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17. Variation in paediatric hospital antibiotic guidelines in Europe

Author

Spyridis, N, Syridou, G, Goossens, H, Versporten, A, Kopsidas, J, Kourlaba, G, Bielicki, J, Drapier, N, Zaoutis, T, Tsolia, M, Sharland, M, Vergison, A, Léon, V, Delestrait, M, Huza, C, Lepage, P, Mahieu, L, Boy, T, Jansens, H, Van der Linden, D, Briquet, C, Allegaert, K, Smits, A, Gabriels, P, Vuye, A, Lutsar, I, Tamm, E, Larionova, A, Laan, D, Orbach, M, Lorrot, M, Angoulvant, F, Prot-Labarthe, S, Dubos, F, Lagree, M, Hufnagel, M, Schuster, K, Henneke, P, Roilides, E, Iosifidis, E, Corovessi, V, Michos, A, Galanakis, E, Gkentzi, D, Giacquinto, C, Longo, G, Dona, D, Mion, T, DʼArgenio, P, Degli, ML Ciofi, De Luca, M, Ciliento, G, Esposito, S, Danieli, E, Montinaro, V, Tenconi, R, Nicolini, G, Sviestina, C I Montagnani, Pavare, J, Rasnaca, K, Gardovska, D, Grope, I, Usonis, V, Gurksniene, V, Eidukaite, A, Biver, A, Brett, A, Esteves, I, Cambrea, SC, Craiu, M, Tomescu, E, Cizman, M, Babnik, J, Kenda, R, Vidmar, I, Nunez-Cuadros, E, Rojo, P, Lopez-Varela, E, Ureta, N, Mosqueda, R, Perez-Lopez, A, Orta, L, Santos, M, Navarro, M, Santiago, B, Hernandez-Sampelaya, T, Saavedra, J, Pineiro, R, Torel, P, Mate Cano, I, Baumann, P, Berger, C, Menson, E, Botgros, A, Doerholt, K, Drysdale, S, Makwana, N, McCorry, A, Garbash, EM, Chetcutiganado, C, McLeod, M, Caldwell, N, Nash, C, McCullagh, B, Sharpe, D, Tweddell, L, Liese, JG, Aston, J, Gallagher, A, Satodia, P, Howard-Smith, N, Korinteli, I, Tavchioska, G, Jensen, L, Trethon, A, Unuk, S, Childs, N, and Canlas, J

Published
2016
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29. The worldwide Antibiotic Resistance and Prescribing in European Children (ARPEC) point prevalence survey: developing hospital-quality indicators of antibiotic prescribing for children

Author

Versporten A1, Bielicki J2, Drapier N1, Sharland M2, Goossens H3, ARPEC project group. Calle GM, Garrahan JP, Clark J, Cooper C, Blyth CC, Francis JR, Alsalman J, Jansens H, Mahieu L, Van Rossom P, Vandewal W, Lepage P, Blumental S, Briquet C, Robbrecht D, Maton P, Gabriels P, Rubic Z, Kovacevic T, Nielsen JP, Petersen JR, Poorisrisak P, Jensen LH, Laan M, Tamm E, Matsinen M, Rummukainen ML, Gajdos V, Olivier R, Le Maréchal F, Martinot A, Dubos F, Lagrée M, Prot-Labarthe S, Lorrot M, Orbach D, Pagava K, Hufnagel M, Knuf M, Schlag SA, Liese J, Renner L, Enimil A, Awunyo M, Syridou G, Spyridis N, Critselis E, Kouni S, Mougkou K, Ladomenou F, Gkentzi D, Iosifidis E, Roilides E, Sahu S, Murki S, Malviya M, Kalavalapalli DB, Singh S, Singhal T, Garg G, Garg P, Kler N, Soltani J, Jafarpour Z, Pouladfar G, Nicolini G, Montagnani C, Galli L, Esposito S, Tenconi R, Lo Vecchio A, Dona' D, Giaquinto C, Borgia E, D'Argenio P, De Luca M, Centenari C, Raka L, Raka D, Omar A, Al-Mousa H, Mozgis D, Sviestina I, Burokiene S, Usonis V, Tavchioska G, Hargadon-Lowe A, Zarb P, Borg MA, González Lozano CA, Zárate Castañon P, Cancino ME, McCullagh B, McCorry A, Gormley C, Al Maskari Z, Al-Jardani A, Pluta M, Rodrigues F, Brett A, Esteves I, Marques L, Ali AlAjmi J, Claudia Cambrea S, Rashed AN, Mubarak Al Azmi AA, Chan SM, Isa MS, Najdenov P, Čižman M, Unuk S, Finlayson H, Dramowski A, Maté-Cano I, Soto B, Calvo C, Santiago B, Saavedra-Lozano J, Bustinza A, Escosa-García L, Ureta N, Lopez-Varela E, Rojo P, Tagarro A, Barrero PT, Rincon-Lopez EM, Abubakar I, Aston J, Heginbothom M, Satodia P, Garbash M, Johnson A, Sharpe D, Barton C, Menson E, Arenas-Lopez S, Luck S, Doerholt K, McMaster P, Caldwell NA, Lunn A, Drysdale SB, Howe R, Scorrer T, Gahleitner F, Gupta R, Nash C, Alexander J, Raman M, Bell E, Rajagopal V, Kohlhoff S, Cox E, Zaoutis T., Mahieu, Ludo, ARPEC Project Grp, ARPEC project group, Versporten, A1, Bielicki, J2, Drapier, N1, Sharland, M2, Goossens, H3, ARPEC project group., Calle GM, Garrahan, Jp, Clark, J, Cooper, C, Blyth, Cc, Francis, Jr, Alsalman, J, Jansens, H, Mahieu, L, Van Rossom, P, Vandewal, W, Lepage, P, Blumental, S, Briquet, C, Robbrecht, D, Maton, P, Gabriels, P, Rubic, Z, Kovacevic, T, Nielsen, Jp, Petersen, Jr, Poorisrisak, P, Jensen, Lh, Laan, M, Tamm, E, Matsinen, M, Rummukainen, Ml, Gajdos, V, Olivier, R, Le Maréchal, F, Martinot, A, Dubos, F, Lagrée, M, Prot-Labarthe, S, Lorrot, M, Orbach, D, Pagava, K, Hufnagel, M, Knuf, M, Schlag, Sa, Liese, J, Renner, L, Enimil, A, Awunyo, M, Syridou, G, Spyridis, N, Critselis, E, Kouni, S, Mougkou, K, Ladomenou, F, Gkentzi, D, Iosifidis, E, Roilides, E, Sahu, S, Murki, S, Malviya, M, Kalavalapalli, Db, Singh, S, Singhal, T, Garg, G, Garg, P, Kler, N, Soltani, J, Jafarpour, Z, Pouladfar, G, Nicolini, G, Montagnani, C, Galli, L, Esposito, S, Tenconi, R, Lo Vecchio, A, Dona', D, Giaquinto, C, Borgia, E, D'Argenio, P, De Luca, M, Centenari, C, Raka, L, Raka, D, Omar, A, Al-Mousa, H, Mozgis, D, Sviestina, I, Burokiene, S, Usonis, V, Tavchioska, G, Hargadon-Lowe, A, Zarb, P, Borg, Ma, González Lozano, Ca, Zárate Castañon, P, Cancino, Me, Mccullagh, B, Mccorry, A, Gormley, C, Al Maskari, Z, Al-Jardani, A, Pluta, M, Rodrigues, F, Brett, A, Esteves, I, Marques, L, Ali AlAjmi, J, Claudia Cambrea, S, Rashed, An, Mubarak Al Azmi, Aa, Chan, Sm, Isa, M, Najdenov, P, Čižman, M, Unuk, S, Finlayson, H, Dramowski, A, Maté-Cano, I, Soto, B, Calvo, C, Santiago, B, Saavedra-Lozano, J, Bustinza, A, Escosa-García, L, Ureta, N, Lopez-Varela, E, Rojo, P, Tagarro, A, Barrero, Pt, Rincon-Lopez, Em, Abubakar, I, Aston, J, Heginbothom, M, Satodia, P, Garbash, M, Johnson, A, Sharpe, D, Barton, C, Menson, E, Arenas-Lopez, S, Luck, S, Doerholt, K, Mcmaster, P, Caldwell, Na, Lunn, A, Drysdale, Sb, Howe, R, Scorrer, T, Gahleitner, F, Gupta, R, Nash, C, Alexander, J, Raman, M, Bell, E, Rajagopal, V, Kohlhoff, S, Cox, E, and Zaoutis, T.

Subjects
0301 basic medicine, Male, Pediatrics, Latin Americans, Cross-sectional study, Prevalence, Psychological intervention, Drug resistance, Global Health, infectious diseases, 0302 clinical medicine, Global health, Medicine, 030212 general & internal medicine, Child, antibiotics, children, Drugs -- Prescribing, Pharmacology. Therapy, Hospitals -- Europe, Drug Resistance, Microbial, Hospitals, Anti-Bacterial Agents, Europe, Child, Preschool, Anti-infective agents, Female, medicine.drug, Microbiology (medical), medicine.medical_specialty, Cefepime, 030106 microbiology, Drug Prescriptions, 03 medical and health sciences, Surgical prophylaxis, pharmacology, pharmacology (medical), Environmental health, Humans, Biology, Quality Indicators, Health Care, business.industry, Health status indicators -- Europe, Infant, Drug Utilization, Cross-Sectional Studies, Health Care Surveys, Human medicine, business
Abstract

Objectives: Previously, web-based tools for cross-sectional antimicrobial point prevalence surveys (PPSs) have been used in adults to develop indicators of quality improvement. We aimed to determine the feasibility of developing similar quality indicators of improved antimicrobial prescribing focusing specifically on hospitalized neonates and children worldwide. Methods: A standardized antimicrobial PPS method was employed. Included were all inpatient children and neonates receiving an antimicrobial at 8:00 am on the day of the PPS. Denominators included the total number of inpatients. A web-based application was used for data entry, validation and reporting. We analysed 2012 data from 226 hospitals (H) in 41 countries (C) from Europe (174H; 24C), Africa (6H; 4C), Asia (25H; 8C), Australia (6H), Latin America (11H; 3C) and North America (4H). Results: Of 17693 admissions, 6499 (36.7%) inpatients received at least one antimicrobial, but this varied considerably between wards and regions. Potential indicators included very high broad-spectrum antibiotic prescribing in children of mainly ceftriaxone (ranked first in Eastern Europe, 31.3%; Asia, 13.0%; Southern Europe, 9.8%), cefepime (ranked third in North America, 7.8%) and meropenem (ranked first in Latin America, 13.1%). The survey identified worryingly high use of critically important antibiotics for hospital-acquired infections in neonates (34.9%; range from 14.2% in Africa to 68.0% in Latin America) compared with children (28.3%; range from 14.5% in Africa to 48.9% in Latin America). Parenteral administration was very common among children in Asia (88%), Latin America (81%) and Europe (67%). Documentation of the reasons for antibiotic prescribing was lowest in Latin America (52%). Prolonged surgical prophylaxis rates ranged from 78% (Europe) to 84% (Latin America). Conclusions: Simple web-based PPS tools provide a feasible method to identify areas for improvement of antibiotic use, to set benchmarks and to monitor future interventions in hospitalized neonates and children. To our knowledge, this study has derived the first global quality indicators for antibiotic use in hospitalized neonates and children., peer-reviewed

Published
2018

35. Variation in paediatric hospital antibiotic guidelines in Europe

Author

Spyridis, N., Syridou, G., Goossens, H., Versporten, A., Kopsidas, J., Kourlaba, G., Bielicki, J., Drapier, N., Zaoutis, T., Tsolia, M., Sharland, M., Vergison, A., Leon, V., Delestrait, M., Huza, C., Lepage, P., Mahieu, L., Boy, T., Jansens, H., Van Der Linden, D., Briquet, C., Allegaert, K., Smits, A., Gabriels, P., Vuye, A., Lutsar, I., Tamm, E., Larionova, A., Laan, D., Orbach, M., Lorrot, M., Angoulvant, F., Prot-Labarthe, S., Dubos, F., Lagree, M., Hufnagel, M., Schuster, K., Henneke, P., Roilides, E., Iosifidis, E., Corovessi, V., Michos, A., Galanakis, E., Gkentzi, D., Giacquinto, C., Longo, G., Dona', D., Mion, T., D'Argenio, P., Degli, M. L. C., De Luca, M., Ciliento, G., Esposito, S., Danieli, E., Montinaro, V., Tenconi, R., Nicolini, G., Sviestina, C. I. M., Pavare, J., Rasnaca, K., Gardovska, D., Usonis, V., Grope, I., Gurksniene, V., Eidukaite, A., Biver, A., Brett, A., Esteves, I., Cambrea, S. C., Craiu, M., Tomescu, E., Cizman, M., Babnik, J., Kenda, R., Vidmar, I., Nunez-Cuadros, E., Rojo, P., Lopez-Varela, E., Ureta, N., Perez-Lopez, A., Mosqueda, R., Orta, L., Santos, M., Navarro, M., Santiago, B., Hernandez-Sampelaya, T., Saavedra, J., Pineiro, R., Torel, P., Cano, I. M., Baumann, P., Berger, C., Menson, E., Botgros, A., Doerholt, K., Drysdale, S., Makwana, N., Mccorry, A., Garbash, E. M., Chetcutiganado, C., Mcleod, M., Caldwell, N., Nash, C., Mccullagh, B., Sharpe, D., Tweddell, L., Liese, J. G., Aston, J., Gallagher, A., Satodia, P., Howard-Smith, N., Korinteli, I., Tavchioska, G., Jensen, L., Trethon, A., Unuk, S., Childs, N., Canlas, J., Mahieu, Ludo, and ARPEC Project Grp

Subjects
Pediatrics, practice guidelines as topic, Antibiotics, cross-sectional studies, respiratory tract infections, sepsis, 0302 clinical medicine, newborn, Medicine, 030212 general & internal medicine, Practice Patterns, Physicians', humans, European paediatric hospitals, antibiotic guidelines, childhood infection, anti-bacterial agents, bacterial infections, child, preschool, drug administration schedule, drug prescriptions, Europe, hospitals, pediatric, infant, practice patterns, physicians', urinary tract infections, pediatrics, perinatology and child health, Antistaphylococcal penicillins, Respiratory tract infections, Neonatal sepsis, Hospitals, Pediatric, Child, Preschool, medicine.drug, medicine.medical_specialty, medicine.drug_class, Sepsis, 03 medical and health sciences, 030225 pediatrics, Internal medicine, business.industry, Infant, Newborn, Guideline, Amoxicillin, medicine.disease, Penicillin, Pediatrics, Perinatology and Child Health, Human medicine, business
Abstract

ObjectiveTo assess the availability and source of guidelines for common infections in European paediatric hospitals and determine their content and characteristics.DesignParticipating hospitals completed an online questionnaire on the availability and characteristics of antibiotic prescribing guidelines and on empirical antibiotic treatment including duration of therapy for 5 common infection syndromes: respiratory tract, urinary tract, skin and soft tissue, osteoarticular and sepsis in neonates and children.Results84 hospitals from 19 European countries participated in the survey of which 74 confirmed the existence of guidelines. Complete guidelines (existing guidelines for all requested infection syndromes) were reported by 20% of hospitals and the majority (71%) used a range of different sources. Guidelines most commonly available were those for urinary tract infection (UTI) (74%), neonatal sepsis (71%) and sepsis in children (65%). Penicillin and amoxicillin were the antibiotics most commonly recommended for respiratory tract infections (RTIs) (up to 76%), cephalosporin for UTI (up to 50%) and for skin and soft tissue infection (SSTI) and bone infection (20% and 30%, respectively). Antistaphylococcal penicillins were recommended for SSTIs and bone infections in 43% and 36%, respectively. Recommendations for neonatal sepsis included 20 different antibiotic combinations. Duration of therapy guidelines was mostly available for RTI and UTI (82%). A third of hospitals with guidelines for sepsis provided recommendations for length of therapy.ConclusionsComprehensive antibiotic guideline recommendations are generally lacking from European paediatric hospitals. We documented multiple antibiotics and combinations for most infections. Considerable improvement in the quality of guidelines and their evidence base is required, linking empirical therapy to resistance rates.

Published
2015
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39. Caractéristiques IRM des neuromyélites optiques associées aux anticorps anti-MOG

Author

Denève, M., primary, Biotti, D., additional, Dumas, H., additional, Patsoura, S., additional, Ferrier, M., additional, Meluchova, Z., additional, Mahieu, L., additional, Heran, F., additional, Vignal, C., additional, Deschamps, R., additional, Gout, O., additional, Menjot de Champfleur, N., additional, Ayrignac, X., additional, Dallière, C.C., additional, Labauge, P., additional, Cognard, C., additional, Brassat, D., additional, and Bonneville, F., additional

Published
2018
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40. SYSTÈME ET QUESTIONS

Author

Gilson, E., Mahieu, L., Landry, B., Descamps, Bon, Baur, L., Lehmen, P., Joyce, P., Stufler, P. J., Vincent, F., Picard, P. G., and Descoqs, Pedro

Published
1924

44. The worldwide antibiotic resistance and prescribing in european children (ARPEC) point prevalence survey: Developing hospital-quality indicators of antibiotic prescribing for children

Author

Versporten, A. Bielicki, J. Drapier, N. Sharland, M. Goossens, H. Calle, G.M. Clark, J. Cooper, C. Blyth, C.C. Francis, J.R. Alsalman, J. Jansens, H. Mahieu, L. Van Rossom, P. Vandewal, W. Lepage, P. Blumental, S. Briquet, C. Robbrecht, D. Maton, P. Gabriels, P. Rubic, Z. Kovacevic, T. Nielsen, J.P. Petersen, J.R. Poorisrisak, P. Jensen, L.H. Laan, M. Tamm, E. Matsinen, M. Rummukainen, M.-L. Gajdos, V. Olivier, R. Le Maréchal, F. Martinot, A. Prot-Labarthe, S. Lorrot, M. Orbach, D. Pagava, K. Hufnagel, M. Knuf, M. Schlag, S.A.A. Liese, J. Renner, L. Enimil, A. Awunyo, M. Syridou, G. Spyridis, N. Critselis, E. Kouni, S. Mougkou, K. Ladomenou, F. Gkentzi, D. Iosifidis, E. Roilides, E. Sahu, S. Murki, S. Malviya, M. Kalavalapalli, D.B. Singh, S. Singhal, T. Garg, G. Garg, P. Kler, N. Soltani, J. Jafarpour, Z. Pouladfar, G. Nicolini, G. Montagnani, C. Galli, L. Esposito, S. Vecchio, A.L. Dona', D. Giaquinto, C. Borgia, E. D'Argenio, P. De Luca, M. Centenari, C. Raka, L. Omar, A. Al-Mousa, H. Mozgis, D. Sviestina, I. Burokiene, S. Usonis, V. Tavchioska, G. Hargadon-Lowe, A. Zarb, P. Borg, M.A. González Lozano, C.A. Castañon, P.Z. Cancino, M.E. McCullagh, B. McCorry, A. Gormley, C. Al Maskari, Z. Al-Jardani, A. Pluta, M. Rodrigues, F. Brett, A. Esteves, I. Marques, L. AlAjmi, J.A. Cambrea, S.C. Rashed, A.N. Al Azmi, A.A.M. Chan, S.M. Isa, M.S. Najdenov, P. Čižman, M. Unuk, S. Finlayson, H. Dramowski, A. Maté-Cano, I. Soto, B. Calvo, C. Santiago, B. Saavedra-Lozano, J. Bustinza, A. Escosa-García, L. Ureta, N. Tagarro, A. Barrero, P.T. Rincon-Lopez, E.M. Abubakar, I. Aston, J. Heginbothom, M. Satodia, P. Garbash, M. Johnson, A. Sharpe, D. Barton, C. Menson, E. Arenas-Lopez, S. Luck, S. Doerholt, K. McMaster, P. Caldwell, N.A. Lunn, A. Drysdale, S.B. Howe, R. Scorrer, T. Gahleitner, F. Gupta, R. Nash, C. Alexander, J. Raman, M. Bell, E. Rajagopal, V. Kohlhoff, S. Cox, E. Zaoutis, T. ARPEC project group

Abstract

Objectives: Previously, web-based tools for cross-sectional antimicrobial point prevalence surveys (PPSs) have been used in adults to develop indicators of quality improvement. We aimed to determine the feasibility of developing similar quality indicators of improved antimicrobial prescribing focusing specifically on hospitalized neonates and children worldwide. Methods: A standardized antimicrobial PPS method was employed. Included were all inpatient children and neonates receiving an antimicrobial at 8:00 am on the day of the PPS. Denominators included the total number of inpatients. A web-based application was used for data entry, validation and reporting. We analysed 2012 data from 226 hospitals (H) in 41 countries (C) from Europe (174H; 24C), Africa (6H; 4C), Asia (25H; 8C), Australia (6H), Latin America (11H; 3C) and North America (4H). Results: Of 17 693 admissions, 6499 (36.7%) inpatients received at least one antimicrobial, but this varied considerably between wards and regions. Potential indicators included very high broad-spectrum antibiotic prescribing in children of mainly ceftriaxone (ranked first in Eastern Europe, 31.3%; Asia, 13.0%; Southern Europe, 9.8%), cefepime (ranked third in North America, 7.8%) and meropenem (ranked first in Latin America, 13.1%). The survey identified worryingly high use of critically important antibiotics for hospital-acquired infections in neonates (34.9%; range from 14.2% in Africa to 68.0% in Latin America) compared with children (28.3%; range from 14.5% in Africa to 48.9% in Latin America). Parenteral administration was very common among children in Asia (88%), Latin America (81%) and Europe (67%). Documentation of the reasons for antibiotic prescribing was lowest in Latin America (52%). Prolonged surgical prophylaxis rates ranged from 78% (Europe) to 84% (Latin America). Conclusions: Simple web-based PPS tools provide a feasible method to identify areas for improvement of antibiotic use, to set benchmarks and to monitor future interventions in hospitalized neonates and children. To our knowledge, this study has derived the first global quality indicators for antibiotic use in hospitalized neonates and children. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.

Published
2016

45. Variation in paediatric hospital antibiotic guidelines in Europe

Author

Spyridis, N. Syridou, G. Goossens, H. Versporten, A. Kopsidas, J. Kourlaba, G. Bielicki, J. Drapier, N. Zaoutis, T. Tsolia, M. Sharland, M. Vergison, A. Léon, V. Delestrait, M. Huza, C. Lepage, P. Mahieu, L. Boy, T. Jansens, H. Van Der Linden, D. Briquet, C. Allegaert, K. Smits, A. Gabriels, P. Vuye, A. Lutsar, I. Tamm, E. Larionova, A. Laan, D. Orbach, M. Lorrot, M. Angoulvant, F. Prot-Labarthe, S. Dubos, F. Lagree, M. Hufnagel, M. Schuster, K. Henneke, P. Roilides, E. Iosifidis, E. Corovessi, V. Michos, A. Galanakis, E. Gkentzi, D. Giacquinto, C. Longo, G. Dona, D. Mion, T. D'Argenio, P. Degli, M.L.C. De Luca, M. Ciliento, G. Esposito, S. Danieli, E. Montinaro, V. Tenconi, R. Nicolini, G. Sviestina, C.I.M. Pavare, J. Rasnaca, K. Gardovska, D. Usonis, V. Grope, I. Gurksniene, V. Eidukaite, A. Biver, A. Brett, A. Esteves, I. Cambrea, S.C. Craiu, M. Tomescu, E. Cizman, M. Babnik, J. Kenda, R. Vidmar, I. Nunez-Cuadros, E. Rojo, P. Lopez-Varela, E. Ureta, N. Perez-Lopez, A. Mosqueda, R. Orta, L. Santos, M. Navarro, M. Santiago, B. Hernandez-Sampelaya, T. Saavedra, J. Pineiro, R. Torel, P. Cano, I.M. Baumann, P. Berger, C. Menson, E. Botgros, A. Doerholt, K. Drysdale, S. Makwana, N. McCorry, A. Garbash, E.M. Chetcutiganado, C. McLeod, M. Caldwell, N. Nash, C. McCullagh, B. Sharpe, D. Tweddell, L. Liese, J.G. Aston, J. Gallagher, A. Satodia, P. Howard-Smith, N. Korinteli, I. Tavchioska, G. Jensen, L. Trethon, A. Unuk, S. Childs, N. Canlas, J.

Abstract

Objective: To assess the availability and source of guidelines for common infections in European paediatric hospitals and determine their content and characteristics. Design: Participating hospitals completed an online questionnaire on the availability and characteristics of antibiotic prescribing guidelines and on empirical antibiotic treatment including duration of therapy for 5 common infection syndromes: respiratory tract, urinary tract, skin and soft tissue, osteoarticular and sepsis in neonates and children. Results: 84 hospitals from 19 European countries participated in the survey of which 74 confirmed the existence of guidelines. Complete guidelines (existing guidelines for all requested infection syndromes) were reported by 20% of hospitals and the majority (71%) used a range of different sources. Guidelines most commonly available were those for urinary tract infection (UTI) (74%), neonatal sepsis (71%) and sepsis in children (65%). Penicillin and amoxicillin were the antibiotics most commonly recommended for respiratory tract infections (RTIs) (up to 76%), cephalosporin for UTI (up to 50%) and for skin and soft tissue infection (SSTI) and bone infection (20% and 30%, respectively). Antistaphylococcal penicillins were recommended for SSTIs and bone infections in 43% and 36%, respectively. Recommendations for neonatal sepsis included 20 different antibiotic combinations. Duration of therapy guidelines was mostly available for RTI and UTI (82%). A third of hospitals with guidelines for sepsis provided recommendations for length of therapy. Conclusions: Comprehensive antibiotic guideline recommendations are generally lacking from European paediatric hospitals. We documented multiple antibiotics and combinations for most infections. Considerable improvement in the quality of guidelines and their evidence base is required, linking empirical therapy to resistance rates.

Published
2016

46. Abstracts from Hydrocephalus 2016

Author

Adam, A., primary, Robison, J., additional, Lu, J., additional, Jose, R., additional, Badran, N., additional, Vivas-Buitrago, T., additional, Rigamonti, D., additional, Sattar, A., additional, Omoush, O., additional, Hammad, M., additional, Dawood, M., additional, Maghaslah, M., additional, Belcher, T., additional, Carson, K., additional, Hoffberger, J., additional, Jusué Torres, I., additional, Foley, S., additional, Yasar, S., additional, Thai, Q. A., additional, Wemmer, J., additional, Klinge, P., additional, Al-Mutawa, L., additional, Al-Ghamdi, H., additional, Carson, K. A., additional, Asgari, M., additional, de Zélicourt, D., additional, Kurtcuoglu, V., additional, Garnotel, S., additional, Salmon, S., additional, Balédent, O., additional, Lokossou, A., additional, Page, G., additional, Balardy, L., additional, Czosnyka, Z., additional, Payoux, P., additional, Schmidt, E. A., additional, Zitoun, M., additional, Sevestre, M. A., additional, Alperin, N., additional, Baudracco, I., additional, Craven, C., additional, Matloob, S., additional, Thompson, S., additional, Haylock Vize, P., additional, Thorne, L., additional, Watkins, L. D., additional, Toma, A. K., additional, Bechter, Karl, additional, Pong, A. C., additional, Jugé, L., additional, Bilston, L. E., additional, Cheng, S., additional, Bradley, W., additional, Hakim, F., additional, Ramón, J. F., additional, Cárdenas, M. F., additional, Davidson, J. S., additional, García, C., additional, González, D., additional, Bermúdez, S., additional, Useche, N., additional, Mejía, J. A., additional, Mayorga, P., additional, Cruz, F., additional, Martinez, C., additional, Matiz, M. C., additional, Vallejo, M., additional, Ghotme, K., additional, Soto, H. A., additional, Riveros, D., additional, Buitrago, A., additional, Mora, M., additional, Murcia, L., additional, Bermudez, S., additional, Cohen, D., additional, Dasgupta, D., additional, Curtis, C., additional, Domínguez, L., additional, Remolina, A. J., additional, Grijalba, M. A., additional, Whitehouse, K. J., additional, Edwards, R. J., additional, Eleftheriou, A., additional, Lundin, F., additional, Fountas, K. N., additional, Kapsalaki, E. Z., additional, Smisson, H. F., additional, Robinson, J. S., additional, Fritsch, M. J., additional, Arouk, W., additional, Garzon, M., additional, Kang, M., additional, Sandhu, K., additional, Baghawatti, D., additional, Aquilina, K., additional, James, G., additional, Thompson, D., additional, Gehlen, M., additional, Schmid Daners, M., additional, Eklund, A., additional, Malm, J., additional, Gomez, D., additional, Guerra, M., additional, Jara, M., additional, Flores, M., additional, Vío, K., additional, Moreno, I., additional, Rodríguez, S., additional, Ortega, E., additional, Rodríguez, E. M., additional, McAllister, J. P., additional, Guerra, M. M., additional, Morales, D. M., additional, Sival, D., additional, Jimenez, A., additional, Limbrick, D. D., additional, Ishikawa, M., additional, Yamada, S., additional, Yamamoto, K., additional, Junkkari, A., additional, Häyrinen, A., additional, Rauramaa, T., additional, Sintonen, H., additional, Nerg, O., additional, Koivisto, A. M., additional, Roine, R. P., additional, Viinamäki, H., additional, Soininen, H., additional, Luikku, A., additional, Jääskeläinen, J. E., additional, Leinonen, V., additional, Kehler, U., additional, Lilja-Lund, O., additional, Kockum, K., additional, Larsson, E. M., additional, Riklund, K., additional, Söderström, L., additional, Hellström, P., additional, Laurell, K., additional, Kojoukhova, M., additional, Sutela, A., additional, Vanninen, R., additional, Vanha, K. I., additional, Timonen, M., additional, Rummukainen, J., additional, Korhonen, V., additional, Helisalmi, S., additional, Solje, E., additional, Remes, A. M., additional, Huovinen, J., additional, Paananen, J., additional, Hiltunen, M., additional, Kurki, M., additional, Martin, B., additional, Loth, F., additional, Luciano, M., additional, Luikku, A. J., additional, Hall, A., additional, Herukka, S. K., additional, Mattila, J., additional, Lötjönen, J., additional, Alafuzoff, I., additional, Jurjević, I., additional, Miyajima, M., additional, Nakajima, M., additional, Murai, H., additional, Shin, T., additional, Kawaguchi, D., additional, Akiba, C., additional, Ogino, I., additional, Karagiozov, K., additional, Arai, H, additional, Reis, R. C., additional, Teixeira, M. J., additional, Valêncio, C. G., additional, da Vigua, D., additional, Almeida-Lopes, L., additional, Mancini, M. W., additional, Pinto, F. C. G., additional, Maykot, R. H., additional, Calia, G., additional, Tornai, J., additional, Silvestre, S. S. S., additional, Mendes, G., additional, Sousa, V., additional, Bezerra, B., additional, Dutra, P., additional, Modesto, P., additional, Oliveira, M. F., additional, Petitto, C. E., additional, Pulhorn, H., additional, Chandran, A., additional, McMahon, C., additional, Rao, A. S., additional, Jumaly, M., additional, Solomon, D., additional, Moghekar, A., additional, Relkin, N., additional, Hamilton, M., additional, Katzen, H., additional, Williams, M., additional, Bach, T., additional, Zuspan, S., additional, Holubkov, R., additional, Rigamonti, A., additional, Clemens, G., additional, Sharkey, P., additional, Sanyal, A., additional, Sankey, E., additional, Rigamonti, K., additional, Naqvi, S., additional, Hung, A., additional, Schmidt, E., additional, Ory-Magne, F., additional, Gantet, P., additional, Guenego, A., additional, Januel, A. C., additional, Tall, P., additional, Fabre, N., additional, Mahieu, L., additional, Cognard, C., additional, Gray, L., additional, Buttner-Ennever, J. A., additional, Takagi, K., additional, Onouchi, K, additional, Thompson, S. D., additional, Thorne, L. D., additional, Tully, H. M., additional, Wenger, T. L., additional, Kukull, W. A., additional, Doherty, D., additional, Dobyns, W. B., additional, Moran, D., additional, Vakili, S., additional, Patel, M. A., additional, Elder, B., additional, Goodwin, C. R., additional, Crawford, J. A., additional, Pletnikov, M. V., additional, Xu, J., additional, Blitz, A., additional, Herzka, D. A., additional, Guerrero-Cazares, H., additional, Quiñones-Hinojosa, A., additional, Mori, S., additional, Saavedra, P., additional, Treviño, H., additional, Maitani, K., additional, Ziai, W. C., additional, Eslami, V., additional, Nekoovaght-Tak, S., additional, Dlugash, R., additional, Yenokyan, G., additional, McBee, N., additional, and Hanley, D. F., additional

Published
2017
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49. Abstracts from Hydrocephalus 2016.

Author

Adam, A, Robison, J, Lu, J, Jose, R, Badran, N, Vivas-Buitrago, T, Rigamonti, D, Sattar, A, Omoush, O, Hammad, M, Dawood, M, Maghaslah, M, Belcher, T, Carson, K, Hoffberger, J, Jusué Torres, I, Foley, S, Yasar, S, Thai, Q A, Wemmer, J, Klinge, P, Al-Mutawa, L, Al-Ghamdi, H, Carson, K A, Asgari, M, de Zélicourt, D, Kurtcuoglu, V, Garnotel, S, Salmon, S, Balédent, O, Lokossou, A, Page, G, Balardy, L, Czosnyka, Z, Payoux, P, Schmidt, E A, Zitoun, M, Sevestre, M A, Alperin, N, Baudracco, I, Craven, C, Matloob, S, Thompson, S, Haylock Vize, P, Thorne, L, Watkins, L D, Toma, A K, Bechter, Karl, Pong, A C, Jugé, L, Bilston, L E, Cheng, S, Bradley, W, Hakim, F, Ramón, J F, Cárdenas, M F, Davidson, J S, García, C, González, D, Bermúdez, S, Useche, N, Mejía, J A, Mayorga, P, Cruz, F, Martinez, C, Matiz, M C, Vallejo, M, Ghotme, K, Soto, H A, Riveros, D, Buitrago, A, Mora, M, Murcia, L, Bermudez, S, Cohen, D, Dasgupta, D, Curtis, C, Domínguez, L, Remolina, A J, Grijalba, M A, Whitehouse, K J, Edwards, R J, Eleftheriou, A, Lundin, F, Fountas, K N, Kapsalaki, E Z, Smisson, H F, Robinson, J S, Fritsch, M J, Arouk, W, Garzon, M, Kang, M, Sandhu, K, Baghawatti, D, Aquilina, K, James, G, Thompson, D, Gehlen, M, Schmid Daners, M, Eklund, A, Malm, J, Gomez, D, Guerra, M, Jara, M, Flores, M, Vío, K, Moreno, I, Rodríguez, S, Ortega, E, Rodríguez, E M, McAllister, J P, Guerra, M M, Morales, D M, Sival, D, Jimenez, A, Limbrick, D D, Ishikawa, M, Yamada, S, Yamamoto, K, Junkkari, A, Häyrinen, A, Rauramaa, T, Sintonen, H, Nerg, O, Koivisto, A M, Roine, R P, Viinamäki, H, Soininen, H, Luikku, A, Jääskeläinen, J E, Leinonen, V, Kehler, U, Lilja-Lund, O, Kockum, K, Larsson, Elna-Marie, Riklund, K, Söderström, L, Hellström, P, Laurell, K, Kojoukhova, M, Sutela, A, Vanninen, R, Vanha, K I, Timonen, M, Rummukainen, J, Korhonen, V, Helisalmi, S, Solje, E, Remes, A M, Huovinen, J, Paananen, J, Hiltunen, M, Kurki, M, Martin, B, Loth, F, Luciano, M, Luikku, A J, Hall, A, Herukka, S K, Mattila, J, Lötjönen, J, Alafuzoff, Irina, Jurjević, I, Miyajima, M, Nakajima, M, Murai, H, Shin, T, Kawaguchi, D, Akiba, C, Ogino, I, Karagiozov, K, Arai, H, Reis, R C, Teixeira, M J, Valêncio, C G, da Vigua, D, Almeida-Lopes, L, Mancini, M W, Pinto, F C G, Maykot, R H, Calia, G, Tornai, J, Silvestre, S S S, Mendes, G, Sousa, V, Bezerra, B, Dutra, P, Modesto, P, Oliveira, M F, Petitto, C E, Pulhorn, H, Chandran, A, McMahon, C, Rao, A S, Jumaly, M, Solomon, D, Moghekar, A, Relkin, N, Hamilton, M, Katzen, H, Williams, M, Bach, T, Zuspan, S, Holubkov, R, Rigamonti, A, Clemens, G, Sharkey, P, Sanyal, A, Sankey, E, Rigamonti, K, Naqvi, S, Hung, A, Schmidt, E, Ory-Magne, F, Gantet, P, Guenego, A, Januel, A C, Tall, P, Fabre, N, Mahieu, L, Cognard, C, Gray, L, Buttner-Ennever, J A, Takagi, K, Onouchi, K, Thompson, S D, Thorne, L D, Tully, H M, Wenger, T L, Kukull, W A, Doherty, D, Dobyns, W B, Moran, D, Vakili, S, Patel, M A, Elder, B, Goodwin, C R, Crawford, J A, Pletnikov, M V, Xu, J, Blitz, A, Herzka, D A, Guerrero-Cazares, H, Quiñones-Hinojosa, A, Mori, S, Saavedra, P, Treviño, H, Maitani, K, Ziai, W C, Eslami, V, Nekoovaght-Tak, S, Dlugash, R, Yenokyan, G, McBee, N, Hanley, D F, Adam, A, Robison, J, Lu, J, Jose, R, Badran, N, Vivas-Buitrago, T, Rigamonti, D, Sattar, A, Omoush, O, Hammad, M, Dawood, M, Maghaslah, M, Belcher, T, Carson, K, Hoffberger, J, Jusué Torres, I, Foley, S, Yasar, S, Thai, Q A, Wemmer, J, Klinge, P, Al-Mutawa, L, Al-Ghamdi, H, Carson, K A, Asgari, M, de Zélicourt, D, Kurtcuoglu, V, Garnotel, S, Salmon, S, Balédent, O, Lokossou, A, Page, G, Balardy, L, Czosnyka, Z, Payoux, P, Schmidt, E A, Zitoun, M, Sevestre, M A, Alperin, N, Baudracco, I, Craven, C, Matloob, S, Thompson, S, Haylock Vize, P, Thorne, L, Watkins, L D, Toma, A K, Bechter, Karl, Pong, A C, Jugé, L, Bilston, L E, Cheng, S, Bradley, W, Hakim, F, Ramón, J F, Cárdenas, M F, Davidson, J S, García, C, González, D, Bermúdez, S, Useche, N, Mejía, J A, Mayorga, P, Cruz, F, Martinez, C, Matiz, M C, Vallejo, M, Ghotme, K, Soto, H A, Riveros, D, Buitrago, A, Mora, M, Murcia, L, Bermudez, S, Cohen, D, Dasgupta, D, Curtis, C, Domínguez, L, Remolina, A J, Grijalba, M A, Whitehouse, K J, Edwards, R J, Eleftheriou, A, Lundin, F, Fountas, K N, Kapsalaki, E Z, Smisson, H F, Robinson, J S, Fritsch, M J, Arouk, W, Garzon, M, Kang, M, Sandhu, K, Baghawatti, D, Aquilina, K, James, G, Thompson, D, Gehlen, M, Schmid Daners, M, Eklund, A, Malm, J, Gomez, D, Guerra, M, Jara, M, Flores, M, Vío, K, Moreno, I, Rodríguez, S, Ortega, E, Rodríguez, E M, McAllister, J P, Guerra, M M, Morales, D M, Sival, D, Jimenez, A, Limbrick, D D, Ishikawa, M, Yamada, S, Yamamoto, K, Junkkari, A, Häyrinen, A, Rauramaa, T, Sintonen, H, Nerg, O, Koivisto, A M, Roine, R P, Viinamäki, H, Soininen, H, Luikku, A, Jääskeläinen, J E, Leinonen, V, Kehler, U, Lilja-Lund, O, Kockum, K, Larsson, Elna-Marie, Riklund, K, Söderström, L, Hellström, P, Laurell, K, Kojoukhova, M, Sutela, A, Vanninen, R, Vanha, K I, Timonen, M, Rummukainen, J, Korhonen, V, Helisalmi, S, Solje, E, Remes, A M, Huovinen, J, Paananen, J, Hiltunen, M, Kurki, M, Martin, B, Loth, F, Luciano, M, Luikku, A J, Hall, A, Herukka, S K, Mattila, J, Lötjönen, J, Alafuzoff, Irina, Jurjević, I, Miyajima, M, Nakajima, M, Murai, H, Shin, T, Kawaguchi, D, Akiba, C, Ogino, I, Karagiozov, K, Arai, H, Reis, R C, Teixeira, M J, Valêncio, C G, da Vigua, D, Almeida-Lopes, L, Mancini, M W, Pinto, F C G, Maykot, R H, Calia, G, Tornai, J, Silvestre, S S S, Mendes, G, Sousa, V, Bezerra, B, Dutra, P, Modesto, P, Oliveira, M F, Petitto, C E, Pulhorn, H, Chandran, A, McMahon, C, Rao, A S, Jumaly, M, Solomon, D, Moghekar, A, Relkin, N, Hamilton, M, Katzen, H, Williams, M, Bach, T, Zuspan, S, Holubkov, R, Rigamonti, A, Clemens, G, Sharkey, P, Sanyal, A, Sankey, E, Rigamonti, K, Naqvi, S, Hung, A, Schmidt, E, Ory-Magne, F, Gantet, P, Guenego, A, Januel, A C, Tall, P, Fabre, N, Mahieu, L, Cognard, C, Gray, L, Buttner-Ennever, J A, Takagi, K, Onouchi, K, Thompson, S D, Thorne, L D, Tully, H M, Wenger, T L, Kukull, W A, Doherty, D, Dobyns, W B, Moran, D, Vakili, S, Patel, M A, Elder, B, Goodwin, C R, Crawford, J A, Pletnikov, M V, Xu, J, Blitz, A, Herzka, D A, Guerrero-Cazares, H, Quiñones-Hinojosa, A, Mori, S, Saavedra, P, Treviño, H, Maitani, K, Ziai, W C, Eslami, V, Nekoovaght-Tak, S, Dlugash, R, Yenokyan, G, McBee, N, and Hanley, D F

Published
2017
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