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Byline: Vidya. Mahalmani, Bikash. Medhi Introduction Space medicine may be defined as: 'The practice of all aspects of preventive medicine including screening, health-care delivery, and maintaining human performance in the [...]

Byline: Vidya. Mahalmani, Ajay. Prakash, Bikash. Medhi Preclinical research involving animals has been the gold standard for decades and is an important criterion for determining the safety and efficacy of [...]

Byline: Vidya. Mahalmani, Shweta. Sinha, Ajay. Prakash, Bikash. Medhi Drug discovery and development are lengthy and expensive process that takes nearly 10-15 years with an average amount of more than [...]

Byline: Vidya. Mahalmani, Phulen. Sarma, Ajay. Prakash, Bikash. Medhi Introduction COVID-19 is a disease caused by novel SARS-CoV-2 virus that has played a havoc worldwide. The symptoms vary largely ranging [...]

Byline: Vidya. Mahalmani, J. Kumaravel, Manav. Jain, Ajay. Prakash, Bikash. Medhi Introduction ,Coronavirus disease-2019 (COVID-19) has played a havoc that has had an enormous impact on social life, health, and [...]

Byline: Vidya. Mahalmani, T. Pugazhenthan, Niti. Mittal, Shoban. Varthya, Bikash. Medhi Introduction The COVID-19 pandemic has changed the global regulator working on approval of drugs as a fast track process [...]

Byline: Vidya. Mahalmani, Ankita. Semwal, Harpinder. Kaur, Sukhmeet. Kaur, Ajay. Prakash, Bikash. Medhi The COVID-19 pandemic, a public health emergency, has affected 29,185,976 lives worldwide and 4,846,427 people across India.[1] [...]

Byline: Vidya. Mahalmani, Dhruv. Mahendru, Ankita. Semwal, Sukhmeet. Kaur, Harpinder. Kaur, Phulen. Sarma, Ajay. Prakash, Bikash. Medhi In December 2019, severe acute respiratory syndrome-coronavirus-2, a novel coronavirus, initiated an outbreak [...]

Byline: Vidya. Mahalmani, Dhruv. Mahendru, Phulen. Sarma, Ajay. Prakash, Bikash. Medhi In December 2019, a novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak occurred in Wuhan, China, which rapidly spread [...]

Byline: Vidya. Mahalmani, Phulen. Sarma, Ajay. Prakash, Bikash. Medhi The word antibiotic means 'against life.' Antibiotics, also known as antibacterials, are medicines that help in completely killing or slowing down [...]

Objectives: The purpose of the study was to understand the perception of 2nd-year medical undergraduates regarding the implementation of competency-based medical education (CBME) in pharmacology. Materials and Methods: This cross-sectional study was undertaken by the department of pharmacology, in our institution. Out of 197 s year medical undergraduate students, 192 provided their valuable feedback. The questionnaire consisted of three types of questions: (1) multiple-choice questions, (2) rating on a 5-point Likert scale, and (3) open-ended questions. In the open-ended questions, the students were asked to share their views. Responses to the questions were recorded. Students' "feedback responses" were scrutinized in terms of percentages. Conceptual content analysis was done for open-ended questions. Results: Students were satisfied with the implementation of CBME as well as the conduct of small group teaching, self-directed learning, integrated assessment, attitude, ethics, and communication skills, and pandemic modules. They emphasized more on game-based learning and other innovative teaching-learning methods that drove their interest to understand the subject better. Conclusion: Implementation of CBME has been found to be more effective than the traditional didactic approach. [ABSTRACT FROM AUTHOR]

Glycogen synthase kinase 3 beta (GSK3 β) plays a key role in pathologic hyper phosphorylation of tau and plays an important role in the pathogenesis of Alzheimer's disease. In the present study, we have screened a set of potential hits in in silico platform to gain insight regarding binding profile with the target (GSK3 β) from molecular docking, ADME/T, and molecular dynamics (MD) simulations. The three screened compounds 6-BIBEO, 6-BIO, and SB216763 topped the docking score chart when subjected to hard scoring function extraprecision of GLIDE. The active site dynamics study through MD simulations provides insights on residues Asp133, Val135, and Ile62 which are in a state of minimum deviation from their mean special position while they interact with the respective ligands. The same molecules also displayed favorable pharmacokinetic profile, negative Ames test and falls correctly within drug-likeliness rules. These agents can be taken forward further for the development of anti-Alzheimer's drug therapy. [ABSTRACT FROM AUTHOR]