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297 results on '"Makristathis, Athanasios"'

2. Clinical characteristics of a large cohort of patients with positive culture of Fusobacterium necrophorum

Author

Klasinc, Romana, Lupyr, Kostiantyn, Zeller, Iris, Paula, Helga, Makristathis, Athanasios, Tuchmann, Felix, Wrba, Thomas, Assadian, Ojan, and Presterl, Elisabeth

Subjects
Fusobacterium necrophorum, Lemierre’s disease, anaerobe, sepsis, thrombosis, Infectious and parasitic diseases, RC109-216
Abstract

Background: is a rare pathogen, mostly affecting young adults, causing infections of the head and neck, typically described as the Lemierre’s syndrome. Today this symptom complex has become increasingly rare and has almost turned to a ‘forgotten disease’. Methods: We performed a retrospective, descriptive study to identify the clinical features of patients with positive culture of . Additionally, the antibiotic susceptibility profile of the pathogens was analysed.Results: During a period of 22 years 36 patients with at least one isolate of were identified. Mostly tonsillar and peritonsillar abscesses were found, 10 patients were identified with bacteraemia, but only 4 patients presented with symptoms like sore throat, fever and swollen cervical lymph nodes, which may suggest Lemierre’s. Most of the isolates (33/35) showed sensitivity to all tested antibiotics.Conclusion: Appropriate techniques are needed to detect , especially from throat swabs, in the microbiological laboratory. Current clinical and microbiological practice may lead to under-diagnosis of infections caused by . Further research is needed to define the colonization rate and to optimize methods for detection as well as identification of virulence.

Published
2018
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4. Disturbances in microbial skin recolonization and cutaneous immune response following allogeneic stem cell transfer

Author

Bayer, Nadine, Hausman, Bela, Pandey, Ram Vinay, Deckert, Florian, Gail, Laura-Marie, Strobl, Johanna, Pjevac, Petra, Krall, Christoph, Unterluggauer, Luisa, Redl, Anna, Bachmayr, Victoria, Kleissl, Lisa, Nehr, Marion, Kirkegaard, Rasmus, Makristathis, Athanasios, Watzenboeck, Martin L., Nica, Robert, Staud, Clement, Hammerl, Lukas, Wohlfarth, Philipp, Ecker, Rupert C., Knapp, Sylvia, Rabitsch, Werner, Berry, David, and Stary, Georg

Published
2022
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6. Correction: Disturbances in microbial skin recolonization and cutaneous immune response following allogeneic stem cell transfer

Author

Bayer, Nadine, Hausmann, Bela, Pandey, Ram Vinay, Deckert, Florian, Gail, Laura-Marie, Strobl, Johanna, Pjevac, Petra, Krall, Christoph, Unterluggauer, Luisa, Redl, Anna, Bachmayr, Victoria, Kleissl, Lisa, Nehr, Marion, Kirkegaard, Rasmus, Makristathis, Athanasios, Watzenboeck, Martin L., Nica, Robert, Staud, Clement, Hammerl, Lukas, Wohlfarth, Philipp, Ecker, Rupert C., Knapp, Sylvia, Rabitsch, Werner, Berry, David, and Stary, Georg

Published
2023
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9. Effect of Antibiotic Eye Drops on the Nasal Microbiome in Healthy Subjects—A Pilot Study

Author

Nadvornik, Clemens, primary, Kallab, Martin, additional, Hommer, Nikolaus, additional, Schlatter, Andreas, additional, Stengel, Theresa, additional, Garhöfer, Gerhard, additional, Zeitlinger, Markus, additional, Eberl, Sabine, additional, Klymiuk, Ingeborg, additional, Trajanoski, Slave, additional, Nehr, Marion, additional, Makristathis, Athanasios, additional, Schmidl, Doreen, additional, and Nussbaumer-Proell, Alina, additional

Published
2023
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10. Candida auris in Austria—What Is New and What Is Different

Author

Spettel, Kathrin, primary, Kriz, Richard, additional, Wu, Christine, additional, Achter, Lukas, additional, Schmid, Stefan, additional, Galazka, Sonia, additional, Selitsch, Brigitte, additional, Camp, Iris, additional, Makristathis, Athanasios, additional, Lagler, Heimo, additional, and Willinger, Birgit, additional

Published
2023
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14. Atypical enteropathogenic E. coli are associated with disease activity in ulcerative colitis

Author

Baumgartner, Maximilian, primary, Zirnbauer, Rebecca, additional, Schlager, Sabine, additional, Mertens, Daniel, additional, Gasche, Nikolaus, additional, Sladek, Barbara, additional, Herbold, Craig, additional, Bochkareva, Olga, additional, Emelianenko, Vera, additional, Vogelsang, Harald, additional, Lang, Michaela, additional, Klotz, Anton, additional, Moik, Birgit, additional, Makristathis, Athanasios, additional, Berry, David, additional, Dabsch, Stefanie, additional, Khare, Vineeta, additional, and Gasche, Christoph, additional

Published
2022
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20. A multicenter prospective study on the diagnostic performance of a new liquid rapid urease test for the diagnosis of Helicobacter pylori infection

Author

Dolak, Werner, Bilgilier, Ceren, Stadlmann, Alexander, Leiner, Judith, Püspök, Andreas, Plieschnegger, Wolfgang, Siebert, Franz, Wewalka, Friedrich, Schöfl, Rainer, Huber-Schönauer, Ursula, Datz, Christian, Biowski-Frotz, Susanne, Högenauer, Christoph, Schrutka-Kölbl, Christiane, Makristathis, Athanasios, Schöniger-Hekele, Maximilian, and Steininger, Christoph

Published
2017
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21. 406: RUMINOCOCCUS GNAVUS 3β-HSDH LINKS MUCOSAL BIOFILMS AND BILE ACID MALABSORPTION

Author

Baumgartner, Maximilian, primary, Lang, Michaela, additional, Nehr, Marion, additional, Pjevac, Petra, additional, Hausmann, Bela, additional, Kirkegaard, Rasmus H., additional, Klotz, Anton, additional, Khare, Vineeta, additional, Berry, David, additional, Muttenthaler, Markus, additional, Makristathis, Athanasios, additional, and Gasche, Christoph, additional

Published
2022
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23. Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis

Author

Baumgartner, Maximilian, primary, Lang, Michaela, additional, Holley, Hunter, additional, Crepaz, Daniel, additional, Hausmann, Bela, additional, Pjevac, Petra, additional, Moser, Doris, additional, Haller, Felix, additional, Hof, Fabian, additional, Beer, Andrea, additional, Orgler, Elisabeth, additional, Frick, Adrian, additional, Khare, Vineeta, additional, Evstatiev, Rayko, additional, Strohmaier, Susanne, additional, Primas, Christian, additional, Dolak, Werner, additional, Köcher, Thomas, additional, Klavins, Kristaps, additional, Rath, Timo, additional, Neurath, Markus F., additional, Berry, David, additional, Makristathis, Athanasios, additional, Muttenthaler, Markus, additional, and Gasche, Christoph, additional

Published
2021
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30. Detection and prediction of active tuberculosis disease by a whole-blood interferon-(gamma) release assay in HIV-1-infected individuals

Author

Aichelburg, Maximilian C., Rieger, Armin, Breitenecker, Florian, Pfistershammer, Katharina, Tittes, Julia, Eltz, Stephanie, Aichelburg, Alexander C., Stingl, Georg, Makristathis, Athanasios, and Kohrgruber, Norbert

Subjects
Tuberculosis -- Diagnosis, Tuberculosis -- Demographic aspects, Tuberculosis -- Research, HIV patients -- Medical examination, Immunoassay -- Usage, Interferon gamma -- Physiological aspects, Interferon gamma -- Analysis, Health, Health care industry
Published
2009

31. Lessons from low seroprevalence of SARS‐CoV‐2 antibodies in schoolchildren: A cross‐sectional study

Author

Szépfalusi, Zsolt, primary, Schmidthaler, Klara, additional, Sieber, Justyna, additional, Kopanja, Sonja, additional, Götzinger, Florian, additional, Schoof, Anja, additional, Hoz, Jakub, additional, Willinger, Birgit, additional, Makristathis, Athanasios, additional, Weseslindtner, Lukas, additional, Stiasny, Karin, additional, Bohle, Barbara, additional, Krotka, Pavla, additional, Graf, Alexandra, additional, and Frischer, Thomas, additional

Published
2021
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37. Apparent Intracellular Helicobacter pylori Detected by Immunohistochemistry: The Missing Link in Eradication Failure.

Author

Beer, Andrea, Hudler, Helmut, Hader, Maria, Kundi, Michael, Hudler, Susanne, Täuber, Valentina, Schachner, Helga, Gruber, Sophie, Hirschl, Alexander M, Kain, Renate, and Makristathis, Athanasios

Subjects
HELICOBACTER pylori, BIOPSY, IMMUNOHISTOCHEMISTRY, CLARITHROMYCIN, TREATMENT failure, PROTON pump inhibitors, POLYMERASE chain reaction, DRUG resistance in microorganisms, HELICOBACTER diseases, AMOXICILLIN
Abstract

Background Helicobacter pylori is primarily an extracellularly living bacterium. However, seemingly intracellular occurrence can often be detected by immunohistochemical stains. Considering antimicrobial resistance, we investigated the impact of the apparent intracellular H. pylori (aiHp) on treatment failure of first-line triple therapies. Methods Gastric biopsies of 814 patients infected with H. pylori naive to treatment were analyzed before and after eradication therapy by immunohistochemistry. Of these, 373 received treatment consisting of amoxicillin, clarithromycin, and proton pump inhibitor (AC/PPI). Availability of polymerase chain reaction-based clarithromycin susceptibility test results from pretreatment gastric biopsies was a precondition for matching 52 aiHp to 52 non-aiHp cases within the AC/PPI group. Results AiHp were detected mostly in low counts predominantly in corpus biopsies, rarely in antrum biopsies (95.2% vs 24.6%); they were found in 497 (61%) of all patients and in 192 of 373 patients (51.5%) in the AC/PPI group. The eradication rate in aiHp versus non-aiHp cases was 44.4% versus 72.9% in the entire sample and 45.3% versus 66.8% in the AC/PPI group. Among the 104 paired patients, respective values were 46.2% versus 78.8%; in clarithromycin-susceptible cases, 60.6% versus 91.9%. Both aiHp and resistance to clarithromycin proved to be highly significant (P  ≤ .001) and independent predictors of eradication failure. Twelve of 13 aiHp cases with a clarithromycin-sensitive strain who failed eradication developed resistance to the antibiotic. Conclusions AiHp found by immunohistochemical staining especially in corpus biopsies proved to be a risk factor for failure of first-line triple therapies; occurrence of aiHp should be considered with regard to therapy options. [ABSTRACT FROM AUTHOR]

Published
2021
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41. Re: Comment on “Incidence of risk factors for bloodstream infections in patients with major burns receiving intensive care: A retrospective single-center cohort study”

Author

Fochtmann-Frana, Alexandra, primary, Freystätter, Christian, additional, Vorstandlechner, Vera, additional, Barth, André, additional, Bolliger, Michael, additional, Presterl, Elisabeth, additional, Ihra, Gerald, additional, Muschitz, Gabriela, additional, Mittlboeck, Martina, additional, Makristathis, Athanasios, additional, Rath, Thomas, additional, Radtke, Christine, additional, and Forstner, Christina, additional

Published
2019
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43. Anti-bacterial activity of intermittent preventive treatment of malaria in pregnancy: comparative in vitro study of sulphadoxine-pyrimethamine, mefloquine, and azithromycin

Author

Mombo-Ngoma Ghyslain, Capan Mesküre, Makristathis Athanasios, and Ramharter Michael

Subjects
Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Intermittent preventive treatment of malaria with sulphadoxine-pyrimethamine (SP) is recommended for the prevention of malaria in pregnancy in sub-Saharan Africa. Increasing drug resistance necessitates the urgent evaluation of alternative drugs. Currently, the most promising candidates in clinical development are mefloquine and azithromycin. Besides the anti-malarial activity, SP is also a potent antibiotic and incurs significant anti-microbial activity when given as IPTp - though systematic clinical evaluation of this action is still lacking. Methods In this study, the intrinsic anti-bacterial activity of mefloquine and azithromycin was assessed in comparison to sulphadoxine-pyrimethamine against bacterial pathogens with clinical importance in pregnancy in a standard microdilution assay. Results SP was highly active against Staphylococcus aureus and Streptococcus pneumoniae. All tested Gram-positive bacteria, except Enterococcus faecalis, were sensitive to azithromycin. Additionally, azithromycin was active against Neisseria gonorrhoeae. Mefloquine showed good activity against pneumococci but lower in vitro action against all other tested pathogens. Conclusion These data indicate important differences in the spectrum of anti-bacterial activity for the evaluated anti-malarial drugs. Given the large scale use of IPTp in Africa, the need for prospective clinical trials evaluating the impact of antibiotic activity of anti-malarials on maternal and foetal health and on the risk of promoting specific drug resistance of bacterial pathogens is discussed.

Published
2010
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44. Data correction pre-processing for electronically stored blood culture results: Implications on microbial spectrum and empiric antibiotic therapy

Author

Koller Walter, Blacky Alexander, Makristathis Athanasios, Diab-Elschahawi Magda, Assadian Ojan, and Adlassnig Klaus-Peter

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Abstract Background The outcome of patients with bacteraemia is influenced by the initial selection of adequate antimicrobial therapy. The objective of our study was to clarify the influence of different crude data correction methods on a) microbial spectrum and ranking of pathogens, and b) cumulative antimicrobial susceptibility pattern of blood culture isolates obtained from patients from intensive care units (ICUs) using a computer based tool, MONI. Methods Analysis of 13 ICUs over a period of 7 years yielded 1427 microorganisms from positive results. Three different data correction methods were applied. Raw data method (RDM): Data without further correction, including all positive blood culture results. Duplicate-free method (DFM): Correction of raw data for consecutive patient's results yielding same microorganism with similar antibiogram within a two-week period. Contaminant-free method (CFM): Bacteraemia caused by possible contaminants was only assumed as true bloodstream infection, if an organism of the same species was isolated from > 2 sets of blood cultures within 5 days. Results Our study demonstrates that different approaches towards raw data correction – none (RDM), duplicate-free (DFM), and a contaminant-free method (CFM) – show different results in analysis of positive blood cultures. Regarding the spectrum of microorganisms, RDM and DFM yielded almost similar results in ranking of microorganisms, whereas using the CFM resulted in a clinically and epidemiologically more plausible spectrum. Conclusion For possible skin contaminants, the proportion of microorganisms in terms of number of episodes is most influenced by the CFM, followed by the DFM. However, with exception of fusidic acid for gram-positive organisms, none of the evaluated correction methods would have changed advice for empiric therapy on the selected ICUs.

Published
2009
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46. Global distribution of Mycobacterium tuberculosis spoligotypes. (Dispatches)

Author

Filliol, Ingrid, Driscoll, Jeffrey R., van Soolingen, Dick, Kreiswirth, Barry N., Kremer, Kristin, Valetudie, Georges, Anh, Dang Duc, Barlow, Rachael, Banerjee, Dilip, Bifani, Pablo J., Brudey, Karine, Cataldi, Angel, Cooksey, Robert C., Cousins, Debby V., Dale, Jeremy W., Dellagostin, Odir A., Drobniewski, Francis, Engelmann, Guido, Ferdinand, Severine, GascoyneBinzi, Deborah, Gordon, Max, Gutierrez, M. Cristina, Haas, Walter H., Heersma, Herre, Kallenius, Gunilla, Kassa-Kelembho, Eric, Koivula, Tuija, Ly, Ho Minh, Makristathis, Athanasios, Mammina, Caterina, Martin, Gerald, Mostrom, Peter, Mokrousov, Igor, Narbonne, Valerie, Narvskaya, Olga, Nastasi, Antonino, Niobe-Eyangoh, Sara Ngo, Pape, Jean W, Rasolofo-Razanamparany, Voahangy, Ridell, Malin, Rossetti, M. Lucia, Stauffer, Fritz, Suffys, Philip N., Takiff, Howard, Texier-Maugein, Jeanne, Vincent, Veronique, de Waard, Jacobus H., Sola, Christophe, and Rastogi, Nalin

Subjects
CD-ROM catalog, CD-ROM database, Database, Tuberculosis -- Research, Tuberculosis -- Physiological aspects, Mycobacteria -- Physiological aspects, Mycobacteria -- Research, Mycobacterium, Databases -- Usage
Abstract

We present a short summary of recent observations on the global distribution of the major clades of the Mycobacterium tuberculosis complex, the causative agent of tuberculosis. This global distribution was [...]

Published
2002

48. Analysis of resistance genes in Candida albicans and Candida glabrata using Next Generation Sequencing

Author

Spettel, Kathrin, Barousch, Wolfgang, Makristathis, Athanasios, Hirschl, Alexander, Nehr, Marion, Selitsch, Brigitte, Michaela, Lackner, Rath, Peter-Michael, Steinmann, Jörg, and Willinger, Birgit

Subjects
ddc: 610, Medizin, 610 Medical sciences, Medicine
Abstract

Due to the rising number of immunocompromised patients in recent decades, the risk of fungal opportunistic infections has increased. Candida is the fifth most common pathogen in nosocomial sepsis, which is associated with a high mortality rate. Additionally, an increase in antifungal-resistant Candida[for full text, please go to the a.m. URL], Frühjahrstagung der Sektion Antimykotische Chemotherapie 2017

Published
2017

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