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Your search keyword '"Majchrzak, Agata"' showing total 29 results
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29 results on '"Majchrzak, Agata"'

1. 2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party

Author

Heuser, Michael, Freeman, Sylvie D., Ossenkoppele, Gert J., Buccisano, Francesco, Hourigan, Christopher S., Ngai, Lok Lam, Tettero, Jesse M., Bachas, Costa, Baer, Constance, Béné, Marie-Christine, Bücklein, Veit, Czyz, Anna, Denys, Barbara, Dillon, Richard, Feuring-Buske, Michaela, Guzman, Monica L., Haferlach, Torsten, Han, Lina, Herzig, Julia K., Jorgensen, Jeffrey L., Kern, Wolfgang, Konopleva, Marina Y., Lacombe, Francis, Libura, Marta, Majchrzak, Agata, Maurillo, Luca, Ofran, Yishai, Philippe, Jan, Plesa, Adriana, Preudhomme, Claude, Ravandi, Farhad, Roumier, Christophe, Subklewe, Marion, Thol, Felicitas, van de Loosdrecht, Arjan A., van der Reijden, Bert A., Venditti, Adriano, Wierzbowska, Agnieszka, Valk, Peter J.M., Wood, Brent L., Walter, Roland B., Thiede, Christian, Döhner, Konstanze, Roboz, Gail J., and Cloos, Jacqueline

Published
2021
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8. The Expression of mi-RNAs Involved in the Hematopoietic Niche Microenvironment in Newly Diagnosed AML Patients

Author

Czemerska, Magdalena, primary, Wisnik, Aneta, additional, Jarych, Dariusz, additional, Zawlik, Izabela, additional, Strzałka, Piotr, additional, Krawiec, Kinga, additional, Cebula-Obrzut, Barbara, additional, Majchrzak, Agata, additional, Brzozowski, Kamil, additional, Kozlowski, Marcin, additional, Pluta, Agnieszka, additional, and Wierzbowska, Agnieszka, additional

Published
2022
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11. The role of NF-κB and Smac/DIABLO proteins in the treatment response and survival of acute myeloid leukemia patients

Author

Pluta, Agnieszka, primary, Robak, Tadeusz, additional, Cebula, Barbara, additional, Majchrzak, Agata, additional, Pluta, Piotr, additional, Brzozowski, Kamil, additional, Stępka, Konrad, additional, Szmigielska-Kapłon, Anna, additional, Grzybowska-Izydorczyk, Olga, additional, Czemerska, Magdalena, additional, Smolewski, Piotr, additional, and Wierzbowska, Agnieszka, additional

Published
2021
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12. Atypical immunophenotype of chronic lymphocytic leukemia.

Author

Urbaniak, Marta, Iskierka-Jazdzewska, Elzbieta, Majchrzak, Agata, and Robak, Tadeusz

Subjects
CHRONIC lymphocytic leukemia, ANTIGENS, CD5 antigen, CD19 antigen, CD23 antigen
Abstract

Assessment of the immunophenotype plays a crucial role in the diagnostic process of chronic lymphocytic leukemia (CLL). The expression of CD5, CD19 and CD23 antigens with a concomitant reduction or lack of surface immunoglobulin expression as well as CD22 and CD79b antigens is the basic part of CLL diagnosis. A significant diagnostic challenge is atypical CLL with cells devoid of CD5 or CD23 antigens. The assessment of additional antigens in flow cytometry, especially the CD200 glycoprotein, may facilitate the process of differential diagnosis of atypical CLL from other B-cell lymphoproliferative neoplasms. The results of current studies analyzing the influence of atypical CLL on prognosis are inconclusive. The analysis of a large group of patients with atypical CLL is difficult because of the rare occurrence of CD5(–) or CD23(–) CLL and the misdiagnosis of this disease as other B-cell lymphoproliferative neoplasms. The following paper aims to show how important it is to include atypical CLL in the diagnostic process of this disease and to re-standardize the commonly used immunophenotypic scales for its diagnosis. [ABSTRACT FROM AUTHOR]

Published
2022
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13. The role of neuronal apoptosis inhibitory protein (NAIP) in acute myeloid leukemia patients

Author

Pluta, Agnieszka, primary, Robak, Tadeusz, additional, Brzozowski, Kamil, additional, Cebula-Obrzut, Barbara, additional, Majchrzak, Agata, additional, Pluta, Piotr, additional, Szmigielska-Kapłon, Anna, additional, Grzybowska-Izydorczyk, Olga, additional, Czemerska, Magdalena, additional, Stelmach, Piotr, additional, Smolewski, Piotr, additional, and Wierzbowska, Agnieszka, additional

Published
2019
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15. The Role of Radiotherapy in Hodgkin’s Lymphoma: What Has Been Achieved during the Last 50 Years?

Author

Witkowska, Magdalena, Majchrzak, Agata, and Smolewski, Piotr

Subjects
Article Subject
Abstract

Currently, Hodgkin’s lymphoma (HL) has an excellent clinical outcome, with overall survival of approximately 90% in early stages of the disease. Based on young age of the majority of patients at the time of diagnosis and their long survival time, increased attention has been focused on long-term toxicity of therapy. While novel, directly targeting antitumor agents, with an excellent safety profile, have been developed for HL treatment, the role of radiotherapy is still debated. Radiotherapy may induce cardiovascular disease and impairment of thyroid or pulmonary function and, most importantly, may lead to development of secondary cancers. As a consequence, the current radiation therapy planning paradigm is mainly focused on a reduction of field size. As it was investigated in clinical trials regional therapy is as effective as extended field radiotherapy, but less toxic. Although chemotherapy is the mainstay of HL treatment, consolidative involved field radiation therapy is still considered to be the standard of care in both early and advanced stages. Recently, further field reduction has been investigated to further decrease the late radiation-induced toxicity. In this paper we describe the role and safety profile of radiotherapy in the past and present and hope for the novel techniques in the future.

Published
2015
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21. Cytotoxic activity of the amphibian ribonucleases onconase and r-amphinase on tumor cells from B cell lymphoproliferative disorders

Author

SMOLEWSKI, PIOTR, primary, WITKOWSKA, MAGDALENA, additional, ZWOLINSKA, MALGORZATA, additional, CEBULA-OBRZUT, BARBARA, additional, MAJCHRZAK, AGATA, additional, JESKE, ALEKSANDRA, additional, DARZYNKIEWICZ, ZBIGNIEW, additional, ARDELT, WOJCIECH, additional, ARDELT, BARBARA, additional, and ROBAK, TADEUSZ, additional

Published
2014
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25. Pro-Apoptotic Activity of New Honokiol/Triphenylmethane Analogues in B-Cell Lymphoid Malignancies.

Author

Mçdra, Aleksandra, Witkowska, Magdalena, Majchrzak, Agata, Cebula-Obrzut, Barbara, Bonner, Michael Y., Robak, Tadeusz, Arbiser, Jack L., and Smolewski, Piotr

Subjects
APOPTOTIC bodies, VAT dyes, B cells, LYMPHOID tissue, CHRONIC lymphocytic leukemia, LYMPHOCYTES
Abstract

Honokiol and triphenylmethanes are small molecules with anti-tumor properties. Recently, we synthesized new honokiol analogues (HAs) that possess common features of both groups. We assessed the anti-tumor effectiveness of HAs in B-cell leukemia/lymphoma cells, namely in chronic lymphocytic leukemia (CLL) cells ex vivo and in pre-B-cell acute lymphoblastic leukemia (Nalm-6), Burkitt lymphoma (BL; Raji), diffuse large B-cell lymphoma (DLBCL; Toledo) and multiple myeloma (MM; RPMI 8226) cell lines. Four of these compounds appeared to be significantly active against the majority of cells examined, with no significant impact on healthy lymphocytes. These active HAs induced caspase-dependent apoptosis, causing significant deregulation of several apoptosis-regulating proteins. Overall, these compounds downregulated Bcl-2 and XIAP and upregulated Bax, Bak and survivin proteins. In conclusion, some of the HAs are potent tumor-selective inducers of apoptosis in ex vivo CLL and in BL, DLBCL and MM cells in vitro. Further preclinical studies of these agents are recommended. [ABSTRACT FROM AUTHOR]

Published
2016
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28. Antitumor Activity of Amphibian Ribonucleases, Onconase and R-Amhinase, on Tumor Cells From B-Cell Lymphoproliferative Disorders

Author

Smolewski, Piotr, primary, Zwoliñska, Malgorzata, additional, Cebula-Obrzut, Barbara, additional, Majchrzak, Agata, additional, Misiewicz, Malgorzata, additional, Jeske, Aleksandra, additional, Darzynkiewicz, Zbigniew, additional, Ardelt, Wojciech, additional, Ardelt, Barbara, additional, Saxena, Shailendra K, additional, Muniz, Charles, additional, and Robak, Tadeusz, additional

Published
2010
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