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Sleep plays a complex bidirectional role in the life span of most mental health illness. How soon poor sleep becomes an indicator of future mental illness is unknown. Infant sleep is a complex concept which can impact greatly on both baby and family well-being. Thus, a systematic review and meta-analysis were conducted to investigate whether poor infant sleep to age two is associated with future mental health symptoms. A systematic search of Medline, Embase, CINAHL, PsycINFO, Web of Science and Cochrane was conducted, using PRISMA guidelines. The search resulted in 17 articles to include in this review. A combined adjusted odds ratios of 1.65 (95% CI = 1.34, 2.05) for infant sleep problems leading to subsequent mental health symptoms resulted. A variety of outcome measures for both poor infant sleep and mental health symptoms/diagnosis were used, limiting the generalisability of results. Poor sleep in infancy should be considered one of many risk factors for future mental health disorder signifying the importance of early intervention. [ABSTRACT FROM AUTHOR]