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Introduction: Mother-to-child transmission of HIV can occur during pregnancy, labour, or breastfeeding. The first-line regimen for prophylaxis in HIV infected pregnant women is combination of Tenofovir, Lamivudine and Efavirenz (TLE). Aim: To evaluate the safety and efficacy of the TLE regimen in the Prevention of Mother-To-Child Transmission (PMTCT) of HIV. Materials and Methods: The present hospital-based, retrospective cohort study was conducted at ART centre, Prevention of Parent to Child Transmission (PPTCT) centre, and Department of Medicine, SP Medical College, Bikaner from July 2016 to June 2019. HIV positive gravidas, on triple-drug regimen TLE (Tenofovir 300 mg, Lamivudine 300 mg, Efavirenz 600 mg) before conception and, those detected HIV reactive antenatally during study period were included in this study and started on TLE regimen. After delivery, these newborns were given syrup Nevirapine as per the PPTCT guidelines. Infants were tested with Rapid test and PCR for HIV, at six weeks, six months, 12 months, and 18 months of life. Results: Out of 87 pregnant women, enrolled and delivered at the study institute, 85 were live births and two were stillbirths. Out of 85 live-born babies, four have died during infancy and two were lost to follow-up despite repeated counselling. Five babies were referred to nearby Anti-Retroviral Therapy (ART) centers. So, the study followed 74 babies out of which one girl child was found to be positive for HIV-1 at 18 months of age (transmission rate of HIV was 1.35 and efficacy of TLE 98.65%). No major adverse effects of TLE were noted and all women continued TLE. Conclusion: The use of a triple-drug regimen (TLE) declined the risk of transmission of HIV from mother-to-child at negligible level, without drug resistance and with safety and tolerability as compared to single drug.

Introduction: As per the International Diabetes Federation (IDF) statistics, around 463 million people are presently living with diabetes worldwide, and this is anticipated to be 578.4 million by 2030. Awareness regarding diabetes is a major determinant for early detection and prevention of diabetes. Information regarding Knowledge, Attitude, and Practice (KAP) among diabetics from Northwest Rajasthan, India is not readily available. Aim: This study was designed to assess KAP regarding diabetes among patients with Type 2 Diabetes Mellitus (T2DM). Materials and Methods: This hospital based, cross-sectional study was conducted over a period of one and half years from July, 2018 to December, 2019 in a Tertiary Care Center in Northwest Rajasthan, India among 960 patients with T2DM. KAP was assessed by a structured questionnaire derived from a validated set of questionnaires and was categorised as poor, average, and good. Bivariate and multivariate analyses were done to assess the association between diabetes-related KAP and sociodemographic variables. Results: The mean age of the subjects was 55.45±11.64 years. The proportion of good, average, and poor knowledge scores among subjects were 10.83%, 65.84% and 23.33%, respectively. The corresponding values for attitude scores were 9.16%, 74.17% and 16.67%, respectively. Subjects from young age group, urban habitats, higher educational background, upper socioeconomic class, longer duration of diabetes, with a family history of diabetes, those who attended diabetes education program and with higher Body Mass Index (BMI) demonstrated significantly greater KAP score (r=0.73, p=0.001). Better knowledge was associated with a better attitude and practice (r=0.81, p=0.001) and better attitude was associated with better practice (r=0.77, p=0.001). Conclusion: The overall level of KAP regarding diabetes was average. To prevent diabetes and its complications, there is an urgent need to carry out extensive awareness programs with a prioritised focus on poorer, rural and less educated groups.

Introduction: The differential diagnoses of patients hospitalised for Influenza-Like Illness (ILI) due to swine influenza virus vs other pathogens are challenging. Aim: To evaluate haematological indices such as lymphocyte (LYM), platelet (PLT), Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Lymphocyte multiplied by Platelet Count (LYM×PLT) as potential indicators to discriminate swine influenza virus infection from another ILI in Adults. Materials and Methods: This study was conducted among 332 patients, admitted with ILI from January 2019 to December 2019. Complete Blood Count (CBC) and Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) to detect swine influenza virus from throat/nasal swab were performed in each patient. Based on results, patients were divided into swine influenza-positive and swine influenza-negative groups. ANOVA test was used to compare different groups. The diagnostic values of the haematological indices in swine influenza infection were evaluated, using the ROC curve. p-value