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187 results on '"Maguire, David R."'

8. Behavioral Pharmacology of Drugs Acting at Mu Opioid Receptors

Author

Gerak, Lisa R., Maguire, David R., France, Charles P., Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Nader, Michael A., editor, and Hurd, Yasmin L., editor

Published
2020
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30. Developing Improved Translational Models of Pain: A Role for the Behavioral Scientist

Author

Withey, Sarah L., Maguire, David R., and Kangas, Brian D.

Abstract

The effective management of pain is a longstanding public health concern. Although opioids have been frontline analgesics for decades, they also have well-known undesirable effects that limit their clinical utility, such as abuse liability and respiratory depression. The failure to develop better analgesics has, in some ways, contributed to the escalating opioid epidemic that has claimed tens of thousands of lives and has cost hundreds of billions of dollars in health-care expenses. A paradigm shift is needed in the pharmacotherapy of pain management that will require extensive efforts throughout biomedical science. The purpose of the present review is to highlight the critical role of the behavioral scientistto devise improved translational models of pain for drug development. Despite high heterogeneity of painful conditions that involve cortical-dependent pain processing, current models often feature an overreliance on simple reflex-based measures and an emphasis on the absence, rather than presence, of behavior as evidence of analgesic efficacy. Novel approaches should focus on the restoration of operant and other CNS-mediated behavior under painful conditions.

Published
2024
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45. Countermeasures for Preventing and Treating Opioid Overdose

Author

France, Charles P., primary, Ahern, Gerard P., additional, Averick, Saadyah, additional, Disney, Alex, additional, Enright, Heather A., additional, Esmaeli‐Azad, Babak, additional, Federico, Arianna, additional, Gerak, Lisa R., additional, Husbands, Stephen M., additional, Kolber, Benedict, additional, Lau, Edmond Y., additional, Lao, Victoria, additional, Maguire, David R., additional, Malfatti, Michael A., additional, Martinez, Girardo, additional, Mayer, Brian P., additional, Pravetoni, Marco, additional, Sahibzada, Niaz, additional, Skolnick, Phil, additional, Snyder, Evan Y., additional, Tomycz, Nestor, additional, Valdez, Carlos A., additional, and Zapf, Jim, additional

Published
2020
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