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19 results on '"Mainberger, Florian"'

8. Differential effects of bifrontal tDCS on arousal and sleep duration in insomnia patients and healthy controls

Author

Frase, Lukas, primary, Selhausen, Peter, additional, Krone, Lukas, additional, Tsodor, Sulamith, additional, Jahn, Friederike, additional, Feige, Bernd, additional, Maier, Jonathan G., additional, Mainberger, Florian, additional, Piosczyk, Hannah, additional, Kuhn, Marion, additional, Klöppel, Stefan, additional, Sterr, Annette, additional, Baglioni, Chiara, additional, Spiegelhalder, Kai, additional, Riemann, Dieter, additional, Nitsche, Michael A., additional, and Nissen, Christoph, additional

Published
2019
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9. Sleep orchestrates indices of local plasticity and global network stability in the human cortex

Author

Maier, Jonathan G, primary, Kuhn, Marion, additional, Mainberger, Florian, additional, Nachtsheim, Katharina, additional, Guo, Stephanie, additional, Bucsenez, Ulrike, additional, Feige, Bernd, additional, Mikutta, Christian, additional, Spiegelhalder, Kai, additional, Klöppel, Stefan, additional, Normann, Claus, additional, Riemann, Dieter, additional, and Nissen, Christoph, additional

Published
2018
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10. LTP-like plasticity in the visual system and in the motor system appear related in young and healthy subjects

Author

Klöppel, Stefan, Lauer, Eliza, Peter, Jessica, Minkova, Lora, Nissen, Christoph, Normann, Claus, Reis, Janine, Mainberger, Florian, Bach, Michael, and Lahr, Jacob

Subjects
long-term potentiation (LTP), genetic structures, musculoskeletal, neural, and ocular physiology, LTP-like plasticity, neuroplasticity, verbal learning, VEP potentiation, paired associative stimulation (PAS), motor learning, Original Research, Neuroscience
Abstract

LTP-like plasticity measured by visual evoked potentials (VEP) can be induced in the intact human brain by presenting checkerboard reversals. Also associated with LTP-like plasticity, around two third of participants respond to transcranial magnetic stimulation (TMS) with a paired-associate stimulation (PAS) protocol with a potentiation of their motor evoked potentials. LTP-like processes are also required for verbal and motor learning tasks. We compared effect sizes, responder rates and intercorrelations as well as the potential influence of attention between these four assessments in a group of 37 young and healthy volunteers. We observed a potentiation effect of the N75 and P100 VEP component which positively correlated with plasticity induced by PAS. Subjects with a better subjective alertness were more likely to show PAS and VEP potentiation. No correlation was found between the other assessments. Effect sizes and responder rates of VEP potentiation were higher compared to PAS. Our results indicate a high variability of LTP-like effects and no evidence for a system-specific nature. As a consequence, studies wishing to assess individual levels of LTP-like plasticity should employ a combination of multiple assessments.

Published
2015
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12. Sleep recalibrates homeostatic and associative synaptic plasticity in the human cortex

Author

Kuhn, Marion, primary, Wolf, Elias, additional, Maier, Jonathan G., additional, Mainberger, Florian, additional, Feige, Bernd, additional, Schmid, Hanna, additional, Bürklin, Jan, additional, Maywald, Sarah, additional, Mall, Volker, additional, Jung, Nikolai H., additional, Reis, Janine, additional, Spiegelhalder, Kai, additional, Klöppel, Stefan, additional, Sterr, Annette, additional, Eckert, Anne, additional, Riemann, Dieter, additional, Normann, Claus, additional, and Nissen, Christoph, additional

Published
2016
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13. Modulation of Total Sleep Time by Transcranial Direct Current Stimulation (tDCS)

Author

Frase, Lukas, primary, Piosczyk, Hannah, additional, Zittel, Sulamith, additional, Jahn, Friederike, additional, Selhausen, Peter, additional, Krone, Lukas, additional, Feige, Bernd, additional, Mainberger, Florian, additional, Maier, Jonathan G, additional, Kuhn, Marion, additional, Klöppel, Stefan, additional, Normann, Claus, additional, Sterr, Annette, additional, Spiegelhalder, Kai, additional, Riemann, Dieter, additional, Nitsche, Michael A, additional, and Nissen, Christoph, additional

Published
2016
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16. Lovastatin improves impaired synaptic plasticity and phasic alertness in patients with neurofibromatosis type 1

Author

Mainberger, Florian, primary, Jung, Nikolai H, additional, Zenker, Martin, additional, Wahlländer, Ute, additional, Freudenberg, Leonie, additional, Langer, Susanne, additional, Berweck, Steffen, additional, Winkler, Tobias, additional, Straube, Andreas, additional, Heinen, Florian, additional, Granström, Sofia, additional, Mautner, Victor-Felix, additional, Lidzba, Karen, additional, and Mall, Volker, additional

Published
2013
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18. State-Dependent Partial Occlusion of Cortical LTP-Like Plasticity in Major Depression

Author

Kuhn, Marion, Mainberger, Florian, Feige, Bernd, Maier, Jonathan G, Mall, Volker, Jung, Nicolai H, Reis, Janine, Klöppel, Stefan, Normann, Claus, and Nissen, Christoph

Abstract

The synaptic plasticity hypothesis of major depressive disorder (MDD) posits that alterations in synaptic plasticity represent a final common pathway underlying the clinical symptoms of the disorder. This study tested the hypotheses that patients with MDD show an attenuation of cortical synaptic long-term potentiation (LTP)-like plasticity in comparison with healthy controls, and that this attenuation recovers after remission. Cortical synaptic LTP-like plasticity was measured using a transcranial magnetic stimulation protocol, ie, paired associative stimulation (PAS), in 27 in-patients with MDD according to ICD-10 criteria and 27 sex- and age-matched healthy controls. The amplitude of motor-evoked potentials was measured before and after PAS. Patients were assessed during the acute episode and at follow-up to determine the state- or trait-character of LTP-like changes. LTP-like plasticity, the PAS-induced increase in motor-evoked potential amplitudes, was significantly attenuated in patients with an acute episode of MDD compared with healthy controls. Patients with remission showed a restoration of synaptic plasticity, whereas the deficits persisted in patients without remission, indicative for a state-character of impaired LTP-like plasticity. The results provide first evidence for a state-dependent partial occlusion of cortical LTP-like plasticity in MDD. This further identifies impaired LTP-like plasticity as a potential pathomechanism and treatment target of the disorder.

Published
2016
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