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840 results on '"Makino, Shinji"'

1. Multiple ocular manifestations in a case of cat scratch disease without systemic signs

Author

Annoura, Kanako, Sano, Ichiya, Makino, Shinji, and Kawashima, Hidetoshi

Subjects
cat scratch disease, anterior uveitis, serous macular detachment, Ophthalmology, RE1-994
Abstract

A 43-year-old woman presented with impaired vision and redness in her left eye of 2 weeks duration. She had a pet cat that scratched her forehead 3 weeks before she presented to us. She had no systemic signs such as lymphadenopathy, fever, or fatigue. The respective right and left corrected visual acuities were 20/16 and 20/2000. The anterior chamber of the left eye exhibited inflammation; a fundus examination of that eye revealed optic disc swelling and a serous macular detachment with hard stellate exudates. Based on the recent cat scratch and the ocular findings, cat scratch disease (CSD) was suspected. The results of serologic testing showed elevated titres of IgM and IgG antibodies to . Administration of doxycycline and a steroid was initiated. This report describes the occurrence of multiple ocular manifestations of CSD in both the posterior and the anterior segment.

Published
2020
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4. HSP90 is part of a protein complex with the L polymerase of Rift Valley fever phlebovirus and prevents its degradation by the proteasome during the viral genome replication/transcription stage

Author

Alem, Farhang, primary, Brahms, Ashwini, additional, Tarasaki, Kaori, additional, Omole, Samson, additional, Kehn-Hall, Kylene, additional, Schmaljohn, Connie S., additional, Bavari, Sina, additional, Makino, Shinji, additional, and Hakami, Ramin M., additional

Published
2024
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10. An Infectious cDNA Clone of SARS-CoV-2

Author

Xie, Xuping, Muruato, Antonio, Lokugamage, Kumari G., Narayanan, Krishna, Zhang, Xianwen, Zou, Jing, Liu, Jianying, Schindewolf, Craig, Bopp, Nathen E., Aguilar, Patricia V., Plante, Kenneth S., Weaver, Scott C., Makino, Shinji, LeDuc, James W., Menachery, Vineet D., and Shi, Pei-Yong

Published
2020
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12. Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States

Author

Harcourt, Jennifer, Tamin, Azaibi, Lu, Xiaoyan, Kamili, Shifaq, Sakthivel, Senthil K., Murray, Janna, Queen, Krista, Tao, Ying, Paden, Clinton R., Zhang, Jing, Li, Yan, Uehara, Anna, Wang, Haibin, Goldsmith, Cynthia, Bullock, Hannah A., Wang, Lijuan, Whitaker, Brett, Lynch, Brian, Gautam, Rashi, Schindewolf, Craig, Lokugamage, Kumari G., Scharton, Dionna, Plante, Jessica A., Mirchandani, Divya, Widen, Steven G., Narayanan, Krishna, Makino, Shinji, Ksiazek, Thomas G., Plante, Kenneth S., Weaver, Scott C., Lindstrom, Stephen, Tong, Suxiang, Menachery, Vineet D., and Thornburg, Natalie J.

Subjects
United States. Centers for Disease Control and Prevention, Severe acute respiratory syndrome, Coronaviruses, Health
Abstract

A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been identified as the source of a pneumonia outbreak in Wuhan, China, in late 2019 (2,2). The virus was [...]

Published
2020
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21. A structural analysis of M protein in coronavirus assembly and morphology

Author

Neuman, Benjamin W, Kiss, Gabriella, Kunding, Andreas H, Bhella, David, Baksh, M Fazil, Connelly, Stephen, Droese, Ben, Klaus, Joseph P, Makino, Shinji, Sawicki, Stanley G, Siddell, Stuart G, Stamou, Dimitrios G, Wilson, Ian A, Kuhn, Peter, and Buchmeier, Michael J

Subjects
Emerging Infectious Diseases, Vaccine Related, Infectious Diseases, 2.2 Factors relating to the physical environment, Aetiology, Infection, Cell Line, Coronavirus, Coronavirus M Proteins, Cryoelectron Microscopy, Electron Microscope Tomography, Humans, Viral Matrix Proteins, Virus Assembly, Cryo-electron microscopy, Cryo-electron tomography, Pleomorphic virus structure, Viral matrix protein, Biochemistry and Cell Biology, Zoology, Biophysics
Abstract

The M protein of coronavirus plays a central role in virus assembly, turning cellular membranes into workshops where virus and host factors come together to make new virus particles. We investigated how M structure and organization is related to virus shape and size using cryo-electron microscopy, tomography and statistical analysis. We present evidence that suggests M can adopt two conformations and that membrane curvature is regulated by one M conformer. Elongated M protein is associated with rigidity, clusters of spikes and a relatively narrow range of membrane curvature. In contrast, compact M protein is associated with flexibility and low spike density. Analysis of several types of virus-like particles and virions revealed that S protein, N protein and genomic RNA each help to regulate virion size and variation, presumably through interactions with M. These findings provide insight into how M protein functions to promote virus assembly.

Published
2011

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