1. Pembrolizumab reactivates pulmonary granulomatosis
- Author
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Majdi Al-dliw, Mohammed Megri, Ibrahim Shahoub, Gaurav Sahay, Teresa I. Limjoco, and Yousef Shweihat
- Subjects
Drug induced sarcoid like reaction ,Granulomatosis reactivation ,PD-1 inhibitors side effect ,Diseases of the respiratory system ,RC705-779 - Abstract
Sarcoid like reaction is a well-known entity that occurs as a consequence to several malignancies or their therapies. Immunotherapy has gained a lot of interest in the past few years and has recently gained approval as first line therapy in multiple advanced stage malignancies. Pneumonitis has been described as complication of such therapy. Granulomatous inflammation has been only rarely reported subsequent to immunotherapy. We describe a case of granulomatous inflammation reactivation affecting the lungs in a patient previously exposed to Pembrolizumab and have evidence of a distant granulomatous infection. We discuss potential mechanisms of the inflammation and assert the importance of immunosuppression in controlling the dis-inhibited immune system.
- Published
- 2017
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