Search

Your search keyword '"Maillard, Michel H."' showing total 172 results
Start Over Author "Maillard, Michel H."
172 results on '"Maillard, Michel H."'

1. Alcohol and cannabis consumption in patients with inflammatory bowel disease: prevalence, pattern of consumption and impact on the disease

Author

Martinho-Grueber, Maude, Kapoglou, Ioannis, Bravo, Francisco, Sarraj, Riad, Benz, Eileen, Restellini, Sophie, Biedermann, Luc, Rogler, Gerhard, Vavricka, Stephan R., Schoepfer, Alain, Maillard, Michel H., Michetti, Pierre, Brunner, Felix, Clair, Carole, Barry, Mamadou Pathe, Pittet, Valérie, von Känel, Roland, and Juillerat, Pascal

Published
2023
Full Text
View/download PDF

3. Impact of Overweight and Obesity on Disease Outcome in the Pediatric Swiss Inflammatory Bowel Disease Cohort

Author

von Graffenried, Thea, Schoepfer, Alain M., Rossel, Jean-Benoit, Greuter, Thomas, Safroneeva, Ekaterina, Godat, Sébastien, Henchoz, Sarah, Vavricka, Stephan R., Sokollik, Christiane, Spalinger, Johannes, Braegger, Christian P., Nydegger, Andreas, Abdelrahman, Karim, Ademi, Gentiana, Aepli, Patrick, Thomas, Amman, Anderegg, Claudia, Antonino, Anca-Teodora, Archanioti, Eva, Arrigoni, Eviano, de Jong, Diana Bakker, Balsiger, Bruno, Bastürk, Polat, Bauerfeind, Peter, Becocci, Andrea, Belli, Dominique, Bengoa, José M., Biedermann, Luc, Binek, Janek, Blattmann, Mirjam, Boehm, Stephan, Boldanova, Tujana, Borovicka, Jan, Braegger, Christian P., Brand, Stephan, Brügger, Lukas, Brunner, Simon, Bühr, Patrick, Burnand, Bernard, Burk, Sabine, Burri, Emanuel, Buyse, Sophie, Cao, Dahlia-Thao, Carstens, Ove, Criblez, Dominique H., Cunningham, Sophie, D’Angelo, Fabrizia, de Saussure, Philippe, Degen, Lukas, Delarive, Joakim, Doerig, Christopher, Dora, Barbara, Drerup, Susan, Egger, Mara, El-Wafa, Ali, Engelmann, Matthias, Felley, Christian, Fliegner, Markus, Fournier, Nicolas, Fraga, Montserrat, Franc, Yannick, Frei, Pascal, Frei, Remus, Fried, Michael, Froehlich, Florian, Furlano, Raoul Ivano, Garzoni, Luca, Geyer, Martin, Girard, Laurent, Girardin, Marc, Golay, Delphine, Good, Ignaz, Bigler, Ulrike Graf, Gysi, Beat, Haarer, Johannes, Halama, Marcel, Haldemann, Janine, Heer, Pius, Heimgartner, Benjamin, Helbling, Beat, Hengstler, Peter, Herzog, Denise, Hess, Cyrill, Heyland, Klaas, Hinterleitner, Thomas, Hirschi, Claudia, Hruz, Petr, Juillerat, Pascal, Khalid-de Bakker, Carolina, Kayser, Stephan, Keller, Céline, Knellwolf, Christina, Knoblauch, Christoph, Köhler, Henrik, Koller, Rebekka, Krieger, Claudia, Künzler, Patrizia, Kusche, Rachel, Lehmann, Frank Serge, Macpherson, Andrew, Maillard, Michel H., Manz, Michael, Marot, Astrid, Meier, Rémy, Meyenberger, Christa, Meyer, Pamela, Michetti, Pierre, Misselwitz, Benjamin, Mosler, Patrick, Mottet, Christian, Müller, Christoph, Müllhaupt, Beat, Musso, Leilla, Neagu, Michaela, Nichita, Cristina, Niess, Jan, Nydegger, Andreas, Obialo, Nicole, Ollo, Diana, Oropesa, Cassandra, Peter, Ulrich, Peternac, Daniel, Petit, Laetitia Marie, Pittet, Valérie, Pohl, Daniel, Porzner, Marc, Preissler, Claudia, Raschle, Nadia, Rentsch, Ronald, Restellini, Alexandre, Restellini, Sophie, Richterich, Jean-Pierre, Ris, Frederic, Risti, Branislav, Ritz, Marc Alain, Rogler, Gerhard, Röhrich, Nina, Rossel, Jean-Benoît, Rueger, Vanessa, Rusticeanu, Monica, Sagmeister, Markus, Saner, Gaby, Sauter, Bernhard, Sawatzki, Mikael, Scharl, Michael, Schelling, Martin, Schibli, Susanne, Schlauri, Hugo, Schluckebier, Dominique, Schmid, Daniela, Schmid, Sybille, Schnegg, Jean-François, Schoepfer, Alain, Seematter, Vivianne, Seibold, Frank, Seirafi, Mariam, Semadeni, Gian-Marco, Senning, Arne, Sokollik, Christiane, Sommer, Joachim, Spalinger, Johannes, Spangenberger, Holger, Stadler, Philippe, Staub, Peter, Staudenmann, Dominic, Stenz, Volker, Steuerwald, Michael, Straumann, Alex, Stulz, Andreas, Sulz, Michael, Tatu, Aurora, Tempia-Caliera, Michela, Thorens, Joël, Truninger, Kaspar, Tutuian, Radu, Urfer, Patrick, Vavricka, Stephan, Viani, Francesco, Vögtlin, Jürg, Von Känel, Roland, Vouillamoz, Dominique, Vulliamy, Rachel, Wiesel, Paul, Wiest, Reiner, Wöhrle, Stefanie, Zamora, Samuel, Zander, Silvan, Zeitz, Jonas, and Zimmermann, Dorothee

Published
2022
Full Text
View/download PDF

4. Differences in Outcomes Reported by Patients With Inflammatory Bowel Diseases vs Their Health Care Professionals

Author

Anderegg, Claudia, Bauerfeind, Peter, Beglinger, Christoph, Begré, Stefan, Belli, Dominique, Bengoa, José M., Biedermann, Luc, Bigler, Beat, Binek, Janek, Blattmann, Mirjam, Boehm, Stephan, Borovicka, Jan, Braegger, Christian P., Brunner, Nora, Bühr, Patrick, Burnand, Bernard, Burri, Emanuel, Buyse, Sophie, Cremer, Matthias, Criblez, Dominique H., de Saussure, Philippe, Degen, Lukas, Delarive, Joakim, Doerig, Christopher, Dora, Barbara, Dorta, Gian, Egger, Mara, Ehmann, Tobias, El-Wafa, Ali, Engelmann, Matthias, Ezri, Jessica, Felley, Christian, Fliegner, Markus, Fournier, Nicolas, Fraga, Montserrat, Frei, Pascal, Frei, Remus, Fried, Michael, Froehlich, Florian, Funk, Christian, Furlano, Raoul Ivano, Gallot-Lavallée, Suzanne, Geyer, Martin, Girardin, Marc, Golay, Delphine, Grandinetti, Tanja, Gysi, Beat, Haack, Horst, Haarer, Johannes, Helbling, Beat, Hengstler, Peter, Herzog, Denise, Hess, Cyrill, Heyland, Klaas, Hinterleitner, Thomas, Hiroz, Philippe, Hirschi, Claudia, Hruz, Petr, Iwata, Rika, Jost, Res, Juillerat, Pascal, Keller, Céline, Knellwolf, Christina, Knoblauch, Christoph, Köhler, Henrik, Koller, Rebekka, Krieger-Grübel, Claudia, Kullak-Ublick, Gerd, Künzler, Patrizia, Landolt, Markus, Lange, Rupprecht, Lehmann, Frank Serge, Macpherson, Andrew, Maerten, Philippe, Maillard, Michel H., Manser, Christine, Manz, Michael, Marbet, Urs, Marx, George, Matter, Christoph, Meier, Rémy, Mendanova, Martina, Michetti, Pierre, Misselwitz, Benjamin, Morell, Bernhard, Mosler, Patrick, Mottet, Christian, Müller, Christoph, Müller, Pascal, Müllhaupt, Beat, Münger-Beyeler, Claudia, Musso, Leilla, Nagy, Andreas, Neagu, Michaela, Nichita, Cristina, Niess, Jan, Nydegger, Andreas, Obialo, Nicole, Oneta, Carl, Oropesa, Cassandra, Peter, Ueli, Peternac, Daniel, Petit, Laetitia Marie, Piccoli-Gfeller, Franziska, Pilz, Julia Beatrice, Pittet, Valérie, Raschle, Nadia, Rentsch, Ronald, Restellini, Sophie, Richterich, Jean-Pierre, Rihs, Sylvia, Ritz, Marc Alain, Roduit, Jocelyn, Rogler, Daniela, Rogler, Gerhard, Rossel, Jean-Benoît, Rueger, Vanessa, Saner, Gaby, Sauter, Bernhard, Sawatzki, Mikael, Schäppi, Michela, Scharl, Michael, Scharl, Sylvie, Schelling, Martin, Schibli, Susanne, Schlauri, Hugo, Uebelhart, Sybille Schmid, Schnegg, Jean-François, Schoepfer, Alain, Seibold, Frank, Seirafi, Mariam, Semadeni, Gian-Marco, Semela, David, Senning, Arne, Sidler, Marc, Sokollik, Christiane, Spalinger, Johannes, Spangenberger, Holger, Stadler, Philippe, Steuerwald, Michael, Straumann, Alex, Straumann-Funk, Bigna, Sulz, Michael, Suter, Alexandra, Thorens, Joël, Tiedemann, Sarah, Tutuian, Radu, Vavricka, Stephan, Viani, Francesco, Vögtlin, Jürg, Von Känel, Roland, Vonlaufen, Alain, Vouillamoz, Dominique, Vulliamy, Rachel, Wermuth, Jürg, Werner, Helene, Wiesel, Paul, Wiest, Reiner, Wylie, Tina, Zeitz, Jonas, Zimmermann, Dorothee, Pittet, Valérie E.H., and Simonson, Thomas

Published
2019
Full Text
View/download PDF

5. Microbial network disturbances in relapsing refractory Crohn’s disease

Author

Yilmaz, Bahtiyar, Juillerat, Pascal, Øyås, Ove, Ramon, Charlotte, Bravo, Francisco Damian, Franc, Yannick, Fournier, Nicolas, Michetti, Pierre, Mueller, Christoph, Geuking, Markus, Pittet, Valerie E. H., Maillard, Michel H., Rogler, Gerhard, Swiss IBD Cohort Investigators, Wiest, Reiner, Stelling, Jörg, and Macpherson, Andrew J.

Published
2019
Full Text
View/download PDF

6. Symptoms of Depression and Anxiety Are Independently Associated With Clinical Recurrence of Inflammatory Bowel Disease

Author

Anderegg, Claudia, Bauerfeind, Peter, Beglinger, Christoph, Begré, Stefan, Belli, Dominique, Bengoa, José M., Biedermann, Luc, Bigler, Beat, Binek, Janek, Blattmann, Mirjam, Boehm, Stephan, Borovicka, Jan, Braegger, Christian P., Brunner, Nora, Bühr, Patrick, Burnand, Bernard, Burri, Emanuel, Buyse, Sophie, Cremer, Matthias, Criblez, Dominique H., de Saussure, Philippe, Degen, Lukas, Delarive, Joakim, Doerig, Christopher, Dora, Barbara, Dorta, Gian, Egger, Mara, Ehmann, Tobias, El-Wafa, Ali, Engelmann, Matthias, Ezri, Jessica, Felley, Christian, Fliegner, Markus, Fournier, Nicolas, Fraga, Montserrat, Frei, Pascal, Frei, Remus, Fried, Michael, Froehlich, Florian, Funk, Christian, Ivano Furlano, Raoul, Gallot-Lavallée, Suzanne, Geyer, Martin, Girardin, Marc, Golay, Delphine, Grandinetti, Tanja, Gysi, Beat, Haack, Horst, Haarer, Johannes, Helbling, Beat, Hengstler, Peter, Herzog, Denise, Hess, Cyrill, Heyland, Klaas, Hinterleitner, Thomas, Hiroz, Philippe, Hirschi, Claudia, Hruz, Petr, Iwata, Rika, Jost, Res, Juillerat, Pascal, Kessler Brondolo, Vera, Knellwolf, Christina, Knoblauch, Christoph, Köhler, Henrik, Koller, Rebekka, Krieger-Grübel, Claudia, Kullak-Ublick, Gerd, Künzler, Patrizia, Landolt, Markus, Lange, Rupprecht, Serge Lehmann, Frank, Macpherson, Andrew, Maerten, Philippe, Maillard, Michel H., Manser, Christine, Manz, Michael, Marbet, Urs, Marx, George, Matter, Christoph, McLin, Valérie, Meier, Rémy, Mendanova, Martina, Meyenberger, Christa, Michetti, Pierre, Misselwitz, Benjamin, Moradpour, Darius, Morell, Bernhard, Mosler, Patrick, Mottet, Christian, Müller, Christoph, Müller, Pascal, Müllhaupt, Beat, Münger-Beyeler, Claudia, Musso, Leilla, Nagy, Andreas, Neagu, Michaela, Nichita, Cristina, Niess, Jan, Noël, Natacha, Nydegger, Andreas, Obialo, Nicole, Oneta, Carl, Oropesa, Cassandra, Peter, Ueli, Peternac, Daniel, Marie Petit, Laetitia, Piccoli-Gfeller, Franziska, Beatrice Pilz, Julia, Pittet, Valérie, Raschle, Nadia, Rentsch, Ronald, Restellini, Sophie, Richterich, Jean-Pierre, Rihs, Sylvia, Alain Ritz, Marc, Roduit, Jocelyn, Rogler, Daniela, Rogler, Gerhard, Rossel, Jean-Benoît, Sagmeister, Markus, Saner, Gaby, Sauter, Bernhard, Sawatzki, Mikael, Schäppi, Michela, Scharl, Michael, Schelling, Martin, Schibli, Susanne, Schlauri, Hugo, Schmid Uebelhart, Sybille, Schnegg, Jean-François, Schoepfer, Alain, Seibold, Frank, Seirafi, Mariam, Semadeni, Gian-Marco, Semela, David, Senning, Arne, Sidler, Marc, Sokollik, Christiane, Spalinger, Johannes, Spangenberger, Holger, Stadler, Philippe, Steuerwald, Michael, Straumann, Alex, Straumann-Funk, Bigna, Sulz, Michael, Thorens, Joël, Tiedemann, Sarah, Tutuian, Radu, Vavricka, Stephan, Viani, Francesco, Vögtlin, Jürg, Von Känel, Roland, Vonlaufen, Alain, Vouillamoz, Dominique, Vulliamy, Rachel, Wermuth, Jürg, Werner, Helene, Wiesel, Paul, Wiest, Reiner, Wylie, Tina, Zeitz, Jonas, Zimmermann, Dorothee, Mikocka-Walus, Antonina, Pittet, Valerie, and von Känel, Roland

Published
2016
Full Text
View/download PDF

7. Alcohol and cannabis consumption in patients with inflammatory bowel disease: prevalence, pattern of consumption and impact on the disease

Author

Martinho-Grueber, Maude, primary, Kapoglou, Ioannis, additional, Bravo, Francisco, additional, Sarraj, Riad, additional, Benz, Eileen, additional, Restellini, Sophie, additional, Biedermann, Luc, additional, Rogler, Gerhard, additional, Vavricka, Stephan R., additional, Schoepfer, Alain, additional, Maillard, Michel H., additional, Michetti, Pierre, additional, Brunner, Felix, additional, Clair, Carole, additional, Barry, Mamadou Pathe, additional, Pittet, Valérie, additional, von Känel, Roland, additional, and Juillerat, Pascal, additional

Published
2022
Full Text
View/download PDF

9. The Relevance of Vitamin and Iron Deficiency in Patients with Inflammatory Bowel Diseases in Patients of the Swiss IBD Cohort

Author

Madanchi, Matiar, Fagagnini, Stefania, Fournier, Nicolas, Biedermann, Luc, Zeitz, Jonas, Battegay, Edouard, Zimmerli, Lukas, Vavricka, Stephan R, Rogler, Gerhard, Scharl, Michael, Anderegg, Claudia, Bauerfeind, Peter, Beglinger, Christoph, Begré, Stefan, Belli, Dominique, Bengoa, José M, Biedermann, Luc, Bigler, Beat, Binek, Janek, Blattmann, Mirjam, Boehm, Stephan, Borovicka, Jan, Braegger, Christian P, Brunner, Nora, Bühr, Patrick, Burnand, Bernard, Burri, Emanuel, Buyse, Sophie, Cremer, Matthias, Criblez, Dominique H, Saussure, Philippe de, Degen, Lukas, Delarive, Joakim, Doerig, Christopher, Dora, Barbara, Dorta, Gian, Egger, Mara, Ehmann, Tobias, El-Wafa, Ali, Engelmann, Matthias, Ezri, Jessica, Felley, Christian, Fliegner, Markus, Fournier, Nicolas, Fraga, Montserrat, Frei, Pascal, Frei, Remus, Fried, Michael, Froehlich, Florian, Funk, Christian, Furlano, Raoul Ivano, Gallot-Lavallée, Suzanne, Geyer, Martin, Girardin, Marc, Golay, Delphine, Grandinetti, Tanja, Gysi, Beat, Haack, Horst, Haarer, Johannes, Helbling, Beat, Hengstler, Peter, Herzog, Denise, Hess, Cyrill, Heyland, Klaas, Hinterleitner, Thomas, Hiroz, Philippe, Hirschi, Claudia, Hruz, Petr, Iwata, Rika, Jost, Res, Juillerat, Pascal, Brondolo, Vera Kessler, Knellwolf, Christina, Knoblauch, Christoph, Köhler, Henrik, Koller, Rebekka, Krieger-Grübel, Claudia, Kullak-Ublick, Gerd, Künzler, Patrizia, Landolt, Markus, Lange, Rupprecht, Lehmann, Frank Serge, Macpherson, Andrew, Maerten, Philippe, Maillard, Michel H, Manser, Christine, Manz, Michael, Marbet, Urs, Marx, George, Matter, Christoph, McLin, Valérie, Meier, Rémy, Mendanova, Martina, Meyenberger, Christa, Michetti, Pierre, Misselwitz, Benjamin, Moradpour, Darius, Morell, Bernhard, Mosler, Patrick, Mottet, Christian, Müller, Christoph, Müller, Pascal, Müllhaupt, Beat, Münger-Beyeler, Claudia, Musso, Leilla, Nagy, Andreas, Neagu, Michaela, Nichita, Cristina, Niess, Jan, Noël, Natacha, Nydegger, Andreas, Obialo, Nicole, Oneta, Carl, Oropesa, Cassandra, Peter, Ueli, Peternac, Daniel, Petit, Laetitia Marie, Piccoli-Gfeller, Franziska, Pilz, Julia Beatrice, Pittet, Valérie, Raschle, Nadia, Rentsch, Ronald, Restellini, Sophie, Richterich, Jean-Pierre, Rihs, Sylvia, Ritz, Marc Alain, Roduit, Jocelyn, Rogler, Daniela, Rogler, Gerhard, Rossel, Jean-Benoît, Sagmeister, Markus, Saner, Gaby, Sauter, Bernhard, Sawatzki, Mikael, Schäppi, Michela, Scharl, Michael, Schelling, Martin, Schibli, Susanne, Schlauri, Hugo, Uebelhart, Sybille Schmid, Schnegg, Jean-François, Schoepfer, Alain, Seibold, Frank, Seirafi, Mariam, Semadeni, Gian-Marco, Semela, David, Senning, Arne, Sidler, Marc, Sokollik, Christiane, Spalinger, Johannes, Spangenberger, Holger, Stadler, Philippe, Steuerwald, Michael, Straumann, Alex, Straumann-Funk, Bigna, Sulz, Michael, Thorens, Joël, Tiedemann, Sarah, Tutuian, Radu, Vavricka, Stephan, Viani, Francesco, Vögtlin, Jürg, Känel, Roland Von, Vonlaufen, Alain, Vouillamoz, Dominique, Vulliamy, Rachel, Wermuth, Jürg, Werner, Helene, Wiesel, Paul, Wiest, Reiner, Wylie, Tina, Zeitz, Jonas, and Zimmermann, Dorothee

Published
2018
Full Text
View/download PDF

10. Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohnʼs disease

Author

Lang, B. M., Biedermann, L., van Haaften, W. T., de Vallière, C., Schuurmans, M., Begré, S., Zeitz, J., Scharl, M., Turina, M., Greuter, T., Schreiner, P., Heinrich, H., Kuntzen, T., Vavricka, S. R., Rogler, G., Beerenwinkel, N., Misselwitz, B., Anderegg, Claudia, Bauerfeind, Peter, Beglinger, Christoph, Begré, Stefan, Bengoa, José M., Biedermann, Luc, Bigler, Beat, Binek, Janek, Blattmann, Mirjam, Boehm, Stephan, Borovicka, Jan, Braegger, Christian P., Brunner, Nora, Bühr, Patrick, Burnand, Bernard, Burri, Emanuel, Buyse, Sophie, Cremer, Matthias, Criblez, Dominique H., de Saussure, Philippe, Degen, Lukas, Delarive, Joakim, Doerig, Christopher, Dora, Barbara, Dorta, Gian, Egger, Mara, Ehmann, Tobias, El‐Wafa, Ali, Engelmann, Matthias, Ezri, a, Felley, Christian, Fliegner, Markus, Fournier, Nicolas, Fraga, Montserrat, Frei, Pascal, Frei, Remus, Fried, Michael, Froehlich, Florian, Funk, Christian, Furlano, Raoul Ivano, Gallot‐Lavallée, Suzanne, Geyer, Martin, Girardin, Marc, Golay, Delphine, Grandinetti, Tanja, Gysi, Beat, Haack, Horst, Haarer, Johannes, Helbling, Beat, Hengstler, Peter, Herzog, Denise, Hess, Cyrill, Heyland, Klaas, Hinterleitner, Thomas, Hiroz, Philippe, Hirschi, Claudia, Hruz, Petr, Iwata, Rika, Jost, Res, Juillerat, Pascal, Kessler Brondolo, Vera, Knellwolf, Christina, Knoblauch, Christoph, Köhler, Henrik, Koller, Rebekka, Krieger‐Grübel, Claudia, Kullak‐Ublick, Gerd, Künzler, Patrizia, Landolt, Markus, Lange, Rupprecht, Lehmann, Frank Serge, Macpherson, Andrew, Maerten, Philippe, Maillard, Michel H., Manser, Christine, Manz, Michael, Marbet, Urs, Marx, George, Matter, Christoph, McLin, Valérie, Meier, Rémy, Mendanova, Martina, Meyenberger, Christa, Michetti, Pierre, Misselwitz, Benjamin, Moradpour, Darius, Morell, Bernhard, Mosler, Patrick, Mottet, Christian, Müller, Christoph, Müller, Pascal, Müllhaupt, Beat, Münger‐Beyeler, Claudia, Musso, Leilla, Nagy, Andreas, Neagu, Michaela, Nichita, Cristina, Niess, Jan, Noël, Natacha, Nydegger, Andreas, Obialo, Nicole, Oneta, Carl, Oropesa, Cassandra, Peter, Ueli, Peternac, Daniel, Petit, Laetitia Marie, Piccoli‐Gfeller, Franziska, Pilz, Julia Beatrice, Pittet, Valérie, Raschle, Nadia, Rentsch, Ronald, Restellini, Sophie, Richterich, Jean‐Pierre, Rihs, Sylvia, Ritz, Marc Alain, Roduit, Jocelyn, Rogler, Daniela, Rogler, Gerhard, Rossel, Jean‐Benoît, Sagmeister, Markus, Saner, Gaby, Sauter, Bernhard, Sawatzki, Mikael, Schäppi, Michela, Scharl, Michael, Schelling, Martin, Schibli, Susanne, Schlauri, Hugo, Uebelhart, Sybille Schmid, Schnegg, Jean‐François, Schoepfer, Alain, Seibold, Frank, Seirafi, Mariam, Semadeni, Gian‐Marco, Semela, David, Senning, Arne, Sidler, Marc, Sokollik, Christiane, Spalinger, Johannes, Spangenberger, Holger, Stadler, Philippe, Steuerwald, Michael, Straumann, Alex, Straumann‐Funk, Bigna, Sulz, Michael, Thorens, Joël, Tiedemann, Sarah, Tutuian, Radu, Vavricka, Stephan, Viani, Francesco, Vögtlin, Jürg, Von Känel, Roland, Vonlaufen, Alain, Vouillamoz, Dominique, Vulliamy, Rachel, Wermuth, Jürg, Werner, Helene, Wiesel, Paul, Wiest, Reiner, Wylie, Tina, Zeitz, Jonas, and Zimmermann, Dorothee

Published
2018
Full Text
View/download PDF

12. Sa1634: PREVALENCE AND IMPACT OF ALCOHOL CONSUMPTION AND CANNABIS USE ON INFLAMMATORY BOWEL DISEASES

Author

Martinho-Grueber, Maude, primary, Kapoglou, Ioannis, additional, Bravo, Francisco, additional, Sarraj, Riad, additional, Benz, Eileen, additional, Restellini, Sophie, additional, Biedermann, Luc, additional, Rogler, Gerhard, additional, Vavricka, Stephan R., additional, Schoepfer, Alain M., additional, Maillard, Michel H., additional, Michetti, Pierre F., additional, Brunner, Felix, additional, Clair, Carole, additional, Barry, Mamadou Pathe, additional, Känel, Roland Von, additional, and Juillerat, Pascal, additional

Published
2022
Full Text
View/download PDF

13. 1178 PROMISING EFFICACY OF SMALL MOLECULES AND BIOLOGICALS FOR MICROSCOPIC COLITIS: RESULTS FROM A LARGE REAL-LIFE MULTICENTER COHORT

Author

Verstockt, Bram, Taelman, Thibault, Vavricka, Stephan R., Zabana, Yamile, Lenfant, Matthias, Macaigne, Gilles, Maillard, Michel H., Savarino, Edoardo, Teich, Niels, Kiudelis, Vytautas, De La Revilla Negro, Juan, Ribaldone, Davide Giuseppe, Barreiro-De-Acosta, Manuel, Wildt, Signe, Rivière, Pauline, Fumery, Mathurin, Truyens, Marie, Amiot, Aurelien, Marsal, Jan, Levartovsky, Asaf, Vieujean, Sophie, Somers, Michaël, Cremer, Anneline, Lyutakov, Ivan, Cohen, Nathaniel A., De Wit, Sophie, Bajer, Lukas, Rahier, Jean-Francois, Backman, Ann-Sofie, Nancey, Stephane, Choden, Tenzin, Van Dongen, Jurgen, Munch, Andreas, and Julsgaard, Mette

Published
2024
Full Text
View/download PDF

14. Primary Hypogammaglobulinaemia with Inflammatory Bowel Disease-Like Features: An ECCO CONFER Multicentre Case Series

Author

MS MDL 1, Infection & Immunity, Albshesh, Ahmad, Eder, Piotr, Ribaldone, Davide Giuseppe, Oldenburg, Bas, de Boer, Nanne K, Mantzaris, Gerassimos J, Savarino, Edoardo Vincenzo, Dragoni, Gabriele, Weisshof, Roni, Truyens, Marie, Festa, Stefano, Maillard, Michel H, Capirchio, Lena, Filip, Rafal, Theodoraki, Eirini, Kopylov, Uri, MS MDL 1, Infection & Immunity, Albshesh, Ahmad, Eder, Piotr, Ribaldone, Davide Giuseppe, Oldenburg, Bas, de Boer, Nanne K, Mantzaris, Gerassimos J, Savarino, Edoardo Vincenzo, Dragoni, Gabriele, Weisshof, Roni, Truyens, Marie, Festa, Stefano, Maillard, Michel H, Capirchio, Lena, Filip, Rafal, Theodoraki, Eirini, and Kopylov, Uri

Published
2022

15. Effectiveness of golimumab in patients with ulcerative colitis: results of a real-life study in Switzerland

Author

Perrig, Kathrin; https://orcid.org/0000-0002-8730-954X, Krupka, Niklas, Jordi, Sebastian Bruno Ulrich, Rossel, Jean-Benoît, Biedermann, Luc; https://orcid.org/0000-0003-0824-4125, Greuter, Thomas, Schreiner, Philipp, Vavricka, Stephan R, Juillerat, Pascal, Burri, Emanuel, Zimmermann, Dorothee, Maillard, Michel H, Sulz, Michael Christian, Brand, Stephan, Rogler, Gerhard, Misselwitz, Benjamin, Perrig, Kathrin; https://orcid.org/0000-0002-8730-954X, Krupka, Niklas, Jordi, Sebastian Bruno Ulrich, Rossel, Jean-Benoît, Biedermann, Luc; https://orcid.org/0000-0003-0824-4125, Greuter, Thomas, Schreiner, Philipp, Vavricka, Stephan R, Juillerat, Pascal, Burri, Emanuel, Zimmermann, Dorothee, Maillard, Michel H, Sulz, Michael Christian, Brand, Stephan, Rogler, Gerhard, and Misselwitz, Benjamin

Abstract

Background: Tumor necrosis factor (TNF) inhibitors have improved treatment of ulcerative colitis (UC), but loss of response remains a frequent problem. The anti-TNF agent, golimumab, was approved in Switzerland for the treatment of UC in 2014. This study aims to summarize the experience of golimumab in a real-world setting in Switzerland. Methods: We analyzed real-world data from 1769 UC patients from the Swiss Inflammatory Bowel Disease Cohort (SIBDC) study and performed a chart review of golimumab-treated patients. We extracted the partial Mayo score at t0 (baseline), t1 (2-16 weeks), t2 (17-35 weeks), and t3 (36-89 weeks). The primary endpoint was clinical response at t1, defined as marked improvement in partial Mayo score and objective parameters. Clinical remission was defined as resolution of symptoms and normalization of objective parameters. Results: Our chart review included 103 UC patients with golimumab treatment (5.8% of all SIBDC UC patients); only 16 (15.5%) were anti-TNF naïve. Sixty-three patients remained on golimumab (61.2%) after 180 days, 51 (44.7%) after 365 days, and 34 (33%) after 630 days after the start of treatment. Upon golimumab treatment, the partial Mayo score decreased from 4 [interquartile range (IQR): 2-6] at t0 to 2 (IQR: 0-4) at t1, 1 (IQR: 0-3.5) at t2, and 1 (IQR: 0-3) at t3 (p < 0.001 for all comparisons with t0). The primary endpoint, clinical response at t1, could be evaluated in 52 patients and was met in 15 individuals (28.8%). Clinical remission at t1 was observed in 8 out of 52 patients (15.4%). Golimumab was generally well tolerated, one patient developed meningitis. The most frequent reasons to stop treatment were primary and secondary non-response. Conclusion: Golimumab was used in 5.8% of Swiss UC patients, mainly in biologic-experienced individuals. Golimumab treatment was associated with a sustained reduction of symptoms and clinical response in approximately 30% of patients.[ClinicalTrials.gov identifier: NCT0048863

Published
2022

17. Effectiveness of golimumab in patients with ulcerative colitis: results of a real-life study in Switzerland

Author

Perrig, Kathrin, primary, Krupka, Niklas, additional, Jordi, Sebastian Bruno Ulrich, additional, Rossel, Jean-Benoît, additional, Biedermann, Luc, additional, Greuter, Thomas, additional, Schreiner, Philipp, additional, Vavricka, Stephan R., additional, Juillerat, Pascal, additional, Burri, Emanuel, additional, Zimmermann, Dorothee, additional, Maillard, Michel H., additional, Sulz, Michael Christian, additional, Brand, Stephan, additional, Rogler, Gerhard, additional, and Misselwitz, Benjamin, additional

Published
2022
Full Text
View/download PDF

18. Primary Hypogammaglobulinaemia with Inflammatory Bowel Disease-Like Features: An ECCO CONFER Multicentre Case Series

Author

Albshesh, Ahmad, primary, Eder, Piotr, additional, Ribaldone, Davide Giuseppe, additional, Oldenburg, Bas, additional, de Boer, Nanne K, additional, Mantzaris, Gerassimos J, additional, Savarino, Edoardo Vincenzo, additional, Dragoni, Gabriele, additional, Weisshof, Roni, additional, Truyens, Marie, additional, Festa, Stefano, additional, Maillard, Michel H, additional, Capirchio, Lena, additional, Filip, Rafal, additional, Theodoraki, Eirini, additional, and Kopylov, Uri, additional

Published
2021
Full Text
View/download PDF

19. Primary hypogammaglobulinemia with IBD-like features: An ECCO CONFER Multicenter Case Series

Author

Albshesh, Ahmad, Eder, Piotr, Ribaldone, Davide Giuseppe, Oldenburg, Bas, de Boer, Nanne K, Mantzaris, Gerassimos J, Savarino, Edoardo Vincenzo, Dragoni, Gabriele, Weisshof, Roni, Truyens, Marie, Festa, Stefano, Maillard, Michel H, Capirchio, Lena, Filip, Rafal, Theodoraki, Eirini, and Kopylov, Uri

Subjects
inflammatory bowel disease, IBD-like features, primary hypogammaglobulinemia, immunodeficiency
Published
2021

20. Primary hypogammaglobulinemia with IBD-like features: An ECCO CONFER Multicenter Case Series.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de gastro-entérologie, Albshesh, Ahmad, Eder, Piotr, Ribaldone, Davide Giuseppe, Oldenburg, Bas, de Boer, Nanne K, Mantzaris, Gerassimos J, Savarino, Edoardo Vincenzo, Dragoni, Gabriele, Weisshof, Roni, Truyens, Marie, Festa, Stefano, Maillard, Michel H, Capirchio, Lena, Filip, Rafal, Theodoraki, Eirini, Kopylov, Uri, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de gastro-entérologie, Albshesh, Ahmad, Eder, Piotr, Ribaldone, Davide Giuseppe, Oldenburg, Bas, de Boer, Nanne K, Mantzaris, Gerassimos J, Savarino, Edoardo Vincenzo, Dragoni, Gabriele, Weisshof, Roni, Truyens, Marie, Festa, Stefano, Maillard, Michel H, Capirchio, Lena, Filip, Rafal, Theodoraki, Eirini, and Kopylov, Uri

Abstract

Hypogammaglobulinemia is a disorder characterized by low serum immunoglobulin levels and had high prevalence of gastrointestinal manifestations. In some cases, clinical and endoscopic features are indistinguishable from those of inflammatory bowel disease (IBD). This was a multicenter case series performed as a part of the European Crohn's and Colitis Organisation (ECCO) Collaborative Network of Exceptionally Rare case reports (CONFER) project. This report includes 27 patients with primary hypogammaglobulinemia and IBD-like features [20 males and 7 females, median age 45.6 years (Interquartile range (IQR) 35.2-59]. Crohn's disease-like features were noted in 23 patients, four patients had ulcerative colitis-like features. The diagnosis of hypogammaglobulinemia preceded IBD-like features diagnosis in 20 patients (median of 7 years prior, IQR 2.6-20.6 years), and followed IBD-like features appearance in 7 cases (median of one year after, IQR 0.45-5.6 years).Hypogammaglobulinemia etiologies were common variable immunodeficiency (66.6%), agammaglobulinemia (7.4%), selective IgA-deficiency (11.1%), Goods syndrome (7.4%), IgG subclass deficiency with IgA deficiency (3.7%) and hyper-IgM (3.7%). In addition to antibiotics and intravenous immunoglobulin (IVIG) for hypogammaglobulinemia, 12 patients received IBD-related treatment including 5-ASA (2 patients), corticosteroids (1 patient), thiopurines (3 patients), anti-TNFs (4 patients) and vedolizumab (2 patients). By the end of the follow-up [44.5 months (IQR 18-81)], 21/27 (77%) patients were in clinical remission. This case series describes IBD-like features in patients with hypogammaglobulinemia. The diagnosis of IBD-like features mainly occurred after that of hypogammaglobulinemia, with successful recovery in the majority of cases after appropriate treatment.

Published
2021

21. Symptoms of Depression and Anxiety Are Independently Associated With Clinical Recurrence of Inflammatory Bowel Disease

Author

Mikocka-Walus, Antonina, Pittet, Valerie, Rossel, Jean-Benoît, von Känel, Roland, Anderegg, Claudia, Bauerfeind, Peter, Beglinger, Christoph, Begré, Stefan, Belli, Dominique, Bengoa, José M., Biedermann, Luc, Bigler, Beat, Binek, Janek, Blattmann, Mirjam, Boehm, Stephan, Borovicka, Jan, Braegger, Christian P., Brunner, Nora, Bühr, Patrick, Burnand, Bernard, Burri, Emanuel, Buyse, Sophie, Cremer, Matthias, Criblez, Dominique H., de Saussure, Philippe, Degen, Lukas, Delarive, Joakim, Doerig, Christopher, Dora, Barbara, Dorta, Gian, Egger, Mara, Ehmann, Tobias, El-Wafa, Ali, Engelmann, Matthias, Ezri, Jessica, Felley, Christian, Fliegner, Markus, Fournier, Nicolas, Fraga, Montserrat, Frei, Pascal, Frei, Remus, Fried, Michael, Froehlich, Florian, Funk, Christian, Ivano Furlano, Raoul, Gallot-Lavallée, Suzanne, Geyer, Martin, Girardin, Marc, Golay, Delphine, Grandinetti, Tanja, Gysi, Beat, Haack, Horst, Haarer, Johannes, Helbling, Beat, Hengstler, Peter, Herzog, Denise, Hess, Cyrill, Heyland, Klaas, Hinterleitner, Thomas, Hiroz, Philippe, Hirschi, Claudia, Hruz, Petr, Iwata, Rika, Jost, Res, Juillerat, Pascal, Kessler Brondolo, Vera, Knellwolf, Christina, Knoblauch, Christoph, Köhler, Henrik, Koller, Rebekka, Krieger-Grübel, Claudia, Kullak-Ublick, Gerd, Künzler, Patrizia, Landolt, Markus, Lange, Rupprecht, Serge Lehmann, Frank, Macpherson, Andrew, Maerten, Philippe, Maillard, Michel H., Manser, Christine, Manz, Michael, Marbet, Urs, Marx, George, Matter, Christoph, McLin, Valérie, Meier, Rémy, Mendanova, Martina, Meyenberger, Christa, Michetti, Pierre, Misselwitz, Benjamin, Moradpour, Darius, Morell, Bernhard, Mosler, Patrick, Mottet, Christian, Müller, Christoph, Müller, Pascal, Müllhaupt, Beat, Münger-Beyeler, Claudia, Musso, Leilla, Nagy, Andreas, Neagu, Michaela, Nichita, Cristina, Niess, Jan, Noël, Natacha, Nydegger, Andreas, Obialo, Nicole, Oneta, Carl, Oropesa, Cassandra, Peter, Ueli, Peternac, Daniel, Marie Petit, Laetitia, Piccoli-Gfeller, Franziska, Beatrice Pilz, Julia, Pittet, Valérie, Raschle, Nadia, Rentsch, Ronald, Restellini, Sophie, Richterich, Jean-Pierre, Rihs, Sylvia, Alain Ritz, Marc, Roduit, Jocelyn, Rogler, Daniela, Rogler, Gerhard, Rossel, Jean-Benoît, Sagmeister, Markus, Saner, Gaby, Sauter, Bernhard, Sawatzki, Mikael, Schäppi, Michela, Scharl, Michael, Schelling, Martin, Schibli, Susanne, Schlauri, Hugo, Schmid Uebelhart, Sybille, Schnegg, Jean-François, Schoepfer, Alain, Seibold, Frank, Seirafi, Mariam, Semadeni, Gian-Marco, Semela, David, Senning, Arne, Sidler, Marc, Sokollik, Christiane, Spalinger, Johannes, Spangenberger, Holger, Stadler, Philippe, Steuerwald, Michael, Straumann, Alex, Straumann-Funk, Bigna, Sulz, Michael, Thorens, Joël, Tiedemann, Sarah, Tutuian, Radu, Vavricka, Stephan, Viani, Francesco, Vögtlin, Jürg, Von Känel, Roland, Vonlaufen, Alain, Vouillamoz, Dominique, Vulliamy, Rachel, Wermuth, Jürg, Werner, Helene, Wiesel, Paul, Wiest, Reiner, Wylie, Tina, Zeitz, Jonas, and Zimmermann, Dorothee

Published
2016
Full Text
View/download PDF

22. Effects of anti-TNF therapy and immunomodulators on anxiety and depressive symptoms in patients with inflammatory bowel disease: a 5-year analysis

Author

Siebenhüner, Alexander R., primary, Rossel, Jean-Benoît, additional, Schreiner, Philipp, additional, Butter, Matthias, additional, Greuter, Thomas, additional, Krupka, Niklas, additional, Jordi, Sebastian B. U., additional, Biedermann, Luc, additional, Rogler, Gerhard, additional, Misselwitz, Benjamin, additional, von Känel, Roland, additional, Abdelrahman, Karim, additional, Ademi, Gentiana, additional, Aepli, Patrick, additional, Thomas, Amman, additional, Anderegg, Claudia, additional, Antonino, Anca-Teodora, additional, Archanioti, Eva, additional, Arrigoni, Eviano, additional, Aslan, Nurullah, additional, Bakker de Jong, Diana, additional, Balsiger, Bruno, additional, Barry, Mamadou-Pathé, additional, Bastürk, Polat, additional, Bauerfeind, Peter, additional, Becocci, Andrea, additional, Bengoa, José M., additional, Binek, Janek, additional, Blattmann, Mirjam, additional, Boehm, Stephan, additional, Boldanova, Tujana, additional, Borovicka, Jan, additional, Braegger, Christian P., additional, Brand, Stephan, additional, Bravo, Francisco, additional, Brügger, Lukas, additional, Brunner, Simon, additional, Bühr, Patrick, additional, Burk, Sabine, additional, Burri, Emanuel, additional, Buyse, Sophie, additional, Cao, Dahlia-Thao, additional, Carstens, Ove, additional, Criblez, Dominique H., additional, D’Angelo, Fabrizia, additional, Saussure, Philippe de, additional, Degen, Lukas, additional, Delarive, Joakim, additional, Doerig, Christopher, additional, Dora, Barbara, additional, Drerup, Susan, additional, Ducrey, Carole, additional, El-Wafa, Ali, additional, Engelmann, Matthias, additional, Erdmann-Voisin, Aude, additional, Felley, Christian, additional, Fliegner, Markus, additional, Fraga, Montserrat, additional, Franc, Yannick, additional, Frei, Pascal, additional, Frei, Remus, additional, Fried, Michael, additional, Froehlich, Florian, additional, Ivano Furlano, Raoul, additional, Garzoni, Luca, additional, Geyer, Martin, additional, Girardin, Marc, additional, Golay, Delphine, additional, Good, Ignaz, additional, Graf Bigler, Ulrike, additional, Godat, Sébastien, additional, Gysi, Beat, additional, Haarer, Johannes, additional, Halama, Marcel, additional, Haldemann, Janine, additional, Heer, Pius, additional, Heimgartner, Benjamin, additional, Helbling, Beat, additional, Hengstler, Peter, additional, Herzog, Denise, additional, Hess, Cyrill, additional, Hessler, Roxane, additional, Heyland, Klaas, additional, Hinterleitner, Thomas, additional, Hirschi, Claudia, additional, Hruz, Petr, additional, Juillerat, Pascal, additional, Kapoglou, Ioannis, additional, Kayser, Stephan, additional, Keller, Céline, additional, Khalid-de Bakker, Carolina, additional, Knellwolf, Christina, additional, Knoblauch, Christoph, additional, Köhler, Henrik, additional, Koller, Rebekka, additional, Krieger, Claudia, additional, Künzler, Patrizia, additional, Kusche, Rachel, additional, Serge Lehmann, Frank, additional, Macpherson, Andrew, additional, Maillard, Michel H., additional, Manz, Michael, additional, Martinho, Maude, additional, Meier, Rémy, additional, Meyenberger, Christa, additional, Meyer, Pamela, additional, Michetti, Pierre, additional, Morell, Bernhard, additional, Mosler, Patrick, additional, Moschouri, Eleni, additional, Mottet, Christian, additional, Müller, Christoph, additional, Müllhaupt, Beat, additional, Musso, Leilla, additional, Neagu, Michaela, additional, Nichita, Cristina, additional, Niess, Jan, additional, Nydegger, Andreas, additional, Obialo, Nicole, additional, Oropesa, Cassandra, additional, Peter, Ulrich, additional, Peternac, Daniel, additional, Marie Petit, Laetitia, additional, Pittet, Valérie, additional, Pohl, Daniel, additional, Porzner, Marc, additional, Preissler, Claudia, additional, Raschle, Nadia, additional, Rentsch, Ronald, additional, Restellini, Sophie, additional, Richterich, Jean-Pierre, additional, Riedmüller, Sandra, additional, Risti, Branislav, additional, Alain Ritz, Marc, additional, Röhrich, Nina, additional, Roth, René, additional, Rueger, Vanessa, additional, Sagmeister, Markus, additional, Saner, Gaby, additional, Sarraj, Riad, additional, Sauter, Bernhard, additional, Sawatzki, Mikael, additional, Scharl, Michael, additional, Scharl, Sylvie, additional, Schelling, Martin, additional, Schibli, Susanne, additional, Schlauri, Hugo, additional, Schluckebier, Dominique, additional, Schmid, Daniela, additional, Schmid, Sybille, additional, Schnegg, Jean-François, additional, Schoepfer, Alain, additional, Seibold, Frank, additional, Seirafi, Mariam, additional, Semadeni, Gian-Marco, additional, Senning, Arne, additional, Sokollik, Christiane, additional, Sommer, Joachim, additional, Spalinger, Johannes, additional, Spangenberger, Holger, additional, Stadler, Philippe, additional, Staub, Peter, additional, Staudenmann, Dominic, additional, Stenz, Volker, additional, Steuerwald, Michael, additional, Straumann, Alex, additional, Stulz, Andreas, additional, Sulz, Michael, additional, Tempia-Caliera, Michela, additional, Thorens, Joël, additional, Truninger, Kaspar, additional, Tutuian, Radu, additional, Urfer, Patrick, additional, Vavricka, Stephan, additional, Viani, Francesco, additional, Vinzens, Fabrizion, additional, Vögtlin, Jürg, additional, Von Känel, Roland, additional, Vouillamoz, Dominique, additional, Vulliamy, Rachel, additional, Vullièmoz, Marianne, additional, Wiesel, Paul, additional, Wiest, Reiner, additional, Wöhrle, Stefanie, additional, Yilmaz, Bahtiyar, additional, Zamora, Samuel, additional, Zander, Silvan, additional, Zeitz, Jonas, additional, and Zimmermann, Dorothee, additional

Published
2021
Full Text
View/download PDF

23. Varicella Zoster Virus in Inflammatory Bowel Disease Patients: What Every Gastroenterologist Should Know

Author

Schreiner, Philipp, primary, Mueller, Nicolas J, additional, Fehr, Jan, additional, Maillard, Michel H, additional, Brand, Stephan, additional, Michetti, Pierre, additional, Schoepfer, Alain, additional, Restellini, Sophie, additional, Vulliemoz, Marianne, additional, Vavricka, Stephan R, additional, Juillerat, Pascal, additional, Rogler, Gerhard, additional, and Biedermann, Luc, additional

Published
2020
Full Text
View/download PDF

26. Primary Hypogammaglobulinaemia with Inflammatory Bowel Disease-Like Features: An ECCO CONFER Multicentre Case Series.

Author

Albshesh, Ahmad, Eder, Piotr, Ribaldone, Davide Giuseppe, Oldenburg, Bas, Boer, Nanne K de, Mantzaris, Gerassimos J, Savarino, Edoardo Vincenzo, Dragoni, Gabriele, Weisshof, Roni, Truyens, Marie, Festa, Stefano, Maillard, Michel H, Capirchio, Lena, Filip, Rafal, Theodoraki, Eirini, and Kopylov, Uri

Abstract

Background Hypogammaglobulinaemia is a disorder characterized by low serum immunoglobulin levels and a high prevalence of gastrointestinal manifestations. In some cases, clinical and endoscopic features are indistinguishable from those of inflammatory bowel disease [IBD]. Methods This was a multicentre case series performed as a part of the European Crohn's and Colitis Organisation [ECCO] Collaborative Network of Exceptionally Rare case reports [CONFER] project. Results This report includes 27 patients with primary hypogammaglobulinaemia and IBD-like features: 20 males and seven females, median age 45.6 years (interquartile range [IQR] 35.2–59). Crohn's disease-like features were noted in 23 patients, and four patients had ulcerative colitis-like features. The diagnosis of hypogammaglobulinaemia preceded a diagnosis of IBD-like features in 20 patients [median of 7 years prior, IQR 2.6–20.6 years], and followed the appearance of IBD-like features in seven cases [median of 1 year after, IQR 0.45–5.6 years]. Hypogammaglobulinaemia aetiologies were common variable immunodeficiency [66.6%], agammaglobulinaemia [7.4%], selective IgA-deficiency [11.1%], Good's syndrome [7.4%], IgG subclass deficiency with IgA deficiency [3.7%] and hyper-IgM [3.7%]. In addition to antibiotics and intravenous immunoglobulin [IVIG] for hypogammaglobulinaemia, 12 patients received IBD-related treatment including 5-aminosalicylate agents [two patients], corticosteroids [one patient], thiopurines [three patients], anti-tumour necrosis factor [four patients] and vedolizumab [two patients]. By the end of the follow-up (44.5 months [IQR 18–81]), 21/27 [77%] patients were in clinical remission. Conclusion This case series describes IBD-like features in patients with hypogammaglobulinaemia. The diagnosis of IBD-like features mainly occurred after that of hypogammaglobulinaemia, with successful recovery in the majority of cases after appropriate treatment. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

28. High Immunogenicity of the Pneumococcal Conjugated Vaccine in Immunocompromised Adults With Inflammatory Bowel Disease

Author

Pittet, Laure, Verolet, Charlotte, Michetti, Pierre, Girardin, Marc, Juillerat, Pascal, Mottet, Christian, Maillard, Michel H, Siegrist, Claire-Anne, Posfay Barbe, Klara, and Swiss Inflammatory Bowel Disease Cohort Study Group

Subjects
Male, medicine.medical_treatment, Pneumococcal Vaccines/administration & dosage/immunology, Immunomodulation/immunology, Inflammatory bowel disease, Pneumococcal Vaccines, 0302 clinical medicine, Vaccines, Conjugate/administration & dosage/immunology, 610 Medicine & health, ddc:616, ddc:618, Immunogenicity, Vaccination, Gastroenterology, Inflammatory Bowel Diseases/drug therapy/immunology, Immunosuppression, Middle Aged, Pneumococcal infections, Treatment Outcome, Underlying disease, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Female, Patient Safety, Immunosuppressive Agents, Switzerland, Adult, Risk Assessment, Pneumococcal Infections, Immunomodulation, 03 medical and health sciences, Immunocompromised Host, medicine, Humans, Vaccination/methods, Pneumococcal Infections/prevention & control, Analysis of Variance, Vaccines, Conjugate, Hepatology, business.industry, medicine.disease, Inflammatory Bowel Diseases, digestive system diseases, Clinical trial, Multicenter study, Immunology, Linear Models, Immunosuppressive Agents/therapeutic use, business
Abstract

INTRODUCTION Patients with inflammatory bowel disease (IBD) are predisposed to pneumococcal infections due to their underlying disease and iatrogenic immunosuppression. Vaccination with the 13-valent pneumococcal conjugated vaccine (PCV13) is recommended, but with poor take-up and few data available. We performed an open-label, phase IV, multicenter study to evaluate the safety and immunogenicity of PCV13 in adults with IBD and to analyze the influence of immunomodulating treatments on anti-pneumococcal seroresponses. METHODS We enrolled 306 patients with IBD from March 2014 through February 2016, with the following exclusion criteria: current IBD flare, pregnancy, pneumococcal immunization in the previous 5 years, and influenza immunization in the previous 4 weeks. PCV13 was administered intramuscularly. Serotype-specific vaccine responses were evaluated using an opsonophagocytic assay. Adverse events were monitored by diary cards and standardized phone interviews. RESULTS The median seroprotection rate increased significantly from 43.9% (95% confidence interval [CI], 42.3-45.5) at inclusion to 90.4% (95% CI, 89.5-91.3%; P < 0.001) after vaccination. Patients receiving anti-tumor necrosis factor agents achieved a slightly lower seroprotection rate (from 44.5% [95% CI, 42.3%-46.8%] to 86.6% [95% CI, 84.9%-88.1%]) than patients treated with other types of immunosuppressive regimens (thiopurine, methotrexate, oral corticosteroids; from 44.7% [95% CI, 41.7%-47.7%] to 93.8% [95% CI, 92.1%-95.2%]) or nonimmunosuppressive treatment (5-aminosalicylate, topical corticosteroids, vedolizumab; from 41.3% [95% CI, 37.9%-44.8%] to 95.2% [95% CI, 93.4%-96.6%]). There were no safety issues. DISCUSSION Overall, the administration of PCV13 was highly immunogenic and well tolerated, irrespective of the baseline treatment, and should be encouraged in all adults with IBD.

Published
2019

29. Publisher Correction: Microbial network disturbances in relapsing refractory Crohn's disease

Author

Yilmaz, Bahtiyar, Juillerat, Pascal, Øyås, Ove, Ramon, Charlotte, Bravo, Francisco Damian, Franc, Yannick, Fournier, Nicolas, Michetti, Pierre, Mueller, Christoph, Geuking, Markus, Pittet, Valerie E H, Maillard, Michel H, Rogler, Gerhard, Swiss IBD Cohort Investigators, Wiest, Reiner, Stelling, Jörg, Macpherson, Andrew J, University of Zurich, and Macpherson, Andrew J

Subjects
10219 Clinic for Gastroenterology and Hepatology, 10036 Medical Clinic, 1300 General Biochemistry, Genetics and Molecular Biology, 610 Medicine & health
Published
2019

30. Position statement on the use of biosimilars in inflammatory bowel disease

Author

Burri, Emanuel, Juillerat, Pascal; https://orcid.org/0000-0002-0947-5235, Maillard, Michel H, Manz, Michael, Michetti, Pierre; https://orcid.org/0000-0003-4982-7327, Mottet, Christian, Rogler, Gerhard; https://orcid.org/0000-0002-1733-9188, Zahnd, Nadine, Vavricka, Stephan, Burri, Emanuel, Juillerat, Pascal; https://orcid.org/0000-0002-0947-5235, Maillard, Michel H, Manz, Michael, Michetti, Pierre; https://orcid.org/0000-0003-4982-7327, Mottet, Christian, Rogler, Gerhard; https://orcid.org/0000-0002-1733-9188, Zahnd, Nadine, and Vavricka, Stephan

Abstract

Biologics are effective and have a good safety profile in the treatment of inflammatory bowel disease. Biosimilars have recently become available as treatment option. They are biological agents that are highly similar to the original biologic compound in their structure, biological activity, efficacy and safety. This position paper summarises current knowledge on biosimilars and presents its statements on regulatory issues and clinical situation in order to provide clinicians adequate information for them to reach informed and appropriate shared decision-making with their patients.

Published
2019

31. Risk of Vaccine-Preventable Infections in Swiss Adults with Inflammatory Bowel Disease.

Author

Pittet, Laure F., Verolet, Charlotte M., Michetti, Pierre, Gaillard, Elsa, Girardin, Marc, Juillerat, Pascal, Mottet, Christian, Maillard, Michel H., Siegrist, Claire-Anne, and Posfay-Barbe, Klara M.

Subjects
INFLAMMATORY bowel diseases, CROHN'S disease, BOOSTER vaccines, PREVENTIVE medicine, TICK-borne encephalitis
Abstract

Background: Patients with inflammatory bowel disease (IBD) have a higher risk of infection and are frequently not up to date with their immunizations. Objectives: This study aims to review vaccination status and evaluate whether age, disease type, or treatment regimen could predict the absence of seroprotection against selected vaccine-preventable infection in adults with IBD. Methods: Cross-sectional study using questionnaire, immunization records review, and assessment of tetanus-specific, varicella-specific, and measles-specific immunoglobulin G concentrations. ClinicalTrials.gov: NCT01908283. Results: Among the 306 adults assessed (median age 42.7 years old, 70% with Crohn's disease, 78% receiving immunosuppressive treatment), only 33% had an immunization record available. Absence of seroprotection against tetanus (6%) was associated with increasing age and absence of booster dose; absence of seroprotection against varicella (1%) or measles (3%) was exclusively observed in younger patients with Crohn's disease. There was no statistically significant difference in immunoglobulin concentrations among treatment groups. Although vaccinations are strongly recommended in IBD patients, the frequencies of participants with at least 1 dose of vaccine recorded were low for nearly all antigens: tetanus 94%, diphtheria 87%, pertussis 54%, poliovirus 22%, measles-mumps-rubella 47%, varicella-zoster 0%, Streptococcus pneumoniae 5%, Neisseria meningitidis 12%, hepatitis A 41%, hepatitis B 48%, human papillomavirus 5%, and tick-borne encephalitis 6%. Conclusions: Although many guidelines recommend the vaccination of IBD patients, disease prevention through immunization is still often overlooked, including in Switzerland, increasing their risk of vaccine-preventable diseases. Serological testing should be standardized to monitor patients' protection during follow-up as immunity may wane faster in this population. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

32. Differences in Outcomes Reported by Patients With Inflammatory Bowel Diseases vs Their Health Care Professionals

Author

Pittet, Valérie E.H., primary, Maillard, Michel H., additional, Simonson, Thomas, additional, Fournier, Nicolas, additional, Rogler, Gerhard, additional, Michetti, Pierre, additional, Anderegg, Claudia, additional, Bauerfeind, Peter, additional, Beglinger, Christoph, additional, Begré, Stefan, additional, Belli, Dominique, additional, Bengoa, José M., additional, Biedermann, Luc, additional, Bigler, Beat, additional, Binek, Janek, additional, Blattmann, Mirjam, additional, Boehm, Stephan, additional, Borovicka, Jan, additional, Braegger, Christian P., additional, Brunner, Nora, additional, Bühr, Patrick, additional, Burnand, Bernard, additional, Burri, Emanuel, additional, Buyse, Sophie, additional, Cremer, Matthias, additional, Criblez, Dominique H., additional, de Saussure, Philippe, additional, Degen, Lukas, additional, Delarive, Joakim, additional, Doerig, Christopher, additional, Dora, Barbara, additional, Dorta, Gian, additional, Egger, Mara, additional, Ehmann, Tobias, additional, El-Wafa, Ali, additional, Engelmann, Matthias, additional, Ezri, Jessica, additional, Felley, Christian, additional, Fliegner, Markus, additional, Fraga, Montserrat, additional, Frei, Pascal, additional, Frei, Remus, additional, Fried, Michael, additional, Froehlich, Florian, additional, Funk, Christian, additional, Furlano, Raoul Ivano, additional, Gallot-Lavallée, Suzanne, additional, Geyer, Martin, additional, Girardin, Marc, additional, Golay, Delphine, additional, Grandinetti, Tanja, additional, Gysi, Beat, additional, Haack, Horst, additional, Haarer, Johannes, additional, Helbling, Beat, additional, Hengstler, Peter, additional, Herzog, Denise, additional, Hess, Cyrill, additional, Heyland, Klaas, additional, Hinterleitner, Thomas, additional, Hiroz, Philippe, additional, Hirschi, Claudia, additional, Hruz, Petr, additional, Iwata, Rika, additional, Jost, Res, additional, Juillerat, Pascal, additional, Keller, Céline, additional, Knellwolf, Christina, additional, Knoblauch, Christoph, additional, Köhler, Henrik, additional, Koller, Rebekka, additional, Krieger-Grübel, Claudia, additional, Kullak-Ublick, Gerd, additional, Künzler, Patrizia, additional, Landolt, Markus, additional, Lange, Rupprecht, additional, Lehmann, Frank Serge, additional, Macpherson, Andrew, additional, Maerten, Philippe, additional, Manser, Christine, additional, Manz, Michael, additional, Marbet, Urs, additional, Marx, George, additional, Matter, Christoph, additional, Meier, Rémy, additional, Mendanova, Martina, additional, Misselwitz, Benjamin, additional, Morell, Bernhard, additional, Mosler, Patrick, additional, Mottet, Christian, additional, Müller, Christoph, additional, Müller, Pascal, additional, Müllhaupt, Beat, additional, Münger-Beyeler, Claudia, additional, Musso, Leilla, additional, Nagy, Andreas, additional, Neagu, Michaela, additional, Nichita, Cristina, additional, Niess, Jan, additional, Nydegger, Andreas, additional, Obialo, Nicole, additional, Oneta, Carl, additional, Oropesa, Cassandra, additional, Peter, Ueli, additional, Peternac, Daniel, additional, Petit, Laetitia Marie, additional, Piccoli-Gfeller, Franziska, additional, Pilz, Julia Beatrice, additional, Pittet, Valérie, additional, Raschle, Nadia, additional, Rentsch, Ronald, additional, Restellini, Sophie, additional, Richterich, Jean-Pierre, additional, Rihs, Sylvia, additional, Ritz, Marc Alain, additional, Roduit, Jocelyn, additional, Rogler, Daniela, additional, Rossel, Jean-Benoît, additional, Rueger, Vanessa, additional, Saner, Gaby, additional, Sauter, Bernhard, additional, Sawatzki, Mikael, additional, Schäppi, Michela, additional, Scharl, Michael, additional, Scharl, Sylvie, additional, Schelling, Martin, additional, Schibli, Susanne, additional, Schlauri, Hugo, additional, Uebelhart, Sybille Schmid, additional, Schnegg, Jean-François, additional, Schoepfer, Alain, additional, Seibold, Frank, additional, Seirafi, Mariam, additional, Semadeni, Gian-Marco, additional, Semela, David, additional, Senning, Arne, additional, Sidler, Marc, additional, Sokollik, Christiane, additional, Spalinger, Johannes, additional, Spangenberger, Holger, additional, Stadler, Philippe, additional, Steuerwald, Michael, additional, Straumann, Alex, additional, Straumann-Funk, Bigna, additional, Sulz, Michael, additional, Suter, Alexandra, additional, Thorens, Joël, additional, Tiedemann, Sarah, additional, Tutuian, Radu, additional, Vavricka, Stephan, additional, Viani, Francesco, additional, Vögtlin, Jürg, additional, Von Känel, Roland, additional, Vonlaufen, Alain, additional, Vouillamoz, Dominique, additional, Vulliamy, Rachel, additional, Wermuth, Jürg, additional, Werner, Helene, additional, Wiesel, Paul, additional, Wiest, Reiner, additional, Wylie, Tina, additional, Zeitz, Jonas, additional, and Zimmermann, Dorothee, additional

Published
2019
Full Text
View/download PDF

33. Uveitis manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study

Author

Biedermann, Luc, primary, Renz, Laura, additional, Fournier, Nicolas, additional, Rossel, Jean-Benoît, additional, Butter, Matthias, additional, Bluemel, Sena, additional, Vavricka, Stephan R., additional, Rogler, Gerhard, additional, Scharl, Michael, additional, Anderegg, Claudia, additional, Bauerfeind, Peter, additional, Beglinger, Christoph, additional, Begré, Stefan, additional, Belli, Dominique, additional, Bengoa, José M., additional, Biedermann, Luc, additional, Bigler, Beat, additional, Binek, Janek, additional, Blattmann, Mirjam, additional, Boehm, Stephan, additional, Borovicka, Jan, additional, Braegger, Christian P., additional, Brunner, Nora, additional, Bühr, Patrick, additional, Burnand, Bernard, additional, Burri, Emanuel, additional, Buyse, Sophie, additional, Cremer, Matthias, additional, Criblez, Dominique H., additional, Saussure, Philippe de, additional, Degen, Lukas, additional, Delarive, Joakim, additional, Doerig, Christopher, additional, Dora, Barbara, additional, Dorta, Gian, additional, Egger, Mara, additional, Ehmann, Tobias, additional, El-Wafa, Ali, additional, Engelmann, Matthias, additional, Ezri, Jessica, additional, Felley, Christian, additional, Fliegner, Markus, additional, Fraga, Montserrat, additional, Frei, Pascal, additional, Frei, Remus, additional, Fried, Michael, additional, Froehlich, Florian, additional, Funk, Christian, additional, Ivano Furlano, Raoul, additional, Gallot-Lavallée, Suzanne, additional, Geyer, Martin, additional, Girardin, Marc, additional, Golay, Delphine, additional, Grandinetti, Tanja, additional, Gysi, Beat, additional, Haack, Horst, additional, Haarer, Johannes, additional, Helbling, Beat, additional, Hengstler, Peter, additional, Herzog, Denise, additional, Hess, Cyrill, additional, Heyland, Klaas, additional, Hinterleitner, Thomas, additional, Hiroz, Philippe, additional, Hirschi, Claudia, additional, Hruz, Petr, additional, Iwata, Rika, additional, Jost, Res, additional, Juillerat, Pascal, additional, Kessler Brondolo, Vera, additional, Knellwolf, Christina, additional, Knoblauch, Christoph, additional, Köhler, Henrik, additional, Koller, Rebekka, additional, Krieger-Grübel, Claudia, additional, Kullak-Ublick, Gerd, additional, Künzler, Patrizia, additional, Landolt, Markus, additional, Lange, Rupprecht, additional, Serge Lehmann, Frank, additional, Macpherson, Andrew, additional, Maerten, Philippe, additional, Maillard, Michel H., additional, Manser, Christine, additional, Manz, Michael, additional, Marbet, Urs, additional, Marx, George, additional, Matter, Christoph, additional, McLin, Valérie, additional, Meier, Rémy, additional, Mendanova, Martina, additional, Meyenberger, Christa, additional, Michetti, Pierre, additional, Misselwitz, Benjamin, additional, Moradpour, Darius, additional, Morell, Bernhard, additional, Mosler, Patrick, additional, Mottet, Christian, additional, Müller, Christoph, additional, Müller, Pascal, additional, Müllhaupt, Beat, additional, Münger-Beyeler, Claudia, additional, Musso, Leilla, additional, Nagy, Andreas, additional, Neagu, Michaela, additional, Nichita, Cristina, additional, Niess, Jan, additional, Noël, Natacha, additional, Nydegger, Andreas, additional, Obialo, Nicole, additional, Oneta, Carl, additional, Oropesa, Cassandra, additional, Peter, Ueli, additional, Peternac, Daniel, additional, Marie Petit, Laetitia, additional, Piccoli-Gfeller, Franziska, additional, Beatrice Pilz, Julia, additional, Pittet, Valérie, additional, Raschle, Nadia, additional, Rentsch, Ronald, additional, Restellini, Sophie, additional, Richterich, Jean-Pierre, additional, Rihs, Sylvia, additional, Alain Ritz, Marc, additional, Roduit, Jocelyn, additional, Rogler, Daniela, additional, Sagmeister, Markus, additional, Saner, Gaby, additional, Sauter, Bernhard, additional, Sawatzki, Mikael, additional, Schäppi, Michela, additional, Schelling, Martin, additional, Schibli, Susanne, additional, Schlauri, Hugo, additional, Schmid Uebelhart, Sybille, additional, Schnegg, Jean-François, additional, Schoepfer, Alain, additional, Seibold, Frank, additional, Seirafi, Mariam, additional, Semadeni, Gian-Marco, additional, Semela, David, additional, Senning, Arne, additional, Sidler, Marc, additional, Sokollik, Christiane, additional, Spalinger, Johannes, additional, Spangenberger, Holger, additional, Stadler, Philippe, additional, Steuerwald, Michael, additional, Straumann, Alex, additional, Straumann-Funk, Bigna, additional, Sulz, Michael, additional, Thorens, Joël, additional, Tiedemann, Sarah, additional, Tutuian, Radu, additional, Vavricka, Stephan, additional, Viani, Francesco, additional, Vögtlin, Jürg, additional, Von Känel, Roland, additional, Vonlaufen, Alain, additional, Vouillamoz, Dominique, additional, Vulliamy, Rachel, additional, Wermuth, Jürg, additional, Werner, Helene, additional, Wiesel, Paul, additional, Wiest, Reiner, additional, Wylie, Tina, additional, Zeitz, Jonas, additional, and Zimmermann, Dorothee, additional

Published
2019
Full Text
View/download PDF

34. Varicella Zoster Virus in Inflammatory Bowel Disease Patients: What Every Gastroenterologist Should Know.

Author

Schreiner, Philipp, Mueller, Nicolas J, Fehr, Jan, Maillard, Michel H, Brand, Stephan, Michetti, Pierre, Schoepfer, Alain, Restellini, Sophie, Vulliemoz, Marianne, Vavricka, Stephan R, Juillerat, Pascal, Rogler, Gerhard, and Biedermann, Luc

Abstract

Primary varicella zoster virus [VZV] infection results in varicella [chickenpox] and its reactivation results in herpes zoster [HZ; shingles]. Patients with inflammatory bowel disease [IBD] are susceptible to complications of primary VZV infection and have an increased risk of HZ. Concerns of VZV and HZ infection in the IBD population have been highlighted by the emergence of JAK inhibitors and their safety profile in this patient population, as with tofacitinib for the treatment of ulcerative colitis [UC]. The current pipeline of emerging therapies includes novel molecules targeting multiple pathways, including JAK/signal transducer and cytokine signalling pathways, such as JAK/STAT. Hence VZV and HZ will be increasingly relevant for gastroenterologists treating IBD patients in light of these emerging therapies. This review will focus on the epidemiology, disease course, prevention, and management of these two distinct infections in patients with IBD. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

36. Treatment Algorithm for Mild and Moderate-to-Severe Ulcerative Colitis: An Update.

Author

Burri, Emanuel, Maillard, Michel H., Schoepfer, Alain M., Seibold, Frank, Van Assche, Gert, Rivière, Pauline, Laharie, David, and Manz, Michael

Subjects
*ULCERATIVE colitis, *ALGORITHMS, *INDIVIDUALIZED medicine, *SMALL molecules, *MEDICAL protocols
Abstract

Background: Patient care in ulcerative colitis (UC) remains challenging despite an array of established treatment options and emerging new therapies. The management of UC therapy should be guided by the endoscopic extent of inflammation, disease severity, and prognostic factors of poor outcome. Complete remission, defined as durable symptomatic and endoscopic remission without corticosteroid therapy, is the desired treatment goal. Summary: This review focuses on treatment recommendations for different clinical scenarios in moderate-to-severe UC: Active UC of any extent not responding to aminosalicylates, steroid-dependent UC, steroid-refractory UC, immunomodulator-refractory UC, and acute severe UC. Comprehensive treatment algorithms for daily clinical practice were developed based on published guidelines and current literature. Key Messages: While current treatment options including a number of biologicals and small molecules have evolved UC treatment to achieve sustained remission in a majority of patients, upcoming treatment options with different molecular pathways and different modes of actions will further increase the need for personalized medicine. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

37. Vaccination in Patients with Inflammatory Bowel Diseases.

Author

Manser, Christine N., Maillard, Michel H., Rogler, Gerhard, Schreiner, Philipp, Rieder, Florian, and Bühler, Silja

Subjects
*INFLAMMATORY bowel diseases, *VACCINATION, *COMMUNICABLE diseases, *CROHN'S disease, *PSORIATIC arthritis
Abstract

During the course of disease, a majority of inflammatory bowel disease (IBD) patients requires long-term immunosuppressive therapy with either immunomodulatory agents, biologics, or newer immunosuppressive therapies such as Vedolizumab, a selective α4β7 inhibitor, Ustekinumab, an IL 12/23 p40 inhibitor, or the Janus kinase inhibitor Tofacitinib. Due to this, they are at increased risk for infectious diseases, many of which are possible to prevent by vaccination. This review focuses on recommended vaccinations in IBD patients and stresses special issues which have to be paid attention to. The aim of the review is to increase gastroenterologists' awareness of the importance of vaccination and to stress why especially the gastroenterologist should assess the vaccination status of the patient and initiate vaccination as soon as diagnosis is established. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

38. Therapeutic Drug Monitoring to Guide Clinical Decision Making in Inflammatory Bowel Disease Patients with Loss of Response to Anti-TNF: A Delphi Technique-Based Consensus.

Author

Greuter, Thomas, Maillard, Michel H., Juillerat, Pascal, Michetti, Pierre, Seibold, Frank, Mottet, Christian, Zahnd, Nadine, Sauter, Bernhard, Schoepfer, Alain M., Rogler, Gerhard, and Vavricka, Stephan R.

Subjects
*INFLAMMATORY bowel diseases, *DRUG monitoring, *DECISION making, *CROHN'S disease, *ULCERATIVE colitis
Abstract

Background: Loss of response is frequently encountered in patients with inflammatory bowel disease (IBD) treated with antitumor necrosis factor (TNF) agents. Therapeutic drug monitoring (TDM) and antidrug antibody measurement are increasingly used in this setting. Methods: To establish a consensus on the use of TDM in the context of loss of response to anti-TNFs, we performed a vote using a Delphi-style process followed by an expert panel discussion among 8 IBD specialists practicing in Switzerland, Europe. Statements were rated on an even Likert-scale ranging from 1 (strong disagreement) to 4 (strong agreement), based on expert opinion and the available literature. Results: The experts agreed on the following statements: (i) loss of response is associated with inadequate drug levels in both Crohn's disease and ulcerative colitis; (ii) best timepoint for measuring drug levels is prior to the next application (= trough levels) with different thresholds for anti-TNF agents (infliximab 5 μg/mL, adalimumab 8 μg/mL, certolizumab pegol 10 μg/mL); (iii) antidrug antibodies are predictive for loss of response; and (iv) antidrug-antibody titers and drug trough levels are key determinants in the treatment algorithm. Data about non-anti-TNF biologics were considered too limited to propose recommendations. Conclusion: A Delphi-style consensus among 8 IBD experts shows that TDM and measurement of antidrug-antibody titers are useful in the context of loss of response to anti-TNF. Optimal cutoff levels depend on the type of anti-TNF. These values are critical in the decision making process. More studies are needed to address the value of such measurements for non-anti-TNF biologics. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

39. Mise au point sur la rectocolite ulcéro-hémorragique en 2017

Author

Moschouri, Eleni, primary, Hessler, Roxane, additional, Pittet, Valérie, additional, Velin, Dominique, additional, Conrad, Curdin, additional, Hahnloser, Dieter, additional, Gié, Olivier, additional, Michetti, Pierre, additional, Schoepfer, Alain M., additional, and Maillard, Michel H., additional

Published
2017
Full Text
View/download PDF

40. Evolution of Health Care Utilisation and Costs for Inflammatory Bowel Disease Over Ten Years.

Author

Pillai, Nadia, Dusheiko, Mark, Maillard, Michel H, Rogler, Gerhard, Brüngger, Beat, Bähler, Caroline, Pittet, Valérie E H, and Group, Swiss IBD Cohort Study

Abstract

Background and Aims Inflammatory bowel disease [IBD] places an economic strain on health systems due to expensive pharmaceutical therapy, risk of hospitalisation and surgery, and long-term monitoring. The evolving treatment guidelines advocate rapid scale-up to biologic agents in order to improve health outcomes and quality of life. This study evaluated changes in health care utilisation and expenditures for IBD in Switzerland over time. Methods We extracted clinical, patient, and resource consumption data from the Swiss IBD Cohort Study between 2006 and 2016. Average unit costs for IBD-related events were derived from Swiss claims data and pharmaceutical price lists. We used multivariate regression, controlling for patient-level characteristics, to estimate trends and determinants of direct and indirect costs and resource utilisation. Results We included 2365 adults diagnosed with Crohn's disease [CD; N = 1353] and ulcerative colitis [UC; N = 1012]. From 2006–16, mean health care expenditures per patient per year were 9504 euros [70% drugs, 23% inpatient, 7% outpatient] for CD and 5704 euros [68% drugs, 22% inpatient, 10% outpatient] for UC. Health care costs increased by 7% [CD] and 10% [UC] per year, largely due to rising pharmaceutical expenditures driven by increased biologic agent use. Inpatient, outpatient, and indirect costs fluctuated and did not offset increased pharmaceutical costs. Disease characteristics were important predictors of costs. Conclusions Increased expenditure for IBD was marked by a shift towards greater pharmaceutical management over the past decade. This study highlights the need to identify cost-effective treatment strategies in the face of increased uptake and expenditures associated with innovative treatments. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

41. Information needs and concerns of patients with inflammatory bowel disease: what can we learn from participants in a bilingual clinical cohort?

Author

Pittet, Valérie, Vaucher, Carla, Maillard, Michel H, Girardin, Marc, de Saussure, Philippe, Burnand, Bernard, Rogler, Gerhard, Michetti, Pierre, Pittet, Valérie, Vaucher, Carla, Maillard, Michel H, Girardin, Marc, de Saussure, Philippe, Burnand, Bernard, Rogler, Gerhard, and Michetti, Pierre

Abstract

BACKGROUND Inflammatory Bowel Disease (IBD) patients are confronted with needs and concerns related to their disease. AIM To explore information expectations of patients included in a national bilingual IBD cohort in Switzerland (SIBDC). METHODS This is a mixed-methods study, comprising 1) a semi-narrative survey sent to 1506 patients from the SIBDC and 2) two focus groups conducted with 14 patients to explore and assess the relevance of the survey's findings. Data collected within the framework of the SIBDC was used to characterize survey's responders. RESULTS 728 patients (48%) replied to the survey: 52.5% females, 56% Crohn's disease (CD), 87% secondary/tertiary level educated, 70% full/part-time employed. On average, 47% of patients sought for information, regardless of the disease stage; 27% of them were dissatisfied with information received at the time of first symptoms. During flares, 43% were concerned about drugs and therapies; in remission, 57% had concerns on research and developments; 27% searched for information linked to daily disease management. Information-seeking increased when active disease, for CD with high levels of perceived stress (OR = 2.47; p = 0.003), and for all with higher posttraumatic stress symptoms. The focus groups confirmed a perceived lack of information about general functioning, disease course, treatments and their risks, extra-intestinal symptoms and manifestations. CONCLUSIONS Information remains insufficient for IBD patients. Lack of information in specific domains can potentially cause stress and hinder detection of symptoms. Better information should be considered as a potentially important component in improving patients' outcomes in IBD.

Published
2016

42. Appropriateness and long-term discontinuation rate of biological therapies in ulcerative colitis

Author

Maillard, Michel H, Bortolotti, Murielle, Vader, John-Paul, Mottet, Christian, Schöpfer, Alain, Gonvers, Jean-Jacques, Burnand, Bernard, Froehlich, Florian, Michetti, Pierre, Pittet, Valérie, Juillerat, Pascal, Tutuian, Radu, and Swiss Inflammatory Bowel Diseases Cohort Study Group, The

Subjects
610 Medicine & health
Abstract

BACKGROUND Anti-TNFα agents are commonly used for ulcerative colitis (UC) therapy in the event of non-response to conventional strategies or as colon-salvaging therapy. The objectives were to assess the appropriateness of biological therapies for UC patients and to study treatment discontinuation over time, according to appropriateness of treatment, as a measure of outcome. METHODS We selected adult ulcerative colitis patients from the Swiss IBD cohort who had been treated with anti-TNFα agents. Appropriateness of the first-line anti-TNFα treatment was assessed using detailed criteria developed during the European Panel on the Appropriateness of Therapy for UC. Treatment discontinuation as an outcome was assessed for categories of appropriateness. RESULTS Appropriateness of the first-line biological treatment was determined in 186 UC patients. For 64% of them, this treatment was considered appropriate. During follow-up, 37% of all patients discontinued biological treatment, 17% specifically because of failure. Time-to-failure of treatment was significantly different among patients on an appropriate biological treatment compared to those for whom the treatment was considered not appropriate (p=0.0007). Discontinuation rate after 2years was 26% compared to 54% between those two groups. Patients on inappropriate biological treatment were more likely to have severe disease, concomitant steroids and/or immunomodulators. They were also consistently more likely to suffer a failure of efficacy and to stop therapy during follow-up. CONCLUSION Appropriateness of first-line anti-TNFα therapy results in a greater likelihood of continuing with the therapy. In situations where biological treatment is uncertain or inappropriate, physicians should consider other options instead of prescribing anti-TNFα agents.

Published
2014
Full Text
View/download PDF

46. Patient-reported healthcare expectations in inflammatory bowel diseases.

Author

Pittet, Valérie, Vaucher, Carla, Froehlich, Florian, Maillard, Michel H., Michetti, Pierre, and null, null

Subjects
INFLAMMATORY bowel diseases, INFLAMMATORY bowel disease treatment, PATIENT satisfaction, MEDICAL care, MULTIVARIATE analysis, PATIENTS
Abstract

Background: Patient-reported experience is an important component of a holistic approach to quality of care. Patients’ expectations of treatments and global disease management may indicate their illness representations and their satisfaction and hopes regarding quality of care. Objective: To study expectations of patients with inflammatory bowel disease. Methods: Two focus groups were conducted with 14 patients to explore their expectations about treatments and disease management. From qualitative content analyses of focus group discussions, we built a 22-item expectations questionnaire that was sent to 1756 patients of the Swiss IBD cohort. Answers were collected on a visual analog scale from 0 to 100, and medians (interquartile range [IQR]) calculated. Factor analysis identified main expectation dimensions, and multivariate analyses were performed to describe associations with patient characteristics. Results: Of 1094 patients (62%) included in the study, 54% were female, 54% had Crohn’s disease, 35% had tertiary education, and 72% were employed. Expectation dimensions comprised realistic, predictive, and ideal expectations and were linked to information, communication, daily care, and disease recognition. Half (11 of 22) of the expectations were ranked as very high (median score > 70), the 2 most important being good coordination between general practitioners and specialists (median score: 89, IQR: 71–96) and information on treatment adverse events (89, IQR: 71–96). Women had overall higher levels of expectations than did men. Expectations were not associated with psychosocial measures, except those related to disease recognition, and most of them were highly associated with increased concerns on disease constraints and uncertainty. Conclusions: Patients have high expectations for information and communication among caregivers, the levels varying by gender and region. Patients also appear to request more active participation in their disease management. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

49. Epithelial NAIPs protect against colonic tumorigenesis

Author

Allam, Ramanjaneyulu, primary, Maillard, Michel H., additional, Tardivel, Aubry, additional, Chennupati, Vijaykumar, additional, Bega, Hristina, additional, Yu, Chi Wang, additional, Velin, Dominique, additional, Schneider, Pascal, additional, and Maslowski, Kendle M., additional

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results