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657 results on '"Maher, Michael M."'

11. Randomized placebo controlled trial evaluating the safety and efficacy of single low-dose intracoronary insulin-like growth factor following percutaneous coronary intervention in acute myocardial infarction (RESUS-AMI)

Author

Caplice, Noel M., DeVoe, Mary C., Choi, Janet, Dahly, Darren, Murphy, Theodore, Spitzer, Ernest, Van Geuns, Robert, Maher, Michael M., Tuite, David, Kerins, David M., Ali, Mohammed T., Kalyar, Imtiaz, Fahy, Eoin F., Khider, Wisam, Kelly, Peter, Kearney, Peter P., Curtin, Ronan J., O’Shea, Conor, Vaughan, Carl J., Eustace, Joseph A., and McFadden, Eugene P.

Published
2018
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17. Paediatric Thoracic Imaging in Cystic Fibrosis in the Era of Cystic Fibrosis Transmembrane Conductance Regulator Modulation.

Author

O'Regan, Patrick W., Stevens, Niamh E., Logan, Niamh, Ryan, David J., and Maher, Michael M.

Subjects
CHEST (Anatomy), DISEASE progression, CHEST X rays, LIFE expectancy, PEDIATRICS, MAGNETIC resonance imaging, INDIVIDUALIZED medicine, CYSTIC fibrosis, RADIATION doses, POSITRON emission tomography, QUALITY assurance, MEMBRANE proteins, COMPUTED tomography, SENSITIVITY & specificity (Statistics), DISEASE exacerbation
Abstract

Cystic fibrosis (CF) is one of the most common progressive life-shortening genetic conditions worldwide. Ground-breaking translational research has generated therapies that target the primary cystic fibrosis transmembrane conductance regulator (CFTR) defect, known as CFTR modulators. A crucial aspect of paediatric CF disease is the development and progression of irreversible respiratory disease in the absence of clinical symptoms. Accurate thoracic diagnostics have an important role to play in this regard. Chest radiographs are non-specific and insensitive in the context of subtle changes in early CF disease, with computed tomography (CT) providing increased sensitivity. Recent advancements in imaging hardware and software have allowed thoracic CTs to be acquired in paediatric patients at radiation doses approaching that of a chest radiograph. CFTR modulators slow the progression of CF, reduce the frequency of exacerbations and extend life expectancy. In conjunction with advances in CT imaging techniques, low-dose thorax CT will establish a central position in the routine care of children with CF. International guidelines regarding the choice of modality and timing of thoracic imaging in children with CF are lagging behind these rapid technological advances. The continued progress of personalised medicine in the form of CFTR modulators will promote the emergence of personalised radiological diagnostics. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Analytic Morphomics in Myositis-Related Interstitial Lung Disease.

Author

O'Mahony, Alexander T., Henry, Patrick J., Coghlan, Patrick, Waldron, Michael, Crowley, Claire, Ryan, David, Moore, Niamh, Bennett, Deirdre M., O'Connor, Owen J., Maher, Michael M., and Henry, Michael T.

Subjects
INTERSTITIAL lung diseases, ERECTOR spinae muscles, CROSS-sectional imaging, BODY composition, PULMONARY function tests, COMPUTED tomography
Abstract

Purpose: Interstitial lung disease (ILD) is the most common non-musculoskeletal manifestation of idiopathic inflammatory myopathies (IIM). Identification of body composition change may enable early intervention to improve prognosis. We investigated muscle quantity and quality derived from cross-sectional imaging in IIM, and its relationship to ILD severity. Methods: A retrospective cohort study assessing IIM of ILD patients (n = 31) was conducted. Two datasets separated in time were collected, containing demographics, biochemical data, pulmonary function testing and thoracic CT data. Morphomic analysis of muscle quantity (cross-sectional area) and quality (density in Hounsfield Units) on thoracic CT were analysed utilising a web-based tool allowing segmentation of muscle and fat. Bilateral erector spinae and pectoralis muscle (ESM&PM) were measured at defined vertebral levels. Results: FVC and DLCO decreased but within acceptable limits of treatment response (FVC: 83.7–78.7%, p < 0.05, DLCO 63.4–60.6%, p < 0.05). The cross-sectional area of the PM and ESM increased (PM: 39.8 to 40.7 cm2, p = 0.491; ESM: 35.2 to 39.5 cm2, p = 0.098). Density significantly fell for both the PM and ESM (PM: 35.3–31 HU, p < 0.05; ESM: 38–33.7, p < 0.05). Subcutaneous fat area increased from 103.9 to 136.1 cm2 (p < 0.05), while the visceral fat area increased but not reaching statistical significance. The change in PM density between time points demonstrated an inverse correlation with DLCO (p < 0.05, R = − 0.49). Conclusion: Patients with IIM ILD demonstrated significant body composition changes on CT imaging unlikely to be detected by traditional measurement tools. An increase in muscle area with an inverse decrease in density suggests poor muscle quality. [ABSTRACT FROM AUTHOR]

Published
2023
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