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The large amount of excess adipose tissue affects negatively every single step of the assisted reproductive treatment process – from the controlled ovarian hyperstimulation (COH) to obstetric complications and health consequences for the fetus. A number of scientific data show correlation between impaired clinical pregnancy rates (CPR) and obese patients maintaining high body mass index (BMI). The debate whether high proportion of body fat negatively affects oocyte quality or only impacts endometrial receptivity remains open.

Pelvic exenteration (PE) is an operative method for one-moment removal of pelvic organs, including reproductive tract, bladder, and rectosidgmoid. It is most commonly indicated in gynecologic oncology for treatment of locally advanced cancer or recurrence with central localization. The purpose of this study was to evaluate survival rate and complications in different types of PEs performed for cervical, uterine, and ovarian cancer and to report the authors' experience. Patients undergoing PE for cervical, uterine, and ovarian cancer (n=46) were prospectively collected. Operative techniques types included total PE (n=9), anterior PE (n=14), posterior PE (n=7), and modified posterior PE (n=16). Overall intra- and postoperative complication rate was 34.8% for the series. Mild complications occurred in 28.2% and severe complications in 6.5%. Perioperative mortality was 2.2%. PE in patients with advanced stage of gynecological malignancies was associated with high complication rate and high perioperative mortality and morbidity. Therefore, operative techniques with proven safety should be used. Creating ureter anastomosis with incontinent urinary conduit from terminal ileum can be considered as such technique. Although all factors that impact negative on quality of life, PE remains an alternative for extending life of these types of patients. [ABSTRACT FROM AUTHOR]

Background: Fertilization check performed at the 18th hour following classic in vitro fertilization procedure (IVF) or intracytoplasmic sperm injection (ICSI) is a critical stage in assisted reproduction. The success of the treatment is significantly reliant on the quantity of zygotes exhibiting two pronuclei. Consequently, low fertilization rates or complete fertilization failure are highly undesirable outcomes for both patients and reproductive specialists. Applying additional calcium ionophore for oocyte activation subsequent to ICSI may offer benefits and potentially enhance treatment outcomes, particularly for patients who have experienced low or absent fertilization rates (FR) in previous treatment cycles. The aim of the study is to evaluate the efficacy of Ca2+ ionophore application for oocyte activation., Methods: A retrospective analysis of 924 oocytes obtained from 120 patients who underwent ICSI cycles with a history of low or no fertilization as a result of previous unsuccessful treatment rounds. The next ART cycle followed with additional oocyte Ca2+ ionophore activation applied in 57 of the cases in order to optimize the treatment process (Group 1), and 63 patients were included and their outcomes followed as a control group (Group 2).We conducted a comparative analysis of results in both groups. The study's primary outcomes encompassed fertilization, cleavage embryo quality, blastocyst rate, and established clinical pregnancies., Results: At day 1 fertilization check we had 274/386 zygotes (71%FR) in group 1 and 132/410 in group 2 (32.2%FR), (P < 0.0001). Twenty-two (34.9%) cycles in group 2 resulted in total fertilization failure (TFF). At the cleavage stage top-quality embryos from group 1 were significantly higher (P = 0.0021) in comparison to group 2. Forty-eight embryo transfers (ET) were performed in group 1 resulting in 41.67% clinical pregnancies versus 33 ET and only 4 pregnancies (12.12%) for group 2 (P = 0.0044)., Conclusions: The results confirm the appropriateness of assisted oocyte activation as an additional method in cases of previous fertilization failure cycles.

Introduction: Various factors related to an " in vitro " fertilization (IVF) procedure may influence the rate of small for gestational age (SGA) newborns in such pregnancies., Aim: The aim of the study was to determine neonatal SGA incidence in singleton IVF pregnancies compared to spontaneous ones., Materials and Methods: We conducted both a prospective and a retrospective study within the period of January 2013-December 2017, which included 336 patients with a singleton IVF pregnancy at the time of delivery - the study group (SG), and 493 women with a spontaneous conception - the control group (CG)., Results: Neonatal SGA rate was significantly higher in the SG as compared to the CG, p  < .05, as well as in case of multiple embryotransfer (ET), vanishing twin syndrome (VTS), fresh ET against frozen embryotransfer (FET), female infertility factor., Conclusion: Singleton pregnancies after an IVF technique show a higher neonatal SGA rate compared to spontaneous ones.

Leiomyomas of the Fallopian tubes are rare and their correct diagnosis is extremely difficult. Usually they are incidental findings seen at autopsy or unrelated surgical procedures: A 34-year-old woman presented with lower abdominal pain. Transvaginal ultrasound revealed a solid 7 cm extrauterine mass. Both ovaries are normal. Our preoperative diagnosis was torsion of the fallopian tube due intratubal leiomyoma. Laparoscopic surgery was performed and the leiomyoma was found to have originated from the isthmus of the right Fallopian tube. Laparoscopic myomectomy was performed with preservation of the ramus tubarius dextra. The histological examination concluded to a leiomyoma with ischemic changes. We report a case of torsion of a tubal leiomyoma, which was successfully managed laparoscopically.

Lymphadenectomy has traditionally been performed using large incisions during laparotomy. Since the initial report by Dargent and colleagues in the late 1980s, laparoscopic lymphadenectomy has been utilized in the management of gynecologic malignancies. After Dargent's description of the first pelvic lymphadenectomy performed laparoscopically, Nezhat et al. described the first para-aortic lymphadenectomy performed laparoscopically forcancer of the uterine cervix. Many raports since have described the safety and effectiveness of laparoscopic lymphadenectomy for gynecologic malignancies.

Genuine urinary stress incontinence (GUSI) is defined by the International Continence Society (ICS) as involuntary loss of urine coincident with increased intra-abdominal pressure in the absence of a detrusor contraction or an over-distended bladder. If the patient demonstrates a cystocele secondary to a paravaginal defect, a paravaginal defect repair should be performed before the colposuspension. The laparoscopic retropubic colposuspension gained popularity because of its reported advantages of improved visualization, shorter hospital stay, faster recovery and decreased blood loss. A review of our experience revealed 11 of 24 patients had a Burch urethropexy and paravaginal repair and 13 of 24 a Burch urethropexy alone. Average operative time was 80 min, estimated blood loss of less than 50 ml and hospital stays less than 48 h.

Laparoscopic myomectomy and total laparoscopic hysterectomy are challenging surgical procedures for gynecologists, which can result in great blood loss. Most of the conversions to laparotomy happened because of intraoperative bleeding. Blocking uterine perfusion during,, Class II" laparoscopic procedures is valuable and feasible for the management of our patients. We present our modification of uterine artery identification and clipping.

Uterine myoma is the most common benign uterine tumor in women of reproductive age and occurs in 20-25 % of the worldwide population. Heavy menstrual bleeding, pelvic pressure and pain and reproductive disfunction are common symptoms that impair women's health and quality of live. No currently approved medical treatment is able to completely eliminate fibroids. Until recently, gonadotropin-releasing hormone agonist were the only available drugs for preoperative treatment of fibroids. Since February 2012, ulipristal acetate (UPA) is also approved in Europe for preoperative fibroid treatment. One-third from them need adjuvant surgical treatment.

Transvaginallaparoscopy (TVL) has been described by S. Gords in 1990's. Comparig to histerosaqlpingograpy (HSG) it allows visualization of tubal mucosa. Transvaginal laparoscopy is alternative of conventional laparoscopy for infertility patients. It has significant advantage regarding minimal invasiveness and absence of abdominal incisions. Literature data shows 96.1% accuracy of TVL against laparoscopy regarding operative findings. Presence of operative port ensures possibility of doing minimal interventions like adhesiolysis, ovarian drilling and endometrioma ablation. Although these advantages this procedure is not very popular in our country yet.

Uterine myoma is the most frequent benign tumor of female organs. Intraligamentary myomas in the broad ligament are rare. We present a case of 50 years old patient with 22 cm intraligamentary myoma with cystic degeneration, who is referred to the Gynecological Department of Ob/Gyn Hospital "Dr. Shterev" with complains of severe pain. This case is interesting for its rareness and diagnostic dilemma, because degenerative myomas can imitate malignant mass. Total laparoscopic hysterectomy with ablastic vaginal morcellation of the specimen in endobag was performed. The patient was discharged from the clinic next day.

A great number operative techniques for correction of retroverted uterus are reported in the last years. The aim of these different methods is correction of the retroversion of the uterus, which is connected with pelvic congestion and symptomatic relief. We present a clinical case of 26 years old patient with one Caesarean section. The lady complains of chronic pelvic pain, dispareunia and dismenorrhea. The US exam shows an uterus in strong retroversion position. We restored the anatomic position of the uterus using laparoscopic anterior ligementopexy.

Uterine leiomyomas are one of the most common benign smooth muscle tumors in women, with a prevalence of 20 to 40% in women over the age of 35 years. Fifty percent of them may necessitate treatment, because of bleeding, pelvic pain and infertility. Laparoscopic myomectomy is one of the treatment options. The major concern of myomectomy either by open procedure or by laparoscopy is the bleeding encountered during the operation. One of the methods to reduce the intraoperative blood loss and to prevent excessive bleeding is the clipping of both uterine arteries and aa. ovaricae.

Pelvic exenteration is an operative method for one-moment removal of pelvic organs, including reproductive tract, bladder and rectosidgmoid. It most common indicated in gynecologic oncology for treatment of locally advanced cancer or recidive with central location. Pelvic exenteration can be used for healing of patients with genital cancer. Frequency of serious complications can reach 50%, that emphasizes the need of careful discuss of risks and benefits with the patients who are indicated for that kind of operation. For the period 2004-2012 common 46 exenterations are performed at FSHOG "St. Sofia", form which 9 are total (TE), 14 anterior (AE), 7 posterior (PE), 16 modified posterior exenterations (MPE). Average operative time is 459 min (237-620 min), depending on the type of operation. Average blood loss is 1200 ml (800-2500 ml). Report of the complications shows that eight patients have had 1-st degree complication.

Numerous surgical procedures have been described for the management of pelvic organ prolapse. Laparoscopic sacrocolpopexy has evolved from classical abdominal sacrocolpopexy and provides the potential to combine the success rate of an abdominal approach with faster recovery time associated with a minimally invasive technique. Pelvic organ support was assessed objectively using the pelvic organ prolapse quantification scale (POP-Q). Tissue dissection and mesh placement are facilitated by magnification of the operating field using laparoscopic approach. Our results confirm previous findings that laparoscopic sacrocolpopexy is a safe and efficacious surgical treatment for pelvic organ prolapse. It provides excellent support and good functional outcome with overall improvement in sexual function.

The aim of this study is to determine the most appropriate method for operative treatment of uterine myoma through comparison of laparoscopic myomectomy (LM) and abdominal myomectomy (AM). We will examine perioperative indicators and results for patients with uterine myomas. We operated 172 women for the period from January 2011 to April 2014. 106 patients were operated by abdominal myomectomy and 66 were operated by laparoscopic myomectomy. In this study were included only cases with intramural fibroids bigger than 5 cm. We explored the following indicators: age, BMI, preoperative Hgb, preoperative Hct, size, number and location of the myomas for both groups. We analyzed intra- and postoperative indicators operating time, hospital stay, postoperative Hgb and Hct. Data shows less postoperative decrease of Hgb and Hct, less blood loss, shorter hospital stay for the group with laparoscopic myomectomy, but significantly increased operative time compared to the group with abdominal myomectomy.

Objective: To investigate the risk of adhesions after laparoscopic myomectomy (LM). To establish the percentage of adhesions, their kind, situation and magnitude., Materials and Methods: For the period form June 2011 to November 2013 totally 81 patients were operated by LM. In the study only patients with intramural leymyomas bigger than 5 sm were included. For this period 14 patients had second-look because of the need of another operation--LS or Ceasarean section. 22 myoma incisions were checked. We established 35.7% adhesions per patient. After LM adnexas were engaged in 14.2%., Conclusion: The factors, responsible for the formation of postoperative adhesions are: the location of the myoma in the posterior uterine wall, excessive accumulation of suturing materials and additional operative interventions. For patients underwent LM and willing pregnancy we recommend second look laparoscopy.

Bidirectional barbed suture introduces a new paradigm in laparoscopic suturing. The aim of our study is to evaluate the efficacy and safety of using bidirectional barbed suture in laparoscopic myomectomy. It included 102 women, requiring a laparoscopic myomectomy for symptomatic uterine fibroids from June 2011 to May 2014. They are divided into two groups according to the thread used for closing the uterine incision. We used bidirectional barbed suture Quill and Vicryl in the control group. The mean operative time was shorter in the Quill group than in control group. Both intraoperative blood loss and drop of hemoglobin were significantly lower in the Quill group. The use of bidirectional barbed suture appears to be safe for closing the hysterotomy site during a laparoscopic myomectomy.

Laparoscopic gynecologic procedures have become increasingly popular but their widespread use has been limited by training issues. Recent technological advancements have led to the introduction of new three-dimensional (3D) cameras in laparoscopic surgery. The use of 3-dimensional (3 D) vision may aid in training and performance of laparoscopic tasks. 3-D visualization improves the learning curve forlaparoscopic surgery. Surgeons must consider 3D systems when leaming complex laparoscopic surgeries.

Laparoscopic myomectomy (LM) has been an alternative to abdominal myomectomy in cases of subserosal and intramural myomas since 1990. In the literature less attention is paid to the factors responsible for the length of the surgical time of the LM. Our study comprehends 66 patients underwent laparoscopic myomectomy for one or more intramural myomas with size > 5 sm. In order to evaluate the factors that are responsible for the duration of the procedure we survey the following indicators: age, BMI, year of the operation, previous abdominal operations, way of delivery, size, number and localization of the myomas. Our results show that statistically significant effect for the duration of LM have the yearof the operation, numberof the myomas and their localization in the uterine wall. Significantly longer operative time is detected in 2012 (133.57 +/- 17,805 min.) and the shorter time was in 2014 (66.67 +/- 20, 237 min.) (P < 0.05). We established statistically significant relation between the number of the myomas and duration of the operation (P=0.023). The analysis of the indicator localization of the myomas shows that myomas in the anterior uterine wall are with shortest average surgical time--90.5 +/- 33, 321 min., next are these in the posterior uterine wall--93.81+/- 39, 176 min. Myomas in the fundus of the uterus have longest average surgical time--115.83 +/- 35, 253 min.