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3. Association of arterial stiffness with kidney function among adults without chronic kidney disease

Author

Itano, Seiji, Yano, Yuichiro, Nagasu, Hajime, Tomiyama, Hirofumi, Kanegae, Hiroshi, Makino, Hirofumi, Higashi, Yukihito, Kobayashi, Yusuke, Sogawa, Yuji, Satoh, Minoru, Suzuki, Kenji, Townsend, Raymond R, Budoff, Matthew, Bakris, George, and Kashihara, Naoki

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Kidney Disease, Clinical Research, Renal and urogenital, Ankle Brachial Index, Disease Progression, Female, Glomerular Filtration Rate, Humans, Hypertension, Japan, Kidney, Kidney Function Tests, Male, Medical Records, Problem-Oriented, Middle Aged, Prognosis, Renal Insufficiency, Chronic, Retrospective Studies, Risk Assessment, Vascular Stiffness, arterial stiffness, blood pressure, cardio-ankle vascular index, chronic kidney disease, hypertension, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundOur aims were to assess whether arterial stiffness is associated with a higher risk for kidney dysfunction among persons without chronic kidney disease (CKD).MethodsWe analyzed data from the national health checkup system in Japan; for our analyses, we selected records of individuals who completed assessments of cardio-ankle vascular index (CAVI) and kidney function from 2005 to 2016. We excluded participants who had CKD at baseline, defined as the presence of proteinuria or estimated glomerular filtration rate (eGFR)

Published
2020

4. The efficacy and safety of mizoribine for maintenance therapy in patients with myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis: the usefulness of serum mizoribine monitoring

Author

Mase, Kaori, Saito, Chie, Usui, Joichi, Arimura, Yoshihiro, Nitta, Kosaku, Wada, Takashi, Makino, Hirofumi, Muso, Eri, Hirawa, Nobuhito, Kobayashi, Masaki, Yumura, Wako, Fujimoto, Shouichi, Nakagawa, Naoki, Ito, Takafumi, Yuzawa, Yukio, Matsuo, Seiichi, and Yamagata, Kunihiro

Published
2022
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7. Change in Albuminuria and GFR Slope as Joint Surrogate End Points for Kidney Failure: Implications for Phase 2 Clinical Trials in CKD

Author

Heerspink, Hiddo J.L., Inker, Lesley A., Tighiouart, Hocine, Collier, Willem H., Haaland, Benjamin, Luo, Jiyu, Appel, Gerald B., Chan, Tak Mao, Estacio, Raymond O., Fervenza, Fernando, Floege, Jürgen, Imai, Enyu, Jafar, Tazeen H., Lewis, Julia B., Kam-Tao Li, Philip, Locatelli, Francesco, Maes, Bart D., Perna, Annalisa, Perrone, Ronald D., Praga, Manuel, Schena, Francesco P., Wanner, Christoph, Xie, Di, Greene, Tom, Schrier, Robert W., Hanratty, Rebecca, Maschio, Giuseppe, Carlo, Manno, Saddelli, Mauro, Brenner, Barry M., Lewis, Edmund, von Eynatten, Maximilian, de Jong, Paul E., van Essen, GG, Hou, Fan Fan, Chapman, Arlene, Torres, Vicente, Yu, Alan, Brosnahan, Godela, Chow, Kai-Ming, Szeto, Cheuk-Chun, Leung, Chi-Bon, Hunsicker, Lawrence G., Dwyer, Jamie, Pohl, Marc, Raz, Itamar, Del Vecchio, Lucia, Andrulli, Simeone, Pozzi, Claudio, Casartelli, Donatella, Malfait, Thomas, Vanacker, An, Caravaca-Fontán, Fernando, Trujillo, Hernando, Cavero, Teresa, Gutierrez, Eduardo, Beck, Gerald, Kusek, John, Eknoyan, Garabed, Ponticelli, Claudio, Montagnino, Giuseppe, Passerini, Patrizia, Moroni, Gabriella, Kobayashi, Fumiaki, Makino, Hirofumi, Ito, Sadayoshi, Chan, Juliana CN, Tang, Colin, Gaspari, Flavio, Lesti, Maria Domenica, Gherardi, Giulia, Gamba, Sara, Keane, William, Donadio, James, Rauen, Thomas, Seikrit, Claudia, Wied, Stefanie, Dwyer, Jamie, and Becker, Gavin J.

Published
2023
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8. Low disease activity of microscopic polyangiitis in patients with anti-myosin light chain 6 antibody that disrupts actin rearrangement necessary for neutrophil extracellular trap formation

Author

Yoshinari, Miku, Nishibata, Yuka, Masuda, Sakiko, Nakazawa, Daigo, Tomaru, Utano, Arimura, Yoshihiro, Amano, Koichi, Yuzawa, Yukio, Sada, Ken-Ei, Atsumi, Tatsuya, Dobashi, Hiroaki, Hasegawa, Hitoshi, Harigai, Masayoshi, Matsuo, Seiichi, Makino, Hirofumi, and Ishizu, Akihiro

Published
2022
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11. Evaluation of Ministry of Health, Labour and Welfare diagnostic criteria for antineutrophil cytoplasmic antibody–associated vasculitis compared to ACR/EULAR 2022 classification criteria.

Author

Sada, Ken-ei, Nagasaka, Kenji, Kaname, Shinya, Higuchi, Tomoaki, Furuta, Shunsuke, Nanki, Toshihiro, Tsuboi, Naotake, Amano, Koichi, Dobashi, Hiroaki, Hiromura, Keiju, Bando, Masashi, Wada, Takashi, Arimura, Yoshihiro, Makino, Hirofumi, and Harigai, Masayoshi

Subjects
CHURG-Strauss syndrome, MICROSCOPIC polyangiitis, VASCULITIS, CLASSIFICATION, ANTINEUTROPHIL cytoplasmic antibodies
Abstract

Objective: This study aimed to evaluate the Ministry of Health, Labour and Welfare (MHLW) diagnostic criteria for antineutrophil cytoplasmic antibody–associated vasculitis compared to the new American College of Rheumatology/European Alliance of Associations for Rheumatology 2022 criteria. Methods: Two nationwide cohort studies were used, and participants were categorised as having eosinophilic granulomatosis with polyangiitis, granulomatosis with polyangiitis (GPA), or microscopic polyangiitis (MPA) according to the American College of Rheumatology/European Alliance of Associations for Rheumatology 2022 and MHLW criteria. Results: Of the entire patient population, only 10 (2.1%) were unclassifiable according to the MHLW probable criteria, while a significant number of patients (71.3%) met at least two criteria. The MHLW probable criteria for MPA had some challenges in differentiating between MPA and eosinophilic granulomatosis with polyangiitis, and the same was true for MHLW probable criteria for GPA in differentiating MPA from GPA. Nevertheless, improved classification results were obtained when the MHLW probable criteria were applied in the order of eosinophilic granulomatosis with polyangiitis, MPA, and GPA. Conclusions: The application of MHLW criteria could categorise a substantial number of patients with antineutrophil cytoplasmic antibody–associated vasculitis into one of the three antineutrophil cytoplasmic antibody–associated vasculitis diseases. The classification was in accordance with the American College of Rheumatology/European Alliance of Associations for Rheumatology 2022 criteria when considering the order of application. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Health-related quality of life in 10 years long-term survivors of chronic kidney disease: a From-J study

Author

Okubo, Reiko, primary, Kondo, Masahide, additional, Imasawa, Toshiyuki, additional, Saito, Chie, additional, Kai, Hirayasu, additional, Tsunoda, Ryoya, additional, Hoshino, Junichi, additional, Watanabe, Tsuyoshi, additional, Narita, Ichiei, additional, Matsuo, Seiichi, additional, Makino, Hirofumi, additional, Hishida, Akira, additional, and Yamagata, Kunihiro, additional

Published
2023
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14. Change in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies

Author

Appel, Lawrence J, Greene, Tom, Chen, Teresa K, Chalmers, John, Arima, Hisatomi, Perkovic, Vlado, Levin, Adeera, Djurdjev, Ognjenka, Tang, Mila, Nally, Joseph, Navaneethan, Sankar D, Schold, Jesse D, Weldegiorgis, Misghina, Herrington, William G, Smith, Margaret, Hsu, C Yenchih, Hwang, Shih-Jen, Chang, Alex R, Kirchner, H. Lester, Green, Jamie A, Ho, Kevin, Marks, Angharad, Prescott, Gordon, Clark, Laura E, Fluck, Nick, Shalev, Varda, Chodick, Gabriel, Blankestijn, Peter J, Van Zuilen, Arjan, Van den Brand, Jan A, Sarnak, Mark J, Bottinger, Erwin, Nadkarni, Girish N, Ellis, Stephen G, Nadukuru, Rajiv, Metzger, Marie, Flamant, Martin, Houillier, Pascal, Haymann, Jean-Philippe, Froissart, Marc, Kenealy, Timothy, Elley, Raina C, Collins, John F, Drury, Paul L, Cuddeback, John K, Ciemins, Elizabeth L, Stempniewicz, Rich, Nelson, Robert G, Knowler, William C, Bakker, Stephen J, Major, Rupert W, Medcalf, James F, Shepherd, David, Barrett-Connor, Elizabeth, Bergstrom, Jaclyn, Ix, Joachim H, Molnar, Miklos Z, Sumida, Keiichi, de Zeeuw, Dick, Brenner, Barry, Qureshi, Abdul R, Elinder, Carl-Gustaf, Runesson, Bjorn, Evans, Marie, Segelmark, Marten, Stendahl, Maria, Schön, Staffan, Naimark, David M, Tangri, Navdeep, Sud, Maneesh, Hirayama, Atsushi, Ichikawa, Kazunobu, Bilo, Henk JG, Landman, Gijs WD, Van Hateren, Kornelis JJ, Kleefstra, Nanne, Hallan, Stein I, Ballew, Shoshana H, Chen, Jingsha, Kwak, Lucia, Surapaneni, Aditya, Parving, Hans-Henrik, Rodby, Roger A., Rohde, Richard D, Lewis, Julia B, Lewis, Edmund, Perrone, Ronald D, Abebe, Kaleab Z, Hou, Fan F, Xie, Di, Hunsicker, Lawrence G, Imai, Enyu, Kobayashi, Fumiaki, Makino, Hirofumi, Ito, Sadayoshi, Remuzzi, Giuseppe, Ruggenenti, Piero, Eckardt, Kai-Uwe, Gudmundsdottir, Hrefna, Maciulaitis, Romaldas, Manley, Tom, Smith, Kimberly, Stockbridge, Norman, Thompson, Aliza, Vetter, Thorsten, Willis, Kerry, Zhang, Luxia, Coresh, Josef, Heerspink, Hiddo J L, Sang, Yingying, Matsushita, Kunihiro, Arnlov, Johan, Astor, Brad C, Black, Corri, Brunskill, Nigel J, Carrero, Juan-Jesus, Feldman, Harold I, Fox, Caroline S, Inker, Lesley A, Ishani, Areef, Jassal, Simerjot, Konta, Tsuneo, Polkinghorne, Kevan, Romundstad, Solfrid, Solbu, Marit D, Stempniewicz, Nikita, Stengel, Benedicte, Tonelli, Marcello, Umesawa, Mitsumasa, Waikar, Sushrut S, Wen, Chi-Pang, Wetzels, Jack F M, Woodward, Mark, Grams, Morgan E, Kovesdy, Csaba P, Levey, Andrew S, and Gansevoort, Ron T

Published
2019
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15. Change in albuminuria as a surrogate endpoint for progression of kidney disease: a meta-analysis of treatment effects in randomised clinical trials

Author

Sevillano, Angel, Kamper, Anne-Lise, van Zuilen, Arjan D., Brenner, Barry M., Maes, Bart, Ihle, Benno U., Barret, Brendan, Leung, CB, Szeto, CC, Fitzner, Christina, Wanner, Christoph, Pozzi, Claudio, Montagnino, Claudio Ponticelli, Xie, Di, de Zeeuw, Dick, Lewis, Edmund, Verde, Eduardo, Gutierrez, Eduardo, Imai, Enyu, Hou, Fan Fan, Caravaca, Fernando, Fervenza, Fernando C., Locatelli, Francesco, Schena, Francesco Paolo, Kobayashi, Fumiaki, Moroni, Gabriella, Becker, Gavin J., Beck, Gerald J., Appel, Gerald B., Frisch, Gershon, van Essen, GG, Maschio, Giuseppe, Remuzzi, Giuseppe, Montogrino, Giuseppe, Parving, Hans-Henrik, Heerspink, Hiddo J.L., Makino, Hirofumi, Jehan, Imitiaz, Wetzels, Jack F.M., Donadio, James, Dwyer, Jamie, van den Brand, Jan, Kusek, John, Lachin, John M., Luño, Jose, Lewis, Julia B., Floege, Jürgen, Abebe, Kaleab Z., Chow, KM, Hunsicker, Lawrence G., del Vecchio, Lucia, Carlo, Manno, Praga, Manuel, Goicoechea, Marian, von Eynatten, Maximilian, Poulter, Neil, Chaturvedi, Nish, Passerini, Patrizia, de Jong, Paul E., Blankestijn, Peter J., Li, Philip, Ruggenenti, Piero, Zucchelli, Pietro, Kincaid-Smith, Priscilla S., Hilgers, Ralf-Dieter, Estacio, Raymond O., Rohde, Richard D., Katafuchi, Ritsuko, Toto, Robert D., Schrier, Robert W., Rodby, Roger A., Perrone, Ronald D., Ito, Sadayoshi, Klahr, Saulo, Andrulli, Simeone, Strandgaard, Svend, Chan, Tak Mao, Hannedouche, Thierry P., Rauen, Thomas, Greene, Tom, Verdalles, Ursula, Perkovic, Vlado, Keane, William, Heerspink, Hiddo J L, Tighiouart, Hocine, Gansevoort, Ron T, Coresh, Josef, Simon, Andrew L, Lewis, Julia B, Levey, Andrew S, and Inker, Lesley A

Published
2019
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16. Validation of new ACR/EULAR 2022 classification criteria for anti-neutrophil cytoplasmic antibody–associated vasculitis.

Author

Sada, Ken-ei, Kaname, Shinya, Higuchi, Tomoaki, Furuta, Shunsuke, Nagasaka, Kenji, Nanki, Toshihiro, Tsuboi, Naotake, Amano, Koichi, Dobashi, Hiroaki, Hiromura, Keiju, Bando, Masashi, Wada, Takashi, Arimura, Yoshihiro, Makino, Hirofumi, and Harigai, Masayoshi

Subjects
CHURG-Strauss syndrome, MICROSCOPIC polyangiitis, INTERSTITIAL lung diseases, VASCULITIS, CLASSIFICATION algorithms
Abstract

Objective: The objective of this study was to compare the American College of Rheumatology/European Alliance of Associations for Rheumatology 2022 criteria with the previous classification algorithm for anti-neutrophil cytoplasmic antibody–associated vasculitis. Methods: We used data from two nationwide, prospective, inception cohort studies. The enrolled patients were classified as having eosinophilic granulomatosis with polyangiitis (EGPA), granulomatosis with polyangiitis (GPA), or microscopic polyangiitis (MPA) according to the new criteria; these criteria were compared with Watts' algorithm. Results: Among 477 patients, 10.7%, 9.9%, and 75.6% were classified as having EGPA, GPA, and MPA, respectively; 6.1% were unclassifiable. Three patients met both the EGPA and MPA criteria, and eight patients met both the GPA and MPA criteria. Of 78 patients with GPA classified using Watts' algorithm, 27 (34.6%) patients were reclassified as having MPA. Ear, nose, and throat involvement was significantly less frequent in patients reclassified as having MPA than in those reclassified as having GPA. Of 73 patients unclassifiable using Watts' algorithm, 62 were reclassified as having MPA. All patients reclassified as having MPA were myeloperoxidase-anti-neutrophil cytoplasmic antibody positive, and 46 had interstitial lung disease. Conclusion: Although the American College of Rheumatology/European Alliance of Associations for Rheumatology 2022 criteria cause overlapping multiple criteria fulfilments in some patients, those items contribute to classifying unclassifiable patients using Watts' algorithm into MPA. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study

Author

Yamagata, Kunihiro, Usui, Joichi, Nagata, Michio, Sugiyama, Hitoshi, Sada, Ken-ei, Muso, Eri, Harigai, Masayoshi, Amano, Koichi, Atsumi, Tatsuya, Fujimoto, Shouichi, Yuzawa, Yukio, Kobayashi, Masaki, Saito, Takao, Ito, Takafumi, Hirawa, Nobuhito, Homma, Sakae, Dobashi, Hiroaki, Tsuboi, Naotaka, Ishizu, Akihiro, Arimura, Yoshihiro, Makino, Hirofumi, Matsuo, Seiichi, and For the Research Committee of Intractable Renal Disease and the Research Committee of Intractable Vasculitis Syndrome of the Ministry of Health, Labour, and Welfare of Japan

Published
2019
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23. Association of TERT and DSP variants with microscopic polyangiitis and myeloperoxidase-ANCA positive vasculitis in a Japanese population: a genetic association study

Author

Kawasaki, Aya, Namba, Natsumi, Sada, Ken-ei, Hirano, Fumio, Kobayashi, Shigeto, Nagasaka, Kenji, Sugihara, Takahiko, Ono, Nobuyuki, Fujimoto, Takashi, Kusaoi, Makio, Tamura, Naoto, Yamagata, Kunihiro, Sumida, Takayuki, Hashimoto, Hiroshi, Ozaki, Shoichi, Makino, Hirofumi, Arimura, Yoshihiro, Harigai, Masayoshi, and Tsuchiya, Naoyuki

Published
2020
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24. Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial

Author

Haneda, Masakazu, Iwashima, Yasunori, Suda, Toshihiro, Tamasawa, Naoki, Daimon, Makoto, Satoh, Jo, Takebe, Noriko, Ishigaki, Yasushi, Watanabe, Tsuyoshi, Satoh, Hiroaki, Kasai, Kikuo, Aso, Yoshimasa, Ishibashi, Shun, Katayama, Shigehiro, Ishikawa, San-e, Kakei, Masafumi, Namai, Kazuyuki, Hashimoto, Naotake, Suzuki, Yoshifumi, Onishi, Shunichiro, Yokote, Koutaro, Matsuda, Masafumi, Masuzawa, Masahiro, Hayashi, Yoichi, Saito, Satoshi, Ogihara, Norikazu, Ishihara, Hisamitsu, Tajima, Naoko, Utsunomiya, Kazunori, Shimada, Akira, Itoh, Hiroshi, Kawamori, Ryuzo, Watada, Hirotaka, Hayashi, Michio, Mori, Yasumichi, Shiba, Teruo, Isogawa, Akihiro, Sakura, Hiroshi, Odawara, Masato, Tobe, Kazuyuki, Tsukamoto, Kazuhisa, Yamauchi, Toshimasa, Teramoto, Tamio, Hirata, Yukio, Uchimura, Isao, Ogawa, Yoshihiro, Yoshino, Gen, Hirose, Takahisa, Kajio, Hiroshi, Atsumi, Yoshihito, Oikawa, Yoichi, Araki, Atsushi, Ueki, Akio, Ohno, Atsushi, Kitaoka, Masafumi, Fujita, Yoshikuni, Moriya, Tatsumi, Tojo, Taiki, Shichiri, Masayoshi, Suzuki, Daisuke, Toyoda, Masao, Hamano, Kumiko, Komi, Rieko, Terauchi, Yasuo, Kuzuya, Nobuaki, Yamada, Masayo, Takamura, Toshinari, Imura, Mitsuo, Tanaka, Hiroshi, Hayashi, Masayuki, Kato, Yasuhisa, Itoh, Mitsuyasu, Suzuki, Atsushi, Nakayama, Mikihiro, Sano, Takahisa, Nakashima, Eitaro, Sumida, Yasuhiro, Yano, Yutaka, Tanaka, Tsuyoshi, Murata, Kazuya, Kashiwagi, Atsunori, Maegawa, Hiroshi, Kono, Shigeo, Inagaki, Nobuya, Kosugi, Keisuke, Yasuda, Tetsuyuki, Yoshimasa, Yasunao, Kishimoto, Ichiro, Sato, Toshihiko, Hosoi, Masayuki, Yamasaki, Tomoyuki, Matsuhisa, Munehide, Shimomura, Iichiro, Taniguchi, Ataru, Kuroe, Akira, Kurose, Takeshi, Ohara, Takeshi, Sakaguchi, Kazuhiko, Namba, Mitsuyoshi, Kaku, Kohei, Fujiwara, Masazumi, Shimizu, Ikki, Ono, Keizo, Ebisui, Osamu, Tanizawa, Yukio, Okada, Yosuke, Natori, Shoichi, Kodera, Takehiko, Sato, Naoichi, Ide, Makoto, Yamada, Kentaro, Umeda, Fumio, Eto, Tomoaki, Mimura, Kazuo, Hiramatsu, Shinsuke, Inoue, Tomoaki, Takei, Ryoko, Ogo, Atsushi, Eguchi, Katsumi, Kawasaki, Eiji, Koide, Yuji, Araki, Eiichi, Jinnouchi, Hideaki, Yamamoto, Hiroaki, Motoyoshi, Mitsutaka, Hiyoshi, Toru, Tanaka, Yasushi, Momoki, Tadahisa, Sato, Koichiro, Yoneyama, Akihiko, Ito, Kenichi, Sobajima, Hiroshi, Ikegami, Hiroshi, Ikeda, Masaki, Ikeda, Hiroki, Takahashi, Kenji, Makino, Hirofumi, Ueda, Yasuo, Nakazato, Masamitsu, Ueki, Kohjiro, Sasako, Takayoshi, Okazaki, Yukiko, Kato, Masayuki, Okahata, Sumie, Katsuyama, Hisayuki, Haraguchi, Mikiko, Morita, Ai, Ohashi, Ken, Hara, Kazuo, Morise, Atsushi, Izumi, Kazuo, Ishizuka, Naoki, Ohashi, Yasuo, Noda, Mitsuhiko, and Kadowaki, Takashi

Published
2017
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26. The Effect of Medical Cooperation in the CKD Patients: 10-Year Multicenter Cohort Study

Author

Onishi, Yasuhiro, Uchida, Haruhito A., Maeshima, Yohei, Okuyama, Yuka, Otaka, Nozomu, Ujike, Haruyo, Tanaka, Keiko, Takeuchi, Hidemi, Tsuji, Kenji, Kitagawa, Masashi, Tanabe, Katsuyuki, Morinaga, Hiroshi, Kinomura, Masaru, Kitamura, Shinji, Sugiyama, Hitoshi, Ota, Kosuke, Maruyama, Keisuke, Hiramatsu, Makoto, Oshiro, Yoshiyuki, Morioka, Shigeru, Takiue, Keiichi, Omori, Kazuyoshi, Fukushima, Masaki, Gamou, Naoyuki, Hirata, Hiroshi, Sato, Ryosuke, Makino, Hirofumi, Wada, Jun, Onishi, Yasuhiro, Uchida, Haruhito A., Maeshima, Yohei, Okuyama, Yuka, Otaka, Nozomu, Ujike, Haruyo, Tanaka, Keiko, Takeuchi, Hidemi, Tsuji, Kenji, Kitagawa, Masashi, Tanabe, Katsuyuki, Morinaga, Hiroshi, Kinomura, Masaru, Kitamura, Shinji, Sugiyama, Hitoshi, Ota, Kosuke, Maruyama, Keisuke, Hiramatsu, Makoto, Oshiro, Yoshiyuki, Morioka, Shigeru, Takiue, Keiichi, Omori, Kazuyoshi, Fukushima, Masaki, Gamou, Naoyuki, Hirata, Hiroshi, Sato, Ryosuke, Makino, Hirofumi, and Wada, Jun

Abstract

Introduction: While chronic kidney disease (CKD) is one of the most important contributors to mortality from non-communicable diseases, the number of nephrologists is limited worldwide. Medical cooperation is a system of cooperation between primary care physicians and nephrological institutions, consisting of nephrologists and multidisciplinary care teams. Although it has been reported that multidisciplinary care teams contribute to the prevention of worsening renal functions and cardiovascular events, there are few studies on the effect of a medical cooperation system. Methods: We aimed to evaluate the effect of medical cooperation on all-cause mortality and renal prognosis in patients with CKD. One hundred and sixty-eight patients who visited the one hundred and sixty-three clinics and seven general hospitals of Okayama city were recruited between December 2009 and September 2016, and one hundred twenty-three patients were classified into a medical cooperation group. The outcome was defined as the incidence of all-cause mortality, or renal composite outcome (end-stage renal disease or 50% eGFR decline). We evaluated the effects on renal composite outcome and pre-ESRD mortality while incorporating the competing risk for the alternate outcome into a Fine-Gray subdistribution hazard model. Results: The medical cooperation group had more patients with glomerulonephritis (35.0% vs. 2.2%) and less nephrosclerosis (35.0% vs. 64.5%) than the primary care group. Throughout the follow-up period of 5.59 +/- 2.78 years, 23 participants (13.7%) died, 41 participants (24.4%) reached 50% decline in eGFR, and 37 participants (22.0%) developed end-stage renal disease (ESRD). All-cause mortality was significantly reduced by medical cooperation (sHR 0.297, 95% CI 0.105-0.835, p = 0.021). However, there was a significant association between medical cooperation and CKD progression (sHR 3.069, 95% CI 1.225-7.687, p = 0.017). Conclusion: We evaluated mortality and ESRD using a CKD cohor

Published
2023

28. Association of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not with ANCA-associated vasculitis in a Japanese population

Author

Yokoyama, Nozomi, Kawasaki, Aya, Matsushita, Takashi, Furukawa, Hiroshi, Kondo, Yuya, Hirano, Fumio, Sada, Ken-ei, Matsumoto, Isao, Kusaoi, Makio, Amano, Hirofumi, Nagaoka, Shouhei, Setoguchi, Keigo, Nagai, Tatsuo, Shimada, Kota, Sugii, Shoji, Hashimoto, Atsushi, Matsui, Toshihiro, Okamoto, Akira, Chiba, Noriyuki, Suematsu, Eiichi, Ohno, Shigeru, Katayama, Masao, Migita, Kiyoshi, Kono, Hajime, Hasegawa, Minoru, Kobayashi, Shigeto, Yamada, Hidehiro, Nagasaka, Kenji, Sugihara, Takahiko, Yamagata, Kunihiro, Ozaki, Shoichi, Tamura, Naoto, Takasaki, Yoshinari, Hashimoto, Hiroshi, Makino, Hirofumi, Arimura, Yoshihiro, Harigai, Masayoshi, Sato, Shinichi, Sumida, Takayuki, Tohma, Shigeto, Takehara, Kazuhiko, and Tsuchiya, Naoyuki

Published
2019
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31. Nationwide multicenter kidney biopsy study of Japanese patients with hypertensive nephrosclerosis

Author

Furuichi, Kengo, Shimizu, Miho, Yuzawa, Yukio, Hara, Akinori, Toyama, Tadashi, Kitamura, Hiroshi, Suzuki, Yoshiki, Sato, Hiroshi, Uesugi, Noriko, Ubara, Yoshifumi, Hoshino, Junichi, Hisano, Satoshi, Ueda, Yoshihiko, Nishi, Shinichi, Yokoyama, Hitoshi, Nishino, Tomoya, Kohagura, Kentaro, Ogawa, Daisuke, Mise, Koki, Shibagaki, Yugo, Kimura, Kenjiro, Haneda, Masakazu, Makino, Hirofumi, Matsuo, Seiichi, Wada, Takashi, and Research Group of Diabetic Nephropathy and Nephrosclerosis, Ministry of Health, Labour and Welfare of Japan, and Japan Agency for Medical Research and Development

Published
2018
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32. Clinicopathological analysis of biopsy-proven diabetic nephropathy based on the Japanese classification of diabetic nephropathy

Author

Furuichi, Kengo, Shimizu, Miho, Yuzawa, Yukio, Hara, Akinori, Toyama, Tadashi, Kitamura, Hiroshi, Suzuki, Yoshiki, Sato, Hiroshi, Uesugi, Noriko, Ubara, Yoshifumi, Hohino, Junichi, Hisano, Satoshi, Ueda, Yoshihiko, Nishi, Shinichi, Yokoyama, Hitoshi, Nishino, Tomoya, Kohagura, Kentaro, Ogawa, Daisuke, Mise, Koki, Shibagaki, Yugo, Makino, Hirofumi, Matsuo, Seiichi, Wada, Takashi, and Research Group of Diabetic Nephropathy, Ministry of Health, Labour and Welfare of Japan, and Japan Agency for Medical Research and Development

Published
2018
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33. Association of ETS1 polymorphism with granulomatosis with polyangiitis and proteinase 3-anti-neutrophil cytoplasmic antibody positive vasculitis in a Japanese population

Author

Kawasaki, Aya, Yamashita, Keita, Hirano, Fumio, Sada, Ken-ei, Tsukui, Daisuke, Kondo, Yuya, Kimura, Yoshitaka, Asako, Kurumi, Kobayashi, Shigeto, Yamada, Hidehiro, Furukawa, Hiroshi, Nagasaka, Kenji, Sugihara, Takahiko, Yamagata, Kunihiro, Sumida, Takayuki, Tohma, Shigeto, Kono, Hajime, Ozaki, Shoichi, Matsuo, Seiichi, Hashimoto, Hiroshi, Makino, Hirofumi, Arimura, Yoshihiro, Harigai, Masayoshi, and Tsuchiya, Naoyuki

Published
2018
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34. The Effect of Medical Cooperation in the CKD Patients: 10-Year Multicenter Cohort Study

Author

Onishi, Yasuhiro, primary, Uchida, Haruhito A., additional, Maeshima, Yohei, additional, Okuyama, Yuka, additional, Otaka, Nozomu, additional, Ujike, Haruyo, additional, Tanaka, Keiko, additional, Takeuchi, Hidemi, additional, Tsuji, Kenji, additional, Kitagawa, Masashi, additional, Tanabe, Katsuyuki, additional, Morinaga, Hiroshi, additional, Kinomura, Masaru, additional, Kitamura, Shinji, additional, Sugiyama, Hitoshi, additional, Ota, Kosuke, additional, Maruyama, Keisuke, additional, Hiramatsu, Makoto, additional, Oshiro, Yoshiyuki, additional, Morioka, Shigeru, additional, Takiue, Keiichi, additional, Omori, Kazuyoshi, additional, Fukushima, Masaki, additional, Gamou, Naoyuki, additional, Hirata, Hiroshi, additional, Sato, Ryosuke, additional, Makino, Hirofumi, additional, and Wada, Jun, additional

Published
2023
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35. Association of HLA-class II alleles with risk of relapse in myeloperoxidase-antineutrophil cytoplasmic antibody positive vasculitis in the Japanese population

Author

Kawasaki, Aya, primary, Sada, Ken-ei, additional, Kusumawati, Premita Ari, additional, Hirano, Fumio, additional, Kobayashi, Shigeto, additional, Nagasaka, Kenji, additional, Sugihara, Takahiko, additional, Ono, Nobuyuki, additional, Fujimoto, Takashi, additional, Kusaoi, Makio, additional, Tamura, Naoto, additional, Kusanagi, Yasuyoshi, additional, Itoh, Kenji, additional, Sumida, Takayuki, additional, Yamagata, Kunihiro, additional, Hashimoto, Hiroshi, additional, Makino, Hirofumi, additional, Arimura, Yoshihiro, additional, Harigai, Masayoshi, additional, and Tsuchiya, Naoyuki, additional

Published
2023
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36. Sex differences in risk factors for end‐stage kidney disease and death in type 2 diabetes: A retrospective cohort study

Author

Oshima, Megumi, primary, Iwata, Yasunori, additional, Toyama, Tadashi, additional, Kitajima, Shinji, additional, Hara, Akinori, additional, Sakai, Norihiko, additional, Shimizu, Miho, additional, Furuichi, Kengo, additional, Haneda, Masakazu, additional, Babazono, Tetsuya, additional, Yokoyama, Hiroki, additional, Iseki, Kunitoshi, additional, Araki, Shinichi, additional, Ninomiya, Toshiharu, additional, Hara, Shigeko, additional, Suzuki, Yoshiki, additional, Iwano, Masayuki, additional, Kusano, Eiji, additional, Moriya, Tatsumi, additional, Satoh, Hiroaki, additional, Nakamura, Hiroyuki, additional, Makino, Hirofumi, additional, and Wada, Takashi, additional

Published
2023
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37. Validation of new ACR/EULAR 2022 classification criteria for anti-neutrophil cytoplasmic antibody–associated vasculitis

Author

Sada, Ken-ei, primary, Kaname, Shinya, additional, Higuchi, Tomoaki, additional, Furuta, Shunsuke, additional, Nagasaka, Kenji, additional, Nanki, Toshihiro, additional, Tsuboi, Naotake, additional, Amano, Koichi, additional, Dobashi, Hiroaki, additional, Hiromura, Keiju, additional, Bando, Masashi, additional, Wada, Takashi, additional, Arimura, Yoshihiro, additional, Makino, Hirofumi, additional, and Harigai, Masayoshi, additional

Published
2023
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38. Additional file 1 of Low disease activity of microscopic polyangiitis in patients with anti-myosin light chain 6 antibody that disrupts actin rearrangement necessary for neutrophil extracellular trap formation

Author

Yoshinari, Miku, Nishibata, Yuka, Masuda, Sakiko, Nakazawa, Daigo, Tomaru, Utano, Arimura, Yoshihiro, Amano, Koichi, Yuzawa, Yukio, Sada, Ken-Ei, Atsumi, Tatsuya, Dobashi, Hiroaki, Hasegawa, Hitoshi, Harigai, Masayoshi, Matsuo, Seiichi, Makino, Hirofumi, and Ishizu, Akihiro

Abstract

Additional file 1: Figure S1. Chronological G- and F-actin distribution in neutrophils stimulated by PMA. NETs were induced in peripheral blood neutrophils by 20 nM PMA. Before and 30 min, 1 h, and 3 h after incubation, the samples were fixed with 4% paraformaldehyde for 15 min and permeated with 0.5% Triton X-100 for 5 min at RT. Thereafter, the samples were reacted with 1:100 dilution of anti-β-actin mAb (mouse IgG1) at 4°C overnight. After rinsing with PBS, the samples were next reacted with 4 μg/mL Alexa Fluor 488-conjugated goat anti-mouse IgG1 antibody and 100 nM Acti-stain 555 phalloidin for 1 h at RT in the dark. The samples were finally mounted with the mounting solution containing DAPI. Anti-β-actin antibody recognizes G-actin, whereas phalloidin binds specifically to F-actin. Bar, 50 μm.

Published
2023
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39. Questionnaire Survey on COVID-19 Vaccination at Okayama University in Japan: Factors Promoting Vaccination Among Young Adults

Author

Higuchi, Chigusa, Matsumoto, Naomi, Iwasaki, Yoshiaki, Yorifuji, Takashi, Yamazaki, Junichiro, Nasu, Yasutomo, and Makino, Hirofumi

Subjects
young adults, satisfaction, vaccine hesitancy, information literacy, COVID-19 vaccine
Abstract

COVID-19 has been prevalent worldwide since 2019. Increasing COVID-19 vaccination coverage is an important measure to combat the disease. An online survey was conducted with university students and personnel who were vaccinated against COVID-19 at a mass vaccination event to examine the factors promoting vaccination among young adults. The online survey was conducted with persons vaccinated at Okayama University from June 5 to September 27, 2021. Although the number of those who had fever >37.5°C increased after the second vaccination compared to the first, the vaccinated persons got more satisfied after the second shot.

Published
2022

42. Association ofHLA-class IIalleles with risk of relapse in myeloperoxidase-antineutrophil cytoplasmic antibody positive vasculitis in the Japanese population

Author

Kawasaki, Aya, primary, Sada, Ken-ei, additional, Kusumawati, Premita Ari, additional, Hirano, Fumio, additional, Kobayashi, Shigeto, additional, Nagasaka, Kenji, additional, Sugihara, Takahiko, additional, Ono, Nobuyuki, additional, Fujimoto, Takashi, additional, Kusaoi, Makio, additional, Tamura, Naoto, additional, Kusanagi, Yasuyoshi, additional, Itoh, Kenji, additional, Sumida, Takayuki, additional, Yamagata, Kunihiro, additional, Hashimoto, Hiroshi, additional, Makino, Hirofumi, additional, Arimura, Yoshihiro, additional, Harigai, Masayoshi, additional, and Tsuchiya, Naoyuki, additional

Published
2022
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43. Successful Control of Hypercalcemia with Sorafenib, Evocalcet, and Denosumab Combination Therapy for Recurrent Parathyroid Carcinoma

Author

Makino, Hirofumi, primary, Notsu, Masakazu, additional, Asayama, Itsuko, additional, Otani, Hazuki, additional, Morita, Miwa, additional, Yamamoto, Masahiro, additional, Yamauchi, Mika, additional, Nakao, Mika, additional, Miyake, Hitomi, additional, Araki, Asuka, additional, Uchino, Shinya, additional, and Kanasaki, Keizo, additional

Published
2022
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45. Chemoprophylaxis against Pneumocystis jirovecii pneumonia in Japanese patients with ANCA-associated vasculitis: An observational study

Author

Nakaya, Izaya, primary, Sada, Ken-ei, additional, Harigai, Masayoshi, additional, Soma, Jun, additional, Amano, Koichi, additional, Dobashi, Hiroaki, additional, Atsumi, Tatsuya, additional, Yuzawa, Yukio, additional, Fujimoto, Shouichi, additional, Sugihara, Takahiko, additional, Takasaki, Yoshinari, additional, Arimura, Yoshihiro, additional, and Makino, Hirofumi, additional

Published
2022
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46. Longitudinal Assessment of the Effect of Atrasentan on Thoracic Bioimpedance in Diabetic Nephropathy: A Randomized, Double-Blind, Placebo-Controlled Trial

Author

Webb, David J., Coll, Blai, Heerspink, Hiddo J. L., Andress, Dennis, Pritchett, Yili, Brennan, John J., Houser, Mark, Correa-Rotter, Ricardo, Kohan, Donald, Makino, Hirofumi, Perkovic, Vlado, Remuzzi, Giuseppe, Tobe, Sheldon W., Toto, Robert, Busch, Robert, Pergola, Pablo, Parving, Hans-Henrik, and de Zeeuw, Dick

Published
2017
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48. Low disease activity of microscopic polyangiitis in patients with anti-myosin light chain 6 antibody that disrupts actin rearrangement necessary for neutrophil extracellular trap formation

Author

Yoshinari, Miku, primary, Nishibata, Yuka, additional, Masuda, Sakiko, additional, Nakazawa, Daigo, additional, Tomaru, Utano, additional, Arimura, Yoshihiro, additional, Amano, Koichi, additional, Yuzawa, Yukio, additional, Sada, Ken-Ei, additional, Atsumi, Tatsuya, additional, Dobashi, Hiroaki, additional, Hasegawa, Hitoshi, additional, Harigai, Masayoshi, additional, Takasaki, Yoshinari, additional, Saito, Masaya, additional, Matsuo, Seiichi, additional, Makino, Hirofumi, additional, and Ishizu, Akihiro, additional

Published
2022
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49. Organic Anion Transporter Gene Variants Associated With Plasma Exposure and Long‐Term Response to Atrasentan in Patients With Diabetic Kidney Disease

Author

Smeijer, J. David, primary, Koomen, Jeroen V., additional, Kohan, Donald E., additional, McMurray, John J. V., additional, Bakris, George L., additional, Correa‐Rotter, Ricardo, additional, Hou, Fan‐Fan, additional, Kitzman, Dalane W., additional, Makino, Hirofumi, additional, Mayer, Gert, additional, Nowicki, Michal, additional, Perkovic, Vlado, additional, Rossing, Peter, additional, Tobe, Sheldon, additional, Parving, Hans‐Henrik, additional, de Zeeuw, Dick, additional, and Heerspink, Hiddo J. L., additional

Published
2022
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