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1. Erratum: Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA). [World J Emerg Surg. 11, (2016) (33)] DOI: 10.1186/s13017-016-0089-y

Author

Sartelli, M, Weber, DG, Ruppé, E, Bassetti, M, Wright, BJ, Ansaloni, L, Catena, F, Coccolini, F, Abu-Zidan, FM, Coimbra, R, Moore, EE, Moore, FA, Maier, RV, De Waele, JJ, Kirkpatrick, AW, Griffiths, EA, Eckmann, C, Brink, AJ, Mazuski, JE, May, AK, Sawyer, RG, Mertz, D, Montravers, P, Kumar, A, Roberts, JA, Vincent, JL, Watkins, RR, Lowman, W, Spellberg, B, Abbott, IJ, Adesunkanmi, AK, Al-Dahir, S, Al-Hasan, MN, Agresta, F, Althani, AA, Ansari, S, Ansumana, R, Augustin, G, Bala, M, Balogh, ZJ, Baraket, O, Bhangu, A, Beltrán, MA, Bernhard, M, Biffl, WL, Boermeester, MA, Brecher, SM, Cherry-Bukowiec, JR, Buyne, OR, Cainzos, MA, Cairns, KA, Camacho-Ortiz, A, Chandy, SJ, Che Jusoh, A, Chichom-Mefire, A, Colijn, C, Corcione, F, Cui, Y, Curcio, D, Delibegovic, S, Demetrashvili, Z, De Simone, B, Dhingra, S, Diaz, JJ, Di Carlo, I, Dillip, A, Di Saverio, S, Doyle, MP, Dorj, G, Dogjani, A, Dupont, H, Eachempati, SR, Enani, MA, Egiev, VN, Elmangory, MM, Ferrada, P, Fitchett, JR, Fraga, GP, Guessennd, N, Giamarellou, H, Ghnnam, W, Gkiokas, G, Goldberg, SR, Gomes, CA, Gomi, H, Guzmán-Blanco, M, Haque, M, Hansen, S, Hecker, A, Heizmann, WR, Herzog, T, Hodonou, AM, Hong, SK, Kafka-Ritsch, R, Kaplan, LJ, Kapoor, G, Karamarkovic, A, Kees, MG, Kenig, J, and Kiguba, R

Subjects
Surgery
Abstract

© The Author(s). The original article [1] contains an error whereby a co-author, Boris Sakakushev has their family name spelt incorrectly as 'Sakakhushev'. The authors would therefore like it known that the correct spelling of the family name is 'Sakakushev'.

Published
2017

2. Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author

Sartelli, M, Weber, DG, Ruppé, E, Bassetti, M, Wright, BJ, Ansaloni, L, Catena, F, Coccolini, F, Abu-Zidan, FM, Coimbra, R, Moore, EE, Moore, FA, Maier, RV, De Waele, JJ, Kirkpatrick, AW, Griffiths, EA, Eckmann, C, Brink, AJ, Mazuski, JE, May, AK, Sawyer, RG, Mertz, D, Montravers, P, Kumar, A, Roberts, JA, Vincent, JL, Watkins, RR, Lowman, W, Spellberg, B, Abbott, IJ, Adesunkanmi, AK, Al-Dahir, S, Al-Hasan, MN, Agresta, F, Althani, AA, Ansari, S, Ansumana, R, Augustin, G, Bala, M, Balogh, ZJ, Baraket, O, Bhangu, A, Beltrán, MA, Bernhard, M, Biffl, WL, Boermeester, MA, Brecher, SM, Cherry-Bukowiec, JR, Buyne, OR, Cainzos, MA, Cairns, KA, Camacho-Ortiz, A, Chandy, SJ, Che Jusoh, A, Chichom-Mefire, A, Colijn, C, Corcione, F, Cui, Y, Curcio, D, Delibegovic, S, Demetrashvili, Z, De Simone, B, Dhingra, S, Diaz, JJ, Di Carlo, I, Dillip, A, Di Saverio, S, Doyle, MP, Dorj, G, Dogjani, A, Dupont, H, Eachempati, SR, Enani, MA, Egiev, VN, Elmangory, MM, Ferrada, P, Fitchett, JR, Fraga, GP, Guessennd, N, Giamarellou, H, Ghnnam, W, Gkiokas, G, Goldberg, SR, Gomes, CA, Gomi, H, Guzmán-Blanco, M, Haque, M, Hansen, S, Hecker, A, Heizmann, WR, Herzog, T, Hodonou, AM, Hong, SK, Kafka-Ritsch, R, Kaplan, LJ, Kapoor, G, Karamarkovic, A, Kees, MG, Kenig, J, and Kiguba, R

Subjects
Anti-Infective Agents, International Cooperation, Humans, Intraabdominal Infections, Surgery, Drug Resistance, Microbial, Microbial Sensitivity Tests, Prognosis
Abstract

© 2016 The Author(s). Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2016

3. 2016 WSES guidelines on acute calculous cholecystitis

Author

Ansaloni, L, Pisano, M, Coccolini, F, Peitzmann, AB, Fingerhut, A, Catena, F, Agresta, F, Allegri, A, Bailey, I, Balogh, ZJ, Bendinelli, C, Biffl, W, Bonavina, L, Borzellino, G, Brunetti, F, Burlew, CC, Camapanelli, G, Campanile, FC, Ceresoli, M, Chiara, O, Civil, I, Coimbra, R, De Moya, M, Di Saverio, S, Fraga, GP, Gupta, S, Kashuk, J, Kelly, MD, Koka, V, Jeekel, H, Latifi, R, Leppaniemi, A, Maier, RV, Marzi, I, Moore, F, Piazzalunga, D, Sakakushev, B, Sartelli, M, Scalea, T, Stahel, PF, Taviloglu, K, Tugnoli, G, Uraneus, S, Velmahos, GC, Wani, I, Weber, DG, Viale, P, Sugrue, M, Ivatury, R, Kluger, Y, Gurusamy, KS, Moore, EE, Ansaloni, L, Pisano, M, Coccolini, F, Peitzmann, AB, Fingerhut, A, Catena, F, Agresta, F, Allegri, A, Bailey, I, Balogh, ZJ, Bendinelli, C, Biffl, W, Bonavina, L, Borzellino, G, Brunetti, F, Burlew, CC, Camapanelli, G, Campanile, FC, Ceresoli, M, Chiara, O, Civil, I, Coimbra, R, De Moya, M, Di Saverio, S, Fraga, GP, Gupta, S, Kashuk, J, Kelly, MD, Koka, V, Jeekel, H, Latifi, R, Leppaniemi, A, Maier, RV, Marzi, I, Moore, F, Piazzalunga, D, Sakakushev, B, Sartelli, M, Scalea, T, Stahel, PF, Taviloglu, K, Tugnoli, G, Uraneus, S, Velmahos, GC, Wani, I, Weber, DG, Viale, P, Sugrue, M, Ivatury, R, Kluger, Y, Gurusamy, KS, and Moore, EE

Abstract

Acute calculus , is a very common disease with several area of uncertainty. The World Society of Emergency Surgery developed extensive guidelines in order to cover grey areas. The diagnostic criteria, the antimicrobial therapy, the evaluation of associated common bile duct stones, the identification of "high risk" patients, the surgical timing, the type of surgery, and the alternatives to surgery are discussed. Moreover the algorithm is proposed: as soon as diagnosis is made and after the evaluation of choledocholitiasis risk, laparoscopic cholecystectomy should be offered to all patients exception of those with high risk of morbidity or mortality. These Guidelines must be considered as an adjunctive tool for decision but they are not substitute of the clinical judgement for the individual patient.

Published
2016

4. Prostaglandin E2 production by endotoxin-stimulated alveolar macrophages is regulated by phospholipase C pathways

Author

Chong-Jeh Lo, Henry G. Cryer, and Maier Rv

Subjects
Lipopolysaccharides, Male, medicine.medical_specialty, medicine.medical_treatment, Multiple Organ Failure, Phospholipase, Dinoprostone, Manoalide, chemistry.chemical_compound, Internal medicine, Macrophages, Alveolar, medicine, Animals, Prostaglandin E2, Phospholipase C, business.industry, Molecular biology, Endocrinology, chemistry, Type C Phospholipases, Second messenger system, lipids (amino acids, peptides, and proteins), Arachidonic acid, Rabbits, business, Eicosanoid Production, Prostaglandin E, medicine.drug, Signal Transduction
Abstract

Background : Eicosanoids play an important role in many aspects of systemic inflammatory responses and host defense. Although the synthesis of eicosanoids by different enzymes has been elucidated, the regulatory mechanism of eicosanoid production is not clear. We designed this study to investigate the hypothesis that PGE 2 production by endotoxin (lipopolysaccharide; LPS)-stimulated macrophages (M ?) is dependent on phospholipase C (PLC) signaling pathways. Methods : Rabbit alveolar macrophages (M ?) were obtained by bronchoalveolar lavage. M ? were suspended in RPMI-1640 medium at 1 x 10 6 /mL and were exposed to Escherichia coli LPS (10 ng/mL) ± various agonists and antagonists of PLC and its secondary messengers. After 24 hours of incubation, prostaglandin E 2 (PGE 2 ) production was measured by ELISA. Results : LPS-activated M ? produced four times as much PGE 2 as did control unstimulated M ?. The increase in PGE 2 production was inhibited by PLC inhibitors (U73122 or D609) and a low-molecular-weight PLA 2 inhibitor, manoalide. An increase in intracellular calcium and activation of both the calmodulin and protein kinase C kinase pathways increase PGE 2 production. Conclusions : PGE 2 production is intimately dependent on several phospholipases. Production is not only dependent on low-molecular-weight PLA 2 cleavage of arachidonic acid from membrane phospholipids, but also by-products of PLC activation. PLC-dependent intracellular Ca-calmodulin signaling and protein kinase C activation provide significant modulation of PGE 2 production.

Published
1996

7. Characterization of acute coagulopathy and sexual dimorphism after injury: females and coagulopathy just do not mix.

Author

Brown JB, Cohen MJ, Minei JP, Maier RV, West MA, Billiar TR, Peitzman AB, Moore EE, Cuschieri J, Sperry JL, Inflammation and the Host Response to Injury Investigators, Brown, Joshua B, Cohen, Mitchell J, Minei, Joseph P, Maier, Ronald V, West, Michael A, Billiar, Timothy R, Peitzman, Andrew B, Moore, Ernest E, and Cuschieri, Joseph

Published
2012
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31. Relationship between trauma center volume and outcomes.

Author

Nathens AB, Jurkovich GJ, Maier RV, Grossman DC, MacKenzie EJ, Moore M, Rivara FP, Nathens, A B, Jurkovich, G J, Maier, R V, Grossman, D C, MacKenzie, E J, Moore, M, and Rivara, F P

Abstract

Context: The premise underlying regionalization of trauma care is that larger volumes of trauma patients cared for in fewer institutions will lead to improved outcomes. However, whether a relationship exists between institutional volume and trauma outcomes remains unknown.Objective: To evaluate the association between trauma center volume and outcomes of trauma patients.Design: Retrospective cohort study.Setting: Thirty-one academic level I or level II trauma centers across the United States participating in the University Healthsystem Consortium Trauma Benchmarking Study.Patients: Consecutive patients with penetrating abdominal injury (PAI; n = 478) discharged between November 1, 1997, and July 31, 1998, or with multisystem blunt trauma (minimum of head injury and lower-extremity long-bone fractures; n = 541) discharged between June 1 and December 31, 1998.Main Outcome Measures: Inpatient mortality and hospital length of stay (LOS), comparing high-volume (>650 trauma admissions/y) and low-volume (Results: After multivariate adjustment for patient characteristics and injury severity, the relative odds of death was 0.02 (95% confidence interval [CI], 0.002-0.25) for patients with PAI admitted with shock to high-volume centers compared with low-volume centers. No benefit was evident in patients without shock (P =.50). The adjusted odds of death in patients with multisystem blunt trauma who presented with coma to a high-volume center was 0.49 (95% CI, 0.26-0.93) vs low-volume centers. No benefit was observed in patients without coma (P =.05). Additionally, a shorter LOS was observed in patients with PAI and New Injury Severity Scores of 16 or higher (difference in adjusted mean LOS, 1.6 days [95% CI, -1.5 to 4.7 days]) and in all patients with multisystem blunt trauma admitted to higher-volume centers (difference in adjusted mean LOS, 3.3 days [95% CI, 0.91-5.70 days]).Conclusions: Our results indicate that a strong association exists between trauma center volume and outcomes, with significant improvements in mortality and LOS when volume exceeds 650 cases per year. These benefits are only evident in patients at high risk for adverse outcomes. [ABSTRACT FROM AUTHOR]

Published
2001
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