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16 results on '"Maheshwari, Deepti"'

2. Severe disease during both primary and secondary dengue virus infections in pediatric populations

Author

Aggarwal, Charu, Ahmed, Hasan, Sharma, Pragati, Reddy, Elluri Seetharami, Nayak, Kaustuv, Singla, Mohit, Maheshwari, Deepti, Chawla, Yadya M., Panda, Harekrushna, Rai, Ramesh Chandra, Gunisetty, Sivaram, Priyamvada, Lalita, Bhaumik, Siddhartha Kumar, Ahamed, Syed Fazil, Vivek, Rosario, Bhatnagar, Priya, Singh, Prabhat, Kaur, Manpreet, Dixit, Kritika, Kumar, Sanjeev, Gottimukkala, Kamal, Saini, Keshav, Bajpai, Prashant, Sreekanth, Gopinathan Pillai, Mammen, Shobha, Rajan, Anand, Verghese, Valsan Philip, Abraham, Asha Mary, Shah, Paresh, Alagarasu, Kalichamy, Yu, Tianwei, Davis, Carl W., Wrammert, Jens, Ansari, Aftab, Antia, Rustom, Kabra, Sushil Kumar, Medigeshi, Guruprasad R., Ahmed, Rafi, Lodha, Rakesh, Shet, Anita, Chandele, Anmol, and Murali-Krishna, Kaja

Published
2024
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4. Contrasting behavior between the three human monocyte subsets in dengue pathophysiology

Author

Maheshwari, Deepti, Saini, Keshav, Singh, Prabhat, Singla, Mohit, Nayak, Kaustuv, Aggarwal, Charu, Chawla, Yadya M., Bajpai, Prashant, Kaur, Manpreet, Gunisetty, Sivaram, Eberhardt, Christiane S., Nyodu, Rajni, Moore, Kathryn, Suthar, Mehul S., Medigeshi, Guruprasad R., Anderson, Evan, Lodha, Rakesh, Kabra, Sushil K., Ahmed, Rafi, Chandele, Anmol, and Murali-Krishna, Kaja

Published
2022
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6. Functional and transcriptional heterogeneity within the massively expanding HLADR + CD38 + CD8 T cell population in acute febrile dengue patients

Author

Singh, Prabhat, primary, Bajpai, Prashant, additional, Maheshwari, Deepti, additional, Chawla, Yadya M., additional, Saini, Keshav, additional, Reddy, Elluri Seetharami, additional, Gottimukkala, Kamalvishnu, additional, Nayak, Kaustuv, additional, Gunisetty, Sivaram, additional, Aggarwal, Charu, additional, Jain, Shweta, additional, Verma, Chaitanya, additional, Singla, Paras, additional, Soneja, Manish, additional, Wig, Naveet, additional, Murali-Krishna, Kaja, additional, and Chandele, Anmol, additional

Published
2023
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8. Analysis of dengue specific memory B cells, neutralizing antibodies and binding antibodies in healthy adults from India

Author

Gunisetty, Sivaram, Nayak, Kaustuv, Chandra Rai, Ramesh, Chawla, Yadya, Reddy, Elluri Seetharami, Aggarwal, Charu, Maheshwari, Deepti, Panda, Harekrushna, Ansari, Nasim Akhtar, Singh, Prabhat, Kaur, Manpreet, Dixit, Kritika, Sharma, Pragati, Bhatnagar, Priya, Priyamvada, Lalita, Bhaumik, Siddhartha Kumar, Ahamed, Syed Fazil, Vivek, Rosario, Ray, Pratima, Shet, Anita, Coshic, Poonam, Lodha, Rakesh, Kabra, Sushil Kumar, Afroze, Dil, Yousuf, Adfar, Ahmed, Rafi, Murali-Krishna, Kaja, and Chandele, Anmol

Published
2019
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9. Immunophenotyping and Transcriptional Profiling of Human Plasmablasts in Dengue

Author

Aggarwal, Charu, primary, Saini, Keshav, additional, Reddy, Elluri Seetharami, additional, Singla, Mohit, additional, Nayak, Kaustuv, additional, Chawla, Yadya M., additional, Maheshwari, Deepti, additional, Singh, Prabhat, additional, Sharma, Pragati, additional, Bhatnagar, Priya, additional, Kumar, Sanjeev, additional, Gottimukkala, Kamalvishnu, additional, Panda, Harekrushna, additional, Gunisetty, Sivaram, additional, Davis, Carl W., additional, Kissick, Haydn Thomas, additional, Kabra, Sushil Kumar, additional, Lodha, Rakesh, additional, Medigeshi, Guruprasad R., additional, Ahmed, Rafi, additional, Murali-Krishna, Kaja, additional, and Chandele, Anmol, additional

Published
2021
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11. Human immunity to chikungunya infection

Author

NAYAK, KAUSTUV, primary, Jain, Vineet, additional, Kaur, Manpreet, additional, Khan, Naushad, additional, Rai, Ramesh Chandra, additional, Dixit, Kritika, additional, Sagar, Rohit, additional, Gupta, Shipra, additional, Islamuddin, Mohammad, additional, Verma, Anil, additional, Maheshwari, Deepti, additional, Aggarwal, Charu, additional, Chawla, Yadya, additional, Reddy, Elluri Seetharami, additional, Panda, Harekrushna, additional, Sharma, Pragati, additional, Bhatnagar, Priya, additional, Singh, Prabhat, additional, Ratageri, Vinod H, additional, Chandele, Anmol, additional, Ray, Pratima, additional, and Muralikrishna, Kaja, additional

Published
2020
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12. Antibody response patterns in chikungunya febrile phase predict protection versus progression to chronic arthritis

Author

Nayak, Kaustuv, primary, Jain, Vineet, additional, Kaur, Manpreet, additional, Khan, Naushad, additional, Gottimukkala, Kamalvishnu, additional, Aggarwal, Charu, additional, Sagar, Rohit, additional, Gupta, Shipra, additional, Rai, Ramesh Chandra, additional, Dixit, Kritika, additional, Islamuddin, Mohammad, additional, Khan, Wajihul Hasan, additional, Verma, Anil, additional, Maheshwari, Deepti, additional, Chawla, Yadya M., additional, Reddy, Elluri Seetharami, additional, Panda, Harekrushna, additional, Sharma, Pragati, additional, Bhatnagar, Priya, additional, Singh, Prabhat, additional, Raghavendhar B, Siva, additional, Patel, Ashok Kumar, additional, Ratageri, Vinod H., additional, Chandele, Anmol, additional, Ray, Pratima, additional, and Murali-Krishna, Kaja, additional

Published
2020
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16. Functional and transcriptional heterogeneity within the massively expanding HLADR+CD38+ CD8 T cell population in acute febrile dengue patients.

Author

Singh, Prabhat, Bajpai, Prashant, Maheshwari, Deepti, Chawla, Yadya M., Saini, Keshav, Reddy, Elluri Seetharami, Gottimukkala, Kamalvishnu, Nayak, Kaustuv, Gunisetty, Sivaram, Aggarwal, Charu, Jain, Shweta, Verma, Chaitanya, Singla, Paras, Soneja, Manish, Wig, Naveet, Murali-Krishna, Kaja, and Chandele, Anmol

Subjects
*T cells, *CELL populations, *CD8 antigen, *T cell receptors, *DENGUE, *DENGUE viruses, *T-cell exhaustion, *FENITROTHION
Abstract

CD8 T cells are important tools for protection against intracellularly replicating pathogens such as viruses. Previous studies showed that a discrete population of HLADR and CD38-expressing CD8 T cells expands massively during the acute febrile phase of human dengue virus infection--but very few of these cells secrete IFNγ upon in vitro stimulation with dengue peptides. To gain a better understanding of what other cytokines/chemokines do these massively expanding HLADR+CD38+ CD8 T cells express, we performed RNA seq of sorted HLADR+CD38+ CD8 T cell subsets after peptide stimulation. A majority of these peptide-stimulated HLADR+CD38+ CD8 T cells were CD69- IFNγ-, nearly a third were CD69+ IFNγ-, whereas very few (<10%) were CD69+ IFNγ+. The CD69- IFNγ- subset was enriched for the expression of key genes implicated in the negative regulation of T cell receptor (TCR) signaling and T-cell exhaustion, attraction of B cells and other lymphocytes, and cytokines related to Tc17/T-reg lineages or those that are implicated in immunosuppression/immunomodulatory and anti-inflammatory activities and angiogenesis. The CD69+ IFNγ- subset showed enriched transcription of key genes implicated in cytotoxic effector functions as well as costimulatory and signaling adaptors implicated in fine balancing of T cell receptor signaling. The CD69+ IFNγ+ subset largely shared the transcriptional profile with the CD69+ IFNγsubset--but with relatively more pronounced expression along with additional genes such as chemokines XCL1/XCL2. Our findings showing distinct functional subsets among these massively expanding CD8 T cells in dengue CD8 T cells warrant further studies to carefully examine the precise role of these T cell subsets in protection against dengue. [ABSTRACT FROM AUTHOR]

Published
2023
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