1. Role of histone acetylation in gastric cancer: implications of dietetic compounds and clinical perspectives.
- Author
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Calcagno DQ, Wisnieski F, Mota ERDS, Maia de Sousa SB, Costa da Silva JM, Leal MF, Gigek CO, Santos LC, Rasmussen LT, Assumpção PP, Burbano RR, and Smith MA
- Subjects
- Acetylation drug effects, Animals, Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use, Dietetics, Gene Expression Regulation, Neoplastic drug effects, Histone Deacetylase Inhibitors pharmacology, Histone Deacetylase Inhibitors therapeutic use, Humans, Protein Processing, Post-Translational, Stomach Neoplasms pathology, Stomach Neoplasms therapy, Disease Susceptibility, Histones metabolism, Stomach Neoplasms etiology, Stomach Neoplasms metabolism
- Abstract
Histone modifications regulate the structural status of chromatin and thereby influence the transcriptional status of genes. These processes are controlled by the recruitment of different enzymes to a specific genomic site. Furthermore, obtaining an understanding of these mechanisms could help delineate alternative treatment and preventive strategies for cancer. For example, in gastric cancer, cholecalciferol, curcumin, resveratrol, quercetin, garcinol and sodium butyrate are natural regulators of acetylation and deacetylation enzyme activity that exert chemopreventive and anticancer effects. Here, we review the recent findings on histone acetylation in gastric cancer and discuss the effects of nutrients and bioactive compounds on histone acetylation and their potential role in the prevention and treatment of this type of cancer.
- Published
- 2019
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