad K., additional, Mayadas, T.N., additional, Mayer, Lloyd, additional, Means, Terry K., additional, Merrill, Joan T., additional, Milan, Kristina E., additional, Mina, Rina, additional, Mohan, Chandra, additional, Mongey, Anne-Barbara, additional, Monrad, Seetha U., additional, Nossent, Johannes C., additional, Oates, Jim C., additional, Obermoser, Gerlinde, additional, Palucka, Karolina, additional, Papadimitraki, Eva D., additional, Pascual, Virginia, additional, Perl, Andras, additional, Piette, Jean-Charles, additional, Pillai, Shiv, additional, Reeves, Westley H., additional, Richardson, Bruce C., additional, Rosen, Anthony, additional, Rovin, Brad H., additional, Satoh, Minoru, additional, Schur, Peter, additional, Spitzer, Karen A., additional, Stein, C. Michael, additional, Stillman, Isaac E., additional, Swaak, Tom J.G., additional, Taylor, Kendra N., additional, Theofilopoulos, Argyrios N., additional, Tsao, Betty P., additional, Tsokos, George, additional, Ueno, Hideki, additional, Uluğ, Aziz M., additional, Vista, Evan S., additional, Volpe, Bruce T., additional, Vyse, Tim J., additional, Wener, Mark H., additional, Werth, Victoria P., additional, Xu, Yuan, additional, Yang, Lijun, additional, Yu, C. Yung, additional, Yung, Raymond L., additional, Zhou, Dun, additional, and Zhuang, Haoyang, additional

Published
2011
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19. Heart

Author

Maksimowicz-McKinnon, Kathleen, primary and Manzi, Susan, additional

Published
2011
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21. Takayasu's Arteritis

Author

Hernández-Rodríguez, José, primary, Maksimowicz-McKinnon, Kathleen, additional, and Hoffman, Gary S., additional

Published
2010
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22. Phase III/IV, Randomized, Fifty‐Two–Week Study of the Efficacy and Safety of Belimumab in Patients of Black African Ancestry With Systemic Lupus Erythematosus.

Author

Ginzler, Ellen, Guedes Barbosa, Luiz Sergio, D'Cruz, David, Furie, Richard, Maksimowicz‐McKinnon, Kathleen, Oates, James, Santiago, Mittermayer Barreto, Saxena, Amit, Sheikh, Saira, Bass, Damon L., Burriss, Susan W., Gilbride, Jennifer A., Groark, James G., Miller, Michelle, Pierce, Amy, Roth, David A., and Ji, Beulah

Subjects
DRUG efficacy, RESEARCH, CONFIDENCE intervals, BLACK people, MEDICAL cooperation, RANDOMIZED controlled trials, QUESTIONNAIRES, DESCRIPTIVE statistics, SYSTEMIC lupus erythematosus, STATISTICAL sampling, ODDS ratio, BELIMUMAB, PATIENT safety
Abstract

Objective: Enrollment of patients of Black African ancestry with systemic lupus erythematosus (SLE) in phase II and phase III of the belimumab trials was not reflective of the racial distribution observed in the lupus population. This study was undertaken to assess the efficacy and safety of intravenous (IV) belimumab plus standard therapy in patients of self‐identified Black race. Methods: EMBRACE (GSK Study BEL115471; ClinicalTrials.gov identifier: NCT01632241) was a 52‐week multicenter, double‐blind, placebo‐controlled trial in adults of self‐identified Black race with active SLE who received monthly belimumab 10 mg/kg IV, or placebo, plus standard therapy. The optional 26‐week open‐label extension phase included patients who completed the double‐blind phase. The primary end point of the study was SLE Responder Index (SRI) response rate at week 52 with modified proteinuria scoring adapted from the SLE Disease Activity Index 2000 (SLEDAI‐2K) (SRI–SLEDAI‐2K). Key secondary end points included SRI response rate at week 52, time to first severe SLE flare, and reductions in prednisone dose. Results: The modified intent‐to‐treat population comprised 448 patients, of whom 96.9% were women and the mean ± SD age was 38.8 ± 11.42 years. The primary end point (improvement in the SRI–SLEDAI‐2K response rate at week 52) was not achieved (belimumab 48.7%, placebo 41.6%; odds ratio 1.40 [95% confidence interval 0.93, 2.11], P = 0.1068); however, numerical improvements favoring belimumab were observed, in which the SRI–SLEDAI‐2K response rates were higher in those who received belimumab compared with those who received placebo, especially in patients with SLE who had high disease activity or renal manifestations at baseline. The safety profile of belimumab was generally consistent with that observed in previous SLE trials. Adverse events were the primary reasons for double‐blind phase withdrawals (belimumab 5.4%, placebo 6.7%). Conclusion: The primary end point of this study was not achieved, but improvement with belimumab versus placebo was observed, suggesting that belimumab remains a suitable treatment option for SLE management in patients of Black African ancestry. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Derivation of an angiographically based classification system in Takayasu’s arteritis: an observational study from India and North America

Author

Goel, Ruchika, primary, Gribbons, K Bates, additional, Carette, Simon, additional, Cuthbertson, David, additional, Hoffman, Gary S, additional, Joseph, George, additional, Khalidi, Nader A, additional, Koening, Curry L, additional, Kumar, Sathish, additional, Langford, Carol, additional, Maksimowicz-McKinnon, Kathleen, additional, McAlear, Carol A, additional, Monach, Paul A, additional, Moreland, Larry W, additional, Nair, Aswin, additional, Pagnoux, Christian, additional, Quinn, Kaitlin A, additional, Ravindran, Raheesh, additional, Seo, Philip, additional, Sreih, Antoine G, additional, Warrington, Kenneth J, additional, Ytterberg, Steven R, additional, Merkel, Peter A, additional, Danda, Debashish, additional, and Grayson, Peter C, additional

Published
2019
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26. CONTRIBUTORS

Author

AlMahameed, Amjad, primary, Ansell, Jack E., additional, Aquino, Melinda, additional, Aruny, John, additional, Ayerdi, Juan, additional, Beckman, Joshua A., additional, Belch, Jill J.F., additional, Belkin, Michael, additional, Berk, Bradford C., additional, Blei, Francine, additional, Blume, Peter, additional, Brass, Eric P., additional, Burke, Allen P., additional, Caplan, Louis R., additional, Cid, Maria C., additional, Coffman, Jay D., additional, Cooke, John P., additional, Creager, Mark A., additional, Criqui, Michael H., additional, Cronenwett, Jack L., additional, Davis, Mark D.P., additional, del Zoppo, Gregory J., additional, Donaldson, Magruder C., additional, Eagleton, Matthew J., additional, Edwards, Matthew S., additional, Fisher, Jonathan E.E., additional, Flohr, Thomas G., additional, Freedman, Jane E., additional, Freischlag, Julie A., additional, Fulton, David R., additional, Gerhard-Herman, Marie, additional, Giswold, Mary E., additional, Goldhaber, Samuel Z., additional, Goldstein, Irwin, additional, Gornik, Heather L., additional, Gram, Christopher H., additional, Gravereaux, Edwin C., additional, Halperin, Jonathan L., additional, Hansen, Kimberley J., additional, Hanzel, George, additional, Hiatt, William R., additional, Hobson, Robert W., additional, Hoffman, Gary S., additional, Iyer, Sriram S., additional, Kane, Laura B., additional, Kang, Andrew, additional, Kannel, William B., additional, Karamlou, Tara, additional, Kim, Noel N., additional, Klings, Elizabeth S., additional, Kronzon, Itzhak, additional, Kucher, Nils, additional, Lam, Everett Y., additional, Landry, Gregory J., additional, LeMaire, Scott A., additional, Lerman, Lilach O., additional, Libby, Peter, additional, Lipton, Martin J., additional, Loscalzo, Joseph, additional, Machleder, Herbert I., additional, Maksimowicz-McKinnon, Kathleen, additional, Mandel, Jess, additional, Menard, Matthew T., additional, Menzoian, James O., additional, Merkel, Peter A., additional, Miller, Virginia M., additional, Moneta, Gregory L., additional, Munarriz, Ricardo, additional, Newburger, Jane W., additional, Ninomiya, John, additional, O'Gara, Patrick, additional, Olin, Jeffrey W., additional, O'Rourke, Stephen T., additional, Ouriel, Kenneth, additional, Paszkowiak, Jacek, additional, Patterson, Dean, additional, Raffetto, Joseph D., additional, Raghow, Rajendra, additional, Rigberg, David A., additional, Rockson, Stanley G., additional, Rooke, Thom W., additional, Roubin, Gary S., additional, Ruberg, Frederick L., additional, Rzucidlo, Eva M., additional, Safian, Robert D., additional, Schoepf, U. Joseph, additional, Seyer, Jerome, additional, Sobieszczyk, Piotr, additional, Srivastava, Sunita D., additional, Stanton-Hicks, Michael, additional, Sumpio, Bauer E., additional, Taylor, Allen J., additional, Taylor, Lloyd M., additional, Textor, Stephen C., additional, Thompson, Robert W., additional, Topper, James N., additional, Traish, Abdul M., additional, Tunick, Paul A., additional, Upchurch, Gilbert R., additional, Valentine, R. James, additional, Vanhoutte, Paul M., additional, Virmani, Renu, additional, Vitek, Jiri J., additional, Wasserman, Scott M., additional, Weisz, Giora, additional, Welborn, M. Burress, additional, White, Christopher J., additional, Wilson, David B., additional, Wolf, Philip A., additional, and Yucel, E. Kent, additional

Published
2006
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31. Takayasu arteritis and giant cell arteritis: a spectrum within the same disease?

Author

Maksimowicz-McKinnon, Kathleen, Clark, Tiffany M., and Hoffman, Gary S.

Subjects
Giant cell arteritis -- Development and progression, Giant cell arteritis -- Diagnosis, Giant cell arteritis -- Research, Takayasu's arteritis -- Development and progression, Takayasu's arteritis -- Diagnosis, Takayasu's arteritis -- Research
Published
2009

32. Efficacy and Safety of Belimumab and Azathioprine for Maintenance of Remission in ANCA-Associated Vasculitis: A Randomized Controlled Study

Author

Jayne, David, Blockmans, Daniel, Luqmani, Raashid, Moiseev, Sergey, Beulah, Ji, Green, Yulia, Hall, Leanne, Roth, David, Henderson, Robert B, Merkel, Peter A, Lozano, Jose Alfaro, Becker, Heidemarie, Quiroz, Armando Calvo, Carette, Simon, Carrillo-Vazquez, Sandra, Cid, María C, D'Cruz, David, Deodhar, Atul, Flossman, Oliver, Garibotto, Giacomo, Gesualdo, Loreto, Hall, Stephen, Hauser, Thomas, Hellmich, Bernhard, Kidder, Dana, Kimmel, Martin, Little, Mark, Majdan, Maria, Maksimowicz-McKinnon, Kathleen, Marder, Galina, Matsievskaia, Galina, Meneses, Ariel Salinas, Molloy, Eamonn, Mueller, Ruediger, Neuwelt, Clark, Hernandez, Jorge Ravelo, Specks, Ulrich, Tesar, Vladimir, and Walsh, Michael

Subjects
Vasculitis, Randomized Trial, ANCA-Associated Vasculitis, B-Lymphocyte, Randomized Trial, Vasculitis, B-Lymphocyte, ANCA-Associated Vasculitis
Published
2019

36. 084. DISCOVERY AND VALIDATION OF A NOVEL ANGIOGRAPHIC CLASSIFICATION SCHEME IN TAKAYASU’S ARTERITIS

Author

Gribbons, Katherine, primary, Goel, Ruchika, additional, Cuthbertson, David, additional, Carette, Simon, additional, Hoffman, Gary S, additional, Joseph, George, additional, Khalidi, Nader A, additional, Koening, Curry L, additional, Langford, Carol, additional, Maksimowicz-McKinnon, Kathleen, additional, McAlear, Carol A, additional, Monach, Paul A, additional, Moreland, Larry W, additional, Nair, Aswin, additional, Pagnoux, Christian, additional, Ravindran, Raheesh, additional, Seo, Philip, additional, Sreih, Antoine G, additional, Warrington, Kenneth J, additional, Ytterberg, Steven R, additional, Merkel, Peter A, additional, Danda, Debashish, additional, and Grayson, Peter C, additional

Published
2019
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37. 083. COMPARISON OF ARTERIAL PATTERNS OF DISEASE IN TAKAYASU’S ARTERITIS AND GIANT CELL ARTERITIS

Author

Gribbons, Katherine, primary, Ponte, Cristina, additional, Craven, Anthea, additional, Cuthbertson, David, additional, Carette, Simon, additional, Hoffman, Gary, additional, Khalidi, Nader, additional, Koening, Curry, additional, Langford, Carol, additional, Maksimowicz-McKinnon, Kathleen, additional, McAlear, Carol, additional, Monach, Paul, additional, Moreland, Larry, additional, Pagnoux, Christian, additional, Quinn, Kaitlin, additional, Robson, Joanna, additional, Seo, Philip, additional, Sreih, Antoine, additional, Suppiah, Ravi, additional, Warrington, Kenneth, additional, Ytterberg, Steven, additional, Luqmani, Raashid, additional, Watts, Richard, additional, Merkel, Peter, additional, and Grayson, Peter, additional

Published
2019
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38. Role of Macrophage Migration Inhibitory Factor in Granulomatosis With Polyangiitis

Author

Sreih, Antoine G., primary, Ezzedine, Rana, additional, Leng, Lin, additional, Fan, Juan, additional, Yao, Jie, additional, Reid, Duncan, additional, Piecychna, Marta, additional, Carette, Simon, additional, Cuthbertson, David, additional, Dellaripa, Paul, additional, Hoffman, Gary S., additional, Khalidi, Nader A., additional, Koening, Curry L., additional, Langford, Carol A., additional, Mahr, Alfred, additional, McAlear, Carol A., additional, Maksimowicz‐Mckinnon, Kathleen, additional, Monach, Paul A., additional, Seo, Philip, additional, Specks, Ulrich, additional, St.Clair, E. William, additional, Stone, John H., additional, Ytterberg, Steven R., additional, Edberg, Jeffrey, additional, Merkel, Peter A., additional, and Bucala, Richard, additional

Published
2018
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39. Derivation of an angiographically based classification system in Takayasu's arteritis: an observational study from India and North America.

Author

Goel, Ruchika, Gribbons, K Bates, Carette, Simon, Cuthbertson, David, Hoffman, Gary S, Joseph, George, Khalidi, Nader A, Koening, Curry L, Kumar, Sathish, Langford, Carol, Maksimowicz-McKinnon, Kathleen, McAlear, Carol A, Monach, Paul A, Moreland, Larry W, Nair, Aswin, Pagnoux, Christian, Quinn, Kaitlin A, Ravindran, Raheesh, Seo, Philip, and Sreih, Antoine G

Subjects
AORTA radiography, ABDOMINAL aorta, ACADEMIC medical centers, ANGIOGRAPHY, ARTERIES, CAROTID artery, CLUSTER analysis (Statistics), COMPUTED tomography, MAGNETIC resonance imaging, MESENTERIC artery, SCIENTIFIC observation, RENAL artery, SUBCLAVIAN artery, VASCULITIS, TAKAYASU arteritis
Abstract

Objectives To develop and replicate, using data-driven methods, a novel classification system in Takayasu's arteritis based on distribution of arterial lesions. Methods Patients were included from four international cohorts at major academic centres: India (Christian Medical College Vellore); North America (National Institutes of Health, Vasculitis Clinical Research Consortium and Cleveland Clinic Foundation). All patients underwent whole-body angiography of the aorta and branch vessels, with categorization of arterial damage (stenosis, occlusion or aneurysm) in 13 territories. K-means cluster analysis was performed to identify subgroups of patients based on pattern of angiographic involvement. Cluster groups were identified in the Indian cohort and independently replicated in the North American cohorts. Results A total of 806 patients with Takayasu's arteritis from India (n = 581) and North America (n = 225) were included. Three distinct clusters defined by arterial damage were identified in the Indian cohort and replicated in each of the North American cohorts. Patients in cluster one had significantly more disease in the abdominal aorta, renal and mesenteric arteries (P < 0.01). Patients in cluster two had significantly more bilateral disease in the carotid and subclavian arteries (P < 0.01). Compared with clusters one and two, patients in cluster three had asymmetric disease with fewer involved territories (P < 0.01). Demographics, clinical symptoms and clinical outcomes differed by cluster. Conclusion This large study in Takayasu's arteritis identified and replicated three novel subsets of patients based on patterns of arterial damage. Angiographic-based disease classification requires validation by demonstrating potential aetiological or prognostic implications. [ABSTRACT FROM AUTHOR]

Published
2020
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40. Brief Report: Whole‐Exome Sequencing to Identify Rare Variants and Gene Networks That Increase Susceptibility to Scleroderma in African Americans

Author

Gourh, Pravitt, primary, Remmers, Elaine F., additional, Boyden, Steven E., additional, Alexander, Theresa, additional, Morgan, Nadia D., additional, Shah, Ami A., additional, Mayes, Maureen D., additional, Doumatey, Ayo, additional, Bentley, Amy R., additional, Shriner, Daniel, additional, Domsic, Robyn T., additional, Medsger, Thomas A., additional, Steen, Virginia D., additional, Ramos, Paula S., additional, Silver, Richard M., additional, Korman, Benjamin, additional, Varga, John, additional, Schiopu, Elena, additional, Khanna, Dinesh, additional, Hsu, Vivien, additional, Gordon, Jessica K., additional, Saketkoo, Lesley Ann, additional, Gladue, Heather, additional, Kron, Brynn, additional, Criswell, Lindsey A., additional, Derk, Chris T., additional, Bridges, S. Louis, additional, Shanmugam, Victoria K., additional, Kolstad, Kathleen D., additional, Chung, Lorinda, additional, Jan, Reem, additional, Bernstein, Elana J., additional, Goldberg, Avram, additional, Trojanowski, Marcin, additional, Kafaja, Suzanne, additional, Maksimowicz‐McKinnon, Kathleen M., additional, Mullikin, James C., additional, Adeyemo, Adebowale, additional, Rotimi, Charles, additional, Boin, Francesco, additional, Kastner, Daniel L., additional, and Wigley, Fredrick M., additional

Published
2018
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41. CD4+CD28+KIR+CD11ahi T cells correlate with disease activity and are characterized by a pro-inflammatory epigenetic and transcriptional profile in lupus patients

Author

Gensterblum, Elizabeth, primary, Renauer, Paul, additional, Coit, Patrick, additional, Strickland, Faith M., additional, Kilian, Nathan C., additional, Miller, Shaylynn, additional, Ognenovski, Mikhail, additional, Wren, Jonathan D., additional, Tsou, Pei-Suen, additional, Lewis, Emily E., additional, Maksimowicz-McKinnon, Kathleen, additional, McCune, W. Joseph, additional, Richardson, Bruce C., additional, and Sawalha, Amr H., additional

Published
2018
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43. A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis

Author

Carmona, F. David, primary, Vaglio, Augusto, additional, Mackie, Sarah L., additional, Hernández-Rodríguez, José, additional, Monach, Paul A., additional, Castañeda, Santos, additional, Solans, Roser, additional, Morado, Inmaculada C., additional, Narváez, Javier, additional, Ramentol-Sintas, Marc, additional, Pease, Colin T., additional, Dasgupta, Bhaskar, additional, Watts, Richard, additional, Khalidi, Nader, additional, Langford, Carol A., additional, Ytterberg, Steven, additional, Boiardi, Luigi, additional, Beretta, Lorenzo, additional, Govoni, Marcello, additional, Emmi, Giacomo, additional, Bonatti, Francesco, additional, Cimmino, Marco A., additional, Witte, Torsten, additional, Neumann, Thomas, additional, Holle, Julia, additional, Schönau, Verena, additional, Sailler, Laurent, additional, Papo, Thomas, additional, Haroche, Julien, additional, Mahr, Alfred, additional, Mouthon, Luc, additional, Molberg, Øyvind, additional, Diamantopoulos, Andreas P., additional, Voskuyl, Alexandre, additional, Brouwer, Elisabeth, additional, Daikeler, Thomas, additional, Berger, Christoph T., additional, Molloy, Eamonn S., additional, O’Neill, Lorraine, additional, Blockmans, Daniel, additional, Lie, Benedicte A., additional, Mclaren, Paul, additional, Vyse, Timothy J., additional, Wijmenga, Cisca, additional, Allanore, Yannick, additional, Koeleman, Bobby P.C., additional, Barrett, Jennifer H., additional, Cid, María C., additional, Salvarani, Carlo, additional, Merkel, Peter A., additional, Morgan, Ann W., additional, González-Gay, Miguel A., additional, Martín, Javier, additional, Callejas, José Luis, additional, Caminal-Montero, Luis, additional, Corbera-Bellalta, Marc, additional, de Miguel, Eugenio, additional, López, J. Bernardino Díaz, additional, García-Villanueva, María Jesús, additional, Gómez-Vaquero, Carmen, additional, Guijarro-Rojas, Mercedes, additional, Hidalgo-Conde, Ana, additional, Marí-Alfonso, Begoña, additional, Berriochoa, Agustín Martínez, additional, Zapico, Aleida Martínez, additional, Martínez-Taboada, Víctor Manuel, additional, Miranda-Filloy, José A., additional, Monfort, Jordi, additional, Ortego-Centeno, Norberto, additional, Pérez-Conesa, Mercedes, additional, Prieto-González, Sergio, additional, Raya, Enrique, additional, Fernández, Raquel Ríos, additional, Sánchez-Martín, Julio, additional, Sopeña, Bernardo, additional, Tío, Laura, additional, Unzurrunzaga, Ainhoa, additional, Gough, Andrew, additional, Isaacs, John D., additional, Green, Michael, additional, McHugh, Neil, additional, Hordon, Lesley, additional, Kamath, Sanjeet, additional, Nisar, Mohammed, additional, Patel, Yusuf, additional, Yee, Cee-Seng, additional, Stevens, Robert, additional, Nandi, Pradip, additional, Nandagudi, Anupama, additional, Jarrett, Stephen, additional, Li, Charles, additional, Levy, Sarah, additional, Mollan, Susan, additional, Salih, Abdel, additional, Wordsworth, Oliver, additional, Sanders, Emma, additional, Roads, Esme, additional, Gill, Anne, additional, Carr, Lisa, additional, Routledge, Christine, additional, Culfear, Karen, additional, Nugaliyadde, Asanka, additional, James, Lynne, additional, Spimpolo, Jenny, additional, Kempa, Andy, additional, Mackenzie, Felicity, additional, Fong, Rosanna, additional, Peters, Genessa, additional, Rowbotham, Bridie, additional, Masqood, Zahira, additional, Hollywood, Jane, additional, Gondo, Prisca, additional, Wood, Rose, additional, Martin, Steve, additional, Rashid, Lubna Haroon, additional, Robinson, James I., additional, Morgan, Mike, additional, Sorensen, Louise, additional, Taylor, John, additional, Carette, Simon, additional, Chung, Sharon, additional, Cuthbertson, David, additional, Forbess, Lindsy J., additional, Gewurz-Singer, Ora, additional, Hoffman, Gary S., additional, Koening, Curry L., additional, Maksimowicz-McKinnon, Kathleen M., additional, McAlear, Carol A., additional, Moreland, Larry W., additional, Pagnoux, Christian, additional, Seo, Philip, additional, Specks, Ulrich, additional, Spiera, Robert F., additional, Sreih, Antoine, additional, Warrington, Kenneth J., additional, and Weisman, Michael, additional

Published
2017
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44. Genome-wide association study identifies susceptibility loci in IL6, RPS9/LILRB3, and an intergenic locus on chromosome 21q22 in Takayasu’s arteritis

Author

Renauer, Paul, Saruhan-Direskeneli, Guher, Coit, Patrick, Adler, Adam, Aksu, Kenan, Keser, Gokhan, Alibaz-Oner, Fatma, Aydin, Sibel Z., Kamali, Sevil, Inanc, Murat, Carette, Simon, Cuthbertson, David, Hoffman, Gary S., Akar, Servet, Onen, Fatos, Akkoc, Nurullah, Khalidi, Nader A., Koening, Curry, Karadag, Omer, Kiraz, Sedat, Langford, Carol A., Maksimowicz-McKinnon, Kathleen, McAlear, Carol A., Ozbalkan, Zeynep, Ates, Askin, Karaaslan, Yasar, Duzgun, Nursen, Monach, Paul A., Ozer, Huseyin TE, Erken, Eren, Ozturk, Mehmet A., Yazici, Ayten, Cefle, Ayse, Onat, A. Mesut, Kisacik, Bunyamin, Pagnoux, Christian, Kasifoglu, Timucin, Seyahi, Emire, Fresko, Izzet, Seo, Philip, Sreih, Antoine, Warrington, Kenneth J., Ytterberg, Steven R., Cobankara, Veli, Cunninghame-Graham, Deborah S., Vyse, Timothy J., Pamuk, Omer N., Tunc, Ercan, Dalkilic, Ediz, Bicakcigil, Muge, Yentur, Sibel P., Wren, Jonathan D., Merkel, Peter A., Direskeneli, Haner, and Sawalha, Amr H.

Subjects
Ribosomal Proteins, Turkey, Chromosomes, Human, Pair 21, Interleukin-6, Ribosomal Protein S9, Takayasu Arteritis, Article, White People, Cohort Studies, Antigens, CD, Case-Control Studies, North America, Odds Ratio, Humans, Genetic Predisposition to Disease, Receptors, Immunologic, Genome-Wide Association Study
Abstract

Takayasu arteritis is a rare large vessel vasculitis with incompletely understood etiology. This study was undertaken to perform the first unbiased genome-wide association analysis of Takayasu arteritis.Two independent cohorts of patients with Takayasu arteritis from Turkey and North America were included in our study. The Turkish cohort consisted of 559 patients and 489 controls, and the North American cohort consisted of 134 patients and 1,047 controls of European ancestry. Genotyping was performed using the Omni1-Quad and Omni2.5 genotyping arrays. Genotyping data were subjected to rigorous quality control measures and subsequently analyzed to discover genetic susceptibility loci for Takayasu arteritis.We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)). The genetic susceptibility locus in RPS9/LILRB3 lies within the leukocyte receptor complex gene cluster on chromosome 19q13.4, and the disease risk variant in this locus correlates with reduced expression of multiple genes including the inhibitory leukocyte immunoglobulin-like receptor gene LILRB3 (P = 2.29 × 10(-8)). In addition, we identified candidate susceptibility genes with suggestive levels of association (P1 × 10(-5)) with Takayasu arteritis, including PCSK5, LILRA3, PPM1G/NRBP1, and PTK2B.Our findings indicate novel genetic susceptibility loci for Takayasu arteritis and uncover potentially important aspects of the pathophysiology of this form of vasculitis.

Published
2015

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