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2. The prescriber's guide to classic MAO-inhibitors (phenelzine, tranylcypromine, isocarboxazid) for treatment-resistant depression

Author

Van Den Eynde, Vincent, Abdelmoemin, Wegdan R., Abraham, Magid M., Amsterdam, Jay D., Anderson, Ian M., Andrade, Chittaranjan, Baker, Glen B., Beekman, Aartjan T.F., Berk, Michael, Birkenhäger, Tom K., Blackwell, Barry B., Blier, Pierre, Blom, Marc B.J., Bodkin, J. Alexander, Cattaneo, Carlo Ignazio, Dantz, Bezalel, Davidson, Jonathan, Dunlop, Boadie W., Estévez, Ryan F., Feinberg, S. Shalom, Finberg, John P.M., Fochtmann, Laura J., Gotlib, David, Holt, Andrew, Insel, Thomas R., Larsen, Jens Knud, Mago, Rajnish, Menkes, David B., Meyer, Jonathan M., Nutt, David J., Parker, Gordon, Rego, Mark D., Richelson, Elliott, Ruhé, Henricus G., Sáiz-Ruiz, Jerónimo, Stahl, Stephen M., Steele, Thomas, Thase, Michael E., Ulrich, Sven, Van Balkom, Anton J.L.M., Vieta, Eduard, Whyte, Ian, Young, Allan H., Gillman, Peter Kenneth, Van Den Eynde, Vincent, Abdelmoemin, Wegdan R., Abraham, Magid M., Amsterdam, Jay D., Anderson, Ian M., Andrade, Chittaranjan, Baker, Glen B., Beekman, Aartjan T.F., Berk, Michael, Birkenhäger, Tom K., Blackwell, Barry B., Blier, Pierre, Blom, Marc B.J., Bodkin, J. Alexander, Cattaneo, Carlo Ignazio, Dantz, Bezalel, Davidson, Jonathan, Dunlop, Boadie W., Estévez, Ryan F., Feinberg, S. Shalom, Finberg, John P.M., Fochtmann, Laura J., Gotlib, David, Holt, Andrew, Insel, Thomas R., Larsen, Jens Knud, Mago, Rajnish, Menkes, David B., Meyer, Jonathan M., Nutt, David J., Parker, Gordon, Rego, Mark D., Richelson, Elliott, Ruhé, Henricus G., Sáiz-Ruiz, Jerónimo, Stahl, Stephen M., Steele, Thomas, Thase, Michael E., Ulrich, Sven, Van Balkom, Anton J.L.M., Vieta, Eduard, Whyte, Ian, Young, Allan H., and Gillman, Peter Kenneth

Abstract

This article is a clinical guide which discusses the state-of-the-art usage of the classic monoamine oxidase inhibitor (MAOI) antidepressants (phenelzine, tranylcypromine, and isocarboxazid) in modern psychiatric practice. The guide is for all clinicians, including those who may not be experienced MAOI prescribers. It discusses indications, drug-drug interactions, side-effect management, and the safety of various augmentation strategies. There is a clear and broad consensus (more than 70 international expert endorsers), based on 6 decades of experience, for the recommendations herein exposited. They are based on empirical evidence and expert opinion - this guide is presented as a new specialist-consensus standard. The guide provides practical clinical advice, and is the basis for the rational use of these drugs, particularly because it improves and updates knowledge, and corrects the various misconceptions that have hitherto been prominent in the literature, partly due to insufficient knowledge of pharmacology. The guide suggests that MAOIs should always be considered in cases of treatment-resistant depression (including those melancholic in nature), and prior to electroconvulsive therapy - while taking into account of patient preference. In selected cases, they may be considered earlier in the treatment algorithm than has previously been customary, and should not be regarded as drugs of last resort; they may prove decisively effective when many other treatments have failed. The guide clarifies key points on the concomitant use of incorrectly proscribed drugs such as methylphenidate and some tricyclic antidepressants. It also illustrates the straightforward bridging methods that may be used to transition simply and safely from other antidepressants to MAOIs.

Published
2023

6. The prescriber’s guide to classic MAO inhibitors (phenelzine, tranylcypromine, isocarboxazid) for treatment-resistant depression

Author

Van den Eynde, Vincent, primary, Abdelmoemin, Wegdan R., additional, Abraham, Magid M., additional, Amsterdam, Jay D., additional, Anderson, Ian M., additional, Andrade, Chittaranjan, additional, Baker, Glen B., additional, Beekman, Aartjan T.F., additional, Berk, Michael, additional, Birkenhäger, Tom K., additional, Blackwell, Barry B., additional, Blier, Pierre, additional, Blom, Marc B.J., additional, Bodkin, Alexander J., additional, Cattaneo, Carlo I., additional, Dantz, Bezalel, additional, Davidson, Jonathan, additional, Dunlop, Boadie W., additional, Estévez, Ryan F., additional, Feinberg, Shalom S., additional, Finberg, John P.M., additional, Fochtmann, Laura J., additional, Gotlib, David, additional, Holt, Andrew, additional, Insel, Thomas R., additional, Larsen, Jens K., additional, Mago, Rajnish, additional, Menkes, David B., additional, Meyer, Jonathan M., additional, Nutt, David J., additional, Parker, Gordon, additional, Rego, Mark D., additional, Richelson, Elliott, additional, Ruhé, Henricus G., additional, Sáiz-Ruiz, Jerónimo, additional, Stahl, Stephen M., additional, Steele, Thomas, additional, Thase, Michael E., additional, Ulrich, Sven, additional, van Balkom, Anton J.L.M., additional, Vieta, Eduard, additional, Whyte, Ian, additional, Young, Allan H., additional, and Gillman, Peter K., additional

Published
2022
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29. Lamotrigine for major depressive disorder is inappropriate

Author

Mago, Rajnish

Subjects
Major depressive disorder -- Drug therapy, Lamotrigine -- Usage -- Health aspects, Health, Psychology and mental health
Abstract

Lamotrigine is an important medication option for the treatment of bipolar disorders. However, many clinicians also use it in patients with a (unipolar) depressive disorder who have not responded adequately [...]

Published
2013

32. Antidepressants and persistent pulmonary hypertension of the newborn

Author

Mago, Rajnish

Subjects
United States. Food and Drug Administration, Serotonin uptake inhibitors, Pulmonary hypertension, Infants (Newborn), Health, Psychology and mental health
Abstract

A landmark paper published in 2006 reported that the use of SSRIs after the 20th week of pregnancy is associated with an elevated risk of a rare but serious abnormality--persistent [...]

Published
2012

33. Bupropion after nonresponse or partial response to an SSRI or SNRI?

Author

Mago, Rajnish

Subjects
Antidepressants -- Surveys, Serotonin uptake inhibitors -- Surveys, Bupropion -- Surveys, Health, Psychology and mental health
Abstract

This is the third in a series of occasional columns that aim to help clinicians interpret research related to a clinical question. Perhaps more important, the tips and discussion of [...]

Published
2012

34. Efficacy of drugs in bipolar depression: what the data show

Author

Mago, Rajnish

Subjects
Bipolar disorder -- Drug therapy, Health, Psychology and mental health
Abstract

This is the second installment of a new series in which clinically relevant research is briefly discussed and, perhaps more important, a few tips on how to read and interpret [...]

Published
2010

35. Practical implications of a study on treating chronic insomnia

Author

Mago, Rajnish

Subjects
Cognitive therapy -- Health aspects -- Research, Insomnia -- Care and treatment -- Research, Health, Psychology and mental health, Care and treatment, Research, Health aspects
Abstract

More than a thousand articles on mental disorders are published in medical journals each month! Also, clinicians have limited training, time, and inclination to keep up with reading research articles [...]

Published
2009

36. Coffee, Cigarettes and Meds: What Are the Metabolic Effects?

Author

Pinninti, Narsimha R., Mago, Rajnish, and Leon, Jose de

Subjects
Caffeine -- Risk factors, Smoking -- Risk factors -- Care and treatment, Mental illness -- Risk factors -- Care and treatment
Abstract

The prevalence of smoking in severe mental disorders is higher than the normal population. In worldwide schizo-phrenia studies, the rate is approximately six times higher than in the general population [...]

Published
2005

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