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255 results on '"Maio, Vincenza"'

3. Dermoscopy as a Tool for Identifying Potentially Metastatic Thin Melanoma: A Clinical–Dermoscopic and Histopathological Case–Control Study

Author

De Giorgi, Vincenzo, primary, Silvestri, Flavia, additional, Cecchi, Giovanni, additional, Venturi, Federico, additional, Zuccaro, Biancamaria, additional, Perillo, Gabriella, additional, Cosso, Federica, additional, Maio, Vincenza, additional, Simi, Sara, additional, Antonini, Pietro, additional, Pillozzi, Serena, additional, Antonuzzo, Lorenzo, additional, Massi, Daniela, additional, and Doni, Laura, additional

Published
2024
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6. Hydroxychloroquine-induced generalized myopathy in a patient with lupus tumidus: a case report.

Author

Verdelli, Alice, Massi, Daniela, Maio, Vincenza, Cavazza, Gabriele, Corrà, Alberto, Mariotti, Elena Biancamaria, Quintarelli, Lavinia, di Calabria, Valentina Ruffo, Aimo, Cristina, Antiga, Emiliano, and Caproni, Marzia

Subjects
LUPUS erythematosus, MUSCLE diseases, SKIN discoloration, MUCOUS membranes, HEMOLYTIC anemia, URTICARIA
Abstract

A subtype of cutaneous lupus erythematosus known as lupus erythematosus tumidus (LET) is characterized by sun-exposed areas that typically display urticaria-like papules and plaques. For LET, systemic therapy with antimalarials – particularly hydroxychloroquine (HCQ) – is the first line of treatment. Even though the safety profile of these medications appears to be high, there have been very few reports of side effects in the literature, including hemolytic anemia, retinal toxicity, maculopapular rash, gastrointestinal disturbance, and blue-gray discoloration of the skin or mucous membranes. Here, we report a unique instance of a 46- year-old LET smoker who, following HCQ treatment, developed a generalized myopathy. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Genetic characterization of juvenile sudden cardiac arrest and death in Tuscany: The ToRSADE registry

Author

Girolami, Francesca, primary, Spinelli, Valentina, additional, Maurizi, Niccolò, additional, Focardi, Martina, additional, Nesi, Gabriella, additional, Maio, Vincenza, additional, Grifoni, Rossella, additional, Albora, Giuseppe, additional, Bertaccini, Bruno, additional, Targetti, Mattia, additional, Coppini, Raffaele, additional, Favilli, Silvia, additional, Olivotto, Iacopo, additional, and Cerbai, Elisabetta, additional

Published
2022
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14. Case Report: Resolution of Lichen Planus Pemphigoides as an unexpected outcome of SARS-CoV-2 infection.

Author

di Calabria, Valentina Ruffo, Verdelli, Alice, Quintarelli, Lavinia, Corrà, Alberto, Mariotti, Elena Biancamaria, Aimo, Cristina, Del Bianco, Elena, Bianchi, Beatrice, Maio, Vincenza, Massi, Daniela, and Caproni, Marzia

Subjects
LICHEN planus, SARS-CoV-2, VIRUS diseases, COVID-19 pandemic, INFECTION, AUTOIMMUNE diseases, ORAL lichen planus
Abstract

It is well known that viral infections play a relevant role in inducing or protecting from autoimmune diseases, thus representing a major environmental factor in the disruption of the immune system in genetically susceptible individuals. Since the beginning of the Covid-19 pandemic a great number of clinical and epidemiological studies have demonstrated that SARS-CoV-2 infection is no exception to the rule by interfering on many different levels in the normal functioning of our immune system. Even though a growing number of case series and case reports has been cited in the literature linking the infection to the new onset of autoimmune diseases, to date very little has been reported concerning a possible correlation between the virus and the clinical resolution of any kind of autoimmune pathology. Here we describe an interesting case of abrupt and unexpected resolution of Lichen planus pemphigoides mucocutaneous lesions in a fully vaccinated patient after a mildly symptomatic SARS-CoV-2 respiratory infection and we speculate on the possible underlying mechanisms correlating the two events. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Atypical Spitz tumours: an epidemiological, clinical and dermoscopic multicentre study with 16 years of follow‐up

Author

De Giorgi, Vincenzo, primary, Venturi, Federico, additional, Silvestri, Flavia, additional, Trane, Luciana, additional, Savarese, Imma, additional, Scarfì, Federica, additional, Cencetti, Francesca, additional, Pecenco, Silvia, additional, Tramontana, Marta, additional, Maio, Vincenza, additional, Zuccaro, Biancamaria, additional, Colombo, Jacopo, additional, Bagnoni, Giovanni, additional, Stingeni, Luca, additional, and Massi, Daniela, additional

Published
2022
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17. Leprosy misdiagnosed as chronic urticaria in a migrant.

Author

Magnaterra, Elisabetta, Scandagli, Ilaria, Zuccaro, Biancamaria, Maio, Vincenza, Simi, Sara, Massi, Daniela, Fiallo, Paolo, Francalanci, Stefano, Difonzo, Elisa, and Pisano, Luigi

Subjects
URTICARIA, HANSEN'S disease, INFORMED consent (Medical law), NEGLECTED diseases, MYCOBACTERIUM leprae
Abstract

This article presents a case study of a 37-year-old Sri Lankan man who was initially misdiagnosed with chronic urticaria but was later diagnosed with Lepromatous Leprosy. The patient had persistent facial swelling and other symptoms such as nasal bleeding and skin lesions. The diagnosis was confirmed through tests that showed the presence of acid-fast bacilli. The patient was then transferred to a specialized hospital for leprosy treatment. The article highlights the importance of considering leprosy as a differential diagnosis, especially in non-endemic regions. [Extracted from the article]

Published
2024
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21. Disseminated Talaromyces infection in an AIDS patient

Author

Basile, Gregorio, primary, Piccica, Matteo, additional, Vellere, Iacopo, additional, Meli, Massimo, additional, Mazzetti, Marcello, additional, Massi, Daniela, additional, Maio, Vincenza, additional, Cecconi, Daniela, additional, Rossolini, Gian Maria, additional, Bartoloni, Alessandro, additional, and Zammarchi, Lorenzo, additional

Published
2022
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22. Tumor Infiltrating Lymphocytes Recognition in Primary Melanoma by Deep Learning Convolutional Neuronal Network

Author

Ugolini, Filippo, primary, De Logu, Francesco, additional, Iannone, Luigi Francesco, additional, Brutti, Francesca, additional, Simi, Sara, additional, Maio, Vincenza, additional, de Giorgi, Vincenzo, additional, Maria di Giacomo, Anna, additional, Miracco, Clelia, additional, Federico, Francesco, additional, Peris, Ketty, additional, Palmieri, Giuseppe, additional, Cossu, Antonio, additional, Mandalà, Mario, additional, Massi, Daniela, additional, and Laurino, Marco, additional

Published
2022
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26. Treatment of periocular advanced basal cell carcinoma with Hedgehog pathway inhibitors: a single-center study and a new dedicated therapeutic protocol

Author

De Giorgi, Vincenzo, primary, Trane, Luciana, additional, Pieretti, Giulia, additional, Santoro, Nicola, additional, Silvestri, Flavia, additional, Venturi, Federico, additional, Scarfi, Federica, additional, Maio, Vincenza, additional, Spinelli, Giuseppe, additional, Scoccianti, Silvia, additional, Guerrini, Laura, additional, Massi, Daniela, additional, Mazzini, Cinzia, additional, and Doni, Laura, additional

Published
2021
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33. Fluorescence‐advanced videodermatoscopy (FAV) for the differential diagnosis of suspicious facial lesions: A single‐centre experience with pattern analysis and histopathological correlation.

Author

Scarfì, Federica, Trane, Luciana, Maio, Vincenza, Silvestri, Flavia, Venturi, Federico, Zuccaro, Biancamaria, Massi, Daniela, and De Giorgi, Vincenzo

Subjects
DIFFERENTIAL diagnosis, ACTINIC keratosis, SKIN imaging, LENTIGO, STATISTICAL correlation
Abstract

Background: Fluorescence‐advanced videodermatoscopy (FAV) is a new non‐invasive high‐resolution skin imaging technique to assess pigmented lesions in conjunction with the clinical examination and dermatoscopy. Objectives: This is the first prospective study to identify morphologic descriptors and standardized terminology to examine facial pigmented lesions using FAV. The objectives were to identify FAV indicators, which can assist physicians in diagnosing suspicious flat facial pigmented lesions. Methods: Consecutive equivocal pigmented lesions were retrospective analysed. Histopathological examination was performed for all the lesions. The main cytomorphological and cytoarchitectural FAV features were described and correlated with histopathological characteristics. Results: From January to October 2020, 21 consecutive clinically suspected pigmented lesions in 20 patients were analysed using dermatoscopy and FAV and then surgically excised. Histopathological examination identified lentigo maligna (LM), lentigo maligna melanoma (LMM), solar lentigo (SL), flat seborrheic keratosis (SK) and pigmented actinic keratosis (PAK). Thirteen malignant melanocytic lesions were removed (11 LM, 2 LMM), two were diagnosed as PAK, and the remaining six pigmented lesions were SL‐SKs. With FAV, large ovoid pleomorphic and dendritic cells arranged in the intrafollicular disposition, are typical of most malignant melanocytic lesions (12/13, 92.3%). No benign lesions displayed these features. In dermatoscopy, this folliculotropism corresponded to the presence of an annular‐granular pattern with slate grey dots that were aggregated asymmetrically around follicular openings. Conclusions: FAV features can provide an improved diagnostic approach in the differential diagnosis of flat pigmented facial lesions. [ABSTRACT FROM AUTHOR]

Published
2022
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44. Recognition of Cutaneous Melanoma on Digitized Histopathological Slides via Artificial Intelligence Algorithm.

Author

De Logu, Francesco, Ugolini, Filippo, Maio, Vincenza, Simi, Sara, Cossu, Antonio, Massi, Daniela, Nassini, Romina, and Laurino, Marco

Subjects
CONVOLUTIONAL neural networks, ARTIFICIAL intelligence, ALGORITHMS, BIG data, MACHINE learning
Abstract

Increasing incidence of skin cancer combined with a shortage of dermatopathologists has increased the workload of pathology departments worldwide. In addition, the high intraobserver and interobserver variability in the assessment of melanocytic skin lesions can result in underestimated or overestimated diagnosis of melanoma. Thus, the development of new techniques for skin tumor diagnosis is essential to assist pathologists to standardize diagnoses and plan accurate patient treatment. Here, we describe the development of an artificial intelligence (AI) system that recognizes cutaneous melanoma from histopathological digitalized slides with clinically acceptable accuracy. Whole-slide digital images from 100 formalin-fixed paraffin-embedded primary cutaneous melanoma were used to train a convolutional neural network (CNN) based on a pretrained Inception-ResNet-v2 to accurately and automatically differentiate tumoral areas from healthy tissue. The CNN was trained by using 60 digital slides in which regions of interest (ROIs) of tumoral and healthy tissue were extracted by experienced dermatopathologists, while the other 40 slides were used as test datasets. A total of 1377 patches of healthy tissue and 2141 patches of melanoma were assessed in the training/validation set, while 791 patches of healthy tissue and 1122 patches of pathological tissue were evaluated in the test dataset. Considering the classification by expert dermatopathologists as reference, the trained deep net showed high accuracy (96.5%), sensitivity (95.7%), specificity (97.7%), F1 score (96.5%), and a Cohen's kappa of 0.929. Our data show that a deep learning system can be trained to recognize melanoma samples, achieving accuracies comparable to experienced dermatopathologists. Such an approach can offer a valuable aid in improving diagnostic efficiency when expert consultation is not available, as well as reducing interobserver variability. Further studies in larger data sets are necessary to verify whether the deep learning algorithm allows subclassification of different melanoma subtypes. [ABSTRACT FROM AUTHOR]

Published
2020
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