24 results on '"Magnusdottir, Droplaug N."'
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2. Histopathology and levels of proteins in plasma associate with survival after colorectal cancer diagnosis
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Magnusson, Magnus I., Agnarsson, Bjarni A., Jonasson, Jon G., Tryggvason, Thordur, Aeffner, Famke, le Roux, Louise, Magnusdottir, Droplaug N., Gunnarsdottir, Helga S., Alexíusdóttir, Kristín K., Gunnarsdottir, Kristbjorg, Söebech, Emilia, Runarsdottir, Hjaltey, Jonsdottir, Erna M., Kristinsdottir, Bjarney S., Olafsson, Sigurgeir, Knutsdottir, Hildur, Thorsteinsdottir, Unnur, Ulfarsson, Magnus O., Gudbjartsson, Daniel F., Saemundsdottir, Jona, Magnusson, Olafur T., Norddahl, Gudmundur L., Watson, J. E. Vivienne, Rafnar, Thorunn, Lund, Sigrun H., and Stefansson, Kari
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- 2023
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3. The sequences of 150,119 genomes in the UK Biobank
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Halldorsson, Bjarni V., Eggertsson, Hannes P., Moore, Kristjan H. S., Hauswedell, Hannes, Eiriksson, Ogmundur, Ulfarsson, Magnus O., Palsson, Gunnar, Hardarson, Marteinn T., Oddsson, Asmundur, Jensson, Brynjar O., Kristmundsdottir, Snaedis, Sigurpalsdottir, Brynja D., Stefansson, Olafur A., Beyter, Doruk, Holley, Guillaume, Tragante, Vinicius, Gylfason, Arnaldur, Olason, Pall I., Zink, Florian, Asgeirsdottir, Margret, Sverrisson, Sverrir T., Sigurdsson, Brynjar, Gudjonsson, Sigurjon A., Sigurdsson, Gunnar T., Halldorsson, Gisli H., Sveinbjornsson, Gardar, Norland, Kristjan, Styrkarsdottir, Unnur, Magnusdottir, Droplaug N., Snorradottir, Steinunn, Kristinsson, Kari, Sobech, Emilia, Jonsson, Helgi, Geirsson, Arni J., Olafsson, Isleifur, Jonsson, Palmi, Pedersen, Ole Birger, Erikstrup, Christian, Brunak, Søren, Ostrowski, Sisse Rye, Thorleifsson, Gudmar, Jonsson, Frosti, Melsted, Pall, Jonsdottir, Ingileif, Rafnar, Thorunn, Holm, Hilma, Stefansson, Hreinn, Saemundsdottir, Jona, Gudbjartsson, Daniel F., Magnusson, Olafur T., Masson, Gisli, Thorsteinsdottir, Unnur, Helgason, Agnar, Jonsson, Hakon, Sulem, Patrick, and Stefansson, Kari
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- 2022
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4. Reconstruction of a large-scale outbreak of SARS-CoV-2 infection in Iceland informs vaccination strategies
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Hjorleifsson, Kristjan E., Rognvaldsson, Solvi, Jonsson, Hakon, Agustsdottir, Arna B., Andresdottir, Margret, Birgisdottir, Kolbrun, Eiriksson, Ogmundur, Eythorsson, Elias S., Fridriksdottir, Run, Georgsson, Gudmundur, Gudmundsson, Kjartan R., Gylfason, Arnaldur, Haraldsdottir, Gudbjorg, Jensson, Brynjar O., Jonasdotti, Adalbjorg, Jonasdottir, Aslaug, Josefsdottir, Kamilla S., Kristinsdottir, Nina, Kristjansdottir, Borghildur, Kristjansson, Thordur, Magnusdottir, Droplaug N., Palsson, Runolfur, le Roux, Louise, Sigurbergsdottir, Gudrun M., Sigurdsson, Asgeir, Sigurdsson, Martin I., Sveinbjornsson, Gardar, Thorarensen, Emil Aron, Thorbjornsson, Bjarni, Thordardottir, Marianna, Helgason, Agnar, Holm, Hilma, Jonsdottir, Ingileif, Jonsson, Frosti, Magnusson, Olafur T., Masson, Gisli, Norddahl, Gudmundur L., Saemundsdottir, Jona, Sulem, Patrick, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Melsted, Pall, and Stefansson, Kari
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- 2022
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5. Long-read sequencing of 3,622 Icelanders provides insight into the role of structural variants in human diseases and other traits
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Beyter, Doruk, Ingimundardottir, Helga, Oddsson, Asmundur, Eggertsson, Hannes P., Bjornsson, Eythor, Jonsson, Hakon, Atlason, Bjarni A., Kristmundsdottir, Snaedis, Mehringer, Svenja, Hardarson, Marteinn T., Gudjonsson, Sigurjon A., Magnusdottir, Droplaug N., Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Kristjansson, Ragnar P., Sverrisson, Sverrir T., Holley, Guillaume, Palsson, Gunnar, Stefansson, Olafur A., Eyjolfsson, Gudmundur, Olafsson, Isleifur, Sigurdardottir, Olof, Torfason, Bjarni, Masson, Gisli, Helgason, Agnar, Thorsteinsdottir, Unnur, Holm, Hilma, Gudbjartsson, Daniel F., Sulem, Patrick, Magnusson, Olafur T., Halldorsson, Bjarni V., and Stefansson, Kari
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- 2021
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6. Molecular benchmarks of a SARS-CoV-2 epidemic
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Jonsson, Hakon, Magnusson, Olafur T., Melsted, Pall, Berglund, Jonas, Agustsdottir, Arna B., Eiríksdottir, Berglind, Fridriksdottir, Run, Garðarsdottir, Elisabet Eir, Georgsson, Gudmundur, Gretarsdottir, Olafia S., Guðmundsson, Kjartan R., Gunnarsdottir, Thora Rosa, Eggertsson, Hannes, Gylfason, Arnaldur, Holm, Hilma, Jensson, Brynjar O., Jonasdottir, Aslaug, Jonsson, Frosti, Josefsdottir, Kamilla S., Thordardottir, Marianna, Kristinsson, Karl G., Kristjánsson, Þórður, Magnusdottir, Droplaug N., Roux, Louise le, Saemundsdottir, Jona, Sigurdsson, Asgeir, Sigmundsdottir, Gudrun, Sveinbjornsson, Gardar, Rognvaldsson, Solvi, Eiriksson, Ogmundur, Magnusson, Magnus Karl, Sveinsdottir, Kristin Eva, Sveinsdottir, Maney, Thorarensen, Emil Aron, Thorbjornsson, Bjarni, Löve, Arthur, Norddahl, Gudmundur L., Jonsdottir, Ingileif, Sulem, Patrick, Masson, Gisli, Moller, Alma, Gudnason, Thorolfur, Kristjansson, Mar, Helgason, Agnar, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, and Stefansson, Kari
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- 2021
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7. Ancient genomes from Iceland reveal the making of a human population
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Ebenesersdóttir, S. Sunna, Sandoval-Velasco, Marcela, Gunnarsdóttir, Ellen D., Jagadeesan, Anuradha, Guðmundsdóttir, Valdís B., Thordardóttir, Elísabet L., Einarsdóttir, Margrét S., Moore, Kristjan H. S., Sigurðsson, Ásgeir, Magnúsdóttir, Droplaug N., Jónsson, Hákon, Snorradóttir, Steinunn, Hovig, Eivind, Møller, Pål, Kockum, Ingrid, Olsson, Tomas, Alfredsson, Lars, Hansen, Thomas F., Werge, Thomas, Cavalleri, Gianpiero L., Gilbert, Edmund, Lalueza-Fox, Carles, W.Walser, Joe, Kristjánsdóttir, Steinunn, Gopalakrishnan, Shyam, Árnadóttir, Lilja, Magnússon, Ólafur Þ., Gilbert, M. Thomas P., Stefánsson, Kári, and Helgason, Agnar
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- 2018
8. Insights into imprinting from parent-of-origin phased methylomes and transcriptomes
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Zink, Florian, Magnusdottir, Droplaug N., Magnusson, Olafur T., Walker, Nicolas J., Morris, Tiffany J., Sigurdsson, Asgeir, Halldorsson, Gisli H., Gudjonsson, Sigurjon A., Melsted, Pall, Ingimundardottir, Helga, Kristmundsdottir, Snædis, Alexandersson, Kristjan F., Helgadottir, Anna, Gudmundsson, Julius, Rafnar, Thorunn, Jonsdottir, Ingileif, Holm, Hilma, Eyjolfsson, Gudmundur Ingi, Sigurdardottir, Olof, Olafsson, Isleifur, Masson, Gisli, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Halldorsson, Bjarni V., Stacey, Simon N., and Stefansson, Kari
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- 2018
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9. The population genomic legacy of the second plague pandemic
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Gopalakrishnan, Shyam, Ebenesersdottir, S. Sunna, Lundström, Inge K. C., Turner-Walker, Gordon, Moore, Kristjan H. S., Luisi, Pierre, Margaryan, Ashot, Martin, Michael D., Ellegaard, Martin Rene, Magnusson, Olafur P., Sigurosson, Asgeir, Snorradottir, Steinunn, Magnusdottir, Droplaug N., Laffoon, Jason E., van Dorp, Lucy, Liu, Xiaodong, Moltke, Ida, Avila-Arcos, Maria C., Schraiber, Joshua G., Rasmussen, Simon, Juan, David, Gelabert, Pere, de-Dios, Toni, Fotakis, Anna K., Iraeta-Orbegozo, Miren, Vågene, Åshild J., Denham, Sean Dexter, Christophersen, Axel, Stenøien, Hans K., Vieira, Filipe G., Liu, Shanlin, Günther, Torsten, Kivisild, Toomas, Moseng, Ole Georg, Skar, Birgitte, Cheung, Christina, Sandoval-Velasco, Marcela, Wales, Nathan, Schroeder, Hannes, Campos, Paula F., Guomundsdottir, Valdis B., Sicheritz-Ponten, Thomas, Peterson, Bent, Halgunset, Jostein, Gilbert, Edmund, Cavalleri, Gianpiero L., Hovig, Eivind, Kockum, Ingrid, Olsson, Tomas, Alfredsson, Lars, Hansen, Thomas F., Werge, Thomas, Willerslev, Eske, Balloux, Francois, Marques-Bonet, Tomas, Lalueza-Fox, Carles, Nielsen, Rasmus, Stefansson, Kari, Holgason, Agnar, Gilbert, M. Thomas P., Gopalakrishnan, Shyam, Ebenesersdottir, S. Sunna, Lundström, Inge K. C., Turner-Walker, Gordon, Moore, Kristjan H. S., Luisi, Pierre, Margaryan, Ashot, Martin, Michael D., Ellegaard, Martin Rene, Magnusson, Olafur P., Sigurosson, Asgeir, Snorradottir, Steinunn, Magnusdottir, Droplaug N., Laffoon, Jason E., van Dorp, Lucy, Liu, Xiaodong, Moltke, Ida, Avila-Arcos, Maria C., Schraiber, Joshua G., Rasmussen, Simon, Juan, David, Gelabert, Pere, de-Dios, Toni, Fotakis, Anna K., Iraeta-Orbegozo, Miren, Vågene, Åshild J., Denham, Sean Dexter, Christophersen, Axel, Stenøien, Hans K., Vieira, Filipe G., Liu, Shanlin, Günther, Torsten, Kivisild, Toomas, Moseng, Ole Georg, Skar, Birgitte, Cheung, Christina, Sandoval-Velasco, Marcela, Wales, Nathan, Schroeder, Hannes, Campos, Paula F., Guomundsdottir, Valdis B., Sicheritz-Ponten, Thomas, Peterson, Bent, Halgunset, Jostein, Gilbert, Edmund, Cavalleri, Gianpiero L., Hovig, Eivind, Kockum, Ingrid, Olsson, Tomas, Alfredsson, Lars, Hansen, Thomas F., Werge, Thomas, Willerslev, Eske, Balloux, Francois, Marques-Bonet, Tomas, Lalueza-Fox, Carles, Nielsen, Rasmus, Stefansson, Kari, Holgason, Agnar, and Gilbert, M. Thomas P.
- Abstract
Human populations have been shaped by catastrophes that may have left long-lasting signatures in their genomes. One notable example is the second plague pandemic that entered Europe in ca. 1,347 CE and repeatedly returned for over 300 years, with typical village and town mortality estimated at 10%–40%.1 It is assumed that this high mortality affected the gene pools of these populations. First, local population crashes reduced genetic diversity. Second, a change in frequency is expected for sequence variants that may have affected survival or susceptibility to the etiologic agent (Yersinia pestis).2 Third, mass mortality might alter the local gene pools through its impact on subsequent migration patterns. We explored these factors using the Norwegian city of Trondheim as a model, by sequencing 54 genomes spanning three time periods: (1) prior to the plague striking Trondheim in 1,349 CE, (2) the 17th–19th century, and (3) the present. We find that the pandemic period shaped the gene pool by reducing long distance immigration, in particular from the British Isles, and inducing a bottleneck that reduced genetic diversity. Although we also observe an excess of large FST values at multiple loci in the genome, these are shaped by reference biases introduced by mapping our relatively low genome coverage degraded DNA to the reference genome. This implies that attempts to detect selection using ancient DNA (aDNA) datasets that vary by read length and depth of sequencing coverage may be particularly challenging until methods have been developed to account for the impact of differential reference bias on test statistics.
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- 2022
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10. Reconstruction of a large-scale outbreak of SARS-CoV-2 infection in Iceland informs vaccination strategies
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Hjorleifsson, Kristjan E, primary, Rognvaldsson, Solvi, additional, Jonsson, Hakon, additional, Agustsdottir, Arna B, additional, Andresdottir, Margret, additional, Birgisdottir, Kolbrun, additional, Eiriksson, Ogmundur, additional, Eythorsson, Elias S, additional, Fridriksdottir, Run, additional, Georgsson, Gudmundur, additional, Gudmundsson, Kjartan R, additional, Gylfason, Arnaldur, additional, Haraldsdottir, Gudbjorg, additional, Jensson, Brynjar O, additional, Jonasdottir, Adalbjorg, additional, Jonasdottir, Aslaug, additional, Josefsdottir, Kamilla S, additional, Kristinsdottir, Nina, additional, Kristjansdottir, Borghildur, additional, Kristjansson, Thordur, additional, Magnusdottir, Droplaug N, additional, Palsson, Runolfur, additional, Roux, Louise le, additional, Sigurbergsdottir, Gudrun M, additional, Sigurdsson, Asgeir, additional, Sigurdsson, Martin I, additional, Sveinbjornsson, Gardar, additional, Thorarensen, Emil Aron, additional, Thorbjornsson, Bjarni, additional, Thordardottir, Marianna, additional, Helgason, Agnar, additional, Holm, Hilma, additional, Jonsdottir, Ingileif, additional, Jonsson, Frosti, additional, Magnusson, Olafur T, additional, Masson, Gisli, additional, Norddahl, Gudmundur L, additional, Saemundsdottir, Jona, additional, Sulem, Patrick, additional, Thorsteinsdottir, Unnur, additional, Gudbjartsson, Daniel F., additional, Melsted, Pall, additional, and Stefansson, Kari, additional
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- 2021
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11. Long read sequencing of 1,817 Icelanders provides insight into the role of structural variants in human disease
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Beyter, Doruk, Ingimundardottir, Helga, Eggertsson, Hannes P., Bjornsson, Eythor, Kristmundsdottir, Snaedis, Mehringer, Svenja, Jonsson, Hakon, Hardarson, Marteinn T., Magnusdottir, Droplaug N., Kristjansson, Ragnar P., Gudjonsson, Sigurjon A., Sverrisson, Sverrir T., Holley, Guillaume, Eyjolfsson, Gudmundur, Olafsson, Isleifur, Sigurdardottir, Olof, Masson, Gisli, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Sulem, Patrick, Magnusson, Olafur T., Halldorsson, Bjarni V., and Stefansson, Kari
- Abstract
Long-read sequencing (LRS) promises to improve characterization of structural variants (SVs), a major source of genetic diversity. We generated LRS data on 1,817 Icelanders using Oxford Nanopore Technologies, and identified a median of 23,111 autosomal structural variants per individual (a median of 11,506 insertions and 11,576 deletions), spanning cumulatively a median of 9.9 Mb. We found that rare SVs are larger in size than common ones and are more likely to impact protein function. We discovered an association with a rare deletion of the first exon of PCSK9 . Carriers of this deletion have 0.93 mmol/L (1.36 sd) lower LDL cholesterol levels than the population average (p-value = 2.4·10 −22 ). We show that SVs can be accurately characterized at population scale using long read sequence data in a genomewide non-targeted fashion and how these variants impact disease.
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- 2019
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12. Humoral Immune Response to SARS-CoV-2 in Iceland
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Gudbjartsson, Daniel F., primary, Norddahl, Gudmundur L., additional, Melsted, Pall, additional, Gunnarsdottir, Kristbjorg, additional, Holm, Hilma, additional, Eythorsson, Elias, additional, Arnthorsson, Asgeir O., additional, Helgason, Dadi, additional, Bjarnadottir, Kristbjorg, additional, Ingvarsson, Ragnar F., additional, Thorsteinsdottir, Brynja, additional, Kristjansdottir, Steinunn, additional, Birgisdottir, Kolbrun, additional, Kristinsdottir, Anna M., additional, Sigurdsson, Martin I., additional, Arnadottir, Gudny A., additional, Ivarsdottir, Erna V., additional, Andresdottir, Margret, additional, Jonsson, Frosti, additional, Agustsdottir, Arna B., additional, Berglund, Jonas, additional, Eiriksdottir, Berglind, additional, Fridriksdottir, Run, additional, Gardarsdottir, Elisabet E., additional, Gottfredsson, Magnus, additional, Gretarsdottir, Olafia S., additional, Gudmundsdottir, Steinunn, additional, Gudmundsson, Kjartan R., additional, Gunnarsdottir, Thora R., additional, Gylfason, Arnaldur, additional, Helgason, Agnar, additional, Jensson, Brynjar O., additional, Jonasdottir, Aslaug, additional, Jonsson, Hakon, additional, Kristjansson, Thordur, additional, Kristinsson, Karl G., additional, Magnusdottir, Droplaug N., additional, Magnusson, Olafur T., additional, Olafsdottir, Lovisa B., additional, Rognvaldsson, Solvi, additional, le Roux, Louise, additional, Sigmundsdottir, Gudrun, additional, Sigurdsson, Asgeir, additional, Sveinbjornsson, Gardar, additional, Sveinsdottir, Kristin E., additional, Sveinsdottir, Maney, additional, Thorarensen, Emil A., additional, Thorbjornsson, Bjarni, additional, Thordardottir, Marianna, additional, Saemundsdottir, Jona, additional, Kristjansson, S. Hjortur, additional, Josefsdottir, Kamilla S., additional, Masson, Gisli, additional, Georgsson, Gudmundur, additional, Kristjansson, Mar, additional, Moller, Alma, additional, Palsson, Runolfur, additional, Gudnason, Thorolfur, additional, Thorsteinsdottir, Unnur, additional, Jonsdottir, Ingileif, additional, Sulem, Patrick, additional, and Stefansson, Kari, additional
- Published
- 2020
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13. Spread of SARS-CoV-2 in the Icelandic Population
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Gudbjartsson, Daniel F., primary, Helgason, Agnar, additional, Jonsson, Hakon, additional, Magnusson, Olafur T., additional, Melsted, Pall, additional, Norddahl, Gudmundur L., additional, Saemundsdottir, Jona, additional, Sigurdsson, Asgeir, additional, Sulem, Patrick, additional, Agustsdottir, Arna B., additional, Eiriksdottir, Berglind, additional, Fridriksdottir, Run, additional, Gardarsdottir, Elisabet E., additional, Georgsson, Gudmundur, additional, Gretarsdottir, Olafia S., additional, Gudmundsson, Kjartan R., additional, Gunnarsdottir, Thora R., additional, Gylfason, Arnaldur, additional, Holm, Hilma, additional, Jensson, Brynjar O., additional, Jonasdottir, Aslaug, additional, Jonsson, Frosti, additional, Josefsdottir, Kamilla S., additional, Kristjansson, Thordur, additional, Magnusdottir, Droplaug N., additional, le Roux, Louise, additional, Sigmundsdottir, Gudrun, additional, Sveinbjornsson, Gardar, additional, Sveinsdottir, Kristin E., additional, Sveinsdottir, Maney, additional, Thorarensen, Emil A., additional, Thorbjornsson, Bjarni, additional, Löve, Arthur, additional, Masson, Gisli, additional, Jonsdottir, Ingileif, additional, Möller, Alma D., additional, Gudnason, Thorolfur, additional, Kristinsson, Karl G., additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional
- Published
- 2020
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14. Early Spread of SARS-Cov-2 in the Icelandic Population
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Gudbjartsson, Daniel F, primary, Helgason, Agnar, additional, Jonsson, Hakon, additional, Magnusson, Olafur T, additional, Melsted, Pall, additional, Norddahl, Gudmundur L, additional, Saemundsdottir, Jona, additional, Sigurdsson, Asgeir, additional, Sulem, Patrick, additional, Agustsdottir, Arna B, additional, Eiriksdottir, Berglind, additional, Fridriksdottir, Run, additional, Gardarsdottir, Elisabet E, additional, Georgsson, Gudmundur, additional, Gretarsdottir, Olafia S, additional, Gudmundsson, Kjartan R, additional, Gunnarsdottir, Thora R, additional, Gylfason, Arnaldur, additional, Holm, Hilma, additional, Jensson, Brynjar O, additional, Jonasdottir, Aslaug, additional, Jonsson, Frosti, additional, Josefsdottir, Kamilla S, additional, Kristjansson, Thordur, additional, Magnusdottir, Droplaug N, additional, Roux, Louise le, additional, Sigmundsdottir, Gudrun, additional, Sveinbjornsson, Gardar, additional, Sveinsdottir, Kristin E, additional, Sveinsdottir, Maney, additional, Thorarensen, Emil A, additional, Thorbjornsson, Bjarni, additional, Löve, Arthur, additional, Masson, Gisli, additional, Jonsdottir, Ingileif, additional, Moller, Alma, additional, Gudnason, Thorolfur, additional, Kristinsson, Karl G, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional
- Published
- 2020
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15. Long read sequencing of 3,622 Icelanders provides insight into the role of structural variants in human diseases and other traits
- Author
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Beyter, Doruk, primary, Ingimundardottir, Helga, additional, Oddsson, Asmundur, additional, Eggertsson, Hannes P., additional, Bjornsson, Eythor, additional, Jonsson, Hakon, additional, Atlason, Bjarni A., additional, Kristmundsdottir, Snaedis, additional, Mehringer, Svenja, additional, Hardarson, Marteinn T., additional, Gudjonsson, Sigurjon A., additional, Magnusdottir, Droplaug N., additional, Jonasdottir, Aslaug, additional, Jonasdottir, Adalbjorg, additional, Kristjansson, Ragnar P., additional, Sverrisson, Sverrir T., additional, Holley, Guillaume, additional, Palsson, Gunnar, additional, Stefansson, Olafur A., additional, Eyjolfsson, Gudmundur, additional, Olafsson, Isleifur, additional, Sigurdardottir, Olof, additional, Torfason, Bjarni, additional, Masson, Gisli, additional, Helgason, Agnar, additional, Thorsteinsdottir, Unnur, additional, Holm, Hilma, additional, Gudbjartsson, Daniel F., additional, Sulem, Patrick, additional, Magnusson, Olafur T., additional, Halldorsson, Bjarni V., additional, and Stefansson, Kari, additional
- Published
- 2019
- Full Text
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16. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
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Gudmundsson, Julius, Sulem, Patrick, Rafnar, Thorunn, Bergthorsson, Jon T, Manolescu, Andrei, Gudbjartsson, Daniel, Agnarsson, Bjarni A, Sigurdsson, Asgeir, Benediktsdottir, Kristrun R, Blondal, Thorarinn, Jakobsdottir, Margret, Stacey, Simon N, Kostic, Jelena, Kristinsson, Kari T, Birgisdottir, Birgitta, Ghosh, Shyamali, Magnusdottir, Droplaug N, Thorlacius, Steinunn, Thorleifsson, Gudmar, Zheng, S Lilly, Sun, Jielin, Chang, Bao-Li, Elmore, J Bradford, Breyer, Joan P, McReynolds, Kate M, Bradley, Kevin M, Yaspan, Brian L, Wiklund, Fredrik, Stattin, Pär, Lindström, Sara, Adami, Hans-Olov, McDonnell, Shannon K, Schaid, Daniel J, Cunningham, Julie M, Wang, Liang, Cerhan, James R, St Sauver, Jennifer L, Isaacs, Sara D, Wiley, Kathleen E, Partin, Alan W, Walsh, Patrick C, Polo, Sonia, Ruiz-Echarri, Manuel, Navarrete, Sebastian, Fuertes, Fernando, Saez, Berta, Godino, Javier, Weijerman, Philip C, Swinkels, Dorine W, Aben, Katja K, Witjes, J Alfred, Suarez, Brian K, Helfand, Brian T, Frigge, Michael L, Kristjansson, Kristleifur, Ober, Carole, Jonsson, Eirikur, Einarsson, Gudmundur V, Xu, Jianfeng, Gronberg, Henrik, Smith, Jeffrey R, Thibodeau, Stephen N, Isaacs, William B, Catalona, William J, Mayordomo, Jose I, Kiemeney, Lambertus A, Barkardottir, Rosa B, Gulcher, Jeffrey R, Thorsteinsdottir, Unnur, Kong, Augustine, Stefansson, Kari, Gudmundsson, Julius, Sulem, Patrick, Rafnar, Thorunn, Bergthorsson, Jon T, Manolescu, Andrei, Gudbjartsson, Daniel, Agnarsson, Bjarni A, Sigurdsson, Asgeir, Benediktsdottir, Kristrun R, Blondal, Thorarinn, Jakobsdottir, Margret, Stacey, Simon N, Kostic, Jelena, Kristinsson, Kari T, Birgisdottir, Birgitta, Ghosh, Shyamali, Magnusdottir, Droplaug N, Thorlacius, Steinunn, Thorleifsson, Gudmar, Zheng, S Lilly, Sun, Jielin, Chang, Bao-Li, Elmore, J Bradford, Breyer, Joan P, McReynolds, Kate M, Bradley, Kevin M, Yaspan, Brian L, Wiklund, Fredrik, Stattin, Pär, Lindström, Sara, Adami, Hans-Olov, McDonnell, Shannon K, Schaid, Daniel J, Cunningham, Julie M, Wang, Liang, Cerhan, James R, St Sauver, Jennifer L, Isaacs, Sara D, Wiley, Kathleen E, Partin, Alan W, Walsh, Patrick C, Polo, Sonia, Ruiz-Echarri, Manuel, Navarrete, Sebastian, Fuertes, Fernando, Saez, Berta, Godino, Javier, Weijerman, Philip C, Swinkels, Dorine W, Aben, Katja K, Witjes, J Alfred, Suarez, Brian K, Helfand, Brian T, Frigge, Michael L, Kristjansson, Kristleifur, Ober, Carole, Jonsson, Eirikur, Einarsson, Gudmundur V, Xu, Jianfeng, Gronberg, Henrik, Smith, Jeffrey R, Thibodeau, Stephen N, Isaacs, William B, Catalona, William J, Mayordomo, Jose I, Kiemeney, Lambertus A, Barkardottir, Rosa B, Gulcher, Jeffrey R, Thorsteinsdottir, Unnur, Kong, Augustine, and Stefansson, Kari
- Published
- 2008
17. A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer
- Author
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Gudmundsson, Julius, primary, Sulem, Patrick, additional, Gudbjartsson, Daniel F, additional, Masson, Gisli, additional, Agnarsson, Bjarni A, additional, Benediktsdottir, Kristrun R, additional, Sigurdsson, Asgeir, additional, Magnusson, Olafur Th, additional, Gudjonsson, Sigurjon A, additional, Magnusdottir, Droplaug N, additional, Johannsdottir, Hrefna, additional, Helgadottir, Hafdis Th, additional, Stacey, Simon N, additional, Jonasdottir, Adalbjorg, additional, Olafsdottir, Stefania B, additional, Thorleifsson, Gudmar, additional, Jonasson, Jon G, additional, Tryggvadottir, Laufey, additional, Navarrete, Sebastian, additional, Fuertes, Fernando, additional, Helfand, Brian T, additional, Hu, Qiaoyan, additional, Csiki, Irma E, additional, Mates, Ioan N, additional, Jinga, Viorel, additional, Aben, Katja K H, additional, van Oort, Inge M, additional, Vermeulen, Sita H, additional, Donovan, Jenny L, additional, Hamdy, Freddy C, additional, Ng, Chi-Fai, additional, Chiu, Peter K F, additional, Lau, Kin-Mang, additional, Ng, Maggie C Y, additional, Gulcher, Jeffrey R, additional, Kong, Augustine, additional, Catalona, William J, additional, Mayordomo, Jose I, additional, Einarsson, Gudmundur V, additional, Barkardottir, Rosa B, additional, Jonsson, Eirikur, additional, Mates, Dana, additional, Neal, David E, additional, Kiemeney, Lambertus A, additional, Thorsteinsdottir, Unnur, additional, Rafnar, Thorunn, additional, and Stefansson, Kari, additional
- Published
- 2012
- Full Text
- View/download PDF
18. A common variant associated with prostate cancer in European and African populations
- Author
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Amundadottir, Laufey T, Sulem, Patrick, Gudmundsson, Julius, Helgasson, Agnar, Baker, Adam, Agnarsson, Bjarni A, Sigurdsson, Asgeir, Benediktsdottir, Kristrun R, Cazier, Jean-Baptiste, Sainz, Jesus, Jakobsdottir, Margret, Kostic, Jelena, Magnusdottir, Droplaug N, Gosh, Shyamali, Agnarsson, Kari, Birgisdottir, Birgitta, Le Roux, Louise, Olafsdottir, Adalheidur, Blondal, Thorarinn, Andresdottir, Margret, Gretarsdottir, Olafia Svandis, Bergthorsson, Jon T, Gudbjartsson, Daniel, Gylfason, Arnaldur, Thorleifsson, Gudmar, Manolescu, Andrei, Kristjansson, Kristleifur, Geirsson, Gudmundur, Isaksson, Helgi, Douglas, Julie, Johansson, Jan-Erik, Bälter, Katarina, Wiklund, Fredrik, Montie, James E, Yu, Xiaoying, Suarez, Brian K, Ober, Carole, Cooney, Kathleen A, Grönberg, Henrik, Catalona, William J, Einarsson, Gudmundur V, Barkardottir, Rosa B, Gulcher, Jeffrey R, Kong, Augustine, Thorsteinsdottir, Unnur, Stefansson, Kari, Amundadottir, Laufey T, Sulem, Patrick, Gudmundsson, Julius, Helgasson, Agnar, Baker, Adam, Agnarsson, Bjarni A, Sigurdsson, Asgeir, Benediktsdottir, Kristrun R, Cazier, Jean-Baptiste, Sainz, Jesus, Jakobsdottir, Margret, Kostic, Jelena, Magnusdottir, Droplaug N, Gosh, Shyamali, Agnarsson, Kari, Birgisdottir, Birgitta, Le Roux, Louise, Olafsdottir, Adalheidur, Blondal, Thorarinn, Andresdottir, Margret, Gretarsdottir, Olafia Svandis, Bergthorsson, Jon T, Gudbjartsson, Daniel, Gylfason, Arnaldur, Thorleifsson, Gudmar, Manolescu, Andrei, Kristjansson, Kristleifur, Geirsson, Gudmundur, Isaksson, Helgi, Douglas, Julie, Johansson, Jan-Erik, Bälter, Katarina, Wiklund, Fredrik, Montie, James E, Yu, Xiaoying, Suarez, Brian K, Ober, Carole, Cooney, Kathleen A, Grönberg, Henrik, Catalona, William J, Einarsson, Gudmundur V, Barkardottir, Rosa B, Gulcher, Jeffrey R, Kong, Augustine, Thorsteinsdottir, Unnur, and Stefansson, Kari
- Published
- 2006
- Full Text
- View/download PDF
19. A common variant associated with prostate cancer in European and African populations
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Amundadottir, Laufey T., Sulem, Patrick, Gudmundsson, Julius, Helgason, Agnar, Baker, Adam, Agnarsson, Bjarni A., Sigurdsson, Asgeir, Benediktsdottir, Kristrun R., Cazier, Jean-Baptiste, Sainz, Jesus, Jakobsdottir, Margret, Kostic, Jelena, Magnusdottir, Droplaug N., Ghosh, Shyamali, Agnarsson, Kari, Birgisdottir, Birgitta, Le Roux, Louise, Olafsdottir, Adalheidur, Blondal, Thorarinn, Andresdottir, Margret, Gretarsdottir, Olafia Svandis, Bergthorsson, Jon T., Gudbjartsson, Daniel, Gylfason, Arnaldur, Thorleifsson, Gudmar, Manolescu, Andrei, Kristjansson, Kristleifur, Geirsson, Gudmundur, Isaksson, Helgi, Douglas, Julie, Johansson, Jan-Erik, Bälter, Katarina, Wiklund, Fredrik, Montie, James E., Yu, Xiaoying, Suarez, Brian K., Ober, Carole, Cooney, Kathleen A., Gronberg, Henrik, Catalona, William J., Einarsson, Gudmundur V., Barkardottir, Rosa B., Gulcher, Jeffrey R., Kong, Augustine, Thorsteinsdottir, Unnur, Stefansson, Kari, Amundadottir, Laufey T., Sulem, Patrick, Gudmundsson, Julius, Helgason, Agnar, Baker, Adam, Agnarsson, Bjarni A., Sigurdsson, Asgeir, Benediktsdottir, Kristrun R., Cazier, Jean-Baptiste, Sainz, Jesus, Jakobsdottir, Margret, Kostic, Jelena, Magnusdottir, Droplaug N., Ghosh, Shyamali, Agnarsson, Kari, Birgisdottir, Birgitta, Le Roux, Louise, Olafsdottir, Adalheidur, Blondal, Thorarinn, Andresdottir, Margret, Gretarsdottir, Olafia Svandis, Bergthorsson, Jon T., Gudbjartsson, Daniel, Gylfason, Arnaldur, Thorleifsson, Gudmar, Manolescu, Andrei, Kristjansson, Kristleifur, Geirsson, Gudmundur, Isaksson, Helgi, Douglas, Julie, Johansson, Jan-Erik, Bälter, Katarina, Wiklund, Fredrik, Montie, James E., Yu, Xiaoying, Suarez, Brian K., Ober, Carole, Cooney, Kathleen A., Gronberg, Henrik, Catalona, William J., Einarsson, Gudmundur V., Barkardottir, Rosa B., Gulcher, Jeffrey R., Kong, Augustine, Thorsteinsdottir, Unnur, and Stefansson, Kari
- Abstract
With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.
- Published
- 2006
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20. Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility
- Author
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Gudmundsson, Julius, primary, Sulem, Patrick, additional, Gudbjartsson, Daniel F, additional, Blondal, Thorarinn, additional, Gylfason, Arnaldur, additional, Agnarsson, Bjarni A, additional, Benediktsdottir, Kristrun R, additional, Magnusdottir, Droplaug N, additional, Orlygsdottir, Gudbjorg, additional, Jakobsdottir, Margret, additional, Stacey, Simon N, additional, Sigurdsson, Asgeir, additional, Wahlfors, Tiina, additional, Tammela, Teuvo, additional, Breyer, Joan P, additional, McReynolds, Kate M, additional, Bradley, Kevin M, additional, Saez, Berta, additional, Godino, Javier, additional, Navarrete, Sebastian, additional, Fuertes, Fernando, additional, Murillo, Laura, additional, Polo, Eduardo, additional, Aben, Katja K, additional, van Oort, Inge M, additional, Suarez, Brian K, additional, Helfand, Brian T, additional, Kan, Donghui, additional, Zanon, Carlo, additional, Frigge, Michael L, additional, Kristjansson, Kristleifur, additional, Gulcher, Jeffrey R, additional, Einarsson, Gudmundur V, additional, Jonsson, Eirikur, additional, Catalona, William J, additional, Mayordomo, Jose I, additional, Kiemeney, Lambertus A, additional, Smith, Jeffrey R, additional, Schleutker, Johanna, additional, Barkardottir, Rosa B, additional, Kong, Augustine, additional, Thorsteinsdottir, Unnur, additional, Rafnar, Thorunn, additional, and Stefansson, Kari, additional
- Published
- 2009
- Full Text
- View/download PDF
21. New common variants affecting susceptibility to basal cell carcinoma
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Stacey, Simon N, primary, Sulem, Patrick, additional, Masson, Gisli, additional, Gudjonsson, Sigurjon A, additional, Thorleifsson, Gudmar, additional, Jakobsdottir, Margret, additional, Sigurdsson, Asgeir, additional, Gudbjartsson, Daniel F, additional, Sigurgeirsson, Bardur, additional, Benediktsdottir, Kristrun R, additional, Thorisdottir, Kristin, additional, Ragnarsson, Rafn, additional, Scherer, Dominique, additional, Hemminki, Kari, additional, Rudnai, Peter, additional, Gurzau, Eugene, additional, Koppova, Kvetoslava, additional, Botella-Estrada, Rafael, additional, Soriano, Virtudes, additional, Juberias, Pablo, additional, Saez, Berta, additional, Gilaberte, Yolanda, additional, Fuentelsaz, Victoria, additional, Corredera, Cristina, additional, Grasa, Matilde, additional, Höiom, Veronica, additional, Lindblom, Annika, additional, Bonenkamp, Johannes J, additional, van Rossum, Michelle M, additional, Aben, Katja K H, additional, de Vries, Esther, additional, Santinami, Mario, additional, Di Mauro, Maria G, additional, Maurichi, Andrea, additional, Wendt, Judith, additional, Hochleitner, Pia, additional, Pehamberger, Hubert, additional, Gudmundsson, Julius, additional, Magnusdottir, Droplaug N, additional, Gretarsdottir, Solveig, additional, Holm, Hilma, additional, Steinthorsdottir, Valgerdur, additional, Frigge, Michael L, additional, Blondal, Thorarinn, additional, Saemundsdottir, Jona, additional, Bjarnason, Hjördis, additional, Kristjansson, Kristleifur, additional, Bjornsdottir, Gyda, additional, Okamoto, Ichiro, additional, Rivoltini, Licia, additional, Rodolfo, Monica, additional, Kiemeney, Lambertus A, additional, Hansson, Johan, additional, Nagore, Eduardo, additional, Mayordomo, José I, additional, Kumar, Rajiv, additional, Karagas, Margaret R, additional, Nelson, Heather H, additional, Gulcher, Jeffrey R, additional, Rafnar, Thorunn, additional, Thorsteinsdottir, Unnur, additional, Olafsson, Jon H, additional, Kong, Augustine, additional, and Stefansson, Kari, additional
- Published
- 2009
- Full Text
- View/download PDF
22. Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations
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Gudmundsson, Julius, primary, Sulem, Patrick, additional, Gudbjartsson, Daniel F, additional, Jonasson, Jon G, additional, Sigurdsson, Asgeir, additional, Bergthorsson, Jon T, additional, He, Huiling, additional, Blondal, Thorarinn, additional, Geller, Frank, additional, Jakobsdottir, Margret, additional, Magnusdottir, Droplaug N, additional, Matthiasdottir, Sigurborg, additional, Stacey, Simon N, additional, Skarphedinsson, Oskar B, additional, Helgadottir, Hafdis, additional, Li, Wei, additional, Nagy, Rebecca, additional, Aguillo, Esperanza, additional, Faure, Eduardo, additional, Prats, Enrique, additional, Saez, Berta, additional, Martinez, Mariano, additional, Eyjolfsson, Gudmundur I, additional, Bjornsdottir, Unnur S, additional, Holm, Hilma, additional, Kristjansson, Kristleifur, additional, Frigge, Michael L, additional, Kristvinsson, Hoskuldur, additional, Gulcher, Jeffrey R, additional, Jonsson, Thorvaldur, additional, Rafnar, Thorunn, additional, Hjartarsson, Hannes, additional, Mayordomo, Jose I, additional, de la Chapelle, Albert, additional, Hrafnkelsson, Jon, additional, Thorsteinsdottir, Unnur, additional, Kong, Augustine, additional, and Stefansson, Kari, additional
- Published
- 2009
- Full Text
- View/download PDF
23. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer
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Gudmundsson, Julius, primary, Sulem, Patrick, additional, Rafnar, Thorunn, additional, Bergthorsson, Jon T, additional, Manolescu, Andrei, additional, Gudbjartsson, Daniel, additional, Agnarsson, Bjarni A, additional, Sigurdsson, Asgeir, additional, Benediktsdottir, Kristrun R, additional, Blondal, Thorarinn, additional, Jakobsdottir, Margret, additional, Stacey, Simon N, additional, Kostic, Jelena, additional, Kristinsson, Kari T, additional, Birgisdottir, Birgitta, additional, Ghosh, Shyamali, additional, Magnusdottir, Droplaug N, additional, Thorlacius, Steinunn, additional, Thorleifsson, Gudmar, additional, Zheng, S Lilly, additional, Sun, Jielin, additional, Chang, Bao-Li, additional, Elmore, J Bradford, additional, Breyer, Joan P, additional, McReynolds, Kate M, additional, Bradley, Kevin M, additional, Yaspan, Brian L, additional, Wiklund, Fredrik, additional, Stattin, Par, additional, Lindström, Sara, additional, Adami, Hans-Olov, additional, McDonnell, Shannon K, additional, Schaid, Daniel J, additional, Cunningham, Julie M, additional, Wang, Liang, additional, Cerhan, James R, additional, St Sauver, Jennifer L, additional, Isaacs, Sara D, additional, Wiley, Kathleen E, additional, Partin, Alan W, additional, Walsh, Patrick C, additional, Polo, Sonia, additional, Ruiz-Echarri, Manuel, additional, Navarrete, Sebastian, additional, Fuertes, Fernando, additional, Saez, Berta, additional, Godino, Javier, additional, Weijerman, Philip C, additional, Swinkels, Dorine W, additional, Aben, Katja K, additional, Witjes, J Alfred, additional, Suarez, Brian K, additional, Helfand, Brian T, additional, Frigge, Michael L, additional, Kristjansson, Kristleifur, additional, Ober, Carole, additional, Jonsson, Eirikur, additional, Einarsson, Gudmundur V, additional, Xu, Jianfeng, additional, Gronberg, Henrik, additional, Smith, Jeffrey R, additional, Thibodeau, Stephen N, additional, Isaacs, William B, additional, Catalona, William J, additional, Mayordomo, Jose I, additional, Kiemeney, Lambertus A, additional, Barkardottir, Rosa B, additional, Gulcher, Jeffrey R, additional, Thorsteinsdottir, Unnur, additional, Kong, Augustine, additional, and Stefansson, Kari, additional
- Published
- 2008
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24. A common variant associated with prostate cancer in European and African populations
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Amundadottir, Laufey T, primary, Sulem, Patrick, additional, Gudmundsson, Julius, additional, Helgason, Agnar, additional, Baker, Adam, additional, Agnarsson, Bjarni A, additional, Sigurdsson, Asgeir, additional, Benediktsdottir, Kristrun R, additional, Cazier, Jean-Baptiste, additional, Sainz, Jesus, additional, Jakobsdottir, Margret, additional, Kostic, Jelena, additional, Magnusdottir, Droplaug N, additional, Ghosh, Shyamali, additional, Agnarsson, Kari, additional, Birgisdottir, Birgitta, additional, Le Roux, Louise, additional, Olafsdottir, Adalheidur, additional, Blondal, Thorarinn, additional, Andresdottir, Margret, additional, Gretarsdottir, Olafia Svandis, additional, Bergthorsson, Jon T, additional, Gudbjartsson, Daniel, additional, Gylfason, Arnaldur, additional, Thorleifsson, Gudmar, additional, Manolescu, Andrei, additional, Kristjansson, Kristleifur, additional, Geirsson, Gudmundur, additional, Isaksson, Helgi, additional, Douglas, Julie, additional, Johansson, Jan-Erik, additional, Bälter, Katarina, additional, Wiklund, Fredrik, additional, Montie, James E, additional, Yu, Xiaoying, additional, Suarez, Brian K, additional, Ober, Carole, additional, Cooney, Kathleen A, additional, Gronberg, Henrik, additional, Catalona, William J, additional, Einarsson, Gudmundur V, additional, Barkardottir, Rosa B, additional, Gulcher, Jeffrey R, additional, Kong, Augustine, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional
- Published
- 2006
- Full Text
- View/download PDF
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