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1. Post-COVID-19 condition in children: epidemiological evidence stratified by acute disease severity

Author

Lap, Coen R., Brackel, Caroline L. H., Winkel, Angelique M. A. M., Hashimoto, Simone, Haverkort, Milly, Noij, Lieke C. E., Alsem, Mattijs W., von Asmuth, Erik G. J., Bannier, Michiel A. G. E., Buddingh, Emmeline P., van Goudoever, Johannes B., Haverman, Lotte, Maitland–van der Zee, Anke H., Mooij, Miriam G., Oostrom, Kim, Pijnenburg, Mariëlle W., Kloosterman, Sanne, Teela, Lorynn, Luijten, Michiel, Tulling, Adam J., Lugthart, Gertjan, Bogaert, Debby, Biesbroek, Giske, van Houten, Marlies A., and Terheggen-Lagro, Suzanne W. J.

Published
2024
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2. International Care programs for Pediatric Post-COVID Condition (Long COVID) and the way forward

Author

Brackel, Caroline L. H., Noij, Lieke C. E., Vijverberg, Susanne J. H., Legghe, Camille L., Maitland-van der Zee, Anke H., van Goudoever, Johannes B., Buonsenso, Danilo, Munblit, Daniel, Sigfrid, Louise, McFarland, Sammie, Anmyr, Lena, Ashkenazi-Hoffnung, Liat, Bellinat, Ana P. N., Dias, Nathália L. S., Edwards, Amy, Fashina, Tomini, Juraški, Romana Gjergja, Gonçalves, Ana L. N., Hansted, Edita, Herczeg, Vivien, Hertting, Olof, Jankauskaite, Lina N., Kaswandani, Nastiti, Kevalas, Rimantas, Krivácsy, Péter, Lorenz, Michael, Malone, Laura A., McVoy, Molly, Miller, David W., Morrow, Amanda K., Nugawela, Manjula D., Oliveira, Carlos R., Oliveira, Pablo R. S., Osmanov, Ismael M., Overmars, Isabella M., Paintsil, Elijah, Pinto Pereira, Snehal M., Prawira, Yogi, Putri, Nina Dwi, Ramos, Regina C. F., Rasche, Marius, Ryd-Rinder, Malin, De Rose, Christina, Samitova, Elmira, Jovanović, Tatjana Savić, Say, Daniela, Scott, Janet T., Shachar-Lavie, Iris, Shafran, Roz, Shmueli, Einat, Snipaitiene, Ausra, Stephenson, Terence, Ténai, Nikolett, Tosif, Shidan, Turkalj, Mirjana, Valentini, Piero, Vasconcelos, Luydson R. S., Villard, Li, Vilser, Daniel, Hashimoto, Simone, and Terheggen-Lagro, Suzanne W. J.

Published
2024
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5. Association between butyrate-producing gut bacteria and the risk of infectious disease hospitalisation: results from two observational, population-based microbiome studies

Author

Kullberg, Robert F J, Wikki, Irina, Haak, Bastiaan W, Kauko, Anni, Galenkamp, Henrike, Peters-Sengers, Hessel, Butler, Joe M, Havulinna, Aki S, Palmu, Joonatan, McDonald, Daniel, Benchraka, Chouaib, Abdel-Aziz, Mahmoud I, Prins, Maria, Maitland van der Zee, Anke H, van den Born, Bert-Jan, Jousilahti, Pekka, de Vos, Willem M, Salomaa, Veikko, Knight, Rob, Lahti, Leo, Nieuwdorp, Max, Niiranen, Teemu, and Wiersinga, W Joost

Published
2024
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6. Whole blood transcriptome in long-COVID patients reveals association with lung function and immune response

Author

Blankestijn, Jelle M., Baalbaki, Nadia, Bazdar, Somayeh, Beekers, Inés, Beijers, Rosanne J.H.C.G., van den Bergh, Joop P., Bloemsma, Lizan D., Cornelissen, Merel E.B., Dekker, Tamara, Duitman, Jan Willem, Houweling, Laura, Jacobs, John J.L., van der Lee, Ivo, Linders, Paulien M.A., Noij, Lieke C.E., Nossent, Esther J., van de Pol, Marianne A., Sondermeijer, Brigitte M., Geelhoed, J.J. Miranda, Weersink, Els J.M., Golebski, Korneliusz, Abdel-Aziz, Mahmoud I., and Maitland-van der Zee, Anke H.

Published
2024
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7. Reframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies

Author

Shankar-Hari, Manu, Calandra, Thierry, Soares, Miguel P, Bauer, Michael, Wiersinga, W Joost, Prescott, Hallie C, Knight, Julian C, Baillie, Kenneth J, Bos, Lieuwe D J, Derde, Lennie P G, Finfer, Simon, Hotchkiss, Richard S, Marshall, John, Openshaw, Peter J M, Seymour, Christopher W, Venet, Fabienne, Vincent, Jean-Louis, Le Tourneau, Christophe, Maitland-van der Zee, Anke H, McInnes, Iain B, and van der Poll, Tom

Published
2024
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9. Precision Medicine in Asthma Therapy

Author

Principe, Stefania, Vijverberg, Susanne J. H., Abdel-Aziz, Mahmoud I., Scichilone, Nicola, Maitland-van der Zee, Anke H., Michel, Martin C., Editor-in-Chief, Barrett, James E., Editorial Board Member, Centurión, David, Editorial Board Member, Flockerzi, Veit, Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Meier, Kathryn Elaine, Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Cascorbi, Ingolf, editor, and Schwab, Matthias, editor

Published
2023
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11. Cisplatin-induced nephrotoxicity in childhood cancer: comparison between two countries

Author

Zazuli, Zulfan, Op 't Hoog, Catharina J. P., Vijverberg, Susanne J. H., Masereeuw, Rosalinde, Rassekh, Shahrad Rod, Medeiros, Mara, Rivas-Ruiz, Rodolfo, Maitland-van der Zee, Anke H., and Carleton, Bruce C.

Subjects
Cisplatin -- Complications and side effects -- Statistics, Acute renal failure -- Risk factors -- Statistics, Cancer in children -- Drug therapy -- Statistics, Pediatric research, Health
Abstract

Background Various definitions used to describe cisplatin nephrotoxicity potentially lead to differences in determination of risk factors. This study evaluated incidence of kidney injury according to commonly used and alternative definitions in two cohorts of children who received cisplatin. Methods This retrospective cohort study included children from Vancouver, Canada (one center), and Mexico City, Mexico (two centers), treated with cisplatin for a variety of solid tumors. Serum creatinine-based definitions (KDIGO and Pediatric RIFLE (pRIFLE)), electrolyte abnormalities consisted of hypokalemia, hypophosphatemia and hypomagnesemia (based on NCI-CTCAE v5), and an alternative definition (Alt-AKI) were used to describe nephrotoxicity. Incidence with different definitions, definitional overlap, and inter-definition reliability was analyzed. Results In total, 173 children (100 from Vancouver, 73 from Mexico) were included. In the combined cohort, Alt-AKI criteria detected more patients with cisplatin nephrotoxicity compared to pRIFLE and KDIGO criteria (82.7 vs. 63.6 vs. 44.5%, respectively). Nephrotoxicity and all electrolyte abnormalities were significantly more common in Vancouver cohort than in Mexico City cohort except when using KDIGO definition. The most common electrolyte abnormalities were hypomagnesemia (88.9%, Vancouver) and hypophosphatemia (24.2%, Mexico City). The KDIGO definition provided highest overlap of cases in Vancouver (100%), Mexico (98.6%), and the combined cohort (99.4%). Moderate overall agreement was found among Alt-AKI, KDIGO, and pRIFLE definitions ([kappa] = 0.18, 95% CI 0.1-0.27) in which KDIGO and pRIFLE showed moderate agreement ([kappa] = 0.48, 95% CI 0.36-0.60). Conclusions Compared to pRIFLE and KDIGO criteria, Alt-AKI criteria detected more patients with cisplatin nephrotoxicity. pRIFLE is more sensitive to detect not only actual kidney injury but also patients at risk of cisplatin nephrotoxicity, while KDIGO seems more useful to detect clinically significant kidney injury. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information., Author(s): Zulfan Zazuli [sup.1] [sup.2] , Catharina J. P. Op 't Hoog [sup.3] , Susanne J. H. Vijverberg [sup.1] , Rosalinde Masereeuw [sup.3] , Shahrad Rod Rassekh [sup.4] , Mara [...]

Published
2023
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12. Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine

Author

Kurnat-Thoma, Emma, Baranova, Ancha, Baird, Pat, Brodsky, Elia, Butte, Atul J, Cheema, Amrita K, Cheng, Feixiong, Dutta, Shuchismita, Grant, Christina, Giordano, James, Maitland-van der Zee, Anke H, Fridsma, Douglas B, Jarrin, Robert, Kann, Maricel G, Keeney, Jonathon, Loscalzo, Joseph, Madhavan, Guru, Maron, Bradley A, McBride, Dennis K, McKean, Maeve, Mun, Seong K, Palmer, James C, Patel, Bakul, Parakh, Kapil, Pariser, Anne R, Pristipino, Christian, Radstake, Timothy RDJ, Rajasimha, Harsha K, Rouse, William B, Rozman, Damjana, Saleh, Alif, Schmidt, Harald HHW, Schultz, Nikolaus, Sethi, Tavpritesh, Silverman, Edwin K, Skopac, Jessica, Svab, Igor, Trujillo, Sylvia, Valentine, James E, Verma, Dinesh, West, Bruce J, and Vasudevan, Sona

Subjects
Biomedical and Clinical Sciences, Philosophy and Religious Studies, History and Philosophy Of Specific Fields, Generic health relevance, Good Health and Well Being, artificial intelligence, big data, ethical legal social implications, international conference, network medicine, regulatory and health policy, systems
Abstract

The First International Conference in Systems and Network Medicine gathered together 200 global thought leaders, scientists, clinicians, academicians, industry and government experts, medical and graduate students, postdoctoral scholars and policymakers. Held at Georgetown University Conference Center in Washington D.C. on September 11-13, 2019, the event featured a day of pre-conference lectures and hands-on bioinformatic computational workshops followed by two days of deep and diverse scientific talks, panel discussions with eminent thought leaders, and scientific poster presentations. Topics ranged from: Systems and Network Medicine in Clinical Practice; the role of -omics technologies in Health Care; the role of Education and Ethics in Clinical Practice, Systems Thinking, and Rare Diseases; and the role of Artificial Intelligence in Medicine. The conference served as a unique nexus for interdisciplinary discovery and dialogue and fostered formation of new insights and possibilities for health care systems advances.

Published
2020

14. Medication use in uncontrolled pediatric asthma: Results from the SysPharmPediA study

Author

Alizadeh Bahmani, Amir Hossein, Slob, Elise M.A., Bloemsma, Lizan D., Brandstetter, Susanne, Corcuera-Elosegui, Paula, Gorenjak, Mario, Harner, Susanne, Hashimoto, Simone, Hedman, Anna M., Kabesch, Michael, Koppelman, Gerard H., Korta-Murua, Javier, Kraneveld, Aletta D., Neerincx, Anne H., Pijnenburg, Mariëlle W., Pino-Yanes, Maria, Potočnik, Uroš, Sardón-Prado, Olaia, Vijverberg, Susanne J.H., Wolff, Christine, Abdel-Aziz, Mahmoud I., and Maitland-van der Zee, Anke H.

Published
2023
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15. Real-World Effectiveness of Reslizumab in Patients With Severe Eosinophilic Asthma – First Initiators and Switchers

Author

Hashimoto, Simone, Kroes, Johannes A., Eger, Katrien A., Mau Asam, Pearl F., Hofstee, Hendrik B., Bendien, Sarah A., Braunstahl, Gert Jan, Broeders, Marielle E.A.C., Imming, Leonie M., Langeveld, Bas, Maitland-van der Zee, Anke H., Oud, Karen T.M., Patberg, Kornelis Wiebe, Smeenk, Frank W.J.M., Romme, Elisabeth A.P.M., van Bezouw, Maarten J., van de Ven, Marjo J., van Veen, Anneke, van Velzen, Edwin, van Veen, Ilonka H.P.A.A., Weersink, Els J.M., Ten Brinke, Anneke, Sont, Jacob K., and Bel, Elisabeth H.

Published
2022
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17. Are single‐nucleotide polymorphisms previously linked to inhaled corticosteroid response associated with obese‐asthma in children?

Author

Longo, Cristina, Chiv, Richard, Xu, Zhongli, Forno, Erick, Chen, Wei, Boeck, Andreas, Granell, Raquel, Salvermoser, Michael, Schaub, Bianca, Celedón, Juan C., Turner, Stephen, Vijverberg, Susanne, and Maitland‐van der Zee, Anke H.

Subjects
ASTHMA in children, OVERWEIGHT children, SINGLE nucleotide polymorphisms, REGULATOR genes, RANDOM effects model, ASTHMATICS
Abstract

The article explores the association between single-nucleotide polymorphisms (SNPs) previously linked to inhaled corticosteroid response and obese-asthma in children. Childhood obesity is a significant risk factor for asthma development and may reduce response to conventional treatment. The study suggests that the SNP rs517762 in the NEGR1 gene, implicated in poor ICS response, is also associated with obesity in children with asthma. The findings highlight potential underlying mechanisms of the pediatric obese-asthma phenotype and call for further validation through prospective and functional studies. [Extracted from the article]

Published
2024
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18. The Progression of Symptoms in Post COVID-19 Patients: A Multicentre, Prospective, Observational Cohort Study.

Author

Cornelissen, Merel E. B., Haarman, Myrthe M., Twisk, Jos W. R., Houweling, Laura, Baalbaki, Nadia, Sondermeijer, Brigitte, Beijers, Rosanne J. H. C. G., Gach, Debbie, Bloemsma, Lizan D., and Maitland-van der Zee, Anke H.

Subjects
COVID-19, FATIGUE (Physiology), PULMONARY function tests, SYMPTOMS, LOGISTIC regression analysis
Abstract

Background: Although the coronavirus disease 2019 (COVID-19) pandemic is no longer a public health emergency of international concern, 30% of COVID-19 patients still have long-term complaints. A better understanding of the progression of symptoms after COVID-19 is needed to reduce the burden of the post COVID-19 condition. Objective: This study aims to investigate the progression of symptoms, identify patterns of symptom progression, and assess their associations with patient characteristics. Methods: Within the P4O2 COVID-19 study, patients aged 40–65 years were recruited from five Dutch hospitals. At 3–6 and 12–18 months post COVID-19, medical data were collected, and pulmonary function tests were performed. In between, symptoms were assessed monthly with a questionnaire. Latent class mixed modelling was used to identify symptom progression patterns over time, with multinomial logistic regression to examine associations with patient characteristics. Results: Eighty-eight patients (aged 54.4 years, 48.9% males) were included. Three trajectories were identified for fatigue and dyspnoea: decreasing, high persistent, and low persistent. The odds of "decreasing fatigue" was higher for never smokers and participants in the lifestyle intervention and lower for those having a comorbidity. The odds of "decreasing dyspnoea" was higher for moderate COVID-19 patients and lifestyle intervention participants and lower for males, mild COVID-19 patients, and those with a higher age. Conclusions: Three distinct trajectories were identified for fatigue and dyspnoea, delineating patterns of symptom persistence following COVID-19. Sex, age, smoking status, participation in lifestyle interventions and COVID-19 severity were associated with the likelihood of belonging to different trajectories. These findings highlight the heterogeneity of the long-term symptoms experienced by post COVID-19 patients and emphasise the importance of personalised treatment strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Fatigue in severe pediatric asthma patients: Results of the PANDA study.

Author

van Dijk, Yoni E., Keuker, Valerie S. L., Hashimoto, Simone, Rutjes, Niels W., van Muilekom, Maud M., Golebski, Kornel, Van Litsenburg, Raphaële R. L., Terheggen‐Lagro, Suzanne W. J., van Ewijk, Bart E., Gemke, Reinoud J. B. J., Maitland‐van der Zee, Anke H., and Vijverberg, Susanne J. H.

Subjects
ASTHMATICS, FATIGUE (Physiology), DUTCH people, ASTHMA in children, STANDARD deviations, CANCER fatigue
Abstract

Background: Fatigue is a commonly reported clinical symptom, yet research on fatigue in children with severe asthma is missing. We aimed to explore the extent of fatigue in severe pediatric asthma and identify associated factors. Method: This study was conducted within the Pediatric Asthma Non‐Invasive Diagnostic Approaches (PANDA), an observational cohort of 6‐ to 17‐year‐old Dutch children with severe asthma. The Pediatric Quality of Life Inventory Multidimensional Fatigue Scale (PedsQL™‐MFS) was used to measure self‐reported fatigue. Fatigue levels were compared with a general pediatric Dutch population using linear regression, and quantifying the prevalence of "fatigued" (−2 < Standard deviations [SD] ≤ −1) and "severely fatigued" (SD ≤ −2) children. Secondly, we performed linear regression analyses to explore whether fatigue levels were independently associated with asthma attacks, comorbidities, medication, pulmonary function, symptom control, and asthma‐related quality of life (QoL). Results: Severe pediatric asthma patients (n = 78, mean age 11.8 ± 3.1 years) reported significantly more fatigue than Dutch peers (n = 328, mean age 11.8 ± 3.2 years) mean difference in z‐score: −0.68; 95%CI −0.96, −0.40. In the severe asthma group, 28.2% scored as "fatigued" and 15.4% as "severely fatigued," compared with 14.0% and 3.4% in the general population. In pediatric asthma patients, asthma‐related QoL (β = 0.77, p <.01, ΔR2 =.43), symptom control (β = 0.56, p <.01, ΔR2 =.24) and a dysfunctional breathing pattern (β = −0.36, p <.01, ΔR2 =.12) were most strongly associated with fatigue scores. Conclusion: Fatigue is a common symptom in children with severe asthma and is associated with multiple clinical factors and patient‐reported outcomes. It should be considered as an important treatment target. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Mapping atopic dermatitis and anti–IL-22 response signatures to type 2–low severe neutrophilic asthma

Author

Badi, Yusef Eamon, Pavel, Ana B., Pavlidis, Stelios, Riley, John H., Bates, Stewart, Kermani, Nazanin Zounemat, Knowles, Richard, Kolmert, Johan, Wheelock, Craig E., Worsley, Sally, Uddin, Mohib, Alving, Kjell, Bakke, Per S., Behndig, Annelie, Caruso, Massimo, Chanez, Pascal, Fleming, Louise J., Fowler, Stephen J., Frey, Urs, Howarth, Peter, Horváth, Ildikó, Krug, Norbert, Maitland-van der Zee, Anke H., Montuschi, Paolo, Roberts, Graham, Sanak, Marek, Shaw, Dominick E., Singer, Florian, Sterk, Peter J., Djukanovic, Ratko, Dahlen, Sven-Eric, Guo, Yi-Ke, Chung, Kian Fan, Guttman-Yassky, Emma, and Adcock, Ian M.

Published
2022
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25. Long COVID exhibits clinically distinct phenotypes at 3–6 months post-SARS-CoV-2 infection: results from the P4O2 consortium

Author

Blankestijn, Jelle M, primary, Abdel-Aziz, Mahmoud I, additional, Baalbaki, Nadia, additional, Bazdar, Somayeh, additional, Beekers, Inés, additional, Beijers, Rosanne J H C G, additional, Bloemsma, Lizan D, additional, Cornelissen, Merel E B, additional, Gach, Debbie, additional, Houweling, Laura, additional, Holverda, Sebastiaan, additional, Jacobs, John J L, additional, Jonker, Reneé, additional, van der Lee, Ivo, additional, Linders, Paulien M A, additional, Mohamed Hoesein, Firdaus A A, additional, Noij, Lieke C E, additional, Nossent, Esther J, additional, van de Pol, Marianne A, additional, Schaminee, Daphne W, additional, Schols, Annemie M W J, additional, Schuurman, Lisanne T, additional, Sondermeijer, Brigitte, additional, Geelhoed, J J Miranda, additional, van den Bergh, Joop P, additional, Weersink, Els J M, additional, de Wit-van Wijck, Yolanda, additional, and Maitland-van der Zee, Anke H, additional

Published
2024
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30. Precision Medicine in Asthma Therapy

Author

Principe, Stefania, primary, Vijverberg, Susanne J. H., additional, Abdel-Aziz, Mahmoud I., additional, Scichilone, Nicola, additional, and Maitland-van der Zee, Anke H., additional

Published
2022
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31. Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis

Author

Maagdenberg, Hedy, Oosterom, Natanja, Zanen, Jolanda, Gemmati, Donato, Windsor, Rachael E., Heil, Sandra G., Esperón, Patricia, Jabeen, Shakila, Ruiz-Argüelles, Guillermo J., Zolk, Oliver, Hoerning, Susanne, Sleurs, Charlotte, Lopéz-Lopéz, Elixabet, Moreno-Galván, Mónica, van den Heuvel-Eibrink, Marry M., Maitland-van der Zee, Anke H., and Carleton, Bruce C.

Published
2021
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33. Hemoglobin and Its Relationship with Fatigue in Long-COVID Patients Three to Six Months after SARS-CoV-2 Infection

Author

P4O2 Consortium, Bazdar, Somayeh, Bloemsma, Lizan D, Baalbaki, Nadia, Blankestijn, Jelle M, Cornelissen, Merel E B, Beijers, Rosanne J H C G, Sondermeijer, Brigitte M, van Wijck, Yolanda, Downward, George S, Maitland-van der Zee, Anke H, P4O2 Consortium, Bazdar, Somayeh, Bloemsma, Lizan D, Baalbaki, Nadia, Blankestijn, Jelle M, Cornelissen, Merel E B, Beijers, Rosanne J H C G, Sondermeijer, Brigitte M, van Wijck, Yolanda, Downward, George S, and Maitland-van der Zee, Anke H

Abstract

Background: While some long-term effects of COVID-19 are respiratory in nature, a non-respiratory effect gaining attention has been a decline in hemoglobin, potentially mediated by inflammatory processes. In this study, we examined the correlations between hemoglobin levels and inflammatory biomarkers and evaluated the association between hemoglobin and fatigue in a cohort of Long-COVID patients. Methods: This prospective cohort study in the Netherlands evaluated 95 (mostly hospitalized) patients, aged 40-65 years, 3-6 months post SARS-CoV-2 infection, examining their venous hemoglobin concentration, anemia (hemoglobin < 7.5 mmol/L in women and <8.5 mmol/L in men), inflammatory blood biomarkers, average FSS (Fatigue Severity Score), demographics, and clinical features. Follow-up hemoglobin was compared against hemoglobin during acute infection. Spearman correlation was used for assessing the relationship between hemoglobin concentrations and inflammatory biomarkers, and the association between hemoglobin and fatigue was examined using logistic regression. Results: In total, 11 (16.4%) participants were suffering from anemia 3-6 months after SARS-CoV-2 infection. The mean hemoglobin value increased by 0.3 mmol/L 3-6 months after infection compared to the hemoglobin during the acute phase ( p-value = 0.003). Whilst logistic regression showed that a 1 mmol/L greater increase in hemoglobin is related to a decrease in experiencing fatigue in Long-COVID patients (adjusted OR 0.38 [95%CI 0.13-1.09]), we observed no correlations between hemoglobin and any of the inflammatory biomarkers examined. Conclusion: Our results indicate that hemoglobin impairment might play a role in developing Long-COVID fatigue. Further investigation is necessary to identify the precise mechanism causing hemoglobin alteration in these patients.

Published
2024

34. Long COVID exhibits clinically distinct phenotypes at 3–6 months post-SARSCoV-2 infection: results from the P4O2 consortium

Author

on behalf of the P4O2 consortium, Blankestijn, Jelle M., Abdel-Aziz, Mahmoud I., Baalbaki, Nadia, Bazdar, Somayeh, Beekers, Inés, Beijers, Rosanne J.H.C.G., Bloemsma, Lizan D., Cornelissen, Merel E.B., Gach, Debbie, Houweling, Laura, Holverda, Sebastiaan, Jacobs, John J.L., Jonker, Reneé, van der Lee, Ivo, Linders, Paulien M.A., Mohamed Hoesein, Firdaus A.A., Noij, Lieke C.E., Nossent, Esther J., van de Pol, Marianne A., Schaminee, Daphne W., Schols, Annemie M.W.J., Schuurman, Lisanne T., Sondermeijer, Brigitte, Geelhoed, J. J.Miranda, van den Bergh, Joop P., Weersink, Els J.M., de Wit-Van Wijck, Yolanda, Maitland-Van der Zee, Anke H., on behalf of the P4O2 consortium, Blankestijn, Jelle M., Abdel-Aziz, Mahmoud I., Baalbaki, Nadia, Bazdar, Somayeh, Beekers, Inés, Beijers, Rosanne J.H.C.G., Bloemsma, Lizan D., Cornelissen, Merel E.B., Gach, Debbie, Houweling, Laura, Holverda, Sebastiaan, Jacobs, John J.L., Jonker, Reneé, van der Lee, Ivo, Linders, Paulien M.A., Mohamed Hoesein, Firdaus A.A., Noij, Lieke C.E., Nossent, Esther J., van de Pol, Marianne A., Schaminee, Daphne W., Schols, Annemie M.W.J., Schuurman, Lisanne T., Sondermeijer, Brigitte, Geelhoed, J. J.Miranda, van den Bergh, Joop P., Weersink, Els J.M., de Wit-Van Wijck, Yolanda, and Maitland-Van der Zee, Anke H.

Abstract

Background Four months after SARS-CoV-2 infection, 22%–50% of COVID-19 patients still experience complaints. Long COVID is a heterogeneous disease and finding subtypes could aid in optimising and developing treatment for the individual patient. Methods Data were collected from 95 patients in the P4O2 COVID-19 cohort at 3–6 months after infection. Unsupervised hierarchical clustering was performed on patient characteristics, characteristics from acute SARSCoV-2 infection, long COVID symptom data, lung function and questionnaires describing the impact and severity of long COVID. To assess robustness, partitioning around medoids was used as alternative clustering. Results Three distinct clusters of patients with long COVID were revealed. Cluster 1 (44%) represented predominantly female patients (93%) with pre-existing asthma and suffered from a median of four symptom categories, including fatigue and respiratory and neurological symptoms. They showed a milder SARS-CoV-2 infection. Cluster 2 (38%) consisted of predominantly male patients (83%) with cardiovascular disease (CVD) and suffered from a median of three symptom categories, most commonly respiratory and neurological symptoms. This cluster also showed a significantly lower forced expiratory volume within 1 s and diffusion capacity of the lung for carbon monoxide. Cluster 3 (18%) was predominantly male (88%) with pre-existing CVD and diabetes. This cluster showed the mildest long COVID, and suffered from symptoms in a median of one symptom category. Conclusions Long COVID patients can be clustered into three distinct phenotypes based on their clinical presentation and easily obtainable information. These clusters show distinction in patient characteristics, lung function, long COVID severity and acute SARS-CoV-2 infection severity. This clustering can help in selecting the most beneficial monitoring and/or treatment strategies for patients suffering from long COVID. Follow-up research is needed to reveal the un

Published
2024

35. Fatigue and symptom-based clusters in post COVID-19 patients: a multicentre, prospective, observational cohort study

Author

Cornelissen, Merel E.B., Bloemsma, Lizan D., Vaes, Anouk W., Baalbaki, Nadia, Deng, Qichen, Beijers, Rosanne J.H.C.G., Noij, Lieke C.E., Houweling, Laura, Bazdar, Somayeh, Spruit, Martijn A., Maitland-van der Zee, Anke H., Cornelissen, Merel E.B., Bloemsma, Lizan D., Vaes, Anouk W., Baalbaki, Nadia, Deng, Qichen, Beijers, Rosanne J.H.C.G., Noij, Lieke C.E., Houweling, Laura, Bazdar, Somayeh, Spruit, Martijn A., and Maitland-van der Zee, Anke H.

Abstract

Background: In the Netherlands, the prevalence of post COVID-19 condition is estimated at 12.7% at 90–150 days after SARS-CoV-2 infection. This study aimed to determine the occurrence of fatigue and other symptoms, to assess how many patients meet the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) criteria, to identify symptom-based clusters within the P4O2 COVID-19 cohort and to compare these clusters with clusters in a ME/CFS cohort. Methods: In this multicentre, prospective, observational cohort in the Netherlands, 95 post COVID-19 patients aged 40–65 years were included. Data collection at 3–6 months after infection included demographics, medical history, questionnaires, and a medical examination. Follow-up assessments occurred 9–12 months later, where the same data were collected. Fatigue was determined with the Fatigue Severity Scale (FSS), a score of ≥ 4 means moderate to high fatigue. The frequency and severity of other symptoms and the percentage of patients that meet the ME/CFS criteria were assessed using the DePaul Symptom Questionnaire-2 (DSQ-2). A self-organizing map was used to visualize the clustering of patients based on severity and frequency of 79 symptoms. In a previous study, 337 Dutch ME/CFS patients were clustered based on their symptom scores. The symptom scores of post COVID-19 patients were applied to these clusters to examine whether the same or different clusters were found. Results: According to the FSS, fatigue was reported by 75.9% of the patients at 3–6 months after infection and by 57.1% of the patients 9–12 months later. Post-exertional malaise, sleep disturbances, pain, and neurocognitive symptoms were also frequently reported, according to the DSQ-2. Over half of the patients (52.7%) met the Fukuda criteria for ME/CFS, while fewer patients met other ME/CFS definitions. Clustering revealed specific symptom patterns and showed that post COVID-19 patients occurred in 11 of the clusters that have been observed in the M

Published
2024

36. The effects of the COVID-19 pandemic on PICU admissions for severe asthma exacerbations: A single-center experience

Author

Bazdar, Somayeh, van den Berg, Sarah, Rutjes, Niels W, Bloemsma, Lizan D, Downward, George S, De Weger, Letty A, Terheggen-Lagro, Suzanne W J, van Wijck, Yolanda, Maitland van der Zee, Anke H, Kapitein, Berber, Bazdar, Somayeh, van den Berg, Sarah, Rutjes, Niels W, Bloemsma, Lizan D, Downward, George S, De Weger, Letty A, Terheggen-Lagro, Suzanne W J, van Wijck, Yolanda, Maitland van der Zee, Anke H, and Kapitein, Berber

Abstract

BACKGROUND: The incidence of severe asthma exacerbations (SAE) requiring a pediatric intensive care unit (PICU) admission during the coronavirus disease 2019 (COVID-19) pandemic (and its association with public restrictions) is largely unknown. We examined the trend of SAE requiring PICU admission before, during, and after COVID-19 restrictions in Amsterdam, the Netherlands, and its relationship with features such as environmental triggers and changes in COVID-19 restriction measures.METHODS: In this single-center, retrospective cohort study, all PICU admissions of children aged ≥2 years for severe asthma at the Amsterdam UMC between 2018 and 2022 were included. The concentrations of ambient fine particulate matter (PM 2.5 ) and pollen were obtained from official monitoring stations. RESULTS: Between January 2018 and December 2022, 228 children were admitted to the PICU of the Amsterdam UMC for SAE. While we observed a decrease in admissions during periods of more stringent restriction, there was an increase in the PICU admission rate for SAE in some periods following the lifting of restrictions. In particular, following the COVID-19 restrictions in 2021, we observed a peak incidence of admissions from August to November, which was higher than any other peak during the indicated years. No association with air pollution or pollen was observed.CONCLUSION: We hypothesize that an increase in clinically diagnosed viral infections after lockdown periods was the reason for the altered incidence of SAE at the PICU in late 2021, rather than air pollution and pollen concentrations.

Published
2024

37. Hemoglobin and Its Relationship with Fatigue in Long-COVID Patients Three to Six Months after SARS-CoV-2 Infection

Author

Planetary Health & Exposoom, Bazdar, Somayeh, Bloemsma, Lizan D., Baalbaki, Nadia, Blankestijn, Jelle M., Cornelissen, Merel E.B., Beijers, Rosanne J.H.C.G., Sondermeijer, Brigitte M., van Wijck, Yolanda, Downward, George S., Maitland-van der Zee, Anke H., on behalf of the P4O2 Consortium, Planetary Health & Exposoom, Bazdar, Somayeh, Bloemsma, Lizan D., Baalbaki, Nadia, Blankestijn, Jelle M., Cornelissen, Merel E.B., Beijers, Rosanne J.H.C.G., Sondermeijer, Brigitte M., van Wijck, Yolanda, Downward, George S., Maitland-van der Zee, Anke H., and on behalf of the P4O2 Consortium

Published
2024

38. Association between butyrate-producing gut bacteria and the risk of infectious disease hospitalisation : results from two observational, population-based microbiome studies

Author

Kullberg, Robert F.J., Wikki, Irina, Haak, Bastiaan W., Kauko, Anni, Galenkamp, Henrike, Peters-Sengers, Hessel, Butler, Joe M., Havulinna, Aki S., Palmu, Joonatan, McDonald, Daniel, Benchraka, Chouaib, Abdel-Aziz, Mahmoud I., Prins, Maria, Maitland van der Zee, Anke H., van den Born, Bert Jan, Jousilahti, Pekka, de Vos, Willem M., Salomaa, Veikko, Knight, Rob, Lahti, Leo, Nieuwdorp, Max, Niiranen, Teemu, Wiersinga, W.J., Kullberg, Robert F.J., Wikki, Irina, Haak, Bastiaan W., Kauko, Anni, Galenkamp, Henrike, Peters-Sengers, Hessel, Butler, Joe M., Havulinna, Aki S., Palmu, Joonatan, McDonald, Daniel, Benchraka, Chouaib, Abdel-Aziz, Mahmoud I., Prins, Maria, Maitland van der Zee, Anke H., van den Born, Bert Jan, Jousilahti, Pekka, de Vos, Willem M., Salomaa, Veikko, Knight, Rob, Lahti, Leo, Nieuwdorp, Max, Niiranen, Teemu, and Wiersinga, W.J.

Abstract

Background: Microbiota alterations are common in patients hospitalised for severe infections, and preclinical models have shown that anaerobic butyrate-producing gut bacteria protect against systemic infections. However, the relationship between microbiota disruptions and increased susceptibility to severe infections in humans remains unclear. We investigated the relationship between gut microbiota and the risk of future infection-related hospitalisation in two large population-based cohorts. Methods: In this observational microbiome study, gut microbiota were characterised using 16S rRNA gene sequencing in independent population-based cohorts from the Netherlands (HELIUS study; derivation cohort) and Finland (FINRISK 2002 study; validation cohort). HELIUS was conducted in Amsterdam, Netherlands, and included adults (aged 18–70 years at inclusion) who were randomly sampled from the municipality register of Amsterdam. FINRISK 2002 was conducted in six regions in Finland and is a population survey that included a random sample of adults (aged 25–74 years). In both cohorts, participants completed questionnaires, underwent a physical examination, and provided a faecal sample at inclusion (Jan 3, 2013, to Nov 27, 2015, for HELIUS participants and Jan 21 to April 19, 2002, for FINRISK participants. For inclusion in our study, a faecal sample needed to be provided and successfully sequenced, and national registry data needed to be available. Primary predictor variables were microbiota composition, diversity, and relative abundance of butyrate-producing bacteria. Our primary outcome was hospitalisation or mortality due to any infectious disease during 5–7-year follow-up after faecal sample collection, based on national registry data. We examined associations between microbiota and infection risk using microbial ecology and Cox proportional hazards. Findings: We profiled gut microbiota from 10 699 participants (4248 [39·7%] from the derivation cohort and 6451 [60·3%] from th

Published
2024

39. Reframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies

Author

Medische Staf Intensive Care, Infection & Immunity, Shankar-Hari, Manu, Calandra, Thierry, Soares, Miguel P, Bauer, Michael, Wiersinga, W Joost, Prescott, Hallie C, Knight, Julian C, Baillie, Kenneth J, Bos, Lieuwe D J, Derde, Lennie P G, Finfer, Simon, Hotchkiss, Richard S, Marshall, John, Openshaw, Peter J M, Seymour, Christopher W, Venet, Fabienne, Vincent, Jean-Louis, Le Tourneau, Christophe, Maitland-van der Zee, Anke H, McInnes, Iain B, van der Poll, Tom, Medische Staf Intensive Care, Infection & Immunity, Shankar-Hari, Manu, Calandra, Thierry, Soares, Miguel P, Bauer, Michael, Wiersinga, W Joost, Prescott, Hallie C, Knight, Julian C, Baillie, Kenneth J, Bos, Lieuwe D J, Derde, Lennie P G, Finfer, Simon, Hotchkiss, Richard S, Marshall, John, Openshaw, Peter J M, Seymour, Christopher W, Venet, Fabienne, Vincent, Jean-Louis, Le Tourneau, Christophe, Maitland-van der Zee, Anke H, McInnes, Iain B, and van der Poll, Tom

Published
2024

40. The effects of the COVID-19 pandemic on PICU admissions for severe asthma exacerbations: A single-center experience

Author

Planetary Health & Exposoom, Bazdar, Somayeh, van den Berg, Sarah, Rutjes, Niels W, Bloemsma, Lizan D, Downward, George S, De Weger, Letty A, Terheggen-Lagro, Suzanne W J, van Wijck, Yolanda, Maitland van der Zee, Anke H, Kapitein, Berber, Planetary Health & Exposoom, Bazdar, Somayeh, van den Berg, Sarah, Rutjes, Niels W, Bloemsma, Lizan D, Downward, George S, De Weger, Letty A, Terheggen-Lagro, Suzanne W J, van Wijck, Yolanda, Maitland van der Zee, Anke H, and Kapitein, Berber

Published
2024

41. Long COVID exhibits clinically distinct phenotypes at 3–6 months post-SARSCoV-2 infection: results from the P4O2 consortium

Author

IRAS – One Health Chemical, IRAS OH Epidemiology Chemical Agents, on behalf of the P4O2 consortium, Blankestijn, Jelle M., Abdel-Aziz, Mahmoud I., Baalbaki, Nadia, Bazdar, Somayeh, Beekers, Inés, Beijers, Rosanne J.H.C.G., Bloemsma, Lizan D., Cornelissen, Merel E.B., Gach, Debbie, Houweling, Laura, Holverda, Sebastiaan, Jacobs, John J.L., Jonker, Reneé, van der Lee, Ivo, Linders, Paulien M.A., Mohamed Hoesein, Firdaus A.A., Noij, Lieke C.E., Nossent, Esther J., van de Pol, Marianne A., Schaminee, Daphne W., Schols, Annemie M.W.J., Schuurman, Lisanne T., Sondermeijer, Brigitte, Geelhoed, J. J.Miranda, van den Bergh, Joop P., Weersink, Els J.M., de Wit-Van Wijck, Yolanda, Maitland-Van der Zee, Anke H., IRAS – One Health Chemical, IRAS OH Epidemiology Chemical Agents, on behalf of the P4O2 consortium, Blankestijn, Jelle M., Abdel-Aziz, Mahmoud I., Baalbaki, Nadia, Bazdar, Somayeh, Beekers, Inés, Beijers, Rosanne J.H.C.G., Bloemsma, Lizan D., Cornelissen, Merel E.B., Gach, Debbie, Houweling, Laura, Holverda, Sebastiaan, Jacobs, John J.L., Jonker, Reneé, van der Lee, Ivo, Linders, Paulien M.A., Mohamed Hoesein, Firdaus A.A., Noij, Lieke C.E., Nossent, Esther J., van de Pol, Marianne A., Schaminee, Daphne W., Schols, Annemie M.W.J., Schuurman, Lisanne T., Sondermeijer, Brigitte, Geelhoed, J. J.Miranda, van den Bergh, Joop P., Weersink, Els J.M., de Wit-Van Wijck, Yolanda, and Maitland-Van der Zee, Anke H.

Published
2024

42. Fatigue and symptom-based clusters in post COVID-19 patients: a multicentre, prospective, observational cohort study

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Cornelissen, Merel E.B., Bloemsma, Lizan D., Vaes, Anouk W., Baalbaki, Nadia, Deng, Qichen, Beijers, Rosanne J.H.C.G., Noij, Lieke C.E., Houweling, Laura, Bazdar, Somayeh, Spruit, Martijn A., Maitland-van der Zee, Anke H., IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Cornelissen, Merel E.B., Bloemsma, Lizan D., Vaes, Anouk W., Baalbaki, Nadia, Deng, Qichen, Beijers, Rosanne J.H.C.G., Noij, Lieke C.E., Houweling, Laura, Bazdar, Somayeh, Spruit, Martijn A., and Maitland-van der Zee, Anke H.

Published
2024

43. The effects of the COVID-19 pandemic on PICU admissions for severe asthma exacerbations: A single-center experience

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Bazdar, Somayeh, van den Berg, Sarah, Rutjes, Niels W, Bloemsma, Lizan D, Downward, George S, De Weger, Letty A, Terheggen-Lagro, Suzanne W J, van Wijck, Yolanda, Maitland van der Zee, Anke H, Kapitein, Berber, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Bazdar, Somayeh, van den Berg, Sarah, Rutjes, Niels W, Bloemsma, Lizan D, Downward, George S, De Weger, Letty A, Terheggen-Lagro, Suzanne W J, van Wijck, Yolanda, Maitland van der Zee, Anke H, and Kapitein, Berber

Published
2024

44. A severe asthma phenotype of excessive airway Haemophilus influenzae relative abundance associated with sputum neutrophilia.

Author

Versi, Ali, Azim, Adnan, Ivan, Fransiskus Xaverius, Abdel‐Aziz, Mahmoud I, Bates, Stewart, Riley, John, Uddin, Mohib, Zounemat Kermani, Nazanin, Maitland‐Van Der Zee, Anke‐H, Dahlen, Sven‐Eric, Djukanovic, Ratko, Chotirmall, Sanjay H, Howarth, Peter, Adcock, Ian M, and Chung, Kian Fan

Subjects
HAEMOPHILUS influenzae, MORAXELLA catarrhalis, CUTIBACTERIUM acnes, ACTINOBACILLUS, HIERARCHICAL clustering (Cluster analysis)
Abstract

Background: Severe asthma (SA) encompasses several clinical phenotypes with a heterogeneous airway microbiome. We determined the phenotypes associated with a low α‐diversity microbiome. Methods: Metagenomic sequencing was performed on sputum samples from SA participants. A threshold of 2 standard deviations below the mean of α‐diversity of mild‐moderate asthma and healthy control subjects was used to define those with an abnormal abundance threshold as relative dominant species (RDS). Findings: Fifty‐one out of 97 SA samples were classified as RDSs with Haemophilus influenzae RDS being most common (n = 16), followed by Actinobacillus unclassified (n = 10), Veillonella unclassified (n = 9), Haemophilus aegyptius (n = 9), Streptococcus pseudopneumoniae (n = 7), Propionibacterium acnes (n = 5), Moraxella catarrhalis (n = 5) and Tropheryma whipplei (n = 5). Haemophilus influenzae RDS had the highest duration of disease, more exacerbations in previous year and greatest number on daily oral corticosteroids. Hierarchical clustering of RDSs revealed a C2 cluster (n = 9) of highest relative abundance of exclusively Haemophilus influenzae RDSs with longer duration of disease and higher sputum neutrophil counts associated with enrichment pathways of MAPK, NF‐κB, TNF, mTOR and necroptosis, compared to the only other cluster, C1, which consisted of 7 Haemophilus influenzae RDSs out of 42. Sputum transcriptomics of C2 cluster compared to C1 RDSs revealed higher expression of neutrophil extracellular trap pathway (NETosis), IL6‐transignalling signature and neutrophil activation. Conclusion: We describe a Haemophilus influenzae cluster of the highest relative abundance associated with neutrophilic inflammation and NETosis indicating a host response to the bacteria. This phenotype of severe asthma may respond to specific antibiotics. [ABSTRACT FROM AUTHOR]

Published
2024
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45. eNose breath prints as a surrogate biomarker for classifying patients with asthma by atopy

Author

Abdel-Aziz, Mahmoud I., Brinkman, Paul, Vijverberg, Susanne J.H., Neerincx, Anne H., de Vries, Rianne, Dagelet, Yennece W.F., Riley, John H., Hashimoto, Simone, Montuschi, Paolo, Chung, Kian Fan, Djukanovic, Ratko, Fleming, Louise J., Murray, Clare S., Frey, Urs, Bush, Andrew, Singer, Florian, Hedlin, Gunilla, Roberts, Graham, Dahlén, Sven-Erik, Adcock, Ian M., Fowler, Stephen J., Knipping, Karen, Sterk, Peter J., Kraneveld, Aletta D., and Maitland-van der Zee, Anke H.

Published
2020
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49. Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment

Author

Rasmussen, Eva Rye, Hallberg, Pär, Baranova, Ekaterina V., Eriksson, Niclas, Karawajczyk, Malgorzata, Johansson, Caroline, Cavalli, Marco, Maroteau, Cyrielle, Veluchamy, Abirami, Islander, Gunilla, Hugosson, Svante, Terreehorst, Ingrid, Asselbergs, Folkert W., Norling, Pia, Johansson, Hans-Erik, Kohnke, Hugo, Syvänen, Ann-Christine, Siddiqui, Moneeza K., Lang, Chim C., Magnusson, Patrik K. E., Yue, Qun-Ying, Wadelius, Claes, von Buchwald, Christian, Bygum, Anette, Alfirevic, Ana, Maitland-van der Zee, Anke H., Palmer, Colin N. A., and Wadelius, Mia

Published
2020
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50. Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

Author

King, Charlotte, McKenna, Amanda, Farzan, Niloufar, Vijverberg, Susanne J., van der Schee, Marc P., Maitland-van der Zee, Anke H., Arianto, Lambang, Bisgaard, Hans, BØnnelykke, Klaus, Berce, Vojko, PotoČnik, Uros, Repnik, Katja, Carleton, Bruce, Daley, Denise, Chew, Fook Tim, Chiang, Wen Chin, Sio, Yang Yie, Cloutier, Michelle M., Den Dekker, Herman T., Duijts, Liesbeth, de Jongste, Johan C., Dijk, F. Nicole, Flores, Carlos, Hernandez-Pacheco, Natalia, Mukhopadhyay, Somnath, Basu, Kaninika, Tantisira, Kelan G., Verhamme, Katia M., Celedón, Juan C., Forno, Erick, Canino, Glorisa, Francis, Ben, Pirmohamed, Munir, Sinha, Ian, and Hawcutt, Daniel B.

Published
2020
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