26 results on '"Magnusdottir, Audur"'
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2. Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease
3. Self Association and Cyclodextrin Solubilization of NSAIDs
4. The Effects of Cyclodextrins on Hydrocortisone Permeability Through Semi-Permeable Membranes
5. The Crystal Structure of a Human PP2A Phosphatase Activator Reveals a Novel Fold and Highly Conserved Cleft Implicated in Protein-Protein Interactions
6. A rare missense mutation in MYH6 associates with non-syndromic coarctation of the aorta
7. Unmarriages: Women, Men and Sexual Unions in the Middle Ages Ruth Mazo Karras
8. A Missense Variant in PLEC Increases Risk of Atrial Fibrillation
9. A rare missense mutation inMYH6confers high risk of coarctation of the aorta
10. Erratum: Corrigendum: Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis
11. VariantASGR1Associated with a Reduced Risk of Coronary Artery Disease
12. Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease
13. A Splice Region Variant in LDLR Lowers Non-high Density Lipoprotein Cholesterol and Protects against Coronary Artery Disease
14. A Splice Region Variant in LDLR Lowers Non-high Density Lipoprotein Cholesterol and Protects against Coronary Artery Disease
15. The structure of the PP2A regulatory subunit B56gamma : The remaining piece of the PP2A jigsaw puzzle
- Abstract
The PP2A serine/threonine phosphatase regulates a plethora of cellular processes. In the cell the predominant form of the enzyme is a heterotrimer, formed by a core dimer composed of a catalytic and a scaffolding subunit, which assemble together with one of a range of different regulatory B subunits. Here, we present the first structure of a free non-complexed B subunit, B56
![]("http://onlinelibrarystatic.wiley.com/undisplayable_characters/0003b3.gif")
. Comparison with the recent structures of a heterotrimeric complex and the core dimer reveals several significant conformational changes in the interface region between the B56 and the core dimer. These allow for an assembly scheme of the PP2A holoenzyme to be put forth where B56 first complexes with the scaffolding subunit and subsequently binds to the catalytic subunit and this induces the formation of a binding site for the invariant C-terminus of the catalytic subunit that locks in the complex as a last step of assembly.
16. Colony filtration blot: a new screening method for soluble protein expression in Escherichia coli
17. Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis
18. Enabling IMAC purification of low abundance recombinant proteins from E. coli lysates
19. The structure of the PP2A regulatory subunit B56γ: The remaining piece of the PP2A jigsaw puzzle
20. An efficient and generic strategy for producing soluble human proteins and domains in E. coli by screening construct libraries
21. Colony filtration blot: a new screening method for soluble protein expression in Escherichia coli
22. IMAC purification has severe and serious limitations : Means for improvement
23. Corrigendum: Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis
24. Nordic Inheritance Law through the Ages:Spaces of Action and Legal Strategies
25. The right order of things:inheritance law in the Danish-Norwegian legal literature of the early modern period
26. The structure of the PP2A regulatory subunit B56 gamma: the remaining piece of the PP2A jigsaw puzzle.
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