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7 results on '"Magnuson, J.K."'

2. Genomic sequence of the wood–rotting Schizophyllum commune strain H4–8: the model organism to study mushroom formation

Author

Ohm, R.A., de Jong, J.F., Lugones, L.G., Aerts, A., Kothe, E., De Vries, R.P., Record, E., Baker, S.E., Bartholomew, K.A., Coutinho, P.M., Erdmann, S., Fowler, T.J., Gathman, A.C., Henrissat, B., Knabe, N.., Kües, U., Levasseur, A., Lilly, W.W., Lindquist, E., Lucas, S., Magnuson, J.K., Piumi, F., Raudaskoski, M., Salamov, A., Schmutz, F., Schwarze, F.W.M.R., Stajich, J., van Kuyk, P.A., Horton, J.S., Grigoriev, I.V., and Wösten, H.A.B.

Published
2010

3. Fungal genomics: Organic acid production and secondary metabolism

Author

Baker S.E., Culley D., Magnuson J.K., Perrone G., Gallo A., Mulè G., Susca A., and Logrieco A.

Subjects
food and beverages
Abstract

Fungi of the genus Aspergillus are well known as producers of both organic acids and polyketides. Aspergillus carbonarius is closely related to Aspergillus niger, an important model organism as well as an industrial enzyme and citric acid producer. Aspergillus carbonarius is also an economically significant organism as the main agent of ochratoxin A contamination of wine. We have characterized the putative ochratoxin A biosynthetic cluster and have initiated manual annotation of the draft genome sequence. While A. niger has been recently shown to produce fumonisin B2, the biosynthetic cluster for fumonisin biosynthesis is absent from the A. carbonarius genome. We have also examined ESTs from A. terreus, a producer of itaconic acid. Analysis of the ESTs has led to the discovery a gene cluster involved in itaconic acid production.

Published
2009

4. Comparative genomics of Ceriporiopsis subvermispora and Phanerochaete chrysosporium provide insight into selective ligninolysis

Author

Fernandez-Fueyo, E., Ruiz-Duenas, F.J., Ferreira, P., Floudas, D., Hibbett, D.S., Canessa, P., Larrondo, L.F., James, T.Y., Seelenfreund, D., Lobos, S., Polanco, R., Tello, M., Honda, Y., Watanabe, T., Ryu, J.S., Kubicek, C.P., Schmoll, M., Gaskell, J., Hammel, K.E., St John, F.J., Vanden Wymelenberg, A., Sabat, G., Splinter BonDurant, S., Syed, K., Yadav, J.S., Doddapaneni, H., Subramanian, V., Lavin, J.L., Oguiza, J.A., Perez, G., Pisabarro, A.G., Ramirez, L., Santoyo, F., Master, E., Coutinho, P.M., Henrissat, B., Lombard, V., Magnuson, J.K., Kues, U., Hori, C., Igarashi, K., Samejima, M., Held, B.W., Barry, K.W., LaButti, K.M., Lapidus, A., Lindquist, E.A., Lucas, S.M., Riley, R., Salamov, A.A., Hoffmeister, D., Schwenk, D., Hadar, Y., Yarden, O., de Vries, R.P., Wiebenga, A., Stenlid, J., Eastwood, D., Grigoriev, I.V., Berka, R.M., Blanchette, R.A., Kersten, P., Martinez, A.T., Vicuna, R., Cullen, D., Fernandez-Fueyo, E., Ruiz-Duenas, F.J., Ferreira, P., Floudas, D., Hibbett, D.S., Canessa, P., Larrondo, L.F., James, T.Y., Seelenfreund, D., Lobos, S., Polanco, R., Tello, M., Honda, Y., Watanabe, T., Ryu, J.S., Kubicek, C.P., Schmoll, M., Gaskell, J., Hammel, K.E., St John, F.J., Vanden Wymelenberg, A., Sabat, G., Splinter BonDurant, S., Syed, K., Yadav, J.S., Doddapaneni, H., Subramanian, V., Lavin, J.L., Oguiza, J.A., Perez, G., Pisabarro, A.G., Ramirez, L., Santoyo, F., Master, E., Coutinho, P.M., Henrissat, B., Lombard, V., Magnuson, J.K., Kues, U., Hori, C., Igarashi, K., Samejima, M., Held, B.W., Barry, K.W., LaButti, K.M., Lapidus, A., Lindquist, E.A., Lucas, S.M., Riley, R., Salamov, A.A., Hoffmeister, D., Schwenk, D., Hadar, Y., Yarden, O., de Vries, R.P., Wiebenga, A., Stenlid, J., Eastwood, D., Grigoriev, I.V., Berka, R.M., Blanchette, R.A., Kersten, P., Martinez, A.T., Vicuna, R., and Cullen, D.

Abstract

Efficient lignin depolymerization is unique to the wood decay basidiomycetes, collectively referred to as white rot fungi. Phanerochaete chrysosporium simultaneously degrades lignin and cellulose, whereas the closely related species, Ceriporiopsis subvermispora, also depolymerizes lignin but may do so with relatively little cellulose degradation. To investigate the basis for selective ligninolysis, we conducted comparative genome analysis of C. subvermispora and P. chrysosporium. Genes encoding manganese peroxidase numbered 13 and five in C. subvermispora and P. chrysosporium, respectively. In addition, the C. subvermispora genome contains at least seven genes predicted to encode laccases, whereas the P. chrysosporium genome contains none. We also observed expansion of the number of C. subvermispora desaturase-encoding genes putatively involved in lipid metabolism. Microarray-based transcriptome analysis showed substantial up-regulation of several desaturase and MnP genes in wood-containing medium. MS identified MnP proteins in C. subvermispora culture filtrates, but none in P. chrysosporium cultures. These results support the importance of MnP and a lignin degradation mechanism whereby cleavage of the dominant nonphenolic structures is mediated by lipid peroxidation products. Two C. subvermispora genes were predicted to encode peroxidases structurally similar to P. chrysosporium lignin peroxidase and, following heterologous expression in Escherichia coli, the enzymes were shown to oxidize high redox potential substrates, but not Mn2+. Apart from oxidative lignin degradation, we also examined cellulolytic and hemicellulolytic systems in both fungi. In summary, the C. subvermispora genetic inventory and expression patterns exhibit increased oxidoreductase potential and diminished cellulolytic capability relative to P. chrysosporium., Efficient lignin depolymerization is unique to the wood decay basidiomycetes, collectively referred to as white rot fungi. Phanerochaete chrysosporium simultaneously degrades lignin and cellulose, whereas the closely related species, Ceriporiopsis subvermispora, also depolymerizes lignin but may do so with relatively little cellulose degradation. To investigate the basis for selective ligninolysis, we conducted comparative genome analysis of C. subvermispora and P. chrysosporium. Genes encoding manganese peroxidase numbered 13 and five in C. subvermispora and P. chrysosporium, respectively. In addition, the C. subvermispora genome contains at least seven genes predicted to encode laccases, whereas the P. chrysosporium genome contains none. We also observed expansion of the number of C. subvermispora desaturase-encoding genes putatively involved in lipid metabolism. Microarray-based transcriptome analysis showed substantial up-regulation of several desaturase and MnP genes in wood-containing medium. MS identified MnP proteins in C. subvermispora culture filtrates, but none in P. chrysosporium cultures. These results support the importance of MnP and a lignin degradation mechanism whereby cleavage of the dominant nonphenolic structures is mediated by lipid peroxidation products. Two C. subvermispora genes were predicted to encode peroxidases structurally similar to P. chrysosporium lignin peroxidase and, following heterologous expression in Escherichia coli, the enzymes were shown to oxidize high redox potential substrates, but not Mn2+. Apart from oxidative lignin degradation, we also examined cellulolytic and hemicellulolytic systems in both fungi. In summary, the C. subvermispora genetic inventory and expression patterns exhibit increased oxidoreductase potential and diminished cellulolytic capability relative to P. chrysosporium.

Published
2012

5. Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015 versus enzyme-producing CBS 513.88

Author

Andersen, M.R., Salazar, Margarita P., Schaap, Peter J., van de Vondervoort, Peter J. I., Culley, D., Thykaer, Jette, Frisvad, J.C., Nielsen, K.F., Albang, R., Albermann, Kaj, Berka, R.M., Braus, G.H., Braus-Stromeyer, S.A., Corrochano, L.M., Dai, Z., van Dijck, P.W.M., Hofmann, G., Lasure, Linda L., Magnuson, J.K., Menke, H., Meijer, M., Meijer, Susan L., Nielsen, J.T., Samson, R.A., Stam, H., Tsang, Adrian, van den Brink, J., Atkins, A., Aerts, A., Shapiro, Harris, Pangilinan, Jasmyn, Salamov, A., Lou, Yigong, Lindquist, E., Lucas, S., Grimwood, J., Grigoriev, I.V., Kubicek, Christian P., Martinez, Diego, van Peij, Noel N. M. E., Roubos, Johannes A., Nielsen, Jens, Baker, S.E., Andersen, M.R., Salazar, Margarita P., Schaap, Peter J., van de Vondervoort, Peter J. I., Culley, D., Thykaer, Jette, Frisvad, J.C., Nielsen, K.F., Albang, R., Albermann, Kaj, Berka, R.M., Braus, G.H., Braus-Stromeyer, S.A., Corrochano, L.M., Dai, Z., van Dijck, P.W.M., Hofmann, G., Lasure, Linda L., Magnuson, J.K., Menke, H., Meijer, M., Meijer, Susan L., Nielsen, J.T., Samson, R.A., Stam, H., Tsang, Adrian, van den Brink, J., Atkins, A., Aerts, A., Shapiro, Harris, Pangilinan, Jasmyn, Salamov, A., Lou, Yigong, Lindquist, E., Lucas, S., Grimwood, J., Grigoriev, I.V., Kubicek, Christian P., Martinez, Diego, van Peij, Noel N. M. E., Roubos, Johannes A., Nielsen, Jens, and Baker, S.E.

Published
2011

7. Comparative genomic analysis of the thermophilic biomass-degrading fungi Myceliophthora thermophila and Thielavia terrestris

Author

Berka, R.M., Grigoriev, I.V., Otillar, Robert, Salamov, A., Grimwood, J., Reid, Ian, Ishmael, N., John, T., Darmond, C., Moisan, Marie-Claude, Henrissat, B., Coutinho, P.M., Lombard, Vincent, Natvig, Donald O., Lindquist, E., Schmutz, Jeremy, Lucas, S., Harris, P.C., Powlowski, Justin, Bellemare, A., Taylor, David, Butler, G., de Vries, R.P., Allijn, I.E., van den Brink, J., Ushinsky, Sophia, Storms, Reginald, Powell, Amy J., Paulsen, Ian T., Elbourne, L.D.H., Baker, S.E., Magnuson, J.K., LaBoissiere, Sylvie, Clutterbuck, A.J., Martinez, Diego, Wogulis, Mark, de Leon, Alfredo Lopez, Rey, Michael W., Tsang, Adrian, Berka, R.M., Grigoriev, I.V., Otillar, Robert, Salamov, A., Grimwood, J., Reid, Ian, Ishmael, N., John, T., Darmond, C., Moisan, Marie-Claude, Henrissat, B., Coutinho, P.M., Lombard, Vincent, Natvig, Donald O., Lindquist, E., Schmutz, Jeremy, Lucas, S., Harris, P.C., Powlowski, Justin, Bellemare, A., Taylor, David, Butler, G., de Vries, R.P., Allijn, I.E., van den Brink, J., Ushinsky, Sophia, Storms, Reginald, Powell, Amy J., Paulsen, Ian T., Elbourne, L.D.H., Baker, S.E., Magnuson, J.K., LaBoissiere, Sylvie, Clutterbuck, A.J., Martinez, Diego, Wogulis, Mark, de Leon, Alfredo Lopez, Rey, Michael W., and Tsang, Adrian

Published
2011

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