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1. Hepatitis C virus prevalence and level of intervention required to achieve the WHO targets for elimination in the European Union by 2030: a modelling study

Author

Razavi, Homie, Robbins, Sarah, Zeuzem, Stefan, Negro, Francesco, Buti, Maria, Duberg, Ann-Sofi, Roudot-Thoraval, Françoise, Craxi, Antonio, Manns, Michael, Marinho, Rui T, Hunyady, Bela, Colombo, Massimo, Aleman, Soo, Antonov, Krasimir, Arkkila, Perttu, Athanasakis, Kostas, Blach, Sarah, Blachier, Martin, Blasco, Antonio J, Calinas, Filipe, Calleja, Jose L, Christensen, Peer B, Cramp, Matthew E, Croes, Esther, de Knegt, Robert J, de Ledinghen, Victor, Delile, Jean-Michel, Estes, Chris, Falconer, Karolin, Färkkilä, Martti, Flisiak, Robert, Frankova, Sona, Gamkrelidze, Ivane, García-Samaniego, Javier, Genov, Jordan, Gerstoft, Jan, Gheorghe, Liana, Goldis, Adrian, Gountas, Ilias, Gregorčič, Sergeja, Gschwantler, Michael, Gunter, Jessie, Halota, Waldemar, Harcouet, Laura, Hézode, Christophe, Hoffmann, Patrick, Horvath, Gabor, Hrstic, Irena, Jarčuška, Peter, Jelev, Deian, Jeruma, Agita, Kåberg, Martin, Kieran, Jennifer, Kondili, Loreta A, Kotzev, Iskren, Krarup, Henrik, Kristian, Pavol, Lagging, Martin, Laleman, Wim, Lázaro, Pablo, Liakina, Valentina, Lukšić, Boris, Maimets, Matti, Makara, Mihály, Mateva, Lyudmila, Maticic, Mojca, Mennini, Francesco S, Mitova, Rumiana, Moreno, Christophe, Mossong, Joel, Murphy, Kimberly, Nde, Helen, Nemecek, Vratislav, Nonkovic, Dijana, Norris, Suzanne, Oltman, Marian, Øvrehus, Anne L H, Papatheodoridis, George, Pasini, Ken, Razavi-Shearer, Devin, Razavi-Shearer, Kathryn, Reesink, Henk W, Reic, Tatjana, Rozentale, Baiba, Ryder, Stephen D, Salupere, Riina, Sarmento-Castro, Rui, Sarrazin, Christoph, Schmelzer, Jonathan D, Schréter, Ivan, Seguin-Devaux, Carole, Simojoki, Kaarlo, Simonova, Marietta, Smit, Peter J, Souliotis, Kyriakos, Speiciene, Danute, Sperl, Jan, Stärkel, Peter, Struck, Daniel, Sypsa, Vana, Thornton, Lelia, Tolmane, Ieva, Tomasiewicz, Krzysztof, Valantinas, Jonas, Van Damme, Pierre, van de Vijver, David, van der Meer, Adriaan J, van Santen, Daniela, Van Vlierberghe, Hans, Vandijck, Dominique, Vella, Stefano, Videčnik-Zorman, Jerneja, Vogel, Wolfgang, Weis, Nina, and Hatzakis, Angelos

Published
2017
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2. Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study

Author

Blach, Sarah, Zeuzem, Stefan, Manns, Michael, Altraif, Ibrahim, Duberg, Ann-Sofi, Muljono, David H, Waked, Imam, Alavian, Seyed M, Lee, Mei-Hsuan, Negro, Francesco, Abaalkhail, Faisal, Abdou, Ahmed, Abdulla, Maheeba, Rached, Antoine Abou, Aho, Inka, Akarca, Ulus, Al Ghazzawi, Imad, Al Kaabi, Saad, Al Lawati, Faryal, Al Namaani, Khalid, Al Serkal, Youssif, Al-Busafi, Said A, Al-Dabal, Layla, Aleman, Soo, Alghamdi, Abdullah S, Aljumah, Abdulrahman A, Al-Romaihi, Hamad E, Andersson, Monique I, Arendt, Vic, Arkkila, Perttu, Assiri, Abdullah M, Baatarkhuu, Oidov, Bane, Abate, Ben-Ari, Ziv, Bergin, Colm, Bessone, Fernando, Bihl, Florian, Bizri, Abdul R, Blachier, Martin, Blasco, Antonio J, Mello, Carlos E Brandão, Bruggmann, Philip, Brunton, Cheryl R, Calinas, Filipe, Chan, Henry L Y, Chaudhry, Asad, Cheinquer, Hugo, Chen, Chien-Jen, Chien, Rong-Nan, Choi, Moon Seok, Christensen, Peer B, Chuang, Wan-Long, Chulanov, Vladimir, Cisneros, Laura, Clausen, Mette R, Cramp, Matthew E, Craxi, Antonio, Croes, Esther A, Dalgard, Olav, Daruich, Jorge R, de Ledinghen, Victor, Dore, Gregory J, El-Sayed, Manal H, Ergör, Gul, Esmat, Gamal, Estes, Chris, Falconer, Karolin, Farag, Elmoubashar, Ferraz, Maria L G, Ferreira, Paulo R, Flisiak, Robert, Frankova, Sona, Gamkrelidze, Ivane, Gane, Ed, García-Samaniego, Javier, Khan, Amir Ghafoor, Gountas, Ilias, Goldis, Adrian, Gottfredsson, Magnús, Grebely, Jason, Gschwantler, Michael, Pessôa, Mário Guimarães, Gunter, Jessie, Hajarizadeh, Behzad, Hajelssedig, Omer, Hamid, Saeed, Hamoudi, Waseem, Hatzakis, Angelos, Himatt, Sayed M, Hofer, Harald, Hrstic, Irena, Hui, Yee-Tak, Hunyady, Bela, Idilman, Ramazan, Jafri, Wasim, Jahis, Rohani, Janjua, Naveed Z, Jarčuška, Peter, Jeruma, Agita, Jonasson, Jón G, Kamel, Yasser, Kao, Jia-Horng, Kaymakoglu, Sabahattin, Kershenobich, David, Khamis, Jawad, Kim, Young S, Kondili, Loreta, Koutoubi, Zaher, Krajden, Mel, Krarup, Henrik, Lai, Moon-sing, Laleman, Wim, Lao, Wai-cheung, Lavanchy, Daniel, Lázaro, Pablo, Leleu, Henri, Lesi, Olufunmilayo, Lesmana, Laurentius A, Li, Michael, Liakina, Valentina, Lim, Young-Suk, Luksic, Boris, Mahomed, Adam, Maimets, Matti, Makara, Mihály, Malu, Abraham O, Marinho, Rui T, Marotta, Paul, Mauss, Stefan, Memon, Muhammad S, Correa, Maria C Mendes, Mendez-Sanchez, Nahum, Merat, Shahin, Metwally, Ammal M, Mohamed, Rosmawati, Moreno, Christophe, Mourad, Fadi H, Müllhaupt, Beat, Murphy, Kimberly, Nde, Helen, Njouom, Richard, Nonkovic, Diana, Norris, Suzanne, Obekpa, Solomon, Oguche, Stephen, Olafsson, Sigurður, Oltman, Marian, Omede, Ogu, Omuemu, Casimir, Opare-Sem, Ohene, Øvrehus, Anne L H, Owusu-Ofori, Shirley, Oyunsuren, Tsendsuren S, Papatheodoridis, George, Pasini, Ken, Peltekian, Kevork M, Phillips, Richard O, Pimenov, Nikolay, Poustchi, Hossein, Prabdial-Sing, Nishi, Qureshi, Huma, Ramji, Alnoor, Razavi-Shearer, Devin, Razavi-Shearer, Kathryn, Redae, Berhane, Reesink, Henk W, Ridruejo, Ezequiel, Robbins, Sarah, Roberts, Lewis R, Roberts, Stuart K, Rosenberg, William M, Roudot-Thoraval, Françoise, Ryder, Stephen D, Safadi, Rifaat, Sagalova, Olga, Salupere, Riina, Sanai, Faisal M, Avila, Juan F Sanchez, Saraswat, Vivek, Sarmento-Castro, Rui, Sarrazin, Christoph, Schmelzer, Jonathan D, Schréter, Ivan, Seguin-Devaux, Carole, Shah, Samir R, Sharara, Ala I, Sharma, Manik, Shevaldin, Anatoly, Shiha, Gamal E, Sievert, William, Sonderup, Mark, Souliotis, Kyriakos, Speiciene, Danute, Sperl, Jan, Stärkel, Peter, Stauber, Rudolf E, Stedman, Catherine, Struck, Daniel, Su, Tung-Hung, Sypsa, Vana, Tan, Soek-Siam, Tanaka, Junko, Thompson, Alexander J, Tolmane, Ieva, Tomasiewicz, Krzysztof, Valantinas, Jonas, Van Damme, Pierre, van der Meer, Adriaan J, van Thiel, Ingo, Van Vlierberghe, Hans, Vince, Adriana, Vogel, Wolfgang, Wedemeyer, Heiner, Weis, Nina, Wong, Vincent WS, Yaghi, Cesar, Yosry, Ayman, Yuen, Man-fung, Yunihastuti, Evy, Yusuf, Aasim, Zuckerman, Eli, and Razavi, Homie

Published
2017
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3. Daclatasvir plus simeprevir with or without ribavirin for the treatment of chronic hepatitis C virus genotype 1 infection

Author

Zeuzem, Stefan, Hézode, Christophe, Bronowicki, Jean-Pierre, Loustaud-Ratti, Veronique, Gea, Francisco, Buti, Maria, Olveira, Antonio, Banyai, Tivadar, Al-Assi, M. Tarek, Petersen, Joerg, Thabut, Dominique, Gadano, Adrian, Pruitt, Ronald, Makara, Mihály, Bourlière, Marc, Pol, Stanislas, Beumont-Mauviel, Maria, Ouwerkerk-Mahadevan, Sivi, Picchio, Gaston, Bifano, Marc, M<ce:sup loc='post">c</ce:sup>Phee, Fiona, Boparai, Navdeep, Cheung, Kin, Hughes, Eric A., and Noviello, Stephanie

Published
2016
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5. A hepatitis C-vírus szűrésének és kezelésének 10 éves tapasztalata a börtönökben

Author

Werling, Klára, primary, Makara, Mihály, additional, Nemesi, Krisztina, additional, Horváth, Gábor, additional, Schneider, Ferenc, additional, Bali, Ildikó, additional, Enyedi, Judit, additional, Jancsik, Viktor, additional, Káfony, András, additional, Lesch, Miklós, additional, Lombay, Béla, additional, Müller, Zsófia, additional, Ozsvár, Zsófia, additional, Patai, Árpád, additional, Péterfi, Zoltán, additional, Pusztay, Margit, additional, Szabó, Olga, additional, Szlávik, János, additional, Tóth, Tamás, additional, Varga, Márta, additional, Gács, Judit, additional, Újhelyi, Eszter, additional, and Nemes Nagy, Anna, additional

Published
2022
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7. Hepatitis C Screening and Treatment Program in Hungarian Prisons in the Era of Direct Acting Antiviral Agents

Author

Werling, Klára, primary, Hunyady, Béla, additional, Makara, Mihály, additional, Nemesi, Krisztina, additional, Horváth, Gábor, additional, Enyedi, Ferenc Schneider Judit, additional, Müller, Zsófia, additional, Lesch, Miklós, additional, Péterfi, Zoltán, additional, Tóth, Tamás, additional, Gács, Judit, additional, Fehér, Zsuzsanna, additional, Ujhelyi, Eszter, additional, Molnár, Emese, additional, and Nagy, Anna Nemes, additional

Published
2022
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8. Practice Guidelines of the Central European Hepatologic Collaboration (CEHC) on the Use of Thrombopoietin Receptor Agonists in Patients with Chronic Liver Disease Undergoing Invasive Procedures

Author

Flisiak, Robert, primary, Antonov, Krasimir, additional, Drastich, Pavel, additional, Jarcuska, Peter, additional, Maevskaya, Marina, additional, Makara, Mihály, additional, Puljiz, Željko, additional, Štabuc, Borut, additional, and Trifan, Anca, additional

Published
2021
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9. A hepatitis C-vírus-fertőzés szűrése, diagnosztikája, antivirális terápiája, kezelés utáni gondozása : Magyar konszenzusajánlás

Author

Hunyady, Béla, primary, Gerlei, Zsuzsanna, additional, Gervain, Judit, additional, Horváth, Gábor, additional, Kiss, András, additional, Lengyel, Gabriella, additional, Pár, Alajos, additional, Pár, Gabriella, additional, Péter, Zoltán, additional, Rókusz, László, additional, Schneider, Ferenc, additional, Schuller, János, additional, Szalay, Ferenc, additional, Tornai, István, additional, Werling, Klára, additional, and Makara, Mihály, additional

Published
2021
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10. A hepatitis C-vírus-fertőzés szűrése, diagnosztikája, antivirális terápiája, kezelés utáni gondozása. Magyar konszenzusajánlás. Érvényes: 2017. szeptember 22-től

Author

Alajos Pár, Gerlei Zsuzsanna, Gabriella Lengyel, Werling Klára, Schneider Ferenc, Béla Hunyady, Ferenc Szalay, Rókusz László, Péter Zoltán, Horváth Gábor, Tornai István, Gervain Judit, and Makara Mihály

Subjects
business.industry, Hepatitis C virus, General Medicine, medicine.disease, medicine.disease_cause, Virology, Interferon, Hepatocellular carcinoma, Genotype, medicine, Protease inhibitor (pharmacology), Polymerase inhibitor, Viral hepatitis, business, medicine.drug
Abstract

The treatment of hepatitis C is based on a national consensus guideline updated six-monthly according to local availability and affordability of approved therapies through a transparent allocation system in Hungary. This updated guideline incorporates some special new aspects, including recommendations for screening, diagnostics, use and allocation of novel direct acting antiviral agents. The indication of therapy in patients with no contraindication is based on the demonstration of viral replication with consequent inflammation and/or fibrosis in the liver. Non-invasive methods (elastographies and biochemical methods) are preferred for liver fibrosis staging. The budget allocated for these patients is limited. Interferon-based or interferon-free therapies are available for the treatment. Due to their limited success rate as well as to their (sometimes severe) side-effects, the mandatory use of interferon-based therapies as first line treatment can not be accepted from the professional point of view. However, they can be used as optional therapy in treatment-naïve patients with mild disease. As of interferon-free therapies, priority is given to those with urgent need based on a pre-defined scoring system reflecting mainly the stage of the liver disease, but considering also additional factors, i.e., hepatic decompensation, other complications, activity and progression of liver disease, risk of transmission and other special issues. Approved treatments are restricted to the most cost-effective combinations based on the cost per sustained virological response value in different patient categories with consensus amongst treating physicians, the National Health Insurance Fund of Hungary and patients’ organizations. Interferon-free treatments and shorter therapy durations are preferred. Orv Hetil. 2018; 159(Suppl 1): 3–23.

Published
2018
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11. Restrictions for reimbursement of interferon-free direct-acting antiviral drugs for HCV infection in Europe

Author

Marshall, Alison D., Cunningham, Evan B., Nielsen, Stine, Aghemo, Alessio, Alho, Hannu, Backmund, Markus, Bruggmann, Philip, Dalgard, Olav, Seguin-Devaux, Carole, Flisiak, Robert, Foster, Graham R., Gheorghe, Liana, Goldberg, David, Goulis, Ioannis, Hickman, Matthew, Hoffmann, Patrick, Jancorienė, Ligita, Jarcuska, Peter, Kåberg, Martin, Kostrikis, Leondios G., Makara, Mihály, Maimets, Matti, Marinho, Rui Tato, Matičič, Mojca, Norris, Suzanne, Ólafsson, Sigurður, Øvrehus, Anne, Pawlotsky, Jean-Michel, Pocock, James, Robaeys, Geert, Roncero, Carlos, Simonova, Marieta, Sperl, Jan, Tait, Michele, Tolmane, Ieva, Tomaselli, Stefan, van der Valk, Marc, Vince, Adriana, Dore, Gregory J., Lazarus, Jeffrey V., Grebely, Jason, International Network on Hepatitis in Substance Users (INHSU), Kostrikis, Leondios G. [0000-0002-5340-7109], Infectious diseases, AII - Infectious diseases, AII - Amsterdam institute for Infection and Immunity, APH - Digital Health, APH - Personalized Medicine, and APH - Global Health

Subjects
hepatitis C virus, HIV Infections, chemistry.chemical_compound, 0302 clinical medicine, Antiviral Agents/economics, HIV-HCV co-infection, 030212 general & internal medicine, Reimbursement, liver fibrosis, media_common, Dasabuvir, Coinfection, Health Policy, Gastroenterology, Hepatitis C, 3. Good health, Europe, Hepatitis C, Chronic/complications, Insurance, Health, Reimbursement, 030211 gastroenterology & hepatology, Switzerland, medicine.drug, medicine.medical_specialty, HIV Infections/complications, Antiviral Agents, Drug Costs, 03 medical and health sciences, hepatitis C treatment, medicine, Humans, media_common.cataloged_instance, European Union, European union, PWID, Intensive care medicine, Hepatitis, direct-acting antiviral, Hepatology, business.industry, Hepatitis C, Chronic, alcohol use, medicine.disease, reimbursement, Virology, Ombitasvir, chemistry, Paritaprevir, Ritonavir, business, treatment restrictions
Abstract

All-oral direct-acting antiviral drugs (DAAs) for hepatitis C virus, which have response rates of 95% or more, represent a major clinical advance. However, the high list price of DAAs has led many governments to restrict their reimbursement. We reviewed the availability of, and national criteria for, interferon-free DAA reimbursement among countries in the European Union and European Economic Area, and Switzerland. Reimbursement documentation was reviewed between Nov 18, 2016, and Aug 1, 2017. Primary outcomes were fibrosis stage, drug or alcohol use, prescriber type, and HIV co-infection restrictions. Among the 35 European countries and jurisdictions included, the most commonly reimbursed DAA was ombitasvir, paritaprevir, and ritonavir, with dasabuvir, and with or without ribavirin (33 [94%] countries and jurisdictions). 16 (46%) countries and jurisdictions required patients to have fibrosis at stage F2 or higher, 29 (83%) had no listed restrictions based on drug or alcohol use, 33 (94%) required a specialist prescriber, and 34 (97%) had no additional restrictions for people co-infected with HIV and hepatitis C virus. These findings have implications for meeting WHO targets, with evidence of some countries not following the 2016 hepatitis C virus treatment guidelines by the European Association for the Study of Liver. 3 2 125 133

Published
2018
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13. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

Author

Younossi, Zobair M, primary, Ratziu, Vlad, additional, Loomba, Rohit, additional, Rinella, Mary, additional, Anstee, Quentin M, additional, Goodman, Zachary, additional, Bedossa, Pierre, additional, Geier, Andreas, additional, Beckebaum, Susanne, additional, Newsome, Philip N, additional, Sheridan, David, additional, Sheikh, Muhammad Y, additional, Trotter, James, additional, Knapple, Whitfield, additional, Lawitz, Eric, additional, Abdelmalek, Manal F, additional, Kowdley, Kris V, additional, Montano-Loza, Aldo J, additional, Boursier, Jerome, additional, Mathurin, Philippe, additional, Bugianesi, Elisabetta, additional, Mazzella, Giuseppe, additional, Olveira, Antonio, additional, Cortez-Pinto, Helena, additional, Graupera, Isabel, additional, Orr, David, additional, Gluud, Lise Lotte, additional, Dufour, Jean-Francois, additional, Shapiro, David, additional, Campagna, Jason, additional, Zaru, Luna, additional, MacConell, Leigh, additional, Shringarpure, Reshma, additional, Harrison, Stephen, additional, Sanyal, Arun J, additional, Abdelmalek, Manal, additional, Abrams, Gary, additional, Aguilar, Humberto, additional, Ahmed, Aijaz, additional, Aigner, Elmar, additional, Aithal, Guruprasad, additional, Ala, Aftab, additional, Alazawi, William, additional, Albillos, Agustin, additional, Allison, Michael, additional, Al-Shamma, Sfa, additional, Andrade, Raul, additional, Andreone, Pietro, additional, Angelico, Mario, additional, Ankoma-Sey, Victor, additional, Anstee, Quentin, additional, Anty, Rodolphe, additional, Araya, Victor, additional, Arenas Ruiz, Juan Ignacio, additional, Arkkila, Perttu, additional, Arora, Marty, additional, Asselah, Tarik, additional, Au, Jennifer, additional, Ayonrinde, Oyekoya, additional, Bailey, Robert James, additional, Balakrishnan, Maya, additional, Bambha, Kiran, additional, Bansal, Meena, additional, Barritt, Sidney, additional, Bate, John, additional, Beato, Jorge, additional, Behari, Jaideep, additional, Bellot, Pablo, additional, Ben Ari, Ziv, additional, Bennett, Michael, additional, Berenguer, Marina, additional, Beretta-Piccoli, Benedetta Terziroli, additional, Berg, Thomas, additional, Bonacini, Maurizio, additional, Bonet, Lucia, additional, Borg, Brian, additional, Bourliere, Marc, additional, Bowman, William, additional, Bradley, David, additional, Brankovic, Marija, additional, Braun, Marius, additional, Bronowicki, Jean-Pierre, additional, Bruno, Savino, additional, Cai, Cindy, additional, Calderon, Amy, additional, Calleja Panero, José Luis, additional, Carey, Elizabeth, additional, Carmiel, Michal, additional, Carrión, Jose Antonio, additional, Cave, Matthew, additional, Chagas, Cristina, additional, Chami, Tawfik, additional, Chang, Alan, additional, Coates, Allan, additional, Cobbold, Jeremy, additional, Costentin, Charlote, additional, Corey, Kathleen, additional, Corless, Lynsey, additional, Crespo, Javier, additional, Cruz Pereira, Oscar, additional, de Ledinghen, Victor, additional, deLemos, Andrew, additional, Diago, Moises, additional, Dong, Mamie, additional, Dufour, Jean-François, additional, Dugalic, Predrag, additional, Dunn, Winston, additional, Elkhashab, Magby, additional, Epstein, Michael, additional, Escudero-Garcia, Maria Desamparados, additional, Etzion, Ohad, additional, Evans, Larry, additional, Falcone, Robert, additional, Fernandez, Conrado, additional, Ferreira, Jose, additional, Fink, Scott, additional, Finnegan, Kevin, additional, Firpi-Morell, Roberto, additional, Floreani, Annarosa, additional, Fontanges, Thierry, additional, Ford, Ryan, additional, Forrest, Ewan, additional, Fowell, Andrew, additional, Fracanzani, Anna Ludovica, additional, Francque, Sven, additional, Freilich, Bradley, additional, Frias, Juan, additional, Fuchs, Michael, additional, Fuentes, Javier, additional, Galambos, Michael, additional, Gallegos, Juan, additional, Geerts, Anja, additional, George, Jacob, additional, Ghali, Maged, additional, Ghalib, Reem, additional, Gholam, Pierre, additional, Gines, Pere, additional, Gitlin, Norman, additional, Goeser, Tobias, additional, Goff, John, additional, Gordon, Stuart, additional, Gordon, Frederic, additional, Goria, Odile, additional, Greer, Shaun, additional, Grigorian, Alla, additional, Gronbaek, Henning, additional, Guillaume, Maeva, additional, Gunaratnam, Naresh, additional, Halegoua-De Marzio, Dina, additional, Hameed, Bilal, additional, Hametner, Stephanie, additional, Hamilton, James, additional, Hartleb, Marek, additional, Hassanein, Tarek, additional, Häussinger, Dieter, additional, Hellstern, Paul, additional, Herring, Robert, additional, Heurich, Eva, additional, Hezode, Christophe, additional, Hinrichsen, Holger, additional, Holland Fischer, Peter, additional, Horsmans, Yves, additional, Huang, Jonathan, additional, Hussaini, Hyder, additional, Jakiche, Antoine, additional, Jeffers, Lennox, additional, Jones, Blake, additional, Jorge, Rosa, additional, Jorquera, Francisco, additional, Joshi, Shoba, additional, Kahraman, Alisan, additional, Kaita, Kelly, additional, Karyotakis, Nicholas, additional, Kayali, Zeid, additional, Kechagias, Stergios, additional, Kepczyk, Thomas, additional, Khalili, Mandana, additional, Khallafi, Hicham, additional, Kluwe, Johannes, additional, Kohli, Anita, additional, Korenblat, Kevin, additional, Kowdley, Kris, additional, Krag, Aleksander, additional, Krause, Richard, additional, Kremer, Andreas, additional, Krok, Karen, additional, Krstic, Miodrag, additional, Kugelmas, Marcelo, additional, Kumar, Sonal, additional, Kuwada, Scott, additional, Labarriere, Damien, additional, Lai, Michelle, additional, Laleman, Wim, additional, Lampertico, Pietro, additional, Lee, Alice, additional, Leroy, Vincent, additional, Lidofsky, Steven, additional, Lim, Tina Huey, additional, Lim, Joseph, additional, Lipkis, Donald, additional, Little, Ester, additional, Lonardo, Amadeo, additional, Long, Michelle, additional, Luketic, Velimir Anthony Christopher, additional, Lurie, Yoav, additional, Macedo, Guilherme, additional, Magalhaes, Joana, additional, Makara, Mihály, additional, Maliakkal, Benedict, additional, Manns, Michael, additional, Manousou, Pinelopi, additional, Mantry, Parvez, additional, Marchesini, Giulio, additional, Marinho, Carla, additional, Marotta, Paul, additional, Marschall, Hanns-Ulrich, additional, Martinez, Linda, additional, Mayo, Marlyn, additional, McCullen, Mark, additional, McLaughlin, William, additional, Merle, Uta, additional, Merriman, Raphael, additional, Modi, Apurva, additional, Molina, Esther, additional, Montano-Loza, Aldo, additional, Monteverde, Carlos, additional, Morales Cardona, Amilcar, additional, Moreea, Sulleman, additional, Moreno, Christophe, additional, Morisco, Filomena, additional, Mubarak, Abdullah, additional, Muellhaupt, Beat, additional, Mukherjee, Sandeep, additional, Müller, Tobias, additional, Nagorni, Aleksandar, additional, Naik, Jahnavi, additional, Neff, Guy, additional, Nevah, Moises, additional, Newsome, Philip, additional, Nguyen-Khac, Eric, additional, Noureddin, Mazen, additional, Oben, Jude, additional, Orlent, Hans, additional, Orr, James, additional, Ortiz-Lasanta, Grisell, additional, Ozenne, Violaine, additional, Pandya, Prashant, additional, Paredes, Angelo, additional, Park, James, additional, Patel, Joykumar, additional, Patel, Keyur, additional, Paul, Sonali, additional, Patton, Heather, additional, Peck-Radosavljevic, Markus, additional, Petta, Salvatore, additional, Pianko, Stephen, additional, Piekarska, Anna, additional, Pimstone, Neville, additional, Pisegna, Joseph, additional, Pockros, Paul, additional, Pol, Stanislas, additional, Porayko, Michael, additional, Poulos, John, additional, Pound, David, additional, Pouzar, Joe, additional, Presa Ramos, Jose, additional, Pyrsopoulos, Nikolaos, additional, Rafiq, Nila, additional, Muller, Kate, additional, Ramji, Alnoor, additional, Ravinuthala, Ravi, additional, Reddy, Chakradhar, additional, Reddy K G, Gautham, additional, Reddy K R, K. Rajender, additional, Regenstein, Frederic, additional, Reindollar, Robert, additional, Reynolds, Justin, additional, Riera, Andres, additional, Rivera Acosta, Jose, additional, Robaeys, Geert, additional, Roberts, Stuart, additional, Rodriguez-Perez, Federico, additional, Romero, Sandor, additional, Romero-Gomez, Manuel, additional, Rubin, Raymond, additional, Rumi, Mariagrazia, additional, Rushbrook, Simon, additional, Rust, Christian, additional, Ryan, Michael, additional, Safadi, Rifaat, additional, Said, Adnan, additional, Salminen, Kimmo, additional, Samuel, Didier, additional, Santoro, John, additional, Sanyal, Arun, additional, Sarkar, Souvik, additional, Schaeffer, Cynthia, additional, Schattenberg, Jörn, additional, Schiefke, Ingolf, additional, Schiff, Eugene, additional, Schmidt, Wolfgang, additional, Schneider, Jeffrey, additional, Schouten, Jeoffrey, additional, Schultz, Michael, additional, Sebastiani, Giada, additional, Semela, David, additional, Sepe, Thomas, additional, Sheikh, Aasim, additional, Sheikh, Muhammad, additional, Sherman, Kenneth, additional, Shibolet, Oren, additional, Shiffman, Mitchell, additional, Siddique, Asma, additional, Sieberhagen, Cyril, additional, Sigal, Samuel, additional, Sikorska, Katarzyna, additional, Simon, Krzysztof, additional, Sinclair, Marie, additional, Skoien, Richard, additional, Solis, Joel, additional, Sood, Siddharth, additional, Souder, Bob, additional, Spivey, James, additional, Stal, Per, additional, Stinton, Laura, additional, Strasser, Simone, additional, Svorcan, Petar, additional, Szabo, Gyongzi, additional, Talal, Andrew, additional, Tam, Edward, additional, Tetri, Brent, additional, Thuluvath, Paul, additional, Tobias, Hillel, additional, Tomasiewicz, Krzysztof, additional, Torres, Dawn, additional, Tran, Albert, additional, Trauner, Michael, additional, Trautwein, Christian, additional, Tsochatzis, Emanuel, additional, Unitt, Esther, additional, Vargas, Victor, additional, Varkonyi, Istvan, additional, Veitsman, Ella, additional, Vespasiani Gentilucci, Umberto, additional, Victor, David, additional, Vierling, John, additional, Vincent, Catherine, additional, Vincze, Aron, additional, von der Ohe, Manfred, additional, Von Roenn, Natasha, additional, Vuppalanchi, Raj, additional, Waters, Michael, additional, Watt, Kymberly, additional, Wattacheril, Julia, additional, Weltman, Martin, additional, Wieland, Amanda, additional, Wiener, Gregory, additional, Williams A, Alonzo, additional, Williams J, Jeffrey, additional, Wilson, Jason, additional, Yataco, Maria, additional, Yoshida, Eric, additional, Younes, Ziad, additional, Yuan, Liyun, additional, Zivony, Adam, additional, Zogg, Donald, additional, Zoller, Heinz, additional, Zoulim, Fabien, additional, Zuckerman, Eli, additional, and Zuin, Massimo, additional

Published
2019
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19. Protocol for the antiviral treatment of hepatitis C

Author

Makara Mihály, Szalay Ferenc, Pár Alajos, Telegdy László, Tornai István, Infektológiai Szakmai Kollégium, Hunyady Béla, Horváth Gábor, Gasztroenterológiai Szakmai Kollégium, and Gervain Judit

Subjects
business.industry, Antiviral therapy, Medicine, General Medicine, Hepatitis C, business, medicine.disease, Virology
Published
2010
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20. A hepatitis C-vírus-fertőzés szűrése, diagnosztikája, antivirális terápiája, kezelés utáni gondozása. Magyar konszenzusajánlás. Érvényes: 2017. szeptember 22-től

Author

Hunyady, Béla, primary, Gerlei, Zsuzsanna, additional, Gervain, Judit, additional, Horváth, Gábor, additional, Lengyel, Gabriella, additional, Pár, Alajos, additional, Péter, Zoltán, additional, Rókusz, László, additional, Schneider, Ferenc, additional, Szalay, Ferenc, additional, Tornai, István, additional, Werling, Klára, additional, and Makara, Mihály, additional

Published
2018
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21. A hepatitis B- és D-vírus-fertőzés diagnosztikája, antivirális kezelése. Magyar konszenzusajánlás. Érvényes: 2017. szeptember 22-től

Author

Horváth, Gábor, primary, Gerlei, Zsuzsanna, additional, Gervain, Judit, additional, Lengyel, Gabriella, additional, Makara, Mihály, additional, Pár, Alajos, additional, Rókusz, László, additional, Szalay, Ferenc, additional, Tornai, István, additional, Werling, Klára, additional, and Hunyady, Béla, additional

Published
2018
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22. Ombitasvir/paritaprevir/ritonavir + dasabuvir + ribavirin in HCV genotype 1 infected patients who failed previous protease inhibitor therapy

Author

Hunyady, Béla, primary, Abonyi, Margit, additional, Gerlei, Zsuzsanna, additional, Gervain, Judit, additional, Horváth, Gábor, additional, Jancsik, Viktor, additional, Lengyel, Gabriella, additional, Makkai, Erzsébet, additional, Pár, Alajos, additional, Péter, Zoltán, additional, Pusztay, Margit, additional, Ribiczey, Pál, additional, Rókusz, László, additional, Sarrazin, Christoph, additional, Schneider, Ferenc, additional, Susser, Simone, additional, Szalay, Ferenc, additional, Tornai, István, additional, Tusnádi, Anna, additional, Újhelyi, Eszter, additional, Werling, Klára, additional, and Makara, Mihály, additional

Published
2018
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23. NEUROCOGNITIVE FUNCTIONS IN PATIENTS WITH HEPATITIS C INFECTION.

Author

HORVÁTH, Gergely, KELETI, Teodóra, MAKARA, Mihály, UNGVARI, Gabor S., and GAZDAG, Gábor

Subjects
EXECUTIVE function, BECK Depression Inventory, QUALITY of work life, JOB performance, SHORT-term memory
Abstract

Copyright of Clinical Neuroscience / Ideggyógyászati Szemle is the property of LifeTime Media Kft. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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25. A hepatitis C-vírus-fertőzés szűrése, diagnosztikája, antivirális terápiája, kezelés utáni gondozása. Magyar konszenzusajánlás. Érvényes: 2016. október 15-től

Author

Hunyady, Béla, primary, Gerlei, Zsuzsanna, additional, Gervain, Judit, additional, Horváth, Gábor, additional, Lengyel, Gabriella, additional, Pár, Alajos, additional, Péter, Zoltán, additional, Rókusz, László, additional, Schneider, Ferenc, additional, Szalay, Ferenc, additional, Tornai, István, additional, Werling, Klára, additional, and Makara, Mihály, additional

Published
2017
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26. A hepatitis B- és D-vírus-fertőzés diagnosztikája, antivirális kezelése. Magyar konszenzusajánlás. Érvényes: 2016. október 15-től

Author

Horváth, Gábor, primary, Gerlei, Zsuzsanna, additional, Gervain, Judit, additional, Lengyel, Gabriella, additional, Makara, Mihály, additional, Pár, Alajos, additional, Rókusz, László, additional, Szalay, Ferenc, additional, Tornai, István, additional, Werling, Klára, additional, and Hunyady, Béla, additional

Published
2017
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28. Bocepreviralapú hármas kezelés hatékonyságának és biztonságosságának retrospektív elemzése előrehaladott fibrosisstádiumú, hepatitis C-vírus 1-es genotípussal fertőzött, korábban sikertelenül kezelt magyar betegeknél

Author

Hunyady, Béla, primary, Abonyi, Margit, additional, Csefkó, Klára, additional, Gervain, Judit, additional, Haragh, Attila, additional, Horváth, Gábor, additional, Jancsik, Viktor, additional, Makkai, Erzsébet, additional, Müller, Zsófia, additional, Ribiczey, Pál, additional, Sipos, Béla, additional, Szabó, Olga, additional, Szalay, Ferenc, additional, Szentgyörgyi, László, additional, Tornai, István, additional, Újhelyi, Eszter, additional, Varga, Márta, additional, Weisz, György, additional, and Makara, Mihály, additional

Published
2016
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30. Előrehaladott májbetegséggel járó krónikus C-vírus-hepatitises betegek kezelésével nyert tapasztalataink a telaprevir Korai Hozzáférési Program keretében: interim analízis

Author

Tornai, István, Bányai, Tivadar, Gervain, Judit, Horváth, Gábor, Makara, Mihály, Martyin, Tibor, Nemes, Zsuzsanna, Pár, Alajos, Pár, Gabriella, Péterfi, Zoltán, Szalay, Ferenc, Szinku, Zsolt, Tóth, Tamás, Vincze, Áron, Lonjon-Domanec, Isabelle, Demasi, Ralph, and Hunyady, Béla

Subjects
Orvostudományok, Klinikai orvostudományok
Abstract

LB

Published
2014

34. Hepatitis C-vírus-fertőzés: diagnosztika, antivirális terápia, kezelés utáni gondozás. Magyar konszenzusajánlás. Érvényes: 2015. szeptember 12-től

Author

Hunyady, Béla, primary, Gerlei, Zsuzsanna, additional, Gervain, Judit, additional, Horváth, Gábor, additional, Lengyel, Gabriella, additional, Pár, Alajos, additional, Péter, Zoltán, additional, Rókusz, László, additional, Schneider, Ferenc, additional, Szalay, Ferenc, additional, Tornai, István, additional, Werling, Klára, additional, and Makara, Mihály, additional

Published
2015
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35. A hepatitis B- és D-vírus-fertőzés diagnosztikája, antivirális kezelése. Magyar konszenzusajánlás. Érvényes: 2015. szeptember 12-től

Author

Horváth, Gábor, primary, Gerlei, Zsuzsanna, additional, Gervain, Judit, additional, Lengyel, Gabriella, additional, Makara, Mihály, additional, Pár, Alajos, additional, Rókusz, László, additional, Szalay, Ferenc, additional, Tornai, István, additional, Werling, Klára, additional, and Hunyady, Béla, additional

Published
2015
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41. Diagnosis, treatment, and follow-up of hepatitis C virus related liver disease.National consensus guideline in Hungary

Author

Hunyady, Béla, primary, Gerlei, Zsuzsanna, additional, Gervain, Judit, additional, Horváth, Gábor, additional, Lengyel, Gabriella, additional, Pár, Alajos, additional, Rókusz, László, additional, Szalay, Ferenc, additional, †Telegdy, László, additional, Tornai, István, additional, Werling, Klára, additional, and Makara, Mihály, additional

Published
2015
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42. Diagnosis, treatment, and follow-up of hepatitis C virus related liver disease.Hungarian national consensus guideline

Author

Hunyady, Béla, primary, Gerlei, Zsuzsanna, additional, Gervain, Judit, additional, Horváth, Gábor, additional, Lengyel, Gabriella, additional, Pár, Alajos, additional, Rókusz, László, additional, Szalay, Ferenc, additional, †Telegdy, László, additional, Tornai, István, additional, Werling, Klára, additional, and Makara, Mihály, additional

Published
2015
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43. Diagnosis and treatment of chronic hepatitis B and D.Hungarian national consensus guideline

Author

Horváth, Gábor, primary, Gerlei, Zsuzsanna, additional, Gervain, Judit, additional, Lengyel, Gabriella, additional, Makara, Mihály, additional, Pár, Alajos, additional, Rókusz, László, additional, Szalay, Ferenc, additional, †Telegdy, László, additional, Tornai, István, additional, Werling, Klára, additional, and Hunyady, Béla, additional

Published
2015
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44. [Protocol for the antiviral therapy of hepatitis C]

Author

Gervain, Judit, Horváth, Gábor, Hunyady, Béla, Makara, Mihály, Pár, Alajos, Szalay, Ferenc, Tornai, István, and Telegdy, László

Subjects
Liver, Ribavirin, Humans, Interferon-alpha, HIV Infections, Interferons, Interferon alpha-2, Antiviral Agents, Hepatitis C, Polymerase Chain Reaction, Algorithms, Recombinant Proteins, Polyethylene Glycols
Published
2010

46. Performance of two HCV RNA assays during protease inhibitor-based triple therapy in patients with advanced liver fibrosis and cirrhosis

Author

Maasoumy, Benjamin, Hunyady, Bela, Calvaruso, Vincenza, Makara, Mihály, Vermehren, Johannes, Haragh, Attila, Susser, Simone, Bremer, Birgit, Cloherty, Gavin, Manns, Michael P., Craxì, Antonio, Wedemeyer, Heiner, Sarrazin, Christoph, Maasoumy, Benjamin, Hunyady, Bela, Calvaruso, Vincenza, Makara, Mihály, Vermehren, Johannes, Haragh, Attila, Susser, Simone, Bremer, Birgit, Cloherty, Gavin, Manns, Michael P., Craxì, Antonio, Wedemeyer, Heiner, and Sarrazin, Christoph

Abstract

Introduction: On-treatment HCV RNA measurements are crucial for the prediction of a sustained virological response (SVR) and to determine treatment futility during protease inhibitor-based triple therapies. In patients with advanced liver disease an accurate risk/benefit calculation based on reliable HCV RNA results can reduce the number of adverse events. However, the different available HCV RNA assays vary in their diagnostic performance. Aim: To investigate the clinical relevance of concordant and discordant results of two HCV RNA assays during triple therapy with boceprevir and telaprevir in patients with advanced liver fibrosis/cirrhosis. Methods: We collected on-treatment samples of 191 patients with advanced liver fibrosis/cirrhosis treated at four European centers for testing with the Abbott RealTime (ART) and COBAS AmpliPrep/COBAS TaqMan HCV v2.0 (CTM) assays. Results: Discordant test results for HCV RNA detectability were observed in 23% at week 4, 17% at week 8/12 and 9% at week 24 on-treatment. The ART detected HCV RNA in 41% of week 4 samples tested negative by the CTM. However, the positive predictive value of an undetectable week 4 result for SVR was similar for both assays (80% and 82%). Discordance was also found for application of stopping rules. In 27% of patients who met stopping rules by CTM the ART measured levels below the respective cut-offs of 100 and 1000 IU/ml, respectively, which would have resulted in treatment continuation. In contrast, in nine patients with negative HCV RNA by CTM at week 24 treatment would have been discontinued due to detectable residual HCV RNA by the ART assay. Importantly, only 4 of these patients failed to achieve SVR. Conclusion: Application of stopping rules determined in approval studies by one assay to other HCV RNA assays in clinical practice may lead to over and undertreatment in a significant number of patients undergoing protease inhibitor-based triple therapy.

Published
2014

47. Performance of Two HCV RNA Assays during Protease Inhibitor-Based Triple Therapy in Patients with Advanced Liver Fibrosis and Cirrhosis

Author

Maasoumy, Benjamin, primary, Hunyady, Bela, additional, Calvaruso, Vincenza, additional, Makara, Mihály, additional, Vermehren, Johannes, additional, Haragh, Attila, additional, Susser, Simone, additional, Bremer, Birgit, additional, Cloherty, Gavin, additional, Manns, Michael P., additional, Craxì, Antonio, additional, Wedemeyer, Heiner, additional, and Sarrazin, Christoph, additional

Published
2014
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49. Sustained Virologic Response 12 Weeks Post-Treatment With ABT-450/Ritonavir/Ombitasvir and Dasabuvir With Ribavirin (SAPPHIRE I and II) is Independent of Patient Subgroups

Author

Brunetto, Maurizia Rossana, primary, Makara, Mihály, additional, Hinrichsen, Holger, additional, Hanson, John, additional, Bennett, Michael, additional, Lawitz, Eric, additional, Xiong, Junyuan, additional, Coakley, Eoin, additional, Baykal, Tolga, additional, and Neff, Guy, additional

Published
2014
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