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Small fractions of patients suffer from radiotherapy late severe adverse events (AEs Grade ≥ 3), which are usually irreversible and badly affect their quality of life. A novel functional DNA repair assay characterizing several steps of double-strand break (DSB) repair mechanisms was used. DNA repair activities of peripheral blood mononuclear cells were monitored for 1 week using NEXT-SPOT assay in 177 breast and prostate cancer patients. Only seven patients had Grade ≥ 3 AEs, 6 months after radiotherapy initiation. The machine learning method established the importance of variables among demographic, clinical and DNA repair data. The most relevant ones, all related to DNA repair, were employed to build a predictor. Predictors constructed with random forest and minimum bounding sphere predicted late Grade ≥ 3 AEs with a sensitivity of 100% and specificity of 77.17 and 86.22%, respectively. This multiplex functional approach strongly supports a dominant role for DSB repair in the development of chronic AEs. It also showed that affected patients share specific features related to functional aspects of DSB repair. This strategy may be suitable for routine clinical analysis and paves the way for modelling DSB repair associated with severe AEs induced by radiotherapy. [ABSTRACT FROM AUTHOR]

Interstoff (launched in 1959 by Messe Frankfurt) and Première Vision (launched in 1972 in Lyon) became “information dissemination gathering locations” for the fashion and textile industries all over the world. The two events mobilized the fashion prediction methodology as a key tool to impose themselves as the favorite information gatekeeper for the industry. Their goal was to complement the trading of goods with the exchange of adequate and strategic information for companies that were dramatically constrained by immediate global competition and rapidly changing seasonal models. As a result the two trade fairs progressively adopted a new information-centric model and contributed to maintain Western Europe as the central location for the dissemination of fashion trends worldwide. Messe Frankfurt also pursued an alternative geographical strategy. It did this by following the global relocation of textile manufacturing and setting up fairs around the world, particularly in China, before ultimately ending the Interstoff event in Frankfurt in 1999. [ABSTRACT FROM AUTHOR]