Search

Your search keyword '"Majchrzak, Mark"' showing total 105 results
Start Over Author "Majchrzak, Mark"
105 results on '"Majchrzak, Mark"'

1. Cerebral Proteomic Changes in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 With Cortical Microhemorrhages and Cognitive Impairments.

Author

Schrader, Joseph M, Majchrzak, Mark, Xu, Feng, Lee, Hedok, Agostinucci, Kevin, Davis, Judianne, Benveniste, Helene, and Van Nostrand, William E

Subjects
*TRANSFORMING growth factors-beta, *LABORATORY rats, *CEREBRAL amyloid angiopathy, *ALZHEIMER'S disease, *MAGNETIC resonance imaging
Abstract

Cerebral amyloid angiopathy (CAA) is a common disorder of the elderly, a prominent comorbidity of Alzheimer's disease, and causes vascular cognitive impairment and dementia. Previously, we generated a novel transgenic rat model (rTg-D) that produces human familial CAA Dutch E22Q mutant amyloid β-protein (Aβ) in brain and develops arteriolar CAA type-2. Here, we show that deposition of fibrillar Aβ promotes arteriolar smooth muscle cell loss and cerebral microhemorrhages that can be detected by magnetic resonance imaging and confirmed by histopathology. Aged rTg-D rats also present with cognitive deficits. Cerebral proteomic analyses revealed 241 proteins that were significantly elevated with an increase of >50% in rTg-D rats presenting with CAA compared to wild-type rats. Fewer proteins were significantly decreased in rTg-D rats. Of note, high temperature requirement peptidase A (HTRA1), a proteinase linked to transforming growth factor beta 1 (TGF-β1) signaling, was elevated and found to accumulate in cerebral vessels harboring amyloid deposits. Pathway analysis indicated elevation of the TGF-β1 pathway and increased TGF-β1 levels were detected in rTg-D rats. In conclusion, the present findings provide new molecular insights into the pathogenesis of CAA and suggest a role for interactions between HTRA1 and TGF-β1 in the disease process. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

12. Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects

Author

Wager, Travis T., primary, Chappie, Thomas, additional, Horton, David, additional, Chandrasekaran, Ramalakshmi Y., additional, Samas, Brian, additional, Dunn-Sims, Elizabeth R., additional, Hsu, Cathleen, additional, Nawreen, Nawshaba, additional, Vanase-Frawley, Michelle A., additional, O’Connor, Rebecca E., additional, Schmidt, Christopher J., additional, Dlugolenski, Keith, additional, Stratman, Nancy C., additional, Majchrzak, Mark J., additional, Kormos, Bethany L., additional, Nguyen, David P., additional, Sawant-Basak, Aarti, additional, and Mead, Andy N., additional

Published
2016
Full Text
View/download PDF

16. A novel series of [3.2.1] azabicyclic biaryl ethers as α3β4 and α6/4β4 nicotinic receptor agonists

Author

Lowe, John A., III, DeNinno, Shari L., Coe, Jotham W., Zhang, Lei, Mente, Scot, Hurst, Raymond S., Mather, Robert J., Ward, Karen M., Shrikhande, Alka, Rollema, Hans, Johnson, David E., Horner, Weldon, Gorczyca, Roxanne, Tingley, F. David, III, Kozak, Rouba, Majchrzak, Mark J., Tritto, Theresa, Sadlier, Jen, Shaffer, Chris L., Ellerbrock, Brenda, Osgood, Sarah M., MacDougall, Mary C., and McDowell, Laura L.

Published
2010
Full Text
View/download PDF

17. Mecamylamine pretreatment increases subsequent nicotine self-administration as indicated by changes in plasma nicotine level

Author

Behavioral Medicine Program, Department of Psychiatry, University of Michigan, 48105, Ann Arbor, MI, USA, Ann Arbor, Majchrzak, Mark J., Pomerleau, Cynthia S., Pomerleau, Ovide F., Behavioral Medicine Program, Department of Psychiatry, University of Michigan, 48105, Ann Arbor, MI, USA, Ann Arbor, Majchrzak, Mark J., Pomerleau, Cynthia S., and Pomerleau, Ovide F.

Abstract

Acute administration of mecamylamine, a centrally active nicotinic cholinergic agonist, has been shown to increase amount of smoking as indicated by smoking topography (e.g., puff rate, puff duration), expired carbon monoxide changes, and other inferential measures. In the present study, subjects showed significantly greater increases in plasma nicotine following smoking of two high-nicotine research cigarettes when pretreated with mecamylamine than when pretreated with placebo, even though no significant differences in puff volume or puff number were detected. Interestingly, none of our subjects reported nausea, although some achieved plasma nicotine levels at which nausea would typically be expected. We attribute the observed increases in nicotine intake to compensatory behavior designed to overcome mecamylamine's blocking effects.

Published
2006

18. Telemetric measurement of core temperature in pharmacological research: Validity and reliability

Author

Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, U.S.A., Dilsaver, Steven C., Majchrzak, Mark J., Alessi, Norman E., Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, U.S.A., Dilsaver, Steven C., Majchrzak, Mark J., and Alessi, Norman E.

Abstract

1. The authors present data establishing the reliability and validity of a method for telemetrically measuring core temperature. 2. The method is designed to be of particular utility to psychobiological researchers.

Published
2006

19. Effects of placebo (saline) injections on core temperature in the rat

Author

Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, U.S.A., Dilsaver, Steven C., Majchrzak, Mark J., Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, U.S.A., Dilsaver, Steven C., and Majchrzak, Mark J.

Abstract

1. Core temperature was telemetrically measured in 15 rats before (i.e., at baseline) and at 10-min intervals for 120 min following the injection of normal saline (1 ml/kg ip) or "no injection."2. The sample exhibited a mean temperature increase of 0.60 +/- 0.10[deg]C(mean +/- SEM) following injection.3. This differed significantly from the mean increase of 0.13 +/- 0.03[deg]C following "no injection" (p 4. The injection of saline (1 ml/kg) affected a mean rise in core temperature of 0.55 +/- 0.07[deg]C (p> 0.000001) in 46 animals in a second experiment.5. These data indicate that routine handling and a simple injection comprise significant and measurable stress which must be controlled in neuropharmacological studies employing a thermoregulation paradigm.

Published
2006

20. The effects of morphine on diet selection are dependent upon baseline diet preferences

Author

University of Michigan, Department of Psychiatry University Hospital, 8D8806, Box 0116, Ann Arbor, Michigan 48109-0116, USA, Gosnell, Blake A., Krahn, Dean D., Majchrzak, Mark J., University of Michigan, Department of Psychiatry University Hospital, 8D8806, Box 0116, Ann Arbor, Michigan 48109-0116, USA, Gosnell, Blake A., Krahn, Dean D., and Majchrzak, Mark J.

Abstract

It has been reported that morphine causes a selective increase in the intake of dietary fat. Because we have noted considerable variability among rats in their preferences for carbohydrate and fat, we reasoned that the effect of morphine on diet selection may differ in fat-preferring vs. carbohydrate-preferring rats. Male Sprague-Dawley rats were given ad lib access to separate sources of carbohydrate, fat and protein (Experiment 1), or to a carbohydrate/protein and a fat/protein diet (Experiment 2). After daily baseline intakes of the diets were determined, all rats were tested for feeding responses to subcutaneous injections of morphine (0, 2 and 10 mg/kg). Significant positive correlations were found between baseline daily intake of a given diet and the effect of morphine on the intake of that diet. Generally, morphine increased carbohydrate intake in carbohydrate-preferring rats, and increased fat intake in fat-preferring rats. These results suggest that the effect of morphine is to increase intake of a preferred diet rather than to increase intake of a specific macronutrient.

Published
2006

21. Centrally administered opioid peptides stimulate saccharin intake in nondeprived rats

Author

University of Michigan, Department of Psychiatry University Hospital, 8D8806, Box 0116, Ann Arbor, MI 48109-0116, USA, Gosnell, Blake A., Majchrzak, Mark J., University of Michigan, Department of Psychiatry University Hospital, 8D8806, Box 0116, Ann Arbor, MI 48109-0116, USA, Gosnell, Blake A., and Majchrzak, Mark J.

Abstract

Endogenous opioid peptides are thought to play a role in mediating the pleasurable or rewarding aspects of the ingestion of certain foods and liquids. We therefore measured the effects of central administration of selective opioid agonists and naloxone on the intake of two concentrations of saccharin solution. All tests were performed on nondeprived rats, such that the taste of the solutions provided the primary incentive to consume. Intracerebroventricular (ICV) administration of the selective mu agonist [D-Ala2,MePhe4,Gly-ol5]enkephalin (DAGO) and the selective delta agonist Tyr-D-Thr-Gly-Phe-Leu-Thr (DTLET) (3 nmol) increased intake of a 0.15% saccharin solution by approximately 10 ml over 3 hr. Water was available simultaneously, but intake was minimal. The selective kappa agonist U-50,488H did not increase intake of the saccharin solution. Naloxone (30 and 100 [mu]g, ICV) caused a 44% reduction in saccharin solution intake in the first hour; two- and three-hour cumulative intakes were not different from control. DAGO and DTLET were also tested when rats were given a weaker saccharin solution (0.006%) along with water. Both agonists caused small increases in saccharin and water intake, but the increases above baseline were much smaller than those observed with the more palatable 0.15% saccharin solution. These results are consistent with reports by others which suggest that endogenous opioids influence taste preferences or palatability. Further, they indicate a role for central mu and delta opioid receptors in the mediation of this influence.

Published
2006

22. Chronic treatment with amitriptyline produces supersensitivity to nicotine

Author

Mental Health Research Institute, Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA, Dilsaver, Steven C., Majchrzak, Mark J., Alessi, Norman E., Mental Health Research Institute, Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA, Dilsaver, Steven C., Majchrzak, Mark J., and Alessi, Norman E.

Abstract

The authors used a thermoregulation paradigm to evaluate effects of amitriptyline (AMI) on the sensitivity of a nicotinic mechanism involved in the regulation of core temperature in rats. Treatment with this tricyclic was associated with a significant increase in the hypothermie response to nicotine. Supersensitivity persisted for a minimum of 7.5 days following the last dose of AMI, and a significant proportion of animals displayed increased sensitivity after 14.5 days of abstinence. Implications for the mechanism of action of AMI are highlighted.

Published
2006

23. Phosphodiesterase 9A Regulates Central cGMP and Modulates Responses to Cholinergic and Monoaminergic Perturbation In Vivo

Author

Kleiman, Robin J., primary, Chapin, Douglas S., additional, Christoffersen, Curt, additional, Freeman, Jody, additional, Fonseca, Kari R., additional, Geoghegan, Kieran F., additional, Grimwood, Sarah, additional, Guanowsky, Victor, additional, Hajós, Mihály, additional, Harms, John F., additional, Helal, Christopher J., additional, Hoffmann, William E., additional, Kocan, Geralyn P., additional, Majchrzak, Mark J., additional, McGinnis, Dina, additional, McLean, Stafford, additional, Menniti, Frank S., additional, Nelson, Fredrick, additional, Roof, Robin, additional, Schmidt, Anne W., additional, Seymour, Patricia A., additional, Stephenson, Diane T., additional, Tingley, Francis David, additional, Vanase-Frawley, Michelle, additional, Verhoest, Patrick R., additional, and Schmidt, Christopher J., additional

Published
2012
Full Text
View/download PDF

24. Modulation of NMDA receptor function by inhibition of d-amino acid oxidase in rodent brain

Author

Strick, Christine A., primary, Li, Cheryl, additional, Scott, Liam, additional, Harvey, Brian, additional, Hajós, Mihály, additional, Steyn, Stefanus J., additional, Piotrowski, Mary A., additional, James, Larry C., additional, Downs, James T., additional, Rago, Brian, additional, Becker, Stacey L., additional, El-Kattan, Ayman, additional, Xu, Youfen, additional, Ganong, Alan H., additional, Tingley, F. David, additional, Ramirez, Andres D., additional, Seymour, Patricia A., additional, Guanowsky, Victor, additional, Majchrzak, Mark J., additional, Fox, Carol B., additional, Schmidt, Christopher J., additional, and Duplantier, Allen J., additional

Published
2011
Full Text
View/download PDF

25. P3‐380: Dendritic spine density deficits in the hippocampal CA1 region of young Tg2576 mice are ameliorated with the PDE9A inhibitor PF‐04447943

Author

Kleiman, Robin J., primary, Lanz, Thomas A., additional, Finley, James E., additional, Bove, Susan E., additional, Majchrzak, Mark J., additional, Becker, Stacey L., additional, Carvajal-Gonzales, Santos, additional, Kuhn, A. Max, additional, Wood, Kathleen M., additional, Mariga, Abigail, additional, Nelson, Frederick R., additional, Verhoest, Patrick R., additional, Seymour, Patricia A., additional, and Stephenson, Diane T., additional

Published
2010
Full Text
View/download PDF

26. Synthesis, sar and pharmacology of CP-293,019: A potent, selective dopamine D4 receptor antagonist

Author

Sanner, Mark A., primary, Chappie, Thomas A., additional, Dunaiskis, Audrey R., additional, Fliri, Anton F., additional, Desai, Kishor A., additional, Zorn, Stevin H., additional, Jackson, Elisa R., additional, Johnson, Celeste G., additional, Morrone, Jean M., additional, Seymour, Patricia A., additional, Majchrzak, Mark J., additional, Stephen Faraci, W., additional, Collins, Judith L., additional, Duignan, David B., additional, Di Prete, Cecilia C., additional, Lee, Jae S., additional, and Trozzi, Angela, additional

Published
1998
Full Text
View/download PDF

39. Nicotine Dependence and the Fagerström Tolerance Questionnaire: A Brief Review

Author

Pomerleau, Cynthia S., Majchrzak, Mark J., and Pomerleau, Ovide F.

Abstract

The Fagerström Tolerance Questionnaire (TQ) is widely used in both clinical and research settings as a measure of physiological dependence on nicotine. In the light of claims that the efficacy of nicotine gum is related to degree of dependence and that outcomes can be improved by tailoring gum strength to degree of dependence, the availability of a simple, noninvasive test of dependence assumes additional importance. Recently, a number of articles have expressed reservations about various aspects of the TQ: 1) Several TQ items suffer from flaws or ambiguities that undermine their usefulness, and 2) the TQ may not measure what it purports to measure. The present paper reviews these issues, assembles data and observations that bear on the problems, and makes suggestions that may help in refining the TQ or producing a better instrument.

Published
1989
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results