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5. Increased breath naphthalene in children with asthma and wheeze of the All Age Asthma Cohort (ALLIANCE)

Author

Shahrokny, Pedram, primary, Maison, Nicole, additional, Riemann, Lennart, additional, Ehrmann, Maximilian, additional, DeLuca, David, additional, Schuchardt, Sven, additional, Thiele, Dominik, additional, Weckmann, Markus, additional, Dittrich, Anna-Maria, additional, Schaub, Bianca, additional, Brinkmann, Folke, additional, Hansen, Gesine, additional, Kopp, Matthias, additional, von Mutius, Erika, additional, Rabe, Klaus, additional, Bahmer, Thomas, additional, Hohlfeld, Jens, additional, Grychtol, Ruth, additional, and Holz, Olaf, additional

Published
2023
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7. Changes in behavior and quality of life in German young children during the COVID-19 pandemic—results from the COVID kids bavaria study

Author

Schillok, Hannah, primary, Coenen, Michaela, additional, Rehfuess, Eva A., additional, Kuhlmann, Pia H., additional, Matl, Stefan, additional, Kindermann, Hannah, additional, Maison, Nicole, additional, Eckert, Jana, additional, von Both, Ulrich, additional, Behrends, Uta, additional, Frühwald, Michael C., additional, Neubert, Antje, additional, Woelfle, Joachim, additional, Melter, Michael, additional, Liese, Johannes, additional, Hübner, Johannes, additional, Klein, Christoph, additional, Kern, Anna, additional, and Jung-Sievers, Caroline, additional

Published
2023
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9. Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE cohort

Author

Grychtol, Ruth, primary, Riemann, Lennart, additional, Gaedcke, Svenja, additional, Liu, Bin, additional, DeLuca, David, additional, Förster, Reinhold, additional, Maison, Nicole, additional, Thiele, Dominik, additional, Jakobs, Nikolas, additional, Bahmer, Thomas, additional, Meyer, Meike, additional, Foth, Svenja, additional, Weber, Stefanie, additional, Rietschel, Ernst, additional, Rabe, Klaus F., additional, Kopp, Matthias V., additional, von Mutius, Erika, additional, Dittrich, Anna-Maria, additional, and Hansen, Gesine, additional

Published
2023
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10. Quality Control of Nitrogen Multiple Breath Washout in a Multicenter Pediatric Asthma Study

Author

Nitsche, Catharina, additional, Frauchiger, Bettina Sarah, additional, Thiele, Dominik, additional, Oestreich, Marc-Alexander, additional, Husstedt, Berrit Liselotte, additional, Grychtol, Ruth Margarethe, additional, Maison, Nicole, additional, Foth, Svenja, additional, Meyer, Meike, additional, Jakobs, Nikolas, additional, Bahmer, Thomas, additional, Hansen, Gesine, additional, von Mutius, Erika, additional, and Kopp, Matthias, additional

Published
2023
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11. T-high asthma phenotypes across life span

Author

Maison, Nicole, Omony, Jimmy, Illi, Sabina, Thiele, Dominik, Skevaki, Chrysanthi, Dittrich, Anna-Maria, Bahmer, Thomas, Rabe, Klaus Friedrich, Weckmann, Markus, Happle, Christine, Schaub, Bianca, Meier, Meike, Foth, Svenja, Rietschel, Ernst, Renz, Harald, Hansen, Gesine, Kopp, Matthias Volkmar, von Mutius, Erika, and Grychtol, Ruth

Subjects
610 Medicine & health
Abstract

RATIONALE In adults, personalised asthma treatment targets patients with T2-high and eosinophilic asthma phenotypes. It is unclear whether such classification is achievable in children. OBJECTIVES To define T2-high asthma with easily accessible biomarkers and compare resulting phenotypes across all ages. METHODS In the multicenter clinical ALL Age Asthma Cohort (ALLIANCE), 1125 participants (n=776 asthmatics, n=349 controls) were recruited and followed for 2���years (1���year in adults). Extensive clinical characterisation (questionnaires, blood differential count, allergy testing, lung function and sputum induction (in adults) was performed at baseline and follow-ups. Interleukin (IL)-4, IL-5 and IL-13 were measured after stimulation of whole blood with LPS or anti-CD3/CD28. MEASUREMENTS AND MAIN RESULTS Based on blood eosinophil counts and allergen-specific serum IgE antibodies (sIgE), patients were categorised into four mutually exclusive phenotypes: "Atopy-only", "Eosinophils-only", "T2-high" (eosinophilia+atopy) and "T2-low" (neither eosinophilia nor atopy). The T2-high phenotype was found across all ages, even in very young children in whom it persisted to a large degree even after 2���years of follow-up. T2-high asthma in adults was associated with childhood onset suggesting early origins of this asthma phenotype. In both children and adults, the T2-high phenotype was characterised by excessive production of specific IgE to allergens (p

Published
2022
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12. T2-high asthma phenotypes across lifespan

Author

Maison, Nicole, Omony, Jimmy, Illi, Sabina, Thiele, Dominik, Skevaki, Chrysanthi, Dittrich, Anna -Maria, Bahmer, Thomas, Rabe, Klaus Friedrich, Weckmann, Markus, Happle, Christine, Schaub, Bianca, Meyer, Meike, Foth, Svenja, Rietschel, Ernst, Renz, Harald, Hansen, Gesine, Kopp, Matthias Volkmar, von Mutius, Erika, Grychtol, Ruth, Maison, Nicole, Omony, Jimmy, Illi, Sabina, Thiele, Dominik, Skevaki, Chrysanthi, Dittrich, Anna -Maria, Bahmer, Thomas, Rabe, Klaus Friedrich, Weckmann, Markus, Happle, Christine, Schaub, Bianca, Meyer, Meike, Foth, Svenja, Rietschel, Ernst, Renz, Harald, Hansen, Gesine, Kopp, Matthias Volkmar, von Mutius, Erika, and Grychtol, Ruth

Abstract

Rationale In adults, personalised asthma treatment targets patients with type 2 (T2)-high and eosinophilic asthma phenotypes. It is unclear whether such classification is achievable in children. Objectives To define T2-high asthma with easily accessible biomarkers and compare resulting phenotypes across all ages. Methods In the multicentre clinical All Age Asthma Cohort (ALLIANCE), 1125 participants (n=776 asthmatics, n=349 controls) were recruited and followed for 2 years (1 year in adults). Extensive clinical characterisation (questionnaires, blood differential count, allergy testing, lung function and sputum induction (in adults)) was performed at baseline and follow-ups. Interleukin (IL)-4, IL-5 and IL-13 were measured after stimulation of whole blood with lipopolysaccharide (LPS) or anti-CD3/CD28.Measurements and main results Based on blood eosinophil counts and allergen-specific serum IgE antibodies, patients were categorised into four mutually exclusive phenotypes: atopy-only, eosinophils-only, T2-high (eosinophilia + atopy) and T2-low (neither eosinophilia nor atopy). The T2-high phenotype was found across all ages, even in very young children in whom it persisted to a large degree even after 2 years of follow-up. T2-high asthma in adults was associated with childhood onset, suggesting early origins of this asthma phenotype. In both children and adults, the T2-high phenotype was characterised by excessive production of specific IgE to allergens (p<0.0001) and, from school age onwards, by increased production of IL-5 after anti-CD3/CD28 stimulation of whole blood. Conclusions Using easily accessible biomarkers, patients with T2-high asthma can be identified across all ages delineating a distinct phenotype. These patients may benefit from therapy with biologicals even at a younger age.

Published
2022

13. Surveillance of Acute SARS-CoV-2 Infections in Elementary Schools and Daycare Facilities in Bavaria, Germany (09/2020-03/2021)

Author

Kern, Anna, Kuhlmann, Pia H., Matl, Stefan, Ege, Markus, Maison, Nicole, Eckert, Jana, von Both, Ulrich, Behrends, Uta, Anger, Melanie, Frühwald, Michael C., Gerstlauer, Michael, Woelfle, Joachim, Neubert, Antje, Melter, Michael, Liese, Johannes, Goettler, David, Sing, Andreas, Liebl, Bernhard, Hübner, Johannes, and Klein, Christoph

Subjects
Pediatrics, SARS-CoV-2, surveillance, children, elementary school, preschool, PCR, seroprevalence, ddc
Published
2021

14. The role of eosinophils in pediatric and adult asthma

Author

Omony, Jimmy, primary, Grychtol, Ruth, additional, Maison, Nicole, additional, Thiele, Dominik, additional, Chari Jirmo, Adan, additional, Dittrich, Anna-Maria, additional, Bahmer, Thomas, additional, Rabe, Klaus. F, additional, Renz, Harald, additional, Hansen, Gesine, additional, Kopp, Matthias, additional, Schaub, Bianca, additional, Von Mutius, Erika, additional, and Illi, Sabina, additional

Published
2020
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17. Daily adjustment of glucocorticoids by patients with adrenal insufficiency

Author

Schöfl, Christof, Mayr, Bernhard, Maison, Nicole, Beuschlein, Felix, Meyer, Gesine, Badenhoop, Klaus, Kienitz, Tina, Quinkler, Marcus, University of Zurich, and Quinkler, Marcus

Subjects
2712 Endocrinology, Diabetes and Metabolism, 10265 Clinic for Endocrinology and Diabetology, 610 Medicine & health, 1310 Endocrinology
Published
2019

18. Allergen extract‐ and component‐based diagnostics in children of the ALLIANCE asthma cohort.

Author

Skevaki, Chrysanthi, Tafo, Pavel, Eiringhaus, Kathrin, Timmesfeld, Nina, Weckmann, Markus, Happle, Christine, Nelson, Philipp P., Maison, Nicole, Schaub, Bianca, Ricklefs, Isabell, Fuchs, Oliver, von Mutius, Erika, Kopp, Matthias Volkmar, Renz, Harald, Hansen, Gesine, and Dittrich, Anna‐Maria

Subjects
WHEEZE, ALLERGIC conjunctivitis, ALLERGENS, ASTHMA in children, HOUSE dust mites, FOOD allergy, ALLERGIES
Abstract

Background: Current in vitro allergen‐specific IgE (sIgE) detection assays measure IgE against allergen extracts or molecules in a single‐ or multiplex approach. Direct comparisons of the performance of such assays among young children with common presentations of allergic diseases regardless of sensitization status are largely missing. Objectives: The aim of this study was a comparison of the analytical and diagnostic performance for common clinical questions of three commonly used technologies which rely upon different laboratory methodologies among children of the All Age Asthma (ALLIANCE) cohort (clinicaltrials.gov: NCT02496468). Methods: Sera from 106 paediatric study participants (mean age 4 years) were assessed for the presence of sIgE by means of the ImmunoCAP™ sx1 and fx5 mixes, the ImmunoCAP ISAC™ 112 microarray and a Euroline™ panel. Results: Total and negative concordance was high (>82%–>89%), while positive concordance varied considerably (0%–100%) but was also >50% for the most common sensitizations analysed (house dust mite and birch). All three test systems showed good sensitivity and specificity (AUC consistently > 0.7). However, no significant differences with regard to identifying sIgE sensitizations associated with symptoms in children with suspected pollen‐ or dust‐triggered wheeze or presenting with symptoms of allergic rhinoconjunctivitis or food allergy were detected. Extending the number of allergens did not change the similar performance of the three assay systems. Conclusion and Clinical Relevance: Among young children, the three sIgE assays showed good analytical and diagnostic concordance. Our results caution that the identification of larger numbers of sensitizations by more comprehensive multiplex approaches may not improve the clinical utility of sIgE testing in this age group. [ABSTRACT FROM AUTHOR]

Published
2021
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19. Impact of imposed social isolation and use of face masks on asthma course and mental health in pediatric and adult patients with recurrent wheeze and asthma.

Author

Maison, Nicole, Herbrüggen, Heidrun, Schaub, Bianca, Schauberger, Christina, Foth, Svenja, Grychtol, Ruth, Abdo, Mustafa, Watz, Henrik, Nikolaizik, Wilfried, Rabe, Klaus F., Kopp, Matthias V., Hansen, Gesine, von Mutius, Erika, Bahmer, Thomas, Omony, Jimmy, the ALLIANCE study group, Fuchs, Oliver, Roesler, Barbara, Welchering, Nils, and Kohistani-Greif, Naschla

Subjects
*WHEEZE, *ASTHMA, *SOCIAL isolation, *MENTAL health, *SOCIAL impact, *MEDICAL masks
Abstract

Background: There is currently a dramatic increase in the number of COVID-19 cases worldwide, and further drastic restrictions in our daily life will be necessary to contain this pandemic. The implications of restrictive measures like social-distancing and mouth-nose protection on patients with chronic respiratory diseases have hardly been investigated. Methods: Our survey, was conducted within the All Age Asthma Cohort (ALLIANCE), a multicenter longitudinal observational study. We assessed the effects of COVID-19 imposed social isolation and use of facial masks, on asthma course and mental health in patients with asthma and wheezing. Results: We observed a high rate of problems associated with using facemasks and a significant reduction in the use of routine medical care. In addition to unsettling impacts, such as an increase in depression symptoms in adults, an astonishing and pleasing effect was striking: preschool children experienced an improvement in disease condition during the lockdown. This improvement can be attributed to a significant reduction in exposure to viral infections. Conclusion: Long-term observation of this side effect may help improve our understanding of the influence of viral infections on asthma in early childhood. [ABSTRACT FROM AUTHOR]

Published
2021
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22. Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

Author

Fishbein, Lauren, Leshchiner, Ignaty, Walter, Vonn, Danilova, Ludmila, Robertson, A. Gordon, Johnson, Amy R., Lichtenberg, Tara M., Murray, Bradley A., Ghayee, Hans K., Else, Tobias, Ling, Shiyun, Jefferys, Stuart R., de Cubas, Aguirre A., Wenz, Brandon, Korpershoek, Esther, Amelio, Antonio L., Makowski, Liza, Rathmell, W. Kimryn, Gimenez-Roqueplo, Anne Paule, Giordano, Thomas J., Asa, Sylvia L., Tischler, Arthur S., Akbani, Rehan, Ally, Adrian, Amar, Laurence, Arachchi, Harindra, Auchus, Richard J., Auman, J. Todd, Baertsch, Robert, Balasundaram, Miruna, Balu, Saianand, Bartsch, Detlef K., Baudin, Eric, Bauer, Thomas, Beaver, Allison, Benz, Christopher, Beroukhim, Rameen, Beuschlein, Felix, Bodenheimer, Tom, Boice, Lori, Bowen, Jay, Bowlby, Reanne, Brooks, Denise, Carlsen, Rebecca, Carter, Suzie, Cassol, Clarissa A., Cherniack, Andrew D., Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cope, Leslie, Crain, Daniel, Curley, Erin, de Krijger, Ronald R., Demchok, John A., Deutschbein, Timo, Dhalla, Noreen, Dimmock, David, Dinjens, Winand N M, Eng, Charis, Eschbacher, Jennifer, Fassnacht, Martin, Felau, Ina, Feldman, Michael, Ferguson, Martin L., Fiddes, Ian, Frazer, Scott, Gabriel, Stacey B., Gardner, Johanna, Gastier-Foster, Julie M., Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Geurts, Jennifer, Goldman, Mary, Graim, Kiley, Gupta, Manaswi, Haan, David, Hahner, Stefanie, Hantel, Constanze, Haussler, David, Hayes, D. Neil, Heiman, David I., Hoadley, Katherine A., Holt, Robert A., Hoyle, Alan P., Huang, Mei, Hunt, Bryan, Hutter, Carolyn M., Jones, Steven J M, Jones, Corbin D., Kasaian, Katayoon, Kebebew, Electron, Kim, Jaegil, Kimes, Patrick, Knijnenburg, Theo, Lander, Eric, Lawrence, Michael S., Lechan, Ronald, Lee, Darlene, Leraas, Kristen M., Lerario, Antonio, Lin, Pei, Liu, Jia, LiVolsi, Virginia A., Lolla, Laxmi, Lotan, Yair, Lu, Yiling, Ma, Yussanne, Maison, Nicole, Mallery, David, Mannelli, Massimo, Marquard, Jessica, Marra, Marco A., Matthew, Thomas, Mayo, Michael, Méatchi, Tchao, Meng, Shaowu, Merino, Maria J., Mete, Ozgur, Meyerson, Matthew, Mieczkowski, Piotr A., Mills, Gordon B., Moore, Richard A., Morozova, Olena, Morris, Scott, Mose, Lisle E., Mungall, Andrew J., Naresh, Rashi, Nathanson, Katherine L., Newton, Yulia, Ng, Sam, Ni, Ying, Noble, Michael S., Nwariaku, Fiemu, Pacak, Karel, Parker, Joel S., Paul, Evan, Penny, Robert, Perou, Charles M., Perou, Amy H., Pihl, Todd, Powers, James, Rabaglia, Jennifer, Radenbaugh, Amie, Ramirez, Nilsa C., Rao, Arjun, Riester, Anna, Roach, Jeffrey, Sadeghi, Sara, Saksena, Gordon, Salama, Sofie, Saller, Charles, Sandusky, George, Sbiera, Silviu, Schein, Jacqueline E., Schumacher, Steven E., Shelton, Candace, Shelton, Troy, Sheth, Margi, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Simons, Janae V., Sipahimalani, Payal, Skelly, Tara, Sofia, Heidi J., Sokolov, Artem, Soloway, Matthew G., Sougnez, Carrie, Stuart, Josh, Sun, Charlie, Swatloski, Teresa, Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Tarvin, Katherine, Thiessen, Nina, Thorne, Leigh B., Timmers, Henri J., Tse, Kane, Uzunangelov, Vlado, van Berkel, Anouk, Veluvolu, Umadevi, Vicha, Ales, Voet, Doug, Waldmann, Jens, Wan, Yunhu, Wang, Zhining, Wang, Tracy S., Weaver, Joellen, Weinstein, John N., Weismann, Dirk, Wilkerson, Matthew D., Wise, Lisa, Wong, Tina, Wong, Christopher, Wu, Ye, Yang, Liming, Zelinka, Tomas, Zenklusen, Jean C., Zhang, Jiashan (Julia), Zhang, Wei, Zhu, Jingchun, Zinzindohoué, Franck, Zmuda, Erik, Fishbein, Lauren, Leshchiner, Ignaty, Walter, Vonn, Danilova, Ludmila, Robertson, A. Gordon, Johnson, Amy R., Lichtenberg, Tara M., Murray, Bradley A., Ghayee, Hans K., Else, Tobias, Ling, Shiyun, Jefferys, Stuart R., de Cubas, Aguirre A., Wenz, Brandon, Korpershoek, Esther, Amelio, Antonio L., Makowski, Liza, Rathmell, W. Kimryn, Gimenez-Roqueplo, Anne Paule, Giordano, Thomas J., Asa, Sylvia L., Tischler, Arthur S., Akbani, Rehan, Ally, Adrian, Amar, Laurence, Arachchi, Harindra, Auchus, Richard J., Auman, J. Todd, Baertsch, Robert, Balasundaram, Miruna, Balu, Saianand, Bartsch, Detlef K., Baudin, Eric, Bauer, Thomas, Beaver, Allison, Benz, Christopher, Beroukhim, Rameen, Beuschlein, Felix, Bodenheimer, Tom, Boice, Lori, Bowen, Jay, Bowlby, Reanne, Brooks, Denise, Carlsen, Rebecca, Carter, Suzie, Cassol, Clarissa A., Cherniack, Andrew D., Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cope, Leslie, Crain, Daniel, Curley, Erin, de Krijger, Ronald R., Demchok, John A., Deutschbein, Timo, Dhalla, Noreen, Dimmock, David, Dinjens, Winand N M, Eng, Charis, Eschbacher, Jennifer, Fassnacht, Martin, Felau, Ina, Feldman, Michael, Ferguson, Martin L., Fiddes, Ian, Frazer, Scott, Gabriel, Stacey B., Gardner, Johanna, Gastier-Foster, Julie M., Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Geurts, Jennifer, Goldman, Mary, Graim, Kiley, Gupta, Manaswi, Haan, David, Hahner, Stefanie, Hantel, Constanze, Haussler, David, Hayes, D. Neil, Heiman, David I., Hoadley, Katherine A., Holt, Robert A., Hoyle, Alan P., Huang, Mei, Hunt, Bryan, Hutter, Carolyn M., Jones, Steven J M, Jones, Corbin D., Kasaian, Katayoon, Kebebew, Electron, Kim, Jaegil, Kimes, Patrick, Knijnenburg, Theo, Lander, Eric, Lawrence, Michael S., Lechan, Ronald, Lee, Darlene, Leraas, Kristen M., Lerario, Antonio, Lin, Pei, Liu, Jia, LiVolsi, Virginia A., Lolla, Laxmi, Lotan, Yair, Lu, Yiling, Ma, Yussanne, Maison, Nicole, Mallery, David, Mannelli, Massimo, Marquard, Jessica, Marra, Marco A., Matthew, Thomas, Mayo, Michael, Méatchi, Tchao, Meng, Shaowu, Merino, Maria J., Mete, Ozgur, Meyerson, Matthew, Mieczkowski, Piotr A., Mills, Gordon B., Moore, Richard A., Morozova, Olena, Morris, Scott, Mose, Lisle E., Mungall, Andrew J., Naresh, Rashi, Nathanson, Katherine L., Newton, Yulia, Ng, Sam, Ni, Ying, Noble, Michael S., Nwariaku, Fiemu, Pacak, Karel, Parker, Joel S., Paul, Evan, Penny, Robert, Perou, Charles M., Perou, Amy H., Pihl, Todd, Powers, James, Rabaglia, Jennifer, Radenbaugh, Amie, Ramirez, Nilsa C., Rao, Arjun, Riester, Anna, Roach, Jeffrey, Sadeghi, Sara, Saksena, Gordon, Salama, Sofie, Saller, Charles, Sandusky, George, Sbiera, Silviu, Schein, Jacqueline E., Schumacher, Steven E., Shelton, Candace, Shelton, Troy, Sheth, Margi, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Simons, Janae V., Sipahimalani, Payal, Skelly, Tara, Sofia, Heidi J., Sokolov, Artem, Soloway, Matthew G., Sougnez, Carrie, Stuart, Josh, Sun, Charlie, Swatloski, Teresa, Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Tarvin, Katherine, Thiessen, Nina, Thorne, Leigh B., Timmers, Henri J., Tse, Kane, Uzunangelov, Vlado, van Berkel, Anouk, Veluvolu, Umadevi, Vicha, Ales, Voet, Doug, Waldmann, Jens, Wan, Yunhu, Wang, Zhining, Wang, Tracy S., Weaver, Joellen, Weinstein, John N., Weismann, Dirk, Wilkerson, Matthew D., Wise, Lisa, Wong, Tina, Wong, Christopher, Wu, Ye, Yang, Liming, Zelinka, Tomas, Zenklusen, Jean C., Zhang, Jiashan (Julia), Zhang, Wei, Zhu, Jingchun, Zinzindohoué, Franck, and Zmuda, Erik

Published
2017

23. Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

Author

Pathologie Pathologen staf, Onderzoeksgroep 6, Fishbein, Lauren, Leshchiner, Ignaty, Walter, Vonn, Danilova, Ludmila, Robertson, A. Gordon, Johnson, Amy R., Lichtenberg, Tara M., Murray, Bradley A., Ghayee, Hans K., Else, Tobias, Ling, Shiyun, Jefferys, Stuart R., de Cubas, Aguirre A., Wenz, Brandon, Korpershoek, Esther, Amelio, Antonio L., Makowski, Liza, Rathmell, W. Kimryn, Gimenez-Roqueplo, Anne Paule, Giordano, Thomas J., Asa, Sylvia L., Tischler, Arthur S., Akbani, Rehan, Ally, Adrian, Amar, Laurence, Arachchi, Harindra, Auchus, Richard J., Auman, J. Todd, Baertsch, Robert, Balasundaram, Miruna, Balu, Saianand, Bartsch, Detlef K., Baudin, Eric, Bauer, Thomas, Beaver, Allison, Benz, Christopher, Beroukhim, Rameen, Beuschlein, Felix, Bodenheimer, Tom, Boice, Lori, Bowen, Jay, Bowlby, Reanne, Brooks, Denise, Carlsen, Rebecca, Carter, Suzie, Cassol, Clarissa A., Cherniack, Andrew D., Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cope, Leslie, Crain, Daniel, Curley, Erin, de Krijger, Ronald R., Demchok, John A., Deutschbein, Timo, Dhalla, Noreen, Dimmock, David, Dinjens, Winand N M, Eng, Charis, Eschbacher, Jennifer, Fassnacht, Martin, Felau, Ina, Feldman, Michael, Ferguson, Martin L., Fiddes, Ian, Frazer, Scott, Gabriel, Stacey B., Gardner, Johanna, Gastier-Foster, Julie M., Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Geurts, Jennifer, Goldman, Mary, Graim, Kiley, Gupta, Manaswi, Haan, David, Hahner, Stefanie, Hantel, Constanze, Haussler, David, Hayes, D. Neil, Heiman, David I., Hoadley, Katherine A., Holt, Robert A., Hoyle, Alan P., Huang, Mei, Hunt, Bryan, Hutter, Carolyn M., Jones, Steven J M, Jones, Corbin D., Kasaian, Katayoon, Kebebew, Electron, Kim, Jaegil, Kimes, Patrick, Knijnenburg, Theo, Lander, Eric, Lawrence, Michael S., Lechan, Ronald, Lee, Darlene, Leraas, Kristen M., Lerario, Antonio, Lin, Pei, Liu, Jia, LiVolsi, Virginia A., Lolla, Laxmi, Lotan, Yair, Lu, Yiling, Ma, Yussanne, Maison, Nicole, Mallery, David, Mannelli, Massimo, Marquard, Jessica, Marra, Marco A., Matthew, Thomas, Mayo, Michael, Méatchi, Tchao, Meng, Shaowu, Merino, Maria J., Mete, Ozgur, Meyerson, Matthew, Mieczkowski, Piotr A., Mills, Gordon B., Moore, Richard A., Morozova, Olena, Morris, Scott, Mose, Lisle E., Mungall, Andrew J., Naresh, Rashi, Nathanson, Katherine L., Newton, Yulia, Ng, Sam, Ni, Ying, Noble, Michael S., Nwariaku, Fiemu, Pacak, Karel, Parker, Joel S., Paul, Evan, Penny, Robert, Perou, Charles M., Perou, Amy H., Pihl, Todd, Powers, James, Rabaglia, Jennifer, Radenbaugh, Amie, Ramirez, Nilsa C., Rao, Arjun, Riester, Anna, Roach, Jeffrey, Sadeghi, Sara, Saksena, Gordon, Salama, Sofie, Saller, Charles, Sandusky, George, Sbiera, Silviu, Schein, Jacqueline E., Schumacher, Steven E., Shelton, Candace, Shelton, Troy, Sheth, Margi, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Simons, Janae V., Sipahimalani, Payal, Skelly, Tara, Sofia, Heidi J., Sokolov, Artem, Soloway, Matthew G., Sougnez, Carrie, Stuart, Josh, Sun, Charlie, Swatloski, Teresa, Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Tarvin, Katherine, Thiessen, Nina, Thorne, Leigh B., Timmers, Henri J., Tse, Kane, Uzunangelov, Vlado, van Berkel, Anouk, Veluvolu, Umadevi, Vicha, Ales, Voet, Doug, Waldmann, Jens, Wan, Yunhu, Wang, Zhining, Wang, Tracy S., Weaver, Joellen, Weinstein, John N., Weismann, Dirk, Wilkerson, Matthew D., Wise, Lisa, Wong, Tina, Wong, Christopher, Wu, Ye, Yang, Liming, Zelinka, Tomas, Zenklusen, Jean C., Zhang, Jiashan (Julia), Zhang, Wei, Zhu, Jingchun, Zinzindohoué, Franck, Zmuda, Erik, Pathologie Pathologen staf, Onderzoeksgroep 6, Fishbein, Lauren, Leshchiner, Ignaty, Walter, Vonn, Danilova, Ludmila, Robertson, A. Gordon, Johnson, Amy R., Lichtenberg, Tara M., Murray, Bradley A., Ghayee, Hans K., Else, Tobias, Ling, Shiyun, Jefferys, Stuart R., de Cubas, Aguirre A., Wenz, Brandon, Korpershoek, Esther, Amelio, Antonio L., Makowski, Liza, Rathmell, W. Kimryn, Gimenez-Roqueplo, Anne Paule, Giordano, Thomas J., Asa, Sylvia L., Tischler, Arthur S., Akbani, Rehan, Ally, Adrian, Amar, Laurence, Arachchi, Harindra, Auchus, Richard J., Auman, J. Todd, Baertsch, Robert, Balasundaram, Miruna, Balu, Saianand, Bartsch, Detlef K., Baudin, Eric, Bauer, Thomas, Beaver, Allison, Benz, Christopher, Beroukhim, Rameen, Beuschlein, Felix, Bodenheimer, Tom, Boice, Lori, Bowen, Jay, Bowlby, Reanne, Brooks, Denise, Carlsen, Rebecca, Carter, Suzie, Cassol, Clarissa A., Cherniack, Andrew D., Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cope, Leslie, Crain, Daniel, Curley, Erin, de Krijger, Ronald R., Demchok, John A., Deutschbein, Timo, Dhalla, Noreen, Dimmock, David, Dinjens, Winand N M, Eng, Charis, Eschbacher, Jennifer, Fassnacht, Martin, Felau, Ina, Feldman, Michael, Ferguson, Martin L., Fiddes, Ian, Frazer, Scott, Gabriel, Stacey B., Gardner, Johanna, Gastier-Foster, Julie M., Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Geurts, Jennifer, Goldman, Mary, Graim, Kiley, Gupta, Manaswi, Haan, David, Hahner, Stefanie, Hantel, Constanze, Haussler, David, Hayes, D. Neil, Heiman, David I., Hoadley, Katherine A., Holt, Robert A., Hoyle, Alan P., Huang, Mei, Hunt, Bryan, Hutter, Carolyn M., Jones, Steven J M, Jones, Corbin D., Kasaian, Katayoon, Kebebew, Electron, Kim, Jaegil, Kimes, Patrick, Knijnenburg, Theo, Lander, Eric, Lawrence, Michael S., Lechan, Ronald, Lee, Darlene, Leraas, Kristen M., Lerario, Antonio, Lin, Pei, Liu, Jia, LiVolsi, Virginia A., Lolla, Laxmi, Lotan, Yair, Lu, Yiling, Ma, Yussanne, Maison, Nicole, Mallery, David, Mannelli, Massimo, Marquard, Jessica, Marra, Marco A., Matthew, Thomas, Mayo, Michael, Méatchi, Tchao, Meng, Shaowu, Merino, Maria J., Mete, Ozgur, Meyerson, Matthew, Mieczkowski, Piotr A., Mills, Gordon B., Moore, Richard A., Morozova, Olena, Morris, Scott, Mose, Lisle E., Mungall, Andrew J., Naresh, Rashi, Nathanson, Katherine L., Newton, Yulia, Ng, Sam, Ni, Ying, Noble, Michael S., Nwariaku, Fiemu, Pacak, Karel, Parker, Joel S., Paul, Evan, Penny, Robert, Perou, Charles M., Perou, Amy H., Pihl, Todd, Powers, James, Rabaglia, Jennifer, Radenbaugh, Amie, Ramirez, Nilsa C., Rao, Arjun, Riester, Anna, Roach, Jeffrey, Sadeghi, Sara, Saksena, Gordon, Salama, Sofie, Saller, Charles, Sandusky, George, Sbiera, Silviu, Schein, Jacqueline E., Schumacher, Steven E., Shelton, Candace, Shelton, Troy, Sheth, Margi, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Simons, Janae V., Sipahimalani, Payal, Skelly, Tara, Sofia, Heidi J., Sokolov, Artem, Soloway, Matthew G., Sougnez, Carrie, Stuart, Josh, Sun, Charlie, Swatloski, Teresa, Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Tarvin, Katherine, Thiessen, Nina, Thorne, Leigh B., Timmers, Henri J., Tse, Kane, Uzunangelov, Vlado, van Berkel, Anouk, Veluvolu, Umadevi, Vicha, Ales, Voet, Doug, Waldmann, Jens, Wan, Yunhu, Wang, Zhining, Wang, Tracy S., Weaver, Joellen, Weinstein, John N., Weismann, Dirk, Wilkerson, Matthew D., Wise, Lisa, Wong, Tina, Wong, Christopher, Wu, Ye, Yang, Liming, Zelinka, Tomas, Zenklusen, Jean C., Zhang, Jiashan (Julia), Zhang, Wei, Zhu, Jingchun, Zinzindohoué, Franck, and Zmuda, Erik

Published
2017

24. Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

Author

Fishbein, Lauren, primary, Leshchiner, Ignaty, additional, Walter, Vonn, additional, Danilova, Ludmila, additional, Robertson, A. Gordon, additional, Johnson, Amy R., additional, Lichtenberg, Tara M., additional, Murray, Bradley A., additional, Ghayee, Hans K., additional, Else, Tobias, additional, Ling, Shiyun, additional, Jefferys, Stuart R., additional, de Cubas, Aguirre A., additional, Wenz, Brandon, additional, Korpershoek, Esther, additional, Amelio, Antonio L., additional, Makowski, Liza, additional, Rathmell, W. Kimryn, additional, Gimenez-Roqueplo, Anne-Paule, additional, Giordano, Thomas J., additional, Asa, Sylvia L., additional, Tischler, Arthur S., additional, Pacak, Karel, additional, Nathanson, Katherine L., additional, Wilkerson, Matthew D., additional, Akbani, Rehan, additional, Ally, Adrian, additional, Amar, Laurence, additional, Arachchi, Harindra, additional, Auchus, Richard J., additional, Auman, J. Todd, additional, Baertsch, Robert, additional, Balasundaram, Miruna, additional, Balu, Saianand, additional, Bartsch, Detlef K., additional, Baudin, Eric, additional, Bauer, Thomas, additional, Beaver, Allison, additional, Benz, Christopher, additional, Beroukhim, Rameen, additional, Beuschlein, Felix, additional, Bodenheimer, Tom, additional, Boice, Lori, additional, Bowen, Jay, additional, Bowlby, Reanne, additional, Brooks, Denise, additional, Carlsen, Rebecca, additional, Carter, Suzie, additional, Cassol, Clarissa A., additional, Cherniack, Andrew D., additional, Chin, Lynda, additional, Cho, Juok, additional, Chuah, Eric, additional, Chudamani, Sudha, additional, Cope, Leslie, additional, Crain, Daniel, additional, Curley, Erin, additional, de Krijger, Ronald R., additional, Demchok, John A., additional, Deutschbein, Timo, additional, Dhalla, Noreen, additional, Dimmock, David, additional, Dinjens, Winand N.M., additional, Eng, Charis, additional, Eschbacher, Jennifer, additional, Fassnacht, Martin, additional, Felau, Ina, additional, Feldman, Michael, additional, Ferguson, Martin L., additional, Fiddes, Ian, additional, Fishbein, Lauren, additional, Frazer, Scott, additional, Gabriel, Stacey B., additional, Gardner, Johanna, additional, Gastier-Foster, Julie M., additional, Gehlenborg, Nils, additional, Gerken, Mark, additional, Getz, Gad, additional, Geurts, Jennifer, additional, Goldman, Mary, additional, Graim, Kiley, additional, Gupta, Manaswi, additional, Haan, David, additional, Hahner, Stefanie, additional, Hantel, Constanze, additional, Haussler, David, additional, Hayes, D. Neil, additional, Heiman, David I., additional, Hoadley, Katherine A., additional, Holt, Robert A., additional, Hoyle, Alan P., additional, Huang, Mei, additional, Hunt, Bryan, additional, Hutter, Carolyn M., additional, Jones, Steven J.M., additional, Jones, Corbin D., additional, Kasaian, Katayoon, additional, Kebebew, Electron, additional, Kim, Jaegil, additional, Kimes, Patrick, additional, Knijnenburg, Theo, additional, Lander, Eric, additional, Lawrence, Michael S., additional, Lechan, Ronald, additional, Lee, Darlene, additional, Leraas, Kristen M., additional, Lerario, Antonio, additional, Lin, Pei, additional, Liu, Jia, additional, LiVolsi, Virginia A., additional, Lolla, Laxmi, additional, Lotan, Yair, additional, Lu, Yiling, additional, Ma, Yussanne, additional, Maison, Nicole, additional, Mallery, David, additional, Mannelli, Massimo, additional, Marquard, Jessica, additional, Marra, Marco A., additional, Matthew, Thomas, additional, Mayo, Michael, additional, Méatchi, Tchao, additional, Meng, Shaowu, additional, Merino, Maria J., additional, Mete, Ozgur, additional, Meyerson, Matthew, additional, Mieczkowski, Piotr A., additional, Mills, Gordon B., additional, Moore, Richard A., additional, Morozova, Olena, additional, Morris, Scott, additional, Mose, Lisle E., additional, Mungall, Andrew J., additional, Naresh, Rashi, additional, Newton, Yulia, additional, Ng, Sam, additional, Ni, Ying, additional, Noble, Michael S., additional, Nwariaku, Fiemu, additional, Parker, Joel S., additional, Paul, Evan, additional, Penny, Robert, additional, Perou, Charles M., additional, Perou, Amy H., additional, Pihl, Todd, additional, Powers, James, additional, Rabaglia, Jennifer, additional, Radenbaugh, Amie, additional, Ramirez, Nilsa C., additional, Rao, Arjun, additional, Riester, Anna, additional, Roach, Jeffrey, additional, Sadeghi, Sara, additional, Saksena, Gordon, additional, Salama, Sofie, additional, Saller, Charles, additional, Sandusky, George, additional, Sbiera, Silviu, additional, Schein, Jacqueline E., additional, Schumacher, Steven E., additional, Shelton, Candace, additional, Shelton, Troy, additional, Sheth, Margi, additional, Shi, Yan, additional, Shih, Juliann, additional, Shmulevich, Ilya, additional, Simons, Janae V., additional, Sipahimalani, Payal, additional, Skelly, Tara, additional, Sofia, Heidi J., additional, Sokolov, Artem, additional, Soloway, Matthew G., additional, Sougnez, Carrie, additional, Stuart, Josh, additional, Sun, Charlie, additional, Swatloski, Teresa, additional, Tam, Angela, additional, Tan, Donghui, additional, Tarnuzzer, Roy, additional, Tarvin, Katherine, additional, Thiessen, Nina, additional, Thorne, Leigh B., additional, Timmers, Henri J., additional, Tse, Kane, additional, Uzunangelov, Vlado, additional, van Berkel, Anouk, additional, Veluvolu, Umadevi, additional, Vicha, Ales, additional, Voet, Doug, additional, Waldmann, Jens, additional, Wan, Yunhu, additional, Wang, Zhining, additional, Wang, Tracy S., additional, Weaver, Joellen, additional, Weinstein, John N., additional, Weismann, Dirk, additional, Wise, Lisa, additional, Wong, Tina, additional, Wong, Christopher, additional, Wu, Ye, additional, Yang, Liming, additional, Zelinka, Tomas, additional, Zenklusen, Jean C., additional, Zhang, Jiashan (Julia), additional, Zhang, Wei, additional, Zhu, Jingchun, additional, Zinzindohoué, Franck, additional, and Zmuda, Erik, additional

Published
2017
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26. Somatic RET mutation in a patient with pigmented adrenal pheochromocytoma

Author

Pathologie Pathologen staf, Maison, Nicole, Korpershoek, Esther, Eisenhofer, Graeme, Robledo, Mercedes, de Krijger, Ronald, Beuschlein, Felix, Pathologie Pathologen staf, Maison, Nicole, Korpershoek, Esther, Eisenhofer, Graeme, Robledo, Mercedes, de Krijger, Ronald, and Beuschlein, Felix

Published
2016

28. Fasting hypoglycemia is associated with disease progression in presymptomatic early stage type 1 diabetes.

Author

Heinrich, Melanie, Maison, Nicole, Achenbach, Peter, Assfalg, Robin, Braig, Sonja, Böcker, Dominik, Dunstheimer, Desiree, Ermer, Uwe, Gavazzeni, Antonia, Gerstl, Eva‐Maria, Hummel, Sandra, Kick, Kerstin, Müller, Herbert, Nellen‐Hellmuth, Nicole, Ockert, Christian, Sindichakis, Marina, Tretter, Stefanie, Warncke, Katharina, Ziegler, Anette‐Gabriele, and Beyerlein, Andreas

Subjects
*TYPE 1 diabetes, *AUTOANTIBODIES, *BIOMARKERS, *BLOOD sugar, *FASTING, *GLUCOSE tolerance tests, *HYPOGLYCEMIA, *SYMPTOMS, *DISEASE prevalence, *DISEASE progression, *CHILDREN, *DIAGNOSIS
Abstract

Objective: In children with presymptomatic type 1 diabetes, intermittent hyperglycemia and rising hemoglobin A1c levels are a known signal of progression toward insulin‐dependency. Episodes of hypoglycemia, however, have also been reported in one published case. We investigated the prevalence of hypoglycemia and its association with disease progression in children with presymptomatic type 1 diabetes. Methods: We compared the frequency of hypoglycemic fasting blood glucose levels (<60 mg/dL) in 48 autoantibody negative and 167 multiple β‐cell autoantibody positive children aged 2 to 5 years. We classified the autoantibody positive children into three categories based on their glucose levels in fasting state (hypoglycemic [<60 mg/dL], normoglycemic [60‐99 mg/dL] or hyperglycemic [≥100 mg/dL]). We then compared the glucose levels under challenge during oral glucose tolerance tests (OGTTs) between the three categories. Results: In the autoantibody positive children, 5.1% of the fasting samples were hypoglycemic, while in the autoantibody negative children no hypoglycemia was observed. Hypoglycemia occurred more often in autoantibody positive children who had already entered stage 2 or stage 3 of type 1 diabetes than in stage 1 patients (P = 0.02). Children who had hypoglycemic compared to normoglycemic fasting blood glucose values had higher 120‐minute blood glucose values under OGTT challenge, and a higher rate of pathological OGTTs (P = 0.04). Conclusions: Fasting hypoglycemia seems to be an indicator of disease progression in presymptomatic type 1 diabetes and may therefore represent a novel marker for the identification of children who should be monitored more closely for progression toward insulin‐dependent type 1 diabetes. [ABSTRACT FROM AUTHOR]

Published
2018
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30. Epigenetic training of human bronchial epithelium cells by repeated rhinovirus infections.

Author

Risha, Marua Abu, Reddy, Karosham D., Nemani, Sai Sneha Priya, Jakwerth, Constanze, Schmidt‐Weber, Carsten, Bahmer, Thomas, Hansen, Gesine, Mutius, Erika, Rabe, Klaus F., Dittrich, Anna‐Maria, Grychtol, Ruth, Maison, Nicole, Schaub, Bianca, Kopp, Matthias V., Brinkmann, Folke, Meiners, Silke, Jappe, Uta, and Weckmann, Markus

Subjects
*COMMON cold, *GENE expression, *EPITHELIAL cells, *DNA methylation, *VIRUS diseases
Abstract

Background Methods Results Conclusions Humans are subjected to various environmental stressors (bacteria, viruses, pollution) throughout life. As such, an inherent relationship exists between the effect of these exposures with age. The impact of these environmental stressors can manifest through DNA methylation (DNAm). However, whether these epigenetic effects selectively target genes, pathways, and biological regulatory mechanisms remains unclear. Due to the frequency of human rhinovirus (HRV) infections throughout life (particularly in early development), we propose the use of HRV under controlled conditions can model the effect of multiple exposures to environmental stressors.We generated a prediction model by combining transcriptome and DNAm datasets from human epithelial cells after repeated HRV infections. We applied a novel experimental statistical design and method to systematically explore the multifaceted experimental space (number of infections, multiplicity of infections and duration). Our model included 35 samples, each characterized by the three parameters defining their infection status.Trainable genes were defined by a consistent linear directionality in DNAm and gene expression changes with successive infections. We identified 77 trainable genes which could be further explored in future studies. The identified methylation sites were tracked within a pediatric cohort to determine the relative changes in candidate‐trained sites with disease status and age.Repeated viral infections induce an immune training response in bronchial epithelial cells. Training‐sensitive DNAm sites indicate alternate divergent associations in asthma compared to healthy individuals. Our novel model presents a robust tool for identifying trainable genes, providing a foundation for future studies. [ABSTRACT FROM AUTHOR]

Published
2024
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31. IgA + memory B-cells are significantly increased in patients with asthma and small airway dysfunction.

Author

Habener A, Grychtol R, Gaedcke S, DeLuca D, Dittrich AM, Happle C, Abdo M, Watz H, Pedersen F, König IR, Thiele D, Kopp MV, von Mutius E, Bahmer T, Rabe KF, Meyer-Bahlburg A, Hansen G, Fuchs O, Roesler B, Welchering N, Kohistani-Greif N, Kurz J, Landgraf-Rauf K, Laubhahn K, Maison N, Liebl C, Schaub B, Ege M, Illi S, Hose A, Zeitlmann E, Berbig M, Marzi C, Schauberger C, Zissler U, Schmidt-Weber C, Ricklefs I, Diekmann G, Liboschik L, Voigt G, Sultansei L, Weckmann M, Nissen G, Kirsten AM, Waschki B, Herzmann C, Biller H, Gaede KI, Bovermann X, Steinmetz A, Husstedt BL, Nitsche C, Veith V, Szewczyk M, Brinkmann F, Malik A, Schwerk N, Dopfer C, Price M, Jirmo AC, Liu B, Calveron MR, Weber S, Foth S, Skevaki C, Renz H, Meyer M, Schildberg T, Rietschel E, van Koningsbruggen-Rietschel S, and Alcazar M

Subjects
Adult, Humans, Spirometry, Oscillometry, Respiratory System, Immunoglobulin A, Asthma
Abstract

Background: Comprehensive studies investigated the role of T-cells in asthma which led to personalised treatment options targeting severe eosinophilic asthma. However, little is known about the contribution of B-cells to this chronic inflammatory disease. In this study we investigated the contribution of various B-cell populations to specific clinical features in asthma., Methods: In the All Age Asthma Cohort (ALLIANCE), a subgroup of 154 adult asthma patients and 28 healthy controls were included for B-cell characterisation by flow cytometry. Questionnaires, lung function measurements, blood differential counts and allergy testing of participants were analysed together with comprehensive data on B-cells using association studies and multivariate linear models., Results: Patients with severe asthma showed decreased immature B-cell populations while memory B-cells were significantly increased compared with both mild-moderate asthma patients and healthy controls. Furthermore, increased frequencies of IgA + memory B-cells were associated with impaired lung function and specifically with parameters indicative for augmented resistance in the peripheral airways. Accordingly, asthma patients with small airway dysfunction (SAD) defined by impulse oscillometry showed increased frequencies of IgA + memory B-cells, particularly in patients with mild-moderate asthma. Additionally, IgA + memory B-cells significantly correlated with clinical features of SAD such as exacerbations., Conclusions: With this study we demonstrate for the first time a significant association of increased IgA + memory B-cells with asthma and SAD, pointing towards future options for B-cell-directed strategies in preventing and treating asthma., Competing Interests: Conflict of interest: C. Happle reports grants from Novartis and Pari, outside the submitted work. M.V. Kopp reports grants from Allergopharma GmbH and Vertex GmbH; honoraria for lectures from Allergopharma GmbH, Sanofi GmbH, Infectopharm GmbH, Vertex GmbH and Leti GmbH; advisory board membership at Allergopharma GmbH and Sanofi GmbH; outside the submitted work. E. von Mutius reports royalties from Elsevier GmbH, Georg Thieme Verlag, Springer-Verlag GmbH and Elsevier Ltd; consulting fees from the Chinese University of Hong Kong, European Commission, HiPP GmbH & Co KG and AstraZeneca; lecture honoraria from Massachusetts Medical Society, Springer-Verlag GmbH, Elsevier Ltd, Boehringer Ingelheim International GmbH, European Respiratory Society, Universiteit Utrecht – Faculteit Diergeneeskunde, Universität Salzburg, Springer Medizin Verlag GmbH, Japanese Society of Pediatric Allergy and Clinical Immunology (JSPACI), Klinikum Rechts der Isar, University of Colorado, Paul-Martini-Stiftung and Imperial College London; travel support from Verein zur Förderung der Pneumologie am Krankenhaus Großhansdorf eV, Pneumologie Développement, Mondial Congress & Events GmbH & Co. KG, American Academy of Allergy, Asthma & Immunology, Imperial College London, Margaux Orange, Volkswagen Stiftung, Boehringer Ingelheim International GmbH, European Respiratory Society, Universiteit Utrecht – Faculteit Diergeneeskunde, Österreichische Gesellschaft für Allergologie und Immunologie, Massachusetts Medical Society, OM Pharma SA, Hanson Wade Ltd, iKOMM GmbH, DSI Dansk Borneastma Center, American Thoracic Society, HiPP GmbH & Co. KG and Universiteit Utrecht – Faculteit Bètawetenschappen; outside the submitted work. In addition, E. von Mutius has patent LU101064 (Barn dust extract for the prevention and treatment of diseases) pending, royalties paid to ProtectImmun for patent EP2361632 (Specific environmental bacteria for the protection from and/or the treatment of allergic, chronic inflammatory and/or autoimmune disorders, granted on 19 March 2014), and patents EP1411977 (Composition containing bacterial antigens used for the prophylaxis and the treatment of allergic diseases, granted on 18 April 2007), EP1637147 (Stable dust extract for allergy protection, granted on 10 December 2008) and EP1964570 (Pharmaceutical compound to protect against allergies and inflammatory diseases, granted on 21 November 2012) licensed to ProtectImmun. In addition, E. von Mutius is a member of the EXPANSE (funded by European Commission) Scientific Advisory Board, member of the BEAMS External Scientific Advisory Board (ESAB), member of the Editorial Board of the Journal of Allergy and Clinical Immunology: In Practice, member of the Scientific Advisory Board of the Children's Respiratory and Environmental Workgroup (CREW), member of the International Scientific and Societal Advisory Board (ISSAB) of Utrecht Life Sciences (ULS), University of Utrecht, member of the External Review Panel of the Faculty of Veterinary Science, University of Utrecht, member of the Selection Committee for the Gottfried Wilhelm Leibniz Programme (DFG), member of the International Advisory Board of the Asthma UK Centre for Applied Research (AUKCAR), member of the International Advisory Board of The Lancet Respiratory Medicine, and member of the Scientific Advisory Board of the CHILD (Canadian Healthy Infant Longitudinal Development) study, McMaster University, Hamilton, Canada. T. Bahmer reports grants from Network University Medicine (NUM): National Pandemic Cohort Network (NAPKON); consulting fees and lecture honoraria from AstraZeneca, Novartis, GlaxoSmithKline, Roche and Chiesi; travel support from Chiesi and AstraZeneca; outside the submitted work. K.F. Rabe reports lecture honoraria from AstraZeneca, Boehringer Ingelheim, Chiesi Pharmaceuticals, Novartis, Sanofi Regeneron, GlaxoSmithKline, Berlin-Chemie and Roche; advisory board membership at AstraZeneca and Sanofi Regeneron; leadership roles with the German Center for Lung Research (DZL), German Chest Society (DGP) and American Thoracic Society; outside the submitted work. A. Meyer-Bahlburg reports lecture honoraria from Pfizer; travel support from CSL Behring; advisory board membership with Pfizer; outside the submitted work. G. Hansen reports consulting fees from Sanofi GmbH; lecture honoraria from MedUpdate and AbbVie; outside the submitted work. All other authors have nothing to disclose., (Copyright ©The authors 2022.)

Published
2022
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32. Surveillance of Acute SARS-CoV-2 Infections in Elementary Schools and Daycare Facilities in Bavaria, Germany (09/2020-03/2021).

Author

Kern A, Kuhlmann PH, Matl S, Ege M, Maison N, Eckert J, von Both U, Behrends U, Anger M, Frühwald MC, Gerstlauer M, Woelfle J, Neubert A, Melter M, Liese J, Goettler D, Sing A, Liebl B, Hübner J, and Klein C

Abstract

Introduction: Here we report our results of a multi-center, open cohort study ("COVID-Kids-Bavaria") investigating the distribution of acute SARS-CoV-2 infections among children and staff in 99 daycare facilities and 48 elementary schools in Bavaria, Germany., Materials and Methods: Overall, 2,568 children (1,337 school children, 1,231 preschool children) and 1,288 adults (466 teachers, 822 daycare staff) consented to participate in the study and were randomly tested in three consecutive phases (September/October 2020, November/December 2020, March 2021). In total, 7,062 throat swabs were analyzed for SARS-CoV-2 by commercial RT-PCR kits., Results: In phase I, only one daycare worker tested positive. In phase II, SARS-CoV-2 was detected in three daycare workers, two preschool children, and seven school children. In phase III, no sample tested positive. This corresponds to a positive test rate of 0.05% in phase I, 0.4% in phase II and 0% in phase III. Correlation of a positive PCR test result with the local-7-day incidence values showed a strong association of a 7-day-incidence of more than 100/100,000 as compared to <100/100,000 (OR = 10.3 [1.5-438], p < 0.005). After phase III, antibody testing was offered to 713 study participants in elementary schools. A seroprevalence rate of 7.7% (students) and 4.5% (teachers) was determined., Discussion: During the initial waves of the SARS-CoV-2 pandemic, the risk of a positive SARS-CoV-2 result correlated positively with the local 7-day incidence. Hence, the occurrence of SARS-CoV-2 infections were reflected in schools and daycare facilities. An increased risk of SARS-CoV-2 transmission in the setting of daycare and elementary schooling was unlikely., Competing Interests: All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Kern, Kuhlmann, Matl, Ege, Maison, Eckert, von Both, Behrends, Anger, Frühwald, Gerstlauer, Woelfle, Neubert, Melter, Liese, Goettler, Sing, Liebl, Hübner, Klein and the COVID Kids Bavaria Consortium.)

Published
2022
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