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6. The World Neurosurgery Global Champions Program: First-Year Experience of a Model Initiative for Reducing Disparities in Global Neurosurgical Literature

Author

Shlobin, Nathan A., Savage, Simon, Savage, Alexander, Torbati, Tania, Wang, Zhe, Salas-Vega, Sebastian, Mota, Marcella, Pando, Alejandro, Sheldon, Breanna, Westrup, Alison M., Ogulnick, Jonathan, Zreik, Jad, AlKahtani, Nada A.H., Jesuyajolu, Damilola, Larrey, Kasereka Kamabu, Fadalla, Tarig, Mahajan, Uma, Manijla, Nihal, Singh, Rohin, Wang, Andrew, Kanmounye, Ulrick Sidney, Moore, Christine, Benzel, Edward C., and Rosseau, Gail

Published
2023
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8. Two treatment strategies for management of Neurosymptomatic cerebrospinal fluid HIV escape in Pune, India

Author

Dravid, Ameet N, Gawali, Raviraj, Betha, Tarun P, Sharma, Avadesh K, Medisetty, Mahenderkumar, Natrajan, Kartik, Kulkarni, Milind M, Saraf, Chinmay K, Mahajan, Uma S, Kore, Sachin D, Rathod, Niranjan M, Mahajan, Umakant S, Letendre, Scott L, Wadia, Rustom S, and Calcagno, Andrea

Subjects
Clinical Research, Mental Health, Behavioral and Social Science, Infectious Diseases, HIV/AIDS, Development of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Infection, Good Health and Well Being, Adult, Anti-HIV Agents, Female, HIV Infections, Humans, India, Male, Middle Aged, Retrospective Studies, Zidovudine, Clinical Sciences, Arthritis & Rheumatology
Abstract

Symptomatic cerebrospinal fluid (CSF) viral escape (sCVE) is reported in people with HIV, who are on ritonavir-boosted protease inhibitor (PI/r) containing antiretroviral therapy (ART). Management of sCVE includes performing genotypic HIV-1 resistance testing (GRT) on CSF and plasma HIV and changing ART accordingly. Neither GRT nor newer drugs (Dolutegravir and Darunavir/ritonavir) are routinely available in India. As a result, management of sCVE includes 2 modalities: a) ART intensification by adding drugs that reach therapeutic concentrations in CSF, like Zidovudine, to existing ART or b) Changing to a regimen containing newer boosted PI/r and integrase strand transfer inhibitor (INSTI) as per GRT or expert opinion. In this retrospective study, we report the outcomes of above 2 modalities in treatment of sCVE in Pune, India.Fifty-seven episodes of sCVE in 54 people with HIV taking PI/r-containing ART were identified. Clinical, demographic, laboratory and ART data were recorded. Forty-seven cases had follow-up data available after ART change including measurement of plasma and CSF viral load (VL).Of the 47 cases, 23 received zidovudine intensification (Group A, median VL: plasma- 290, CSF- 5200 copies/mL) and 24 received PI/INSTI intensification (Group B, median VL: plasma- 265, CSF-4750 copies/mL). CSF GRT was performed in 16 participants: 8 had triple class resistance. After ART change, complete resolution of neurologic symptoms occurred in most participants (Group A: 18, Group B: 17). In Group A, follow-up plasma and CSF VL were available for 21 participants, most of whom achieved virologic suppression (VL < 20 copies/mL) in plasma (17) and CSF (15). Four participants were shifted to the PI/INSTI intensification group due to virologic failure (plasma or CSF VL > 200 copies/mL). In Group B, follow-up plasma and CSF VL were available for 23 participants, most of whom also achieved virologic suppression in plasma (21) and CSF (18). Four deaths were noted, 2 of which were in individuals who interrupted ART.This is a unique sCVE cohort that was managed with 1 of 2 approaches based on treatment history and the availability of GRT. At least 75% of participants responded to either approach with virologic suppression and improvement in symptoms.

Published
2020

14. Machine Learning Feature Selection in Archery Performance

Author

Mahajan, Uma, Krishnan, Anup, Malhotra, Vineet, Sharma, Deep, Gore, Sharad, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Merchant, S. N., editor, Warhade, Krishna, editor, and Adhikari, Debashis, editor

Published
2021
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15. Predicting Competitive Weightlifting Performance Using Regression and Tree-Based Algorithms

Author

Mahajan, Uma, Krishnan, Anup, Malhotra, Vineet, Sharma, Deep, Gore, Sharad, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Hassanien, Aboul Ella, editor, Bhatnagar, Roheet, editor, and Darwish, Ashraf, editor

Published
2021
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18. 344 The World Neurosurgery Global Champions Program: First-year Experience of a Model Initiative for Reducing Disparities in Global Neurosurgical Literature

Author

Shlobin, Nathan A., primary, Savage, Simon, additional, Savage, Alexander, additional, Torbati, Tania, additional, Wang, Zhe, additional, Salas-Vega, Sebastian, additional, Mota, Marcella, additional, Pando, Alejandro, additional, Sheldon, Breanna, additional, Westrup, Alison Megan, additional, Ogulnick, Jonathan, additional, Zreik, Jad, additional, Alkahtani, Nada Ayedh, additional, Jesuyajolu, Damilola, additional, Larrey, Kasereka Kamabu, additional, Fadalla, Tarig, additional, Mahajan, Uma V., additional, Manjila, Nihal, additional, Singh, Rohin, additional, Wang, Andrew, additional, Kanmounye, Ulrick Sidney, additional, Moore, Christine, additional, Benzel, Edward C., additional, and Rosseau, Gail Linskey, additional

Published
2024
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26. Description and assessment of a neurosurgery shadowing and research program: A paradigm for early and sustained exposure to academic neurosurgery

Author

Duy Phan Q., Negoita Serban, Mahajan Uma V., Diab Nicholas S., Agarwal Ank A., Gupte Trisha, Paranjpe Manish D., and Anderson William S.

Subjects
neurosurgery, medical education, pre-medicine, shadowing, research, surgical education, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

To describe and assess the educational value of a functional neurosurgery clinical shadowing and research tutorial for pre-medical trainees.

Published
2019
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28. Sociocultural aspects of delays in diagnosis among Tuberculosis-Diabetes Comorbid patients in Satara, India: Its implications for the implementation of the National Framework for Joint Tuberculosis-Diabetes Collaborative Activities

Author

Phutane, Mugdha Sharad, primary, Sawant, Pravin Arun, additional, Randive, Abhishek Prakash, additional, Hulsurkar, Yogita Purushottam, additional, Mahajan, Uma Satish, additional, and Kudale, Abhay Machindra, additional

Published
2023
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30. Caregivers' knowledge, perception, and management of childhood pneumonia: A study in tribal district of India.

Author

Kulkarni, Prashant, Mahajan, Uma, and Kurane, Anjali

Subjects
PNEUMONIA prevention, HEALTH literacy, LANGUAGE & languages, SELF-efficacy, SENSORY perception, PNEUMONIA in children, STATISTICAL sampling, LOGISTIC regression analysis, HAND washing, DESCRIPTIVE statistics, HELP-seeking behavior, QUANTITATIVE research, CAREGIVERS, COMMUNICATION, RESEARCH, MEDICAL screening, HEALTH education, CONFIDENCE intervals, DATA analysis software, PREVENTIVE health services
Abstract

Introduction: Childhood pneumonia, if identified early, is readily treatable through low-cost antibiotics. The study aimed to understand the family caregivers' knowledge and care-seeking behavior for the management of childhood pneumonia. The study was cross-sectional, with mixed methods assessing knowledge, perceptions, and practices of caregivers of under-five children on pneumonia using a vignette. Methodology: Systematic random sampling was used to select the participants. Of 107, more than half of the respondents were 18–25 years old. Results: Less than one-fourth were illiterate. Cough, flu, and stomach distention were the commonly reported symptoms. Food ingestion was reported as a main perceived cause; private doctors and traditional healers were the most reported source of help-seeking. Friend/family were reported as leading sources of information. Health education is to be imparted using local knowledge regarding childhood pneumonia. Traditional healers and private practitioners sensitize in early management and referral of childhood pneumonia cases. Conclusions: Information, education and communication messages need to be prepared in the local languages. Strengthening the public health sector is suggested. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Racial differences in time to blood pressure control of aneurysmal subarachnoid hemorrhage patients: A single-institution study

Author

Zhou, Xiaofei, primary, Bates, Adam Hwan, additional, Mahajan, Uma V., additional, Desai, Ansh, additional, Butke, Jeffrey, additional, Shammassian, Berje, additional, Duan, Yifei, additional, Burant, Christopher, additional, Sarna, Kaylee, additional, Sajatovic, Martha, additional, Dani, Dhimant, additional, and Hoffer, S. Alan, additional

Published
2023
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32. Impact of anemia on acute ischemic stroke outcomes: A systematic review of the literature

Author

Desai, Ansh, primary, Oh, David, additional, Rao, Elizabeth M., additional, Sahoo, Saswat, additional, Mahajan, Uma V., additional, Labak, Collin M., additional, Mauria, Rohit, additional, Shah, Varun S., additional, Nguyen, Quang, additional, Herring, Eric Z., additional, Elder, Theresa, additional, Stout, Amber, additional, and Shammassian, Berje H., additional

Published
2023
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33. Correction: Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study

Author

Mahajan, Uma V., Varma, Vijay R., Griswold, Michael E., Blackshear, Chad T., An, Yang, Oommen, Anup M., Varma, Sudhir, Troncoso, Juan C., Pletnikova, Olga, O'Brien, Richard, Hohman, Timothy J., Legido-Quigley, Cristina, and Thambisetty, Madhav

Subjects
Biological sciences
Abstract

Author(s): Uma V. Mahajan, Vijay R. Varma, Michael E. Griswold, Chad T. Blackshear, Yang An, Anup M. Oommen, Sudhir Varma, Juan C. Troncoso, Olga Pletnikova, Richard O'Brien, Timothy J. Hohman, [...]

Published
2020
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40. Inpatient virtual shared medical appointments to improve health literacy, increase patient self-efficacy, and reduce provider burnout in acute cerebrovascular pathology patients and their caregivers: a pilot study

Author

Mahajan, Uma V., primary, Sharma, Neha, additional, Maynard, Marquis, additional, Kang, Lei, additional, Labak, Collin M., additional, Raghavan, Alankrita, additional, Sajatovic, Martha, additional, Hoffer, Alan, additional, Shammassian, Berje H., additional, Wright, James M., additional, Zhou, Xiaofei, additional, and Wright, Christina Huang, additional

Published
2022
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41. Physical Activity level in doctors during Covid-19: An Online-based Cross-sectional study

Author

P, Pradeep, Sekara Guru S, Chandra, Bhartiya, Manish, Mahajan, Uma, Sharma, Deep, P, Pradeep, Sekara Guru S, Chandra, Bhartiya, Manish, Mahajan, Uma, and Sharma, Deep

Abstract

Physical activity is an important therapeutic strategy in reducing the severity of Covid-19 disease. There is a lack of studies evaluating the level of physical activity among doctors who are the frontline responders of Covid-19 pandemic. The online survey aimed at evaluating the effect factors associated with physical activity levels of doctors during Covid-19 pandemic using International Physical Activity Questionnaire Short Form (IPAQ- SF). The survey included doctors from government and private health sectors of India. Snowballing technique was used to conduct the survey. About 266 Indian doctors with a median age of 36 (IQR = 31, 46) years responded to the anonymous survey consisting of demographic details and IPAQ- SF. Median MET-minutes/week and Inter Quartile Range (IQR) were used to describe the physical activity levels of the doctors. All the data analysis was done in STATA 12.1. The total median MET-duration of doctors was 834 (IQR = 495, 1620) MET-minutes/week with 988 (IQR = 564.3, 2067.9) Kcal/week of total energy expenditure. Low, moderate and high physical activity levels of doctors were 21.4%, 54.5% and 24.1% respectively. Age, gender, doing Covid-19 duties and regular involvement in physical activity before the pandemic have significantly affected PA levels. More than 55% of doctors who reported high or moderate physical activity before the pandemic were doing significantly low physical activity during the pandemic (p < 0.0001). The Covid-19 pandemic has significantly affected the physical activity level in doctors. Doctors aged 31- 40 years performing Covid-19 duties during the conduct of the survey were likely to perform low physical activity. However, those doctors who regularly engaged in physical activity before the pandemic despite the restrictions were found to engage significantly in higher total MET-duration and expended higher energy.

Published
2022

42. Epidemiology, clinical presentation and management of COVID‐19 associated mucormycosis: A single centre experience from Pune, Western India

Author

Dravid, Ameet, primary, Kashiva, Reema, additional, Khan, Zafer, additional, Bande, Balasaheb, additional, Memon, Danish, additional, Kodre, Aparna, additional, Mane, Milind, additional, Pawar, Vishal, additional, Patil, Dattatraya, additional, Kalyani, Suraj, additional, Raut, Prathamesh, additional, Bapte, Madhura, additional, Saldanha, Charlotte, additional, Chandak, Dinesh, additional, Patil, Teerthagouda, additional, Reddy, Sateesh, additional, Bhayani, Krushnadas, additional, Suresh, Laxmi, additional, Dillibabu, Vishnu, additional, Srivastava, Shipra, additional, Khandelwal, Shubham, additional, More, Sailee, additional, Shakeel, Atif, additional, Pawar, Mohit, additional, Nande, Pranava, additional, Harshe, Amol, additional, Kadam, Sagar, additional, Hallikar, Sudhir, additional, Kamal, Nudrat, additional, Andrabi, Danish, additional, Bodhale, Sachin, additional, Raut, Akshay, additional, Chandrashekhar, Sangeeta, additional, Raman, Chandrashekhar, additional, Mahajan, Uma, additional, Joshi, Gaurav, additional, and Mane, Dilip, additional

Published
2022
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43. sj-docx-1-jpx-10.1177_23743735221106604 - Supplemental material for Use of Patients’ Protected Health Information to Solicit Hospital Funds: How did This Practice Come About?

Author

Mahajan, Uma V, Wafapoor, Vahid, Mahajan, Omkar A, and Anderson, William S

Subjects
111708 Health and Community Services, Medicine, FOS: Health sciences
Abstract

Supplemental material, sj-docx-1-jpx-10.1177_23743735221106604 for Use of Patients’ Protected Health Information to Solicit Hospital Funds: How did This Practice Come About? by Uma V Mahajan, Vahid Wafapoor, Omkar A Mahajan and William S Anderson in Journal of Patient Experience

Published
2022
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46. Combination therapy of Tocilizumab and steroid for management of COVID-19 associated cytokine release syndrome

Author

Dravid, Ameet, Kashiva, Reema, Khan, Zafer, Memon, Danish, Kodre, Aparna, Potdar, Prashant, Mane, Milind, Borse, Rakesh, Pawar, Vishal, Patil, Dattatraya, Banerjee, Debashis, Bhoite, Kailas, Pharande, Reshma, Kalyani, Suraj, Raut, Prathamesh, Bapte, Madhura, Mehta, Anshul, Reddy, M. Sateesh, Bhayani, Krushnadas, Laxmi, S. S., Vishnu, P. D., Srivastava, Shipra, Khandelwal, Shubham, More, Sailee, Shinde, Rohit, Pawar, Mohit, Harshe, Amol, Kadam, Sagar, Mahajan, Uma, Joshi, Gaurav, and Mane, Dilip

Subjects
infectious complications, Observational Study, COVID-19, cytokine release syndrome, mechanical ventilation, Tocilizumab, Research Article, intensive care, steroids
Abstract

Cytokine release syndrome (CRS) or cytokine storm is thought to be the cause of inflammatory lung damage, worsening pneumonia and death in patients with COVID-19. Steroids (Methylprednislone or Dexamethasone) and Tocilizumab (TCZ), an interleukin-6 receptor antagonist, are approved for treatment of CRS in India. The aim of this study was to evaluate the efficacy and safety of combination therapy of TCZ and steroid in COVID-19 associated CRS. This retrospective cohort study was conducted at Noble hospital and Research Centre (NHRC), Pune, India between April 2 and November 2, 2020. All patients administered TCZ and steroids during this period were included. The primary endpoint was incidence of all cause mortality. Secondary outcomes studied were need for mechanical ventilation and incidence of systemic and infectious complications. Baseline and time dependent risk factors significantly associated with death were identified by Relative risk estimation. Out of 2831 admitted patients, 515 (24.3% females) were administered TCZ and steroids. There were 135 deaths (26.2%), while 380 patients (73.8%) had clinical improvement. Mechanical ventilation was required in 242 (47%) patients. Of these, 44.2% (107/242) recovered and were weaned off the ventilator. Thirty seven percent patients were managed in wards and did not need intensive care unit (ICU) admission. Infectious complications like hospital acquired pneumonia, blood stream bacterial and fungal infections were observed in 2.13%, 2.13% and 0.06% patients respectively. Age ≥ 60 years (P = .014), presence of co-morbidities like hypertension (P = .011), IL-6 ≥ 100 pg/ml (P = .002), D-dimer ≥ 1000 ng/ml (P

Published
2021

47. Bilateral Deep Brain Stimulation is the Procedure to Beat for Advanced Parkinson Disease: A Meta-Analytic, Cost-Effective Threshold Analysis for Focused Ultrasound

Author

Mahajan, Uma V, primary, Ravikumar, Vinod K, additional, Kumar, Kevin K, additional, Ku, Seul, additional, Ojukwu, Disep I, additional, Kilbane, Camilla, additional, Ghanouni, Pejman, additional, Rosenow, Joshua M, additional, Stein, Sherman C, additional, and Halpern, Casey H, additional

Published
2021
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49. Epidemiology, clinical presentation and management of COVID-19 associated Mucormycosis: A single center experience from Pune, Western India.

Author

Dravid, Ameet, primary, Kashiva, Reema, additional, Khan, Zafer, additional, Bande, Balasaheb, additional, Memon, Danish, additional, Kodre, Aparna, additional, Potdar, Prashant, additional, Mane, Milind, additional, Tamboli, Asir, additional, Pawar, Vishal, additional, Patil, Dattatraya, additional, Banerjee, Debashis, additional, Bhoite, Kailas, additional, Shinde, Akshay, additional, Pharande, Reshma, additional, Kalyani, Suraj, additional, Raut, Prathamesh, additional, Bapte, Madhura, additional, Saldanha, Charlotte, additional, Chandak, Dinesh, additional, Ajani, Fouzia, additional, Mehta, Anshul, additional, Reddy, M Sateesh, additional, Bhayani, Krushnadas, additional, S S, Laxmi, additional, P D, Vishnu, additional, Srivastava, Shipra, additional, Khandelwal, Shubham, additional, More, Sailee, additional, Shakeel, Atif, additional, Pawar, Mohit, additional, Nande, Pranava, additional, Harshe, Amol, additional, Kadam, Sagar, additional, Halikar, Sudhir, additional, Kamal, Nudrat, additional, Andrabi, Danish, additional, Bodhale, Sachin, additional, Raut, Akshay, additional, Gawande, Pushkar, additional, Bhandari, Ankush, additional, Wasmatkar, Nilesh, additional, Sarkar, Adnanali, additional, Chandrashekhar, Sangeeta, additional, Butiyani, Pallavi, additional, Akhade, Geetanjali, additional, Abnave, Aditi, additional, Raman, Chandrashekhar, additional, Basade, Siraj, additional, Mahajan, Uma, additional, Joshi, Gaurav, additional, and Mane, Dileep, additional

Published
2021
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