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Your search keyword '"Makaretz, Sara J."' showing total 15 results
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15 results on '"Makaretz, Sara J."'

2. Exploratory evaluation of 18F‐MK‐6240 tau PET positivity in TANGO phase 2 clinical trial of gosuranemab (BIIB092) in Mild Cognitive Impairment and mild Alzheimer’s disease

Author

Racine, Annie M, primary, Collins, Jessica A., additional, DuBois, Jonathan M, additional, Seibyl, John, additional, Kong, Jessica, additional, Li, Yumeng, additional, O'Gorman, John, additional, Makaretz, Sara J., additional, Jones, Stephanie, additional, Graham, Danielle, additional, Rajagovindan, Raj, additional, Shulman, Melanie, additional, and Haeberlein, Samantha Budd, additional

Published
2022
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3. Magnetic Resonance Imaging (MRI) Metrics in Routine Clinical Practice: Proof of Concept in MS PATHS (Multiple Sclerosis Partners Advancing Technology for Health Solutions) (1356)

Author

Fisher, Elizabeth, primary, Kober, Tobias, additional, Tsang, Adrian, additional, Corredor-Jerez, Ricardo, additional, Liao, Shirley, additional, Benzinger, Tammie L.S., additional, Blefari, Maria Laura, additional, Calabresi, Peter A., additional, Fartaria, Mario J., additional, Hersh, Carrie M., additional, Huelnhagen, Till, additional, Jones, Stephen E., additional, Kitzler, Hagen H., additional, Krupp, Lauren, additional, Levitt, Nicholas, additional, Lui, Yvonne W., additional, Makaretz, Sara J., additional, Naismith, Robert, additional, Nakamura, Kunio, additional, Ontaneda, Dan, additional, Perea, Rodrigo D., additional, Rao, Stephen, additional, Rovira, Alex, additional, Tivarus, Madalina E., additional, Williams, James R., additional, and Rudick, Richard A., additional

Published
2020
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7. Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson’s case

Author

Marquié, Marta, primary, Verwer, Eline E., additional, Meltzer, Avery C., additional, Kim, Sally Ji Who, additional, Agüero, Cinthya, additional, Gonzalez, Jose, additional, Makaretz, Sara J., additional, Siao Tick Chong, Michael, additional, Ramanan, Prianca, additional, Amaral, Ana C., additional, Normandin, Marc D., additional, Vanderburg, Charles R., additional, Gomperts, Stephen N., additional, Johnson, Keith A., additional, Frosch, Matthew P., additional, and Gómez-Isla, Teresa, additional

Published
2017
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9. Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders

Author

Perez, David L, primary, Matin, Nassim, additional, Barsky, Arthur, additional, Costumero-Ramos, Victor, additional, Makaretz, Sara J, additional, Young, Sigrid S, additional, Sepulcre, Jorge, additional, LaFranceJr, W Curt, additional, Keshavan, Matcheri S, additional, and Dickerson, Bradford C, additional

Published
2017
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10. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease

Author

Xia, Chenjie, primary, Makaretz, Sara J., additional, Caso, Christina, additional, McGinnis, Scott, additional, Gomperts, Stephen N., additional, Sepulcre, Jorge, additional, Gomez-Isla, Teresa, additional, Hyman, Bradley T., additional, Schultz, Aaron, additional, Vasdev, Neil, additional, Johnson, Keith A., additional, and Dickerson, Bradford C., additional

Published
2017
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11. Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases

Author

Gomperts, Stephen N., primary, Locascio, Joseph J., additional, Makaretz, Sara J., additional, Schultz, Aaron, additional, Caso, Christina, additional, Vasdev, Neil, additional, Sperling, Reisa, additional, Growdon, John H., additional, Dickerson, Bradford C., additional, and Johnson, Keith, additional

Published
2016
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12. Flortaucipir tau PET imaging in semantic variant primary progressive aphasia.

Author

Makaretz, Sara J., Quimby, Megan, Collins, Jessica, Makris, Nikos, McGinnis, Scott, Schultz, Aaron, Vasdev, Neil, Johnson, Keith A., and Dickerson, Bradford C.

Subjects
APHASIA, FRONTOTEMPORAL lobar degeneration, DNA-binding proteins, NEURONS, ALZHEIMER'S disease, POSITRON emission tomography, BRAIN metabolism, BRAIN, MAGNETIC resonance imaging, NERVE tissue proteins, NEURORADIOLOGY, PYRIDINE, RESEARCH funding
Abstract

Objective: The semantic variant of primary progressive aphasia (svPPA) is typically associated with frontotemporal lobar degeneration (FTLD) with longTAR DNA-binding protein (TDP)-43-positive neuropil threads and dystrophic neurites (type C), and is only rarely due to a primary tauopathy or Alzheimer's disease. We undertook this study to investigate the localisation and magnitude of the presumed tau Positron Emission Tomography (PET) tracer [18F]Flortaucipir (FTP; also known as T807 or AV1451) in patients with svPPA, hypothesising that most patients would not show tracer uptake different from controls.Methods: FTP and [11C]Pittsburgh compound B PET imaging as well as MRI were performed in seven patients with svPPA and in 20 controls. FTP signal was analysed by visual inspection and by quantitative comparison to controls, with and without partial volume correction.Results: All seven patients showed elevated FTP uptake in the anterior temporal lobe with a leftward asymmetry that was not observed in healthy controls. This elevated FTP signal, largely co-localised with atrophy, was evident on both visual inspection and quantitative cortical surface-based analysis. Five patients were amyloid negative, one was amyloid positive and one has an unknown amyloid status.Conclusions: In this series of patients with clinical profiles, structural MRI and amyloid PET imaging typical for svPPA, FTP signal was unexpectedly elevated with a spatial pattern localised to areas of atrophy. This raises questions about the possible off-target binding of this tracer to non-tau molecules associated with neurodegeneration. Further investigation with autopsy analysis will help illuminate the binding target(s) of FTP in cases of suspected FTLD-TDP neuropathology. [ABSTRACT FROM AUTHOR]

Published
2018
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