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13 results on '"Mahantesh Kurjogi"'

1. Potential role of mitochondrial uncoupling protein 2 as a biomarker in patients with sepsis and septic shock: A prospective observational study

Author

Roopa Sachidananda, Vikram Kemmannu Bhat, Mahantesh Kurjogi, Gulam Nabi L. Vanti, and Madhura Kayara

Subjects
biomarkers, procalcitonin, sepsis, shock, uncoupling protein 2, qsofa, Anesthesiology, RD78.3-87.3
Abstract

Background and Aims: Early diagnosis of sepsis is crucial. The primary objective of this study was to explore the role of uncoupling protein 2 (UCP2) in diagnosing sepsis and septic shock. Methods: This prospective observational study was conducted over 19 months. All adult patients aged more than 18 years with a diagnosis of sepsis or septic shock based on quick sequential organ failure assessment (qSOFA) score were enroled. Blood was drawn for procalcitonin (PCT) and UCP2 on days 0, 3, 7 and 28. Blood samples from 50 healthy volunteers were used as controls. An electrochemiluminescence test was done for PCT. A quantitative enzyme-linked immune sorbent assay was used for UCP2. The Chi-square test was used for qualitative variables and the independent t-test for quantitative variables. The receiver operator characteristic curve was used to evaluate the diagnostic efficacy of UCP2. Results: A total of 128 subjects were included in the study. Out of these, 78 patients (qSOFA score ≥2) were subcategorised into the infection group, sepsis or septic shock group based on the PCT levels. The UCP2 levels in the infection, sepsis or septic shock group were significantly higher than in the control group (P > 0.001). The UCP2 levels correlated with PCT on admission, day 3 and day 7. Conclusion: The UCP2 levels were significantly higher in sepsis and septic shock groups compared to controls and hence could be a potential diagnostic biomarker of sepsis.

Published
2024
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2. Synthesis and Characterization of Multifunctional Chitosan–Silver Nanoparticles: An In-Vitro Approach for Biomedical Applications

Author

Gulamnabi Vanti, Naresh Poondla, Prasath Manogaran, Nagappa Teradal, Veeresh S, Ram Kaulgud, and Mahantesh Kurjogi

Subjects
silver nanoparticles, chitosan, antibacterial activity, antioxidant activity, wound healing activity, Medicine, Pharmacy and materia medica, RS1-441
Abstract

Antibiotics are successful in promoting health quality by preventing various infectious diseases and minimizing mortality and morbidity all over the world. However, the indiscriminate use of antibiotics has led to the emergence of multi-drug-resistant bacteria, which pose a serious threat to health care sector. Therefore, it is necessary to develop novel antimicrobial agents with versatile characteristics, such as antibacterial activity, low toxicity, wound healing potency, and antioxidant property. In this context, silver chitosan nanoparticles were synthesized in the present study, and their physical characterization revealed that the size of synthesized chitosan–silver nanoparticles was 14–25 nm, with positive surface charge. The functional groups and crystalline nature of the nanoparticles were confirmed by FT-IR and XRD analysis. Further, the silver chitosan nanoparticles showed antibacterial activity against two important clinical pathogens, S. aureus and E. coli. The MTT assay carried out in the present study showed that the synthesized nanoparticles are non-toxic to host cells. A scratch assay on fibroblast cells (L292) demonstrated that the silver chitosan nanoparticles showed promising wound healing activity. A fluorescent DCFH-DA staining assay revealed anantioxidant property of the synthesized nanoparticles. Overall, the study emphasizes the versatile nature of synthesized chitosan–silver nanoparticles, suggesting their great compatibility for biomedical applications.

Published
2024
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4. Ganoderma applanatum-mediated green synthesis of silver nanoparticles: Structural characterization, and in vitro and in vivo biomedical and agrochemical properties

Author

Sudisha Jogaiah, Mahantesh Kurjogi, Mostafa Abdelrahman, Nagabhushana Hanumanthappa, and Lam-Son Phan Tran

Subjects
Chemistry, QD1-999
Abstract

This study presents the use of basidiomycete extracts as an effective platform for “green synthesis” of silver nanoparticles (AgNPs). Out of seven basidiomycete species, Ganoderma applanatum displayed the highest antimicrobial properties against the tested pathogens. Thus, G. applanatum methanol crude extract was fractionated using column chromatography, and the obtained fractions were subjected to an antimicrobial assay followed by phytochemical analyses using high-performance liquid chromatography to select the best fraction for synthesis of AgNPs. Fraction 3 displayed potent antimicrobial activities as evidenced by its high phenolic content, and thus was used for AgNP biosynthesis. The G. applanatum fraction 3-synthesized AgNPs were then characterized using various microscopy, spectroscopy and X-ray diffraction techniques. The characteristic features of the synthesized AgNPs indicated the spherical shape of AgNPs with an average size of 20–25 nm. The synthesized AgNPs exhibit high antioxidant capacity, in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli, and in vivo antifungal properties against Botrytis cinerea and Colletotrichum gloeosporioides in tomato and strawberry leaflet assays, respectively. Our results demonstrated that G. applanatum can be efficiently used in synthesis of AgNPs with potent antimicrobial properties, which can be used for both clinical and agrochemical purposes. Keywords: Green synthesis, Silver nanoparticles, Ganoderma applanatum, Antimicrobial, Antioxidant

Published
2019
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5. Detection and determination of stability of the antibiotic residues in cow's milk.

Author

Mahantesh Kurjogi, Yasser Hussein Issa Mohammad, Saad Alghamdi, Mostafa Abdelrahman, Praveen Satapute, and Sudisha Jogaiah

Subjects
Medicine, Science
Abstract

In the present study, antibiotic residues were detected in milk samples collected from the dairy herds located in Karnataka, India, by microbiological assay. Subsequently, the detected antibiotics were identified as azithromycin and tetracycline, by high-performance liquid chromatography, further both the antibiotics detected in the cow milk samples were found to be at high concentration (9708.7 and 5460 μg kg-1, respectively). We then investigated the effects of temperature and pH on the stabilities of azithromycin and tetracycline to determine the degradation rate constant k using first-order kinetic equation. Results indicated that significant reduction in stability and antibacterial activity of azithromycin solution when subjected to 70 and 100°C for 24 h. While stability of tetracycline was significantly reduced when subjected to 70 and 100°C for 24 h. However no significant reduction in antibacterial activity of tetracycline was observed at respective temperatures when compared with that of control. In addition, the stabilities of azithromycin and tetracycline were found to be decreased in acidic pH 4-5. The results of the present study revealed the high risk of contamination of milk sample with veterinary antibiotics and also demonstrated the effect of temperature and pH on stability of antibiotics. Therefore the study suggest that the qualitative and quantitative screening of milk for the presence of antibiotics need to be strictly performed to ensure safe drinking milk for consumers.

Published
2019
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6. Sustainable biopolymer coupled silver nanoparticles synthesis, characterization and their efficacy in wound healing

Author

Mahantesh Kurjogi, Segula Masaphy, Ram S. Kaulgud, Nagappa Teradal, and Gulamnabi Vanti

Abstract

Silver is traditionally known for its antimicrobial activity, especially in the treatment of topical wound infections. However, its application in wound infection is limited because of its toxicity to cells. Thus, it is essential to develop an effective biocompatible method to minimize the toxicity of silver and promote wound healing activity. In this study, chitosan-coupled silver nanoparticles were synthesized in a sustainable manner, and their physicochemical characterization revealed that the synthesized nanoparticles were 14–30 nm nearly spherical in shape with a positive surface charge. The functional group and crystalline nature of nanoparticles were confirmed by FT-IR and XRD studies. Subsequently, nanoparticles showed potent efficiency against clinical pathogens S. aureus and E. coli. Furthermore, cytotoxicity and a wound healing assay against HEK 293 and L292 cells revealed the nontoxic nature of nanoparticles to mammalian cells and also that nanoparticles have the efficacy to heal wounds efficiently. Overall, the current study emphasizes that simple routed Ch-AgNPs could be used in the management of topical wound infections whereby these nanoparticles not only inhibit the growth of infectious pathogens but also promote the proliferation of the cells to the wound area.

Published
2023

8. Contributors

Author

Nadeesh M. Adassooriya, Javed Ahmad, Madhusudhan Alle, null Amna, Rajkumar Bandi, Mahamuda Begum, Bhupal Bhattacharya, Sarmistha Bhattacharya, Jayeeta Chattopadhyay, Anirudha Chattopadhyay, Ramachandran Chelliah, Anuj Choudhary, Ramakrishna Dadigala, Tahir Farooq, Sandra Gonçalves, Leila Hakimi, Amjad Hameed, Arruje Hameed, Yuxiong Huang, Azamal Husen, Claudio Inostroza-Blancheteau, Suchisree Jha, Harmanjot Kaur, Tanzila Khalid, Farin Khatoon, Esmail Khosropour, Antul Kumar, Mahantesh Kurjogi, Atul Loyal, Inamu lHasan Madar, Arvind Malik, Amit Kumar Mandal, Inês Mansinhos, Kanika Mehta, Sahil Mehta, null Nida, Deog Hwan Oh, Bandana Pahi, S.K. Pahuja, Biresh Prasad, Prachi Priyanka, Sadia Qamar, Muhammad Abdul Qayyum, Mohammad Irfan Qureshi, Gonzalo Recio, Zed Rengel, Marjorie Reyes-Díaz, Anabela Romano, Priya Roy, Muhammad Jawwad Saif, Salem S. Salem, Chanaka Sandaruwan, Seema Sangwan, Vijayalakshmi Selvakumar, Pankaj Sharma, Yuxian Shi, Nimmy Srivastava, Rakesh K. Srivastava, Ghazala Sultan, Iftikhar Aslam Tayubi, Ricardo Tighe-Neira, Anne Nilukshi Tissera, Amruta Uppar, Gulamnabi Vanti, J.U. Vinay, Leela Wati, Weria Weisany, Ashok Yadav, and Rubina Yasmine

Published
2023

10. Contributors

Author

Komal Agrawal, Vasilis Andriopoulos, Arnab Atta, Srijoni Banerjee, Jayanta Kumar Biswas, Soma Biswas, Khalida Bloch, Hendrik G. Brink, Pujaa Dange, Bhaskar Das, Swati Das, Suresh Deka, Niteen Desai, Suneel Dodamani, Shubha Dwivedi, Naveen Dwivedi, Shreya Gawas, Makarand M. Ghangrekar, Sougata Ghosh, Subhabrata Ghosh, Mrinmoy Ghosh, Spyros Giannakopoulos, Piyush K. Gupta, Aishwarya Hattiholi, Sk Tofajjen Hossain, Marianne Hull-Cantillo, Santosh K. Jha, Monika Joshi, Subhash Kajla, null Kanupriya, Harvinder K. Khera, Michael Kornaros, Bhupendra Koul, Eleni Koutra, Arpan Kumar, Mahantesh Kurjogi, Mark Lay, Frederick V. Lubbe, Savvas Giannis Mastropetros, Lukhanyo Mekuto, Maggie N.B. Momba, Samir K. Mukherjee, Subhasha Nigam, Sonal Nigam, Olubusola A. Odeniyi, Soumya Pandit, Joginder S. Panwar, Polytimi Papavasileiou, Ravishankar Patil, Sanjukta Patra, Anil K. Poonia, Afshan Rizvi, Susana Rodríguez-Couto, Kurt Rosentrater, Swastika Saha, Myrsini Sakarika, Maulin P. Shah, Rukhsar Shaikh, Poojhaa Shanmugam, Jyoti Sharma, Abhilasha Shourie, Sushil K. Shukla, Jayanta Sikdar, Anamika Singh, Hare R. Singh, Bhaskar Singh, Rachana Singh, Neha Singh, Surbhi Sinha, Varsha Sonkamble, Amit K. Srivastava, John O. Unuofin, Pradeep Verma, U. Vijayalakshmi, Nilesh Wagh, and Thomas J. Webster

Published
2022

11. Contributors

Author

K.N. Basavesha, S.A. Belorkar, Piero Attilio Bianco, S. Brindhadevi, Paola Casati, Raju Krishna Chalannavar, Jishuang Chen, K.S. Divya, Subrata Dutta, Jinggui Fang, N. Geetha, Ankit Kumar Ghorai, Swapan Kumar Ghosh, C. Gourav, H.G. Gowtham, Muhammad Salman Haider, Tran Thi Minh Hang, P. Hariprasad, Vu Quynh Hoa, S.K. Jadhav, Archana Jain, Subhendu Jash, Muhammad Jafar Jaskani, Sudisha Jogaiah, I. Johnson, Neelu Joshi, Veenu Joshi, G. Karthikeyan, M. Karthikeyan, Manzoor R. Khan, S.M. Paul Khurana, Anil Kumar, Narendra Kumar, Vipul Kumar, Belur Satyan Kumudini, Mahantesh Kurjogi, Giuliana Maddalena, K. Mahendra, T. Marimuthu, S. Mahadeva Murthy, Muntazir Mushtaq, S. Nakkeeran, B. Nandini, K. Narasimha Murthy, Atanu Panja, Ghazala Parveen, Alessandro Passera, Savita Veeranagouda Patil, Rakesh Patsa, H.V. Pavan, Hilal Ahmad Pir, K. Prabakar, Fabio Quaglino, T. Raguchander, Kushal Raj, S. Rajamanickam, V. Rajasreelatha, L. Rajendran, Younes M. Rashad, Ruby Rawal, P. Renukadevi, Richa Salwan, Surendra Sarsaiya, Santanu Sasidharan, Prakash Saudagar, V.P. Savalgi, V. Sendhilvel, Vivek Sharma, Jingshan Shi, S.D. Shruthi, Monika Sood, K. Soumya, C. Srinivas, M. Thippeswamy, Silvia Laura Toffolatti, Palistha Tuladhar, A.C. Udayashankar, S.L. Varsha, A.B. Vedamurthy, Amber Vyas, Shabir Hussain Wani, Leela Wati, Vu Hai Yen, and Abbu Zaid

Published
2021

12. Contributors

Author

Adersh Asok, Rajib Bandopadhyay, Ritwik Banerjee, Avishek Banik, Tanay Bhagwat, Satabdi Bhattacharjee, Raju Biswas, Khalida Bloch, Ronita Chandra, Balu A. Chopade, Jayashankar Das, Shivani Dave, Sushma Dave, Suneel Dodamani, Bandita Dutta, Bhramar Dutta, Sayantani Garai, Shreyasi Ghosh, Sougata Ghosh, Prabuddha Gupta, Urmi Halder, Kab-yel Jang, Santosh Kumar Jha, Roymon Joseph, Ashutosh Kabiraj, A. Karthic, K Kaur, Bhaskar Kurangi, Mahantesh Kurjogi, Dibyajit Lahiri, Jaya R. Lakkakula, Hariprasath Lakshmanan, Moitri Let, Leena Louis, Krishnendu Majhi, Akshat Mathur, Mukesh Meena, Haritha Meruvu, Moumita Mondal, Dipro Mukherjee, Indranil Mukherjee, Moupriya Nag, Adhishree Nagda, Ananya Naha, Tejas Oza, Mahendrapalsingh Rajput, Animesh M. Ramachandran, Jegadeesh Raman, Rina Rani Ray, Debanita Roy, Natarajan Sakthivel, Gaurav Sanghvi, Aditya Saran, Shrabana Sarkar, Indu Sharma, Hare Ram Singh, Priyankaraj Sonigra, Nagappa Teradal, Rebecca Thombre, Ujwalkumar Trivedi, Meyappan Vadivel, Nilesh S. Wagh, Thomas J. Webster, and Garima Yadav

Published
2021

13. List of contributors

Author

Roshan Akbarbasha, Qasid Ali, Pandiyan Amuthavalli, Arthur Maffei Angelotti, Jaganathan Anitha, Fauze Ahmad Aouada, Udayashankar C. Arakere, Lal Bahadur, Ramakant Bajpai, Tanmay Bera, Reshu Bhardwaj, Sourav Bhattacharya, Harsimran Singh Bindra, Estefânia Vangelie Ramos Campos, Sonia Chadha, Srinivas Chowdappa, Bo Cui, Haixin Cui, Arijit Das, Sampa Das, Renan da Silva Fernandes, Savitha De Britto, Hudson W. Pereira de Carvalho, Renata de Lima, Márcia Regina de Moura, Jhones Luiz de Oliveira, Devakumar Dinesh, Nádia M. Duran, Marcos H. Feresin Gomes, Carlos Roberto Ferreira Júnior, N. Geetha, Swapan Kumar Ghosh, Ved Prakash Giri, Diego Genuário Gomes, Mariana Guilger-Casagrande, N.K. Hemanth Kumar, Jiang-Shiou Hwang, Akansha Jain, Josef Jampílek, Sudisha Jogaiah, Khalid Mahmood Khawar, Narasimhamurthy Konappa, Katarína Kráľová, Soumya Krishnamurthy, Amritha G. Kulkarni, Mahantesh Kurjogi, T.R. Lakshmeesha, Rakhi Mahto, Aradhana Mishra, Muhamad Mujtaba, Kadarkarai Murugan, B. Nandini, Halley Caixeta Oliveira, Shipra Pandey, Manickam Paulpandi, Joana Claudio Pieretti, Saroj Kumar Prasad, Amitava Rakshit, Niranjana Siddapura Ramachandrappa, Priyanka Rani, Raheela Rehman, Wallace Rosado Rolim, Amedea Barozzi Seabra, Rahat Sharif, Dhananjay Sharma, Yue Shen, S.D. Shruthi, Abijith Singh, Brajeshwar Singh, Rajesh Kumar Singh, Fabrício Nunes Tanaka, Ashutosh Tripathi, A.C. Udayashankar, Gulamnabi Vanti, Mururgan Vasanthakumaran, A.B. Vedamurthy, Lan Wang, Yan Wang, Adhemar Watanuki Filho, and Uilian Gabaldi Yonezawa

Published
2021

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