Search

Your search keyword '"Mainland, Joel D."' showing total 174 results
Start Over Author "Mainland, Joel D."
174 results on '"Mainland, Joel D."'

4. A competitive binding model predicts nonlinear responses of olfactory receptors to complex mixtures

Author

Singh, Vijay, Murphy, Nicolle R., Balasubramanian, Vijay, and Mainland, Joel D.

Subjects
Quantitative Biology - Neurons and Cognition, Physics - Biological Physics
Abstract

In color vision, the quantitative rules for mixing lights to make a target color are well understood. By contrast, the rules for mixing odorants to make a target odor remain elusive. A solution to this problem in vision relied on characterizing receptor responses to different wavelengths of light and subsequently relating these responses to perception. In olfaction, experimentally measuring receptor responses to a representative set of complex mixtures is intractable due to the vast number of possibilities. To meet this challenge, we develop a biophysical model that predicts mammalian receptor responses to complex mixtures using responses to single odorants. The dominant nonlinearity in our model is competitive binding (CB): only one odorant molecule can attach to a receptor binding site at a time. This simple framework predicts receptor responses to mixtures of up to twelve monomolecular odorants to within 15\% of experimental observations and provides a powerful method for leveraging limited experimental data. Simple extensions of our model describe phenomena such as synergy, overshadowing, and inhibition. We demonstrate that the presence of such interactions can be identified via systematic deviations from the competitive binding model.

Published
2018
Full Text
View/download PDF

7. Anosmia-A Clinical Review.

Author

Boesveldt, Sanne, Postma, Elbrich M, Boak, Duncan, Welge-Luessen, Antje, Schöpf, Veronika, Mainland, Joel D, Martens, Jeffrey, Ngai, John, and Duffy, Valerie B

Subjects
Clinical Research, Neurosciences, Rare Diseases, Good Health and Well Being, Delivery of Health Care, Humans, Neuronal Plasticity, Olfaction Disorders, Prognosis, Quality of Life, Smell, Stem Cell Transplantation, genetics, neural reorganization, olfactory dysfunction, quality of life, stem cell regeneration, treatment, Biological Sciences, Neurology & Neurosurgery
Abstract

Anosmia and hyposmia, the inability or decreased ability to smell, is estimated to afflict 3-20% of the population. Risk of olfactory dysfunction increases with old age and may also result from chronic sinonasal diseases, severe head trauma, and upper respiratory infections, or neurodegenerative diseases. These disorders impair the ability to sense warning odors in foods and the environment, as well as hinder the quality of life related to social interactions, eating, and feelings of well-being. This article reports and extends on a clinical update commencing at the 2016 Association for Chemoreception Sciences annual meeting. Included were reports from: a patient perspective on losing the sense of smell with information on Fifth Sense, a nonprofit advocacy organization for patients with olfactory disorders; an otolaryngologist's review of clinical evaluation, diagnosis, and management/treatment of anosmia; and researchers' review of recent advances in potential anosmia treatments from fundamental science, in animal, cellular, or genetic models. As limited evidence-based treatments exist for anosmia, dissemination of information on anosmia-related health risks is needed. This could include feasible and useful screening measures for olfactory dysfunction, appropriate clinical evaluation, and patient counseling to avoid harm as well as manage health and quality of life with anosmia.

Published
2017

8. Predicting human olfactory perception from chemical features of odor molecules

Author

Keller, Andreas, Gerkin, Richard C, Guan, Yuanfang, Dhurandhar, Amit, Turu, Gabor, Szalai, Bence, Mainland, Joel D, Ihara, Yusuke, Yu, Chung Wen, Wolfinger, Russ, Vens, Celine, schietgat, leander, De Grave, Kurt, Norel, Raquel, Consortium, DREAM Olfaction Prediction, Stolovitzky, Gustavo, Cecchi, Guillermo A, Vosshall, Leslie B, and meyer, pablo

Subjects
Neurosciences, Adult, Datasets as Topic, Humans, Male, Models, Biological, Odorants, Olfactory Perception, Smell, DREAM Olfaction Prediction Consortium, General Science & Technology
Abstract

It is still not possible to predict whether a given molecule will have a perceived odor or what olfactory percept it will produce. We therefore organized the crowd-sourced DREAM Olfaction Prediction Challenge. Using a large olfactory psychophysical data set, teams developed machine-learning algorithms to predict sensory attributes of molecules based on their chemoinformatic features. The resulting models accurately predicted odor intensity and pleasantness and also successfully predicted 8 among 19 rated semantic descriptors ("garlic," "fish," "sweet," "fruit," "burnt," "spices," "flower," and "sour"). Regularized linear models performed nearly as well as random forest-based ones, with a predictive accuracy that closely approaches a key theoretical limit. These models help to predict the perceptual qualities of virtually any molecule with high accuracy and also reverse-engineer the smell of a molecule.

Published
2017

12. Predicting human olfactory perception from chemical features of odor molecules

Author

DREAM Olfaction Prediction Consortium, Keller, Andreas, Gerkin, Richard C., Guan, Yuanfang, Dhurandhar, Amit, Turu, Gabor, Szalai, Bence, Mainland, Joel D., Ihara, Yusuke, Yu, Chung Wen, Wolfinger, Russ, Vens, Celine, Schietgat, Leander, De Grave, Kurt, Norel, Raquel, Stolovitzky, Gustavo, Cecchi, Guillermo A., Vosshall, Leslie B., and Meyer, Pablo

Published
2017

14. Identifying candidate genes underlying isolated congenital anosmia.

Author

Kamarck, Marissa L., Trimmer, Casey, Murphy, Nicolle R., Gregory, Kristen M., Manoel, Diogo, Logan, Darren W., Saraiva, Luis R., and Mainland, Joel D.

Subjects
OLFACTORY receptors, ZINC ions, GENE families, SMELL, GENES, GENETIC variation, AGENESIS of corpus callosum
Abstract

An estimated 1 in 10 000 people are born without the ability to smell, a condition known as congenital anosmia, and about one third of those people have non‐syndromic, or isolated congenital anosmia (ICA). Despite the significant impact of olfaction for our quality of life, the underlying causes of ICA remain largely unknown. Using whole exome sequencing (WES) in 10 families and 141 individuals with ICA, we identified a candidate list of 162 rare, segregating, deleterious variants in 158 genes. We confirmed the involvement of CNGA2, a previously implicated ICA gene that is an essential component of the olfactory transduction pathway. Furthermore, we found a loss‐of‐function variant in SREK1IP1 from the family gene candidate list, which was also observed in 5% of individuals in an additional non‐family cohort with ICA. Although SREK1IP1 has not been previously associated with olfaction, its role in zinc ion binding suggests a potential influence on olfactory signaling. This study provides a more comprehensive understanding of the spectrum of genetic alterations and their etiology in ICA patients, which may improve the diagnosis, prognosis, and treatment of this disorder and lead to better understanding of the mechanisms governing basic olfactory function. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

20. Pyrfume: A Window to the World’s Olfactory Data

Author

Castro, Jason B., primary, Gould, Travis J., additional, Pellegrino, Robert, additional, Liang, Zhiwei, additional, Coleman, Liyah A., additional, Patel, Famesh, additional, Wallace, Derek S., additional, Bhatnagar, Tanushri, additional, Mainland, Joel D., additional, and Gerkin, Richard C., additional

Published
2022
Full Text
View/download PDF

21. A Principal Odor Map Unifies Diverse Tasks in Human Olfactory Perception

Author

Lee, Brian K., primary, Mayhew, Emily J., additional, Sanchez-Lengeling, Benjamin, additional, Wei, Jennifer N., additional, Qian, Wesley W., additional, Little, Kelsie, additional, Andres, Matthew, additional, Nguyen, Britney B., additional, Moloy, Theresa, additional, Parker, Jane K., additional, Gerkin, Richard C., additional, Mainland, Joel D., additional, and Wiltschko, Alexander B., additional

Published
2022
Full Text
View/download PDF

24. From musk to body odor: Decoding olfaction through genetic variation

Author

Leerstoel Smeets, Social-cognitive and interpersonal determinants of behaviour, Li, Bingjie, Kamarck, Marissa L, Peng, Qianqian, Lim, Fei-Ling, Keller, Andreas, Smeets, Monique A M, Mainland, Joel D, Wang, Sijia, Leerstoel Smeets, Social-cognitive and interpersonal determinants of behaviour, Li, Bingjie, Kamarck, Marissa L, Peng, Qianqian, Lim, Fei-Ling, Keller, Andreas, Smeets, Monique A M, Mainland, Joel D, and Wang, Sijia

Published
2022

26. Prevalence and correlates of parosmia and phantosmia among smell disorders

Author

Pellegrino, Robert, Mainland, Joel D., Kelly, Christine E., Parker, Jane K., and Hummel, Thomas

Abstract

Among those many individuals who suffer from a reduced odor sensitivity (hyposmia/anosmia) some individuals also experience disorders that lead to odor distortion, such as parosmia (i.e., distorted odor with a known source), or odor phantoms (i.e., odor sensation without an odor source). We surveyed a large population with at least one olfactory disorder (N = 2031) and found that odor distortions were common (46%), with respondents reporting either parosmia (19%), phantosmia (11%), or both (16%). In comparison to respondents with hyposmia or anosmia, respondents with parosmia were more likely to be female, young, and suffering from post-viral olfactory loss (p < 0.001), while respondents with phantosmia were more likely to be middle-aged (p < 0.01) and experiencing symptoms caused by head trauma (p < 0.01). In addition, parosmia, compared to phantosmia or anosmia/hyposmia, was most prevalent 3 months to a year after olfactory symptom onset (p < 0.001), which coincides with the timeline of physiological recovery. Finally, we observed that the frequency and duration of distortions negatively affects quality of life, with parosmia showing a higher range of severity than phantosmia (p < 0.001). Previous research often grouped these distortions together, but our results show that they have distinct patterns of demographics, medical history, and loss in quality of life.

Published
2021

28. A 3D transcriptomics atlas of the mouse olfactory mucosa

Author

Segura, Mayra L. Ruiz Tejada, primary, Moussa, Eman Abou, additional, Garabello, Elisa, additional, Nakahara, Thiago S., additional, Makhlouf, Melanie, additional, Mathew, Lisa S., additional, Valle, Filippo, additional, Huang, Susie S.Y., additional, Mainland, Joel D., additional, Caselle, Michele, additional, Osella, Matteo, additional, Lorenz, Stephan, additional, Reisert, Johannes, additional, Logan, Darren W., additional, Malnic, Bettina, additional, Scialdone, Antonio, additional, and Saraiva, Luis R., additional

Published
2021
Full Text
View/download PDF

30. The perception of odor pleasantness is shared across cultures

Author

Arshamian, Artin, primary, Gerkin, Richard C., additional, Kruspe, Nicole, additional, Wnuk, Ewelina, additional, Floyd, Simeon, additional, O’Meara, Carolyn, additional, Rodriguez, Gabriela Garrido, additional, Lundström, Johan N., additional, Mainland, Joel D., additional, and Majid, Asifa, additional

Published
2021
Full Text
View/download PDF

33. Drawing the Borders of Olfactory Space

Author

Mayhew, Emily J., primary, Arayata, Charles J., additional, Gerkin, Richard C., additional, Lee, Brian K., additional, Magill, Jonathan M., additional, Snyder, Lindsey L., additional, Little, Kelsie A., additional, Yu, Chung Wen, additional, and Mainland, Joel D., additional

Published
2020
Full Text
View/download PDF

35. Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities

Author

Mainland, Joel D, primary, Barlow, Linda A, additional, Munger, Steven D, additional, Millar, Sarah E, additional, Vergara, M Natalia, additional, Jiang, Peihua, additional, Schwob, James E, additional, Goldstein, Bradley J, additional, Boye, Shannon E, additional, Martens, Jeffrey R, additional, Leopold, Donald A, additional, Bartoshuk, Linda M, additional, Doty, Richard L, additional, Hummel, Thomas, additional, Pinto, Jayant M, additional, Trimmer, Casey, additional, Kelly, Christine, additional, Pribitkin, Edmund A, additional, and Reed, Danielle R, additional

Published
2020
Full Text
View/download PDF

37. Sensory nutrition: The role of taste in the reviews of commercial food products

Author

Reed, Danielle. R., Mainland, Joel D., and Arayata, Charles J.

Subjects
Taste, Sensation, Experimental and Cognitive Psychology, Sensory system, Food Preferences, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Product reviews, Animals, Food Industry, Humans, Customer service, Nutritional Physiological Phenomena, 0501 psychology and cognitive sciences, 050102 behavioral science & comparative psychology, 05 social sciences, Advertising, Consumer Behavior, Sweetness, Purchasing, Product (business), Food, Food products, Food quality, Psychology, 030217 neurology & neurosurgery
Abstract

Many factors play a role in choosing what to eat or drink. Here we explored the role of sensation to explain these differences, drawing on consumer reviews for commercially available food products sold through an online retailer. We analyzed 393,568 unique food product reviews from Amazon customers with a total of 256,043 reviewers rating 67,553 products. Taste-associated words were mentioned more than words associated with cost, food texture, customer service, nutrition, smell, or those referring to the trigeminal senses, e.g., spicy. We computed the overall number of reviews that mentioned taste qualities: the wordtastewas mentioned in over 30% of the reviews (N= 142,768), followed bysweet(10.7%, N=42,315),bitter(2.9%, N=11,424),sour(2.1%, N=8,252), andsalty(1.4%, N=5,688). We identified 38 phrases used to describe the evaluation of sweetness, finding that ‘too sweet’ was used in nearly 0.8% of the reviews and oversweetness was mentioned over 25 times more often than under-sweetness. We then focused on ‘polarizing’ products, those that elicited a wide difference of opinion (as measured by the ranges of the product ratings). Using the products that had more than 50 reviews, we identified the top 10 most polarizing foods (i.e., those with the largest standard deviation in ratings) and provide representative comments about the polarized taste experience of consumers. Overall, these results support the primacy of taste in real-world food ratings and individualized taste experience, such as whether a product is ‘too sweet’. Analysis of consumer review data sets can provide information about purchasing decisions and customer sensory responses to particular commercially available products and represents a promising methodology for the emerging field of sensory nutrition.

Published
2019
Full Text
View/download PDF

40. A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans

Author

Saraiva, Luis R., primary, Riveros-McKay, Fernando, additional, Mezzavilla, Massimo, additional, Abou-Moussa, Eman H., additional, Arayata, Charles J., additional, Makhlouf, Melanie, additional, Trimmer, Casey, additional, Ibarra-Soria, Ximena, additional, Khan, Mona, additional, Van Gerven, Laura, additional, Jorissen, Mark, additional, Gibbs, Matthew, additional, O’Flynn, Ciaran, additional, McGrane, Scott, additional, Mombaerts, Peter, additional, Marioni, John C., additional, Mainland, Joel D., additional, and Logan, Darren W., additional

Published
2019
Full Text
View/download PDF

45. Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated

Author

Ibarra-Soria, Ximena, primary, Nakahara, Thiago S., additional, Lilue, Jingtao, additional, Jiang, Yue, additional, Trimmer, Casey, additional, Souza, Mateus A. A., additional, Netto, Paulo H. M., additional, Ikegami, Kentaro, additional, Murphy, Nicolle R., additional, Kusma, Mairi, additional, Kirton, Andrea, additional, Saraiva, Luis R., additional, Keane, Thomas M., additional, Matsunami, Hiroaki, additional, Mainland, Joel D., additional, Papes, Fabio, additional, and Logan, Darren W., additional

Published
2016
Full Text
View/download PDF

48. The missense of smell: functional variability in the human odorant receptor repertoire

Author

Mainland, Joel D, primary, Keller, Andreas, additional, Li, Yun R, additional, Zhou, Ting, additional, Trimmer, Casey, additional, Snyder, Lindsey L, additional, Moberly, Andrew H, additional, Adipietro, Kaylin A, additional, Liu, Wen Ling L, additional, Zhuang, Hanyi, additional, Zhan, Senmiao, additional, Lee, Somin S, additional, Lin, Abigail, additional, and Matsunami, Hiroaki, additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results