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4 results on '"Maja Kinkela Devčić"'

1. Oral Candidal Colonization in Patients with Different Prosthetic Appliances

Author

Maja Kinkela Devcic, Suncana Simonic-Kocijan, Jelena Prpic, Igor Paskovic, Tomislav Cabov, Zoran Kovac, and Irena Glazar

Subjects
Candida species, oral colonization, oral lesions, prosthetic appliances, salivary flow rate, Biology (General), QH301-705.5
Abstract

Oral infections caused by Candida species are becoming more common, which may be related to an increase in the number of immunologically compromised patients as well as favorable conditions in the oral cavity that often include removable prosthetic appliances. The purpose of this study was to determine the presence of a particular Candida species in patients with PMMA and Cr-Co prosthetic appliances, as well as the salivary flow rate, and oral signs and symptoms. This investigation included a total of 120 subjects with different kinds of removable dentures. A sample of concentrated oral rinse was collected from all subjects in order to detect Candida colonization and identify the Candida species, a quantum of salivation was measured, and subjects were examined clinically. Candida spp. was predominant among the subjects who were denture wearers (p < 0.0001). In all subjects, the most frequently detected species was C.albicans. A statistically significant difference was found between the prevalence of C.albicans (p < 0.001) and C.krusei (p < 0.001) in denture wearers. Subjects with PMMA-based removable prosthetic appliances mostly demonstrated a significant decrease in salivation (p < 0.001), an increase in burning sensations (p < 0.001), and dry mouth (p < 0.001) compared to the subjects who wore partial dentures with Co–Cr metallic frameworks. Red oral lesions were more frequently found among the subjects with partial dentures with Co–Cr metallic frameworks (p < 0.001). Regardless of the material used for the denture, patients must be regularly checked by their dentists in order to prevent the development of oral lesions.

Published
2021
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2. Antimicrobial Activity of Olive Leaf Extract to Oral Candida Isolates

Author

Maja Kinkela Devčić, Igor Pasković, Zoran Kovač, Petra Tariba Knežević, Luka Morelato, Irena Glažar, and Sunčana Simonić-Kocijan

Subjects
antifungal activity, Candida spp, olive leaf extract, Biology (General), QH301-705.5
Abstract

Objectives: The aim of this study was to determine the antifungal activity of olive leaf extract (OLE) and the synergistic effect of standard antifungal therapy and OLE against clinical oral Candida species’ isolates. Materials and Method: The susceptibility of 60 clinical isolates of the Candida species (36 C. albicans, 16 C. krusei, 5 C. glabrata and 3 C. tropicalis) was tested with four concentrations of OLE (60 µg/µL, 120 µg/µL, 240 µg/µL and 333 µg/µL) and the synergistic effect of standard antifungal therapy and OLE (miconazole (MIC) + 333 µg/µL OLE and nystatin (NYS) + 333 µg/µL OLE). The antimicrobial activity was tested using the disk diffusion method. Results: All concentrations (60 µg/µL, 120 µg/µL, 240 µg/µL and 333 µg/µL) of OLE showed a statistically significant effect on all Candida species compared to the control (DMSO) except for the lowest concentration (60 µg/µL) tested on C. glabrata. There was a dose-dependent effect of OLE on tested samples. Concentrations of 240 µg/µL and 333 µg/µL showed statistically significant higher antifungal activity compared to the lowest concentration of 60 µg/µL. No statistically significant synergistic effect of OLE and standard antifungal therapy was found compared with standard therapy alone. Conclusions: The results of this study present the significant antimicrobial effect of OLE against all tested Candida species except for the lowest concentration on C. glabrata. Increasing the concentration of OLE also increases its effect on Candida species. This indicates the possible potential effect of OLE in the treatment of Candida-related oral diseases.

Published
2024
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3. Ortodontsko i implantoprotetsko zbrinjavanje hipodoncije gornjih lateralnih inciziva uz retenciju oba gornja očnjaka pomoću kirurške vodilice

Author

Luka Morelato, Goran Milohanić, Ines Morelato, Elio Morelato, Davor Vučinić, and Maja Kinkela Devčić

Subjects
hipodoncija, retencirani zubi, kirurška vodilica, implanto-protetika
Abstract

Lateralni incizivi nakon umnjaka najčešći su hipodontni zubi gornje čeljusti, te zbog estetskog aspekta vidljivosti pri osmjehu predstavljaju zahtjevan ortodontski i protetski problem pri rješavanju. U prikazanom slučaju hipodoncija lateralnih inciziva pojavljuje se uz visoku retenciju oba gornja očnjaka. Zbog dobi pacijenta, visoke retencije očnjaka i upitne mogućnosti njihovog ortodontskog izvlačenja te mogućih komplikacija prilikom vađenja odlučeno je nakon ortodontske terapije provesti implantoprotetsku terapiju ostavljajući retinirane zube na njihovim pozicijama. Kako bi se implantološka terapija mogla provesti sa većom sigurnošću ne ugrožavajući okolne strukture i izbjegavanje postavljanja implantata u kontakt sa retiniranim zubima korištene su statičke kirurške vodilice za potpuno vođenu implantologiju stabilizirane na zubima. Korištenjem kirurških vodilica prenosimo planiranu situaciju pomoću dentalne kompjutorizirane tomografije (CB CT - engl. Cone Beam Computer Tomography) na kliničku situaciju u ustima uz zadovoljavajući stupanj preciznosti. Kirurška vodilica se planira i izrađuje nakon preciznog prostornog preklapanja CB CT snimke i digitaliziranog modela čeljusti pomoću više referentnih točaka. Nakon postavljanja dentalnih implantata pomoću vodilice i posebnog instrumentarija namijenjenog vođenoj implantologiji, implantati su imedijatno opterećeni privremenim protetskim nadomjescima kako bi se pacijentu u periodu osteointegracije omogućilo normalno funkcioniranje. Dovršetkom orotodontske terapije po uzimanju otisaka protetskim vijcima fiksira se definitivni protetski rad. U radu se naglašava važnost suradnje ortodonta, oralnog kirurga i doktora dentalne medicine koji se bavi protetskim dijelom terapije kako bi se uspješno riješio zahtjevan slučaj. Jednako tako naglašena je i važnost adekvatnog planiranja i mogućnost primjena kirurških vodilica u zahtjevnim slučajevima kod kojih se zahtjeva preciznost postave dentalnih implantata na planirane pozicije u posebno zahtjevnim slučajevima kada se vodilica s uporištem na zubima naslanja samo na dio zuba i nepca zbog ortodontskih bravica na bukalnim plohama.

Published
2022

4. UTJECAJ MATERIJALA MOBILNIH PROTETSKIH NADOMJESTAKA NA ZASTUPLJENOST CANDIDA SPP. U USNOJ ŠUPLJINI

Author

Maja Kinkela Devčić, Luka Morelato, Robert Vukman, Davor Vučinić, and Sunčana Simonić-Kocijan

Subjects
materijali mobilnih protetskih nadomjestaka, Candida spp, usna šupljina
Abstract

Uvod: Candida species (Candida spp.) je predstavnik fiziološke flore usne šupljine. Candida albicans je najzastupljenija, a od ostalih vrsta javljaju se Candida tropicalis, Candida glabrata, Candida parapsilosis, Candida krusei i Candida pseudotropicalis. Pacijenti s protetskim nadomjescima imaju veću predispoziciju kolonizacije usne šupljine Candidom spp. zbog razlike u površini materijala i stupnju poroznosti u uvjetima u usnoj šupljini. Cilj je ispitati utjecaj polimetil-metakrilata (PMMA) i kobalt krom (Co-Cr) legure na zastupljenost različitih vrsta Candida spp. u usnoj šupljini. Materijali i metode: Sudjelovalo je 120 ispitanika podijeljenih u tri skupine: Ispitanici s mobilnim protetskim nadomjestkom od polimetil- metakrilata PMMA ; ispitanici s mobilnim protetskim nadomjestkom s lijevanom metalnom bazom od kobalt- krom (Co-Cr) legure i ispitanici bez ikakvog protetskog nadomjestka (kontrolna skupina). Svakom ispitaniku uzet je uzorak usne šupljine metodom koncentriranog ispiranja. Uzorak je nasađen na CHROMagar Candida koji identificira pet vrsta Candide (C. albicans, C. Krusei, C. glabrata, C. tropicalis, Candida druge vrste) i inkubiran na 37°C/48h. Rezultati: Candida albicans je najzastupljenija vrsta u sve tri skupine. Značajno je više prisutno C. albicans (P

Published
2021

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