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21 results on '"Mahar, Ernestine A."'

1. Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

Author

Hoang, Timothy N., Pino, Maria, Boddapati, Arun K., Viox, Elise G., Starke, Carly E., Upadhyay, Amit A., Gumber, Sanjeev, Nekorchuk, Michael, Busman-Sahay, Kathleen, Strongin, Zachary, Harper, Justin L., Tharp, Gregory K., Pellegrini, Kathryn L., Kirejczyk, Shannon, Zandi, Keivan, Tao, Sijia, Horton, Tristan R., Beagle, Elizabeth N., Mahar, Ernestine A., Lee, Michelle Y.H., Cohen, Joyce, Jean, Sherrie M., Wood, Jennifer S., Connor-Stroud, Fawn, Stammen, Rachelle L., Delmas, Olivia M., Wang, Shelly, Cooney, Kimberly A., Sayegh, Michael N., Wang, Lanfang, Filev, Peter D., Weiskopf, Daniela, Silvestri, Guido, Waggoner, Jesse, Piantadosi, Anne, Kasturi, Sudhir P., Al-Shakhshir, Hilmi, Ribeiro, Susan P., Sekaly, Rafick P., Levit, Rebecca D., Estes, Jacob D., Vanderford, Thomas H., Schinazi, Raymond F., Bosinger, Steven E., and Paiardini, Mirko

Published
2021
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2. Cost-effectiveness of use of 20-valent pneumococcal conjugate vaccine among adults in Germany

Author

Kühne, Felicitas, primary, Achtert, Katharina, additional, Püschner, Franziska, additional, Urbanski-Rini, Dominika, additional, Schiller, Juliane, additional, Mahar, Ernestine, additional, Friedrich, Josephine, additional, Atwood, Mark, additional, Sprenger, Ralf, additional, Vietri, Jeffrey, additional, von Eiff, Christof, additional, and Theilacker, Christian, additional

Published
2023
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3. Circulating progenitor cells and coronary microvascular dysfunction: Results from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation – Coronary Vascular Dysfunction Study (WISE-CVD)

Author

Mekonnen, Girum, Hayek, Salim S., Mehta, Puja K., Li, Qunna, Mahar, Ernestine, Mou, Liping, Kenkre, Tanya S., Petersen, John W., Azarbal, Babak, Samuels, Bruce, Anderson, R. David, Sedlak, Tara, Zaya, Melody, Agarwal, Megha, Haftbaradaran, Afsaneh, Minissian, Margo, Handberg, Eileen, Pepine, Carl J., Cogle, Christopher R., Bairey Merz, C. Noel, Waller, Edmund K., and Quyyumi, Arshed A.

Published
2016
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4. Mathematical modeling of pneumococcal transmission dynamics in response to PCV13 infant vaccination in Germany predicts increasing IPD burden due to serotypes included in next-generation PCVs

Author

Horn, Matthias, primary, Theilacker, Christian, additional, Sprenger, Ralf, additional, von Eiff, Christof, additional, Mahar, Ernestine, additional, Schiffner-Rohe, Julia, additional, Pletz, Mathias W., additional, van der Linden, Mark, additional, and Scholz, Markus, additional

Published
2023
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6. Progenitor Cells and Clinical Outcomes in Patients With Acute Coronary Syndromes

Author

Samman Tahhan, Ayman, Hammadah, Muhammad, Raad, Mohamad, Almwaqqat, Zakaria, Alkhoder, Ayman, Sandesara, Pratik B., Mohamed-Kelli, Heval, Hayek, Salim S., Kim, Jeong Hwan, O’Neal, Wesley T., Topel, Matthew L., Grant, Aubrey J., Sabbak, Nabil, Heinl, Robert E., Gafeer, Mohamad Mazen, Obideen, Malik, Kaseer, Belal, Abdelhadi, Nasser, Ko, Yi-An, Liu, Chang, Hesaroieh, Iraj, Mahar, Ernestine A., Vaccarino, Viola, Waller, Edmund K., and Quyyumi, Arshed A.

Published
2018
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9. Tissue-specific transcriptional profiling of plasmacytoid dendritic cells reveals a hyperactivated state in chronic SIV infection

Author

Lee, Michelle Y.-H., primary, Upadhyay, Amit A., additional, Walum, Hasse, additional, Chan, Chi N., additional, Dawoud, Reem A., additional, Grech, Christine, additional, Harper, Justin L., additional, Karunakaran, Kirti A., additional, Nelson, Sydney A., additional, Mahar, Ernestine A., additional, Goss, Kyndal L., additional, Carnathan, Diane G., additional, Cervasi, Barbara, additional, Gill, Kiran, additional, Tharp, Gregory K., additional, Wonderlich, Elizabeth R., additional, Velu, Vijayakumar, additional, Barratt-Boyes, Simon M., additional, Paiardini, Mirko, additional, Silvestri, Guido, additional, Estes, Jacob D., additional, and Bosinger, Steven E., additional

Published
2021
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10. Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

Author

Hoang, Timothy N., primary, Pino, Maria, additional, Boddapati, Arun K., additional, Viox, Elise G., additional, Starke, Carly E., additional, Upadhyay, Amit A., additional, Gumber, Sanjeev, additional, Busman-Sahay, Kathleen, additional, Strongin, Zachary, additional, Harper, Justin L., additional, Tharp, Gregory K., additional, Pellegrini, Kathryn L., additional, Kirejczyk, Shannon, additional, Zandi, Keivan, additional, Tao, Sijia, additional, Horton, Tristan R., additional, Beagle, Elizabeth N., additional, Mahar, Ernestine A., additional, Lee, Michelle YH, additional, Cohen, Joyce, additional, Jean, Sherrie M., additional, Wood, Jennifer S., additional, Connor-Stroud, Fawn, additional, Stammen, Rachelle L., additional, Delmas, Olivia M., additional, Wang, Shelly, additional, Cooney, Kimberly A., additional, Sayegh, Michael N., additional, Wang, Lanfang, additional, Weiskopf, Daniela, additional, Filev, Peter D., additional, Waggoner, Jesse, additional, Piantadosi, Anne, additional, Kasturi, Sudhir P., additional, Shakhshir, Hilmi Al-, additional, Ribeiro, Susan P., additional, Sekaly, Rafick P., additional, Levit, Rebecca D., additional, Estes, Jacob D., additional, Vanderford, Thomas H., additional, Schinazi, Raymond F., additional, Bosinger, Steven E., additional, and Paiardini, Mirko, additional

Published
2020
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11. The Impact of a Physical Activity Intervention Can be Accurately Assessed By Smart Watches in Patients Completing Autologous Stem Cell Transplantation for Lymphoma or Multiple Myeloma: Results of a Feasibility Study

Author

Ip, Andrew, primary, Churnetski, Michael C, additional, Calzada, Oscar, additional, Chang, Andres, additional, Liu, Yuan, additional, Bumpers, Nassoma, additional, Leeson, Deborah, additional, Mahar, Ernestine, additional, Hesaroieh, Iraj, additional, Crain, Maria, additional, Nooka, Ajay K, additional, Koff, Jean L., additional, Hofmeister, Craig C, additional, Gupta, Vikas A., additional, Allen, Pamela, additional, Lechowicz, Mary Jo, additional, Kaufman, Jonathan L, additional, Blum, Kristie A., additional, Lonial, Sagar, additional, Langston, Amelia, additional, Waller, Edmund K., additional, Flowers, Christopher R, additional, and Cohen, Jonathon B., additional

Published
2018
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12. Sex Differences in Circulating Progenitor Cells

Author

Topel, Matthew L., primary, Hayek, Salim S., additional, Ko, Yi‐An, additional, Sandesara, Pratik B., additional, Samman Tahhan, Ayman, additional, Hesaroieh, Iraj, additional, Mahar, Ernestine, additional, Martin, Greg S., additional, Waller, Edmund K., additional, and Quyyumi, Arshed A., additional

Published
2017
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13. Progenitor Cells and Clinical Outcomes in Patients With Heart Failure

Author

Samman Tahhan, Ayman, primary, Hammadah, Muhammad, additional, Sandesara, Pratik B., additional, Hayek, Salim S., additional, Kalogeropoulos, Andreas P., additional, Alkhoder, Ayman, additional, Mohamed Kelli, Heval, additional, Topel, Matthew, additional, Ghasemzadeh, Nima, additional, Chivukula, Kaavya, additional, Ko, Yi-An, additional, Aida, Hiroshi, additional, Hesaroieh, Iraj, additional, Mahar, Ernestine, additional, Kim, Jonathan H., additional, Wilson, Peter, additional, Shaw, Leslee, additional, Vaccarino, Viola, additional, Waller, Edmund K., additional, and Quyyumi, Arshed A., additional

Published
2017
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14. ASSOCIATION BETWEEN CIRCULATING PROGENITOR CELLS AND OUTCOMES IN PATIENTS WITH CORONARY ARTERY DISEASE

Author

Sandesara, Pratik, primary, Tahhan, Ayman Samman, additional, Khambhati, Jay, additional, Stahl, Eric, additional, Hayek, Salim, additional, Hammadah, Muhammad, additional, Mohamed Kelli, Heval, additional, Topel, Matthew, additional, Alkhoder, Ayman, additional, Chivukula, Kaavya, additional, Aida, Hiroshi, additional, Gafeer, Mohamad Mazen, additional, Abdelhadi, Naser, additional, Hesaroieh, Iraj, additional, Naqvi, Humza, additional, Mahar, Ernestine, additional, Waller, Edmund, additional, Sperling, Laurence, additional, and Quyyumi, Arshed, additional

Published
2017
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15. CENTRAL OBESITY PREDICTS CIRCULATING PROGENITOR CELL LEVELS

Author

Khambhati, Jay, primary, Sandesara, Pratik, additional, Tahhan, Ayman Samman, additional, Topel, Matthew, additional, Corrigan, Frank, additional, Kelli, Heval Mohamad, additional, Stahl, Eric, additional, Allard-Ratick, Marc, additional, Alkhoder, Ayman, additional, Aida, Hiroshi, additional, Gafeer, Mohamad Mazen, additional, Hesaroieh, Iraj, additional, Mahar, Ernestine, additional, Waller, Edmund, additional, Vaccarino, Viola, additional, Ziegler, Thomas R., additional, Sperling, Laurence, additional, Brigham, Kenneth, additional, Martin, Greg, additional, and Quyyumi, Arshed, additional

Published
2017
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16. CIRCULATING PROGENITOR CELLS LEVELS AND OUTCOMES IN ACUTE MYOCARDIAL INFARCTION

Author

Tahhan, Ayman Samman, primary, Almuwaqqat, Zakaria, additional, Sandesara, Pratik, additional, Alkhoder, Ayman, additional, Stahl, Eric, additional, Heinl, Robert, additional, Hayek, Salim, additional, Kelli, Heval Mohamed, additional, Hammadah, Muhammad, additional, Topel, Matthew, additional, Gafeer, Mohamad Mazen, additional, Chivukula, Kaavya, additional, Aida, Hiroshi, additional, Allard-Ratick, Marc, additional, Kindya, Bryan, additional, Abdelhadi, Naser, additional, Naqvi, Humza, additional, Hesaroieh, Iraj, additional, Mahar, Ernestine, additional, and Waller, Edmund, additional

Published
2017
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17. PROGENITOR CELLS AND CLINICAL OUTCOMES IN PATIENTS WITH HEART FAILURE

Author

Tahhan, Ayman Samman, primary, Sandesara, Pratik, additional, Hayek, Salim, additional, Hammadah, Muhammad, additional, Allard-Ratick, Marc, additional, Kindya, Bryan, additional, Kalogeropoulos, Andreas, additional, Kelli, Heval Mohamed, additional, Topel, Matthew, additional, Alkhoder, Ayman, additional, Chivukula, Kaava, additional, Aida, Hiroshi, additional, Gafeer, Mohamad Mazen, additional, Stahl, Eric, additional, Robert, Heinl, additional, Abdelhadi, Naser, additional, Hesaroieh, Iraj, additional, Naqvi, Humza, additional, Mahar, Ernestine, additional, Kim, Jonathan, additional, Wilson, Peter, additional, Shaw, Leslee, additional, Vaccarino, Viola, additional, Waller, Edmund, additional, and Quyyumi, Arshed, additional

Published
2017
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20. Progenitor Cells and Clinical Outcomes in Patients With Heart Failure.

Author

Tahhan, Ayman Samman, Hammadah, Muhammad, Sandesara, Pratik B., Hayek, Salim S., Kalogeropoulos, Andreas P., Alkhoder, Ayman, Kelli, Heval Mohamed, Topel, Matthew, Ghasemzadeh, Nima, Chivukula, Kaavya, Ko, Yi-An, Aida, Hiroshi, Hesaroieh, Iraj, Mahar, Ernestine, Kim, Jonathan H., Wilson, Peter, Shaw, Leslee, Vaccarino, Viola, Waller, Edmund K., and Quyyumi, Arshed A.

Abstract

BACKGROUND: Endogenous regenerative capacity, assessed as circulating progenitor cell (PC) numbers, is an independent predictor of adverse outcomes in patients with cardiovascular disease. However, their predictive role in heart failure (HF) remains controversial. We assessed the relationship between the number of circulating PCs and the pathogenesis and severity of HF and their impact on incident HF events. METHODS AND RESULTS: We recruited 2049 adults of which 651 had HF diagnosis. PCs were enumerated by fow cytometry as CD45med+ blood mononuclear cells expressing CD34, CD133, vascular endothelial growth factor receptor-2, and chemokine (C-X-C motif) receptor 4 epitopes. PC subsets were lower in number in HF and after adjustment for clinical characteristics in multivariable analyses, a low CD34+ and CD34+/ CXCR+ cell count remained independently associated with a diagnosis of HF (P<0.01). PC levels were not signifcantly different in reduced versus preserved ejection fraction patients. In 514 subjects with HF, there were 98 (19.1%) all-cause deaths during a 2.2±1.5-year follow-up. In a Cox regression model adjusting for clinical variables, hematopoietic-enriched PCs (CD34+, CD34+/CD133+, and CD34+/CXCR4+) were independent predictors of all-cause death (hazard ratio 2.0, 1.6, 1.6-fold higher mortality, respectively; P<0.03) among HF patients. Endothelial-enriched PCs (CD34+/VEGF+) were independent predictors of mortality in patients with HF with preserved ejection fraction only (hazard ratio, 5.0; P=0.001). CONCLUSIONS: PC levels are lower in patients with HF, and lower PC counts are strongly and independently predictive of mortality. Strategies to increase PCs and exogenous stem cell therapies designed to improve regenerative capacity in HF, especially, in HF with preserved ejection fraction, need to be further explored. [ABSTRACT FROM AUTHOR]

Published
2017
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21. Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.

Author

Hoang TN, Pino M, Boddapati AK, Viox EG, Starke CE, Upadhyay AA, Gumber S, Busman-Sahay K, Strongin Z, Harper JL, Tharp GK, Pellegrini KL, Kirejczyk S, Zandi K, Tao S, Horton TR, Beagle EN, Mahar EA, Lee MY, Cohen J, Jean SM, Wood JS, Connor-Stroud F, Stammen RL, Delmas OM, Wang S, Cooney KA, Sayegh MN, Wang L, Weiskopf D, Filev PD, Waggoner J, Piantadosi A, Kasturi SP, Al-Shakhshir H, Ribeiro SP, Sekaly RP, Levit RD, Estes JD, Vanderford TH, Schinazi RF, Bosinger SE, and Paiardini M

Abstract

Effective therapeutics aimed at mitigating COVID-19 symptoms are urgently needed. SARS-CoV-2 induced hypercytokinemia and systemic inflammation are associated with disease severity. Baricitinib, a clinically approved JAK1/2 inhibitor with potent anti-inflammatory properties is currently being investigated in COVID-19 human clinical trials. Recent reports suggest that baricitinib may also have antiviral activity in limiting viral endocytosis. Here, we investigated the immunologic and virologic efficacy of baricitinib in a rhesus macaque model of SARS-CoV-2 infection. Viral shedding measured from nasal and throat swabs, bronchoalveolar lavages and tissues was not reduced with baricitinib. Type I IFN antiviral responses and SARS-CoV-2 specific T cell responses remained similar between the two groups. Importantly, however, animals treated with baricitinib showed reduced immune activation, decreased infiltration of neutrophils into the lung, reduced NETosis activity, and more limited lung pathology. Moreover, baricitinib treated animals had a rapid and remarkably potent suppression of alveolar macrophage derived production of cytokines and chemokines responsible for inflammation and neutrophil recruitment. These data support a beneficial role for, and elucidate the immunological mechanisms underlying, the use of baricitinib as a frontline treatment for severe inflammation induced by SARS-CoV-2 infection.

Published
2020
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