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Saeed Akhlaghi,1 Maryam Sahebari,2 Mahmoud Mahmoodi,1 Mehdi Yaseri,1 Mohammad Ali Mansournia,1 Houshang Rafatpanah,3 Hojjat Zeraati1 1Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; 2Rheumatic Diseases Research Center (RDRC), Mashhad University of Medical Sciences, Mashhad, Iran; 3Inflammation and Inflammatory Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Purpose: One of the most important long-term side effects of therapy for rheumatoid arthritis (RA) is the elevation of liver function tests, with earlier studies reporting an elevation of more than 1× the upper limit of normal (>1 × ULN). The current study expands the literature by comparing the trends of transaminase changes caused by conventional and biologic disease-modifying antirheumatic drugs (DMARDs).Patients and methods: The drug categories examined were methotrexate (MTX) and all other nonbiologic DMARDs. Where RA patients exhibited inadequate response to conventional DMARDs (cDMARDs), we added biologic DMARDs (bDMARDs) to the treatment. We compared the trend of changes in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the patients receiving MTX with the trend observed in the patients whose treatment encompassed both bDMARDs and MTX. The comparison was conducted using random intercept models, which are a type of linear mixed effects model.Results: This work involved 512 RA patients (MTX: 450, MTX + infliximab [INF]: 26, MTX + etanercept [ETA]: 36), whose ALT and/or AST levels were measured in 1,786 visits (MTX: 1,543, MTX + INF: 107, MTX + ETA: 136). ALT and/or AST elevations greater than 1 × ULN were observed in 344 (19.3%) visits (MTX: 295 [19.1%], MTX + INF/ETA: 49 [20.2%]). In this study, the trends of ALT and AST changes increased when receiving MTX, while the INF/ETA addition decreased these trends. The random intercept models indicated that changes in the mean ALT levels were significantly different over the time for MTX and MTX + INF/ETA groups (β [SE] =-0.190 [0.093], P= 0.040) but changes in the mean AST levels were nonsignificantly different over the time for such groups (β [SE] =-0.099 [0.064], P=0.120).Conclusion: Despite a higher incidence of elevated transaminases during the use of MTX + INF/ETA, the combination of INF/ETA with MTX reduced transaminase levels and returned ALT levels to normal concentrations. Keywords: longitudinal, ALT, AST, DMARDs, biologic DMARDs, MTX

Background: Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood, characterized by excess lymphoblasts, and immature white blood cells that are continuously multiplying and overproducing in the bone marrow. The aim of this investigation was to measure the sensitivity of lymphocytes against gamma irradiation in patients with acute lymphoblastic leukemia, and also find out the effect of such irradiations in causing chromosomal abnormalities.Methods: In this investigation performed between April 2010 and July 2011, at the Department of Genetics, Cancer Institute of Iran, we studied the effects of gamma irradiation on the lymphocytes of 20 children with acute lymphoblastic leukemia. The lymphocytes of 30 healthy donors were used to establish as a normal response to gamma irradiation and seven age-matched ataxia telangiectasia patients were recruited as positive control. The chromosomal radiosensitivity was assessed with the G2- and the G0-assay. We compared the mean number of chromosomal abnormalities such as chromosome and chromatid breakages, chromosome and chromatid gaps, and chromatid exchanges in one-hundred metaphases of patients and control groups.Results: The frequency of chromosomal aberrations was statistically higher among patients with acute lymphoblastic leukemia than the normal controls (P

"n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: An increased risk for invasive infections with encapsulated bacteria such as Streptococcus pneumoniae has been described in patients with chronic kidney disease (CKD) or in those on dialysis. The aim of this study was to evaluate the antibody response to pneumococcal capsular polysaccharide vaccine in CKD patients. "n"nMethods : Sixty-six patients with CKD and 40 healthy individuals were vaccinated with pneumococcal polysaccharide vaccine. The serum antibody response (IgG and IgG2) to the Pneumovax antigens was determined by enzyme-linked immunosorbent assay (ELISA) prior to and four weeks after vaccination."n"nResults : Out of 66 vaccinated patients with CKD, 14 were found to be hyporesponsive to the vaccine (Group 1). Patients with normal specific antibody response were regarded as respondents and were assigned to Group 2 (n=52). The mean post-vaccination IgG titer to the pneumococcal antigens in Group 1 was significantly lower than those in Group 2 (P=0.012 for IgG and P=0.02 for IgG2). The increased anti-pneumococcal IgG titer was significantly lower in patients in Group 1 versus Group 2 (P=0.001) or the healthy control group (P=0.005). During the follow-up period of patients, patients in Group 1 developed higher episodes of pneumococcal infections than those in Group 2 (P=0.007). "n"nConclusion: A substantial proportion of patients with chronic kidney disease fail to mount an adequate antibody response to pneumococcal antigens and remain at significant risk for such infections. These patients should be offered other prophylactic measures to protect them against invasive pneumococcal diseases."n"nKeywords: Antibody response, chronic kidney disease, polysaccharide vaccine.

Background and Objective: An increased risk of invasive infections with encapsulated bacteria such as Streptococcus pneumoniae has been described among splenectomized patients. Pneumococcal vaccination has been recommended in these patients. In this study, the serum antibody response to pneumococcal polysaccharide antigens in splenectomized patients with idiopathic thrombocytopenic purpura (ITP) or trauma who immunized with Pneumovax 23 was evaluated. Materials and Methods: This case - control study was performed on two groups of patients including fifteen cases of trauma patients (11 male, 4 female) and twenty patients with ITP (10 male, 10 female) along with 40 healthy volunteers as controls who were immunized with Pneumovax 23 to prevent pneumococcal infections. All patients received the pneumococcal vaccine before splenectomy. The serum antibody response (IgG and IgG2) to pneumococcal antigens was determined by enzyme-linked immunosorbent assay (ELISA) technique prior to vaccination and 4 weeks post-vaccination. Analyzing of data was performed using student t-test and linear regression test. Results: The mean of post-vaccination IgG or IgG2 titer to the pneumococcal antigens in ITP patient group was significantly lower than those in controls or in trauma group (P

"n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Based on the reports, high frequency of special alleles of HLA class II genes might be associated with susceptibility to or protective from a particular cancer. These alleles might vary depending on the geographical region. Here we investigate the association between alleles of HLA class II genes and breast cancer in Iranian women."n"nMethods: 100 patients with pathologically proved breast cancer who referred to Cancer Institute, Tehran University of Medical Sciences in Tehran, Iran, were divided to two groups based on ages (40 years old and less/ or more than 40 years old) and were randomly selected and compared with a group of 80 healthy blood donor subjects. HLA class II alleles were determined by amplification of DNA with polymerase chain reaction (PCR) method followed by HLA-typing using sequence-specific primer (SSP) for each allele."n"nResults: The most frequent alleles in the DR and DQ regions in group 1 (40 years old and less) in comparison with control group were HLA-DQA1*0301 (p=0.002) and HLA-DQB1*0302 (p>0.05). In contrast HLA-DQA1*0505 (p=0.004) had significantly lower frequency in this group compared with control group. Patients of group two (more than 40 years old) had a higher frequencies of HLA-DQA1*0301 (p=0.001) and HLA-DRB1*1303 (p=0.02) and a lower frequency of HLA-DQA1*0101 (p=0.002) compared to healthy control."n"nConclusion: These findings provide information of a positive and negative association between certain alleles of HLA class II and breast cancer in our population and also might support that the pattern of inheritance in the early and late onset of breast cancer differ substantially.

"n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Human respiratory syncytial virus (HRSV) is the most important viral agent of acute lower respiratory tract disease in infants and young children worldwide. This virus is responsible for 50% brochiolitis and 25% pneumonia in infants. There are limited data of molecular epidemiology of HRSV from developing countries. This is the report on the molecular epidemiology of human respiratory syncytial virus in Iran."n"nMethods: In this study, RT-PCR for second hypervariable region of the HRSV G glycoprotein was performed on 72 throat swabs collected from children less than 5 years of age with acute respiratory symptoms in 1386."n"nResults: Of the 72 throat swabs collected from children with acute respiratory symptoms, 14 (19.44%) were positive for HRSV. Phylogenetic analysis revealed that all HRSV-positive samples clustered in three genotypes of subgroup A: 12 strains (85/71%) in genotype GA2, 1 strain (7/1%) in genotype GA1, and 1 strain (7/1%) in genotype GA5. In this study we couldn't identify any genotype of subgroup B."n"nConclusion: Our results revealed that multiple genotypes of subgroup A were co-circulated during 1386 in children less than 5 years of age in Iran. Also this study revealed that genotype GA2 was predominant genotype in isolates were obtained from several cities (Tehran, Isfahan, Karaj, Qazvin, Bandar Abbas, Shahreza), so we speculate that this genotype may be predominant during 1386 in Iran. This study supported that RT-PCR for second variable region of G protein is an effective method for further studies of HRSV genotype designation in Iran.

"n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: 4-Aryl-4H-chromenes are novel anticancer agents which induce apoptosis in cancer cells. These compounds were found to induce apoptosis by targeting the tubulin/microtubule system in cell proliferation process. The aim of this study was to report cyototoxic and apoptosis inducing activities of a new series of synthesized 4-aryl-4H-chromenes compounds."n"n Methods: The in vitro cytotoxic activity of the synthesized 4-aryl-4H-chromenes was investigated against a paned of human cancer cell lines including MCF-7 (breast carcinoma), A549 (lung carcinoma), HEPG-2 (liver carcinoma), SW-480 (colon adenocarcinoma), U87-MG (glioblastoma), 1321N1 (astrocytoma), and DAOY (medulloblastoma). The percentage of growth inhibitory activity was evaluated using MTT colorimetric assay versus controls not treated with test derivatives. The data for etoposide, a well known anticancer drug, was included for comparison. For each compound, the 50% inhibitory concentration (IC50) were determined. Apoptosis inducing activity were assessed by DAPI staining."n"n Results: Preliminary screening showed that those chromenes analogs bearing phenyl-isoxazole-3-yl substitution or the derivatives containing methoxyphenyl in chromene ring exhibited cytotoxic and apoptotic inducing activity comparable with or even superior than the reference drug, etoposide. The compounds without this type of substitution have lower activity. "n"nConclusions: Replacement of 3, 4, 5-trimethoxyphenyl group with thiazol ring in the synthesized derivatives reduced the cytotoxic activity. However, the derivatives with phenyl-isoxazole analogue showed potent cytotoxic and apoptotic inducing activity.

We have analyzed paraffin sections from 55 patients with histologically confirmed Hodgkin’s disease (HD) for the presence of Epstein-Barr virus (EBV) markers using in situ hybridization to detect the EBV-encoded RNAs (EBERs) and immunohistochemistry to identify latent membrane protein-1 (LMP1) expression. Tissue specimens from 55 cases of Hodgkin’s disease included 22-mixed cellularity (MC), 27 nodular sclerosis (NC), one lymphocyte depleted (LD) and 5 lymphocyte predominance (LP). All of the confirmed EBV associated cases were examined and subtyped of the presence of Epstein-Barr virus (EBV) DNA by polymerase chain reaction. In situ hybridization revealed exclusive localization of virus in the tumor cells and FBV markers were present in 30 HD cases (55%) and were mainly confined to the mixed cellularity (MC) and nodular sclerosis (NC) subtypes. 1-MH immunohistochemistry has similar results as in situ hybridization. EBV positivity with regards of HD subtypes were 64% (14/22) mixed cellularity (MC), 44% (12/27) nodular sclerosis (NS), 0% (0/1) lymphocyte depleted (LD) and 80% (4/5) lymphocyte predominance (LP). Epstein-Barr virus-specific DNA sequences were detected by PCR in DNA extracts from paraffin-embedded tissues of all LMP1 positive cases. Twenty-eight cases were type 1 EBV and 2 cases type 2 EBV. There was difference between EBV-positive and EBV-negative HD patients with regard to age. Analysis of age group 1-14 years, 15-49 years and over 49 years, revealed 73% (16/22), 35% (10/29), 100% (4/4) EBV positivity, respectively. These findings compared to the EBV association pattern with HD in developed and developing countries suggest an overall intermediate pattern of EBV association with HD and high incidence of EBV children and elderly HD cases.

Objective(s): To assess the in influence of maternal request on the elective cesarean section rate and related factors in maternity hospitals in Tehran. Material & Metods: This was a cross-sectional study using data from 824 pregnant women via a two• step random sampling. A standardized form was completed for each mother, collecting past and present obstetric history and demographic characteristics. Results: 66.5% of mothers delivered by cesarean section and 33.5% vaginally. 72% of cesareans were elective and of these 22% were performed because of maternal request and 71 % of mothers who requested cesarean had no explanations for their request. Also 65% of doctors suggested cesarean for their patients without any true medical indications. The majority of elective cesarean section on maternal request were performed in private hospitals (86% in private VS. 14% in state hospitals, P

Myocardial infarction sequel of coronary artery diseases, can be sometimes asymptomatic, called silent myocardial infarction. Some risk factors predispose the patients to this condition. In this study, we intend to determine the predisposing factors in such patients."nMethods and Materials: We included those patients with electrocardiogram changes, consistent with myocardial infarction, who had not any symptoms of ischemia or a previous history of coronary artery disease, consulted for preoperative work up of eye surgery during the year 2000."nResults: We analyzed 100 patients with the diagnosis of silent myocardial infarction. (59 males and 41 females). Among our patients. 99 percent were above age 50 years of age. Their mean age at the time of study was 69.7 years. 78 percent of patients were illiterate. In 41 of them body mass index was above the normal limits (overweight and obese). Their past medical history revealed that 46 patients had hypertension, 38 patients had hyper-lipidemia. and 26 patients had diabetes mellitus. Also, a positive family history of coronary artery disease was seen in 52 percent of the patients. The rate of cigarette smokers and opium addicts, among our patients, was 33 and 13 percents. respectively. Analysis of electrocardiogram changes, showed that 43 patients had inferior myocardial infarction, 24 had antero-septal. and 17 of them suffered from anterior myocardial infarction."nConclusion: Almost all of our patients with silent myocardial infarction were in old age group. Diabetes mellitus, hypertension, overweight, hyper-lipidemia, and a positive family history of coronary artery disease were the most important predisposing factors, found in such patients, thus taking into account these predisposing factors and control of them would dramatically reduce the prevalence of morbidity and mortality of silent myocardial infarction.

Objective(s): To assess the cesarean rate and related factors in maternity hospitals in Tehran. Material & Methods: This was a cross-sectional study using data from 824 pregnant women via a two• step random sampling. A standardised form was completed for each mother, collecting past and present obstetric history and demographic characteristics. Results: 66.5% of mothers delivered by cesarean section & 33.5% vaginaly. 72% of cesareans were elective. Of these 22% were done because of maternal request and 71 % of mothers who requested cesarean had no logic reason for their request. Also 65% of doctors suggested cesaran for their patients without any true medical indications. The majority of cesarean sections were performed in private hospitals (84% in private vs. 47% in public hospitals (P

Population growth has been one of the main anxieties of different countries planners so far. Background and purpose growth of population has always had various impacts on society in economical, social, health and even political fields and its cure is controlling population growth. In order to study the efficient factors upon unwanted children, 1527 married women in Tehran have been randomly selected and data from questionnaire was selected. In this study, effective factors such as couple's education level, couple's occupation, number of children, age of marriage, age of last pregnancy, having stillbirth, breast feeding period in last born and effect of sex of infant in family planning upon unwanted children have been studied. Results show that some factors like husband's age, number of children, age of first marriage, age of last pregnancy, husband occupation, having stillbirth, breast feeding period and effect of infant's sex in family planning increase the chance of unwanted children and some criteria like women age, woman's education, fist pregnancy age, woman occupation, decrease the chance of unwanted children. According to logistic regression model, women age is one of the most important effective factors and one year increment in woman's age increase the chance of unwanted child 0.89 more times. Other factors is the number of children that in return for increasing one child to family, the chance of un wanting become 116.8 more times. It seems families don't have enough knowledge about family planning measures and their usage. Breast feeding period in wives who have fed their last children for more than six months, is another important factor which increases the chance of unwanted child to 1.02 more times than woman who have fed their last children for less than six months.

Lipoprotein (a) [Lp (a) is formed by assembly of LDL-particles and the carbohydrate rich protein, apolipoprotein (a) [apo (a)]. Elevated plasma Lp (a) levels are an independent predictor of the development of premature coronary artery disease (CAD), but is not clear whether the apo (a) isoform plays on additional and independent role or not. To investigate the possible effect of apo (a) isoform on premature CAD (in patients < 55 years of age), we have analyzed apo (a) isoforms, Lp (a) level and their relation with many recognized CAD risk factors, in 60 male patients with angiographically defined CAD and in 60 male control with no angiographic evidence of CAD. The results show elevated Lp (a) concentration (29.4±16.1, vs. 16.5±9.9 P

This descriptive study is carried out to determine the effectiveness of family planning programmes in Iran for years 1991-96. The study revealed the following outlines: Contraceptives prevalence rates increased from 42% to 67% during years 1991-96. Zaro couples years of protection increased for norplant, injectable contraceptive, IUD, vasectomy and tubectomy, but for candom it is decreased in year 1996 (Comparing to earlier years of the study). A decrease in use failure rate of contraceptives was observed during the period of the study.

This is a report of the first serological survey of influenza C virus in Iran, performed during a one year period (March 1997-May 1998). This study was accomplished in the National Influenza Center-Division of Virology in Tehran University of Medical Scinces. 1080 samples of serum (689 samples from Tehran and 391 samples from other provinces) were assayed for the presence of antibodies against influenza C virus (C/Paris/1/67) by haemagglutination inhibition (HI) test. 43.7% of people tested in Tehran and 40.7% of people tested from other provinces had protective antibodies against influenza C virus. Distribution of seropositives in various age groups had a somewhat similar pattern as what has been reported from other countries. The results of this study indicates that the lowest level of protective antibody titer is found at childhood and the level increases with age. The protective antibody titer level off for 20-30 years old age group and decreases in older age groups. These results indicates a primary contact in childhood, reinfection in adulthood. The influenza C virus is simultaneously circulating in Iran with other types of influenza viruses (types A and B).

Objective (s): The prevalence of obesity has increased in both developed and developing countries. Childhood and adolescent obesity can lead to serious medical complications such as hypertension, diabetes, cardiovascular disease and cancer in later years of life. The aim of this study was to assess the relationship between obesity and some nutritional behavior. Methods: This was a case-control study. Through multi-stage random sampling, 84 obese girls were selected as cases and 253 non-obese girls from the same age and grade as control. Obesity was defined as having a BMI equal to or greater than 95lh centile. Weights and heights were measured to an accuracy of O. l kg, using digital scales and non-stretchable tape (Seca) with minimum clothing. We used a questionnaire 10 collect data on nutritional behavior. Results: There was a statistically significant greater frequency of eating meals and snacks during the day in controls (P=0/0001, P=0/003). Weekly frequency of eating breakfast was smaller in cases but the difference was not significant. There was no difference between the two groups in variables such as eating out, food preference, speed of eating and doing something else while eating. Conclusion: It seems that there is a relationship between obesity among school students and their nutritional behaviors.

In this paper, the fusion cross sections of 6He + 197Au and 8He + 197Au systems have been investigated at center-of-mass energies from below to above the Coulomb barrier, 14.5 to 60.0 and 15.0 to 29.0 MeV, respectively. The required nucleus-nucleus potential has been calculated by using the Monte Carlo method, applying four different phenomenological density distributions. The results obtained from both systems reveal that considering the suitable halo structure for distribution of the nuclear matter increases the height of fusion barrier, giving a better agreement with the experimental data. In addition, by using the generalized function of the two-parameter Fermi distribution for the nuclear density of the halo nucleons of 6He and 8He nuclei, a better agreement with experimental data was achieved. Using the same potential with the above-mentioned density distributions, we also studied the elastic scattering cross sections for the 6He + 197Au system measured at Elab. = 29 MeV and Elab. = 40 MeV, with similar good results as for the fusion reaction. [ABSTRACT FROM AUTHOR]

The melt quenching technique was utilized to prepare a novel mixed alkali bioglass composition, denoted as 30B2O3–20SiO2–xNa2O–(20–x)Li2O–20CaO–10ZnO, where x = 0,5,10,and 20 and samples codes were BSCZ0, BSCZ5, BSCZ10, BSCZ15 and BSCZ20. The sample code of present samples indicate as BSCZ0 to The glass properties were evaluated using density, FTIR, and radiation shielding capacity, and the simulated body fluid (SBF) solution was prepared according to Kokubo's method. The bio-activeness of the prepared glasses was confirmed by XRD and FTIR spectra, which exhibited crystalline peaks at various reflections due to the formation of calcite and hydroxyapatite layers on the glass surface. The FTIR spectra revealed the formation of hydroxyapatite layers after fourteen days of SBF treatment, as evidenced by the strong intensive peaks around 1020 cm−1. The experimental density values vary between 3.1926 g/cc to 3.1605 g/cc. The glass density decreased with increasing Na2O content due to the decreasing number density correlated to the alkali content. To predict the glass density, an artificial intelligence density model was applied to the present glasses, which utilized 10,000 oxide glass samples. Among the different regression models tested, random forest regression produced the best R2 value (0.917), followed by artificial neural network and polynomial regression. In the case of RFR the predicted density values varies from 3.1626 g/cc to 3.1305 g/cc which were closer values to the experimental density values. The radiation shielding properties of present glasses studied by Phy-X/PSD program and simulated by FLUKA code in the photon energy range of 0.015–15 MeV. Results show that there is a good agreement between the obtained results. BSCZ0, which was free of Na2O, exhibited the highest values of mass (µm) and linear (µ) attenuation coefficients compared to all other glasses, and the effective atomic number (Zeff) achieved the same trend as µm and µ. Sample BSCZ0 also exhibited the lowest values of half value layer (HVL) parameter at all incident photon energies. [ABSTRACT FROM AUTHOR]