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295 results on '"Mahony D"'

7. Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin

Author

Tejera, Paula, Meyer, Nuala J, Chen, Feng, Feng, Rui, Zhao, Yang, OʼMahony, D Shane, Li, Lin, Sheu, Chau-Chyun, Zhai, Rihong, Wang, Zhaoxi, Su, Li, Bajwa, Ed, Ahasic, Amy M, Clardy, Peter F, Gong, Michelle N, Frank, Angela J, Lanken, Paul N, Thompson, B Taylor, Christie, Jason D, Wurfel, Mark M, OʼKeefe, Grant E, and Christiani, David C

Published
2012
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28. Irish Gerontological Society: Proceedings of annual scientific and general meeting held October 1993

Author

Healy, M., O’Moore, R., Keane, E. M., Coakley, D., Walsh, J. B., Tully, M., Swanwick, G., Coen, R., Bruce, I., O’Mahony, D., Radic, A., O’Kelly, F., O’Doherty, M., Lawlor, B. A., Lee, H., Conway, J., Keane, E., Ng, K., Murphy, S., Khaw, K-T., May, H., Compston, J. E., Taggart, H., Crawford, V., Twomey, C., Delaney, L., Crowley, M., Hyland, M., Hegarty, V., Donovan, M. C., Pye, M., Reardon, M., Coleman, P., Hyland, C. M., Scott, T., Keane, C. T., Farragher, B., O’Connor, A., Quinn, E., Mahony, D., Rowan, M., Buggy, F., Freyne, A., Wrigley, M., Passmore, A. P., Crawford, V. L. S., Beringer, T. R. O., Gilmore, D. H., Hussain, A., Grant, D., Montgomery, A., Hemeryck, L., McCormack, P. M. E., Sheehan, N., Guely, A., Leonard, L., Caulfield, D., Nic Cártaigh, M., Feely, J., Mulkerrin, E., Clark, B. A., Epstein, F. H., Keane, N., McCabe, E., Shepherd, M., O’Donnell, M. J., Cooper, R. A., Nurzaman, M., Brooks, R. W., Sinha, S. K., Kane, D., McKiernan, M., Crowe, J., Lennon, J., Sheehan, J., Rearden, M., Hyland, M., Tracey, F., Lawson, J. T., Stout, R. W., Williams, H., Naguib, M., O’Keefe, S., Lavan, J., Madigan, S. M., McNulty, H., Eaton-Evans, J., Strain, J. J., Stanwick, G., Horgan, F., Keating, D., Crowe, M., McNamara, A., Leahy, P., Healy, S., Moraes, D., Tyrell, J., Crawford, V. L. S., O’Keeffe, S., Glasgow, R., Tormey, W., Finucane, P., Nair, B. K., McCann, C., Coen, R. F., O’Boyle, C. A., Joyce, C. R. B., Hiltbrunner, B., Clarke, R., and Cooney, J.

Published
1994
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42. Treatment of Anterior Open Bite with the Bimler Functional Appliance: Report of Three Cases

Author

Ramirez-Yañez Go, Bimler B, and Mahony D

Subjects
Open bite, Orthodontics, medicine.medical_specialty, business.industry, Dentistry, Treatment results, medicine.disease, medicine.anatomical_structure, Tongue, Dental surgery, Medicine, Active treatment, Malocclusion, business, Mixed dentition, Restorative dentistry
Abstract

There is still controversy regarding the efficacy of functional appliances when treating malocclusion at an early age. Although a good outcome from treatment is important, the stability of the results over time becomes a major concern. This paper presents the results of three open bite cases treated with the Bimler type-A appliance in the mixed dentition. The open bite cases presented here demonstrate stability of the treatment results for more than 14 years without active retention after the active treatment period. A comparison between these cases and those performed with an elastic functional appliance, and the action of that appliance on tongue posture, are discussed. The cases presented in this paper support treating malocclusions at an early age with functional appliances. The features of the appliance chosen to treat an open bite early can be a key factor for the results and stability.

Published
2014
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43. Silica Vesicle Nanovaccine Formulations Stimulate Long-Term Immune Responses to the Bovine Viral Diarrhoea Virus E2 Protein

Author

Mody, K. T., Mahony, D., Cavallaro, A. S., Zhang, J., Zhang, B., Mahony, T. J., Yu, C. Z., Mitter, N., Mody, K. T., Mahony, D., Cavallaro, A. S., Zhang, J., Zhang, B., Mahony, T. J., Yu, C. Z., and Mitter, N.

Abstract

Bovine Viral Diarrhoea Virus (BVDV) is one of the most serious pathogen, which causes tremendous economic loss to the cattle industry worldwide, meriting the development of improved subunit vaccines. Structural glycoprotein E2 is reported to be a major immunogenic determinant of BVDV virion. We have developed a novel hollow silica vesicles (SV) based platform to administer BVDV-1 Escherichia coli-expressed optimised E2 (oE2) antigen as a nanovaccine formulation. The SV-140 vesicles (diameter 50 nm, wall thickness 6 nm, perforated by pores of entrance size 16 nm and total pore volume of 0.934 cm(3)g(-1)) have proven to be ideal candidates to load oE2 antigen and generate immune response. The current study for the first time demonstrates the ability of freeze-dried (FD) as well as non-FD oE2/SV140 nanovaccine formulation to induce long-term balanced antibody and cell mediated memory responses for at least 6 months with a shortened dosing regimen of two doses in small animal model. The in vivo ability of oE2 (100 mu g)/SV-140 (500 mu g) and FD oE2 (100 mu g)/SV-140 (500 mu g) to induce long-term immunity was compared to immunisation with oE2 (100 mu g) together with the conventional adjuvant Quil-A from the Quillaja saponira (10 mu g) in mice. The oE2/SV-140 as well as the FD oE2/SV-140 nanovaccine generated oE2-specific antibody and cell mediated responses for up to six months post the final second immunisation. Significantly, the cell-mediated responses were consistently high in mice immunised with oE2/SV-140 (1,500 SFU/million cells) at the six-month time point. Histopathology studies showed no morphological changes at the site of injection or in the different organs harvested from the mice immunised with 500 mu g SV-140 nanovaccine compared to the unimmunised control. The platform has the potential for developing single dose vaccines without the requirement of cold chain storage for veterinary and human applications.

Published
2015

44. In vivo delivery of bovine viral diahorrea virus, E2 protein using hollow mesoporous silica nanoparticles

Author

Mahony, D., Cavallaro, A. S., Mody, K. T., Xiong, L., Mahony, T. J., Qiao, S. Z., Mitter, N., Mahony, D., Cavallaro, A. S., Mody, K. T., Xiong, L., Mahony, T. J., Qiao, S. Z., and Mitter, N.

Abstract

Our work focuses on the application of mesoporous silica nanoparticles as a combined delivery vehicle and adjuvant for vaccine applications. Here we present results using the viral protein, E2, from bovine viral diarrhoea virus (BVDV). BVDV infection occurs in the target species of cattle and sheep herds worldwide and is therefore of economic importance. E2 is a major immunogenic determinant of BVDV and is an ideal candidate for the development of a subunit based nanovaccine using mesoporous silica nanoparticles. Hollow type mesoporous silica nanoparticles with surface amino functionalisation (termed HMSA) were characterised and assessed for adsorption and desorption of E2. A codon-optimised version of the E2 protein (termed Opti-E2) was produced in Escherichia coli. HMSA (120 nm) had an adsorption capacity of 80 [small mu ]g Opti-E2 per mg HMSA and once bound E2 did not dissociate from the HMSA. Immunisation studies in mice with a 20 [small mu ]g dose of E2 adsorbed to 250 [small mu ]g HMSA was compared to immunisation with Opti-E2 (50 [small mu ]g) together with the traditional adjuvant Quillaja saponaria Molina tree saponins (QuilA, 10 [small mu ]g). The humoral responses with the Opti-E2/HMSA nanovaccine although slightly lower than those obtained for the Opti-E2 + QuilA group demonstrated that HMSA particles are an effective adjuvant that stimulated E2-specific antibody responses. Importantly the cell-mediated immune responses were consistently high in all mice immunised with Opti-E2/HMSA nanovaccine formulation. Therefore we have shown the Opti-E2/HMSA nanoformulation acts as an excellent adjuvant that gives both T-helper 1 and T-helper 2 mediated responses in a small animal model. This study has provided proof-of-concept towards the development of an E2 subunit nanoparticle based vaccine.

Published
2014

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